DE59510658D1 - Verfahren zur in-vivo-diagnostik mittels nir-strahlung unter verwendung von cyaninfarbstoffen - Google Patents

Verfahren zur in-vivo-diagnostik mittels nir-strahlung unter verwendung von cyaninfarbstoffen

Info

Publication number
DE59510658D1
DE59510658D1 DE59510658T DE59510658T DE59510658D1 DE 59510658 D1 DE59510658 D1 DE 59510658D1 DE 59510658 T DE59510658 T DE 59510658T DE 59510658 T DE59510658 T DE 59510658T DE 59510658 D1 DE59510658 D1 DE 59510658D1
Authority
DE
Germany
Prior art keywords
formula
alkyl
ch2cooh
cooh
dyestuffs
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE59510658T
Other languages
English (en)
Inventor
Kai Licha
Bjoern Riefke
Wolfhard Semmler
Ulrich Speck
Christoph-Stephan Hilger
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer Pharma AG
Original Assignee
Institut fuer Diagnostikforschung GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Institut fuer Diagnostikforschung GmbH filed Critical Institut fuer Diagnostikforschung GmbH
Priority to DE59510658T priority Critical patent/DE59510658D1/de
Application granted granted Critical
Publication of DE59510658D1 publication Critical patent/DE59510658D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0013—Luminescence
    • A61K49/0017—Fluorescence in vivo
    • A61K49/0019—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules
    • A61K49/0021—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules the fluorescent group being a small organic molecule
    • A61K49/0032—Methine dyes, e.g. cyanine dyes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0013—Luminescence
    • A61K49/0017—Fluorescence in vivo
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0013—Luminescence
    • A61K49/0017—Fluorescence in vivo
    • A61K49/0019—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules
    • A61K49/0021—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules the fluorescent group being a small organic molecule
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0013—Luminescence
    • A61K49/0017—Fluorescence in vivo
    • A61K49/005—Fluorescence in vivo characterised by the carrier molecule carrying the fluorescent agent
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
    • C09B23/00—Methine or polymethine dyes, e.g. cyanine dyes
    • C09B23/02—Methine or polymethine dyes, e.g. cyanine dyes the polymethine chain containing an odd number of >CH- or >C[alkyl]- groups
    • C09B23/08—Methine or polymethine dyes, e.g. cyanine dyes the polymethine chain containing an odd number of >CH- or >C[alkyl]- groups more than three >CH- groups, e.g. polycarbocyanines
    • C09B23/086—Methine or polymethine dyes, e.g. cyanine dyes the polymethine chain containing an odd number of >CH- or >C[alkyl]- groups more than three >CH- groups, e.g. polycarbocyanines more than five >CH- groups
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
    • C09B69/00—Dyes not provided for by a single group of this subclass
    • C09B69/10—Polymeric dyes; Reaction products of dyes with monomers or with macromolecular compounds
    • C09B69/105—Polymeric dyes; Reaction products of dyes with monomers or with macromolecular compounds containing a methine or polymethine dye
DE59510658T 1994-12-07 1995-10-10 Verfahren zur in-vivo-diagnostik mittels nir-strahlung unter verwendung von cyaninfarbstoffen Expired - Lifetime DE59510658D1 (de)

Priority Applications (1)

Application Number Priority Date Filing Date Title
DE59510658T DE59510658D1 (de) 1994-12-07 1995-10-10 Verfahren zur in-vivo-diagnostik mittels nir-strahlung unter verwendung von cyaninfarbstoffen

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE4445065A DE4445065A1 (de) 1994-12-07 1994-12-07 Verfahren zur In-vivo-Diagnostik mittels NIR-Strahlung
PCT/DE1995/001465 WO1996017628A1 (de) 1994-12-07 1995-10-10 Verfahren zur in-vivo-diagnostik mittels nir-strahlung
DE59510658T DE59510658D1 (de) 1994-12-07 1995-10-10 Verfahren zur in-vivo-diagnostik mittels nir-strahlung unter verwendung von cyaninfarbstoffen

Publications (1)

Publication Number Publication Date
DE59510658D1 true DE59510658D1 (de) 2003-05-28

Family

ID=6536117

Family Applications (3)

Application Number Title Priority Date Filing Date
DE4445065A Ceased DE4445065A1 (de) 1994-12-07 1994-12-07 Verfahren zur In-vivo-Diagnostik mittels NIR-Strahlung
DE59510982T Expired - Lifetime DE59510982D1 (de) 1994-12-07 1995-10-10 Verfahren zur In-vivo-Diagnostik mittels NIR-Strahlung
DE59510658T Expired - Lifetime DE59510658D1 (de) 1994-12-07 1995-10-10 Verfahren zur in-vivo-diagnostik mittels nir-strahlung unter verwendung von cyaninfarbstoffen

Family Applications Before (2)

Application Number Title Priority Date Filing Date
DE4445065A Ceased DE4445065A1 (de) 1994-12-07 1994-12-07 Verfahren zur In-vivo-Diagnostik mittels NIR-Strahlung
DE59510982T Expired - Lifetime DE59510982D1 (de) 1994-12-07 1995-10-10 Verfahren zur In-vivo-Diagnostik mittels NIR-Strahlung

Country Status (18)

Country Link
US (10) US6083485A (de)
EP (2) EP1181940B1 (de)
JP (4) JPH10510250A (de)
KR (2) KR100340290B1 (de)
CN (1) CN1089008C (de)
AT (2) ATE285254T1 (de)
AU (1) AU709152B2 (de)
CA (1) CA2205906C (de)
DE (3) DE4445065A1 (de)
DK (2) DK0796111T3 (de)
ES (2) ES2236131T3 (de)
HU (1) HUT77378A (de)
IL (4) IL141384A (de)
NO (2) NO319741B1 (de)
NZ (1) NZ294568A (de)
PT (2) PT1181940E (de)
WO (1) WO1996017628A1 (de)
ZA (1) ZA959707B (de)

Families Citing this family (185)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4445065A1 (de) * 1994-12-07 1996-06-13 Diagnostikforschung Inst Verfahren zur In-vivo-Diagnostik mittels NIR-Strahlung
DE19539409C2 (de) * 1995-10-11 1999-02-18 Diagnostikforschung Inst Kontrastmittel für die Nahinfrarot-Diagnostik
US5804389A (en) * 1995-12-29 1998-09-08 Phanos Technologies, Inc. Method for detecting abnormal epithelial cell shedding
US5709845A (en) * 1996-05-13 1998-01-20 Rajagopalan; Raghavan Tricyclic functional dyes for contrast enhancement in optical imaging
US5688966A (en) * 1996-07-26 1997-11-18 E. I. Du Pont De Nemours And Company Compounds and method for synthesizing sulfoindocyanine dyes
DE19649971A1 (de) * 1996-11-19 1998-05-28 Diagnostikforschung Inst Optische Diagnostika zur Diagnostik neurodegenerativer Krankheiten mittels Nahinfrarot-Strahlung (NIR-Strahlung)
US6280703B1 (en) 1997-03-13 2001-08-28 Mallinckrodt Inc. Simultaneous multimodal measurement of physiological function
US6228344B1 (en) 1997-03-13 2001-05-08 Mallinckrodt Inc. Method of measuring physiological function
DE19717904A1 (de) * 1997-04-23 1998-10-29 Diagnostikforschung Inst Säurelabile und enzymatisch spaltbare Farbstoffkonstrukte zur Diagnostik mit Nahinfrarotlicht und zur Therapie
GB9712524D0 (en) * 1997-06-16 1997-08-20 Nycomed Imaging As Method
CA2303138C (fr) * 1997-09-12 2009-06-30 Communaute Europeenne Detection et cartographie de zones enflammees de tissus vivants
WO1999013916A2 (en) * 1997-09-18 1999-03-25 Nycomed Imaging As Methods and compositions for medical imaging
US6133445A (en) * 1997-12-17 2000-10-17 Carnegie Mellon University Rigidized trimethine cyanine dyes
US6685895B1 (en) 1997-12-17 2004-02-03 Ethicon, Inc. Method and apparatus for processing device with reduced occlusion
US6645430B1 (en) 1997-12-17 2003-11-11 Ethicon, Inc. Method and apparatus for processing device with fluid submersion
US6596232B1 (en) 1997-12-17 2003-07-22 Ethicon, Inc. Device processing apparatus and method having positive pressure with two partitions to minimize leakage
JP4560209B2 (ja) * 1998-04-03 2010-10-13 マリンクロッド・インコーポレイテッド 診断および治療に有用な非共有結合的バイオコンジュゲート
US20030235846A1 (en) * 1998-04-08 2003-12-25 Terpetschnig Ewald A. Luminescent compounds
US7250517B2 (en) * 1998-04-08 2007-07-31 Ewald A. Terpetschnig Luminescent compounds
US7411068B2 (en) * 1998-04-08 2008-08-12 Terpetschnig Ewald A Luminescent compounds
US20030176663A1 (en) * 1998-05-11 2003-09-18 Eidgenossische Technische Hochscule Specific binding molecules for scintigraphy
US6592847B1 (en) 1998-05-14 2003-07-15 The General Hospital Corporation Intramolecularly-quenched near infrared flourescent probes
US6083486A (en) * 1998-05-14 2000-07-04 The General Hospital Corporation Intramolecularly-quenched near infrared fluorescent probes
US7547721B1 (en) 1998-09-18 2009-06-16 Bayer Schering Pharma Ag Near infrared fluorescent contrast agent and fluorescence imaging
US20030180221A1 (en) * 1998-09-18 2003-09-25 Schering Ag Near infrared fluorescent contrast agent and fluorescence imaging
JP2000095758A (ja) * 1998-09-18 2000-04-04 Schering Ag 近赤外蛍光造影剤および蛍光造影方法
US6299860B1 (en) 1998-10-15 2001-10-09 Fluoro Probe, Inc. Method for viewing diseased tissue located within a body cavity
US6652836B2 (en) 1998-10-15 2003-11-25 Fluoroprobe, Inc. Method for viewing tumor tissue located within a body cavity
US6284223B1 (en) * 1998-10-15 2001-09-04 Fluoroprobe, Inc. Method for viewing tumor tissue located within a body cavity
SE9804328D0 (sv) * 1998-12-15 1998-12-15 Christer Busch Contrast agent for facilitating ocular identification and inspection of lymph nodes
ATE234114T1 (de) * 1999-01-15 2003-03-15 Light Sciences Corp Therapeutische zusammensetzungen fur knochenstoffwechselstörungen oder knochenmetastasen enthaltend einen photosensitizer und ein bisphosphonat
US6602274B1 (en) 1999-01-15 2003-08-05 Light Sciences Corporation Targeted transcutaneous cancer therapy
JP2002534218A (ja) * 1999-01-15 2002-10-15 ライト サイエンシーズ コーポレイション 非侵襲性の脈管療法
WO2000047112A1 (fr) * 1999-02-12 2000-08-17 Alexei Ivanovich Trushin Procede de diagnostic de regions de proliferation et dispositif de mise en oeuvre de ce procede
DE19917713A1 (de) * 1999-04-09 2000-10-19 Diagnostikforschung Inst Kurzkettige Peptid-Farbstoffkonjugate als Konstrastmittel für die optische Diagnostik
US6217848B1 (en) * 1999-05-20 2001-04-17 Mallinckrodt Inc. Cyanine and indocyanine dye bioconjugates for biomedical applications
US20030114434A1 (en) * 1999-08-31 2003-06-19 James Chen Extended duration light activated cancer therapy
DE19948650A1 (de) * 1999-09-29 2001-07-19 Diagnostikforschung Inst Galenische Formulierungen
CA2395567A1 (en) * 2000-01-12 2001-07-19 Light Sciences Corporation Novel treatment for eye disease
US6180087B1 (en) 2000-01-18 2001-01-30 Mallinckrodt Inc. Tunable indocyanine dyes for biomedical applications
US7790144B2 (en) * 2000-01-18 2010-09-07 Mallinckrodt Inc. Receptor-avid exogenous optical contrast and therapeutic agents
US6939532B2 (en) 2000-01-18 2005-09-06 Mallinckrodt, Inc. Versatile hydrophilic dyes
US6395257B1 (en) 2000-01-18 2002-05-28 Mallinckrodt Inc. Dendrimer precursor dyes for imaging
US6180086B1 (en) * 2000-01-18 2001-01-30 Mallinckrodt Inc. Hydrophilic cyanine dyes
US20080233050A1 (en) * 2000-01-18 2008-09-25 Mallinckrodt Inc. Diagnostic and therapeutic optical agents
US7198778B2 (en) 2000-01-18 2007-04-03 Mallinckrodt Inc. Tumor-targeted optical contrast agents
CA2400622A1 (en) * 2000-02-24 2001-08-30 Eidgenossische Technische Hochschule Zurich Antibody specific for the ed-b domain of fibronectin, conjugates comprising said antibody, and their use for the detection and treatment of angiogenesis
US7575761B2 (en) * 2000-06-30 2009-08-18 Novartis Pharma Ag Spray drying process control of drying kinetics
ES2312478T3 (es) * 2000-09-07 2009-03-01 Bayer Schering Pharma Aktiengesellschaft Receptor del dominio edb de fibronectina (ii).
DE10046215B4 (de) * 2000-09-19 2004-04-15 Institut für Chemo- und Biosensorik Münster e.V. i.Ins. Fluorochrome und deren Verwendung
DE60116510T2 (de) * 2000-09-19 2006-07-13 Li-Cor, Inc., Lincoln Cyaninfarbstoffe
US7597878B2 (en) * 2000-09-19 2009-10-06 Li-Cor, Inc. Optical fluorescent imaging
NO20004795D0 (no) 2000-09-26 2000-09-26 Nycomed Imaging As Peptidbaserte forbindelser
DE20122672U1 (de) * 2000-09-29 2007-04-05 Molecular Probes, Inc., Eugene Modifizierte Carbocyaninfarbstoffe und deren Konjugate
DE60126297T2 (de) * 2000-09-29 2007-11-15 Molecular Probes, Inc., Eugene Modifizierte carbocyaninfarbstoffe und deren konjugate
US6663847B1 (en) * 2000-10-13 2003-12-16 Mallinckrodt Inc. Dynamic organ function monitoring agents
US6669926B1 (en) * 2000-10-16 2003-12-30 Mallinckrodt, Inc. Hydrophilic light absorbing indole compounds for determination of physiological function in critically ill patients
US6656451B1 (en) * 2000-10-16 2003-12-02 Mallinckrodt, Inc. Indole compounds as novel dyes for organ function monitoring
US6733744B1 (en) * 2000-10-16 2004-05-11 Mallinckrodt Inc. Indole compounds as minimally invasive physiological function monitoring agents
US20070092450A1 (en) * 2000-10-16 2007-04-26 Mallinckrodt Inc. Tissue-specific exogenous optical agents
US20040180809A1 (en) * 2000-10-16 2004-09-16 Mallinckrodt Inc. Tissue-specific exogenous optical agents
US6716413B1 (en) * 2000-10-16 2004-04-06 Mallinckrodt, Inc. Indole compounds as tissue-specific exogenous optical agents
US7556797B2 (en) 2000-10-16 2009-07-07 Mallinckrodt Inc. Minimally invasive physiological function monitoring agents
US6673334B1 (en) * 2000-10-16 2004-01-06 Mallinkcrodt, Inc. Light sensitive compounds for instant determination of organ function
EP1341557A2 (de) 2000-10-27 2003-09-10 Beth Israel Deaconess Medical Center Nichtisotopischer nachweis von osteoblastischer aktivität in vivo mittels modifizierten bisphosphonaten
US7383076B2 (en) * 2000-11-27 2008-06-03 The General Hospital Corporation Fluorescence-mediated molecular tomography
US6984373B2 (en) 2000-12-23 2006-01-10 Dyax Corp. Fibrin binding moieties useful as imaging agents
US20030044353A1 (en) * 2001-01-05 2003-03-06 Ralph Weissleder Activatable imaging probes
AU2006200164B2 (en) * 2001-04-09 2007-03-08 Oncofluor, Inc. Method for viewing tumor tissue located within a body cavity
US20030031627A1 (en) * 2001-07-31 2003-02-13 Mallinckrodt Inc. Internal image antibodies for optical imaging and therapy
US20030105300A1 (en) 2001-10-17 2003-06-05 Mallinckrodt Inc. Tumor targeted photodiagnostic-phototherapeutic agents
US6761878B2 (en) 2001-10-17 2004-07-13 Mallinckrodt, Inc. Pathological tissue detection and treatment employing targeted benzoindole optical agents
US20030152577A1 (en) * 2002-02-07 2003-08-14 Mallinckrodt Inc. Dye-bioconjugates for simultaneous optical diagnostic and therapeutic applications
US7794693B2 (en) 2002-03-01 2010-09-14 Bracco International B.V. Targeting vector-phospholipid conjugates
CA2513044A1 (en) 2002-03-01 2004-08-05 Dyax Corp. Kdr and vegf/kdr binding peptides and their use in diagnosis and therapy
US8623822B2 (en) 2002-03-01 2014-01-07 Bracco Suisse Sa KDR and VEGF/KDR binding peptides and their use in diagnosis and therapy
ES2506142T3 (es) 2002-03-01 2014-10-13 Dyax Corp. Péptidos de unión a KDR y a VEGF/KDR y su uso en diagnóstico
US7261876B2 (en) 2002-03-01 2007-08-28 Bracco International Bv Multivalent constructs for therapeutic and diagnostic applications
AU2003248900A1 (en) * 2002-07-12 2004-02-02 Beth Israel Deaconess Medical Center Conjugated infrared fluorescent substances for detection of cell death
US20040132092A1 (en) * 2003-01-03 2004-07-08 Stetson Christopher M. Determining the density of functional moieties on polymer reagents
US7226577B2 (en) 2003-01-13 2007-06-05 Bracco Imaging, S. P. A. Gastrin releasing peptide compounds
WO2004065491A1 (en) * 2003-01-24 2004-08-05 Schering Ag Hydrophilic, thiol-reactive cyanine dyes and conjugates thereof with biomolecules for fluorescence diagnosis
PT2949658T (pt) 2003-03-03 2018-10-18 Bracco Suisse Sa Péptidos que ligam especificamente o recetor de hgf (cmet) e utilizações dos mesmos
US7850946B2 (en) 2003-05-31 2010-12-14 Washington University In St. Louis Macrocyclic cyanine and indocyanine bioconjugates provide improved biomedical applications
US7803624B2 (en) * 2003-09-30 2010-09-28 Cytyc Corporation Automated cytological sample classification
ES2372395T3 (es) 2003-10-31 2012-01-19 Ge Healthcare Limited Reactivos de marcado con colorantes de cianina.
WO2005082423A2 (en) * 2003-11-18 2005-09-09 Beth Israel Deaconess Medical Center Serum albumin conjugated to fluorescent substances for imaging
JP2005145921A (ja) * 2003-11-19 2005-06-09 Konica Minolta Medical & Graphic Inc 診断用蛍光造影剤及び蛍光造影診断方法
JP2005170812A (ja) * 2003-12-09 2005-06-30 Konica Minolta Medical & Graphic Inc 蛍光造影剤及び蛍光造影方法
US7682602B2 (en) * 2003-12-19 2010-03-23 Konica Minolta Medical & Graphic, Inc. Near-infrared fluorescent contrast medium
JP4487180B2 (ja) * 2004-03-18 2010-06-23 ソニー株式会社 情報生成装置及び情報生成方法
ES2376557T3 (es) * 2004-06-16 2012-03-14 Ge Healthcare As Compuestos basados en péptidos.
WO2006047452A2 (en) * 2004-10-25 2006-05-04 Anaspec, Inc. Reactive 1,3’-crosslinked carbocyanines and their bioconjugates
ITMI20050328A1 (it) 2005-03-03 2006-09-04 Univ Degli Studi Milano Composti peptidomimetrici e preparazione di derivati biologicamente attivi
US20100055040A1 (en) * 2005-06-21 2010-03-04 Periasamy Muthunadar P Optical Imaging Contrast Agents
US8227621B2 (en) * 2005-06-30 2012-07-24 Li-Cor, Inc. Cyanine dyes and methods of use
AU2006284565B2 (en) * 2005-09-02 2013-05-30 Visen Medical, Inc. Biocompatible N, N-disubstituted sulfonamide-containing fluorescent dye labels
US8173819B2 (en) * 2005-09-02 2012-05-08 Visen Medical, Inc. Nicotinic and picolinic acid derived near-infrared fluorophores
EP1937676B1 (de) * 2005-09-02 2016-11-30 Visen Medical, Inc. Biologisch kompatible, fluoreszente mittel zur bilddarstellung
DE102006029454A1 (de) 2005-12-05 2007-06-06 Dyomics Gmbh Hydrophile Marker auf Basis von diasteromeren
EP1792949B1 (de) * 2005-12-05 2010-09-08 Dyomics GmbH Hydrophile Marker auf der Basis von diastereomeren Cyaninen
EP1973575B1 (de) 2005-12-22 2019-07-24 Visen Medical, Inc. Biokompatibele fluoreszierende metalloxide nanopartikel
US20070148094A1 (en) * 2005-12-22 2007-06-28 Uzgiris Egidijus E Polymeric imaging agents and medical imaging methods
US20070179094A1 (en) 2006-01-31 2007-08-02 Bayer Schering Pharma Ag Modulation of MDL-1 activity for treatment of inflammatory disease
EP1815870A1 (de) * 2006-02-01 2007-08-08 DKFZ Deutsches Krebsforschungszentrum Mit Metalchelaten verbundene Cyaninfarbstoffe zur bimodalen darstellenden Diagnose
WO2007097318A1 (ja) * 2006-02-23 2007-08-30 Adeka Corporation 診断用マーカー
US20100022449A1 (en) * 2006-03-09 2010-01-28 Mallinckrodt Inc. Receptor-avid exogenous optical contrast and therapeutic agents
ATE535525T1 (de) 2006-03-31 2011-12-15 Wako Pure Chem Ind Ltd Cyaninfarbstoff vom pyrazoltyp
US20070281363A1 (en) * 2006-04-13 2007-12-06 Ewald Terpetschnig Luminescent compounds
US20080076188A1 (en) * 2006-06-19 2008-03-27 Patsenker Leonid D Luminescent compounds
US7993927B2 (en) 2006-07-03 2011-08-09 Beth Israel Deaconess Medical Center, Inc. Histology methods
US8155730B2 (en) 2006-10-24 2012-04-10 The Research Foundation Of State University Of New York Composition, method, system, and kit for optical electrophysiology
WO2008071679A1 (en) 2006-12-11 2008-06-19 Bracco Imaging Spa Fibrin binding peptide conjugates for diagnostic and therapeutic applications.
DE102007002726A1 (de) * 2007-01-18 2008-07-31 Bayer Schering Pharma Aktiengesellschaft Neue Kaskaden-Polymer-Komplexe, Verfahren zu ihrer Herstellung und diese enthaltende pharmazeutische Mittel
WO2008094637A2 (en) 2007-01-30 2008-08-07 Seta Biomedicals. Llc Luminescent compounds
JP5476989B2 (ja) 2007-01-31 2014-04-23 和光純薬工業株式会社 ゲノムｄｎａ断片の増幅または欠失の検出方法
US8221721B2 (en) * 2007-02-09 2012-07-17 Visen Medical, Inc. Polycyclo dyes and use thereof
WO2008109832A2 (en) * 2007-03-08 2008-09-12 Visen Medical, Inc. Viable near-infrared fluorochrome labeled cells and methods of making and using same
JP2008261784A (ja) * 2007-04-13 2008-10-30 Olympus Corp 生体観察方法
EP2005970A1 (de) 2007-06-22 2008-12-24 Berlin Science Partners GmbH i.V. Bildgebende Diagnostik durch Kombination von Kontrastmitteln
WO2009039207A1 (en) 2007-09-19 2009-03-26 Oncofluor, Inc. Method for imaging and treating organs and tissues
DE102007059752A1 (de) 2007-12-10 2009-06-18 Bayer Schering Pharma Aktiengesellschaft Funktionalisierte, feste Polymernanopartikel enthaltend Epothilone
EP2223086B2 (de) * 2007-12-14 2016-06-01 Biotium Inc. Fluoreszenzverbindungen - markierungsfarbstoffe
US8253725B2 (en) * 2007-12-28 2012-08-28 St. Jude Medical, Atrial Fibrillation Division, Inc. Method and system for generating surface models of geometric structures
EP3320923B1 (de) 2008-01-18 2022-04-06 Visen Medical, Inc. Fluoreszierende bildgebungsmittel
US20090214436A1 (en) 2008-02-18 2009-08-27 Washington University Dichromic fluorescent compounds
EP2248821B8 (de) 2008-02-22 2015-03-18 Wako Pure Chemical Industries, Ltd. Substrat zur überprüfung von beta-glucan und/oder endotoxinen und entsprechendes prüfverfahren
EP2147684A1 (de) 2008-07-22 2010-01-27 Bracco Imaging S.p.A Selektiv gegen Metallproteasen wirkende Diagnosemittel
US7951959B2 (en) 2008-09-17 2011-05-31 Thermo Fisher Scientific (Milwaukee) LLC Hydrophilic labels for biomolecules
EP2362884B1 (de) * 2008-10-27 2017-08-02 Sony Corporation Farbstoff an dessen chromophor eine acyloingruppe gebunden ist
JP2012509300A (ja) * 2008-11-20 2012-04-19 ジーイー・ヘルスケア・アクスイェ・セルスカプ 色素コンジュゲートイメージング剤
US8864821B2 (en) * 2008-11-26 2014-10-21 Visen Medical, Inc. Methods and compositions for identifying subjects at risk of developing stent thrombosis
US20100143258A1 (en) * 2008-12-05 2010-06-10 General Electric Company Tumor margin imaging agents
GB0823315D0 (en) 2008-12-22 2009-01-28 Ge Healthcare As Fluorescent Probes
JP5500875B2 (ja) * 2009-01-30 2014-05-21 キヤノン株式会社 新規化合物、該新規化合物を用いたプローブ及び該新規化合物もしくは該プローブを用いた蛍光イメージング用造影剤
CA2755770A1 (en) 2009-03-19 2010-09-23 General Electric Company Optical imaging agents
CN102459469A (zh) * 2009-04-17 2012-05-16 利康股份有限公司 用取代的花青染料进行荧光成像
AU2010286592B2 (en) 2009-08-28 2015-08-13 Visen Medical, Inc. Systems and methods for tomographic imaging in diffuse media using a hybrid inversion technique
CA2810822C (en) 2009-09-22 2018-03-06 Visen Medical, Inc. Systems and methods for virtual index-matching of diffusive media
DE102010022110A1 (de) * 2010-05-31 2011-12-01 LMU Universität München Department Chemie Cyaninfarbstoffe als Kontrastmittel zur Unterstützung der Augenchirurgie
US8623324B2 (en) 2010-07-21 2014-01-07 Aat Bioquest Inc. Luminescent dyes with a water-soluble intramolecular bridge and their biological conjugates
EP2598174B1 (de) * 2010-07-30 2019-03-27 SmartDyeLivery GmbH Messverfahren zur bestimmung einer organfunktion
GB201015806D0 (en) 2010-09-21 2010-10-27 Ge Healthcare As Vascular imaging agents
WO2012054749A1 (en) 2010-10-20 2012-04-26 Li-Cor, Inc. Cyanine dyes and their conjugates
EP3029027B1 (de) 2010-12-21 2018-06-27 Pierce Biotechnology, Inc. Fluoreszierende verbindungen
US10221159B2 (en) 2011-05-09 2019-03-05 Visen Medical, Inc. Carbonic anhydrase targeting agents and methods of using same
US8889884B1 (en) 2011-07-14 2014-11-18 Pierce Biotechnology, Inc. Phosphine derivatives of fluorescent compounds
US9249307B2 (en) 2011-08-16 2016-02-02 Pierce Biotechnology, Inc. Benzocyanine compounds
GB201116733D0 (en) 2011-09-28 2011-11-09 Ge Healthcare As Peptide margin imaging agents
EP3338617B1 (de) 2012-01-23 2020-08-19 Washington University Brillenbildgebungssysteme und- vorrichtungen
US9751868B2 (en) 2012-02-28 2017-09-05 Pierce Biotechnology, Inc. Benzocyanine compounds
US20140072515A9 (en) 2012-03-02 2014-03-13 Greg Hermanson Cyanine compounds
CN104204203A (zh) 2012-03-22 2014-12-10 和光纯药工业株式会社 具有微卫星区域的dna的检测方法
AU2013236175A1 (en) 2012-03-22 2014-10-16 Kanagawa Prefectural Hospital Organization Method for identification and detection of mutant gene using intercalator
EP2831264B1 (de) 2012-03-30 2019-07-10 VisEn Medical, Inc. Bakterielle bildgebungsmittel und verfahren zur verwendung davon
WO2013152395A1 (en) * 2012-04-13 2013-10-17 Baker Idi Heart & Diabetes Institute Holdings Limited Atherosclerotic plaque detection
US9592307B2 (en) 2012-07-20 2017-03-14 Canon Kabushiki Kaisha Compound and photoacoustic imaging contrast medium containing the compound
CA2882019C (en) 2012-08-15 2021-02-09 Visen Medical, Inc. Prostate specific antigen agents and methods of using same for prostate cancer imaging
CN104540819B (zh) 2012-08-28 2019-04-19 皮尔斯生物科技有限公司 苯并吡喃鎓化合物
WO2014062716A1 (en) 2012-10-15 2014-04-24 Visen Medical, Inc. Systems, methods, and apparatus for imaging of diffuse media featuring cross-modality weighting of fluorescent and bioluminescent sources
CA2901379C (en) 2013-03-15 2023-05-16 Visen Medical, Inc. Substituted silaxanthenium red to near-infrared fluorochromes for in vitro and in vivo imaging and detection
CN105050614B (zh) 2013-03-15 2019-04-05 加利福尼亚大学董事会 刺激胆固醇流出的具有降低的毒性的肽
EP2970674B1 (de) 2013-03-15 2018-12-12 VisEn Medical, Inc. 4,4-disubstituierte cyclohexyl-verbrückte heptamethin-cyanin-farbstoffe und verwendungen davon
US9353092B2 (en) 2013-06-27 2016-05-31 University Of Notre Dame Du Lac Synthesis and use of croconaine compounds
WO2015038968A1 (en) 2013-09-13 2015-03-19 The General Hospital Corporation Activatable fibrin-binding probes
SG10201804505VA (en) 2013-10-31 2018-07-30 Beth Israel Deaconess Medical Ct Inc Near-infrared fluorescent contrast bioimaging agents and methods of use thereof
US11001562B2 (en) 2013-10-31 2021-05-11 Beth Israel Deaconess Medical Center Near-infrared fluorescent nerve contrast agents and methods of use thereof
US10022189B2 (en) 2013-12-16 2018-07-17 Stryker Sustainability Solutions, Inc. Apparatus and method for cleaning an instrument
CN106455979A (zh) 2013-12-31 2017-02-22 纪念斯隆-凯特琳癌症中心 用于荧光源实时多通道成像的系统、方法和设备
KR20150145468A (ko) 2014-06-19 2015-12-30 김영미 숯 성형물의 제조방법 및 이에 의해 제조된 숯 성형물
UA109751C2 (uk) * 2014-09-26 2015-09-25 Спосіб визначення гідрогелю в біологічних тканинах
AU2015362663B2 (en) 2014-12-15 2020-07-09 Cornell University Cyclic peptides with enhanced nerve-binding selectivity, nanoparticles bound with said cyclic peptides, and use of same for real-time in vivo nerve tissue imaging
WO2016179350A1 (en) 2015-05-06 2016-11-10 Washington University Compounds having rd targeting motifs and methods of use thereof
US9670318B2 (en) 2015-05-28 2017-06-06 Miltenyi Biotec Gmbh Bright fluorochromes based on multimerization of fluorescent dyes
EP3098269B1 (de) 2015-05-28 2022-04-06 Miltenyi Biotec B.V. & Co. KG Auf der multimerisierung von fluoreszenzfarbstoffen auf verzweigten polyethergerüsten basierende helle fluorchrome
WO2017106525A1 (en) 2015-12-15 2017-06-22 Memorial Sloan Kettering Cancer Center Imaging systems and methods for tissue differentiation, e.g., for intraoperative visualization
US20190137396A1 (en) * 2016-04-28 2019-05-09 National University Corporation Nagoya University Fluorescent probe, method for detecting fluorescence, and method for using fluorescent probe
KR101855395B1 (ko) * 2016-09-26 2018-05-09 부경대학교 산학협력단 근적외선을 이용한 폐종양 스크리닝 방법
CN110167601A (zh) 2016-11-30 2019-08-23 纪念斯隆凯特琳癌症中心 抑制剂-功能化超微小纳米粒子和其方法
EP3412303A1 (de) 2017-06-08 2018-12-12 Medizinische Universität Innsbruck Verbessertes pharmakokinetik- und cholecystokinin-2-rezeptor (cck2r)-zielverfahren für diagnose und therapie
US11091646B2 (en) 2017-08-14 2021-08-17 Seta Biomedicals, Llc Luminescent squaraine rotaxane compounds
PL3969063T3 (pl) 2019-05-13 2024-03-04 Bracco Imaging Spa Modyfikowane barwniki cyjaninowe i ich koniugaty
KR20210069945A (ko) 2019-12-04 2021-06-14 삼성전자주식회사 생체정보 추산 장치 및 방법
EP4072598A4 (de) 2019-12-13 2024-02-21 Washington University St Louis Nahinfrarot-fluoreszierende farbstoffe, formulierungen und zugehörige verfahren
EP4015004A1 (de) 2020-12-18 2022-06-22 Phi Pharma SA Proteoglykanspezifische verzweigte peptide

Family Cites Families (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1522421A1 (de) * 1967-01-17 1969-07-31 Agfa Gevaert Ag Optisch sensibilisiertes lichtempfindliches Material
JPS5552750A (en) * 1978-10-12 1980-04-17 Mochida Pharm Co Ltd Laser knife* which can be detected* of tumor portion
JPS55116259A (en) * 1979-03-01 1980-09-06 Fuji Photo Film Co Ltd Microimmunoassay method
US4541438A (en) * 1983-06-02 1985-09-17 The Johns Hopkins University Localization of cancerous tissue by monitoring infrared fluorescence emitted by intravenously injected porphyrin tumor-specific markers excited by long wavelength light
AU641361B2 (en) * 1988-05-02 1993-09-23 Zynaxis Technologies, Incorporated Compounds, compositions and method for binding bio-affecting substances to surface membranes of bio-particles
DE3828360A1 (de) * 1988-08-20 1990-02-22 Stanowsky Alexander Dr Farbstoff-markierter antitumor-antikoerper und verfahren zu seiner herstellung
DE3912046B4 (de) * 1988-09-02 2004-03-25 Carnegie Mellon University Verfahren zum Markieren einer Komponente einer wäßrigen Flüssigkeit und lumineszenzphotostabiles Reaktionsprodukt
US5153112A (en) * 1988-09-05 1992-10-06 Konica Corporation Method of processing silver halide photographic materials
SE8900612D0 (sv) * 1989-02-22 1989-02-22 Jonas Johansson Vaevnadskarakterisering utnyttjande ett blodfritt fluorescenskriterium
US4945239A (en) * 1989-03-29 1990-07-31 Center For Innovative Technology Early detection of breast cancer using transillumination
US5098379A (en) * 1990-01-10 1992-03-24 Rochester Medical Corporation Catheter having lubricated outer sleeve and methods for making and using same
ATE206395T1 (de) * 1990-05-15 2001-10-15 Hyperion Inc Fluoreszierende porphyrin- und fluoreszierende phthalocyanin-polyethylenglykol-, polyol- und saccharidderivate als fluoreszierende sonden
US5880287A (en) * 1990-05-15 1999-03-09 Hyperion, Inc. Polyoxyhydrocarbyl related products and methods for fluorescence assays
WO1992000748A1 (en) * 1990-07-06 1992-01-23 Enzon, Inc. Poly(alkylene oxide) amino acid copolymers and drug carriers and charged copolymers based thereon
DE4136769A1 (de) * 1991-11-05 1993-05-06 Humboldt-Universitaet Zu Berlin, O-1086 Berlin, De Verfahren zum diagnostizieren von mit fluoreszierenden substanzen angereicherten, insbesondere tumoroesen gewebebereichen
US5298379A (en) 1992-06-30 1994-03-29 Eastman Kodak Company Radiation sensitive element with absorber dye to enhance spectral sensitivity range
DE4323368C2 (de) * 1993-07-13 1998-01-15 Domschke Wolfram Verwendung einer Markersubstanz zur Unterscheidung von verändertem Gewebe in einer Umgebung von unverändertem Gewebe
US6238931B1 (en) * 1993-09-24 2001-05-29 Biosite Diagnostics, Inc. Fluorescence energy transfer in particles
DE4445065A1 (de) 1994-12-07 1996-06-13 Diagnostikforschung Inst Verfahren zur In-vivo-Diagnostik mittels NIR-Strahlung
DE19539409C2 (de) * 1995-10-11 1999-02-18 Diagnostikforschung Inst Kontrastmittel für die Nahinfrarot-Diagnostik
AU716233B2 (en) * 1996-01-16 2000-02-24 Lumigen, Inc. Compounds, compositions and methods for generating chemiluminescence with phosphatase enzymes
DE19649971A1 (de) * 1996-11-19 1998-05-28 Diagnostikforschung Inst Optische Diagnostika zur Diagnostik neurodegenerativer Krankheiten mittels Nahinfrarot-Strahlung (NIR-Strahlung)
DE19717904A1 (de) * 1997-04-23 1998-10-29 Diagnostikforschung Inst Säurelabile und enzymatisch spaltbare Farbstoffkonstrukte zur Diagnostik mit Nahinfrarotlicht und zur Therapie
US7175953B2 (en) * 1999-04-09 2007-02-13 Institute Fuer Diagnostik Forschung Short-warp peptide-dye conjugate as contrast agent for optical diagnostic
US6630570B1 (en) * 1999-04-09 2003-10-07 Insitut für Diagnostikforschung GmbH Short-chain peptide-dye conjugates as contrast media for optical diagnosis
EP1088559A3 (de) * 1999-09-29 2002-10-02 INSTITUT FÜR DIAGNOSTIKFORSCHUNG GmbH AN DER FREIEN UNIVERSITÄT BERLIN Galenische Formulierungen
JP2003261464A (ja) * 2002-03-07 2003-09-16 Fuji Photo Film Co Ltd 近赤外蛍光造影剤および蛍光造影法
US20060239916A1 (en) * 2005-01-07 2006-10-26 Kai Licha Use of cyanine dyes for the diagnosis of proliferative diseases
EP1743658A1 (de) * 2005-07-14 2007-01-17 Schering Aktiengesellschaft Optische Bilderherstellung von rheumatischer Arthritis

Also Published As

Publication number Publication date
AU709152B2 (en) 1999-08-19
US20100129293A1 (en) 2010-05-27
EP0796111B1 (de) 2003-04-23
IL141384A0 (en) 2002-03-10
NZ294568A (en) 1999-08-30
CN1174511A (zh) 1998-02-25
JP3836687B2 (ja) 2006-10-25
CN1089008C (zh) 2002-08-14
DK1181940T3 (da) 2005-04-18
DK0796111T3 (da) 2003-08-11
US6258340B1 (en) 2001-07-10
US20010055567A1 (en) 2001-12-27
IL153745A0 (en) 2003-07-06
JP2010065036A (ja) 2010-03-25
JP2002012782A (ja) 2002-01-15
DE4445065A1 (de) 1996-06-13
US6926885B2 (en) 2005-08-09
ATE238071T1 (de) 2003-05-15
EP1181940A2 (de) 2002-02-27
HUT77378A (hu) 1998-04-28
US20050169844A1 (en) 2005-08-04
ATE285254T1 (de) 2005-01-15
PT1181940E (pt) 2005-04-29
PT796111E (pt) 2003-09-30
EP0796111A1 (de) 1997-09-24
JPH10510250A (ja) 1998-10-06
US7655217B2 (en) 2010-02-02
DE59510982D1 (de) 2005-01-27
KR980700091A (ko) 1998-03-30
ES2236131T3 (es) 2005-07-16
US20060165599A1 (en) 2006-07-27
US7445767B2 (en) 2008-11-04
US20050106106A1 (en) 2005-05-19
US20060165598A1 (en) 2006-07-27
US20030026763A1 (en) 2003-02-06
AU3740995A (en) 1996-06-26
NO20053239L (no) 1997-06-02
US7025949B2 (en) 2006-04-11
WO1996017628A1 (de) 1996-06-13
NO20053239D0 (no) 2005-07-01
NO319741B1 (no) 2005-09-12
IL116018A0 (en) 1996-01-31
CA2205906A1 (en) 1996-06-13
EP1181940A3 (de) 2002-03-13
CA2205906C (en) 2006-10-03
NO972509L (no) 1997-06-02
NO972509D0 (no) 1997-06-02
KR100312939B1 (ko) 2002-02-28
JP2005232190A (ja) 2005-09-02
US6083485A (en) 2000-07-04
KR100340290B1 (ko) 2002-06-15
US6913743B2 (en) 2005-07-05
ES2198446T3 (es) 2004-02-01
ZA959707B (en) 1996-05-29
EP1181940B1 (de) 2004-12-22
US20030170179A1 (en) 2003-09-11
IL141384A (en) 2008-06-05

Similar Documents

Publication Publication Date Title
DE59510658D1 (de) Verfahren zur in-vivo-diagnostik mittels nir-strahlung unter verwendung von cyaninfarbstoffen
EP2393420A1 (de) Ladungsausgeglichene kontrastmittel
CN103038289A (zh) 作为造影剂的萘并花菁
RU2011113876A (ru) Визуализирующие агенты для фиброзных заболеваний
CA2630046A1 (en) Fluorescent membrane intercalating probes and methods for their use
DE3405859A1 (de) Sulfongruppenhaltige azoverbindungen
EP0019842B1 (de) 1:2 Chromkomplexfarbstoff der Monoazoreihe und dessen Verwendung beim Färben von Polyamid
DE1012010B (de) Verfahren zur Herstellung von kobalthaltigen Monoazofarbstoffen
DE1276844B (de) Verfahren zur Herstellung von wasserloeslichen Azofarbstoffen
DE894294C (de) Verfahren zur Herstellung von Monoazofarbstoffen der Pyrazolonreihe
DE1444703C3 (de) Phthalocyaninreaktivfarbstoffe und Verfahren zu ihrer Herstellung
DE636356C (de) Verfahren zur Herstellung von chromhaltigen Azofarbstoffen
DE2142727C3 (de) Wasserlösliche Monoazopyrazolon-Farbstoffe Verfahren zu ihrer Herstellung und ihre Verwendung
DE600544C (de) Verfahren zur Herstellung von Monoazofarbstoffen
DE136616C (de)
DE831716C (de) Verfahren zur Herstellung von wasserloeslichen Monoazofarbstoffen
DE2159802A1 (de) Monoazofarbstoffe
Schneckenburger et al. Intracellular and in vivo Composition of Hematoporphyrin Derivative by Various Fluorescent Components
DE4203279A1 (de) Reaktivfarbstoffe, deren herstellung und verwendung
DE1444703B2 (de) Phthalocyaninreaktivfarbstoffe und verfahren zu ihrer herstellung

Legal Events

Date Code Title Description
8364 No opposition during term of opposition