DE60213115D1 - Synthese von cyclosporin-analogen - Google Patents

Synthese von cyclosporin-analogen

Info

Publication number
DE60213115D1
DE60213115D1 DE60213115T DE60213115T DE60213115D1 DE 60213115 D1 DE60213115 D1 DE 60213115D1 DE 60213115 T DE60213115 T DE 60213115T DE 60213115 T DE60213115 T DE 60213115T DE 60213115 D1 DE60213115 D1 DE 60213115D1
Authority
DE
Germany
Prior art keywords
isomers
isa
cyclosporine
derivatives
mixtures
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60213115T
Other languages
English (en)
Other versions
DE60213115T2 (de
Inventor
Selvaraj Naicker
W Yatscoff
T Foster
Mark Abel
Seetharaman Jayaraman
Hans-Jurgen Mair
Jean-Michel Adam
Bruno Lohri
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Isotechnika Inc
Original Assignee
Isotechnika Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Isotechnika Inc filed Critical Isotechnika Inc
Publication of DE60213115D1 publication Critical patent/DE60213115D1/de
Application granted granted Critical
Publication of DE60213115T2 publication Critical patent/DE60213115T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/64—Cyclic peptides containing only normal peptide links
    • C07K7/645—Cyclosporins; Related peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
    • A61K38/13—Cyclosporins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
    • A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
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    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4858—Organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
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    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
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    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/64—Cyclic peptides containing only normal peptide links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/806—Antigenic peptides or proteins
DE2002613115 2001-10-19 2002-10-17 Synthese von cyclosporinanaloga Expired - Lifetime DE60213115T2 (de)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US34620101P 2001-10-19 2001-10-19
US346201P 2001-10-19
US37059602P 2002-04-05 2002-04-05
US370596P 2002-04-05
PCT/CA2002/001559 WO2003033526A2 (en) 2001-10-19 2002-10-17 Synthesis of cyclosporin analogs

Publications (2)

Publication Number Publication Date
DE60213115D1 true DE60213115D1 (en) 2006-08-24
DE60213115T2 DE60213115T2 (de) 2007-02-01

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Family Applications (2)

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DE2002613115 Expired - Lifetime DE60213115T2 (de) 2001-10-19 2002-10-17 Synthese von cyclosporinanaloga
DE60231570T Expired - Lifetime DE60231570D1 (de) 2001-10-19 2002-10-17 Synthese von Cyclosporinanalogen

Family Applications After (1)

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DE60231570T Expired - Lifetime DE60231570D1 (de) 2001-10-19 2002-10-17 Synthese von Cyclosporinanalogen

Country Status (28)

Country Link
US (13) US7141648B2 (de)
EP (2) EP1714977B1 (de)
JP (3) JP4261355B2 (de)
KR (2) KR101006206B1 (de)
CN (1) CN100334106C (de)
AT (2) ATE332917T1 (de)
AU (2) AU2002331509B2 (de)
BR (1) BRPI0213658A8 (de)
CA (1) CA2461740C (de)
CO (1) CO5580836A2 (de)
CY (1) CY1105111T1 (de)
DE (2) DE60213115T2 (de)
DK (2) DK1714977T3 (de)
ES (2) ES2266564T3 (de)
HK (1) HK1062568A1 (de)
HR (2) HRP20040355B1 (de)
IL (3) IL160763A0 (de)
MA (1) MA27293A1 (de)
MX (1) MXPA04003625A (de)
NO (1) NO332459B1 (de)
NZ (1) NZ531944A (de)
PL (2) PL210841B1 (de)
PT (2) PT1436321E (de)
RU (1) RU2321593C9 (de)
SI (1) SI1436321T1 (de)
TN (1) TNSN04068A1 (de)
WO (1) WO2003033526A2 (de)
ZA (1) ZA200402269B (de)

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