DE602005007474D1 - Substituierte morpholin- und thiomorpholinderivate - Google Patents

Substituierte morpholin- und thiomorpholinderivate

Info

Publication number
DE602005007474D1
DE602005007474D1 DE602005007474T DE602005007474T DE602005007474D1 DE 602005007474 D1 DE602005007474 D1 DE 602005007474D1 DE 602005007474 T DE602005007474 T DE 602005007474T DE 602005007474 T DE602005007474 T DE 602005007474T DE 602005007474 D1 DE602005007474 D1 DE 602005007474D1
Authority
DE
Germany
Prior art keywords
thiomorpholinderivate
substituierte
morpholin
und
und thiomorpholinderivate
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
DE602005007474T
Other languages
English (en)
Inventor
Tornoee Christian Wenzel
Mario Rottlaender
Nikolay Khanzhin
Andreas Ritzen
William Patrick Watson
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
H Lundbeck AS
Original Assignee
H Lundbeck AS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=37730781&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE602005007474(D1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by H Lundbeck AS filed Critical H Lundbeck AS
Publication of DE602005007474D1 publication Critical patent/DE602005007474D1/de
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/04—1,3-Oxazines; Hydrogenated 1,3-oxazines
    • C07D265/06—1,3-Oxazines; Hydrogenated 1,3-oxazines not condensed with other rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
    • C07D265/30—1,4-Oxazines; Hydrogenated 1,4-oxazines not condensed with other rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D279/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one sulfur atom as the only ring hetero atoms
    • C07D279/10—1,4-Thiazines; Hydrogenated 1,4-thiazines
    • C07D279/12—1,4-Thiazines; Hydrogenated 1,4-thiazines not condensed with other rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
    • C07D295/135—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/82—Benzo [b] furans; Hydrogenated benzo [b] furans with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
    • C07D307/84—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D307/85—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
DE602005007474T 2004-03-12 2005-03-09 Substituierte morpholin- und thiomorpholinderivate Active DE602005007474D1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US55257404P 2004-03-12 2004-03-12
DKPA200400412 2004-03-12
PCT/DK2005/000159 WO2005087754A1 (en) 2004-03-12 2005-03-09 Substituted morpholine and thiomorpholine derivatives

Publications (1)

Publication Number Publication Date
DE602005007474D1 true DE602005007474D1 (en) 2008-07-24

Family

ID=37730781

Family Applications (2)

Application Number Title Priority Date Filing Date
DE602005016849T Active DE602005016849D1 (de) 2004-03-12 2005-03-09 Substituierte Morpholin and Thiomorpholin Derivate
DE602005007474T Active DE602005007474D1 (en) 2004-03-12 2005-03-09 Substituierte morpholin- und thiomorpholinderivate

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DE602005016849T Active DE602005016849D1 (de) 2004-03-12 2005-03-09 Substituierte Morpholin and Thiomorpholin Derivate

Country Status (32)

Country Link
US (6) US7501414B2 (de)
EP (3) EP2138487A1 (de)
JP (1) JP5006184B2 (de)
KR (2) KR20120136422A (de)
CN (2) CN102516204B (de)
AR (1) AR049784A1 (de)
AT (2) ATE398112T1 (de)
AU (1) AU2005221762B2 (de)
BR (1) BRPI0508570B8 (de)
CA (1) CA2559397C (de)
CO (1) CO5721001A2 (de)
CY (2) CY1110392T1 (de)
DE (2) DE602005016849D1 (de)
DK (2) DK1727809T3 (de)
EA (1) EA015120B1 (de)
EG (1) EG25344A (de)
ES (2) ES2306087T3 (de)
HK (1) HK1172618A1 (de)
HR (1) HRP20090685T1 (de)
IL (1) IL177859A (de)
MY (2) MY147786A (de)
NO (1) NO337161B1 (de)
NZ (1) NZ549133A (de)
PL (2) PL1947093T3 (de)
PT (2) PT1727809E (de)
RS (2) RS50606B (de)
SG (1) SG151254A1 (de)
SI (2) SI1727809T1 (de)
TW (2) TWI357901B (de)
UA (2) UA102517C2 (de)
WO (1) WO2005087754A1 (de)
ZA (2) ZA200607286B (de)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7799832B2 (en) 2003-10-23 2010-09-21 Valeant Pharmaceuticals North America Combinations of retigabine and sodium channel inhibitors or sodium channel-influencing active compounds for treating pains
TWI357901B (en) 2004-03-12 2012-02-11 Lundbeck & Co As H Substituted morpholine and thiomorpholine derivati
UA89503C2 (uk) 2004-09-13 2010-02-10 Х. Луннбек А/С Заміщені похідні аніліну
UA92340C2 (en) * 2005-03-03 2010-10-25 Х. Луннбек А/С Substituted pyridine derivatives
AU2006220130B2 (en) 2005-03-03 2011-07-28 H. Lundbeck A/S Substituted pyridine derivatives
CA2641564C (en) * 2006-02-07 2012-06-12 H. Lundbeck A/S Use of kcnq-openers for treating or reducing the symptoms of schizophrenia
US7960436B2 (en) 2006-06-05 2011-06-14 Valeant Pharmaceuticals International Substituted arylamino-1,2,3,4-tetrahydro naphthalenes and-2,3-dihydro-1H-indenes as potassium channel modulators
US8993593B2 (en) 2006-08-23 2015-03-31 Valeant Pharmaceuticals International N-(4-(6-fluoro-3,4-dihydroisoquinolin-2(1H)-yl)-2,6-dimethylphenyl)-3,3-dimethylbutanamide as potassium channel modulators
DK2061465T3 (da) 2006-08-23 2013-07-08 Valeant Pharmaceuticals Int Derivater af 4-(N-azacycloalkyl)anilider som kaliumkanalmodulatorer
EA200900749A1 (ru) 2006-11-28 2009-12-30 Валеант Фармасьютикалс Интернэшнл 1,4-диаминобициклические аналоги ретигабина как модуляторы калиевых каналов
WO2008130616A2 (en) * 2007-04-19 2008-10-30 Schering Corporation Diaryl morpholines as cb1 modulators
US8367684B2 (en) 2007-06-13 2013-02-05 Valeant Pharmaceuticals International Derivatives of 4-(N-azacycloalkyl) anilides as potassium channel modulators
CA2694887A1 (en) * 2007-08-01 2009-02-05 Henriette Husum Bak-Jensen Use of kncq potassium channel openers for reducing symptoms of or treating disorders or conditions wherein the dopaminergic system is disrupted
US7786146B2 (en) 2007-08-13 2010-08-31 Valeant Pharmaceuticals International Derivatives of 5-amino-4,6-disubstituted indole and 5-amino-4,6-disubstituted indoline as potassium channel modulators
JP2010043063A (ja) 2008-05-09 2010-02-25 Agency For Science Technology & Research 川崎病の診断及び治療
WO2010094645A1 (en) * 2009-02-17 2010-08-26 Neurosearch A/S Substituted pyridine derivatives and their medical use
WO2010094644A1 (en) * 2009-02-17 2010-08-26 Neurosearch A/S Substituted pyridine derivatives and their medical use
US20100286138A1 (en) * 2009-05-11 2010-11-11 H. Lundbeck A/S Stable forms of N-(2,6-Dimethyl-4-morpholin-4-yl-phenyl)-3,3-dimethyl-butyramide
TW201041857A (en) * 2009-05-11 2010-12-01 Lundbeck & Co As H Stable forms of N-(2,6-dimethyl-4-morpholin-4-yl-phenyl)-3,3-dimethyl-butyramide
US20120232058A1 (en) * 2009-09-07 2012-09-13 Neurosearch A/S Substituted pyridine derivatives and their medical use
SG186409A1 (en) 2010-07-08 2013-02-28 Pfizer Piperidinyl pyrimidine amides as kv7 potassium channel openers
CN103073455B (zh) 2011-10-25 2015-08-19 中国科学院上海药物研究所 一类新型的kcnq钾通道激动剂、其制备方法和用途
WO2013159095A1 (en) * 2012-04-20 2013-10-24 Anderson Gaweco Ror modulators and their uses
CN103044431A (zh) * 2012-10-22 2013-04-17 中国药科大学 制备五氟磺草胺的新方法
US8652527B1 (en) 2013-03-13 2014-02-18 Upsher-Smith Laboratories, Inc Extended-release topiramate capsules
US9101545B2 (en) 2013-03-15 2015-08-11 Upsher-Smith Laboratories, Inc. Extended-release topiramate capsules
CA2969756A1 (en) * 2014-12-05 2016-06-09 Aquinnah Pharmaceuticals, Inc. Sulfonamide derivatives, compositions and methods of use in the treatment of neurodegenerative diseases
EP3366683A1 (de) * 2017-02-28 2018-08-29 Acousia Therapeutics GmbH Zyklische amide, acetamide und harnstoffe als kalium kanal öffner
WO2020157126A1 (en) 2019-01-29 2020-08-06 Università degli Studi di Salerno Modulators of potassium ion channels and uses thereof
IL282188A (en) * 2021-04-08 2022-11-01 Yeda Res & Dev Combined use of ketamine and bretigabine for the treatment of psychiatric disorders

Family Cites Families (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH03175086A (ja) * 1989-09-14 1991-07-30 Fuji Photo Film Co Ltd ジアゾ感熱記録材料
DE4200259A1 (de) 1992-01-08 1993-07-15 Asta Medica Ag Neue 1,2,4-triaminobenzol-derivate und verfahren zu deren herstellung
US5688792A (en) * 1994-08-16 1997-11-18 Pharmacia & Upjohn Company Substituted oxazine and thiazine oxazolidinone antimicrobials
DE19539861A1 (de) 1995-10-26 1997-04-30 Asta Medica Ag Verwendung von 4-Amino-4-(4-fluorbenzylamino)-1-ethoxy-carbonylaminobenzen zur Prophylaxe und Behandlung der Folgen der akuten und chronischen zerebralen Minderdurchblutung sowie neurodegenerativer Erkrankungen
NZ329200A (en) * 1996-12-16 1999-05-28 Hoechst Ag Sulphonamide substituted quinazoline, isoquinoline, quinoline or benzo[1,3-]oxazine derivatives and medicaments
US6020357A (en) * 1996-12-23 2000-02-01 Dupont Pharmaceuticals Company Nitrogen containing heteroaromatics as factor Xa inhibitors
EP0946508B1 (de) * 1996-12-23 2009-09-23 Bristol-Myers Squibb Pharma Company Stickstoffhaltige heterocyclen als faktor xa-hemmer
US6187797B1 (en) * 1996-12-23 2001-02-13 Dupont Pharmaceuticals Company Phenyl-isoxazoles as factor XA Inhibitors
DE69720773T2 (de) 1996-12-23 2004-01-29 Bristol Myers Squibb Pharma Co SAUERSTOFF ODER SCHWEFEL ENTHALTENDE 5-GLIEDRIGE HETEROAROMATISHE DERIVATIVE ALS FACTOR Xa HEMMER
AU1724499A (en) 1997-12-22 1999-07-12 Du Pont Pharmaceuticals Company Nitrogen containing heteroaromatics with ortho-substituted p1's as factor xa inhibitors
AU3110999A (en) * 1998-03-27 1999-10-18 Du Pont Pharmaceuticals Company Disubstituted pyrazolines and triazolines as factor xa inhibitors
AU772075B2 (en) * 1999-08-04 2004-04-08 Icagen, Inc. Methods for treating or preventing pain and anxiety
US6495550B2 (en) * 1999-08-04 2002-12-17 Icagen, Inc. Pyridine-substituted benzanilides as potassium ion channel openers
US6117900A (en) 1999-09-27 2000-09-12 Asta Medica Aktiengesellschaft Use of retigabine for the treatment of neuropathic pain
US6893858B2 (en) 2000-05-26 2005-05-17 Bristol-Myers Squibb Company Human kcnq5 potassium channel, methods and compositions thereof
WO2001096540A2 (en) 2000-06-11 2001-12-20 Dupont Pharmaceuticals Company Hepatitis c protease exosite for inhibitor design
PE20020044A1 (es) * 2000-06-16 2002-01-30 Upjohn Co Tiazina oxazolidinona
US6589986B2 (en) 2000-12-20 2003-07-08 Wyeth Methods of treating anxiety disorders
CA2434015A1 (en) * 2001-01-16 2002-07-18 Astrazeneca Ab Therapeutic chroman compounds
CA2433950A1 (en) * 2001-01-16 2002-07-18 Timothy Davenport Therapeutic chromone compounds
CN1250519C (zh) * 2001-01-19 2006-04-12 中国人民解放军军事医学科学院毒物药物研究所 具有调节钾通道功能的胺衍生物及其制备方法和应用
US20020183335A1 (en) * 2001-02-20 2002-12-05 Piyasena Hewawasam 2, 4-disubstituted pyrimidine-5-carboxamide derivatives as KCNQ potassium channel modulators
SE0103648D0 (sv) * 2001-11-01 2001-11-01 Astrazeneca Ab Therapeutic quinolone compounds
SE0103649D0 (sv) * 2001-11-01 2001-11-01 Astrazeneca Ab Therapeutic quinoline compounds
TWI357901B (en) * 2004-03-12 2012-02-11 Lundbeck & Co As H Substituted morpholine and thiomorpholine derivati

Also Published As

Publication number Publication date
RS51066B (sr) 2010-10-31
IL177859A0 (en) 2006-12-31
TW200811121A (en) 2008-03-01
NZ549133A (en) 2010-09-30
CA2559397C (en) 2010-08-10
SI1947093T1 (sl) 2010-01-29
JP2007528880A (ja) 2007-10-18
KR20120136422A (ko) 2012-12-18
IL177859A (en) 2013-02-28
BRPI0508570B8 (pt) 2021-05-25
SG151254A1 (en) 2009-04-30
PL1727809T3 (pl) 2008-11-28
AU2005221762B2 (en) 2011-06-09
EA200601686A1 (ru) 2007-02-27
US7501414B2 (en) 2009-03-10
EP2138487A1 (de) 2009-12-30
RS50606B (sr) 2010-05-07
US20100063036A1 (en) 2010-03-11
US7632835B2 (en) 2009-12-15
US20100063033A1 (en) 2010-03-11
CY1110392T1 (el) 2015-04-29
ZA200607286B (en) 2008-04-30
NO20064599L (no) 2006-12-08
BRPI0508570A (pt) 2007-08-14
BRPI0508570B1 (pt) 2018-11-21
KR101411204B1 (ko) 2014-06-23
EA015120B1 (ru) 2011-06-30
EP1947093B1 (de) 2009-09-23
TW200533359A (en) 2005-10-16
CA2559397A1 (en) 2005-09-22
EP1727809A1 (de) 2006-12-06
NO337161B1 (no) 2016-02-01
CO5721001A2 (es) 2007-01-31
TWI349666B (en) 2011-10-01
MY143698A (en) 2011-06-30
ATE398112T1 (de) 2008-07-15
JP5006184B2 (ja) 2012-08-22
SI1727809T1 (sl) 2008-10-31
DE602005016849D1 (de) 2009-11-05
UA90670C2 (en) 2010-05-25
MY147786A (en) 2013-01-31
UA102517C2 (ru) 2013-07-25
ZA200709718B (en) 2008-09-25
AR049784A1 (es) 2006-09-06
EP1947093B9 (de) 2010-03-03
EP1727809B1 (de) 2008-06-11
HRP20090685T1 (hr) 2010-02-28
PL1947093T3 (pl) 2010-02-26
ATE443702T1 (de) 2009-10-15
US20110294787A1 (en) 2011-12-01
CN102516204B (zh) 2016-01-20
EP1947093A1 (de) 2008-07-23
CN102516204A (zh) 2012-06-27
AU2005221762A1 (en) 2005-09-22
PT1947093E (pt) 2009-12-22
HK1172618A1 (zh) 2013-04-26
DK1947093T3 (da) 2010-02-01
KR20060128004A (ko) 2006-12-13
ES2334076T3 (es) 2010-03-04
US20090143369A1 (en) 2009-06-04
US8299075B2 (en) 2012-10-30
ES2306087T3 (es) 2008-11-01
WO2005087754A1 (en) 2005-09-22
CY1109656T1 (el) 2014-08-13
EP1727809B8 (de) 2008-10-29
US7812023B2 (en) 2010-10-12
US20060167248A1 (en) 2006-07-27
EG25344A (en) 2011-12-14
US20090137571A1 (en) 2009-05-28
TWI357901B (en) 2012-02-11
CN1930138A (zh) 2007-03-14
DK1727809T3 (da) 2008-09-29
US8012962B2 (en) 2011-09-06
PT1727809E (pt) 2008-08-13

Similar Documents

Publication Publication Date Title
DE602005025924D1 (en) Royl-coa-desaturase
EP1769743A4 (de) Radiotomograph
DE602005020252D1 (en) Röhrenförmige prothese
EP1793751A4 (de) Kompressor-distraktor
AP2006003810A0 (en) 4-Phenylamino-quinazolin-6-yl-amides
DE602005010905D1 (en) Roboterhandvorrichtung
EP1790281A4 (de) Diopsimeter
DE602005007474D1 (en) Substituierte morpholin- und thiomorpholinderivate
DE602005011286D1 (en) Pyrazolopyridinderivate
DE502005007040D1 (en) Laryngoskop
DE602004014986D1 (en) Terminal-box
DE502005007456D1 (en) Nanoemulsionen
EG23651A (en) Culturama
DE602005008719D1 (en) Notinformationsschild
DE602005026795D1 (en) Polythiourethan
DE602005010119D1 (en) Roboterhandvorrichtung
DE602005010440D1 (en) Lymerdispersionen
DE602005025096D1 (en) Rotationsdämpfer
DE502005009795D1 (en) Modulares gelenkprothesensystem
DE602005003029D1 (en) Polyaminoamidmonoepoxyaddukte
DE502004004685D1 (en) Giessmaschine
DE502005010653D1 (en) Eiten
EP1719466A4 (de) Lithotrit
DE502005006813D1 (en) Common-rail-injektor
DE502004004917D1 (en) Multiaxialkomplex

Legal Events

Date Code Title Description
8364 No opposition during term of opposition