DE60026718D1 - Einstufiges verfahren zur herstellung von 7,16-deoxy-2-aza-10-o-cladinosil-12-o-desosaminil-4,5-dihydroxi-6-ethyl-3,5,9,11,13,15-hexamethylbicycle(11.2.11)hexadeca-1(2)-en-8-ona undeine neue form von 9-desoxo-9a-methyl-9a-aza-9a-homoerythromycin a - Google Patents

Einstufiges verfahren zur herstellung von 7,16-deoxy-2-aza-10-o-cladinosil-12-o-desosaminil-4,5-dihydroxi-6-ethyl-3,5,9,11,13,15-hexamethylbicycle(11.2.11)hexadeca-1(2)-en-8-ona undeine neue form von 9-desoxo-9a-methyl-9a-aza-9a-homoerythromycin a

Info

Publication number
DE60026718D1
DE60026718D1 DE60026718T DE60026718T DE60026718D1 DE 60026718 D1 DE60026718 D1 DE 60026718D1 DE 60026718 T DE60026718 T DE 60026718T DE 60026718 T DE60026718 T DE 60026718T DE 60026718 D1 DE60026718 D1 DE 60026718D1
Authority
DE
Germany
Prior art keywords
aza
hexamethylbicycle
homoerythromycin
hexadeca
ona
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60026718T
Other languages
English (en)
Other versions
DE60026718T2 (de
Inventor
La Torre Garcia Juan Antoni De
Andrade Fidencio Franco
Ochoa Francisco Lara
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
INST DE INVESTIGACION EN QUIMI
Laboratorios Silanes SA de CV
Original Assignee
INST DE INVESTIGACION EN QUIMI
Laboratorios Silanes SA de CV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by INST DE INVESTIGACION EN QUIMI, Laboratorios Silanes SA de CV filed Critical INST DE INVESTIGACION EN QUIMI
Application granted granted Critical
Publication of DE60026718D1 publication Critical patent/DE60026718D1/de
Publication of DE60026718T2 publication Critical patent/DE60026718T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D267/00—Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
DE60026718T 2000-07-25 2000-07-25 Einstufiges verfahren zur herstellung von 7,16-deoxy-2-aza-10-o-cladinosil-12-o-desosaminil-4,5-dihydroxi-6-ethyl-3,5,9,11,13,15-hexamethylbicycle(11.2.11)hexadeca-1(2)-en-8-ona undeine neue form von 9-desoxo-9a-methyl-9a-aza-9a-homoerythromycin a Expired - Lifetime DE60026718T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/MX2000/000030 WO2002010144A1 (es) 2000-07-25 2000-07-25 PROCESO PARA LA PREPARACION EN UN SOLO PASO DE 7,16-DIOXA-2-AZA-10-O-CLADINOSIL-12-O-DESOSAMINIL-4,5-DIHIDROXI-6-ETIL-3,5,9,11,13,15-HEXAMETILBICICLO[11.2.1]HEXADECA-1(2)-EN-8-ONA Y OBTENCION DE UNA FORMA NUEVA DE 9-DESOXO-9a-AZA-9a-METIL-9a-HOMOERITROMICINA A

Publications (2)

Publication Number Publication Date
DE60026718D1 true DE60026718D1 (de) 2006-05-11
DE60026718T2 DE60026718T2 (de) 2006-11-16

Family

ID=19741683

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60026718T Expired - Lifetime DE60026718T2 (de) 2000-07-25 2000-07-25 Einstufiges verfahren zur herstellung von 7,16-deoxy-2-aza-10-o-cladinosil-12-o-desosaminil-4,5-dihydroxi-6-ethyl-3,5,9,11,13,15-hexamethylbicycle(11.2.11)hexadeca-1(2)-en-8-ona undeine neue form von 9-desoxo-9a-methyl-9a-aza-9a-homoerythromycin a

Country Status (8)

Country Link
US (1) US6528492B1 (de)
EP (1) EP1304326B1 (de)
AT (1) ATE320441T1 (de)
AU (1) AU2000270425A1 (de)
CA (1) CA2417353C (de)
DE (1) DE60026718T2 (de)
ES (1) ES2260047T3 (de)
WO (1) WO2002010144A1 (de)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HRP20020231A2 (en) * 2002-03-18 2003-12-31 Pliva D D ISOSTRUCTURAL PSEUDOPOLYMORPHS OF 9-DEOXO-9a-AZA-9a-METHYL-9a-HOMOERYTHROMYCIN A
US6861413B2 (en) 2001-05-22 2005-03-01 Pfizer Inc. Stable non-dihydrate azithromycin oral suspensions
AU2002256846B2 (en) * 2001-05-22 2007-04-05 Pfizer Products Inc. Crystal Forms of Azithromycin
HRP20020614A2 (en) * 2002-07-22 2004-06-30 PLIVA-ISTRAŽIVAČKI INSTITUT d.o.o. Rhombic pseudopolymorph of 9-deoxo-9a-aza-9a-methyl-9a-homoerythromycin a
US7468428B2 (en) * 2004-03-17 2008-12-23 App Pharmaceuticals, Llc Lyophilized azithromycin formulation
US20060116336A1 (en) * 2004-03-17 2006-06-01 American Pharmaceutical Partners, Inc. Lyophilized azithromycin formulation
US20090093420A1 (en) * 2006-01-12 2009-04-09 Wockhardt Limited Processes for the preparation of azithromycin
EP2405909A1 (de) 2009-03-13 2012-01-18 Da Volterra Zusammensetzungen und verfahren zur eliminierung von gram-negativen bakterien
CN103087125B (zh) * 2013-02-06 2015-12-02 浙江国邦药业有限公司 制备阿奇霉素一锅煮的工艺方法

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1100504A (en) 1967-08-16 1968-01-24 Pliva Pharm & Chem Works Erythromycin oxime and 9-amino-3-o-cladinosyl-5-o-desosaminyl-6,11,12-trihydroxy-2,4,6,8,10,12-hexamethylpentadecane-13-olide
SI7910768A8 (en) 1979-04-02 1996-06-30 Pliva Pharm & Chem Works Process for pripering 11-aza-4-0-cladinosyl-6-0-desosaminyl-15-ethyl- 7,13,14-trihydroxy-3,5,7,9,12,14-hexamethyl- oxacyclopentadecane-2-one and their derivatives
YU43006B (en) 1981-03-06 1989-02-28 Pliva Pharm & Chem Works Process for preparing n-methyl-11-aza-10-deoxo-10-dihydro erythromycin and derivatives thereof
US4474768A (en) 1982-07-19 1984-10-02 Pfizer Inc. N-Methyl 11-aza-10-deoxo-10-dihydro-erytromycin A, intermediates therefor
RU2066324C1 (ru) 1987-07-09 1996-09-10 Пфайзер Инк. Кристаллический дигидрат азитромицина и способ его получения
WO1989002271A1 (en) 1987-09-10 1989-03-23 Pfizer Azithromycin and derivatives as antiprotozoal agents
DE69403963T2 (de) 1993-05-19 1997-11-20 Pfizer Zwischenprodukt für azithromycin
US5605889A (en) * 1994-04-29 1997-02-25 Pfizer Inc. Method of administering azithromycin
ES2122905B1 (es) * 1996-07-11 1999-11-16 Astur Pharma Sa Sintesis de 11,12-hidrogenoortoborato de 9-desoxo-9a-aza-11,12-desoxi-9a-metil-9a-homoeritromicina a. un procedimiento para la preparacion de 9-desoxo-9a-aza-9a-metil-9a-homoeritromicina a dihidrato (azitromicina dihidrato).
PT102006B (pt) 1997-05-19 2000-06-30 Hovione Sociedade Quimica S A Novo processo de preparacao de azitromicina
TW546302B (en) 1998-05-08 2003-08-11 Biochemie Sa Improvements in macrolide production
CA2245398C (en) 1998-08-21 2002-01-29 Apotex Inc. Azithromycin monohydrate isopropanol clathrate and methods for the manufacture thereof
GB9824580D0 (en) * 1998-11-10 1999-01-06 Biochemie Sa Organic compounds
EP1712556B1 (de) 1999-06-29 2010-06-02 Sandoz AG Azithromycinmonohydrat
AU2001214115A1 (en) 2000-08-01 2002-02-13 Habil F. Khorakiwala Process for the preparation of anhydrous azithromycin
CA2419873A1 (en) 2000-08-23 2002-02-28 Wockhardt Limited Process for preparation of anhydrous azithromycin

Also Published As

Publication number Publication date
EP1304326A1 (de) 2003-04-23
CA2417353C (en) 2009-09-01
AU2000270425A1 (en) 2002-02-13
WO2002010144A1 (es) 2002-02-07
DE60026718T2 (de) 2006-11-16
ATE320441T1 (de) 2006-04-15
CA2417353A1 (en) 2003-01-27
ES2260047T3 (es) 2006-11-01
US6528492B1 (en) 2003-03-04
EP1304326A4 (de) 2004-06-16
EP1304326B1 (de) 2006-03-15

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