DE60034347D1 - Vorrichtung und verfahren für hochdichte elektrophorese - Google Patents

Vorrichtung und verfahren für hochdichte elektrophorese

Info

Publication number
DE60034347D1
DE60034347D1 DE60034347T DE60034347T DE60034347D1 DE 60034347 D1 DE60034347 D1 DE 60034347D1 DE 60034347 T DE60034347 T DE 60034347T DE 60034347 T DE60034347 T DE 60034347T DE 60034347 D1 DE60034347 D1 DE 60034347D1
Authority
DE
Germany
Prior art keywords
microfluidic device
chambers
radially
high density
distal
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60034347T
Other languages
English (en)
Other versions
DE60034347T2 (de
Inventor
Timothy M Woudenberg
Reid B Kowallis
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Applied Biosystems LLC
Original Assignee
Applera Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Applera Corp filed Critical Applera Corp
Application granted granted Critical
Publication of DE60034347D1 publication Critical patent/DE60034347D1/de
Publication of DE60034347T2 publication Critical patent/DE60034347T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502753—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by bulk separation arrangements on lab-on-a-chip devices, e.g. for filtration or centrifugation
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502707—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the manufacture of the container or its components
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502723—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by venting arrangements
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/50273—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the means or forces applied to move the fluids
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L7/00—Heating or cooling apparatus; Heat insulating devices
    • B01L7/52—Heating or cooling apparatus; Heat insulating devices with provision for submitting samples to a predetermined sequence of different temperatures, e.g. for treating nucleic acid samples
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6844—Nucleic acid amplification reactions
    • C12Q1/686—Polymerase chain reaction [PCR]
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/416—Systems
    • G01N27/447—Systems using electrophoresis
    • G01N27/44756—Apparatus specially adapted therefor
    • G01N27/44782—Apparatus specially adapted therefor of a plurality of samples
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/416—Systems
    • G01N27/447—Systems using electrophoresis
    • G01N27/44756—Apparatus specially adapted therefor
    • G01N27/44791—Microapparatus
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06—Fluid handling related problems
    • B01L2200/0684—Venting, avoiding backpressure, avoid gas bubbles
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/04—Closures and closing means
    • B01L2300/041—Connecting closures to device or container
    • B01L2300/044—Connecting closures to device or container pierceable, e.g. films, membranes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/06—Auxiliary integrated devices, integrated components
    • B01L2300/0627—Sensor or part of a sensor is integrated
    • B01L2300/0645—Electrodes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0803—Disc shape
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
    • B01L2300/087—Multiple sequential chambers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0887—Laminated structure
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/12—Specific details about materials
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
    • B01L2400/0409—Moving fluids with specific forces or mechanical means specific forces centrifugal forces
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
    • B01L2400/0415—Moving fluids with specific forces or mechanical means specific forces electrical forces, e.g. electrokinetic
    • B01L2400/0421—Moving fluids with specific forces or mechanical means specific forces electrical forces, e.g. electrokinetic electrophoretic flow
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5025—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures for parallel transport of multiple samples
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/416—Systems
    • G01N27/447—Systems using electrophoresis
    • G01N27/44704—Details; Accessories
    • G01N27/44717—Arrangements for investigating the separated zones, e.g. localising zones
    • G01N27/44721—Arrangements for investigating the separated zones, e.g. localising zones by optical means
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/00029—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor provided with flat sample substrates, e.g. slides
    • G01N35/00069—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor provided with flat sample substrates, e.g. slides whereby the sample substrate is of the bio-disk type, i.e. having the format of an optical disk
DE60034347T 1999-07-16 2000-07-14 Vorrichtung und verfahren für hochdichte elektrophorese Expired - Lifetime DE60034347T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US14410399P 1999-07-16 1999-07-16
US144103P 1999-07-16
PCT/US2000/019265 WO2001006228A2 (en) 1999-07-16 2000-07-14 High density electrophoresis device and method

Publications (2)

Publication Number Publication Date
DE60034347D1 true DE60034347D1 (de) 2007-05-24
DE60034347T2 DE60034347T2 (de) 2007-12-13

Family

ID=22507050

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60034347T Expired - Lifetime DE60034347T2 (de) 1999-07-16 2000-07-14 Vorrichtung und verfahren für hochdichte elektrophorese

Country Status (8)

Country Link
US (5) US6660147B1 (de)
EP (2) EP1204861B1 (de)
JP (1) JP3990910B2 (de)
AT (1) ATE359502T1 (de)
AU (1) AU773950B2 (de)
CA (1) CA2378091A1 (de)
DE (1) DE60034347T2 (de)
WO (1) WO2001006228A2 (de)

Families Citing this family (82)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001006228A2 (en) * 1999-07-16 2001-01-25 Pe Corporation High density electrophoresis device and method
US6720187B2 (en) * 2000-06-28 2004-04-13 3M Innovative Properties Company Multi-format sample processing devices
US6734401B2 (en) * 2000-06-28 2004-05-11 3M Innovative Properties Company Enhanced sample processing devices, systems and methods
US7033475B2 (en) * 2000-10-25 2006-04-25 Shimadzu Corporation Electrophoretic apparatus
SE0004296D0 (sv) * 2000-11-23 2000-11-23 Gyros Ab Device and method for the controlled heating in micro channel systems
US20030118804A1 (en) * 2001-05-02 2003-06-26 3M Innovative Properties Company Sample processing device with resealable process chamber
US6919058B2 (en) 2001-08-28 2005-07-19 Gyros Ab Retaining microfluidic microcavity and other microfluidic structures
US20030127368A1 (en) * 2001-12-17 2003-07-10 Intel Corporation Materials classifier, method of making, and method of using
GB0130235D0 (en) * 2001-12-18 2002-02-06 Deltadot Ltd Centrifugal spectrometer
US7691244B2 (en) * 2001-12-18 2010-04-06 Massachusetts Institute Of Technology Microfluidic pumps and mixers driven by induced-charge electro-osmosis
US6532997B1 (en) 2001-12-28 2003-03-18 3M Innovative Properties Company Sample processing device with integral electrophoresis channels
US6889468B2 (en) 2001-12-28 2005-05-10 3M Innovative Properties Company Modular systems and methods for using sample processing devices
AU2003225724A1 (en) * 2002-03-11 2003-09-29 Momenta Pharmaceuticals, Inc. Analysis of sulfated polysaccharides
US7867193B2 (en) 2004-01-29 2011-01-11 The Charles Stark Draper Laboratory, Inc. Drug delivery apparatus
US7901630B2 (en) 2002-08-20 2011-03-08 Illumina, Inc. Diffraction grating-based encoded microparticle assay stick
US7508608B2 (en) 2004-11-17 2009-03-24 Illumina, Inc. Lithographically fabricated holographic optical identification element
US7619819B2 (en) 2002-08-20 2009-11-17 Illumina, Inc. Method and apparatus for drug product tracking using encoded optical identification elements
US7923260B2 (en) 2002-08-20 2011-04-12 Illumina, Inc. Method of reading encoded particles
US7164533B2 (en) 2003-01-22 2007-01-16 Cyvera Corporation Hybrid random bead/chip based microarray
US7872804B2 (en) 2002-08-20 2011-01-18 Illumina, Inc. Encoded particle having a grating with variations in the refractive index
US7900836B2 (en) 2002-08-20 2011-03-08 Illumina, Inc. Optical reader system for substrates having an optically readable code
US20040112751A1 (en) * 2002-08-26 2004-06-17 Jongyoon Han Multidimensional electrophoresis and methods of making and using thereof
US6923895B2 (en) * 2002-09-09 2005-08-02 Beckman Coulter, Inc. Coated capillary electrophoresis tubes and system
US20100255603A9 (en) 2002-09-12 2010-10-07 Putnam Martin A Method and apparatus for aligning microbeads in order to interrogate the same
US7092160B2 (en) 2002-09-12 2006-08-15 Illumina, Inc. Method of manufacturing of diffraction grating-based optical identification element
WO2004024328A1 (en) * 2002-09-12 2004-03-25 Cyvera Corporation Method and apparatus for aligning elongated microbeads in order to interrogate the same
AU2003301449A1 (en) * 2002-10-13 2004-05-04 Picosep A/S A two-dimensional microfluid biomolecule separation system
US7396650B2 (en) * 2003-06-27 2008-07-08 Commissariat A L'energie Atomique Method for dosing a biological or chemical sample
US8012328B2 (en) 2003-08-21 2011-09-06 Colorado State University Research Foundation Non-fluidic micro-detection device and uses thereof
JP4407271B2 (ja) * 2003-12-19 2010-02-03 株式会社日立製作所 チップ、反応分析装置、反応分析方法
EP1712916A4 (de) * 2003-12-26 2008-07-23 Matsushita Electric Ind Co Ltd Vorrichtung zur unterscheidung biologischer proben, verfahren zur unterscheidung biologischer proben und platte zur unterscheidung biologischer proben
US7867194B2 (en) 2004-01-29 2011-01-11 The Charles Stark Draper Laboratory, Inc. Drug delivery apparatus
US7433123B2 (en) * 2004-02-19 2008-10-07 Illumina, Inc. Optical identification element having non-waveguide photosensitive substrate with diffraction grating therein
US8105471B1 (en) * 2004-07-19 2012-01-31 Han Sang M Nanofluidics for bioseparation and analysis
US7645423B2 (en) * 2004-08-20 2010-01-12 International Business Machines Corporation Optical micro plugs for multichannel and multilayer pharmaceutical device
WO2006055736A1 (en) 2004-11-16 2006-05-26 Illumina, Inc. And methods and apparatus for reading coded microbeads
WO2006055735A2 (en) * 2004-11-16 2006-05-26 Illumina, Inc Scanner having spatial light modulator
ITPD20040301A1 (it) * 2004-11-26 2005-02-26 Dimensional Srl P Metodo ed apparato per la separazione simultanea di molecole biologiche mediante elettroforesi bidimensionale
EP2597471A3 (de) * 2005-04-01 2014-03-05 Konica Minolta Medical & Graphic, Inc. Mikrointegriertes Analysesystem, Prüfchip und Prüfverfahren
JP2006308523A (ja) * 2005-05-02 2006-11-09 Ebara Corp 電気泳動用マイクロチップのマイクロチャンネル内のコーティング方法および該方法によりコーティングが施された電気泳動用マイクロチップ
US7763210B2 (en) * 2005-07-05 2010-07-27 3M Innovative Properties Company Compliant microfluidic sample processing disks
US7323660B2 (en) 2005-07-05 2008-01-29 3M Innovative Properties Company Modular sample processing apparatus kits and modules
US7754474B2 (en) 2005-07-05 2010-07-13 3M Innovative Properties Company Sample processing device compression systems and methods
US20070131870A1 (en) * 2005-12-12 2007-06-14 Combisep Multiplexed CE fluorescence system
CN1991356B (zh) * 2005-12-31 2010-11-10 博奥生物有限公司 一种多通道毛细管电泳芯片及其电压控制方法
US7830575B2 (en) 2006-04-10 2010-11-09 Illumina, Inc. Optical scanner with improved scan time
US20100056388A1 (en) * 2006-08-21 2010-03-04 Cnvgenes, Inc. Nucleic acid array having fixed nucleic acid anti-probes and complementary free nucleic acid probes
US20080044821A1 (en) * 2006-08-21 2008-02-21 Gafur Zainiev Nucleic acid array having fixed nucleic acid anti-probes and complementary free nucleic acid probes
US20090286694A1 (en) * 2006-08-21 2009-11-19 Gafur Zainiev Nucleic acid array with releaseable nucleic acid probes
US20080044822A1 (en) * 2006-08-21 2008-02-21 Gafur Zainiev Nucleic acid array with releaseable nucleic acid probes
WO2008057043A1 (en) * 2006-11-09 2008-05-15 Gyros Patent Ab Improved lid
CN101568384B (zh) * 2006-12-22 2013-05-01 3M创新有限公司 改进的样品处理装置、系统和方法
AU2007336774A1 (en) 2006-12-22 2008-07-03 3M Innovative Properties Company Thermal transfer methods and structures for microfluidic systems
US9046192B2 (en) 2007-01-31 2015-06-02 The Charles Stark Draper Laboratory, Inc. Membrane-based fluid control in microfluidic devices
US20090075801A1 (en) * 2007-09-19 2009-03-19 Dalibor Hodko Counter-centrifugal force device
US7812318B1 (en) 2008-03-14 2010-10-12 Advanced Technology Applications, Llc Electromagnetic biosensor
US8735846B1 (en) 2008-03-14 2014-05-27 Advanced Technology Applications, Llc Electromagnetic biosensor
UY31720A1 (es) * 2008-03-19 2009-09-30 Procedimiento y aparato para separar particulas en un fluido
WO2009136232A1 (en) * 2008-05-05 2009-11-12 Korkut Celal Vata Automated, high band resolution electrophoretic system for digital visualization and method of use
JP5572939B2 (ja) * 2008-10-27 2014-08-20 株式会社島津製作所 Ｄｎａの塩基配列決定法
CA2764678C (en) 2009-06-04 2017-12-12 Lockheed Martin Corporation Multiple-sample microfluidic chip for dna analysis
US8834792B2 (en) 2009-11-13 2014-09-16 3M Innovative Properties Company Systems for processing sample processing devices
USD638951S1 (en) 2009-11-13 2011-05-31 3M Innovative Properties Company Sample processing disk cover
USD638550S1 (en) 2009-11-13 2011-05-24 3M Innovative Properties Company Sample processing disk cover
USD667561S1 (en) 2009-11-13 2012-09-18 3M Innovative Properties Company Sample processing disk cover
TW201122460A (en) * 2009-12-31 2011-07-01 Ind Tech Res Inst Surface plasmon resonance unit and inspection system using the same
FR2955268B1 (fr) * 2010-01-20 2019-06-28 Apex Biosolutions Dispositif de repartition, notamment pour un echantillon biologique
CN102262051B (zh) 2010-05-25 2015-04-08 香港城市大学 光学传感装置和使用该光学传感装置检测样本的方法
JP2012029676A (ja) * 2010-07-07 2012-02-16 Sony Corp 核酸濃縮回収用カートリッジ、核酸濃縮回収方法、及び該カートリッジの製造方法
CA2814720C (en) 2010-10-15 2016-12-13 Lockheed Martin Corporation Micro fluidic optic design
US8876795B2 (en) 2011-02-02 2014-11-04 The Charles Stark Draper Laboratory, Inc. Drug delivery apparatus
AU2012255144B2 (en) 2011-05-18 2015-01-29 Diasorin Italia S.P.A. Systems and methods for volumetric metering on a sample processing device
US9168523B2 (en) 2011-05-18 2015-10-27 3M Innovative Properties Company Systems and methods for detecting the presence of a selected volume of material in a sample processing device
JP2014517291A (ja) 2011-05-18 2014-07-17 スリーエム イノベイティブ プロパティズ カンパニー サンプル処理装置のバルブ動作のためのシステム及び方法
USD672467S1 (en) 2011-05-18 2012-12-11 3M Innovative Properties Company Rotatable sample processing disk
KR101881451B1 (ko) 2011-06-29 2018-07-25 삼성전자주식회사 유체내 기체 제거를 위한 미세유체 채널
US10384209B2 (en) 2011-09-15 2019-08-20 The Chinese University Of Hong Kong Microfluidic platform and method for controlling the same
US9322054B2 (en) 2012-02-22 2016-04-26 Lockheed Martin Corporation Microfluidic cartridge
US8953168B2 (en) 2012-06-08 2015-02-10 City University Of Hong Kong Optical sensing devices and methods for detecting samples using the same
US20140017806A1 (en) * 2012-07-11 2014-01-16 Samsung Electronics Co., Ltd. Microfluidic structure, microfluidic device having the same and method of controlling the microfluidic device
US9192934B2 (en) * 2012-10-25 2015-11-24 General Electric Company Insert assembly for a microfluidic device
EP3519098A1 (de) * 2016-09-29 2019-08-07 Qiagen Lake Constance GmbH Probenbehälteranordnung

Family Cites Families (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US1016097A (en) * 1908-04-20 1912-01-30 Charles C Ruprecht Process of purifying electrically-conductive materials.
US3556967A (en) * 1968-08-29 1971-01-19 Atomic Energy Commission Electrophoretic separation utilizing liquid centrifuge
IT1097442B (it) * 1977-08-18 1985-08-31 Guigan Jean Dispositivo di condizionamento di un campione di liquido in preparazione della sua analisi
US4337131A (en) 1978-11-13 1982-06-29 C. Desaga Gmbh Nachf. Erich Fecht Process for electrophoresis
US4417967A (en) 1981-11-24 1983-11-29 Georgetown University Grooved gel
EP0138763B1 (de) * 1983-10-04 1989-01-18 IntraCel Corporation Verfahren zum Giessen von bei der Dünnschicht-Elektrophorese verwendbaren Gelen
GB8401510D0 (en) 1984-01-20 1984-02-22 Atomic Energy Authority Uk Electrophoretic separator
CH655672B (de) * 1984-02-22 1986-05-15
US4670119A (en) 1985-10-25 1987-06-02 Hurd Stanley M Isoelectric focusing device and process
EP0376611A3 (de) 1988-12-30 1992-07-22 The Board Of Trustees Of The Leland Stanford Junior University Elektroforetische Vorrichtung
US4973168A (en) * 1989-01-13 1990-11-27 Chan Kwan Ho Vacuum mixing/bone cement cartridge and kit
US5313129A (en) * 1993-08-05 1994-05-17 Ametek Technical Motor Division Sleeve bearing ground lead for motors
US5409665A (en) 1993-09-01 1995-04-25 Abaxis, Inc. Simultaneous cuvette filling with means to isolate cuvettes
US5591643A (en) 1993-09-01 1997-01-07 Abaxis, Inc. Simplified inlet channels
US5639428A (en) * 1994-07-19 1997-06-17 Becton Dickinson And Company Method and apparatus for fully automated nucleic acid amplification, nucleic acid assay and immunoassay
US6001229A (en) 1994-08-01 1999-12-14 Lockheed Martin Energy Systems, Inc. Apparatus and method for performing microfluidic manipulations for chemical analysis
US5483075A (en) 1994-11-01 1996-01-09 Perkin-Elmer Corporation Rotary scanning apparatus
US5585069A (en) * 1994-11-10 1996-12-17 David Sarnoff Research Center, Inc. Partitioned microelectronic and fluidic device array for clinical diagnostics and chemical synthesis
US5856174A (en) * 1995-06-29 1999-01-05 Affymetrix, Inc. Integrated nucleic acid diagnostic device
US5872010A (en) * 1995-07-21 1999-02-16 Northeastern University Microscale fluid handling system
CA2239613A1 (en) * 1995-12-05 1997-06-12 Alec Mian Devices and methods for using centripetal acceleration to drive fluid movement in a microfluidics system with on-board informatics
US20010055812A1 (en) * 1995-12-05 2001-12-27 Alec Mian Devices and method for using centripetal acceleration to drive fluid movement in a microfluidics system with on-board informatics
DE69700499T2 (de) * 1996-04-03 2000-03-23 Perkin Elmer Corp Vorrichtung und verfahren zum nachweis mehrerer analyten
AUPO652997A0 (en) * 1997-04-30 1997-05-29 Kindconi Pty Limited Temperature cycling device and method
US6063589A (en) 1997-05-23 2000-05-16 Gamera Bioscience Corporation Devices and methods for using centripetal acceleration to drive fluid movement on a microfluidics system
WO1999014368A2 (en) * 1997-09-15 1999-03-25 Whitehead Institute For Biomedical Research Methods and apparatus for processing a sample of biomolecular analyte using a microfabricated device
US6126804A (en) * 1997-09-23 2000-10-03 The Regents Of The University Of California Integrated polymerase chain reaction/electrophoresis instrument
US6013513A (en) * 1997-10-30 2000-01-11 Motorola, Inc. Molecular detection apparatus
US6143152A (en) 1997-11-07 2000-11-07 The Regents Of The University Of California Microfabricated capillary array electrophoresis device and method
US6100535A (en) * 1998-01-29 2000-08-08 The Regents Of The University Of California Rotary confocal scanner for detection of capillary arrays
GB9802600D0 (en) * 1998-02-07 1998-04-01 Eastman Kodak Co Liquid separation
WO2001006228A2 (en) * 1999-07-16 2001-01-25 Pe Corporation High density electrophoresis device and method

Also Published As

Publication number Publication date
DE60034347T2 (de) 2007-12-13
WO2001006228A3 (en) 2001-08-09
US6660147B1 (en) 2003-12-09
EP1813683A1 (de) 2007-08-01
US20040178074A1 (en) 2004-09-16
EP1204861B1 (de) 2007-04-11
WO2001006228A2 (en) 2001-01-25
CA2378091A1 (en) 2001-01-25
ATE359502T1 (de) 2007-05-15
EP1204861A4 (de) 2005-04-27
US20090317824A1 (en) 2009-12-24
AU6490300A (en) 2001-02-05
JP2003504637A (ja) 2003-02-04
JP3990910B2 (ja) 2007-10-17
US20110124002A1 (en) 2011-05-26
US7491305B2 (en) 2009-02-17
AU773950B2 (en) 2004-06-10
EP1204861A2 (de) 2002-05-15
US20070128652A1 (en) 2007-06-07

Similar Documents

Publication Publication Date Title
DE60034347D1 (de) Vorrichtung und verfahren für hochdichte elektrophorese
JP7072396B2 (ja) 封止可能な熱サイクル用微少流体チップ
CA2250212C (en) Device and method for multiple analyte detection
FI892926A0 (fi) Menetelmä solukomponenttien analysoimiseksi nesteestä
WO2001043871A3 (en) Microarray hybridization chamber
DE69033796D1 (de) Verfahren und gerät zum nachweis und zur quantifizierung von glukose in körperflüssigkeiten
ATE260988T1 (de) Vorrichtung und verfahren zur durchführung und überwachung von polymerase kettenreaktionen
US20080102462A1 (en) Device and method for multiple analyte detection
DE69823673D1 (de) Vorrichtung und verfahren zur tropfenmikrochemie
ATE457197T1 (de) Testvorrichtung und verfahren zur verwendung
IL129767A0 (en) Apparatus and method for detecting and identifying infectious agents
CA2156226A1 (en) Biological Fluid Analyzing Device and Method
AR015206A1 (es) APARATO PARA DETERMINAR LA CONCENTRACIoN DE UN COMPONENTE MEDICAMENTE SIGNIFICATIVO DE UN FLUíDO BIOLoGICO Y MÉTODO APLICADO EN EL MISMO.
ATE220426T1 (de) Verfahren zur direkten, exponentiellen amplifikation und sequenzierung von dna-molekülen und seine anwendung
DE3381518D1 (de) Verfahren zur charakterisierung von hla und die darin benutzten cdns-testmittel.
WO2005075683A1 (en) High throughput device for performing continuous-flow reactions
Rodriguez et al. Practical integration of polymerase chain reaction amplification and electrophoretic analysis in microfluidic devices for genetic analysis
JPH1033173A (ja) Ｄｎａ試料調整装置及びこれを用いる電気泳動分析装置
DK328084A (da) In vivo maerkning af polynukleotid-sekvenser
JP2010213649A (ja) 生体試料反応容器及び生体試料反応方法
JP2008521432A (ja) サンプル分析方法及びそのための装置
CA2252571A1 (en) Method and apparatus for thermal cycling and for automated sample preparation with thermal cycling
US20030148535A1 (en) Method for producing a test sample card
DK0689038T3 (da) Ikke-invasiv metode til bestemmelse af tilbageværende mængder af flydende reagenser
Brahmasandra Microfabricated separation systems for integrated DNA analysis

Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8327 Change in the person/name/address of the patent owner

Owner name: APPLIED BIOSYSTEMS, LLC (N. D. GES. D. STAATES, US

8380 Miscellaneous part iii

Free format text: PFANDRECHT

8380 Miscellaneous part iii

Free format text: PFANDRECHT AUFGEHOBEN