DE60121032D1 - Heterocyclische sulfonamide als inhibitoren der beta-amyloid-produktion - Google Patents
Heterocyclische sulfonamide als inhibitoren der beta-amyloid-produktionInfo
- Publication number
- DE60121032D1 DE60121032D1 DE60121032T DE60121032T DE60121032D1 DE 60121032 D1 DE60121032 D1 DE 60121032D1 DE 60121032 T DE60121032 T DE 60121032T DE 60121032 T DE60121032 T DE 60121032T DE 60121032 D1 DE60121032 D1 DE 60121032D1
- Authority
- DE
- Germany
- Prior art keywords
- inhibitors
- beta
- amyloid production
- sulphonamides
- heterocyclic
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D307/56—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D307/64—Sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D333/30—Hetero atoms other than halogen
- C07D333/34—Sulfur atoms
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US25510500P | 2000-12-13 | 2000-12-13 | |
US255105P | 2000-12-13 | ||
PCT/US2001/048375 WO2002057252A2 (en) | 2000-12-13 | 2001-12-11 | Heterocyclic sulfonamide inhibitors of beta amyloid production |
Publications (2)
Publication Number | Publication Date |
---|---|
DE60121032D1 true DE60121032D1 (de) | 2006-08-03 |
DE60121032T2 DE60121032T2 (de) | 2007-01-11 |
Family
ID=22966854
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE60121032T Expired - Lifetime DE60121032T2 (de) | 2000-12-13 | 2001-12-11 | Heterocyclische sulfonamide als inhibitoren der beta-amyloid-produktion |
Country Status (28)
Country | Link |
---|---|
US (5) | US6610734B2 (de) |
EP (1) | EP1341779B1 (de) |
JP (2) | JP2004517892A (de) |
KR (1) | KR100869061B1 (de) |
CN (2) | CN1800176A (de) |
AR (1) | AR035516A1 (de) |
AT (1) | ATE330950T1 (de) |
AU (1) | AU2002245123B2 (de) |
BR (1) | BR0116063A (de) |
CA (1) | CA2436526C (de) |
CY (1) | CY1105441T1 (de) |
DE (1) | DE60121032T2 (de) |
DK (1) | DK1341779T3 (de) |
EA (1) | EA009035B1 (de) |
ES (1) | ES2267853T3 (de) |
HK (1) | HK1059619A1 (de) |
HU (1) | HUP0303857A3 (de) |
IL (3) | IL156268A0 (de) |
MX (1) | MXPA03005255A (de) |
NO (1) | NO328885B1 (de) |
NZ (2) | NZ538100A (de) |
PL (1) | PL365950A1 (de) |
PT (1) | PT1341779E (de) |
SG (1) | SG128491A1 (de) |
SI (1) | SI1341779T1 (de) |
TW (1) | TWI235155B (de) |
WO (1) | WO2002057252A2 (de) |
ZA (1) | ZA200304135B (de) |
Families Citing this family (40)
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AU4086101A (en) * | 2000-03-20 | 2001-10-03 | Merck Sharp & Dohme | Sulphonamido-substituted bridged bicycloalkyl derivatives |
US6657070B2 (en) | 2000-12-13 | 2003-12-02 | Wyeth | Production of chirally pure α-amino acids and N-sulfonyl α-amino acids |
ATE330950T1 (de) * | 2000-12-13 | 2006-07-15 | Wyeth Corp | Heterocyclische sulfonamide als inhibitoren der beta-amyloid-produktion |
AU2002359519B2 (en) | 2001-12-11 | 2009-07-16 | Wyeth | Process for the synthesis of chirally pure beta-amino-alcohols |
NZ536665A (en) * | 2002-06-11 | 2006-11-30 | Wyeth Corp | Use of substituted phenylsulfonamide as inhibitors of beta amyloid production |
JP4494212B2 (ja) * | 2002-11-12 | 2010-06-30 | メルク・シャープ・エンド・ドーム・コーポレイション | アルツハイマー病の治療用フェニルカルボキサミドベータセクレターゼ阻害剤 |
JP2006522126A (ja) | 2003-03-31 | 2006-09-28 | ワイス | βアミロイド生産のフルオロ含有およびトリフルオロアルキル含有複素環スルホンアミド阻害物質およびその誘導体 |
PL379466A1 (pl) * | 2003-06-30 | 2006-09-18 | Daiichi Sankyo Company , Limited | Heterocykliczne pochodne metylosulfonu |
WO2005073198A1 (en) * | 2004-01-16 | 2005-08-11 | Wyeth | Heterocyclic sulfonamide inhibitors of beta amyloid production containing an azole |
EP1838701A1 (de) | 2005-01-18 | 2007-10-03 | Elan Pharmaceuticals Inc. | N-substituierte heterocyclische sulfonamide |
CA2600570C (en) * | 2005-03-14 | 2011-12-06 | Transtech Pharma, Inc. | Benzazole derivatives, compositions, and methods of use as .beta.-secretase inhibitors |
TW200800959A (en) * | 2005-06-10 | 2008-01-01 | Wyeth Corp | Piperazine-piperidine antagonists and agonists of the 5-HT1a receptor |
GB0602951D0 (en) * | 2006-02-14 | 2006-03-29 | Novartis Ag | Organic Compounds |
RU2008129797A (ru) * | 2006-02-17 | 2010-03-27 | Вайет (Us) | Способы получения сульфонамид-замещенных спиртов и их промежуточных соединений |
WO2007098030A1 (en) * | 2006-02-17 | 2007-08-30 | Wyeth | Selective n-sulfonylation of 2-amino trifluoroalkyl substituted alcohols |
US7476762B2 (en) * | 2006-04-21 | 2009-01-13 | Wyeth | Methods for preparing sulfonamide compounds |
BRPI0710470A2 (pt) * | 2006-04-21 | 2011-08-16 | Wyeth Corp | métodos para preparar seletivamente um aminoálcool quiral e uma sulfonamida quiral |
US7550629B2 (en) * | 2006-04-21 | 2009-06-23 | Wyeth | Trifluoromethyl-containing phenylsulfonamide beta amyloid inhibitors |
TW200808740A (en) * | 2006-06-09 | 2008-02-16 | Wyeth Corp | Succinate salts of 6-methoxy-8-[4-(1-(5-fluoro)-quinolin-8-yl-piperidin-4-yl)-piperazin-1-yl]-quinoline and crystalline forms thereof |
TW200808741A (en) * | 2006-06-09 | 2008-02-16 | Wyeth Corp | 6-methoxy-8-[4-(1-(5-fluoro)-quinolin-8-yl-piperidin-4-yl)-piperazin-1-yl]-quinoline hydrochloric acid salts |
TW200811144A (en) * | 2006-06-09 | 2008-03-01 | Wyeth Corp | Crystalline forms of 6-methoxy-8-[4-(1-(5-fluoro)-quinolin-8-yl-piperidin-4-yl)-piperazin-1-yl]-quinoline |
WO2008059238A1 (en) * | 2006-11-17 | 2008-05-22 | Astrazeneca Ab | Benzenesulfonamide compounds as edg-1 antagonists useful in the treatment of cancer |
EP2099741A2 (de) * | 2006-11-21 | 2009-09-16 | University Of Virginia Patent Foundation | Hydrindan-analoga mit sphingosin-1-phosphatrezeptoragonistenaktivität |
TW200831096A (en) * | 2006-11-28 | 2008-08-01 | Wyeth Corp | Metabolites of 5-Fluoro-8-{4-[4-(6-methoxyquinolin-8-yl)piperazin-1-yl]piperidin-1-yl} quinoline and methods of preparation and uses thereof |
CL2008000119A1 (es) * | 2007-01-16 | 2008-05-16 | Wyeth Corp | Compuestos derivados de pirazol, antagonistas del receptor nicotinico de acetilcolina; composicion farmaceutica; y uso en el tratamiento de enfermedades tales como demencia senil, alzheimer y esquizofrenia. |
US20100204230A1 (en) | 2007-02-12 | 2010-08-12 | Peter Blurton | Piperazine derivatives for treatment of ad and related conditions |
PA8789601A1 (es) * | 2007-07-16 | 2009-02-09 | Wyeth Corp | Proceso para la preparación de trifluoralquil-fenil sulfonamidas y de sulfonamidas heterocíclicas |
AR067533A1 (es) * | 2007-07-16 | 2009-10-14 | Wyeth Corp | Procesos e inetermediarios para la preparacion de compuestos de sulfonamida heterociclica |
US20090023801A1 (en) * | 2007-07-16 | 2009-01-22 | Wyeth | Inhibitors of beta amyloid production |
CN101945853B (zh) | 2007-12-21 | 2014-08-20 | 配体药物公司 | 选择性雄激素受体调节剂(sarm)及其应用 |
WO2009089237A1 (en) * | 2008-01-11 | 2009-07-16 | Wyeth | Compositions containing o-sulfate and o-phosphate containing aryl sulfonamide derivatives useful as beta-amyloid inhibitors |
EP2291181B9 (de) | 2008-04-18 | 2013-09-11 | University College Dublin National University Of Ireland, Dublin | Captodiamine zur Behandlung von depressionartigen Symptomen |
EP2328572B1 (de) | 2008-07-28 | 2018-06-13 | Blanchette Rockefeller Neurosciences, Institute | Pkc-aktivierende verbindungen zur behandlung von neurodegenerativen erkrankungen |
MX2012006962A (es) | 2009-12-17 | 2012-07-17 | Merck Patent Gmbh | Inhibidores de la esfingosina quinasa. |
US9802954B2 (en) | 2011-08-24 | 2017-10-31 | Boehringer Ingelheim International Gmbh | Piperidino-dihydrothienopyrimidine sulfoxides and their use for treating COPD and asthma |
AU2014207408C1 (en) | 2013-01-18 | 2018-09-06 | Cardioxyl Pharmaceuticals, Inc. | Pharmaceutical compositions comprising nitroxyl donors |
CN104370769B (zh) * | 2013-08-14 | 2017-05-31 | 重庆博腾制药科技股份有限公司 | 一种制备羟基金刚烷甘氨酸衍生物的方法 |
WO2015108988A2 (en) | 2014-01-17 | 2015-07-23 | Ligand Pharmaceuticals, Inc. | Methods and compositions for modulating hormone levels |
WO2017155890A1 (en) * | 2016-03-11 | 2017-09-14 | Ohio State Innovation Foundation | Novel small molecule antimicrobials |
DE202022106287U1 (de) | 2022-11-09 | 2022-11-21 | Ahmad Salawi | Eine Methode zur Synthese und biologischen Bewertung von neuen Sulfonamid-Analoga |
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US6657070B2 (en) * | 2000-12-13 | 2003-12-02 | Wyeth | Production of chirally pure α-amino acids and N-sulfonyl α-amino acids |
ATE330950T1 (de) * | 2000-12-13 | 2006-07-15 | Wyeth Corp | Heterocyclische sulfonamide als inhibitoren der beta-amyloid-produktion |
AU2002359519B2 (en) | 2001-12-11 | 2009-07-16 | Wyeth | Process for the synthesis of chirally pure beta-amino-alcohols |
AU2002351170B8 (en) | 2001-12-11 | 2009-10-08 | Wyeth | Production of chirally pure alpha-amino acids and N-sulfonyl alpha-amino acids |
NZ536665A (en) * | 2002-06-11 | 2006-11-30 | Wyeth Corp | Use of substituted phenylsulfonamide as inhibitors of beta amyloid production |
JP2006522126A (ja) * | 2003-03-31 | 2006-09-28 | ワイス | βアミロイド生産のフルオロ含有およびトリフルオロアルキル含有複素環スルホンアミド阻害物質およびその誘導体 |
-
2001
- 2001-12-11 AT AT01993277T patent/ATE330950T1/de active
- 2001-12-11 ES ES01993277T patent/ES2267853T3/es not_active Expired - Lifetime
- 2001-12-11 JP JP2002557933A patent/JP2004517892A/ja not_active Withdrawn
- 2001-12-11 CA CA2436526A patent/CA2436526C/en not_active Expired - Fee Related
- 2001-12-11 KR KR1020037007928A patent/KR100869061B1/ko not_active IP Right Cessation
- 2001-12-11 PT PT01993277T patent/PT1341779E/pt unknown
- 2001-12-11 CN CNA2005100035919A patent/CN1800176A/zh active Pending
- 2001-12-11 DE DE60121032T patent/DE60121032T2/de not_active Expired - Lifetime
- 2001-12-11 PL PL01365950A patent/PL365950A1/xx not_active IP Right Cessation
- 2001-12-11 BR BR0116063-0A patent/BR0116063A/pt not_active Application Discontinuation
- 2001-12-11 EP EP01993277A patent/EP1341779B1/de not_active Expired - Lifetime
- 2001-12-11 NZ NZ538100A patent/NZ538100A/en unknown
- 2001-12-11 SI SI200130604T patent/SI1341779T1/sl unknown
- 2001-12-11 IL IL15626801A patent/IL156268A0/xx active IP Right Review Request
- 2001-12-11 WO PCT/US2001/048375 patent/WO2002057252A2/en active Application Filing
- 2001-12-11 DK DK01993277T patent/DK1341779T3/da active
- 2001-12-11 SG SG200503628A patent/SG128491A1/en unknown
- 2001-12-11 EA EA200300674A patent/EA009035B1/ru not_active IP Right Cessation
- 2001-12-11 US US10/014,304 patent/US6610734B2/en not_active Expired - Fee Related
- 2001-12-11 AU AU2002245123A patent/AU2002245123B2/en not_active Ceased
- 2001-12-11 HU HU0303857A patent/HUP0303857A3/hu unknown
- 2001-12-11 CN CNB018205186A patent/CN1263750C/zh not_active Expired - Fee Related
- 2001-12-11 MX MXPA03005255A patent/MXPA03005255A/es active IP Right Grant
- 2001-12-11 NZ NZ526213A patent/NZ526213A/en unknown
- 2001-12-12 AR ARP010105782A patent/AR035516A1/es not_active Application Discontinuation
- 2001-12-12 TW TW090130721A patent/TWI235155B/zh active
-
2003
- 2003-05-28 ZA ZA200304135A patent/ZA200304135B/en unknown
- 2003-06-02 IL IL156268A patent/IL156268A/en not_active IP Right Cessation
- 2003-06-05 US US10/455,674 patent/US6878742B2/en not_active Expired - Fee Related
- 2003-06-11 NO NO20032645A patent/NO328885B1/no not_active IP Right Cessation
-
2004
- 2004-03-02 HK HK04101538A patent/HK1059619A1/xx not_active IP Right Cessation
-
2005
- 2005-03-16 US US11/081,784 patent/US7691884B2/en not_active Expired - Fee Related
-
2006
- 2006-09-14 CY CY20061101305T patent/CY1105441T1/el unknown
-
2008
- 2008-01-17 IL IL188853A patent/IL188853A0/en unknown
-
2009
- 2009-10-09 US US12/576,513 patent/US7842718B2/en not_active Expired - Fee Related
-
2010
- 2010-06-24 JP JP2010144307A patent/JP2010265280A/ja not_active Withdrawn
- 2010-10-19 US US12/907,123 patent/US20110034513A1/en not_active Abandoned
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