DE59606057D1 - Verfahren zur herstellung von dihydroxypyrimidin-derivaten - Google Patents

Verfahren zur herstellung von dihydroxypyrimidin-derivaten

Info

Publication number
DE59606057D1
DE59606057D1 DE59606057T DE59606057T DE59606057D1 DE 59606057 D1 DE59606057 D1 DE 59606057D1 DE 59606057 T DE59606057 T DE 59606057T DE 59606057 T DE59606057 T DE 59606057T DE 59606057 D1 DE59606057 D1 DE 59606057D1
Authority
DE
Germany
Prior art keywords
producing
dihydroxypyrimidine
derivatives
dihydroxypyrimidine derivatives
general formula
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE59606057T
Other languages
English (en)
Inventor
Beat Schmidt
Andreas Kiener
John Mcgarrity
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Lonza AG
Original Assignee
Lonza AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lonza AG filed Critical Lonza AG
Application granted granted Critical
Publication of DE59606057D1 publication Critical patent/DE59606057D1/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/52—Two oxygen atoms
    • C07D239/54—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/02—Amides, e.g. chloramphenicol or polyamides; Imides or polyimides; Urethanes, i.e. compounds comprising N-C=O structural element or polyurethanes
DE59606057T 1995-08-31 1996-08-30 Verfahren zur herstellung von dihydroxypyrimidin-derivaten Expired - Fee Related DE59606057D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH247495 1995-08-31
PCT/EP1996/003826 WO1997008152A1 (de) 1995-08-31 1996-08-30 Verfahren zur herstellung von dihydroxypyrimidin-derivaten

Publications (1)

Publication Number Publication Date
DE59606057D1 true DE59606057D1 (de) 2000-11-30

Family

ID=4234620

Family Applications (1)

Application Number Title Priority Date Filing Date
DE59606057T Expired - Fee Related DE59606057D1 (de) 1995-08-31 1996-08-30 Verfahren zur herstellung von dihydroxypyrimidin-derivaten

Country Status (11)

Country Link
US (1) US6248571B1 (de)
EP (1) EP0852580B1 (de)
JP (1) JP2000507911A (de)
AT (1) ATE197150T1 (de)
AU (1) AU6985796A (de)
CA (1) CA2227949A1 (de)
DE (1) DE59606057D1 (de)
DK (1) DK0852580T3 (de)
ES (1) ES2152563T3 (de)
PT (1) PT852580E (de)
WO (1) WO1997008152A1 (de)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10140269A1 (de) 2001-08-16 2003-02-27 Degussa Verfahren zur Herstellung von 4,6-Dihydroxypyrimidin
CN1685055A (zh) 2001-10-31 2005-10-19 爱尔康公司 骨形态发生蛋白(bmp)、bmp受体和bmp结合蛋白及它们在诊断和治疗青光眼中的用途
US20030143601A1 (en) * 2001-11-16 2003-07-31 Hansen Thomas R. Methods and compositions for the detection of bovine pregnancy which utilize members of the 1-8 family of interferon inducible genes
SG182004A1 (en) 2003-01-14 2012-07-30 Arena Pharm Inc 1,2,3-trisubstituted aryl and heteroaryl derivatives as modulators of metabolism and the prophylaxis and treatment of disorders related thereto such as diabetes and hyperglycemia
AR045047A1 (es) 2003-07-11 2005-10-12 Arena Pharm Inc Derivados arilo y heteroarilo trisustituidos como moduladores del metabolismo y de la profilaxis y tratamiento de desordenes relacionados con los mismos
US7854756B2 (en) 2004-01-22 2010-12-21 Boston Scientific Scimed, Inc. Medical devices
SG188548A1 (en) 2010-09-22 2013-04-30 Arena Pharm Inc Modulators of the gpr119 receptor and the treatment of disorders related thereto
CZ305457B6 (cs) 2011-02-28 2015-09-30 Ústav organické chemie a biochemie, Akademie věd ČR v. v. i. Pyrimidinové sloučeniny inhibující tvorbu oxidu dusnatého a prostaglandinu E2, způsob výroby a použití
CN102442954B (zh) * 2011-09-06 2014-01-08 淄博万昌科技股份有限公司 利用丙烯腈副产氢氰酸制备4，6-二羟基嘧啶的方法
MX2017008925A (es) 2015-01-06 2017-10-11 Arena Pharm Inc Metodos de condiciones de tratamiento relacionadas con el receptor s1p1.
KR102603199B1 (ko) 2015-06-22 2023-11-16 아레나 파마슈티칼스, 인크. Ｓ1ｐ1 수용체-관련 장애에서의 사용을 위한 (ｒ)-2-(7-(4-시클로펜틸-3-(트리플루오로메틸)벤질옥시)-1,2,3,4-테트라히드로시클로-펜타[ｂ]인돌-3-일)아세트산 (화합물 1)의 결정성 ｌ-아르기닌 염
WO2020136130A1 (de) * 2018-12-28 2020-07-02 Saltigo Gmbh Verbessertes verfahren zur herstellung von 4,6-dihydroxypyrimidin

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1424940A (fr) * 1964-02-21 1966-01-14 Kyowa Hakko Kogyo Kk Procédé de production de la 4, 6-dihydroxypyrimidine
US3306900A (en) * 1964-02-21 1967-02-28 Kyowa Hakko Kogyo Kk Method for producing 4,6-dihydroxy-pyrimidine
JPH06256278A (ja) * 1993-03-03 1994-09-13 Nissan Chem Ind Ltd 光学活性α−カルバモイルアルカン酸誘導体およびその製法
JPH0799983A (ja) * 1993-10-05 1995-04-18 Nippon Kayaku Co Ltd 微生物によるｐ−ニトロベンジルアルコールマロン酸モノエステルの製造方法

Also Published As

Publication number Publication date
ATE197150T1 (de) 2000-11-15
EP0852580B1 (de) 2000-10-25
ES2152563T3 (es) 2001-02-01
CA2227949A1 (en) 1997-03-06
EP0852580A1 (de) 1998-07-15
WO1997008152A1 (de) 1997-03-06
PT852580E (pt) 2001-02-28
US6248571B1 (en) 2001-06-19
DK0852580T3 (da) 2000-11-20
JP2000507911A (ja) 2000-06-27
AU6985796A (en) 1997-03-19

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee