DE60116758D1 - Einkapselung eines toxischen kerns in einen nicht-toxischen bereich in einer oralen darreichungsform - Google Patents

Einkapselung eines toxischen kerns in einen nicht-toxischen bereich in einer oralen darreichungsform

Info

Publication number
DE60116758D1
DE60116758D1 DE60116758T DE60116758T DE60116758D1 DE 60116758 D1 DE60116758 D1 DE 60116758D1 DE 60116758 T DE60116758 T DE 60116758T DE 60116758 T DE60116758 T DE 60116758T DE 60116758 D1 DE60116758 D1 DE 60116758D1
Authority
DE
Germany
Prior art keywords
toxic
drug
region
potent
dosage form
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60116758T
Other languages
English (en)
Other versions
DE60116758T2 (de
Inventor
C Payumo
Chen-Chao Wang
K Sherwood
J Cima
M Gaylo
C Monkhouse
Jaedeok Yoo
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Massachusetts Institute of Technology
Original Assignee
Massachusetts Institute of Technology
Therics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Massachusetts Institute of Technology, Therics Inc filed Critical Massachusetts Institute of Technology
Application granted granted Critical
Publication of DE60116758D1 publication Critical patent/DE60116758D1/de
Publication of DE60116758T2 publication Critical patent/DE60116758T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2893—Tablet coating processes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/14—Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B33—ADDITIVE MANUFACTURING TECHNOLOGY
    • B33Y—ADDITIVE MANUFACTURING, i.e. MANUFACTURING OF THREE-DIMENSIONAL [3-D] OBJECTS BY ADDITIVE DEPOSITION, ADDITIVE AGGLOMERATION OR ADDITIVE LAYERING, e.g. BY 3-D PRINTING, STEREOLITHOGRAPHY OR SELECTIVE LASER SINTERING
    • B33Y10/00—Processes of additive manufacturing
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B33—ADDITIVE MANUFACTURING TECHNOLOGY
    • B33Y—ADDITIVE MANUFACTURING, i.e. MANUFACTURING OF THREE-DIMENSIONAL [3-D] OBJECTS BY ADDITIVE DEPOSITION, ADDITIVE AGGLOMERATION OR ADDITIVE LAYERING, e.g. BY 3-D PRINTING, STEREOLITHOGRAPHY OR SELECTIVE LASER SINTERING
    • B33Y70/00—Materials specially adapted for additive manufacturing
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B33—ADDITIVE MANUFACTURING TECHNOLOGY
    • B33Y—ADDITIVE MANUFACTURING, i.e. MANUFACTURING OF THREE-DIMENSIONAL [3-D] OBJECTS BY ADDITIVE DEPOSITION, ADDITIVE AGGLOMERATION OR ADDITIVE LAYERING, e.g. BY 3-D PRINTING, STEREOLITHOGRAPHY OR SELECTIVE LASER SINTERING
    • B33Y80/00—Products made by additive manufacturing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2086—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat
    • A61K9/209—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat containing drug in at least two layers or in the core and in at least one outer layer
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2886—Dragees; Coated pills or tablets, e.g. with film or compression coating having two or more different drug-free coatings; Tablets of the type inert core-drug layer-inactive layer
DE60116758T 2000-05-18 2001-05-18 Einkapselung eines toxischen kerns in einen nicht-toxischen bereich in einer oralen darreichungsform Expired - Lifetime DE60116758T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US20589600P 2000-05-18 2000-05-18
US205896P 2000-05-18
PCT/US2001/040763 WO2001087272A2 (en) 2000-05-18 2001-05-18 Encapsulating a toxic core within a non-toxic region in an oral dosage form

Publications (2)

Publication Number Publication Date
DE60116758D1 true DE60116758D1 (de) 2006-04-06
DE60116758T2 DE60116758T2 (de) 2006-11-02

Family

ID=22764098

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60116758T Expired - Lifetime DE60116758T2 (de) 2000-05-18 2001-05-18 Einkapselung eines toxischen kerns in einen nicht-toxischen bereich in einer oralen darreichungsform

Country Status (9)

Country Link
US (2) US7276252B2 (de)
EP (1) EP1286663B1 (de)
JP (2) JP5178982B2 (de)
AT (1) ATE315930T1 (de)
AU (1) AU2001263506A1 (de)
CA (1) CA2408956C (de)
DE (1) DE60116758T2 (de)
ES (1) ES2257412T3 (de)
WO (1) WO2001087272A2 (de)

Families Citing this family (84)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030118645A1 (en) * 1998-04-29 2003-06-26 Pather S. Indiran Pharmaceutical compositions for rectal and vaginal administration
US6544555B2 (en) 2000-02-24 2003-04-08 Advancis Pharmaceutical Corp. Antibiotic product, use and formulation thereof
US6565882B2 (en) * 2000-02-24 2003-05-20 Advancis Pharmaceutical Corp Antibiotic composition with inhibitor
US20020068078A1 (en) * 2000-10-13 2002-06-06 Rudnic Edward M. Antifungal product, use and formulation thereof
US6541014B2 (en) * 2000-10-13 2003-04-01 Advancis Pharmaceutical Corp. Antiviral product, use and formulation thereof
US6518330B2 (en) * 2001-02-13 2003-02-11 Board Of Trustees Of University Of Illinois Multifunctional autonomically healing composite material
JP2005509001A (ja) * 2001-10-29 2005-04-07 セリクス， インコーポレイテッド 投薬形態の三次元懸濁液プリンティング
EP1441703B1 (de) 2001-10-29 2018-01-03 Massachusetts Institute of Technology Dosierungsformen mit zero-order freigabe hergestellt durch dreidimensionales drucken
US7931914B2 (en) * 2001-10-29 2011-04-26 Massachusetts Institute Of Technology System and method for uniaxial compression of an article, such as a three-dimensionally printed dosage form
AU2003232078A1 (en) 2002-05-06 2003-11-17 Massachusetts Institute Of Technology Diffusion-controlled dosage form and method of fabrication including three dimensional printing
JP2006528189A (ja) * 2003-07-21 2006-12-14 アドバンシス ファーマスーティカル コーポレイション 抗生物質産物、その使用法および製剤
WO2005009364A2 (en) * 2003-07-21 2005-02-03 Advancis Pharmaceutical Corporation Antibiotic product, use and formulation thereof
WO2005009368A2 (en) 2003-07-21 2005-02-03 Advancis Pharmaceutical Corporation Antibiotic product, use and formulation thereof
EP1653925A1 (de) * 2003-08-11 2006-05-10 Advancis Pharmaceutical Corporation Robustes pellet
CA2535398C (en) 2003-08-12 2013-11-12 Advancis Pharmaceuticals Corporation Antibiotic product, use and formulation thereof
US8246996B2 (en) * 2003-08-29 2012-08-21 Shionogi Inc. Antibiotic product, use and formulation thereof
CA2538064C (en) * 2003-09-15 2013-12-17 Advancis Pharmaceutical Corporation Antibiotic product, use and formulation thereof
US20050087902A1 (en) * 2003-10-28 2005-04-28 Isaac Farr Alginate-based materials, methods of application thereof, and systems for using the alginate-based materials
AU2004308419B2 (en) * 2003-12-24 2011-06-02 Victory Pharma, Inc. Enhanced absorption of modified release dosage forms
US7566747B2 (en) * 2004-05-07 2009-07-28 The Board Of Trustees Of The University Of Illinois Wax particles for protection of activators, and multifunctional autonomically healing composite materials
TWI356036B (en) * 2004-06-09 2012-01-11 Smithkline Beecham Corp Apparatus and method for pharmaceutical production
US20060002594A1 (en) * 2004-06-09 2006-01-05 Clarke Allan J Method for producing a pharmaceutical product
JPWO2006004069A1 (ja) * 2004-07-01 2008-04-24 日本碍子株式会社 微小カプセルおよびその製造方法
WO2006014427A1 (en) * 2004-07-02 2006-02-09 Advancis Pharmaceutical Corporation Tablet for pulsed delivery
WO2006058247A2 (en) * 2004-11-26 2006-06-01 Aprecia Pharmaceuticals Co. Dosage forms and methods of use thereof
US7829000B2 (en) * 2005-02-25 2010-11-09 Hewlett-Packard Development Company, L.P. Core-shell solid freeform fabrication
US7612152B2 (en) * 2005-05-06 2009-11-03 The Board Of Trustees Of The University Of Illinois Self-healing polymers
US7914776B2 (en) * 2005-10-07 2011-03-29 Adolor Corporation Solid dispersions of opioid antagonists
US8357394B2 (en) 2005-12-08 2013-01-22 Shionogi Inc. Compositions and methods for improved efficacy of penicillin-type antibiotics
US8778924B2 (en) * 2006-12-04 2014-07-15 Shionogi Inc. Modified release amoxicillin products
US7723405B2 (en) * 2006-01-05 2010-05-25 The Board Of Trustees Of The University Of Illinois Self-healing coating system
GB0608402D0 (en) * 2006-04-28 2006-06-07 Diurnal Ltd Thyroid treatment
US8299052B2 (en) 2006-05-05 2012-10-30 Shionogi Inc. Pharmaceutical compositions and methods for improved bacterial eradication
US7569625B2 (en) * 2006-06-02 2009-08-04 The Board Of Trustees Of The University Of Illinois Self-healing elastomer system
DE602007006492D1 (de) 2006-07-25 2010-06-24 Lipoxen Technologies Ltd Derivatisierung des granulozytenkoloniestimulierenden faktors
US20080107725A1 (en) * 2006-10-13 2008-05-08 Albano Antonio A Pharmaceutical Solid Dosage Forms Comprising Amorphous Compounds Micro-Embedded in Ionic Water-Insoluble Polymers
US20080299391A1 (en) * 2007-05-31 2008-12-04 White Scott R Capsules, methods for making capsules, and self-healing composites including the same
WO2009007969A2 (en) * 2007-07-09 2009-01-15 Colint Ltd. Portable hydration apparatus
US20090181254A1 (en) * 2008-01-15 2009-07-16 The Board Of Trustees Of The University Of Illinois Multi-capsule system and its use for encapsulating active agents
JP2011074015A (ja) * 2009-09-30 2011-04-14 Tomita Pharmaceutical Co Ltd 固形製剤及びその製造方法
DE102010051743B4 (de) 2010-11-19 2022-09-01 C. Miethke Gmbh & Co. Kg Programmierbares Hydrocephalusventil
KR101869127B1 (ko) * 2011-05-25 2018-06-19 다이호야쿠힌고교 가부시키가이샤 테가푸르, 기메라실 및 오테라실칼륨 함유 구강내 붕괴정
US9381154B2 (en) * 2011-06-09 2016-07-05 Xerox Corporation Direct inkjet fabrication of drug delivery devices
US8414654B1 (en) * 2011-11-23 2013-04-09 Amendia, Inc. Bone implants and method of manufacture
CN102551927A (zh) * 2011-11-29 2012-07-11 上海大学 嵌入式分级释药三维支架及其制备方法
US8888480B2 (en) 2012-09-05 2014-11-18 Aprecia Pharmaceuticals Company Three-dimensional printing system and equipment assembly
IN2015DN01776A (de) 2012-09-05 2015-05-29 Aprecia Pharmaceuticals Co
US20140099351A1 (en) * 2012-10-04 2014-04-10 Axxia Pharmaceuticals, Llc Process for making controlled release medical implant products
US9339489B2 (en) 2013-03-15 2016-05-17 Aprecia Pharmaceuticals Company Rapid disperse dosage form containing levetiracetam
CA2906172C (en) 2013-03-15 2021-12-21 Aprecia Pharmaceuticals Company Rapidly dispersible dosage form of topiramate
CN109908355B (zh) 2013-03-15 2022-11-15 阿普雷奇亚制药有限责任公司 包含左乙拉西坦的快速分散剂型
ES2761265T3 (es) * 2013-03-15 2020-05-19 Aprecia Pharmaceuticals LLC Forma de dosificación de oxcarbazepina rápidamente dispersable
US10471497B2 (en) 2013-08-16 2019-11-12 The Exone Company Three-dimensional printed metal-casting molds and methods for making the same
EP3057729A4 (de) 2013-10-17 2017-10-18 The Exone Company Isostatische heisspressbehälter mit 3d-druck und verfahren zur herstellung davon
WO2015100084A1 (en) 2013-12-23 2015-07-02 The Exone Company Method of three-dimensional printing using a multi-component build powder
ES2745763T3 (es) 2013-12-23 2020-03-03 The Exone Co Métodos y sistemas para la impresión en tres dimensiones utilizando múltiples fluidos aglutinantes
WO2015130963A2 (en) 2014-02-27 2015-09-03 Xenetic Biosciences, Inc. Compositions and methods for administering insulin or insulin-like protein to the brain
EP3148730A1 (de) 2014-05-29 2017-04-05 The Exone Company Verfahren zur herstellung von superlegierungsartikeln auf nickelbasis durch dreidimensionales drucken
US20170203514A1 (en) 2014-07-17 2017-07-20 The Exone Company Methods and Apparatuses for Curing Three-Dimensional Printed Articles
US9854828B2 (en) 2014-09-29 2018-01-02 William Langeland Method, system and apparatus for creating 3D-printed edible objects
ES2832588T3 (es) 2014-12-03 2021-06-10 The Exone Co Proceso para fabricar artículos de carbono densificados mediante impresión tridimensional
WO2016192680A1 (en) 2015-06-03 2016-12-08 Triastek, Inc. Dosage forms and use thereof
RU2018109736A (ru) 2015-08-21 2019-09-23 АПРЕЦИЯ ФАРМАСЬЮТИКАЛЗ ЭлЭлСи Система и аппаратный агрегат трехмерной печати
EP3364946A4 (de) 2015-10-23 2019-06-26 Lyndra, Inc. Magenverweilsysteme zur verzögerten freisetzung von therapeutischen wirkstoffen und verfahren zu deren verwendung
JP6878417B2 (ja) * 2016-02-17 2021-05-26 トリアステック インコーポレイテッド 剤形およびそれらの使用
KR101965283B1 (ko) 2016-05-05 2019-04-03 트리아스텍 인코포레이티드 제어 방출 제형
US10765658B2 (en) 2016-06-22 2020-09-08 Mastix LLC Oral compositions delivering therapeutically effective amounts of cannabinoids
GB201612853D0 (en) 2016-07-25 2016-09-07 Univ Central Lancashire Solid dosage form production
JP2019532947A (ja) 2016-09-30 2019-11-14 リンドラ，インコーポレイティド アダマンタン系薬物の持続的送達のための胃内滞留システム
GB201620066D0 (en) 2016-11-28 2017-01-11 Ucl Business Plc Solid Pharmaceutical dosage formulations and processes
WO2018156141A1 (en) 2017-02-24 2018-08-30 Hewlett-Packard Development Company, L.P. Three-dimensional (3d) printing a pharmaceutical tablet
GR1009361B (el) 2017-05-11 2018-09-17 Κωνσταντινος Ηλια Θεοδοσοπουλος Συστημα παραγωγης μεσω τρισδιαστατης εκτυπωσης, δισκιων, κοκκιων και καψουλων
KR102626745B1 (ko) 2017-05-26 2024-01-17 인피니트 머티리얼 솔루션즈, 엘엘씨 수용성 중합체 조성물
US10350822B1 (en) 2018-01-09 2019-07-16 Triastek Inc. Dosage forms with desired release profiles and methods of designing and making thereof
CN116270513A (zh) 2018-01-09 2023-06-23 南京三迭纪医药科技有限公司 一种包含固定剂量adhd非兴奋剂和adhd兴奋剂的复方口服药物剂型
DE102018107585B3 (de) * 2018-03-29 2019-03-28 Universität Rostock Vorrichtung zur Herstellung von 3D-gedruckten Wirkstofffreisetzungssystemen mit Wirkstoffdepots, sowie Verfahren zur Herstellung von 3D-gedruckten Wirkstofffreisetzungssystemen
IT201800004265A1 (it) 2018-04-06 2019-10-06 Apparato e metodo per la produzione automatizzata di forme di dosaggio personalizzabili.
WO2020081561A1 (en) 2018-10-15 2020-04-23 Aprecia Pharmaceuticals LLC Method and system for forming a dosage form within a packaging
CN113557001B (zh) * 2019-01-07 2023-10-20 卢克斯坎创新私人有限责任公司 用于将粉末状、液体状、糊状、包封的或颗粒状活性成分组合物压片的装置
US11724486B2 (en) 2019-07-09 2023-08-15 Kyndryl, Inc. Printing customized medication based on current user data and medical records of the user
GB201913972D0 (en) 2019-09-27 2019-11-13 Univ Ulster Pharmaceutical Delivery Device and method of manufacture
EP4171518A1 (de) 2020-06-26 2023-05-03 Aprecia Pharmaceuticals LLC Schnell im mund dispergierbare tabletten mit einem inneren hohlraum
EP4238556A1 (de) 2020-10-30 2023-09-06 Triastek, Inc. Gastroretentive pharmazeutische darreichungsform
GB2608846A (en) * 2021-07-14 2023-01-18 Quay Pharmaceuticals Ltd Method and apparatus for additive manufacturing

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2801203A (en) * 1951-03-22 1957-07-30 Byk Gulden Lomberg Chem Fab X-ray method of digestive enzyme diagnosis using protected core of contrast agent
US4943579A (en) * 1987-10-06 1990-07-24 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Water soluble prodrugs of camptothecin
US5082669A (en) 1989-07-20 1992-01-21 Dainippon Pharmaceutical Co., Ltd. Rapid-releasing oral particle pharmaceutical preparation with unpleasant taste masked
US5215989A (en) 1989-12-08 1993-06-01 Merck & Co., Inc. Nitrogen-containing heterocyclic compounds as class III antiarrhythmic agents
US5314696A (en) * 1991-06-27 1994-05-24 Paulos Manley A Methods for making and administering a blinded oral dosage form and blinded oral dosage form therefor
WO1994009762A1 (en) 1992-11-05 1994-05-11 Merck & Co., Inc. Drug delivery device
US6280771B1 (en) * 1997-02-20 2001-08-28 Therics, Inc. Dosage forms exhibiting multi-phasic release kinetics and methods of manufacture thereof
ZA949929B (en) * 1993-12-23 1995-08-23 Akzo Nobel Nv Sugar-coated pharmaceutical dosage unit.
JPH07223970A (ja) 1994-02-10 1995-08-22 Tanabe Seiyaku Co Ltd 消化管内適所放出製剤
ES2188657T3 (es) * 1994-04-22 2003-07-01 Yamanouchi Pharma Co Ltd Sistema para la liberacion especifica en el colon de un farmaco.
US5597829A (en) * 1994-05-09 1997-01-28 Bionumerik Pharmaceuticals, Inc. Lactone stable formulation of camptothecin and methods for uses thereof
US5783212A (en) * 1996-02-02 1998-07-21 Temple University--of the Commonwealth System of Higher Education Controlled release drug delivery system
WO1998036739A1 (en) * 1997-02-20 1998-08-27 Therics, Inc. Dosage forms exhibiting multiphasic release kinetics and methods of manufacture thereof
US6046177A (en) * 1997-05-05 2000-04-04 Cydex, Inc. Sulfoalkyl ether cyclodextrin based controlled release solid pharmaceutical formulations
US6294199B1 (en) * 1999-04-13 2001-09-25 Beecham Pharmaceuticals (Pte) Limited Method of treating a bacterial infection comprising administering amoxycillin

Also Published As

Publication number Publication date
EP1286663B1 (de) 2006-01-18
US7276252B2 (en) 2007-10-02
WO2001087272A3 (en) 2002-04-18
DE60116758T2 (de) 2006-11-02
WO2001087272A2 (en) 2001-11-22
ES2257412T3 (es) 2006-08-01
JP2012082224A (ja) 2012-04-26
US20060110443A1 (en) 2006-05-25
US7875290B2 (en) 2011-01-25
EP1286663A2 (de) 2003-03-05
JP2003533470A (ja) 2003-11-11
JP5178982B2 (ja) 2013-04-10
CA2408956A1 (en) 2001-11-22
ATE315930T1 (de) 2006-02-15
US20020015728A1 (en) 2002-02-07
CA2408956C (en) 2011-07-12
AU2001263506A1 (en) 2001-11-26

Similar Documents

Publication Publication Date Title
DE60116758D1 (de) Einkapselung eines toxischen kerns in einen nicht-toxischen bereich in einer oralen darreichungsform
KR870000068A (ko) 경구용 약제 조성물
TR200100144T2 (tr) Farmasötik aerosol formülasyonu
NO332857B1 (no) Inhalasjonskapsel samt anvendelse av slike
DE69936730D1 (de) Pharmazeutische aerosolzubereitung, die hfa227 und hfa 134a enthält
JP2007513152A (ja) 耐湿性容器内のチオトロピウムから構成される医薬製品
TNSN06277A1 (en) Pharmaceutical formulations for dry powder inhalers comprising a low-dosage strength active ingredient
ES2195342T3 (es) Formulacion farmaceutica de omeprazol.
AR018891A1 (es) Inhaladores presurizados de dosificacion medida y formulaciones farmaceuticas en aerosol
UY26232A1 (es) Sistemas y métodos para aerosolizar formulaciones farmaceuticas bajo ley 17.164
GB9410222D0 (en) Medicaments
ES2196382T3 (es) Administracion y envase de medicamentos.
MA26892A1 (fr) Formulations pharmaceutiques sous forme de comprimes pour inhalateurs a parer
ATE271383T1 (de) Pulverformulierung zur inhalation
TR200502522T2 (tr) Çözünmez bir aktif madde içeren farmasötik formülasyon
JP2014509313A5 (de)
WO2006008517A3 (en) Use of dry powder compositions for pulmonary delivery
DK1207756T3 (da) Anvendelse af spinosad eller en formulering, der omfatter spinosad
RU2006146870A (ru) Минимизация удержания порошка на поверхностях
DE60313296D1 (de) Pharmazeutische darreichungsformen, welche einen tablettenkern mit einer bruchfestigkeit unter 38n/qcm und einen überzug zum schutz des weichen kerns enthalten
GR900100280A (el) Αντιμυκητικα μεσα αζωλης υπο μορφην αεροζολ.
MX2009000849A (es) Formas de dosificacion liofilizadasdisolvibles oralmente/desintegrables que contienen particulas protegidas.
ES2185452A1 (es) Composicion farmaceutica de fluoxetina en comprimido dispersable recubierto y su proceso de fabricacion.
HUT57203A (en) Process for substituted benzimidazol and paharmaceutical composition containing them
BRPI0607990A2 (pt) formulação de um aerossol farmacêutico para inaladores dosimetrados pressurizados contendo um agente seqüestrante, uso do agente sequestrante, inalador de dosimetrado pressurizado e método de preenchimento do inalador de aerossol

Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8327 Change in the person/name/address of the patent owner

Owner name: MASSACHUSETTS INSTITUTE OF TECHNOLOGY, CAMBRID, US