DE602004014372D1 - N-pyrrolidin-3-yl-amide-derivate als inhibitoren der serotonin- und noradrenalin-wiederaufnahme - Google Patents
N-pyrrolidin-3-yl-amide-derivate als inhibitoren der serotonin- und noradrenalin-wiederaufnahmeInfo
- Publication number
- DE602004014372D1 DE602004014372D1 DE602004014372T DE602004014372T DE602004014372D1 DE 602004014372 D1 DE602004014372 D1 DE 602004014372D1 DE 602004014372 T DE602004014372 T DE 602004014372T DE 602004014372 T DE602004014372 T DE 602004014372T DE 602004014372 D1 DE602004014372 D1 DE 602004014372D1
- Authority
- DE
- Germany
- Prior art keywords
- noradrenaline
- serotonin
- pyrrolidin
- inhibitors
- recovery
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/14—Nitrogen atoms not forming part of a nitro radical
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/36—Opioid-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB0314048.0A GB0314048D0 (en) | 2003-06-17 | 2003-06-17 | Novel compounds |
US49312603P | 2003-08-06 | 2003-08-06 | |
PCT/IB2004/001943 WO2004110995A1 (en) | 2003-06-17 | 2004-06-07 | N-pyrrolidin-3-yl-amide derivatives as serotonin and noradrenaline re-uptake inhibitors |
Publications (1)
Publication Number | Publication Date |
---|---|
DE602004014372D1 true DE602004014372D1 (de) | 2008-07-24 |
Family
ID=33554153
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE602004014372T Active DE602004014372D1 (de) | 2003-06-17 | 2004-06-07 | N-pyrrolidin-3-yl-amide-derivate als inhibitoren der serotonin- und noradrenalin-wiederaufnahme |
Country Status (31)
Country | Link |
---|---|
US (2) | US7378436B2 (de) |
EP (1) | EP1638933B1 (de) |
JP (1) | JP4137159B2 (de) |
KR (1) | KR100803796B1 (de) |
AP (1) | AP2005003467A0 (de) |
AR (1) | AR044715A1 (de) |
AT (1) | ATE398107T1 (de) |
AU (1) | AU2004247487B2 (de) |
BR (1) | BRPI0411594A (de) |
CA (1) | CA2530159C (de) |
CY (1) | CY1110434T1 (de) |
DE (1) | DE602004014372D1 (de) |
DK (1) | DK1638933T3 (de) |
EA (1) | EA009881B1 (de) |
EC (1) | ECSP056232A (de) |
ES (1) | ES2305776T3 (de) |
HR (2) | HRP20050993A2 (de) |
IL (1) | IL172063A0 (de) |
IS (1) | IS8136A (de) |
MA (1) | MA27885A1 (de) |
MX (1) | MXPA05013960A (de) |
NL (1) | NL1026438C2 (de) |
NZ (1) | NZ544046A (de) |
PA (1) | PA8605301A1 (de) |
PE (1) | PE20050631A1 (de) |
PL (1) | PL1638933T3 (de) |
PT (1) | PT1638933E (de) |
SI (1) | SI1638933T1 (de) |
TW (1) | TW200505852A (de) |
UY (1) | UY28360A1 (de) |
WO (1) | WO2004110995A1 (de) |
Families Citing this family (26)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8017627B2 (en) * | 2000-07-31 | 2011-09-13 | Nycomed Danmark Aps | Fentanyl composition for nasal administration |
EA009881B1 (ru) * | 2003-06-17 | 2008-04-28 | Пфайзер Инк. | Производные n-пирролидин-3-ил-амида в качестве ингибиторов обратного захвата серотонина и норадреналина |
ATE452130T1 (de) | 2004-10-18 | 2010-01-15 | Lilly Co Eli | 1-(hetero)aryl-3-aminopyrrolidinderivate zur verwendung als antagonisten des mglur3-rezeptors |
US7122683B2 (en) | 2004-11-23 | 2006-10-17 | Pfizer Inc. | Amides useful as monoamine re-uptake inhibitors |
GB0425766D0 (en) * | 2004-11-23 | 2004-12-22 | Pfizer Ltd | Novel compounds |
CA2590226A1 (en) * | 2004-12-14 | 2006-06-22 | Pfizer Limited | N-pyrrolidin-3yl-amide derivatives as serotonin and noradrenalin re-uptake inhibitors |
US20090239928A1 (en) * | 2004-12-14 | 2009-09-24 | Paul Vincent Fish | N-Pyrrolidin-3YL-Amide Derivatives As Serotonin and Noradrenalin Re-Uptake Inhibitors |
TWI449692B (zh) | 2005-05-13 | 2014-08-21 | Otsuka Pharma Co Ltd | 吡咯烷化合物(三) |
DK1893603T3 (da) | 2005-06-02 | 2009-11-30 | Hoffmann La Roche | Piperidin-4-YL-amidderivater og anvendelsen deraf som SST-receptorundertype 5-antagonister |
WO2007135530A2 (en) * | 2006-05-22 | 2007-11-29 | Pfizer Limited | Pharmaceutically & veterinarily suitable salt |
US20080014152A1 (en) * | 2006-07-13 | 2008-01-17 | Di Mauro Thomas M | Intranasal delivery of clenbuterol across the cribriform plate and into the brain |
JP5219465B2 (ja) * | 2006-11-10 | 2013-06-26 | 大塚製薬株式会社 | 医薬 |
WO2008093737A1 (ja) * | 2007-01-31 | 2008-08-07 | Dainippon Sumitomo Pharma Co., Ltd. | アミド誘導体 |
JP2010189275A (ja) * | 2007-06-14 | 2010-09-02 | Dainippon Sumitomo Pharma Co Ltd | ナフタレン誘導体 |
US8263652B2 (en) * | 2007-10-31 | 2012-09-11 | Sk Biopharmaceuticals Co., Ltd. | Stabilized pediatric suspension of carisbamate |
AU2008339351B2 (en) * | 2007-12-19 | 2013-02-28 | Sumitomo Dainippon Pharma Co., Ltd. | Bicyclic heterocyclic derivative |
WO2010011811A2 (en) | 2008-07-24 | 2010-01-28 | Theravance, Inc. | 3-(phenoxyphenylmethyl)pyrrolidine compounds |
AR074350A1 (es) | 2008-11-14 | 2011-01-12 | Theravance Inc | Forma cristalina de un compuesto de 4-(2-(2- fluorofenoximetil) fenil ) pipiridina |
EP2419405A1 (de) * | 2009-04-15 | 2012-02-22 | Theravance, Inc. | 3-(phenoxypyrrolidin-3-ylmethyl)heteroaryl-, 3-(phenylpyrrolidin-3-ylmethoxy)heteroaryl- und 3-(heteroarylpyrrolidin-3-ylmethoxy)heterarylverbindungen |
EP2447264A4 (de) | 2009-06-24 | 2012-12-12 | Dainippon Sumitomo Pharma Co | N-substituiertes zyklisches aminoderivat |
KR20120070561A (ko) * | 2009-07-13 | 2012-06-29 | 세라밴스 인코포레이티드 | 3-페녹시메틸피롤리딘 화합물 |
EP2456436B1 (de) * | 2009-07-21 | 2014-06-25 | Theravance, Inc. | 3-phenoxymethylpyrrolidinverbindungen |
WO2011085291A1 (en) * | 2010-01-11 | 2011-07-14 | Theravance, Inc. | 1 - (2 - phenoxymethylphenyl) piperazine compounds as serotonin and norepinephrine reuptake inhibitors |
ES2543064T3 (es) * | 2010-03-22 | 2015-08-14 | Theravance Biopharma R&D Ip, Llc | Compuestos de 1-(2-fenoximetilheteroaril)piperidina y piperazina |
CA2811641A1 (en) | 2010-10-11 | 2012-04-19 | Theravance, Inc. | Serotonin reuptake inhibitors |
US8501964B2 (en) | 2010-12-03 | 2013-08-06 | Theravance, Inc. | Serotonin reuptake inhibitors |
Family Cites Families (24)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE138773C (de) | ||||
US3963745A (en) * | 1972-04-03 | 1976-06-15 | A. H. Robins Company, Incorporated | Method for controlling emesis with N-(1-substituted-3-pyrrolidinyl)benzamides and thiobenzamides |
US4002757A (en) * | 1974-12-26 | 1977-01-11 | A. H. Robins Company, Incorporated | N-(1-substituted-3-pyrrolidinyl)-4-quinolinecarboxamides |
US4020072A (en) * | 1976-05-04 | 1977-04-26 | E. R. Squibb & Sons, Inc. | 5-Aminomethyl-1H-pyrazolo[3,4-b]pyridines |
GB1574419A (en) * | 1977-11-11 | 1980-09-03 | Anphar Sa | Piperidine compounds |
CH628885A5 (en) * | 1978-01-01 | 1982-03-31 | Anphar Sa | Piperidine derivative |
US5130312A (en) * | 1987-07-17 | 1992-07-14 | Janssen Pharmaceutica N.V. | Substituted N-(3-hydroxy-4-piperidinyl)benzamides |
FR2642069B1 (fr) | 1989-01-20 | 1991-04-12 | Rhone Poulenc Sante | Nouveaux derives du benzopyranne, leur preparation et les compositions pharmaceutiques qui les contiennent |
WO1997018813A1 (en) | 1995-11-22 | 1997-05-29 | Merck & Co., Inc. | Inhibitors of farnesyl-protein transferase |
AU4167099A (en) | 1998-06-19 | 2000-01-05 | Nissan Chemical Industries Ltd. | Heterocyclic compounds as hypoglycemic agents |
US6670299B1 (en) * | 1999-07-03 | 2003-12-30 | Northwestern University | Cyclopentadienyl-containing low-valent early transition metal olefin polymerization catalysts |
FR2802206B1 (fr) * | 1999-12-14 | 2005-04-22 | Sod Conseils Rech Applic | Derives de 4-aminopiperidine et leur utilisation en tant que medicament |
EP2138177A1 (de) | 2000-03-03 | 2009-12-30 | Eisai R&D Management Co., Ltd. | Verwendung eines Cholinesterase-Hemmers zur Behandlung von leichten kognitiven Beeinträchtigungen |
WO2001066521A1 (en) * | 2000-03-06 | 2001-09-13 | Acadia Pharmaceuticals, Inc. | Azacyclic compounds for use in the treatment of serotonin related diseases |
EP1319001A1 (de) | 2000-09-22 | 2003-06-18 | Smithkline Beecham Plc | Pyrazolopyridine und pyrazolopyridazine als antidiabetika |
MXPA03001982A (es) | 2000-09-25 | 2004-05-14 | Actelion Pharmaceuticals Ltd | Amino-aza-cicloalcanos sustituidos utiles contra la malaria. |
EP1430027B1 (de) | 2001-09-14 | 2010-09-01 | High Point Pharmaceuticals, LLC | Neue aminoazetidin-, aminopyrrolidin- und aminopiperidinderivative |
CA2468761A1 (en) | 2001-10-31 | 2003-05-08 | Morphochem Aktiengesellschaft Fuer Kombinatorische Chemie | Novel anticancer compounds |
GB0128287D0 (en) | 2001-11-26 | 2002-01-16 | Smithkline Beecham Plc | Novel method and compounds |
NZ537522A (en) * | 2002-06-24 | 2006-07-28 | Acadia Pharm Inc | N-substituted piperidine derivatives as serotonin receptor agents |
AU2003249983A1 (en) | 2002-07-18 | 2004-02-09 | Actelion Pharmaceuticals Ltd | Piperidines useful for the treatment of central nervous system disorders |
AU2003263393A1 (en) | 2002-09-04 | 2004-03-29 | Glenmark Pharmaceuticals Limited | New heterocyclic amide compounds useful for the treatment of inflammatory and allergic disorders: process for their preparation and pharmaceutical compositions containing them |
WO2004058705A2 (en) | 2002-12-20 | 2004-07-15 | Chemocentryx | Inhibitors of the binding of chemokines i-tac or sdf-1 to the ccxckr2 receptor |
EA009881B1 (ru) * | 2003-06-17 | 2008-04-28 | Пфайзер Инк. | Производные n-пирролидин-3-ил-амида в качестве ингибиторов обратного захвата серотонина и норадреналина |
-
2004
- 2004-06-07 EA EA200501730A patent/EA009881B1/ru not_active IP Right Cessation
- 2004-06-07 MX MXPA05013960A patent/MXPA05013960A/es active IP Right Grant
- 2004-06-07 EP EP04736241A patent/EP1638933B1/de active Active
- 2004-06-07 WO PCT/IB2004/001943 patent/WO2004110995A1/en active IP Right Grant
- 2004-06-07 CA CA002530159A patent/CA2530159C/en not_active Expired - Fee Related
- 2004-06-07 AT AT04736241T patent/ATE398107T1/de not_active IP Right Cessation
- 2004-06-07 DE DE602004014372T patent/DE602004014372D1/de active Active
- 2004-06-07 PL PL04736241T patent/PL1638933T3/pl unknown
- 2004-06-07 KR KR1020057024147A patent/KR100803796B1/ko not_active IP Right Cessation
- 2004-06-07 JP JP2006516540A patent/JP4137159B2/ja not_active Expired - Fee Related
- 2004-06-07 DK DK04736241T patent/DK1638933T3/da active
- 2004-06-07 ES ES04736241T patent/ES2305776T3/es active Active
- 2004-06-07 NZ NZ544046A patent/NZ544046A/en unknown
- 2004-06-07 AU AU2004247487A patent/AU2004247487B2/en not_active Expired - Fee Related
- 2004-06-07 PT PT04736241T patent/PT1638933E/pt unknown
- 2004-06-07 BR BRPI0411594-5A patent/BRPI0411594A/pt not_active IP Right Cessation
- 2004-06-07 SI SI200430767T patent/SI1638933T1/sl unknown
- 2004-06-07 AP AP2005003467A patent/AP2005003467A0/xx unknown
- 2004-06-14 PE PE2004000590A patent/PE20050631A1/es not_active Application Discontinuation
- 2004-06-14 UY UY28360A patent/UY28360A1/es not_active Application Discontinuation
- 2004-06-16 PA PA20048605301A patent/PA8605301A1/es unknown
- 2004-06-16 AR ARP040102082A patent/AR044715A1/es not_active Application Discontinuation
- 2004-06-16 TW TW093117317A patent/TW200505852A/zh unknown
- 2004-06-17 NL NL1026438A patent/NL1026438C2/nl not_active IP Right Cessation
- 2004-06-17 US US10/872,160 patent/US7378436B2/en not_active Expired - Fee Related
-
2005
- 2005-11-20 IL IL172063A patent/IL172063A0/en unknown
- 2005-11-21 IS IS8136A patent/IS8136A/is unknown
- 2005-12-14 HR HR20050993A patent/HRP20050993A2/hr not_active Application Discontinuation
- 2005-12-16 MA MA28674A patent/MA27885A1/fr unknown
- 2005-12-16 EC EC2005006232A patent/ECSP056232A/es unknown
-
2008
- 2008-05-21 US US12/124,755 patent/US20080306123A1/en not_active Abandoned
- 2008-07-09 HR HR20080339T patent/HRP20080339T3/xx unknown
- 2008-08-14 CY CY20081100869T patent/CY1110434T1/el unknown
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition |