DE60116758D1 - Einkapselung eines toxischen kerns in einen nicht-toxischen bereich in einer oralen darreichungsform - Google Patents

Einkapselung eines toxischen kerns in einen nicht-toxischen bereich in einer oralen darreichungsform

Info

Publication number
DE60116758D1
DE60116758D1 DE60116758T DE60116758T DE60116758D1 DE 60116758 D1 DE60116758 D1 DE 60116758D1 DE 60116758 T DE60116758 T DE 60116758T DE 60116758 T DE60116758 T DE 60116758T DE 60116758 D1 DE60116758 D1 DE 60116758D1
Authority
DE
Germany
Prior art keywords
toxic
drug
region
potent
dosage form
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60116758T
Other languages
English (en)
Other versions
DE60116758T2 (de
Inventor
C Payumo
Chen-Chao Wang
K Sherwood
J Cima
M Gaylo
C Monkhouse
Jaedeok Yoo
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Massachusetts Institute of Technology
Original Assignee
Massachusetts Institute of Technology
Therics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Massachusetts Institute of Technology, Therics Inc filed Critical Massachusetts Institute of Technology
Publication of DE60116758D1 publication Critical patent/DE60116758D1/de
Application granted granted Critical
Publication of DE60116758T2 publication Critical patent/DE60116758T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2893—Tablet coating processes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/14—Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B33—ADDITIVE MANUFACTURING TECHNOLOGY
    • B33Y—ADDITIVE MANUFACTURING, i.e. MANUFACTURING OF THREE-DIMENSIONAL [3-D] OBJECTS BY ADDITIVE DEPOSITION, ADDITIVE AGGLOMERATION OR ADDITIVE LAYERING, e.g. BY 3-D PRINTING, STEREOLITHOGRAPHY OR SELECTIVE LASER SINTERING
    • B33Y10/00—Processes of additive manufacturing
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B33—ADDITIVE MANUFACTURING TECHNOLOGY
    • B33Y—ADDITIVE MANUFACTURING, i.e. MANUFACTURING OF THREE-DIMENSIONAL [3-D] OBJECTS BY ADDITIVE DEPOSITION, ADDITIVE AGGLOMERATION OR ADDITIVE LAYERING, e.g. BY 3-D PRINTING, STEREOLITHOGRAPHY OR SELECTIVE LASER SINTERING
    • B33Y70/00—Materials specially adapted for additive manufacturing
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B33—ADDITIVE MANUFACTURING TECHNOLOGY
    • B33Y—ADDITIVE MANUFACTURING, i.e. MANUFACTURING OF THREE-DIMENSIONAL [3-D] OBJECTS BY ADDITIVE DEPOSITION, ADDITIVE AGGLOMERATION OR ADDITIVE LAYERING, e.g. BY 3-D PRINTING, STEREOLITHOGRAPHY OR SELECTIVE LASER SINTERING
    • B33Y80/00—Products made by additive manufacturing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2086—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat
    • A61K9/209—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat containing drug in at least two layers or in the core and in at least one outer layer
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2886—Dragees; Coated pills or tablets, e.g. with film or compression coating having two or more different drug-free coatings; Tablets of the type inert core-drug layer-inactive layer
DE60116758T 2000-05-18 2001-05-18 Einkapselung eines toxischen kerns in einen nicht-toxischen bereich in einer oralen darreichungsform Expired - Lifetime DE60116758T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US20589600P 2000-05-18 2000-05-18
US205896P 2000-05-18
PCT/US2001/040763 WO2001087272A2 (en) 2000-05-18 2001-05-18 Encapsulating a toxic core within a non-toxic region in an oral dosage form

Publications (2)

Publication Number Publication Date
DE60116758D1 true DE60116758D1 (de) 2006-04-06
DE60116758T2 DE60116758T2 (de) 2006-11-02

Family

ID=22764098

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60116758T Expired - Lifetime DE60116758T2 (de) 2000-05-18 2001-05-18 Einkapselung eines toxischen kerns in einen nicht-toxischen bereich in einer oralen darreichungsform

Country Status (9)

Country Link
US (2) US7276252B2 (de)
EP (1) EP1286663B1 (de)
JP (2) JP5178982B2 (de)
AT (1) ATE315930T1 (de)
AU (1) AU2001263506A1 (de)
CA (1) CA2408956C (de)
DE (1) DE60116758T2 (de)
ES (1) ES2257412T3 (de)
WO (1) WO2001087272A2 (de)

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Also Published As

Publication number Publication date
ATE315930T1 (de) 2006-02-15
CA2408956C (en) 2011-07-12
JP2012082224A (ja) 2012-04-26
US20020015728A1 (en) 2002-02-07
DE60116758T2 (de) 2006-11-02
EP1286663A2 (de) 2003-03-05
WO2001087272A2 (en) 2001-11-22
EP1286663B1 (de) 2006-01-18
JP5178982B2 (ja) 2013-04-10
US20060110443A1 (en) 2006-05-25
US7276252B2 (en) 2007-10-02
CA2408956A1 (en) 2001-11-22
AU2001263506A1 (en) 2001-11-26
ES2257412T3 (es) 2006-08-01
US7875290B2 (en) 2011-01-25
JP2003533470A (ja) 2003-11-11
WO2001087272A3 (en) 2002-04-18

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Owner name: MASSACHUSETTS INSTITUTE OF TECHNOLOGY, CAMBRID, US