DE60223047D1 - Verfahren zu herstellung von aktivierten polyethylenglykolen - Google Patents

Verfahren zu herstellung von aktivierten polyethylenglykolen

Info

Publication number
DE60223047D1
DE60223047D1 DE60223047T DE60223047T DE60223047D1 DE 60223047 D1 DE60223047 D1 DE 60223047D1 DE 60223047 T DE60223047 T DE 60223047T DE 60223047 T DE60223047 T DE 60223047T DE 60223047 D1 DE60223047 D1 DE 60223047D1
Authority
DE
Germany
Prior art keywords
polyethylene glycols
activated polyethylene
preparing activated
sup
npc
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60223047T
Other languages
English (en)
Other versions
DE60223047T2 (de
Inventor
Marie-Pierre Faure
Michel Ibea
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bioartificial Gel Technologies Inc
Original Assignee
Bioartificial Gel Technologies Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bioartificial Gel Technologies Inc filed Critical Bioartificial Gel Technologies Inc
Publication of DE60223047D1 publication Critical patent/DE60223047D1/de
Application granted granted Critical
Publication of DE60223047T2 publication Critical patent/DE60223047T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G65/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
    • C08G65/02—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring
    • C08G65/32—Polymers modified by chemical after-treatment
    • C08G65/329—Polymers modified by chemical after-treatment with organic compounds
    • C08G65/331—Polymers modified by chemical after-treatment with organic compounds containing oxygen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
    • A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G65/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
    • C08G65/02—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring
    • C08G65/32—Polymers modified by chemical after-treatment
    • C08G65/329—Polymers modified by chemical after-treatment with organic compounds
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G65/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
    • C08G65/02—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring
    • C08G65/32—Polymers modified by chemical after-treatment
    • C08G65/329—Polymers modified by chemical after-treatment with organic compounds
    • C08G65/333—Polymers modified by chemical after-treatment with organic compounds containing nitrogen
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L2203/00—Applications
    • C08L2203/02—Applications for biomedical use
DE60223047T 2001-08-22 2002-08-22 Verfahren zur herstellung von aktivierten polyethylenglykolen Expired - Lifetime DE60223047T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US31380101P 2001-08-22 2001-08-22
US313801P 2001-08-22
PCT/CA2002/001306 WO2003018665A1 (en) 2001-08-22 2002-08-22 Process for the preparation of activated polyethylene glycols

Publications (2)

Publication Number Publication Date
DE60223047D1 true DE60223047D1 (de) 2007-11-29
DE60223047T2 DE60223047T2 (de) 2008-07-24

Family

ID=23217202

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60223047T Expired - Lifetime DE60223047T2 (de) 2001-08-22 2002-08-22 Verfahren zur herstellung von aktivierten polyethylenglykolen

Country Status (6)

Country Link
US (1) US7125558B2 (de)
EP (1) EP1419191B1 (de)
AT (1) ATE376020T1 (de)
CA (1) CA2457876C (de)
DE (1) DE60223047T2 (de)
WO (1) WO2003018665A1 (de)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE60214145T2 (de) * 2001-03-08 2007-07-12 Bioartificial Gel Technologies Inc., Montreal An einer rückschicht gebundenes hydrogel und verfahren zur herstellung
CA2457876C (en) 2001-08-22 2011-10-11 Bioartificial Gel Technologies Inc. Process for the preparation of activated polyethylene glycols
CA2576040A1 (en) * 2003-10-21 2005-04-28 Bioartificial Gel Technologies Inc. Hydrogel-containing medical articles and methods of using and making the same
US7351787B2 (en) * 2004-03-05 2008-04-01 Bioartificial Gel Technologies, Inc. Process for the preparation of activated polyethylene glycols
EP1865920A1 (de) * 2005-04-04 2007-12-19 Bioartificial Gel Technologies Inc. Verhütung und behandlung von strahlenbedingter dermatitis
EP1865982A1 (de) * 2005-04-06 2007-12-19 Bioartificial Gel Technologies Inc. Hydrogel-zusammensetzung zur modulierung der topischen entzündungsantwort
US8586078B2 (en) * 2005-12-05 2013-11-19 Rba Pharma Inc. Emulsion-containing medical articles

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US4464468A (en) 1968-03-29 1984-08-07 Agence Nationale De Valorisation De La Recherche (Anvar) Immobilization of active protein by cross-linking to inactive protein
US4179337A (en) 1973-07-20 1979-12-18 Davis Frank F Non-immunogenic polypeptides
IL47468A (en) 1975-06-12 1979-05-31 Rehovot Res Prod Process for the cross-linking of proteins using water soluble cross-linking agents
US4002531A (en) 1976-01-22 1977-01-11 Pierce Chemical Company Modifying enzymes with polyethylene glycol and product produced thereby
CH625702A5 (de) 1977-01-18 1981-10-15 Delalande Sa
US4264155A (en) 1979-07-09 1981-04-28 Opticol Corporation Collagen contact lens
USRE33997E (en) 1981-02-09 1992-07-14 Allergan, Inc. Biologically stabilized compositions comprising collagen as the minor component with ethylenically unsaturated compounds used as contact lenses
US4388428A (en) 1981-07-20 1983-06-14 National Patent Development Corporation Biologically stabilized compositions comprising collagen as the major component with ethylenically unsaturated compounds used as contact lenses
FR2565160B1 (fr) 1984-06-04 1987-03-06 Essilor Int Procede pour la realisation d'une lentille de contact souple en polymere(s) proteique(s) naturel(s), et lentille de contact ainsi obtenue
US4791192A (en) 1986-06-26 1988-12-13 Takeda Chemical Industries, Ltd. Chemically modified protein with polyethyleneglycol
US4752627A (en) 1986-08-13 1988-06-21 Michael Froix Clouding-resistant contact lens compositions
US5114627A (en) 1986-10-16 1992-05-19 Cbs Lens Method for producing a collagen hydrogel
US5051406A (en) 1987-03-04 1991-09-24 Nippon Hypox Laboratories Incorporated Pharmaceutical composition using albumin as a carrier and process for producing the same
FR2617763B1 (fr) 1987-07-07 1989-12-01 Essilor Int Procede de fabrication de lentille de contact en un polymere proteique naturel, par moulage avant reticulation
MX12394A (es) 1987-07-23 1993-12-01 Ciba Geigy Ag Procedimiento par la obtencion de carbamatos de polietilenglicol.
US5214131A (en) 1988-05-06 1993-05-25 Sumitomo Pharmaceuticals Company, Limited Polyethylene glycol derivatives, modified peptides and production thereof
US5324844A (en) 1989-04-19 1994-06-28 Enzon, Inc. Active carbonates of polyalkylene oxides for modification of polypeptides
US5122614A (en) 1989-04-19 1992-06-16 Enzon, Inc. Active carbonates of polyalkylene oxides for modification of polypeptides
US5342940A (en) 1989-05-27 1994-08-30 Sumitomo Pharmaceuticals Company, Limited Polyethylene glycol derivatives, process for preparing the same
US5286637A (en) 1989-08-07 1994-02-15 Debiopharm, S.A. Biologically active drug polymer derivatives and method for preparing same
US5039540A (en) 1989-08-14 1991-08-13 Neophore Technologies, Inc. Freeze dry composition and method for oral administration of drugs, biologicals, nutrients and foodstuffs
US5079018A (en) 1989-08-14 1992-01-07 Neophore Technologies, Inc. Freeze dry composition and method for oral administration of drugs, biologicals, nutrients and foodstuffs
JP3051145B2 (ja) 1990-08-28 2000-06-12 住友製薬株式会社 新規なポリエチレングリコール誘導体修飾ペプチド
US5235028A (en) 1990-08-31 1993-08-10 University Of Minnesota Polyethylene glycol derivatives for solid-phase applications
US5545698A (en) 1990-08-31 1996-08-13 University Of Minnesota Polyethylene glycol derivatives for solid-phase applications
US5229366A (en) 1990-10-23 1993-07-20 Fuji Photo Film Co., Ltd. Peptide-containing polyethylene glycol derivatives and application thereof
US5252714A (en) 1990-11-28 1993-10-12 The University Of Alabama In Huntsville Preparation and use of polyethylene glycol propionaldehyde
US5595732A (en) 1991-03-25 1997-01-21 Hoffmann-La Roche Inc. Polyethylene-protein conjugates
US5281698A (en) 1991-07-23 1994-01-25 Cetus Oncology Corporation Preparation of an activated polymer ester for protein conjugation
IT1260468B (it) 1992-01-29 1996-04-09 Metodo per mantenere l'attivita' di enzimi proteolitici modificati con polietilenglicole
US5284974A (en) 1992-08-11 1994-02-08 Monsanto Company Process for the preparation of thioacetamide
US5382657A (en) 1992-08-26 1995-01-17 Hoffmann-La Roche Inc. Peg-interferon conjugates
US5298643A (en) 1992-12-22 1994-03-29 Enzon, Inc. Aryl imidate activated polyalkylene oxides
US5349001A (en) 1993-01-19 1994-09-20 Enzon, Inc. Cyclic imide thione activated polyalkylene oxides
JP3351476B2 (ja) 1993-01-22 2002-11-25 三菱化学株式会社 リン脂質誘導体及びそれを含有するリポソーム
US5321095A (en) 1993-02-02 1994-06-14 Enzon, Inc. Azlactone activated polyalkylene oxides
US5298410A (en) 1993-02-25 1994-03-29 Sterling Winthrop Inc. Lyophilized formulation of polyethylene oxide modified proteins with increased shelf-life
US5605976A (en) 1995-05-15 1997-02-25 Enzon, Inc. Method of preparing polyalkylene oxide carboxylic acids
US5643575A (en) 1993-10-27 1997-07-01 Enzon, Inc. Non-antigenic branched polymer conjugates
US5446090A (en) * 1993-11-12 1995-08-29 Shearwater Polymers, Inc. Isolatable, water soluble, and hydrolytically stable active sulfones of poly(ethylene glycol) and related polymers for modification of surfaces and molecules
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KR19990007804A (ko) 1995-04-14 1999-01-25 가타오카가즈노리 한쪽 말단에 당을, 다른쪽 말단에 상이한 작용기를 갖는 폴리에틸렌 옥사이드 및 이의 제조방법
US6214966B1 (en) 1996-09-26 2001-04-10 Shearwater Corporation Soluble, degradable poly(ethylene glycol) derivatives for controllable release of bound molecules into solution
WO1999057155A1 (en) 1998-05-01 1999-11-11 The Procter & Gamble Company Laundry detergent and/or fabric care compositions comprising a modified antimicrobial protein
DE19903655A1 (de) 1999-01-29 2000-08-10 Beiersdorf Ag Proteinhaltige Hydrogele
US6348558B1 (en) * 1999-12-10 2002-02-19 Shearwater Corporation Hydrolytically degradable polymers and hydrogels made therefrom
DK1280849T3 (da) 2000-04-04 2007-01-08 Bioartificial Gel Technologies Inc Fremgangsmåde til fremstilling af proteinbaserede hydrogeler
DE60214145T2 (de) 2001-03-08 2007-07-12 Bioartificial Gel Technologies Inc., Montreal An einer rückschicht gebundenes hydrogel und verfahren zur herstellung
US7615593B2 (en) * 2001-04-23 2009-11-10 Wisconsin Alumni Research Foundation Bifunctional-modified hydrogels
CA2457876C (en) 2001-08-22 2011-10-11 Bioartificial Gel Technologies Inc. Process for the preparation of activated polyethylene glycols

Also Published As

Publication number Publication date
US20050080206A1 (en) 2005-04-14
CA2457876A1 (en) 2003-03-06
EP1419191B1 (de) 2007-10-17
DE60223047T2 (de) 2008-07-24
WO2003018665A1 (en) 2003-03-06
ATE376020T1 (de) 2007-11-15
EP1419191A1 (de) 2004-05-19
CA2457876C (en) 2011-10-11
US7125558B2 (en) 2006-10-24

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Legal Events

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8364 No opposition during term of opposition