DE60039253D1 - Überwachung von oligonukleotidenbindung durch chemilumineszenzlöschung - Google Patents

Überwachung von oligonukleotidenbindung durch chemilumineszenzlöschung

Info

Publication number
DE60039253D1
DE60039253D1 DE60039253T DE60039253T DE60039253D1 DE 60039253 D1 DE60039253 D1 DE 60039253D1 DE 60039253 T DE60039253 T DE 60039253T DE 60039253 T DE60039253 T DE 60039253T DE 60039253 D1 DE60039253 D1 DE 60039253D1
Authority
DE
Germany
Prior art keywords
quencher
chemiluminescence
deletion
monitoring
oligonucleotide
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60039253T
Other languages
English (en)
Inventor
Andrew James Rutter
Ian Weeks
Zhaoqiang Li
Keith Smith
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Gen Probe Cardiff Ltd
Original Assignee
Molecular Light Technology Ltd
Molecular Light Technology Research Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Molecular Light Technology Ltd, Molecular Light Technology Research Ltd filed Critical Molecular Light Technology Ltd
Application granted granted Critical
Publication of DE60039253D1 publication Critical patent/DE60039253D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6816—Hybridisation assays characterised by the detection means
    • C12Q1/6818—Hybridisation assays characterised by the detection means involving interaction of two or more labels, e.g. resonant energy transfer

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Analytical Chemistry (AREA)
  • Biotechnology (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
DE60039253T 1999-12-10 2000-12-11 Überwachung von oligonukleotidenbindung durch chemilumineszenzlöschung Expired - Lifetime DE60039253D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB9929148A GB2359625B (en) 1999-12-10 1999-12-10 Monitoring oligonucleotide binding process using chemiluminescence quenching
PCT/GB2000/004721 WO2001042497A2 (en) 1999-12-10 2000-12-11 Monitoring oligonucleotide binding processes using chemiluminescence quenching

Publications (1)

Publication Number Publication Date
DE60039253D1 true DE60039253D1 (de) 2008-07-31

Family

ID=10866027

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60039253T Expired - Lifetime DE60039253D1 (de) 1999-12-10 2000-12-11 Überwachung von oligonukleotidenbindung durch chemilumineszenzlöschung

Country Status (11)

Country Link
US (1) US7169554B2 (de)
EP (1) EP1242622B1 (de)
JP (1) JP4722363B2 (de)
AT (1) ATE398682T1 (de)
AU (1) AU782674B2 (de)
CA (1) CA2393575C (de)
DE (1) DE60039253D1 (de)
DK (1) DK1242622T3 (de)
ES (1) ES2304993T3 (de)
GB (1) GB2359625B (de)
WO (1) WO2001042497A2 (de)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2359625B (en) 1999-12-10 2004-10-20 Molecular Light Tech Res Ltd Monitoring oligonucleotide binding process using chemiluminescence quenching
US7291457B2 (en) * 2001-06-21 2007-11-06 The Regents Of The University Of California Electrochemical detection of mismatch nucleic acids
US6892092B2 (en) * 2001-10-29 2005-05-10 Cardiac Pacemakers, Inc. Cardiac rhythm management system with noise detector utilizing a hysteresis providing threshold
GB0320235D0 (en) * 2003-08-29 2003-10-01 Molecular Light Tech Res Ltd Estimation of activity or inhibition of processes involved in nucleic acid modification using chemiluminescence quenching
US8628924B2 (en) 2009-07-21 2014-01-14 Gen-Probe Incorporated Methods and compositions for quantitative amplification and detection over a wide dynamic range
WO2019116234A1 (en) 2017-12-12 2019-06-20 Nestec S.A. Methods for determining microbiome ribosomal rna composition changes

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CA1190838A (en) 1981-07-17 1985-07-23 Cavit Akin Homogeneous nucleic acid hybridization diagnostics by non-radiative energy transfer
US4996143A (en) * 1985-12-23 1991-02-26 Syngene, Inc. Fluorescent stokes shift probes for polynucleotide hybridization
DE3785591T2 (de) * 1986-01-10 1993-09-02 Amoco Corp Kompetitiver homogener test.
CA2033692A1 (en) 1990-01-25 1991-07-26 Wilhelm Bannwarth Energy transfer systems
EP2423322A1 (de) 1993-11-12 2012-02-29 PHRI Properties, Inc. Hybridisierungsprobe zur Nukleinsäuredetektion, universelle Stammstrukturen, Methoden und Reagentiensätze
US5925517A (en) * 1993-11-12 1999-07-20 The Public Health Research Institute Of The City Of New York, Inc. Detectably labeled dual conformation oligonucleotide probes, assays and kits
US5538848A (en) 1994-11-16 1996-07-23 Applied Biosystems Division, Perkin-Elmer Corp. Method for detecting nucleic acid amplification using self-quenching fluorescence probe
ATE340866T1 (de) * 1994-10-28 2006-10-15 Gen Probe Inc Zusammensetzungen und verfahren für die gleichzeitige detektion und quantifizierung von einer mehrheit spezifischer nuklein säure sequenzen
DE19502788C1 (de) * 1995-01-28 1996-09-05 Metallgesellschaft Ag Verfahren und Vorrichtung zum Ableiten eines heißen, Kohlenmonoxid enthaltenden Gasgemisches
EP0826066B1 (de) * 1995-05-05 2000-09-13 The Perkin-Elmer Corporation Methoden and reagentien fuer die kombination einer pcr-amplifizierung mit einem hybridisierungs-assay
US5783453A (en) * 1995-06-29 1998-07-21 Chiron Diagnostics Corporation Non-separation specific binding chemiluminescent assay
JP3898228B2 (ja) * 1996-04-12 2007-03-28 ザ パブリック ヘルス リサーチ インスティチュート オブ ザ シティー オブ ニューヨーク インク 検出プローブ、キット及びアッセイ
US5866336A (en) * 1996-07-16 1999-02-02 Oncor, Inc. Nucleic acid amplification oligonucleotides with molecular energy transfer labels and methods based thereon
US6117635A (en) * 1996-07-16 2000-09-12 Intergen Company Nucleic acid amplification oligonucleotides with molecular energy transfer labels and methods based thereon
US5691145A (en) * 1996-08-27 1997-11-25 Becton, Dickinson And Company Detection of nucleic acids using G-quartets
JP3016759B2 (ja) 1997-02-28 2000-03-06 スミスクライン・ビーチャム・コーポレイション 競争的ハイブリダイゼーションによる蛍光エネルギー転移
US7314711B2 (en) * 1997-05-23 2008-01-01 Bioveris Corporation Assays employing electrochemiluminescent labels and electrochemiluminescence quenchers
AU9220498A (en) 1997-09-04 1999-03-22 Bayer Corporation Oligonucleotide probes bearing quenchable fluorescent labels, and methods of usethereof
US5935791A (en) * 1997-09-23 1999-08-10 Becton, Dickinson And Company Detection of nucleic acids by fluorescence quenching
US6485901B1 (en) 1997-10-27 2002-11-26 Boston Probes, Inc. Methods, kits and compositions pertaining to linear beacons
AU1366299A (en) 1997-10-27 1999-05-17 Boston Probes, Inc. Methods, kits and compositions pertaining to pna molecular beacons
EP0988400A1 (de) * 1998-02-18 2000-03-29 Dade Behring Inc. Methoden zur quantifizierung von nukleinsäuren
DE19808884A1 (de) 1998-03-03 1999-09-16 November Ag Molekulare Medizin Vorrichtung und Verfahren zum Nachweis chemischer Substanzen
US6361942B1 (en) 1998-03-24 2002-03-26 Boston Probes, Inc. Method, kits and compositions pertaining to detection complexes
WO2000001850A2 (en) * 1998-07-02 2000-01-13 Gen-Probe Incorporated Molecular torches
WO2000079009A2 (en) 1999-06-22 2000-12-28 Invitrogen Corporation Improved primers and methods for the detection and discrimination of nucleic acids
US6783948B1 (en) * 1999-07-30 2004-08-31 Bayer Corporation Chemiluminescent acridinium compounds and analogues thereof as substrates of hydrolytic enzymes
GB2359625B (en) 1999-12-10 2004-10-20 Molecular Light Tech Res Ltd Monitoring oligonucleotide binding process using chemiluminescence quenching

Also Published As

Publication number Publication date
WO2001042497A3 (en) 2001-12-27
AU782674B2 (en) 2005-08-18
WO2001042497A9 (en) 2002-06-06
JP2003516160A (ja) 2003-05-13
US20030082713A1 (en) 2003-05-01
WO2001042497A2 (en) 2001-06-14
GB9929148D0 (en) 2000-02-02
AU2193301A (en) 2001-06-18
ATE398682T1 (de) 2008-07-15
CA2393575C (en) 2012-01-31
GB2359625A (en) 2001-08-29
DK1242622T3 (da) 2008-09-08
CA2393575A1 (en) 2001-06-14
EP1242622B1 (de) 2008-06-18
ES2304993T3 (es) 2008-11-01
US7169554B2 (en) 2007-01-30
EP1242622A2 (de) 2002-09-25
JP4722363B2 (ja) 2011-07-13
GB2359625B (en) 2004-10-20

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Legal Events

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8364 No opposition during term of opposition
8327 Change in the person/name/address of the patent owner

Owner name: GEN-PROBE CARDIFF LTD., LLANISHEN, CARDIFF, GB