DE60121032D1 - Heterocyclische sulfonamide als inhibitoren der beta-amyloid-produktion - Google Patents
Heterocyclische sulfonamide als inhibitoren der beta-amyloid-produktionInfo
- Publication number
- DE60121032D1 DE60121032D1 DE60121032T DE60121032T DE60121032D1 DE 60121032 D1 DE60121032 D1 DE 60121032D1 DE 60121032 T DE60121032 T DE 60121032T DE 60121032 T DE60121032 T DE 60121032T DE 60121032 D1 DE60121032 D1 DE 60121032D1
- Authority
- DE
- Germany
- Prior art keywords
- inhibitors
- beta
- amyloid production
- sulphonamides
- heterocyclic
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D307/56—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D307/64—Sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D333/30—Hetero atoms other than halogen
- C07D333/34—Sulfur atoms
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US25510500P | 2000-12-13 | 2000-12-13 | |
US255105P | 2000-12-13 | ||
PCT/US2001/048375 WO2002057252A2 (en) | 2000-12-13 | 2001-12-11 | Heterocyclic sulfonamide inhibitors of beta amyloid production |
Publications (2)
Publication Number | Publication Date |
---|---|
DE60121032D1 true DE60121032D1 (de) | 2006-08-03 |
DE60121032T2 DE60121032T2 (de) | 2007-01-11 |
Family
ID=22966854
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE60121032T Expired - Lifetime DE60121032T2 (de) | 2000-12-13 | 2001-12-11 | Heterocyclische sulfonamide als inhibitoren der beta-amyloid-produktion |
Country Status (28)
Country | Link |
---|---|
US (5) | US6610734B2 (de) |
EP (1) | EP1341779B1 (de) |
JP (2) | JP2004517892A (de) |
KR (1) | KR100869061B1 (de) |
CN (2) | CN1263750C (de) |
AR (1) | AR035516A1 (de) |
AT (1) | ATE330950T1 (de) |
AU (1) | AU2002245123B2 (de) |
BR (1) | BR0116063A (de) |
CA (1) | CA2436526C (de) |
CY (1) | CY1105441T1 (de) |
DE (1) | DE60121032T2 (de) |
DK (1) | DK1341779T3 (de) |
EA (1) | EA009035B1 (de) |
ES (1) | ES2267853T3 (de) |
HK (1) | HK1059619A1 (de) |
HU (1) | HUP0303857A3 (de) |
IL (3) | IL156268A0 (de) |
MX (1) | MXPA03005255A (de) |
NO (1) | NO328885B1 (de) |
NZ (2) | NZ538100A (de) |
PL (1) | PL365950A1 (de) |
PT (1) | PT1341779E (de) |
SG (1) | SG128491A1 (de) |
SI (1) | SI1341779T1 (de) |
TW (1) | TWI235155B (de) |
WO (1) | WO2002057252A2 (de) |
ZA (1) | ZA200304135B (de) |
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DE60124684T2 (de) * | 2000-03-20 | 2007-09-13 | Merck Sharp & Dohme Ltd., Hoddesdon | Sulfonamido-substituierte verbrückte bicycloalkylderivative |
CN1263750C (zh) | 2000-12-13 | 2006-07-12 | 惠氏 | β淀粉样蛋白产生的杂环磺酰胺类抑制剂 |
US6657070B2 (en) | 2000-12-13 | 2003-12-02 | Wyeth | Production of chirally pure α-amino acids and N-sulfonyl α-amino acids |
PL370859A1 (en) | 2001-12-11 | 2005-05-30 | Wyeth | Process for the synthesis of chirally pure beta-amino-alcohols |
BR0311767A (pt) * | 2002-06-11 | 2005-03-08 | Wyeth Corp | Compostos inibidores de sulfonamida substituìda da produção de beta amilóide, suas composições e usos |
US7109217B2 (en) * | 2002-11-12 | 2006-09-19 | Merck & Co., Inc. | Phenylcarboxamide beta-secretase inhibitors for the treatment of Alzheimer's disease |
KR20060002908A (ko) * | 2003-03-31 | 2006-01-09 | 와이어쓰 | 베타 아밀로이드 생산 억제제인 플루오로- 및트리플루오로알킬-함유 헤테로사이클릭 설폰아미드 및 이의유도체 |
US7932271B2 (en) * | 2003-06-30 | 2011-04-26 | Daiichi Pharmaceutical Co., Ltd. | Heterocyclic methyl sulfone derivative |
CN1910158A (zh) | 2004-01-16 | 2007-02-07 | 惠氏公司 | 含有氮杂环的β淀粉样蛋白生成的杂环磺酰胺抑制剂 |
CA2595173A1 (en) | 2005-01-18 | 2006-07-27 | Elan Pharmaceuticals, Inc. | N-substituted heterocyclic sulfonamides |
ES2400287T3 (es) * | 2005-03-14 | 2013-04-08 | High Point Pharmaceuticals, Llc | Derivados de benzazol, composiciones y procedimientos de uso como inhibidores de beta-secretasa |
TW200800959A (en) * | 2005-06-10 | 2008-01-01 | Wyeth Corp | Piperazine-piperidine antagonists and agonists of the 5-HT1a receptor |
GB0602951D0 (en) * | 2006-02-14 | 2006-03-29 | Novartis Ag | Organic Compounds |
AU2007217966A1 (en) * | 2006-02-17 | 2007-08-30 | Wyeth | Selective N-sulfonylation of 2-amino trifluoroalkyl substituted alcohols |
CA2641013A1 (en) * | 2006-02-17 | 2007-08-30 | Wyeth | Methods for preparing sulfonamide substituted alcohols and intermediates thereof |
MX2008013539A (es) * | 2006-04-21 | 2008-10-29 | Wyeth Corp | Produccion de intermediarios de amino alcohol quiralmente puros, derivados de los mismos, y usos de los mismos. |
US7476762B2 (en) * | 2006-04-21 | 2009-01-13 | Wyeth | Methods for preparing sulfonamide compounds |
US7550629B2 (en) * | 2006-04-21 | 2009-06-23 | Wyeth | Trifluoromethyl-containing phenylsulfonamide beta amyloid inhibitors |
TW200808740A (en) * | 2006-06-09 | 2008-02-16 | Wyeth Corp | Succinate salts of 6-methoxy-8-[4-(1-(5-fluoro)-quinolin-8-yl-piperidin-4-yl)-piperazin-1-yl]-quinoline and crystalline forms thereof |
TW200808741A (en) * | 2006-06-09 | 2008-02-16 | Wyeth Corp | 6-methoxy-8-[4-(1-(5-fluoro)-quinolin-8-yl-piperidin-4-yl)-piperazin-1-yl]-quinoline hydrochloric acid salts |
TW200811144A (en) * | 2006-06-09 | 2008-03-01 | Wyeth Corp | Crystalline forms of 6-methoxy-8-[4-(1-(5-fluoro)-quinolin-8-yl-piperidin-4-yl)-piperazin-1-yl]-quinoline |
WO2008059238A1 (en) * | 2006-11-17 | 2008-05-22 | Astrazeneca Ab | Benzenesulfonamide compounds as edg-1 antagonists useful in the treatment of cancer |
EP2099741A2 (de) * | 2006-11-21 | 2009-09-16 | University Of Virginia Patent Foundation | Hydrindan-analoga mit sphingosin-1-phosphatrezeptoragonistenaktivität |
CL2007003410A1 (es) * | 2006-11-28 | 2008-04-11 | Wyeth Corp | Compuestos derivados de 5-fluoro-8-{4-[4-(6-metoxiquinolin-8-il)piperazin-1-il]piperidin-1-il}quinolina; procedimiento de preparacion; compuestos intermediarios; procedimiento de preparacion; composicion farmaceutica; y uso en el tratamiento de trast |
TW200901974A (en) | 2007-01-16 | 2009-01-16 | Wyeth Corp | Compounds, compositions, and methods of making and using them |
EP2121633A2 (de) | 2007-02-12 | 2009-11-25 | Merck & Co., Inc. | Piperazinderivate zur behandlung von alzheimer-krankheit und verwandten leiden |
PE20090810A1 (es) * | 2007-07-16 | 2009-07-20 | Wyeth Corp | Procesos e intermediarios para la preparacion de compuestos de sulfonamida heterociclica |
CA2693959A1 (en) * | 2007-07-16 | 2009-01-22 | Wyeth | Inhibitors of beta amyloid production |
US20090023903A1 (en) * | 2007-07-16 | 2009-01-22 | Wyeth | Process for the preparation of trifluoroalkyl-phenyl and heterocyclic sulfonamides |
EP2489656A1 (de) | 2007-12-21 | 2012-08-22 | Ligand Pharmaceuticals Inc. | Selektive Androgenrezeptormodulatoren (SARMS) und ihre Verwendung |
WO2009089237A1 (en) * | 2008-01-11 | 2009-07-16 | Wyeth | Compositions containing o-sulfate and o-phosphate containing aryl sulfonamide derivatives useful as beta-amyloid inhibitors |
US8461389B2 (en) | 2008-04-18 | 2013-06-11 | University College Dublin, National University Of Ireland, Dublin | Psycho-pharmaceuticals |
US8163800B2 (en) | 2008-07-28 | 2012-04-24 | Blanchette Rockefeller Neurosciences Institute | PKC-activating compounds for the treatment of neurodegenerative diseases |
SG181643A1 (en) | 2009-12-17 | 2012-07-30 | Merck Patent Gmbh | Inhibitors of sphingosine kinase |
US9802954B2 (en) | 2011-08-24 | 2017-10-31 | Boehringer Ingelheim International Gmbh | Piperidino-dihydrothienopyrimidine sulfoxides and their use for treating COPD and asthma |
TR201802211T4 (tr) | 2013-01-18 | 2018-03-21 | Cardioxyl Pharmaceuticals Inc | Geliştirilmiş terapötik indekse sahip nitroksil vericiler. |
CN104370769B (zh) * | 2013-08-14 | 2017-05-31 | 重庆博腾制药科技股份有限公司 | 一种制备羟基金刚烷甘氨酸衍生物的方法 |
US10441567B2 (en) | 2014-01-17 | 2019-10-15 | Ligand Pharmaceuticals Incorporated | Methods and compositions for modulating hormone levels |
US11046668B2 (en) | 2016-03-11 | 2021-06-29 | Ohio State Innovation Foundation | Small molecule antimicrobials |
DE202022106287U1 (de) | 2022-11-09 | 2022-11-21 | Ahmad Salawi | Eine Methode zur Synthese und biologischen Bewertung von neuen Sulfonamid-Analoga |
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CN1263750C (zh) | 2000-12-13 | 2006-07-12 | 惠氏 | β淀粉样蛋白产生的杂环磺酰胺类抑制剂 |
US6657070B2 (en) | 2000-12-13 | 2003-12-02 | Wyeth | Production of chirally pure α-amino acids and N-sulfonyl α-amino acids |
PL370859A1 (en) | 2001-12-11 | 2005-05-30 | Wyeth | Process for the synthesis of chirally pure beta-amino-alcohols |
JP4615861B2 (ja) | 2001-12-11 | 2011-01-19 | ワイス・エルエルシー | キラル的に純粋なα−アミノ酸およびN−スルホニルα−アミノ酸の生産 |
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-
2001
- 2001-12-11 CN CNB018205186A patent/CN1263750C/zh not_active Expired - Fee Related
- 2001-12-11 SI SI200130604T patent/SI1341779T1/sl unknown
- 2001-12-11 KR KR1020037007928A patent/KR100869061B1/ko not_active IP Right Cessation
- 2001-12-11 BR BR0116063-0A patent/BR0116063A/pt not_active Application Discontinuation
- 2001-12-11 NZ NZ538100A patent/NZ538100A/en unknown
- 2001-12-11 PL PL01365950A patent/PL365950A1/xx not_active IP Right Cessation
- 2001-12-11 AT AT01993277T patent/ATE330950T1/de active
- 2001-12-11 JP JP2002557933A patent/JP2004517892A/ja not_active Withdrawn
- 2001-12-11 PT PT01993277T patent/PT1341779E/pt unknown
- 2001-12-11 IL IL15626801A patent/IL156268A0/xx active IP Right Review Request
- 2001-12-11 EP EP01993277A patent/EP1341779B1/de not_active Expired - Lifetime
- 2001-12-11 WO PCT/US2001/048375 patent/WO2002057252A2/en active Application Filing
- 2001-12-11 CA CA2436526A patent/CA2436526C/en not_active Expired - Fee Related
- 2001-12-11 EA EA200300674A patent/EA009035B1/ru not_active IP Right Cessation
- 2001-12-11 DE DE60121032T patent/DE60121032T2/de not_active Expired - Lifetime
- 2001-12-11 ES ES01993277T patent/ES2267853T3/es not_active Expired - Lifetime
- 2001-12-11 SG SG200503628A patent/SG128491A1/en unknown
- 2001-12-11 CN CNA2005100035919A patent/CN1800176A/zh active Pending
- 2001-12-11 HU HU0303857A patent/HUP0303857A3/hu unknown
- 2001-12-11 US US10/014,304 patent/US6610734B2/en not_active Expired - Fee Related
- 2001-12-11 AU AU2002245123A patent/AU2002245123B2/en not_active Ceased
- 2001-12-11 NZ NZ526213A patent/NZ526213A/en unknown
- 2001-12-11 MX MXPA03005255A patent/MXPA03005255A/es active IP Right Grant
- 2001-12-11 DK DK01993277T patent/DK1341779T3/da active
- 2001-12-12 AR ARP010105782A patent/AR035516A1/es not_active Application Discontinuation
- 2001-12-12 TW TW090130721A patent/TWI235155B/zh active
-
2003
- 2003-05-28 ZA ZA200304135A patent/ZA200304135B/en unknown
- 2003-06-02 IL IL156268A patent/IL156268A/en not_active IP Right Cessation
- 2003-06-05 US US10/455,674 patent/US6878742B2/en not_active Expired - Fee Related
- 2003-06-11 NO NO20032645A patent/NO328885B1/no not_active IP Right Cessation
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2004
- 2004-03-02 HK HK04101538A patent/HK1059619A1/xx not_active IP Right Cessation
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2005
- 2005-03-16 US US11/081,784 patent/US7691884B2/en not_active Expired - Fee Related
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2006
- 2006-09-14 CY CY20061101305T patent/CY1105441T1/el unknown
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2008
- 2008-01-17 IL IL188853A patent/IL188853A0/en unknown
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2009
- 2009-10-09 US US12/576,513 patent/US7842718B2/en not_active Expired - Fee Related
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2010
- 2010-06-24 JP JP2010144307A patent/JP2010265280A/ja not_active Withdrawn
- 2010-10-19 US US12/907,123 patent/US20110034513A1/en not_active Abandoned
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