DE60102359D1 - Verfahren und zusammensetzung für organ- und gewebekonservierung sowie für hypothermischen blutersatz - Google Patents
Verfahren und zusammensetzung für organ- und gewebekonservierung sowie für hypothermischen blutersatzInfo
- Publication number
- DE60102359D1 DE60102359D1 DE60102359T DE60102359T DE60102359D1 DE 60102359 D1 DE60102359 D1 DE 60102359D1 DE 60102359 T DE60102359 T DE 60102359T DE 60102359 T DE60102359 T DE 60102359T DE 60102359 D1 DE60102359 D1 DE 60102359D1
- Authority
- DE
- Germany
- Prior art keywords
- hypothermal
- organic
- composition
- tissue preservation
- blood set
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N1/00—Preservation of bodies of humans or animals, or parts thereof
- A01N1/02—Preservation of living parts
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N1/00—Preservation of bodies of humans or animals, or parts thereof
- A01N1/02—Preservation of living parts
- A01N1/0205—Chemical aspects
- A01N1/021—Preservation or perfusion media, liquids, solids or gases used in the preservation of cells, tissue, organs or bodily fluids
- A01N1/0221—Freeze-process protecting agents, i.e. substances protecting cells from effects of the physical process, e.g. cryoprotectants, osmolarity regulators like oncotic agents
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US17915300P | 2000-01-31 | 2000-01-31 | |
US179153P | 2000-01-31 | ||
US09/628,311 US6492103B1 (en) | 2000-01-31 | 2000-07-28 | System for organ and tissue preservation and hypothermic blood substitution |
US628311 | 2000-07-28 | ||
PCT/US2001/002237 WO2001054495A1 (en) | 2000-01-31 | 2001-01-24 | System for organ and tissue preservation and hypothermic blood substitution |
Publications (2)
Publication Number | Publication Date |
---|---|
DE60102359D1 true DE60102359D1 (de) | 2004-04-22 |
DE60102359T2 DE60102359T2 (de) | 2005-03-10 |
Family
ID=26875055
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE60102359T Expired - Lifetime DE60102359T2 (de) | 2000-01-31 | 2001-01-24 | Verfahren und zusammensetzung für organ- und gewebekonservierung sowie für hypothermischen blutersatz |
Country Status (7)
Country | Link |
---|---|
US (2) | US6492103B1 (de) |
EP (1) | EP1257169B1 (de) |
JP (1) | JP2003520859A (de) |
AU (2) | AU3109501A (de) |
CA (1) | CA2398614A1 (de) |
DE (1) | DE60102359T2 (de) |
WO (1) | WO2001054495A1 (de) |
Families Citing this family (87)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8409846B2 (en) | 1997-09-23 | 2013-04-02 | The United States Of America As Represented By The Department Of Veteran Affairs | Compositions, methods and devices for maintaining an organ |
US7250292B2 (en) * | 2000-01-26 | 2007-07-31 | 21St Century Medicine | Hypertonic reduction of chilling injury |
GB0028414D0 (en) | 2000-11-22 | 2001-01-03 | Univ Leeds | Flush preservation solution |
DE50201240D1 (de) * | 2001-04-23 | 2004-11-11 | Amaxa Gmbh | Pufferlössung für die elektroporation und verfahren umfassend die verwendung derselben |
US20040202993A1 (en) * | 2003-04-10 | 2004-10-14 | Poo Ramon E. | Apparatus and method for organ preservation and transportation |
US7897327B2 (en) * | 2003-06-02 | 2011-03-01 | Organ Recovery Systems, Inc. | Method and apparatus for pressure control for maintaining viability of organs |
WO2005041655A1 (en) * | 2003-10-22 | 2005-05-12 | Fred Hutchinson Cancer Research Center | Methods, compositions and devices for inducing stasis in cells, tissues, organs, and organisms |
US20050136125A1 (en) * | 2003-10-22 | 2005-06-23 | Roth Mark B. | Methods, compositions and devices for inducing stasis in cells, tissues, organs, and organisms |
US20050170019A1 (en) * | 2003-10-22 | 2005-08-04 | Fred Hutchinson Cancer Research Center | Methods, compositions and devices for inducing stasis in cells |
US7504201B2 (en) * | 2004-04-05 | 2009-03-17 | Organ Recovery Systems | Method for perfusing an organ and for isolating cells from the organ |
US9301519B2 (en) | 2004-10-07 | 2016-04-05 | Transmedics, Inc. | Systems and methods for ex-vivo organ care |
US8304181B2 (en) | 2004-10-07 | 2012-11-06 | Transmedics, Inc. | Method for ex-vivo organ care and for using lactate as an indication of donor organ status |
NZ746484A (en) | 2004-10-07 | 2020-04-24 | Transmedics Inc | Systems and methods for ex-vivo organ care |
US7713686B2 (en) * | 2004-12-03 | 2010-05-11 | Biorep Technologies, Inc. | Organ preservation container and method |
PT1879599E (pt) | 2005-04-20 | 2014-01-23 | Hutchinson Fred Cancer Res | Métodos, composições e artigos de fabrico para aumentar a capacidade de sobrevivência de células, tecidos, órgãos, e organismos |
US9078428B2 (en) | 2005-06-28 | 2015-07-14 | Transmedics, Inc. | Systems, methods, compositions and solutions for perfusing an organ |
US20070048725A1 (en) * | 2005-08-25 | 2007-03-01 | Arrington Ben O'mar | Machine perfusion of tissue grafts for transplantation |
US20070098695A1 (en) * | 2005-10-31 | 2007-05-03 | Deolden James | Methods of islet separation during isolation |
WO2007112986A1 (en) * | 2006-03-31 | 2007-10-11 | Adenobio N.V. | Compositions, methods, and kits using adenosine and inosine in combination for diagnosis and treatment |
DK3178319T3 (da) | 2006-04-19 | 2020-02-03 | Transmedics Inc | Systemer til ex vivo-organpleje |
US7790437B2 (en) * | 2006-12-14 | 2010-09-07 | Biorep Technologies, Inc. | Organ transportation device |
EP2124539A2 (de) | 2007-02-17 | 2009-12-02 | President and Fellows of Harvard College | Zusammensetzungen und verfahren zur gewebekonservierung |
CN101677526B (zh) | 2007-03-01 | 2014-07-09 | 生命线科学有限公司 | 灌注调节 |
US9457179B2 (en) | 2007-03-20 | 2016-10-04 | Transmedics, Inc. | Systems for monitoring and applying electrical currents in an organ perfusion system |
US7892724B2 (en) | 2007-07-12 | 2011-02-22 | Warsaw Orthopedic, Inc | Method for enhancing the viability of mammalian cells, tissues and organs using a solution comprising two low molecular weight PEGs |
US7960098B2 (en) * | 2007-07-12 | 2011-06-14 | Warsaw Orthoperic, Inc. | Methods and compositions for the preservation of cells and tissues |
US8835104B2 (en) | 2007-12-20 | 2014-09-16 | Fenwal, Inc. | Medium and methods for the storage of platelets |
US8420380B2 (en) | 2008-01-31 | 2013-04-16 | Transmedics, Inc. | Systems and methods for ex vivo lung care |
AU2009215883A1 (en) | 2008-02-15 | 2009-08-27 | President And Fellows Of Harvard College | Blood substitute solution |
AU2009228141A1 (en) | 2008-03-27 | 2009-10-01 | Biolife Solutions, Inc. | Mehtod, system, and apparatus for hypothermic collection, storage, transport and banking of birth tissue |
US20090263780A1 (en) * | 2008-04-17 | 2009-10-22 | Yanming Wang | Organ preservation fluid |
US20100081927A1 (en) * | 2008-09-29 | 2010-04-01 | Searete Llc, A Limited Liability Corporation Of The State Of Delaware | Histological facilitation systems and methods |
US20100081926A1 (en) * | 2008-09-29 | 2010-04-01 | Searete Llc, A Limited Liability Corporation Of The State Of Delaware | Histological facilitation systems and methods |
US20100081915A1 (en) * | 2008-09-29 | 2010-04-01 | Searete Llc, Alimited Liability Corporation Of The State Of Delaware | Histological facilitation systems and methods |
US20100081924A1 (en) * | 2008-09-29 | 2010-04-01 | Searete Llc, A Limited Liability Corporation Of The State Of Delaware | Histological facilitation systems and methods |
US20100081916A1 (en) * | 2008-09-29 | 2010-04-01 | Searete Llc, A Limited Liability Corporation Of The State Of Delaware. | Histological facilitation systems and methods |
ES2743693T3 (es) | 2009-04-29 | 2020-02-20 | Biolife Solutions Inc | Aparatos y composiciones para crioconservación de monocapas celulares |
US9357764B2 (en) | 2009-06-18 | 2016-06-07 | Giner, Inc. | System for fluid perfusion of biological matter comprising tissue |
US10091985B2 (en) * | 2009-06-18 | 2018-10-09 | Giner, Inc. | Perfusing an organ with an in situ generated gas |
KR101092411B1 (ko) * | 2009-07-22 | 2011-12-09 | (주)시지바이오 | 이식용 동종 피부의 처리 방법 및 그로부터 제조된 동결보존동종피부 |
WO2011103114A1 (en) * | 2010-02-17 | 2011-08-25 | Hememics Biotechnologies, Inc. | Preservation solutions for biologics and methods related thereto |
EP2593116B1 (de) | 2010-07-16 | 2016-06-29 | Lifeline Scientific, Inc. | Verfahren zur erhöhung der isolationswirkung von zellprodukten |
WO2012027787A1 (en) * | 2010-09-01 | 2012-03-08 | Organ Perfusion Pty Limited | Perfusion composition |
JP6073794B2 (ja) | 2010-10-22 | 2017-02-01 | ライフライン サイエンティフィック インコーポレイテッドLifeline Scientific, Inc. | 培養膵島 |
US20120148542A1 (en) | 2010-12-10 | 2012-06-14 | Lifeline Scientific, Inc. | Machine perfusion with complement inhibitors |
US8828710B2 (en) | 2011-03-15 | 2014-09-09 | Paragonix Technologies, Inc. | System for hypothermic transport of samples |
US9867368B2 (en) | 2011-03-15 | 2018-01-16 | Paragonix Technologies, Inc. | System for hypothermic transport of samples |
EP2685814B1 (de) | 2011-03-15 | 2016-08-17 | Paragonix Technologies, Inc. | Vorrichtung zur sauerstoffanreicherung und perfusion von gewebe zur organkonservierung |
US11178866B2 (en) | 2011-03-15 | 2021-11-23 | Paragonix Technologies, Inc. | System for hypothermic transport of samples |
US9426979B2 (en) | 2011-03-15 | 2016-08-30 | Paragonix Technologies, Inc. | Apparatus for oxygenation and perfusion of tissue for organ preservation |
US9253976B2 (en) | 2011-03-15 | 2016-02-09 | Paragonix Technologies, Inc. | Methods and devices for preserving tissues |
JP2014518547A (ja) | 2011-04-07 | 2014-07-31 | フェンウォール、インコーポレイテッド | 削減された残存血漿容積を有する血小板濃縮物を提供するための自動化方法とシステムおよびそのような血小板濃縮物のための貯蔵媒体 |
ES2913104T3 (es) | 2011-04-14 | 2022-05-31 | Transmedics Inc | Solución de cuidado de órganos para perfusión en máquina ex-vivo de pulmones de donantes |
CA2838537C (en) | 2011-06-09 | 2020-09-29 | Lifeline Scientific, Inc. | Data record for organ transport and/or storage, comprising biomarker and events information |
US10676780B2 (en) | 2011-09-26 | 2020-06-09 | Qiagen Gmbh | Stabilisation and isolation of extracellular nucleic acids |
US11021733B2 (en) | 2011-09-26 | 2021-06-01 | Qiagen Gmbh | Stabilization and isolation of extracellular nucleic acids |
EP2809152B1 (de) | 2012-02-01 | 2019-11-20 | Nayacure Therapeutics Ltd | Verfahren zur induktion von immuntoleranz bei organtransplantationen |
US8785116B2 (en) | 2012-08-10 | 2014-07-22 | Paragonix Technologies, Inc. | Methods for evaluating the suitability of an organ for transplant |
US9560846B2 (en) | 2012-08-10 | 2017-02-07 | Paragonix Technologies, Inc. | System for hypothermic transport of biological samples |
WO2014049022A1 (en) | 2012-09-25 | 2014-04-03 | Qiagen Gmbh | Stabilisation of biological samples |
US10433538B2 (en) | 2012-10-12 | 2019-10-08 | University of Pittsburgh—of the Commonwealth System of Higher Education | Compositions and methods for organ preservation |
US20140278468A1 (en) | 2013-03-15 | 2014-09-18 | I.D. Therapeutics Llc | Apparatus and method for optimizing treatment using medication compliance patterns and glucose sensor |
US10420337B2 (en) | 2013-03-15 | 2019-09-24 | Lifeline Scientific, Inc. | Transporter with a glucose sensor for determining viability of an organ or tissue |
CN105164258B (zh) | 2013-03-18 | 2021-05-18 | 凯杰有限公司 | 细胞外核酸的稳定化和分离 |
JP6381628B2 (ja) | 2013-03-18 | 2018-08-29 | キアゲン ゲーエムベーハー | 生物試料の安定化 |
CN105407716A (zh) * | 2013-04-29 | 2016-03-16 | 索玛解有限公司 | 用于增加器官和组织保存溶液的氧含量、稳定性和保存期的含聚(o-2-羟乙基)淀粉的制剂 |
JP6749239B2 (ja) | 2013-09-24 | 2020-09-02 | ガイナー ライフ サイエンシズ,インク. | 細胞インプラントのガス処理用システム |
CN111849955A (zh) * | 2014-03-18 | 2020-10-30 | 凯杰有限公司 | 胞外核酸的固定和分离 |
IL310657A (en) | 2014-06-02 | 2024-04-01 | Transmedics Inc | Extracorporeal system for organ treatment |
CN115813947A (zh) | 2014-07-11 | 2023-03-21 | 有氧运动系统制药有限责任公司 | 通用心脏麻痹液(多种变型) |
EP3177140B1 (de) | 2014-07-29 | 2022-07-06 | 21St Century Medicine, Inc. | Verfahren zur einführung und entfernung hoher konzentrationen von gefrierschutzmitteln durch vaskuläre perfusion |
US20160095307A1 (en) * | 2014-10-07 | 2016-04-07 | NuTech Medical, Inc. | Method and composition for hypothermic storage of placental tissue |
USD765874S1 (en) | 2014-10-10 | 2016-09-06 | Paragonix Technologies, Inc. | Transporter for a tissue transport system |
WO2016090498A1 (en) | 2014-12-12 | 2016-06-16 | Freed Darren | Apparatus and method for organ perfusion |
CA2981588A1 (en) * | 2015-04-03 | 2016-10-06 | Tx Innovations B.V. | Organ preservation composition |
IL310004A (en) | 2015-09-09 | 2024-03-01 | Transmedics Inc | A tube and a catheter for a system to treat organs outside the body |
SI3365432T1 (sl) * | 2015-10-23 | 2020-08-31 | Rigshospitalet | Terapija z matičnimi celicami, na osnovi matičnih celic iz adipoze |
CN114457068A (zh) | 2015-11-20 | 2022-05-10 | 凯杰有限公司 | 用于稳定细胞外核酸的已灭菌组合物的制备方法 |
CA3043363C (en) | 2016-11-15 | 2021-06-22 | Giner Life Sciences, Inc. | Self-regulating electrolytic gas generator and implant system comprising the same |
EP3541449B1 (de) | 2016-11-15 | 2021-11-10 | Giner Life Sciences, Inc. | Perkutane gasdiffusionsvorrichtung zur verwendung mit einem subkutanen implantat |
DK3448149T3 (da) * | 2017-01-17 | 2019-11-04 | Xvivo Perfusion Ab | Organkonserverings- og/eller perfusionsopløsninger |
EP3634127A4 (de) | 2017-06-07 | 2021-03-17 | Paragonix Technologies Inc. | Vorrichtung zum transport und zur konservierung von gewebe |
CN107926933B (zh) * | 2018-01-14 | 2021-04-23 | 上海慧存医疗科技有限公司 | 一种细胞保存液 |
JP2021523981A (ja) | 2018-05-17 | 2021-09-09 | ガイナー ライフ サイエンシズ,インク. | リードターミナルとガスポートターミナルとを組み合わせた電解ガス発生装置 |
US11452618B2 (en) | 2019-09-23 | 2022-09-27 | Dimicron, Inc | Spinal artificial disc removal tool |
US11632951B2 (en) | 2020-01-31 | 2023-04-25 | Paragonix Technologies, Inc. | Apparatus for tissue transport and preservation |
CN114457003A (zh) | 2020-11-10 | 2022-05-10 | 维思尔治疗有限公司 | 预调节血管细胞用于转导的方法、转导方法和保存转导的细胞的方法 |
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DE2532183C3 (de) | 1975-07-18 | 1982-03-04 | Behringwerke Ag, 3550 Marburg | Polyionische isotonische Salzlösung zur Konservierung von Erythrozyten oder zur Perfusion und zur Konservierung von zur Transplantion bestimmter Organen |
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-
2000
- 2000-07-28 US US09/628,311 patent/US6492103B1/en not_active Expired - Lifetime
-
2001
- 2001-01-24 DE DE60102359T patent/DE60102359T2/de not_active Expired - Lifetime
- 2001-01-24 WO PCT/US2001/002237 patent/WO2001054495A1/en active IP Right Grant
- 2001-01-24 AU AU3109501A patent/AU3109501A/xx active Pending
- 2001-01-24 EP EP01903252A patent/EP1257169B1/de not_active Expired - Lifetime
- 2001-01-24 AU AU2001231095A patent/AU2001231095B2/en not_active Ceased
- 2001-01-24 CA CA002398614A patent/CA2398614A1/en not_active Abandoned
- 2001-01-24 JP JP2001555484A patent/JP2003520859A/ja active Pending
-
2002
- 2002-09-30 US US10/259,771 patent/US6994954B2/en not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
EP1257169B1 (de) | 2004-03-17 |
EP1257169A1 (de) | 2002-11-20 |
CA2398614A1 (en) | 2001-08-02 |
AU3109501A (en) | 2001-08-07 |
DE60102359T2 (de) | 2005-03-10 |
US6994954B2 (en) | 2006-02-07 |
WO2001054495A1 (en) | 2001-08-02 |
US20030118980A1 (en) | 2003-06-26 |
JP2003520859A (ja) | 2003-07-08 |
WO2001054495A9 (en) | 2002-10-24 |
US6492103B1 (en) | 2002-12-10 |
AU2001231095B2 (en) | 2004-07-08 |
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