DE59511027D1 - 3'-Modifizierte Oligonucleotid-Derivate - Google Patents

3'-Modifizierte Oligonucleotid-Derivate

Info

Publication number
DE59511027D1
DE59511027D1 DE59511027T DE59511027T DE59511027D1 DE 59511027 D1 DE59511027 D1 DE 59511027D1 DE 59511027 T DE59511027 T DE 59511027T DE 59511027 T DE59511027 T DE 59511027T DE 59511027 D1 DE59511027 D1 DE 59511027D1
Authority
DE
Germany
Prior art keywords
alkyl
aryl
alkoxy
formula
nhr
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE59511027T
Other languages
English (en)
Inventor
Dr Peyman
Dr Uhlmann
Carolin Carolus
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanofi Aventis Deutschland GmbH
Original Assignee
Sanofi Aventis Deutschland GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE4420737A external-priority patent/DE4420737A1/de
Priority claimed from DE4424263A external-priority patent/DE4424263A1/de
Application filed by Sanofi Aventis Deutschland GmbH filed Critical Sanofi Aventis Deutschland GmbH
Priority to DE59511027T priority Critical patent/DE59511027D1/de
Application granted granted Critical
Publication of DE59511027D1 publication Critical patent/DE59511027D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/34—Esters of acyclic saturated polycarboxylic acids having an esterified carboxyl group bound to an acyclic carbon atom
    • C07C69/40—Succinic acid esters
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
DE59511027T 1994-06-15 1995-06-09 3'-Modifizierte Oligonucleotid-Derivate Expired - Lifetime DE59511027D1 (de)

Priority Applications (1)

Application Number Priority Date Filing Date Title
DE59511027T DE59511027D1 (de) 1994-06-15 1995-06-09 3'-Modifizierte Oligonucleotid-Derivate

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE4420737A DE4420737A1 (de) 1994-06-15 1994-06-15 Neue 3'-Modifizierte Oligonucleotid-Derivate
DE4424263A DE4424263A1 (de) 1994-07-09 1994-07-09 Neue 3'-Modifizierte Oligonucleotid-Derivate
DE59511027T DE59511027D1 (de) 1994-06-15 1995-06-09 3'-Modifizierte Oligonucleotid-Derivate

Publications (1)

Publication Number Publication Date
DE59511027D1 true DE59511027D1 (de) 2006-01-19

Family

ID=25937419

Family Applications (1)

Application Number Title Priority Date Filing Date
DE59511027T Expired - Lifetime DE59511027D1 (de) 1994-06-15 1995-06-09 3'-Modifizierte Oligonucleotid-Derivate

Country Status (9)

Country Link
US (1) US5696248A (de)
EP (1) EP0688784B1 (de)
JP (1) JP4398517B2 (de)
AT (1) ATE312840T1 (de)
AU (1) AU701333B2 (de)
CA (2) CA2151801C (de)
DE (1) DE59511027D1 (de)
DK (1) DK0688784T3 (de)
ES (1) ES2253740T3 (de)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6291438B1 (en) 1993-02-24 2001-09-18 Jui H. Wang Antiviral anticancer poly-substituted phenyl derivatized oligoribonucleotides and methods for their use
US6207646B1 (en) 1994-07-15 2001-03-27 University Of Iowa Research Foundation Immunostimulatory nucleic acid molecules
US5855911A (en) * 1995-08-29 1999-01-05 Board Of Regents, The University Of Texas System Liposomal phosphodiester, phosphorothioate, and P-ethoxy oligonucleotides
US7309692B1 (en) * 1996-07-08 2007-12-18 Board Of Regents, The University Of Texas System Inhibition of chronic myelogenous leukemic cell growth by liposomal-antisense oligodeoxy-nucleotides targeting to GRB2 or CRK1
US6977244B2 (en) * 1996-10-04 2005-12-20 Board Of Regents, The University Of Texas Systems Inhibition of Bcl-2 protein expression by liposomal antisense oligodeoxynucleotides
US6723706B2 (en) 1997-05-05 2004-04-20 Aventis Pharma Deutschland Gmbh Modified antisense nucleotides complementary to a section of the human Ha-ras gene
US7285288B1 (en) 1997-10-03 2007-10-23 Board Of Regents, The University Of Texas System Inhibition of Bcl-2 protein expression by liposomal antisense oligodeoxynucleotides
US7704962B1 (en) 1997-10-03 2010-04-27 Board Of Regents, The University Of Texas System Small oligonucleotides with anti-tumor activity
US20040186071A1 (en) 1998-04-13 2004-09-23 Bennett C. Frank Antisense modulation of CD40 expression
US5968826A (en) * 1998-10-05 1999-10-19 Isis Pharmaceuticals Inc. Antisense inhibition of integrin α4 expression
WO2000040592A1 (en) * 1998-12-30 2000-07-13 Oligos Etc. Inc. Acid stable backbone modified end-blocked nucleic acids and therapeutic uses thereof
DE10019252A1 (de) * 2000-04-18 2001-10-31 Klaus Karl Degitz Polydesoxyribonukleotide zur Hemmung der ICAM-1-Genexpression
CA2471967A1 (en) * 2002-01-03 2003-07-31 Board Of Regents, The University Of Texas System Wt1 antisense oligos for the inhibition of breast cancer
GB0209539D0 (en) * 2002-04-26 2002-06-05 Avecia Ltd Monomer Polymer and process
AR040996A1 (es) 2002-08-19 2005-04-27 Coley Pharm Group Inc Acidos nucleicos inmunoestimuladores
AU2003300919A1 (en) 2002-12-11 2004-06-30 Coley Pharmaceutical Gmbh 5' cpg nucleic acids and methods of use
CA2520538C (en) 2003-03-31 2014-04-29 F. Hoffmann-La Roche Ag Compositions and methods for detecting certain flaviviruses, including members of the japanese encephalitis virus serogroup
CA2540949A1 (en) 2003-10-30 2005-05-12 Coley Pharmaceutical Gmbh C-class oligonucleotide analogs with enhanced immunostimulatory potency
JP2008516991A (ja) 2004-10-20 2008-05-22 アンチセンス セラピューティクス リミテッド インテグリンα４発現のアンチセンス調節
MY159370A (en) 2004-10-20 2016-12-30 Coley Pharm Group Inc Semi-soft-class immunostimulatory oligonucleotides
MX2009003398A (es) 2006-09-27 2009-08-12 Coley Pharm Gmbh Analogos de oligonucleotidos cpg que contienen analogos t hidrofobos con actividad inmunoestimuladora mejorada.
EP2222851B1 (de) 2007-11-20 2017-06-28 Ionis Pharmaceuticals, Inc. Modulation der cd40-expression
US8889890B2 (en) 2009-09-11 2014-11-18 Segetis, Inc. Ketal esters of oxocarboxylic acids and process of making
WO2013120003A1 (en) 2012-02-08 2013-08-15 Isis Pharmaceuticals, Inc. Modulation of rna by repeat targeting

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR930016437A (ko) * 1992-01-22 1993-08-26 귀틀라인, 슈미트 올리고뉴클레오티드 유사체, 이의 제조방법 및 용도
US5646261A (en) * 1992-01-22 1997-07-08 Hoechst Aktiengesellschaft 3'-derivatized oligonucleotide analogs with non-nucleotidic groupings, their preparation and use

Also Published As

Publication number Publication date
DK0688784T3 (da) 2006-04-18
AU701333B2 (en) 1999-01-28
CA2628883C (en) 2011-02-15
EP0688784A2 (de) 1995-12-27
AU2165995A (en) 1995-12-21
US5696248A (en) 1997-12-09
CA2628883A1 (en) 1995-12-16
JPH0827178A (ja) 1996-01-30
CA2151801A1 (en) 1995-12-16
EP0688784B1 (de) 2005-12-14
ATE312840T1 (de) 2005-12-15
ES2253740T3 (es) 2006-06-01
CA2151801C (en) 2008-08-19
JP4398517B2 (ja) 2010-01-13
EP0688784A3 (de) 1997-01-22

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