DE59309388D1 - Verfahren zur Herstellung von festen Arzneiformkörpern mit protrahierter 2-Stufen-Freisetzung - Google Patents
Verfahren zur Herstellung von festen Arzneiformkörpern mit protrahierter 2-Stufen-FreisetzungInfo
- Publication number
- DE59309388D1 DE59309388D1 DE59309388T DE59309388T DE59309388D1 DE 59309388 D1 DE59309388 D1 DE 59309388D1 DE 59309388 T DE59309388 T DE 59309388T DE 59309388 T DE59309388 T DE 59309388T DE 59309388 D1 DE59309388 D1 DE 59309388D1
- Authority
- DE
- Germany
- Prior art keywords
- production
- solid pharmaceutical
- protracted
- pharmaceutical tablets
- stage release
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/2063—Proteins, e.g. gelatin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1658—Proteins, e.g. albumin, gelatin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2068—Compounds of unknown constitution, e.g. material from plants or animals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE59309388T DE59309388D1 (de) | 1992-08-04 | 1993-07-28 | Verfahren zur Herstellung von festen Arzneiformkörpern mit protrahierter 2-Stufen-Freisetzung |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE4225730A DE4225730C2 (de) | 1992-08-04 | 1992-08-04 | Verfahren zur Herstellung von festen Arzneiformkörpern mit protrahierter 2-Stufen-Freisetzung |
DE59309388T DE59309388D1 (de) | 1992-08-04 | 1993-07-28 | Verfahren zur Herstellung von festen Arzneiformkörpern mit protrahierter 2-Stufen-Freisetzung |
Publications (1)
Publication Number | Publication Date |
---|---|
DE59309388D1 true DE59309388D1 (de) | 1999-04-01 |
Family
ID=6464804
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE4225730A Expired - Lifetime DE4225730C2 (de) | 1992-08-04 | 1992-08-04 | Verfahren zur Herstellung von festen Arzneiformkörpern mit protrahierter 2-Stufen-Freisetzung |
DE59309388T Expired - Lifetime DE59309388D1 (de) | 1992-08-04 | 1993-07-28 | Verfahren zur Herstellung von festen Arzneiformkörpern mit protrahierter 2-Stufen-Freisetzung |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE4225730A Expired - Lifetime DE4225730C2 (de) | 1992-08-04 | 1992-08-04 | Verfahren zur Herstellung von festen Arzneiformkörpern mit protrahierter 2-Stufen-Freisetzung |
Country Status (17)
Country | Link |
---|---|
US (1) | US5382601A (de) |
EP (1) | EP0582186B1 (de) |
JP (1) | JP3560244B2 (de) |
CN (1) | CN1086708A (de) |
AT (1) | ATE176866T1 (de) |
AU (1) | AU669731B2 (de) |
CA (1) | CA2141691C (de) |
DE (2) | DE4225730C2 (de) |
DK (1) | DK0582186T3 (de) |
ES (1) | ES2128369T3 (de) |
GR (1) | GR3030227T3 (de) |
IL (1) | IL106580A (de) |
LT (1) | LT3201B (de) |
LV (1) | LV10182B (de) |
MX (1) | MX9304675A (de) |
WO (1) | WO1994003158A1 (de) |
ZA (1) | ZA935614B (de) |
Families Citing this family (57)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5817336A (en) * | 1993-04-02 | 1998-10-06 | Orion-Yhtyma Oy | Composition containing selegiline |
AUPN605795A0 (en) * | 1995-10-19 | 1995-11-09 | F.H. Faulding & Co. Limited | Analgesic pharmaceutical composition |
US6139872A (en) * | 1996-08-14 | 2000-10-31 | Henkel Corporation | Method of producing a vitamin product |
US5866585A (en) * | 1997-05-22 | 1999-02-02 | Synchroneuron, Llc | Methods of treating tardive dyskinesia using NMDA receptor antagonists |
US6057373A (en) * | 1997-05-22 | 2000-05-02 | Synchroneuron, Llc | Methods of treating tardive dyskinesia and other movement disorders using NMDA receptor antagonists |
AU3860797A (en) * | 1997-07-16 | 1999-02-10 | Antrin Research Limited | Pharmaceutical formulations for oral administration |
US5980941A (en) * | 1997-08-20 | 1999-11-09 | Fuisz Technologies Ltd. | Self-binding shearform compositions |
US5840334A (en) * | 1997-08-20 | 1998-11-24 | Fuisz Technologies Ltd. | Self-binding shearform compositions |
US5952389A (en) * | 1998-01-13 | 1999-09-14 | Synchroneuron | Methods of treating tardive dyskinesia and other movement disorders |
US6294583B1 (en) * | 1998-01-13 | 2001-09-25 | Synchroneuron, Llc | Methods of treating tardive dyskinesia and other movement disorders |
DE19809242A1 (de) * | 1998-03-05 | 1999-09-09 | Basf Ag | Verfahren zur Herstellung von festen, sphärischen Formkörpern, enthaltend pharmazeutische Wirkstoffe in einer Bindemittelmatrix |
DE19814257A1 (de) * | 1998-03-31 | 1999-10-07 | Asta Medica Ag | Brauseformulierungen |
US6444702B1 (en) | 2000-02-22 | 2002-09-03 | Neuromolecular, Inc. | Aminoadamantane derivatives as therapeutic agents |
US20040122090A1 (en) * | 2001-12-07 | 2004-06-24 | Lipton Stuart A. | Methods for treating neuropsychiatric disorders with nmda receptor antagonists |
EP1852113A3 (de) * | 2000-12-07 | 2008-03-12 | Neuromolecular Inc. | Verfahren zur Behandlung neuropsychiatrischer Erkrankungen mit NMDA-Rezeptorantagonisten |
EP1715843A1 (de) * | 2004-01-29 | 2006-11-02 | Neuromolecular Inc. | Kombination eines nmda-rezeptor-antagonisten und eines mao-hemmers oder eines gadph-hemmers zur behandlung von erkrankungen im zusammenhang mit dem zentralen nervensystem |
WO2005079773A2 (en) * | 2004-02-13 | 2005-09-01 | Neuromolecular, Inc. | Combination of an nmda receptor antagonist and an anti-epileptic drug for the treatment of epilepsy and other cns disorders |
JP2007522249A (ja) * | 2004-02-13 | 2007-08-09 | ニューロモレキュラー・インコーポレイテッド | 精神医学的状態の処置のための、nmdaレセプターアンタゴニストと、抗うつ薬であるmaoインヒビターまたはgadphインヒビターとの併用 |
US20060002999A1 (en) | 2004-06-17 | 2006-01-05 | Forest Laboratories, Inc. | Immediate release formulations of 1-aminocyclohexane compounds, memantine and neramexane |
KR100901927B1 (ko) * | 2004-06-17 | 2009-06-10 | 메르츠 파마 게엠베하 운트 코. 카가아 | 메만타인 또는 네라멕산의 직접 압축으로 제조된 마실수 있는 즉시 방출형 제제 |
EP1765287A2 (de) | 2004-06-17 | 2007-03-28 | Merz Pharma GmbH & Co. KGaA | Formulierungen für die sofortige freisetzung oraler memantin-darreichungsformen |
AU2005265031A1 (en) * | 2004-06-17 | 2006-01-26 | Forest Laboratories, Inc. | Modified release formulation of memantine |
EP2343057A1 (de) * | 2004-11-23 | 2011-07-13 | Neuromolecular Pharmaceuticals, Inc | Verfahren und Zusammensetzung zur Verabreichung eines NMDA-Rezeptorantagonisten an eine Person |
US7619007B2 (en) * | 2004-11-23 | 2009-11-17 | Adamas Pharmaceuticals, Inc. | Method and composition for administering an NMDA receptor antagonist to a subject |
CA2588296A1 (en) | 2004-11-24 | 2006-06-01 | Neuromolecular Pharmaceuticals, Inc. | Composition comprising an nmda receptor antagonist and levodopa and use thereof for treating neurological disease |
US20090208579A1 (en) * | 2004-12-27 | 2009-08-20 | Eisai R & D Management Co., Ltd. | Matrix Type Sustained-Release Preparation Containing Basic Drug or Salt Thereof, and Method for Manufacturing the Same |
US20070129402A1 (en) * | 2004-12-27 | 2007-06-07 | Eisai Research Institute | Sustained release formulations |
AU2005320547B2 (en) * | 2004-12-27 | 2009-02-05 | Eisai R & D Management Co., Ltd. | Method for stabilizing anti-dementia drug |
US20060280789A1 (en) * | 2004-12-27 | 2006-12-14 | Eisai Research Institute | Sustained release formulations |
US20060160852A1 (en) * | 2004-12-27 | 2006-07-20 | Eisai Co. Ltd. | Composition containing anti-dementia drug |
DK1874282T3 (da) | 2005-04-06 | 2010-10-25 | Adamas Pharmaceuticals Inc | Fremgangsmåder og præparater til behandling af CNS lidelser |
WO2006118265A1 (ja) * | 2005-04-28 | 2006-11-09 | Eisai R & D Management Co., Ltd. | 抗痴呆薬を含有する組成物 |
US20060286167A1 (en) * | 2005-05-02 | 2006-12-21 | Jane Staunton | Compositions and methods for the treatment of neurodegenerative diseases |
CA2607600A1 (en) * | 2005-06-16 | 2006-12-28 | Forest Laboratories, Inc. | Modified and immediate release memantine bead formulation |
DK1966611T3 (da) * | 2005-12-23 | 2012-09-10 | Alk Abello As | Fremgangsmåde til opløsningstest af farmaceutiske produkter |
WO2008005534A2 (en) * | 2006-07-06 | 2008-01-10 | Forest Laboratories, Inc. | Orally dissolving formulations of memantine |
US20080067108A1 (en) * | 2006-09-14 | 2008-03-20 | Halliburton Energy Services, Inc. | Methods and compositions for thermally treating a conduit used for hydrocarbon production or transmission to help remove paraffin wax buildup |
GB0623897D0 (en) * | 2006-11-30 | 2007-01-10 | Pliva Istrazivanje I Razvoj D | Pharmaceutical composition of memantine |
US20080182908A1 (en) * | 2007-01-25 | 2008-07-31 | Vinita Umashankar Vyas | Pharmaceutical compositions comprising memantine |
EP2583669A1 (de) | 2007-10-10 | 2013-04-24 | Rubicon Research Private Limited | Im Mund zerfallende Tabletten aus Memantin-Hydrochlorid mit maskiertem Geschmack |
WO2009151498A2 (en) * | 2008-03-28 | 2009-12-17 | Forest Laboratories Holdings Limited | Memantine formulations |
US8741343B2 (en) | 2009-12-02 | 2014-06-03 | Adamas Pharmaceuticals, Inc. | Method of administering amantadine prior to a sleep period |
EP2363119A1 (de) * | 2010-03-05 | 2011-09-07 | Centre Hospitalier Universitaire d'Angers | Neue pharmazeutische Zusammensetzung, die zur Behandlung von Patienten mit neurodegenerativen oder neurovaskulären Erkrankungen geeignet ist |
WO2012101653A2 (en) | 2011-01-25 | 2012-08-02 | Cadila Healthcare Limited | Modified release pharmaceutical compositions memantine |
US20130323309A1 (en) | 2011-02-17 | 2013-12-05 | Lupin Limited | Sustained Release Composition of Memantine |
TR201104108A2 (tr) | 2011-04-27 | 2011-08-22 | Ali̇ Rai̇f İlaç Sanayi̇ A.Ş. | Uzatılmış salımlı memantin tablet. |
FR2980973B1 (fr) * | 2011-10-11 | 2013-11-15 | Univ Clermont Auvergne | Composition pour le traitement prophylactique de la douleur neuropathique. |
US20130274342A1 (en) * | 2012-04-12 | 2013-10-17 | Cerecor, Inc. | Compositions and methods for treating cough |
ES2623176T3 (es) | 2012-08-16 | 2017-07-10 | Teva Pharmaceutical Industries Ltd. | Composición farmacéutica de memantina |
WO2014122077A1 (de) * | 2013-02-08 | 2014-08-14 | Basf Se | Herstellung von anorganisch-organischen kompositmaterialien durch reaktive sprühtrocknung |
US10154971B2 (en) | 2013-06-17 | 2018-12-18 | Adamas Pharma, Llc | Methods of administering amantadine |
WO2019040748A1 (en) | 2017-08-24 | 2019-02-28 | Adamas Pharma, Llc | AMANTADINE COMPOSITIONS, THEIR PREPARATION, AND METHODS OF USE |
US10213393B1 (en) | 2018-02-15 | 2019-02-26 | Osmotica Kereskedelmi és Szolgáltató Korlátolt Feleõsségû Társaság | Composition and method for treating neurological disease |
US10213394B1 (en) | 2018-02-15 | 2019-02-26 | Osmotica Kereskedelmi és Szolgáltató Korlátolt Felelõsségû Társaság | Composition and method for treating neurological disease |
US20190247331A1 (en) | 2018-02-15 | 2019-08-15 | Osmotica Kereskedelmi és Szolgáltató Korlátolt Felelõsségû Társaság | Composition and method for treating neurological disease |
US11602507B2 (en) | 2019-05-27 | 2023-03-14 | Trikona Pharmaceuticals Pvt. Ltd | Extended release oral composition of memantine or its salt and its process for the preparation |
CU20200087A7 (es) | 2020-11-24 | 2022-07-08 | Centro De Neurociencias De Cuba | Composición farmacéutica de derivados de naftaleno como agentes terapéuticos multiblancos para el tratamiento de la enfermedad de alzheimer |
Family Cites Families (21)
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GB715874A (en) * | 1952-10-03 | 1954-09-22 | Horlicks Ltd | A tablet for use in treating peptic ulcers |
GB840091A (en) * | 1955-09-08 | 1960-07-06 | Upjohn Co | Improvements in or relating to therapeutic compositions and the manufacture thereof |
US3594467A (en) * | 1968-10-09 | 1971-07-20 | Richardson Merrell Inc | Long-lasting troche |
ES413944A1 (es) * | 1972-04-20 | 1976-06-01 | Merz & Co | Procedimiento para la preparacion de compuestos de adamen- tano trisustituidos en las posiciones 1,3,5. |
US4076846A (en) * | 1974-11-22 | 1978-02-28 | Sumitomo Bakelite Company Limited | Protein-starch binary molding composition and shaped articles obtained therefor |
US4127650A (en) * | 1975-03-31 | 1978-11-28 | William H. Rorer, Inc. | Medicinal simethicone containing composition and its method of production |
US4419369A (en) * | 1980-09-22 | 1983-12-06 | Baylor College Of Medicine | Protein mineral dietary module |
US4346112A (en) * | 1981-06-29 | 1982-08-24 | University Patents Inc. | Composition and method for treating patients having Parkinson's Disease |
JPS59101423A (ja) * | 1982-12-02 | 1984-06-12 | Takada Seiyaku Kk | 新規なニフエジピン固形製剤 |
US4913906B1 (en) * | 1985-02-28 | 2000-06-06 | Yissum Res Dev Co | Controlled release dosage form of valproic acid |
EP0211294A3 (de) * | 1985-08-06 | 1988-11-17 | Eltech Systems Corporation | Behandlungsmittel für Flüssigkeiten |
US4897380A (en) * | 1985-08-30 | 1990-01-30 | Pollack Robert L | Method and composition for relieving dietary-related disorders |
US4853377A (en) * | 1985-10-15 | 1989-08-01 | Pollack Robert L | Method and composition for increasing production of serotonin |
DK179687D0 (da) * | 1987-04-08 | 1987-04-08 | Farma Food As | Praeparat |
US4792452A (en) * | 1987-07-28 | 1988-12-20 | E. R. Squibb & Sons, Inc. | Controlled release formulation |
US4925677A (en) * | 1988-08-31 | 1990-05-15 | Theratech, Inc. | Biodegradable hydrogel matrices for the controlled release of pharmacologically active agents |
EP0392059B1 (de) * | 1989-04-14 | 1993-09-15 | Merz & Co. GmbH & Co. | Verwendung von Adamantan-Derivaten zur Prävention und Behandlung der cerebralen Ischämie |
JP2571874B2 (ja) * | 1989-11-06 | 1997-01-16 | アルカーメス コントロールド セラピューティクス,インコーポレイテッド | タンパク質マイクロスフェア組成物 |
GB9004950D0 (en) * | 1990-03-06 | 1990-05-02 | Kelco Int Ltd | Controlled release formulation |
AU7991191A (en) * | 1990-05-23 | 1991-12-10 | Southwest Research Institute | Filament system for delivering a medicament and method |
FR2664499B1 (fr) * | 1990-07-16 | 1994-11-04 | Jacques Dubois | Nouvelles formes pharmaceutiques, leur procede de preparation et leurs applications. |
-
1992
- 1992-08-04 DE DE4225730A patent/DE4225730C2/de not_active Expired - Lifetime
-
1993
- 1993-07-23 US US08/096,952 patent/US5382601A/en not_active Expired - Lifetime
- 1993-07-28 EP EP93112018A patent/EP0582186B1/de not_active Expired - Lifetime
- 1993-07-28 ES ES93112018T patent/ES2128369T3/es not_active Expired - Lifetime
- 1993-07-28 DE DE59309388T patent/DE59309388D1/de not_active Expired - Lifetime
- 1993-07-28 DK DK93112018T patent/DK0582186T3/da active
- 1993-07-28 AT AT93112018T patent/ATE176866T1/de active
- 1993-08-03 MX MX9304675A patent/MX9304675A/es unknown
- 1993-08-03 ZA ZA935614A patent/ZA935614B/xx unknown
- 1993-08-03 IL IL106580A patent/IL106580A/en not_active IP Right Cessation
- 1993-08-04 CA CA002141691A patent/CA2141691C/en not_active Expired - Lifetime
- 1993-08-04 AU AU47069/93A patent/AU669731B2/en not_active Expired
- 1993-08-04 LT LTIP839A patent/LT3201B/lt not_active IP Right Cessation
- 1993-08-04 WO PCT/EP1993/002074 patent/WO1994003158A1/en active Application Filing
- 1993-08-04 LV LVP-93-1013A patent/LV10182B/en unknown
- 1993-08-04 CN CN93116211A patent/CN1086708A/zh active Pending
- 1993-08-04 JP JP50501594A patent/JP3560244B2/ja not_active Expired - Fee Related
-
1999
- 1999-05-14 GR GR990401314T patent/GR3030227T3/el unknown
Also Published As
Publication number | Publication date |
---|---|
ES2128369T3 (es) | 1999-05-16 |
US5382601A (en) | 1995-01-17 |
LV10182A (lv) | 1994-10-20 |
CA2141691A1 (en) | 1994-02-17 |
DE4225730A1 (de) | 1994-02-10 |
LV10182B (en) | 1995-04-20 |
JPH07509479A (ja) | 1995-10-19 |
DK0582186T3 (da) | 1999-09-27 |
EP0582186A1 (de) | 1994-02-09 |
CA2141691C (en) | 2002-04-09 |
ATE176866T1 (de) | 1999-03-15 |
ZA935614B (en) | 1995-02-03 |
GR3030227T3 (en) | 1999-08-31 |
AU4706993A (en) | 1994-03-03 |
IL106580A (en) | 1998-02-08 |
AU669731B2 (en) | 1996-06-20 |
LT3201B (en) | 1995-03-27 |
LTIP839A (lt) | 1994-08-25 |
EP0582186B1 (de) | 1999-02-24 |
CN1086708A (zh) | 1994-05-18 |
DE4225730C2 (de) | 2003-04-30 |
IL106580A0 (en) | 1993-12-08 |
JP3560244B2 (ja) | 2004-09-02 |
MX9304675A (es) | 1994-03-31 |
WO1994003158A1 (en) | 1994-02-17 |
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