DE60011396D1 - Verfahren zur herstellung von iopamidol - Google Patents

Verfahren zur herstellung von iopamidol

Info

Publication number
DE60011396D1
DE60011396D1 DE60011396T DE60011396T DE60011396D1 DE 60011396 D1 DE60011396 D1 DE 60011396D1 DE 60011396 T DE60011396 T DE 60011396T DE 60011396 T DE60011396 T DE 60011396T DE 60011396 D1 DE60011396 D1 DE 60011396D1
Authority
DE
Germany
Prior art keywords
iopamidol
producing
producing iopamidol
contrast agents
ionic contrast
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60011396T
Other languages
English (en)
Other versions
DE60011396T2 (de
Inventor
Richard A Lorenzini
Ashok V Bhatia
Steven A Chamberlin
Keith A Drengler
John J Hufnagel
Xiu C Wang
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bracco Imaging SpA
Original Assignee
Bracco Imaging SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bracco Imaging SpA filed Critical Bracco Imaging SpA
Application granted granted Critical
Publication of DE60011396D1 publication Critical patent/DE60011396D1/de
Publication of DE60011396T2 publication Critical patent/DE60011396T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/12—Preparation of carboxylic acid amides by reactions not involving the formation of carboxamide groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/28—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton
    • C07C237/46—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton having carbon atoms of carboxamide groups, amino groups and at least three atoms of bromine or iodine, bound to carbon atoms of the same non-condensed six-membered aromatic ring
DE60011396T 1999-02-26 2000-02-23 Verfahren zur herstellung von iopamidol Expired - Lifetime DE60011396T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US257690 1981-04-27
US09/257,690 US6803485B2 (en) 1999-02-26 1999-02-26 Process for the preparation of iopamidol
PCT/US2000/004511 WO2000050385A1 (en) 1999-02-26 2000-02-23 Process for the preparation of iopamidol

Publications (2)

Publication Number Publication Date
DE60011396D1 true DE60011396D1 (de) 2004-07-15
DE60011396T2 DE60011396T2 (de) 2005-06-23

Family

ID=22977346

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60011396T Expired - Lifetime DE60011396T2 (de) 1999-02-26 2000-02-23 Verfahren zur herstellung von iopamidol

Country Status (10)

Country Link
US (4) US6803485B2 (de)
EP (1) EP1154986B1 (de)
JP (1) JP4540233B2 (de)
AT (1) ATE268749T1 (de)
CA (1) CA2364819C (de)
DE (1) DE60011396T2 (de)
DK (1) DK1154986T3 (de)
ES (1) ES2220429T3 (de)
PT (1) PT1154986E (de)
WO (1) WO2000050385A1 (de)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6803485B2 (en) * 1999-02-26 2004-10-12 Bracco Imaging S.P.A. Process for the preparation of iopamidol
IT1319671B1 (it) * 2000-12-01 2003-10-23 Bracco Spa Processo per la preparazione di (s)-n,n'-bis(2-idrossi-1-(idrossimetil)etil)-5-((2-idrossi-1-ossopropil)ammino)
GB0123013D0 (en) * 2001-09-25 2001-11-14 Upperton Ltd Improvements relating to imaging contrast agents
US20040054162A1 (en) * 2001-10-30 2004-03-18 Hanna Michelle M. Molecular detection systems utilizing reiterative oligonucleotide synthesis
NO20055643D0 (no) * 2005-11-29 2005-11-29 Amersham Health As Preparation of lodixanol
US8907193B2 (en) * 2007-02-20 2014-12-09 Ubisoft Entertainment Instrument game system and method
EP2240432B1 (de) * 2008-01-14 2012-07-04 Mallinckrodt LLC Verfahren zur herstellung von iosimenol
US20110021824A1 (en) * 2009-07-21 2011-01-27 Ge Healthcare As Adsorptive purification method for iodixanol
WO2012136813A2 (en) 2011-04-07 2012-10-11 Universitetet I Oslo Agents for medical radar diagnosis
PT105770B (pt) * 2011-06-24 2013-07-08 Hovione Farmaciencia S A Novo intermediário e seu uso na preparação de agente de contrate triiodado
CN103382160B (zh) * 2012-05-02 2017-10-27 上海海神化学生物科技有限公司 碘帕醇的合成及其合成中间体的制备
US9950991B2 (en) 2013-11-05 2018-04-24 Bracco Imaging S.P.A. Process for the preparation of iopamidol
CN105017062B (zh) * 2014-04-18 2018-11-20 沈阳中海生物技术开发有限公司 制备碘普罗胺的新方法
CN104098484A (zh) * 2014-07-21 2014-10-15 杭州杜易科技有限公司 一种碘帕醇的制备方法
CN106831480B (zh) * 2015-12-07 2019-01-15 北京大学 基于碘帕醇脂质衍生物的造影剂及其制备方法与用途
US11517574B2 (en) 2017-11-16 2022-12-06 Persica Pharmaceuticals Ltd. Linezolid formulations
KR20220139775A (ko) 2021-04-08 2022-10-17 한양대학교 에리카산학협력단 이오파미돌의 제조방법
CN115010617A (zh) * 2022-07-11 2022-09-06 安徽普利药业有限公司 一种碘帕醇的制备方法

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH608189A5 (de) * 1974-12-13 1978-12-29 Savac Ag
IT1193211B (it) 1979-08-09 1988-06-15 Bracco Ind Chimica Spa Derivati dell'acido 2,4,6-triiodo-isoftalico,metodo per la loro preparazione e mezzi di contrasto che li contengono
US4396598A (en) * 1982-01-11 1983-08-02 Mallinckrodt, Inc. Triiodoisophthalamide X-ray contrast agent
FR2541676A1 (fr) 1983-02-25 1984-08-31 Guerbet Sa Composes non-ioniques a structures benzenique iodee ou bromee et produits opacifiants en contenant
US4997983A (en) * 1990-01-31 1991-03-05 Mallinckrodt, Inc. Process for production of ioversol
US5204005A (en) 1990-02-26 1993-04-20 Mallinckrodt, Inc. Reversed phase chromatographic process
US5527926A (en) 1990-11-26 1996-06-18 Bracco International B.V. Methods and compositions for using non-ionic contrast agents to reduce the risk of clot formation in diagnostic procedures
IT1248741B (it) 1991-02-26 1995-01-26 Bracco Spa Processo di concentrazione e di purificazione di composti organici
US5256393A (en) 1991-04-16 1993-10-26 Mallinckrodt Medical, Inc. Use of azeotropic distillation in process to dry 5-amino-N,N'bis (2,3-dihydroxypropyl)-2,4,6-triiodoisphthalamide
CA2068089C (en) 1991-05-31 2003-09-16 Ramachandran S. Ranganathan Method and compositions for using non-ionic contrast agents to reduce the risk of clot formulation in diagnostic procedures
US5177261A (en) 1991-07-22 1993-01-05 Mallinckrodt Medical, Inc. Synthesis of ioversol using chloroacetyl chloride
IT1256162B (it) 1992-10-27 1995-11-29 Zambon Spa Processo per la preparazione di un intermedio della sintesi organica
IT1256163B (it) 1992-10-27 1995-11-29 Zambon Spa Processo per la preparazione di un intermedio della sintesi organica
US5396003A (en) * 1993-05-27 1995-03-07 Mallinckrodt Medical Pmc Recovery and purification of 1,1,2-trichloroethane for reuse in the production of ioversol
IL110391A (en) 1993-07-30 1998-12-06 Zambon Spa Process for the formation of infamidol
IT1274027B (it) 1994-03-03 1997-07-14 Zambon Spa Processo per la preparazione e purificazione di mezzi di contrasto iodurati
US5371278A (en) 1994-03-25 1994-12-06 Mallinckrodt Medical Pmc Synthesis of ioversol using a minimal excess of acetoxyacetylchloride
IT1286522B1 (it) * 1996-12-04 1998-07-15 Dibra Spa Processo per la preparazione di derivati dell'acido 5-ammino-2,4,6- triiodo-1,3-benzenedicarbossilico
US6803485B2 (en) * 1999-02-26 2004-10-12 Bracco Imaging S.P.A. Process for the preparation of iopamidol

Also Published As

Publication number Publication date
DK1154986T3 (da) 2004-10-18
DE60011396T2 (de) 2005-06-23
EP1154986B1 (de) 2004-06-09
CA2364819A1 (en) 2000-08-31
US20050192465A1 (en) 2005-09-01
JP2002537371A (ja) 2002-11-05
WO2000050385A1 (en) 2000-08-31
PT1154986E (pt) 2004-09-30
US6875887B2 (en) 2005-04-05
ES2220429T3 (es) 2004-12-16
US20040236150A1 (en) 2004-11-25
CA2364819C (en) 2008-12-02
JP4540233B2 (ja) 2010-09-08
US7282607B2 (en) 2007-10-16
EP1154986A1 (de) 2001-11-21
US20010056206A1 (en) 2001-12-27
US7115778B2 (en) 2006-10-03
US6803485B2 (en) 2004-10-12
ATE268749T1 (de) 2004-06-15
US20070078281A1 (en) 2007-04-05

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Legal Events

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