DE59505789D1 - Pyrimido [5,4-d]pyrimidine, diese verbindungen enthaltende arzneimittel, deren verwendung und verfahren zu ihrer herstellung - Google Patents

Pyrimido [5,4-d]pyrimidine, diese verbindungen enthaltende arzneimittel, deren verwendung und verfahren zu ihrer herstellung

Info

Publication number
DE59505789D1
DE59505789D1 DE59505789T DE59505789T DE59505789D1 DE 59505789 D1 DE59505789 D1 DE 59505789D1 DE 59505789 T DE59505789 T DE 59505789T DE 59505789 T DE59505789 T DE 59505789T DE 59505789 D1 DE59505789 D1 DE 59505789D1
Authority
DE
Germany
Prior art keywords
pyrimido
pyrimidine
compounds
production
products containing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE59505789T
Other languages
English (en)
Inventor
Frank Himmelsbach
Von Thomas Rueden
Georg Dahmann
Thomas Metz
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Boehringer Ingelheim Pharma GmbH and Co KG
Original Assignee
Boehringer Ingelheim Pharma GmbH and Co KG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE4431867A external-priority patent/DE4431867A1/de
Priority claimed from DE1995103151 external-priority patent/DE19503151A1/de
Application filed by Boehringer Ingelheim Pharma GmbH and Co KG filed Critical Boehringer Ingelheim Pharma GmbH and Co KG
Priority to DE59505789T priority Critical patent/DE59505789D1/de
Application granted granted Critical
Publication of DE59505789D1 publication Critical patent/DE59505789D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
DE59505789T 1994-09-07 1995-09-05 Pyrimido [5,4-d]pyrimidine, diese verbindungen enthaltende arzneimittel, deren verwendung und verfahren zu ihrer herstellung Expired - Lifetime DE59505789D1 (de)

Priority Applications (1)

Application Number Priority Date Filing Date Title
DE59505789T DE59505789D1 (de) 1994-09-07 1995-09-05 Pyrimido [5,4-d]pyrimidine, diese verbindungen enthaltende arzneimittel, deren verwendung und verfahren zu ihrer herstellung

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
DE4431867A DE4431867A1 (de) 1994-09-07 1994-09-07 Pyrimido[5,4-d]pyrimidine, diese Verbindungen enthaltende Arzneimittel, deren Verwendung und Verfahren zu ihrer Herstellung
DE1995103151 DE19503151A1 (de) 1995-02-01 1995-02-01 Pyrimido[5,4-d]pyrimidine, diese Verbindungen enthaltende Arzneimittel, deren Verwendung und Verfahren zu ihrer Herstellung
DE1995121386 DE19521386A1 (de) 1995-02-01 1995-06-13 Pyrimido/5,4-d/pyrimidine, diese Verbindungen enthaltende Arzneimittel, deren Verwendung und Verfahren zu ihrer Herstellung
DE1995128672 DE19528672A1 (de) 1995-02-01 1995-08-04 Pyrimido [5,4-d]pyrimidine, diese Verbindungen enthaltende Arzneimittel, deren Verwendung und Verfahren zu ihrer Herstellung
PCT/EP1995/003482 WO1996007657A1 (de) 1994-09-07 1995-09-05 Pyrimido[5,4-d]pyrimidine, diese verbindungen enthaltende arzneimittel, deren verwendung und verfahren zu ihrer herstellung
DE59505789T DE59505789D1 (de) 1994-09-07 1995-09-05 Pyrimido [5,4-d]pyrimidine, diese verbindungen enthaltende arzneimittel, deren verwendung und verfahren zu ihrer herstellung

Publications (1)

Publication Number Publication Date
DE59505789D1 true DE59505789D1 (de) 1999-06-02

Family

ID=27436041

Family Applications (1)

Application Number Title Priority Date Filing Date
DE59505789T Expired - Lifetime DE59505789D1 (de) 1994-09-07 1995-09-05 Pyrimido [5,4-d]pyrimidine, diese verbindungen enthaltende arzneimittel, deren verwendung und verfahren zu ihrer herstellung

Country Status (26)

Country Link
US (1) US5707989A (de)
EP (1) EP0779888B1 (de)
JP (1) JP3184533B2 (de)
CN (1) CN1047778C (de)
AT (1) ATE179420T1 (de)
AU (1) AU688972B2 (de)
BG (1) BG62969B1 (de)
CA (1) CA2199401C (de)
CZ (1) CZ295781B6 (de)
DE (1) DE59505789D1 (de)
DK (1) DK0779888T3 (de)
EE (1) EE9700211A (de)
ES (1) ES2133800T3 (de)
FI (1) FI112947B (de)
GR (1) GR3030589T3 (de)
HK (1) HK1000837A1 (de)
HU (1) HUT77744A (de)
IL (1) IL115185A0 (de)
MX (1) MX9701662A (de)
NO (1) NO307833B1 (de)
NZ (1) NZ292909A (de)
PL (1) PL319042A1 (de)
RO (1) RO120342B1 (de)
SK (1) SK284277B6 (de)
TW (1) TW414798B (de)
WO (1) WO1996007657A1 (de)

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IL112249A (en) * 1994-01-25 2001-11-25 Warner Lambert Co Pharmaceutical compositions containing di and tricyclic pyrimidine derivatives for inhibiting tyrosine kinases of the epidermal growth factor receptor family and some new such compounds
TW321649B (de) * 1994-11-12 1997-12-01 Zeneca Ltd
GB9424233D0 (en) * 1994-11-30 1995-01-18 Zeneca Ltd Quinazoline derivatives
GB9508537D0 (en) * 1995-04-27 1995-06-14 Zeneca Ltd Quinazoline derivatives
GB9508535D0 (en) * 1995-04-27 1995-06-14 Zeneca Ltd Quinazoline derivative
EP0824525B1 (de) * 1995-04-27 2001-06-13 AstraZeneca AB Chinazolin derivate
GB9508565D0 (en) * 1995-04-27 1995-06-14 Zeneca Ltd Quiazoline derivative
GB9624482D0 (en) * 1995-12-18 1997-01-15 Zeneca Phaema S A Chemical compounds
TR199801530T2 (xx) 1996-02-13 1998-11-23 Zeneca Limited VEGF �nhibit�rleri olarak kinazolin t�revleri.
GB9603095D0 (en) * 1996-02-14 1996-04-10 Zeneca Ltd Quinazoline derivatives
GB9603097D0 (en) * 1996-02-14 1996-04-10 Zeneca Ltd Quinazoline compounds
JP4464466B2 (ja) 1996-03-05 2010-05-19 アストラゼネカ・ユーケイ・リミテッド ４―アニリノキナゾリン誘導体
DE19608588A1 (de) * 1996-03-06 1997-09-11 Thomae Gmbh Dr K Pyrimido [5,4-d]pyrimidine, diese Verbindungen enthaltende Arzneimittel, deren Verwendung und Verfahren zu ihrer Herstellung
DE19608653A1 (de) * 1996-03-06 1997-09-11 Thomae Gmbh Dr K Pyrimido[5,4-d]pyrimidine, diese Verbindungen enthaltende Arzneimittel, deren Verwendung und Verfahren zu ihrer Herstellung
DE19613691A1 (de) 1996-04-05 1997-10-09 Boehringer Ingelheim Int Arzneimittel für die Behandlung von Tumorerkrankungen
PL190489B1 (pl) 1996-04-12 2005-12-30 Warner Lambert Co Nieodwracalne inhibitory kinaz tyrozyny, kompozycja farmaceutyczna je zawierająca i ich zastosowanie
GB9607729D0 (en) * 1996-04-13 1996-06-19 Zeneca Ltd Quinazoline derivatives
HRP970371A2 (en) 1996-07-13 1998-08-31 Kathryn Jane Smith Heterocyclic compounds
ES2186908T3 (es) 1996-07-13 2003-05-16 Glaxo Group Ltd Compuestos heterociciclos condensados como inhibidores de pproteina-tirosina-quinasas.
JP3270834B2 (ja) * 1999-01-27 2002-04-02 ファイザー・プロダクツ・インク 抗がん剤として有用なヘテロ芳香族二環式誘導体
UA71945C2 (en) * 1999-01-27 2005-01-17 Pfizer Prod Inc Substituted bicyclic derivatives being used as anticancer agents
UA72946C2 (uk) 1999-11-05 2005-05-16 Астразенека Аб Похідні хіназоліну як інгібітори васкулярного ендотеліального фактора росту (vegf)
CA2416525A1 (en) * 2000-08-09 2002-02-14 Astrazeneca Ab Indole, azaindole and indazole derivatives having vegf inhibiting activity
DE10115921A1 (de) 2001-03-30 2002-10-02 Boehringer Ingelheim Pharma Verfahren zur Herstellung von 4,6-Diaminopyrimido[5,4-d]pyrimidinen
WO2006074147A2 (en) 2005-01-03 2006-07-13 Myriad Genetics, Inc. Nitrogen containing bicyclic compounds and therapeutical use thereof
WO2005003100A2 (en) * 2003-07-03 2005-01-13 Myriad Genetics, Inc. 4-arylamino-quinazolines as activators of caspases and inducers of apoptosis
US8309562B2 (en) 2003-07-03 2012-11-13 Myrexis, Inc. Compounds and therapeutical use thereof
EA013904B1 (ru) 2003-12-18 2010-08-30 Янссен Фармацевтика Н.В. Пиридо- и пиримидопиримидиновые производные в качестве антипролиферативных агентов
NI200700147A (es) 2004-12-08 2019-05-10 Janssen Pharmaceutica Nv Derivados de quinazolina inhibidores de cinasas dirigidos a multip
US8258145B2 (en) 2005-01-03 2012-09-04 Myrexis, Inc. Method of treating brain cancer
EP1976840A1 (de) * 2006-01-13 2008-10-08 F.Hoffmann-La Roche Ag Cyclohexyl-piperazinyl-methanon-derivate und ihre verwendung als histamin-h3-rezeptor-modulatoren
EP2044084B1 (de) 2006-07-13 2016-02-17 Janssen Pharmaceutica NV Mtki-derivate des chinazolins
JP5536647B2 (ja) 2007-07-27 2014-07-02 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ ピロロピリミジン
AR073501A1 (es) * 2008-09-08 2010-11-10 Boehringer Ingelheim Int Derivados de pirimido[5,4-d]pirimidina inhibidores de la tirosinoquinasa
WO2010094695A1 (en) 2009-02-17 2010-08-26 Boehringer Ingelheim International Gmbh Pyrimido [5,4-d] pyrimidine derivatives for the inhibition of tyrosine kinases
CA2772642C (en) 2009-09-03 2017-08-29 Bristol-Myers Squibb Company Quinazolines as potassium ion channel inhibitors
MX345146B (es) * 2010-12-01 2017-01-17 Janssen Pharmaceutica Nv Ciclohexilamino-4-piperidinil-acetamida sustituida en 4 antagonista de ccr2.
US20130023531A1 (en) 2011-01-27 2013-01-24 Boehringer Ingelheim International Gmbh Pyrimido[5,4-d]pyrimidylamino phenyl sulfonamides as serine/threonine kinase inhibitors
CN103339110A (zh) 2011-01-28 2013-10-02 诺瓦提斯公司 作为cdk9抑制剂的取代的杂-联芳基化合物及其用途
ES2638915T3 (es) * 2011-05-20 2017-10-24 Janssen Pharmaceutica, N.V. Procedimiento de preparación de compuestos usados como inhibidores de SGLT-22
WO2014175370A1 (ja) * 2013-04-25 2014-10-30 塩野義製薬株式会社 ピロリジン誘導体およびそれらを含有する医薬組成物
MX2017009571A (es) 2015-01-23 2018-09-27 Aclaris Therapeutics Inc Inhibidores heterociclicos de itk para el tratamiento de la inflamacion y cancer.
CN111868058B (zh) * 2018-05-25 2023-06-13 上海和誉生物医药科技有限公司 一种fgfr抑制剂、其制备方法和在药学上的应用
US11608343B2 (en) * 2020-04-24 2023-03-21 Boehringer Ingelheim International Gmbh Substituted pyrimido[5,4-d]pyrimidines as HER2 inhibitors

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US3031450A (en) * 1959-04-30 1962-04-24 Thomae Gmbh Dr K Substituted pyrimido-[5, 4-d]-pyrimidines
EP0023559B1 (de) * 1979-07-03 1984-09-19 Dr. Karl Thomae GmbH 2-(Perhydro-1,4-diazino)-pyrimido(5,4-d)pyrimidine, ihre Herstellung und diese Verbindungen enthaltenden Arzneimittel
DE3049207A1 (de) * 1980-12-27 1982-07-29 Dr. Karl Thomae Gmbh, 7950 Biberach Neue trisubstituierte pyrimido (5,4-d) pyrimidine, ihre herstellung und ihre verwendung als arzneimittel
DE3423092A1 (de) * 1984-06-22 1986-01-02 Dr. Karl Thomae Gmbh, 7950 Biberach Neue 8-alkylthio-2-piperazino-pyrimido(5,4-d) pyrimidine, ihre herstellung und diese verbindungen enthaltende arzneimittel
US5034393A (en) * 1989-07-27 1991-07-23 Dowelanco Fungicidal use of pyridopyrimidine, pteridine, pyrimidopyrimidine, pyrimidopyridazine, and pyrimido-1,2,4-triazine derivatives
DE4325900A1 (de) * 1993-08-02 1995-02-09 Thomae Gmbh Dr K Trisubstituierte Pyrimido [5,4-d] pyrimidine zur Modulation der Multidrugresistenz, diese Verbindungen enthaltende Arzneimittel und Verfahren zu ihrer Herstellung

Also Published As

Publication number Publication date
MX9701662A (es) 1998-02-28
BG62969B1 (bg) 2000-12-29
JPH10505078A (ja) 1998-05-19
FI112947B (fi) 2004-02-13
NZ292909A (en) 1998-09-24
IL115185A0 (en) 1995-12-31
NO307833B1 (no) 2000-06-05
SK284277B6 (sk) 2004-12-01
WO1996007657A1 (de) 1996-03-14
TW414798B (en) 2000-12-11
CN1047778C (zh) 1999-12-29
CA2199401C (en) 2007-07-10
CA2199401A1 (en) 1996-03-04
NO971038L (no) 1997-05-06
AU3521895A (en) 1996-03-27
RO120342B1 (ro) 2005-12-30
PL319042A1 (en) 1997-07-21
ES2133800T3 (es) 1999-09-16
CZ69197A3 (en) 1997-10-15
HUT77744A (hu) 1998-07-28
AU688972B2 (en) 1998-03-19
ATE179420T1 (de) 1999-05-15
DK0779888T3 (da) 1999-10-25
CN1157619A (zh) 1997-08-20
BG101289A (en) 1997-08-29
US5707989A (en) 1998-01-13
JP3184533B2 (ja) 2001-07-09
EE9700211A (et) 1998-04-15
GR3030589T3 (en) 1999-10-29
SK30297A3 (en) 1997-10-08
NO971038D0 (no) 1997-03-06
HK1000837A1 (en) 2000-11-03
EP0779888B1 (de) 1999-04-28
FI970968A0 (fi) 1997-03-07
EP0779888A1 (de) 1997-06-25
FI970968A (fi) 1997-05-06
CZ295781B6 (cs) 2005-11-16

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Legal Events

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8327 Change in the person/name/address of the patent owner

Owner name: BOEHRINGER INGELHEIM PHARMA GMBH & CO.KG, 55218 IN