DE60223923D1 - Prodrugs von gaba-analoga, zusammensetzungen und ihre verwendungszwecke - Google Patents
Prodrugs von gaba-analoga, zusammensetzungen und ihre verwendungszweckeInfo
- Publication number
- DE60223923D1 DE60223923D1 DE60223923T DE60223923T DE60223923D1 DE 60223923 D1 DE60223923 D1 DE 60223923D1 DE 60223923 T DE60223923 T DE 60223923T DE 60223923 T DE60223923 T DE 60223923T DE 60223923 D1 DE60223923 D1 DE 60223923D1
- Authority
- DE
- Germany
- Prior art keywords
- prodrugs
- compositions
- progrugs
- gaba analogs
- gaba analogue
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- BTCSSZJGUNDROE-UHFFFAOYSA-N gamma-aminobutyric acid Chemical class NCCCC(O)=O BTCSSZJGUNDROE-UHFFFAOYSA-N 0.000 title abstract 6
- 239000000203 mixture Substances 0.000 title 1
- 239000000651 prodrug Substances 0.000 abstract 5
- 229940002612 prodrug Drugs 0.000 abstract 5
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 abstract 2
- 201000010099 disease Diseases 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C201/00—Preparation of esters of nitric or nitrous acid or of compounds containing nitro or nitroso groups bound to a carbon skeleton
- C07C201/06—Preparation of nitro compounds
- C07C201/12—Preparation of nitro compounds by reactions not involving the formation of nitro groups
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
- C07C229/06—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton
- C07C229/10—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton the nitrogen atom of the amino group being further bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings
- C07C229/12—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton the nitrogen atom of the amino group being further bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings to carbon atoms of acyclic carbon skeletons
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- A61K31/19—Carboxylic acids, e.g. valproic acid
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- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid, pantothenic acid
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- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
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- C07C271/06—Esters of carbamic acids
- C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
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- C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
- C07C323/57—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups
- C07C323/58—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups with amino groups bound to the carbon skeleton
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- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
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- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/14—The ring being saturated
Applications Claiming Priority (8)
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US29752101P | 2001-06-11 | 2001-06-11 | |
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US29851401P | 2001-06-14 | 2001-06-14 | |
US298514P | 2001-06-14 | ||
US36609002P | 2002-03-19 | 2002-03-19 | |
US366090P | 2002-03-19 | ||
PCT/US2002/018689 WO2002100347A2 (en) | 2001-06-11 | 2002-06-11 | Prodrugs of gaba analogs, compositions and uses thereof |
EP02744314A EP1404324B2 (de) | 2001-06-11 | 2002-06-11 | Prodrugs von gaba-analoga, zusammensetzungen und ihre verwendungszwecke |
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DE60223923D1 true DE60223923D1 (de) | 2008-01-17 |
DE60223923T2 DE60223923T2 (de) | 2008-11-13 |
DE60223923T3 DE60223923T3 (de) | 2013-05-16 |
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DE60223923T Expired - Lifetime DE60223923T3 (de) | 2001-06-11 | 2002-06-11 | Prodrugs von gaba-analoga, zusammensetzungen und ihre verwendungszwecke |
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EP (4) | EP2085087A1 (de) |
JP (4) | JP4216713B2 (de) |
KR (5) | KR100958552B1 (de) |
CN (1) | CN1533270A (de) |
AT (2) | ATE540678T1 (de) |
AU (4) | AU2002310409C1 (de) |
CA (2) | CA2449673A1 (de) |
CY (1) | CY1107894T1 (de) |
DE (1) | DE60223923T3 (de) |
DK (1) | DK1404324T4 (de) |
ES (2) | ES2380287T3 (de) |
HK (2) | HK1087628A1 (de) |
HU (2) | HUP0400167A3 (de) |
IL (5) | IL159300A0 (de) |
MX (2) | MXPA03011566A (de) |
NO (4) | NO333756B1 (de) |
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PT (1) | PT1404324E (de) |
WO (2) | WO2002100392A1 (de) |
ZA (1) | ZA200309679B (de) |
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