DE60119556D1 - Optischer sensor zur in-situ messung von analyten - Google Patents

Optischer sensor zur in-situ messung von analyten

Info

Publication number
DE60119556D1
DE60119556D1 DE60119556T DE60119556T DE60119556D1 DE 60119556 D1 DE60119556 D1 DE 60119556D1 DE 60119556 T DE60119556 T DE 60119556T DE 60119556 T DE60119556 T DE 60119556T DE 60119556 D1 DE60119556 D1 DE 60119556D1
Authority
DE
Germany
Prior art keywords
sensor
skin
analytes
optical sensor
situ measurement
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60119556T
Other languages
English (en)
Other versions
DE60119556T2 (de
Inventor
Bo Petersson
Anders Weber
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Precisense AS
Original Assignee
Precisense AS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Precisense AS filed Critical Precisense AS
Application granted granted Critical
Publication of DE60119556D1 publication Critical patent/DE60119556D1/de
Publication of DE60119556T2 publication Critical patent/DE60119556T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/145Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
    • A61B5/14532Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue for measuring glucose, e.g. by tissue impedance measurement
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/145Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
    • A61B5/1455Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using optical sensors, e.g. spectral photometrical oximeters
    • A61B5/1459Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using optical sensors, e.g. spectral photometrical oximeters invasive, e.g. introduced into the body by a catheter
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/68Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient
    • A61B5/6846Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be brought in contact with an internal body part, i.e. invasive
    • A61B5/6847Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be brought in contact with an internal body part, i.e. invasive mounted on an invasive device
    • A61B5/685Microneedles
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54366Apparatus specially adapted for solid-phase testing
    • G01N33/54373Apparatus specially adapted for solid-phase testing involving physiochemical end-point determination, e.g. wave-guides, FETS, gratings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A61M2037/0023Drug applicators using microneedles
DE60119556T 2000-10-13 2001-10-12 Optischer sensor zur in-situ messung von analyten Expired - Lifetime DE60119556T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB0025147 2000-10-13
GBGB0025147.0A GB0025147D0 (en) 2000-10-13 2000-10-13 Optical sensor for in situ measurement of analytes
PCT/EP2001/011822 WO2002030275A1 (en) 2000-10-13 2001-10-12 Optical sensor for in situ measurement of analytes

Publications (2)

Publication Number Publication Date
DE60119556D1 true DE60119556D1 (de) 2006-06-14
DE60119556T2 DE60119556T2 (de) 2007-01-25

Family

ID=9901242

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60119556T Expired - Lifetime DE60119556T2 (de) 2000-10-13 2001-10-12 Optischer sensor zur in-situ messung von analyten

Country Status (15)

Country Link
US (1) US6671527B2 (de)
EP (1) EP1324691B1 (de)
JP (1) JP3873023B2 (de)
AT (1) ATE325575T1 (de)
AU (2) AU1401602A (de)
CA (1) CA2425337C (de)
CY (1) CY1105129T1 (de)
DE (1) DE60119556T2 (de)
DK (1) DK1324691T3 (de)
ES (1) ES2263671T3 (de)
GB (1) GB0025147D0 (de)
NO (1) NO334509B1 (de)
NZ (1) NZ525567A (de)
PT (1) PT1324691E (de)
WO (1) WO2002030275A1 (de)

Families Citing this family (135)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6036924A (en) 1997-12-04 2000-03-14 Hewlett-Packard Company Cassette of lancet cartridges for sampling blood
US6391005B1 (en) 1998-03-30 2002-05-21 Agilent Technologies, Inc. Apparatus and method for penetration with shaft having a sensor for sensing penetration depth
JP4689825B2 (ja) 1998-08-26 2011-05-25 センサーズ・フォー・メデセン・アンド・サイエンス・インコーポレーテッド 光学式検知装置
US7553280B2 (en) 2000-06-29 2009-06-30 Sensors For Medicine And Science, Inc. Implanted sensor processing system and method
US8641644B2 (en) 2000-11-21 2014-02-04 Sanofi-Aventis Deutschland Gmbh Blood testing apparatus having a rotatable cartridge with multiple lancing elements and testing means
TWI252311B (en) * 2001-05-04 2006-04-01 Sensors For Med & Science Inc Electro-optical sensing device with reference channel
CA2448902C (en) 2001-06-12 2010-09-07 Pelikan Technologies, Inc. Self optimizing lancing device with adaptation means to temporal variations in cutaneous properties
US7981056B2 (en) 2002-04-19 2011-07-19 Pelikan Technologies, Inc. Methods and apparatus for lancet actuation
ES2352998T3 (es) 2001-06-12 2011-02-24 Pelikan Technologies Inc. Accionador eléctrico de lanceta.
US8337419B2 (en) 2002-04-19 2012-12-25 Sanofi-Aventis Deutschland Gmbh Tissue penetration device
AU2002344825A1 (en) 2001-06-12 2002-12-23 Pelikan Technologies, Inc. Method and apparatus for improving success rate of blood yield from a fingerstick
US9795747B2 (en) 2010-06-02 2017-10-24 Sanofi-Aventis Deutschland Gmbh Methods and apparatus for lancet actuation
CA2448905C (en) 2001-06-12 2010-09-07 Pelikan Technologies, Inc. Blood sampling apparatus and method
WO2002100254A2 (en) 2001-06-12 2002-12-19 Pelikan Technologies, Inc. Method and apparatus for lancet launching device integrated onto a blood-sampling cartridge
US7025774B2 (en) 2001-06-12 2006-04-11 Pelikan Technologies, Inc. Tissue penetration device
US9427532B2 (en) 2001-06-12 2016-08-30 Sanofi-Aventis Deutschland Gmbh Tissue penetration device
US9226699B2 (en) 2002-04-19 2016-01-05 Sanofi-Aventis Deutschland Gmbh Body fluid sampling module with a continuous compression tissue interface surface
AU2002337788A1 (en) * 2001-09-28 2003-04-07 Biovalve Technologies, Inc. Microneedle with membrane
GB0204640D0 (en) 2002-02-27 2002-04-10 Torsana Diabetes Diagnostics A Injection apparatus
US7547287B2 (en) 2002-04-19 2009-06-16 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US7892183B2 (en) 2002-04-19 2011-02-22 Pelikan Technologies, Inc. Method and apparatus for body fluid sampling and analyte sensing
US7175642B2 (en) 2002-04-19 2007-02-13 Pelikan Technologies, Inc. Methods and apparatus for lancet actuation
US7909778B2 (en) 2002-04-19 2011-03-22 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US7713214B2 (en) 2002-04-19 2010-05-11 Pelikan Technologies, Inc. Method and apparatus for a multi-use body fluid sampling device with optical analyte sensing
US7674232B2 (en) 2002-04-19 2010-03-09 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US8579831B2 (en) 2002-04-19 2013-11-12 Sanofi-Aventis Deutschland Gmbh Method and apparatus for penetrating tissue
US7648468B2 (en) 2002-04-19 2010-01-19 Pelikon Technologies, Inc. Method and apparatus for penetrating tissue
US7291117B2 (en) 2002-04-19 2007-11-06 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US8267870B2 (en) 2002-04-19 2012-09-18 Sanofi-Aventis Deutschland Gmbh Method and apparatus for body fluid sampling with hybrid actuation
US8360992B2 (en) 2002-04-19 2013-01-29 Sanofi-Aventis Deutschland Gmbh Method and apparatus for penetrating tissue
US9795334B2 (en) 2002-04-19 2017-10-24 Sanofi-Aventis Deutschland Gmbh Method and apparatus for penetrating tissue
US7976476B2 (en) 2002-04-19 2011-07-12 Pelikan Technologies, Inc. Device and method for variable speed lancet
US8372016B2 (en) 2002-04-19 2013-02-12 Sanofi-Aventis Deutschland Gmbh Method and apparatus for body fluid sampling and analyte sensing
US7331931B2 (en) 2002-04-19 2008-02-19 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US9314194B2 (en) 2002-04-19 2016-04-19 Sanofi-Aventis Deutschland Gmbh Tissue penetration device
US7229458B2 (en) 2002-04-19 2007-06-12 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US9248267B2 (en) 2002-04-19 2016-02-02 Sanofi-Aventis Deustchland Gmbh Tissue penetration device
US7491178B2 (en) 2002-04-19 2009-02-17 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US7901362B2 (en) 2002-04-19 2011-03-08 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US7371247B2 (en) 2002-04-19 2008-05-13 Pelikan Technologies, Inc Method and apparatus for penetrating tissue
US7232451B2 (en) 2002-04-19 2007-06-19 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US7717863B2 (en) 2002-04-19 2010-05-18 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US8221334B2 (en) 2002-04-19 2012-07-17 Sanofi-Aventis Deutschland Gmbh Method and apparatus for penetrating tissue
US8702624B2 (en) 2006-09-29 2014-04-22 Sanofi-Aventis Deutschland Gmbh Analyte measurement device with a single shot actuator
US8784335B2 (en) 2002-04-19 2014-07-22 Sanofi-Aventis Deutschland Gmbh Body fluid sampling device with a capacitive sensor
US7297122B2 (en) 2002-04-19 2007-11-20 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
AU2003301064A1 (en) * 2002-12-17 2004-07-14 Massachusetts Institute Of Technology Stimuli-responsive systems for controlled drug delivery
US8574895B2 (en) 2002-12-30 2013-11-05 Sanofi-Aventis Deutschland Gmbh Method and apparatus using optical techniques to measure analyte levels
CN101907569A (zh) * 2003-04-15 2010-12-08 医药及科学传感器公司 削弱光学传感器上环境光影响的系统和方法
US7473548B2 (en) 2003-04-25 2009-01-06 Medtronic, Inc. Optical detector for enzyme activation
EP2238892A3 (de) 2003-05-30 2011-02-09 Pelikan Technologies Inc. Vorrichtung zur Entnahme von Körperflüssigkeit
US7850621B2 (en) 2003-06-06 2010-12-14 Pelikan Technologies, Inc. Method and apparatus for body fluid sampling and analyte sensing
WO2006001797A1 (en) 2004-06-14 2006-01-05 Pelikan Technologies, Inc. Low pain penetrating
US7632234B2 (en) * 2003-08-29 2009-12-15 Medtronic, Inc. Implantable biosensor devices for monitoring cardiac marker molecules
WO2005033659A2 (en) 2003-09-29 2005-04-14 Pelikan Technologies, Inc. Method and apparatus for an improved sample capture device
WO2005037095A1 (en) 2003-10-14 2005-04-28 Pelikan Technologies, Inc. Method and apparatus for a variable user interface
US7496392B2 (en) 2003-11-26 2009-02-24 Becton, Dickinson And Company Fiber optic device for sensing analytes
US7787923B2 (en) * 2003-11-26 2010-08-31 Becton, Dickinson And Company Fiber optic device for sensing analytes and method of making same
GB0329161D0 (en) 2003-12-16 2004-01-21 Precisense As Reagant for detecting an analyte
GB0329849D0 (en) 2003-12-23 2004-01-28 Precisense As Fluorometers
US8668656B2 (en) 2003-12-31 2014-03-11 Sanofi-Aventis Deutschland Gmbh Method and apparatus for improving fluidic flow and sample capture
US7822454B1 (en) 2005-01-03 2010-10-26 Pelikan Technologies, Inc. Fluid sampling device with improved analyte detecting member configuration
GB0411162D0 (en) * 2004-05-19 2004-06-23 Precisense As Optical sensor for in vivo detection of analyte
EP1751546A2 (de) 2004-05-20 2007-02-14 Albatros Technologies GmbH & Co. KG Bedruckbares wassergel für biosensoren
WO2005120365A1 (en) 2004-06-03 2005-12-22 Pelikan Technologies, Inc. Method and apparatus for a fluid sampling device
US9775553B2 (en) 2004-06-03 2017-10-03 Sanofi-Aventis Deutschland Gmbh Method and apparatus for a fluid sampling device
JP5502279B2 (ja) * 2004-10-28 2014-05-28 エコー セラピューティクス, インコーポレイテッド ヒドロゲルを使用した検体のサンプリングおよび分析のためのシステムおよび方法
GB0426822D0 (en) 2004-12-07 2005-01-12 Precisense As Sensor for detection of glucose
GB0426823D0 (en) 2004-12-07 2005-01-12 Precisense As Sensor for detection of glucose
US8652831B2 (en) 2004-12-30 2014-02-18 Sanofi-Aventis Deutschland Gmbh Method and apparatus for analyte measurement test time
DE502005005099D1 (de) * 2005-03-23 2008-10-02 Roche Diagnostics Gmbh Verfahren zur Bestimmung der Glucosekonzentration durch Fluoreszenzpolarisation
US7308292B2 (en) 2005-04-15 2007-12-11 Sensors For Medicine And Science, Inc. Optical-based sensing devices
US7704704B2 (en) * 2005-09-28 2010-04-27 The Texas A&M University System Implantable system for glucose monitoring using fluorescence quenching
US7687608B2 (en) * 2005-10-19 2010-03-30 Smartcells, Inc. Methods for reducing the mitogenicity of lectin compositions
US20070173706A1 (en) * 2005-11-11 2007-07-26 Isense Corporation Method and apparatus for insertion of a sensor
US9615851B2 (en) 2005-11-11 2017-04-11 Waveform Technologies, Inc. Method and apparatus for insertion of a sensor
US9610459B2 (en) 2009-07-24 2017-04-04 Emkinetics, Inc. Cooling systems and methods for conductive coils
US9339641B2 (en) 2006-01-17 2016-05-17 Emkinetics, Inc. Method and apparatus for transdermal stimulation over the palmar and plantar surfaces
US20100202966A1 (en) * 2006-03-28 2010-08-12 Yossi Gross Implantable Sensor
US7809441B2 (en) 2006-05-17 2010-10-05 Cardiac Pacemakers, Inc. Implantable medical device with chemical sensor and related methods
US11224742B2 (en) 2006-10-02 2022-01-18 Emkinetics, Inc. Methods and devices for performing electrical stimulation to treat various conditions
US9005102B2 (en) 2006-10-02 2015-04-14 Emkinetics, Inc. Method and apparatus for electrical stimulation therapy
US10786669B2 (en) 2006-10-02 2020-09-29 Emkinetics, Inc. Method and apparatus for transdermal stimulation over the palmar and plantar surfaces
CA2665134A1 (en) 2006-10-02 2008-04-10 Emkinetics, Inc. Method and apparatus for magnetic induction therapy
US8560059B2 (en) * 2007-03-09 2013-10-15 Covidien Lp System and methods for optical sensing and drug delivery using microneedles
US7713196B2 (en) 2007-03-09 2010-05-11 Nellcor Puritan Bennett Llc Method for evaluating skin hydration and fluid compartmentalization
US20080275318A1 (en) * 2007-04-20 2008-11-06 Becton, Dickinson And Company Biosensors for measuring analytes in the interstitial fluid
GB0716159D0 (en) 2007-08-17 2007-09-26 Precisense As Injection apparatus
US8409140B2 (en) 2007-08-17 2013-04-02 Medtronic Minimed, Inc. Injection apparatus
CN100591388C (zh) * 2008-01-04 2010-02-24 南京大学 一种微针阵列注射器的制备方法
US9386944B2 (en) 2008-04-11 2016-07-12 Sanofi-Aventis Deutschland Gmbh Method and apparatus for analyte detecting device
EP2174586B1 (de) * 2008-10-02 2014-12-10 EyeSense AG Implantierbares Sensorelement
US9375169B2 (en) 2009-01-30 2016-06-28 Sanofi-Aventis Deutschland Gmbh Cam drive for managing disposable penetrating member actions with a single motor and motor and control system
US9517023B2 (en) 2009-06-01 2016-12-13 Profusa, Inc. Method and system for directing a localized biological response to an implant
JP2011001469A (ja) * 2009-06-18 2011-01-06 Terumo Corp 蛍光ハイドロゲルビーズの製造方法
JP5380174B2 (ja) * 2009-06-18 2014-01-08 テルモ株式会社 蛍光ハイドロゲルビーズおよびそれを用いた体内埋め込み用の糖類測定用センサー
AU2010313487A1 (en) 2009-10-26 2012-05-24 Emkinetics, Inc. Method and apparatus for electromagnetic stimulation of nerve, muscle, and body tissues
JP2013519483A (ja) * 2010-02-19 2013-05-30 ライトシップ メディカル リミテッド 皮下グルコースセンサ
US8795595B2 (en) 2010-04-07 2014-08-05 Medtronic Minimed, Inc. Sensor substrate systems and methods
US8965476B2 (en) 2010-04-16 2015-02-24 Sanofi-Aventis Deutschland Gmbh Tissue penetration device
WO2011132355A1 (en) 2010-04-20 2011-10-27 Panasonic Corporation A method for measuring a concentration of a biogenic substance contained in a living body
US10010272B2 (en) 2010-05-27 2018-07-03 Profusa, Inc. Tissue-integrating electronic apparatus
US8588884B2 (en) 2010-05-28 2013-11-19 Emkinetics, Inc. Microneedle electrode
CN101905856B (zh) * 2010-06-11 2012-10-10 北京大学 一种用于透皮给药的平面空心微针的制备方法
CN105147300B (zh) 2010-10-06 2019-09-03 普罗弗萨股份有限公司 组织整合性传感器
JP5002078B2 (ja) 2010-10-06 2012-08-15 パナソニック株式会社 生体に含有される生体成分の濃度を測定する方法
US8509868B2 (en) 2011-04-12 2013-08-13 Panasonic Corporation Method for measuring a concentration of a biogenic substance contained in a living body
US9642568B2 (en) 2011-09-06 2017-05-09 Medtronic Minimed, Inc. Orthogonally redundant sensor systems and methods
US8999720B2 (en) 2011-11-17 2015-04-07 Medtronic Minimed, Inc. Aqueous radiation protecting formulations and methods for making and using them
WO2014115516A1 (ja) 2013-01-25 2014-07-31 パナソニック株式会社 生体内における被検物質の濃度を計測する計測方法、および、計測装置
CN108013881B (zh) 2013-03-14 2021-06-15 普罗菲尤萨股份有限公司 用于校正光学信号的方法和装置
WO2014185067A1 (ja) 2013-05-17 2014-11-20 パナソニックIpマネジメント株式会社 センサ埋込装置およびセンサ埋込システム
EP3777656A1 (de) 2013-06-06 2021-02-17 Profusa, Inc. Vorrichtung und verfahren zur detektion optischer signale aus implantierten sensoren
US10542918B2 (en) 2013-10-23 2020-01-28 Verily Life Sciences Llc Modulation of a response signal to distinguish between analyte and background signals
US9504405B2 (en) 2013-10-23 2016-11-29 Verily Life Sciences Llc Spatial modulation of magnetic particles in vasculature by external magnetic field
US9936905B2 (en) 2013-10-25 2018-04-10 Medtronic Minimed, Inc. Sensor with optical interface
US20170055499A1 (en) * 2014-05-21 2017-03-02 Empire Technology Development Llc Tattoo and tattoo applicator for animal lifecycle monitoring
US9910035B1 (en) 2014-07-16 2018-03-06 Verily Life Sciences Llc Polyvalent functionalized nanoparticle-based in vivo diagnostic system
US9820690B1 (en) 2014-07-16 2017-11-21 Verily Life Sciences Llc Analyte detection system
US9874554B1 (en) 2014-07-16 2018-01-23 Verily Life Sciences Llc Aptamer-based in vivo diagnostic system
WO2016059635A1 (en) 2014-10-13 2016-04-21 Glusense Ltd. Analyte-sensing device
US20160354500A1 (en) 2015-06-02 2016-12-08 Medtronic Minimed, Inc. Protective agents against e-beam irradiation for proteins in optical sensing chemistry
US10716500B2 (en) 2015-06-29 2020-07-21 Cardiac Pacemakers, Inc. Systems and methods for normalization of chemical sensor data based on fluid state changes
WO2017183030A1 (en) 2016-04-20 2017-10-26 Glusense Ltd. Fret-based glucose-detection molecules
WO2018119204A1 (en) 2016-12-21 2018-06-28 Profusa, Inc. Polymerizable near-ir dyes
WO2018119400A1 (en) 2016-12-22 2018-06-28 Profusa, Inc. System and single-channel luminescent sensor for and method of determining analyte value
US10792378B2 (en) 2017-04-28 2020-10-06 Medtronics Minimed, Inc. Using a blue-shifted reference dye in an optical glucose assay
US10543288B2 (en) 2017-04-28 2020-01-28 Medtronic Minimed, Inc. Modified-dextrans for use in optical glucose assays
CN108968976B (zh) 2017-05-31 2022-09-13 心脏起搏器股份公司 具有化学传感器的植入式医疗设备
CN109381195B (zh) 2017-08-10 2023-01-10 心脏起搏器股份公司 包括电解质传感器融合的系统和方法
CN109419515B (zh) 2017-08-23 2023-03-24 心脏起搏器股份公司 具有分级激活的可植入化学传感器
CN109864746B (zh) 2017-12-01 2023-09-29 心脏起搏器股份公司 用于医学装置的多模式分析物传感器
CN109864747B (zh) 2017-12-05 2023-08-25 心脏起搏器股份公司 多模式分析物传感器光电子接口
WO2019142913A1 (ja) * 2018-01-18 2019-07-25 国立大学法人東京大学 3次元組織内のグルコース濃度マッピングのための蛍光マイクロ粒子
CN112294299A (zh) * 2019-08-02 2021-02-02 华广生技股份有限公司 生物传感器的植入装置及其植入方法

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3996345A (en) 1974-08-12 1976-12-07 Syva Company Fluorescence quenching with immunological pairs in immunoassays
DE2655801C2 (de) * 1976-12-09 1986-06-26 Kernforschungsanlage Jülich GmbH, 5170 Jülich Injizierbare Suspension von Membranvesikeln aus Erythrozyten und Verfahren zur Herstellung der Suspension
US4344438A (en) 1978-08-02 1982-08-17 The United States Of America As Represented By The Department Of Health, Education And Welfare Optical sensor of plasma constituents
US4945050A (en) 1984-11-13 1990-07-31 Cornell Research Foundation, Inc. Method for transporting substances into living cells and tissues and apparatus therefor
US5101814A (en) * 1989-08-11 1992-04-07 Palti Yoram Prof System for monitoring and controlling blood glucose
US6040194A (en) * 1989-12-14 2000-03-21 Sensor Technologies, Inc. Methods and device for detecting and quantifying substances in body fluids
US5342789A (en) 1989-12-14 1994-08-30 Sensor Technologies, Inc. Method and device for detecting and quantifying glucose in body fluids
US5149655A (en) 1990-06-21 1992-09-22 Agracetus, Inc. Apparatus for genetic transformation
TW404844B (en) 1993-04-08 2000-09-11 Oxford Biosciences Ltd Needleless syringe
DE69633573T2 (de) 1995-11-22 2005-10-06 Medtronic MiniMed, Inc., Northridge Detektion von biologischen molekülen unter verwendung von chemischer amplifikation und optischem sensor
GB9605690D0 (en) 1996-03-19 1996-05-22 Oxford Biosciences Ltd Particle delivery
US6232130B1 (en) * 1997-06-04 2001-05-15 Sensor Technologies, Inc. Method for detecting or quantifying carbohydrate containing compounds
AU767122B2 (en) 1998-06-10 2003-10-30 Georgia Tech Research Corporation Microneedle devices and methods of manufacture and use thereof
GB9814506D0 (en) 1998-07-03 1998-09-02 Stanley Christopher J Optical sensor for insitu measurement of analytes
CA2352974A1 (en) * 1998-12-18 2000-06-22 John H. Livingston Insertion sets with micro-piercing members for use with medical devices and methods of using the same

Also Published As

Publication number Publication date
US6671527B2 (en) 2003-12-30
CY1105129T1 (el) 2010-03-03
US20020058863A1 (en) 2002-05-16
CA2425337A1 (en) 2002-04-18
WO2002030275A1 (en) 2002-04-18
ES2263671T3 (es) 2006-12-16
DE60119556T2 (de) 2007-01-25
NZ525567A (en) 2004-05-28
EP1324691B1 (de) 2006-05-10
JP3873023B2 (ja) 2007-01-24
AU1401602A (en) 2002-04-22
NO20031685D0 (no) 2003-04-11
GB0025147D0 (en) 2000-11-29
NO334509B1 (no) 2014-03-24
ATE325575T1 (de) 2006-06-15
EP1324691A1 (de) 2003-07-09
DK1324691T3 (da) 2006-09-11
AU2002214016B2 (en) 2005-06-16
NO20031685L (no) 2003-05-28
PT1324691E (pt) 2006-08-31
CA2425337C (en) 2012-01-10
JP2004510527A (ja) 2004-04-08

Similar Documents

Publication Publication Date Title
DE60119556D1 (de) Optischer sensor zur in-situ messung von analyten
GB2365526B (en) Assay apparatus for measuring the amount of an analyte in a biological or environmental sample
DE50013029D1 (de) Probenkammer zur Flüssigkeitsbehandlung biologischer Proben
GB2350421B (en) Apparatus and method of testing a biological fluid
DE69731000D1 (de) Vorrichtung zur messung von blut-parametern
AR012351A1 (es) Un metodo y dispositivos para dividir muestras biologicas liquidas en microvolumenes
ATE442579T1 (de) Verfahren und vorrichtung zur lumineszenzmessung
DE29809758U1 (de) Vorrichtung zur Entnahme von Körperflüssigkeitsproben
ATE343133T1 (de) Optischer sensor zur in situ messung von analyten
DE69727257D1 (de) Vorrichtung zur Messung von Blut-Glukose
WO2001008551A3 (en) Luminous glucose monitoring device
EP1557662A4 (de) Bestimmungsverfahren zum automatischen identifizieren einer analytfl ssigkeit und standardl sung f r einen biosensor
FI20000111A (fi) Menetelmä paperinvalmistusprosessin analysoimiseksi ja sähkökemiallinen anturi nesteen analysoimiseksi
IL143098A0 (en) A method of detecting the presence of an analyte in a biological sample
AU2002312858A1 (en) Device and method for the optical measurement of chemical and/or biological samples
TW200626897A (en) Biological test strip
ATE373829T1 (de) Lipidassay-verfahren und reagenz zur verwendung darin
ATA5052000A (de) Vorrichtung zur aeroben fermentation von biologischen substanzen
AU2001276346A1 (en) Refractometric method for carrying out long-term stable accurate measurement of the concentrations of dissolved substances and miniaturizable device for carrying out said method
DE69942260D1 (de) Vorrichtung zur ermittlung der schmerzempfindlichkeit
EA200100544A1 (ru) Способ экспресс-диагностики физиологического состояния биологического объекта и устройство для его осуществления
PT1043582E (pt) Camada sensora para controlo de difusao
JP2020153966A (ja) 生体試料保持容器及び生体試料保持方法
DE29807636U1 (de) Vorrichtung zur biologischen Aufbereitung organischer Stoffe in Biomasse
DE29721549U1 (de) Vorrichtung zur Zuführung kleiner Flüssigkeitsmengen

Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8328 Change in the person/name/address of the agent

Representative=s name: JUNG, SCHIRDEWAHN, GRUENBERG, SCHNEIDER PATENTANWAELTE

8328 Change in the person/name/address of the agent

Representative=s name: ADVOTEC. PATENT- UND RECHTSANWAELTE, 80538 MUENCHE