DE60031114D1 - Flüssige gelformulierung zum detektieren von milchkanälen in der brust vor einer chirurgischen ablation des brustgewebes - Google Patents

Flüssige gelformulierung zum detektieren von milchkanälen in der brust vor einer chirurgischen ablation des brustgewebes

Info

Publication number
DE60031114D1
DE60031114D1 DE60031114T DE60031114T DE60031114D1 DE 60031114 D1 DE60031114 D1 DE 60031114D1 DE 60031114 T DE60031114 T DE 60031114T DE 60031114 T DE60031114 T DE 60031114T DE 60031114 D1 DE60031114 D1 DE 60031114D1
Authority
DE
Germany
Prior art keywords
breast tissue
breast
gel formulation
liquid gel
before surgical
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60031114T
Other languages
English (en)
Other versions
DE60031114T2 (de
Inventor
Annette Bianchi
Julian Nikolchev
David Hung
Eyal Ron
Linda Gont
Susan Love
Tina Patel
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Cytyc Corp
Original Assignee
Cytyc Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cytyc Corp filed Critical Cytyc Corp
Publication of DE60031114D1 publication Critical patent/DE60031114D1/de
Application granted granted Critical
Publication of DE60031114T2 publication Critical patent/DE60031114T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0041—Mammary glands, e.g. breasts, udder; Intramammary administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/54—Chiropodists' instruments, e.g. pedicure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/74—Synthetic polymeric materials
    • A61K31/765—Polymers containing oxygen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
    • A61K41/0023—Agression treatment or altering
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
    • A61K41/0042—Photocleavage of drugs in vivo, e.g. cleavage of photolabile linkers in vivo by UV radiation for releasing the pharmacologically-active agent from the administered agent; photothrombosis or photoocclusion
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0013—Luminescence
    • A61K49/0017—Fluorescence in vivo
    • A61K49/0019—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules
    • A61K49/0021—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules the fluorescent group being a small organic molecule
    • A61K49/0041—Xanthene dyes, used in vivo, e.g. administered to a mice, e.g. rhodamines, rose Bengal
    • A61K49/0043—Fluorescein, used in vivo
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/006—Biological staining of tissues in vivo, e.g. methylene blue or toluidine blue O administered in the buccal area to detect epithelial cancer cells, dyes used for delineating tissues during surgery
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0063—Preparation for luminescence or biological staining characterised by a special physical or galenical form, e.g. emulsions, microspheres
    • A61K49/0069—Preparation for luminescence or biological staining characterised by a special physical or galenical form, e.g. emulsions, microspheres the agent being in a particular physical galenical form
    • A61K49/0073—Preparation for luminescence or biological staining characterised by a special physical or galenical form, e.g. emulsions, microspheres the agent being in a particular physical galenical form semi-solid, gel, hydrogel, ointment
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/04—X-ray contrast preparations
    • A61K49/0433—X-ray contrast preparations containing an organic halogenated X-ray contrast-enhancing agent
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/32—Surgical cutting instruments
    • A61B2017/320004—Surgical cutting instruments abrasive
    • A61B2017/320008—Scrapers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
DE60031114T 1999-06-11 2000-06-09 Flüssige gelformulierung zum detektieren von milchkanälen in der brust vor einer chirurgischen ablation des brustgewebes Expired - Lifetime DE60031114T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US13869399P 1999-06-11 1999-06-11
US138693P 1999-06-11
PCT/US2000/015993 WO2000076555A1 (en) 1999-06-11 2000-06-09 Gel composition for filing a breast milk duct prior to surgical excision of the duct or other breast tissue

Publications (2)

Publication Number Publication Date
DE60031114D1 true DE60031114D1 (de) 2006-11-16
DE60031114T2 DE60031114T2 (de) 2007-05-03

Family

ID=22483196

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60031114T Expired - Lifetime DE60031114T2 (de) 1999-06-11 2000-06-09 Flüssige gelformulierung zum detektieren von milchkanälen in der brust vor einer chirurgischen ablation des brustgewebes

Country Status (9)

Country Link
US (5) US6589998B1 (de)
EP (1) EP1185309B1 (de)
AT (1) ATE341345T1 (de)
AU (1) AU769853B2 (de)
CA (1) CA2375576A1 (de)
DE (1) DE60031114T2 (de)
ES (1) ES2273702T3 (de)
IL (2) IL146801A0 (de)
WO (1) WO2000076555A1 (de)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030039959A1 (en) * 1998-10-02 2003-02-27 Susan Love Methods for identification, diagnosis, and treatment of breast cancer
DE60031114T2 (de) * 1999-06-11 2007-05-03 Cytyc Corp., Marlborough Flüssige gelformulierung zum detektieren von milchkanälen in der brust vor einer chirurgischen ablation des brustgewebes
WO2001093917A2 (en) * 2000-06-08 2001-12-13 Cytyc Health Corporation Preparation for breast duct fluid collection
US6743228B2 (en) 2001-09-12 2004-06-01 Manoa Medical, Inc. Devices and methods for tissue severing and removal
US6736781B2 (en) 2001-09-12 2004-05-18 Manoa Medical, Inc. Ultrasound imaging of breast tissue using ultrasound contrast agent
JP4578817B2 (ja) * 2004-02-06 2010-11-10 オリンパス株式会社 外科手術用病変部同定システム
US8835473B2 (en) * 2004-04-16 2014-09-16 Rutgers, The State University Of New Jersey Methods and compositions for treating cancer
US7907991B2 (en) * 2005-03-02 2011-03-15 C. R. Bard, Inc. System and method for marking body cavities
US20070191816A1 (en) * 2006-02-13 2007-08-16 Boston Scientific Scimed, Inc. Radio frequency induced drug elution
WO2009045543A1 (en) 2007-10-04 2009-04-09 The Regents Of The University Of California Treatment of conditions related to shock
US20100069781A1 (en) * 2008-04-15 2010-03-18 Johansen Jerald A Device and method for accessing and treating ducts of mammary glands
US20130158394A1 (en) * 2010-01-14 2013-06-20 The Regents Of The University Of California Devices, Systems and Methods to Detect and Reduce or Prevent Entry of Inflammatory Mediators into Milk Ducts
US20110301456A1 (en) * 2010-06-07 2011-12-08 Malignext Targeting Technologies, Inc. Tissue Marking for Lesion Removal
CA2813467A1 (en) 2010-10-02 2012-04-05 The Regents Of The University Of California Minimizing intestinal dysfunction
US10864271B2 (en) 2012-02-15 2020-12-15 Rutgers, The State University Of New Jersey Combination therapy using riluzole to enhance tumor sensitivity to ionizing radiation
WO2013188534A1 (en) * 2012-06-12 2013-12-19 Rutgers, The State University Of New Jersey Biomaterials for the prevention of post-operative adhesions

Family Cites Families (115)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US413228A (en) * 1889-10-22 Car-mover
US692777A (en) * 1901-06-20 1902-02-04 Daniel B Hall Vehicle-brake.
US2665597A (en) * 1951-03-08 1954-01-12 Boeing Co Expansible anchor
US2704076A (en) * 1953-02-20 1955-03-15 Herbert J Larson Dilators
US2827054A (en) * 1955-04-29 1958-03-18 Charles W Towne Teat dilator
US3342569A (en) * 1963-11-18 1967-09-19 Colgate Palmolive Co Alkanol gels
US3821956A (en) * 1973-08-14 1974-07-02 D Gordhamer Bovine teat dilator and medicament dispenser
SE7316352L (de) * 1973-12-04 1975-05-05
US3890311A (en) * 1974-03-18 1975-06-17 American Home Prod 7-(2-(1-(phenylsulfonyl)-2-pyrrolidinylthio)acetamino)cephalosporanic acids
US4188373A (en) * 1976-02-26 1980-02-12 Cooper Laboratories, Inc. Clear, water-miscible, liquid pharmaceutical vehicles and compositions which gel at body temperature for drug delivery to mucous membranes
US4431628A (en) * 1978-04-07 1984-02-14 Colgate-Palmolive Company Natural dye indicator for dental plaque
US4281658A (en) * 1979-07-09 1981-08-04 Child Laboratories, Inc. Dilator
US4585437A (en) * 1983-03-17 1986-04-29 Simms Mark D Introducer for an umbilical artery catheter
US4772268A (en) * 1984-05-25 1988-09-20 Cook Incorporated Two lumen hemodialysis catheter
US4619913A (en) 1984-05-29 1986-10-28 Matrix Pharmaceuticals, Inc. Treatments employing drug-containing matrices for introduction into cellular lesion areas
USRE35748E (en) 1984-05-29 1998-03-17 Matrix Pharmaceutical, Inc. Treatments employing drug containing matrices for introduction into cellular lesion areas
US4680028A (en) * 1984-07-02 1987-07-14 Lact-Assist, Incorporated Flexible breast receptor for breast pump
US5776093A (en) 1985-07-05 1998-07-07 Immunomedics, Inc. Method for imaging and treating organs and tissues
JPS6221171A (ja) * 1985-07-20 1987-01-29 Sanyo Electric Co Ltd 電子写真装置
US4767417A (en) * 1986-02-18 1988-08-30 Boehringer Laboratories Drainage device for collecting liquids from a body cavity
US4847065A (en) * 1987-02-10 1989-07-11 Akimova Alla Y Composition for occlusion of ducts and cavities of human body
CA1330285C (en) * 1987-12-22 1994-06-21 Geoffrey S. Martin Triple lumen catheter
US5681543A (en) * 1988-02-29 1997-10-28 Shering Aktiengesellschaft Polymer-bonded complexing agents and pharmaceutical agents containing them for MRI
US4957484A (en) * 1988-07-26 1990-09-18 Automedix Sciences, Inc. Lymph access catheters and methods of administration
US4938763B1 (en) 1988-10-03 1995-07-04 Atrix Lab Inc Biodegradable in-situ forming implants and method of producing the same
US5475052A (en) 1988-11-21 1995-12-12 Collagen Corporation Collagen-synthetic polymer matrices prepared using a multiple step reaction
EP0417821A1 (de) * 1989-09-13 1991-03-20 Duphar International Research B.V Verfahren zur Stabilisierung von Kolostrum für immunochemische Untersuchung
US4934038A (en) * 1989-09-15 1990-06-19 Caterpillar Inc. Method and apparatus for tube expansion
US5252318A (en) * 1990-06-15 1993-10-12 Allergan, Inc. Reversible gelation compositions and methods of use
AT397911B (de) * 1990-07-04 1994-08-25 Avl Verbrennungskraft Messtech Zweilumige entnahmenadel für körperflüssigkeiten
US5626863A (en) 1992-02-28 1997-05-06 Board Of Regents, The University Of Texas System Photopolymerizable biodegradable hydrogels as tissue contacting materials and controlled-release carriers
US5662913A (en) * 1991-04-10 1997-09-02 Capelli; Christopher C. Antimicrobial compositions useful for medical applications
US5318780A (en) 1991-10-30 1994-06-07 Mediventures Inc. Medical uses of in situ formed gels
US5780444A (en) * 1991-12-13 1998-07-14 Trustees Of Princeton University Compositions and methods for cell transformation
US5261887A (en) * 1992-01-22 1993-11-16 Baxter International Inc. Easy-to-handle, self-guiding catheter stripper
EP0560014A1 (de) 1992-03-12 1993-09-15 Atrix Laboratories, Inc. Biologisch abbaubarer Wundverband in Form eines Sprühfilms und Verfahren zu seiner Herstellung
US5271413A (en) * 1992-07-22 1993-12-21 Dalamagas Photios P Method to sense the tissue for injection from a hypodermic needle
US5342384A (en) * 1992-08-13 1994-08-30 Brigham & Women's Hospital Surgical dilator
US5735792A (en) * 1992-11-25 1998-04-07 Clarus Medical Systems, Inc. Surgical instrument including viewing optics and an atraumatic probe
US5350358A (en) * 1992-12-22 1994-09-27 Med-Pro Design, Inc. Bent co-axial catheter
FR2701380B1 (fr) * 1993-02-10 1995-04-07 Commissariat Energie Atomique Dispositif de traitement de signaux biologiques prélevés par des électrodes sur la peau d'un patient.
KR0162025B1 (ko) * 1993-04-16 1998-12-01 마키다 기요아키 가역성 열겔화 수성의약조성물
US5709854A (en) 1993-04-30 1998-01-20 Massachusetts Institute Of Technology Tissue formation by injecting a cell-polymeric solution that gels in vivo
ATE230243T1 (de) 1993-07-12 2003-01-15 Univ California Verstärkungsvorrichtung für weiches gewebe
US5364344A (en) * 1993-10-22 1994-11-15 The Kendall Company Dual lumen catheter
US6500114B1 (en) * 1993-11-23 2002-12-31 Dofi Technologies, Inc. Method of extracting biopsy cells from the breast
US5502092A (en) 1994-02-18 1996-03-26 Minnesota Mining And Manufacturing Company Biocompatible porous matrix of bioabsorbable material
AU1999995A (en) 1994-04-08 1995-11-10 Atrix Laboratories, Inc. An adjunctive polymer system for use with medical device
BR9507313B8 (pt) 1994-04-08 2016-06-07 Atrix Lab Inc composição líquida de liberação adequada para a formação de um implante de liberação controlada, sistema polimérico, curativo fílmico microporoso biodegradável, e, precursor de um implante de liberação controlada para a implantação em um indivíduo
US5360604A (en) * 1994-04-14 1994-11-01 Sterling Winthrop Inc. X-ray contrast compositions containing an organic crystalline X-ray contrast agent in combination with pharmaceutically acceptable clays
US5662585A (en) * 1994-05-05 1997-09-02 Imagyn Medical, Inc. Endoscope with protruding member and method of utilizing the same
US5746692A (en) * 1994-05-05 1998-05-05 Imagen Medical, Inc. Catheter and endoscope system with distal protruding ball tip and method
AU3274895A (en) 1994-07-18 1996-02-16 Gel Sciences, Inc. Novel polymer gel networks and methods of use
US5512294A (en) * 1994-08-05 1996-04-30 Li; King C. Targeted polymerized liposome contrast agents
US5846749A (en) * 1994-10-12 1998-12-08 The Regents Of The University Of California Quantitative measurement of tissue protein identified by immunohistochemistry and standardized protein determination
AU700903B2 (en) 1994-10-12 1999-01-14 Focal, Inc. Targeted delivery via biodegradable polymers
US5810742A (en) * 1994-10-24 1998-09-22 Transcan Research & Development Co., Ltd. Tissue characterization based on impedance images and on impedance measurements
US5660854A (en) 1994-11-28 1997-08-26 Haynes; Duncan H Drug releasing surgical implant or dressing material
US5716404A (en) 1994-12-16 1998-02-10 Massachusetts Institute Of Technology Breast tissue engineering
MX9707591A (es) 1995-04-04 1997-12-31 Novartis Ag Macromero de siloxano de eter perfluoroalquilico polimerizable.
EP0832151A2 (de) 1995-06-16 1998-04-01 Gel Sciences, Inc. Auf umweltänderungen reagierende polymernetzwerke und verfahren zu deren herstellung
ATE342295T1 (de) 1995-07-28 2006-11-15 Genzyme Corp Biologische abbaubare multiblokhydrogene und ihre verwendung wie trägerstoffe fur kontrollierte freisetzung pharmakologisch activen werstoffe und gewebekontaktmaterialen
US5763415A (en) * 1995-08-03 1998-06-09 John Hopkins University School Of Medicine Destruction of the epithelium of an exocrine gland in the prophylactic and therapeutic treatment of cancer
GB9521253D0 (en) * 1995-10-17 1995-12-20 Luthra Ajay K Biocompatible lubricious hydrophilic materials for medical devices
DE69612624T2 (de) * 1995-10-23 2001-09-13 Novartis Ag Optisches sensorsystem zur ionenstärkeunabhängigen ph-messung
CA2235616C (en) 1995-10-25 2002-08-06 William J. Seare, Jr. Porous material product and process
WO1997021441A1 (en) * 1995-12-11 1997-06-19 Mdv Technologies, Inc. Ophthalmic composition comprising polyoxyethylene-polyoxypropylene polymers
EP1704878B1 (de) 1995-12-18 2013-04-10 AngioDevice International GmbH Quervernetzte Polymerzusammensetzungen und Verfahren zu ihrer Verwendung
US5807329A (en) * 1996-05-07 1998-09-15 Gelman; Martin L. Displaceable catheter device
US5861174A (en) 1996-07-12 1999-01-19 University Technology Corporation Temperature sensitive gel for sustained delivery of protein drugs
US5785648A (en) * 1996-10-09 1998-07-28 David Min, M.D., Inc. Speculum
US6394996B1 (en) * 1997-01-07 2002-05-28 C. R. Bard, Inc. System for aspirating and irrigating tract wounds
US6083990A (en) * 1997-04-02 2000-07-04 Pharmos Corporation Enhanced anti-angiogenic activity of permanently charged derivatives of steroid hormones
KR100239308B1 (ko) * 1997-02-18 2000-01-15 전주범 적응적 윤곽선 부호화 방법 및 그 장치
DE69841937D1 (de) * 1997-04-21 2010-11-25 California Inst Of Techn Multifunctionelle polymer-beschichtung
WO1998048838A1 (en) * 1997-04-29 1998-11-05 Nycomed Imaging As Compounds
US6416740B1 (en) * 1997-05-13 2002-07-09 Bristol-Myers Squibb Medical Imaging, Inc. Acoustically active drug delivery systems
US6168779B1 (en) * 1997-09-16 2001-01-02 The Regents Of The University Of California Methods and kits for identifying ductal orifices
US6221622B1 (en) * 1998-04-28 2001-04-24 The Regents Of The University Of California Method and kit for obtaining fluids and cellular material from breast ducts
US6890311B2 (en) * 1997-09-16 2005-05-10 The Regents Of The University Of California Methods for performing medical procedures within a breast duct
US5874416A (en) * 1997-11-07 1999-02-23 Sheikhnejad; Gholamreza RAS antisense inhibition
US6171296B1 (en) * 1998-04-28 2001-01-09 Microtherapeutics, Inc. Flow directed catheter
AU758665B2 (en) * 1998-07-22 2003-03-27 Angiolink Corporation Vascular suction cannula, dilator and surgical stapler
WO2000005419A1 (en) * 1998-07-24 2000-02-03 Yeda Research And Development Company Ltd. Prevention of metastasis with 5-aza-2'-deoxycytidine
US6391026B1 (en) * 1998-09-18 2002-05-21 Pro Duct Health, Inc. Methods and systems for treating breast tissue
US20030049262A1 (en) * 1998-10-02 2003-03-13 Susan Love Methods for identification, diagnosis, and treatment of breast cancer
US20030039959A1 (en) * 1998-10-02 2003-02-27 Susan Love Methods for identification, diagnosis, and treatment of breast cancer
US6689070B2 (en) * 1998-12-28 2004-02-10 Cytyc Health Corporation Devices, methods and systems for collecting material from a breast duct
US6413228B1 (en) * 1998-12-28 2002-07-02 Pro Duct Health, Inc. Devices, methods and systems for collecting material from a breast duct
CA2360540C (en) * 1999-01-13 2008-11-04 David Hung Ductal orifice identification by characteristic electrical signal
EP1147208B1 (de) * 1999-01-20 2006-12-13 The Regents Of The University Of California Zusammensetzungen und verfahren zur intraductalen gentherapie
US6638727B1 (en) * 1999-01-26 2003-10-28 Cytyc Health Corporation Methods for identifying treating or monitoring asymptomatic patients for risk reduction or therapeutic treatment of breast cancer
IT1308711B1 (it) * 1999-02-17 2002-01-10 St Microelectronics Srl Dispositivo a commutazione con due interruttori a semi-ponte e mezziper mantenere ciascun interruttore in interdizione quando l'altro
US6398765B1 (en) * 1999-03-01 2002-06-04 Pro Duct Health, Inc. Apparatus, methods and kits for simultaneous delivery of a substance to multiple breast milk ducts
US6312725B1 (en) * 1999-04-16 2001-11-06 Cohesion Technologies, Inc. Rapid gelling biocompatible polymer composition
US6428550B1 (en) * 1999-05-18 2002-08-06 Cardica, Inc. Sutureless closure and deployment system for connecting blood vessels
DE60031114T2 (de) * 1999-06-11 2007-05-03 Cytyc Corp., Marlborough Flüssige gelformulierung zum detektieren von milchkanälen in der brust vor einer chirurgischen ablation des brustgewebes
US6589212B1 (en) * 1999-11-08 2003-07-08 Janin Group, Inc. Guide for surgical device
WO2001093917A2 (en) * 2000-06-08 2001-12-13 Cytyc Health Corporation Preparation for breast duct fluid collection
AU8116101A (en) * 2000-08-08 2002-02-18 Pro Duct Health Inc Identification of viral agents in breast ducts and antiviral therapy therefore
US20020117169A1 (en) * 2001-02-27 2002-08-29 Kurz Daniel R. Cover and applicator for a portion of a mammalian body
US20020142941A1 (en) * 2001-03-30 2002-10-03 Pro Duct Health, Inc. Intraductal treatment targeting methylated promoters in breast cancer
US20050234497A1 (en) * 2001-04-16 2005-10-20 David Hung Externally positioned medical dilator
US20020173816A1 (en) * 2001-04-16 2002-11-21 Pro Duct Health, Inc. Medical instrument with an atraumatic end
AU2003230663A1 (en) * 2002-03-15 2003-09-29 Cytyc Corporation Method of diagnosis and treatment of breast lesions
US6712798B2 (en) * 2002-03-18 2004-03-30 Corazon Technologies, Inc. Multilumen catheters and methods for their use
JP2005520649A (ja) * 2002-03-19 2005-07-14 サイティック ヘルス コーポレーション 治療用または診断用の薬剤を用いた乳房病変部の乳管内管理
US6770063B2 (en) * 2002-04-23 2004-08-03 Uresil, L.P. Thoracic vent kit
US20050027236A1 (en) * 2003-07-30 2005-02-03 Medtronic Ave, Inc. Aspiration catheter having a variable over-the-wire length and methods of use
US7276047B2 (en) * 2003-12-23 2007-10-02 Cytyc Corporation Ductal lavage microcatheter with user activated valve and Nitinol introducer
US7229420B2 (en) * 2003-12-23 2007-06-12 Cytyc Corporation Medical instrument for accessing a breast duct for performing a medical procedure
US7195601B2 (en) * 2003-12-23 2007-03-27 Cytyc Corporation Method of opening a ductal sphincter using controlled fluid pressure
US20050137499A1 (en) * 2003-12-23 2005-06-23 Sheets Ellen E. Ductal lavage catheter
US7494472B2 (en) * 2003-12-23 2009-02-24 Windy Hill Medical, Inc. Ductal lavage catheter having an off-axis tip
US20060199828A1 (en) * 2005-03-04 2006-09-07 Georg Jaeschke Pyrazine-2-carboxyamide derivatives

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US20070189968A1 (en) 2007-08-16
US6589998B1 (en) 2003-07-08
CA2375576A1 (en) 2000-12-21
AU5732200A (en) 2001-01-02
EP1185309B1 (de) 2006-10-04
IL146801A (en) 2007-09-20
EP1185309A4 (de) 2003-05-02
IL146801A0 (en) 2002-07-25
ES2273702T3 (es) 2007-05-16
US20110200695A1 (en) 2011-08-18
AU769853B2 (en) 2004-02-05
DE60031114T2 (de) 2007-05-03
WO2000076555A1 (en) 2000-12-21
EP1185309A1 (de) 2002-03-13
US20040013639A1 (en) 2004-01-22
US20130129616A1 (en) 2013-05-23
ATE341345T1 (de) 2006-10-15

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