DE60237531D1 - Verfahren zum trennen von seltenen zellen von fluidproben - Google Patents

Verfahren zum trennen von seltenen zellen von fluidproben

Info

Publication number
DE60237531D1
DE60237531D1 DE60237531T DE60237531T DE60237531D1 DE 60237531 D1 DE60237531 D1 DE 60237531D1 DE 60237531 T DE60237531 T DE 60237531T DE 60237531 T DE60237531 T DE 60237531T DE 60237531 D1 DE60237531 D1 DE 60237531D1
Authority
DE
Germany
Prior art keywords
enrichment
disconnecting
cells
rare cells
fluid samples
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60237531T
Other languages
English (en)
Inventor
Douglas Yamanishi
Paul Hujsak
Zhaohuai Yang
Junquan Xu
Xiaobo Wang
Lei Wu
Mingxian Huang
Guoliang Tao
Jing Tsinghua Uni Cheng
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Aviva Biosciences Corp
Original Assignee
Aviva Biosciences Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aviva Biosciences Corp filed Critical Aviva Biosciences Corp
Application granted granted Critical
Publication of DE60237531D1 publication Critical patent/DE60237531D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume, or surface-area of porous materials
    • G01N15/04—Investigating sedimentation of particle suspensions
    • G01N15/05—Investigating sedimentation of particle suspensions in blood
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
    • A61M1/3616—Batch-type treatment
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
    • A61M1/3618—Magnetic separation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
    • A61M1/362—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits changing physical properties of target cells by binding them to added particles to facilitate their subsequent separation from other cells, e.g. immunoaffinity
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
    • A61M1/3679—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits by absorption
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00—Sampling; Preparing specimens for investigation
    • G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
    • G01N1/40—Concentrating samples
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume, or surface-area of porous materials
    • G01N15/02—Investigating particle size or size distribution
    • G01N15/0272—Investigating particle size or size distribution with screening; with classification by filtering
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/483—Physical analysis of biological material
    • G01N33/487—Physical analysis of biological material of liquid biological material
    • G01N33/49—Blood
    • G01N33/491—Blood by separating the blood components
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume, or surface-area of porous materials
    • G01N15/02—Investigating particle size or size distribution
    • G01N2015/0288—Sorting the particles
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume, or surface-area of porous materials
    • G01N15/02—Investigating particle size or size distribution
    • G01N2015/0294—Particle shape
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume, or surface-area of porous materials
    • G01N15/06—Investigating concentration of particle suspensions
    • G01N2015/0681—Purposely modifying particles, e.g. humidifying for growing
DE60237531T 2001-10-11 2002-10-10 Verfahren zum trennen von seltenen zellen von fluidproben Expired - Lifetime DE60237531D1 (de)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US32872401P 2001-10-11 2001-10-11
US34822801P 2001-10-29 2001-10-29
US39451702P 2002-07-09 2002-07-09
PCT/US2002/032670 WO2003031938A2 (en) 2001-10-11 2002-10-10 Methods, compositions, and automated systems for separating rare cells from fluid samples

Publications (1)

Publication Number Publication Date
DE60237531D1 true DE60237531D1 (de) 2010-10-14

Family

ID=27406620

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60237531T Expired - Lifetime DE60237531D1 (de) 2001-10-11 2002-10-10 Verfahren zum trennen von seltenen zellen von fluidproben

Country Status (8)

Country Link
US (1) US6949355B2 (de)
EP (2) EP2156879A3 (de)
AT (1) ATE479490T1 (de)
AU (1) AU2002334989A1 (de)
CA (1) CA2462914A1 (de)
DE (1) DE60237531D1 (de)
DK (1) DK1439897T3 (de)
WO (1) WO2003031938A2 (de)

Families Citing this family (186)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7244349B2 (en) * 1997-12-17 2007-07-17 Molecular Devices Corporation Multiaperture sample positioning and analysis system
CA2316966C (en) 1997-12-17 2008-04-08 Horst Vogel Positioning and electrophysiological characterization of individual cells and reconstituted membrane systems on microstructured carriers
US20020144905A1 (en) * 1997-12-17 2002-10-10 Christian Schmidt Sample positioning and analysis system
US7329388B2 (en) * 1999-11-08 2008-02-12 Princeton Biochemicals, Inc. Electrophoresis apparatus having staggered passage configuration
US6406604B1 (en) * 1999-11-08 2002-06-18 Norberto A. Guzman Multi-dimensional electrophoresis apparatus
US7270730B2 (en) * 2000-08-04 2007-09-18 Essen Instruments, Inc. High-throughput electrophysiological measurement system
US7067046B2 (en) * 2000-08-04 2006-06-27 Essen Instruments, Inc. System for rapid chemical activation in high-throughput electrophysiological measurements
US6913697B2 (en) 2001-02-14 2005-07-05 Science & Technology Corporation @ Unm Nanostructured separation and analysis devices for biological membranes
US8986944B2 (en) 2001-10-11 2015-03-24 Aviva Biosciences Corporation Methods and compositions for separating rare cells from fluid samples
US8980568B2 (en) 2001-10-11 2015-03-17 Aviva Biosciences Corporation Methods and compositions for detecting non-hematopoietic cells from a blood sample
US7166443B2 (en) * 2001-10-11 2007-01-23 Aviva Biosciences Corporation Methods, compositions, and automated systems for separating rare cells from fluid samples
US20140008210A1 (en) 2012-07-06 2014-01-09 Aviva Biosciences Corporation Methods and compositions for separating or enriching cells
AU2003216175A1 (en) 2002-02-04 2003-09-02 Colorado School Of Mines Laminar flow-based separations of colloidal and cellular particles
JP2004016045A (ja) * 2002-06-13 2004-01-22 Olympus Corp 培養装置
WO2004000444A1 (en) * 2002-06-19 2003-12-31 Northwest Biotherapeutics, Inc. Tangential flow filtration devices and methods for leukocyte enrichment
ES2375724T3 (es) 2002-09-27 2012-03-05 The General Hospital Corporation Dispositivo microflu�?dico para seperación de células y sus usos.
WO2004055198A2 (en) * 2002-12-12 2004-07-01 Chiron Corporation Device and method for in-line blood testing using biochips
US20040232075A1 (en) * 2003-01-31 2004-11-25 Jason Wells Microfiltration device and method for washing and concentrating solid particles
EP1462173A1 (de) * 2003-03-28 2004-09-29 Interuniversitair Micro-Elektronica Centrum (IMEC) Verfahren zu kontrolliertem Transport von magenetischen Partikeln und zugehörige Vorrichtung
US20040259076A1 (en) * 2003-06-23 2004-12-23 Accella Scientific, Inc. Nano and micro-technology virus detection method and device
ATE498680T1 (de) * 2003-10-10 2011-03-15 Asahi Kasei Kuraray Medical Co Verfahren zur herstellung eines zellkonzentrats und einer zellzusammensetzung
WO2005047882A2 (en) * 2003-11-07 2005-05-26 Princeton Biochemicals, Inc. Multi-dimensional electrophoresis apparatus
US8007724B2 (en) * 2003-11-07 2011-08-30 Princeton Biochemicals, Inc. Electrophoresis apparatus having at least one auxiliary buffer passage
US7790039B2 (en) * 2003-11-24 2010-09-07 Northwest Biotherapeutics, Inc. Tangential flow filtration devices and methods for stem cell enrichment
US7163611B2 (en) * 2003-12-03 2007-01-16 Palo Alto Research Center Incorporated Concentration and focusing of bio-agents and micron-sized particles using traveling wave grids
US20050153309A1 (en) 2003-12-22 2005-07-14 David Hoon Method and apparatus for in vivo surveillance of circulating biological components
US7384791B2 (en) * 2004-01-21 2008-06-10 Hewlett-Packard Development Company, L.P. Method of analyzing blood
US8101431B2 (en) 2004-02-27 2012-01-24 Board Of Regents, The University Of Texas System Integration of fluids and reagents into self-contained cartridges containing sensor elements and reagent delivery systems
US7160425B2 (en) * 2004-03-25 2007-01-09 Hewlett-Packard Development Company, L.P. Cell transporter for a biodevice
US7390387B2 (en) * 2004-03-25 2008-06-24 Hewlett-Packard Development Company, L.P. Method of sorting cells in series
US7390388B2 (en) * 2004-03-25 2008-06-24 Hewlett-Packard Development Company, L.P. Method of sorting cells on a biodevice
US7670596B2 (en) * 2004-04-23 2010-03-02 Bioe, Inc. Multi-lineage progenitor cells
US7622108B2 (en) * 2004-04-23 2009-11-24 Bioe, Inc. Multi-lineage progenitor cells
US7340957B2 (en) 2004-07-29 2008-03-11 Los Alamos National Security, Llc Ultrasonic analyte concentration and application in flow cytometry
KR101290558B1 (ko) * 2004-07-30 2013-07-31 퓨리셀렉트 게엠베하 생물학적 연구를 포함하는 생명공학 및 의약적 진단학에서,동물에의 적용을 목적으로, 체액으로부터 세포, 생체 입자및/또는 분자를 분리하는 장치 및 방법
GB0419059D0 (en) * 2004-08-26 2004-09-29 Ici Plc Sediment assessment
DE602005026143D1 (de) * 2004-10-06 2011-03-10 Wellstat Biologics Corp Erkennung eines erhöhten spiegels von her-2/neu-proteinen in zirkulierenden krebszellen und dessen behandlung
JP4477474B2 (ja) * 2004-11-15 2010-06-09 株式会社日立製作所 糞便懸濁ろ過用容器
WO2006079007A2 (en) * 2005-01-21 2006-07-27 President And Fellows Of Harvard College Microconcentrator/microfilter
US20070196820A1 (en) * 2005-04-05 2007-08-23 Ravi Kapur Devices and methods for enrichment and alteration of cells and other particles
ATE490462T1 (de) * 2005-04-08 2010-12-15 Medical Discovery Partners Llc Verfahren zum anreichern von subpopulationen seltener zellen aus dem blut
US8377398B2 (en) 2005-05-31 2013-02-19 The Board Of Regents Of The University Of Texas System Methods and compositions related to determination and use of white blood cell counts
US8921102B2 (en) 2005-07-29 2014-12-30 Gpb Scientific, Llc Devices and methods for enrichment and alteration of circulating tumor cells and other particles
US7993821B2 (en) * 2005-08-11 2011-08-09 University Of Washington Methods and apparatus for the isolation and enrichment of circulating tumor cells
US8173413B2 (en) * 2005-08-11 2012-05-08 University Of Washington Separation and concentration of biological cells and biological particles using a one-dimensional channel
WO2007028084A2 (en) 2005-09-01 2007-03-08 Canon U.S. Life Sciences, Inc. Method and molecular diagnostic device for detection, analysis and identification of genomic dna
AU2006292394A1 (en) * 2005-09-15 2007-03-29 Artemis Health, Inc. Systems and methods for enrichment of analytes
US20110033922A1 (en) * 2005-10-04 2011-02-10 Landers James P Microchip-based acoustic trapping or capture of cells for forensic analysis and related method thereof
KR101157175B1 (ko) * 2005-12-14 2012-07-03 삼성전자주식회사 세포 또는 바이러스의 농축 및 용해용 미세유동장치 및방법
US7279028B2 (en) * 2005-12-17 2007-10-09 Airinspace B.V. Electrostatic filter
KR100745754B1 (ko) * 2005-12-29 2007-08-02 삼성전자주식회사 금속 기둥 전극 구조를 포함하는 유전 영동을 이용하여입자를 조작하기 위한 장치 및 그를 이용하여 빠른유속으로 유전 영동에 의하여 입자를 조작할 수 있는 방법
WO2007079250A2 (en) * 2005-12-29 2007-07-12 Cellpoint Diagnostics, Inc. Devices and methods for enrichment and alteration of circulating tumor cells and other particles
US9487812B2 (en) 2012-02-17 2016-11-08 Colorado School Of Mines Optical alignment deformation spectroscopy
US9885644B2 (en) 2006-01-10 2018-02-06 Colorado School Of Mines Dynamic viscoelasticity as a rapid single-cell biomarker
US9878326B2 (en) 2007-09-26 2018-01-30 Colorado School Of Mines Fiber-focused diode-bar optical trapping for microfluidic manipulation
EP2019858B1 (de) * 2006-04-17 2012-06-13 BioE LLC Differenzierung von vorläuferzellen mit mehreren abstammungslinien in respiratorischen epithelzellen
US7598089B2 (en) * 2006-04-19 2009-10-06 Bioe, Inc. Methods and compositions for separating cells
US20080050739A1 (en) 2006-06-14 2008-02-28 Roland Stoughton Diagnosis of fetal abnormalities using polymorphisms including short tandem repeats
EP2589668A1 (de) 2006-06-14 2013-05-08 Verinata Health, Inc Analyse seltener Zellen mittels Probentrennung und DNA-Etiketten
US20080070792A1 (en) 2006-06-14 2008-03-20 Roland Stoughton Use of highly parallel snp genotyping for fetal diagnosis
US8137912B2 (en) 2006-06-14 2012-03-20 The General Hospital Corporation Methods for the diagnosis of fetal abnormalities
US20070292889A1 (en) * 2006-06-16 2007-12-20 The Regents Of The University Of California Immunoassay magnetic trapping device
US20080057505A1 (en) * 2006-07-14 2008-03-06 Ping Lin Methods and compositions for detecting rare cells from a biological sample
CN101583722A (zh) * 2006-07-14 2009-11-18 阿维瓦生物科学股份有限公司 从生物学样品检测稀有细胞的方法和组合物
US7862813B2 (en) * 2006-07-29 2011-01-04 Bjork Jr Robert Lamar Bi-specific monoclonal antibody (specific for both CD3 and CD11b) therapeutic drug
US8158411B2 (en) * 2006-08-21 2012-04-17 Samsung Electronics Co., Ltd. Method of separating microorganism using nonplanar solid substrate and device for separating microorganism using the same
US7835000B2 (en) 2006-11-03 2010-11-16 Los Alamos National Security, Llc System and method for measuring particles in a sample stream of a flow cytometer or the like
KR100844532B1 (ko) * 2006-12-28 2008-07-08 한국기계연구원 적혈구 침강속도 측정기
US8999636B2 (en) * 2007-01-08 2015-04-07 Toxic Report Llc Reaction chamber
US20140011290A1 (en) * 2007-01-16 2014-01-09 Roche Diagnostics Operations, Inc. Collection of liquid analytical samples for clinical analytical purpose and device thereof
US7691602B1 (en) 2007-03-02 2010-04-06 Hanson Technologies, Inc. Agricultural screening system and method for detection of infectious microorganisms
KR20090121297A (ko) * 2007-03-02 2009-11-25 스미쓰 앤드 네퓨 피엘씨 생물학적 시료의 여과시 초음파, 역세정 및 필터 이동에 의한 필터 세정용 기기 및 방법
ATE538377T1 (de) 2007-04-02 2012-01-15 Acoustic Cytometry Systems Inc Verfahren zur verbesserten analyse von in einem akustischen feld fokussierten zellen und partikeln
US7837040B2 (en) * 2007-04-09 2010-11-23 Los Alamos National Security, Llc Acoustic concentration of particles in fluid flow
US8083068B2 (en) 2007-04-09 2011-12-27 Los Alamos National Security, Llc Apparatus for separating particles utilizing engineered acoustic contrast capture particles
MX2009011228A (es) * 2007-04-19 2009-11-02 Wellstat Biologics Corp Deteccion de niveles elevados de la proteina her-2/neu de celulas cancerosas circulantes no aisladas y tratamiento.
ITTO20070307A1 (it) 2007-05-04 2008-11-05 Silicon Biosystems Spa Metodo e dispositivo per la diagnosi prenatale non-invasiva
US20080277332A1 (en) * 2007-05-11 2008-11-13 Becton, Dickinson And Company Micromachined membrane filter device for a glaucoma implant and method for making the same
GB0724404D0 (en) * 2007-05-29 2008-01-30 Invitrogen Dynal As A sample vessel retaining portion
US9199247B2 (en) * 2007-05-29 2015-12-01 Invitrogen Dynal As Magnetic separation rack
WO2008156688A2 (en) * 2007-06-15 2008-12-24 Purdue Research Foundation Nonlinear magnetophoretic separation of biological substances
US8841135B2 (en) 2007-06-20 2014-09-23 University Of Washington Biochip for high-throughput screening of circulating tumor cells
EP2006373A1 (de) * 2007-06-21 2008-12-24 Hera Diagnostics Verfahren zur Trennung von biologischen Objekten anhand ihrer viskoelastischen Eigenschaften
US10722250B2 (en) 2007-09-04 2020-07-28 Colorado School Of Mines Magnetic-field driven colloidal microbots, methods for forming and using the same
US7655124B2 (en) * 2007-10-05 2010-02-02 Mady Attila Apparatus to assist platelet manipulation to prevent and treat endovascular disease and its sequelae
US8528406B2 (en) 2007-10-24 2013-09-10 Los Alamos National Security, LLP Method for non-contact particle manipulation and control of particle spacing along an axis
US8263407B2 (en) 2007-10-24 2012-09-11 Los Alamos National Security, Llc Method for non-contact particle manipulation and control of particle spacing along an axis
ES2640216T3 (es) * 2007-12-07 2017-11-02 Miltenyi Biotec Gmbh Sistemas y métodos para procesamiento de células
US8266951B2 (en) 2007-12-19 2012-09-18 Los Alamos National Security, Llc Particle analysis in an acoustic cytometer
EP2087934A1 (de) * 2008-02-07 2009-08-12 Qiagen GmbH Verfahren und Vorrichtung zur automatisierten Prozessierung einer Probe
US8857279B2 (en) * 2008-03-03 2014-10-14 William P. Hanson Analyte screening and detection systems and methods
AU2009232597A1 (en) * 2008-03-31 2009-10-08 Japan Tobacco Inc. Quantitation method of virus
FI20085299A0 (fi) * 2008-04-10 2008-04-10 Valtion Teknillinen Mikrofluidistisia siruvälineitä ja niiden käyttö
WO2009143241A2 (en) * 2008-05-21 2009-11-26 Bioe, Inc. Differentiation of multi-lineage progenitor cells to pancreatic cells
SI2334812T1 (sl) 2008-09-20 2017-05-31 The Board of Trustees of the Leland Stanford Junior University Office of the General Counsel Building 170 Neinvazivna diagnoza fetalne anevploidije s sekvenciranjem
US8361716B2 (en) * 2008-10-03 2013-01-29 Pathogenetix, Inc. Focusing chamber
EP2352533B1 (de) * 2008-12-01 2018-01-10 General Electric Company System und verfahren zum trennen von nukleierten zellen aus körperflüssigkeiten
US20160252434A1 (en) * 2014-04-16 2016-09-01 General Electric Company Gamma sterilized dextran solutions and methods of use
US8961787B2 (en) * 2008-12-01 2015-02-24 General Electric Company Systems and methods for processing complex biological materials
US20150299657A1 (en) * 2014-04-16 2015-10-22 General Electric Company Gamma stabilized dextran solutions and methods of use
KR101796906B1 (ko) 2009-03-24 2017-11-10 유니버시티 오브 시카고 반응을 수행하기 위한 방법
US9464319B2 (en) 2009-03-24 2016-10-11 California Institute Of Technology Multivolume devices, kits and related methods for quantification of nucleic acids and other analytes
US10196700B2 (en) 2009-03-24 2019-02-05 University Of Chicago Multivolume devices, kits and related methods for quantification and detection of nucleic acids and other analytes
US9447461B2 (en) 2009-03-24 2016-09-20 California Institute Of Technology Analysis devices, kits, and related methods for digital quantification of nucleic acids and other analytes
US9447467B2 (en) 2009-04-21 2016-09-20 Genetic Technologies Limited Methods for obtaining fetal genetic material
US9034280B2 (en) 2009-12-16 2015-05-19 General Electric Corporation High-throughput methods and systems for processing biological materials
SE0951009A1 (sv) * 2009-12-22 2011-06-23 Anordning och förfarande för rening och anrikning av biologiskt prov
CN102762712A (zh) * 2010-01-21 2012-10-31 百赛普有限公司 稀有细胞的磁性分离
FR2956868B1 (fr) * 2010-03-01 2014-01-10 Bio Rad Pasteur Procede rapide de detection d'enzymes et de microorganismes
US8774488B2 (en) 2010-03-11 2014-07-08 Cellscape Corporation Method and device for identification of nucleated red blood cells from a maternal blood sample
ITTO20100068U1 (it) * 2010-04-20 2011-10-21 Eltek Spa Dispositivi microfluidici e/o attrezzature per dispositivi microfluidici
US20120040843A1 (en) * 2010-08-12 2012-02-16 Dublin City University Centrifugal capture system
CA2826111A1 (en) * 2011-01-31 2012-08-09 Esoterix Genetic Laboratories, Llc Methods for enriching microparticles or nucleic acids in a complex mixture using size exclusion filtration
US9494557B2 (en) 2011-04-05 2016-11-15 Purdue Research Foundation Micro-fluidic system using micro-apertures for high throughput detection of cells
EP2717937B1 (de) * 2011-06-10 2016-05-25 Dualis Medtech GmbH Portable dialysevorrichtung
US9541480B2 (en) 2011-06-29 2017-01-10 Academia Sinica Capture, purification, and release of biological substances using a surface coating
US20130122492A1 (en) * 2011-11-14 2013-05-16 Kellbenx Inc. Detection, isolation and analysis of rare cells in biological fluids
ES2602500T3 (es) * 2011-11-25 2017-02-21 Miltenyi Biotec Gmbh Método de separación celular
US8685708B2 (en) * 2012-04-18 2014-04-01 Pathogenetix, Inc. Device for preparing a sample
US20150076049A1 (en) * 2012-04-20 2015-03-19 Agency For Science, Technology And Research Microfilter and apparatus for separating a biological entity from a sample volume
WO2013158044A1 (en) * 2012-04-20 2013-10-24 Agency For Science, Technology And Research Apparatus and method for separating a biological entity from a sample volume
CN104620099B (zh) * 2012-07-16 2018-01-02 吉恩弗路迪克斯公司 用于在样本的动电处理中使用的参数的样本相关选择
EP2897729A4 (de) * 2012-09-18 2016-05-25 Cynvenio Biosystems Inc Flüssigkeitsbehälter
CA2942831A1 (en) 2013-03-15 2014-09-18 The Trustees Of Princeton University Methods and devices for high throughput purification
CN110186835B (zh) 2013-03-15 2022-05-31 Gpb科学有限公司 颗粒的片上微流体处理
US20150064153A1 (en) 2013-03-15 2015-03-05 The Trustees Of Princeton University High efficiency microfluidic purification of stem cells to improve transplants
CA3026548C (en) 2013-04-15 2022-01-04 Becton, Dickinson And Company Medical device for collection of a biological sample
JP6177996B2 (ja) 2013-04-15 2017-08-09 ベクトン・ディキンソン・アンド・カンパニーＢｅｃｔｏｎ， Ｄｉｃｋｉｎｓｏｎ Ａｎｄ Ｃｏｍｐａｎｙ 生体液収集装置および生体液分離試験システム
MX368793B (es) 2013-04-15 2019-10-16 Becton Dickinson Co Dispositivo de recogida de fluidos biologicos y sistema de separacion y analisis de fluidos biologicos.
JP6174785B2 (ja) 2013-04-15 2017-08-02 ベクトン・ディキンソン・アンド・カンパニーＢｅｃｔｏｎ， Ｄｉｃｋｉｎｓｏｎ Ａｎｄ Ｃｏｍｐａｎｙ 生物学的流体分離デバイスならびに生物学的流体分離および検査システム
CA2909359C (en) 2013-04-15 2018-07-10 Becton, Dickinson And Company Biological fluid collection device and biological fluid separation and testing system
BR112015026222B1 (pt) 2013-04-15 2022-05-17 Becton, Dickinson And Company Dispositivo de coleta de amostra de fluido biológico e sistema de exame de fluido biológico
JP6339663B2 (ja) 2013-04-15 2018-06-06 ベクトン・ディキンソン・アンド・カンパニーＢｅｃｔｏｎ， Ｄｉｃｋｉｎｓｏｎ Ａｎｄ Ｃｏｍｐａｎｙ 生体液採集装置、および、生体液採集検査システム
CA2909186C (en) 2013-04-15 2019-01-22 Becton, Dickinson And Company Medical device for collection of a biological sample
JP6267319B2 (ja) 2013-04-15 2018-01-24 ベクトン・ディキンソン・アンド・カンパニーＢｅｃｔｏｎ， Ｄｉｃｋｉｎｓｏｎ Ａｎｄ Ｃｏｍｐａｎｙ 生物学的流体移送デバイスおよび生物学的流体サンプリングシステム
MX369605B (es) 2013-04-15 2019-11-13 Becton Dickinson Co Dispositivo de transferencia de muestreo de fluidos biologicos y sistema de separacion y analisis de fluidos biologicos.
CA2909183C (en) 2013-04-15 2020-08-04 Craig A. Gelfand Blood sampling transfer device
EP2986382A1 (de) 2013-04-15 2016-02-24 Becton, Dickinson and Company Blutentnahme- und -übertragungsvorrichtung sowie bluttrennungs- und -testsystem
GB201306810D0 (en) 2013-04-15 2013-05-29 Cells4Life Group Llp Methods of cell separation
ES2958415T3 (es) 2013-04-15 2024-02-08 Becton Dickinson Co Dispositivo de separación de fluidos biológicos y sistema de separación y análisis de fluidos biológicos
EP3085307B1 (de) 2013-04-15 2018-06-13 Becton, Dickinson and Company Entnahmevorrichtung für biologische flüssigkeit
EP2996789B1 (de) * 2013-05-17 2019-07-17 Siemens Healthcare Diagnostics Inc. Partikelfreisetzung und -sammlung
GB201319139D0 (en) * 2013-10-30 2013-12-11 Exmoor Pharma Concepts Ltd Apparatus and method for filtration of a suspension
IL247445B (en) 2014-02-26 2022-07-01 Brigham & Womens Hospital Inc System and method for gliding cells and monitoring
GB2525202A (en) * 2014-04-15 2015-10-21 Cells4Life Group Llp Methods of cell separation
US9901722B2 (en) 2014-06-01 2018-02-27 White Swell Medical Ltd System and method for treatment of pulmonary edema
CN106536059B (zh) 2014-06-09 2019-01-11 阿森特生物纳米科技股份有限公司 用于颗粒的控制和分拣系统
US10604751B2 (en) 2014-07-02 2020-03-31 Siemens Healthcare Disgnostics Inc. Selective nucleic acid separation
US10124275B2 (en) * 2014-09-05 2018-11-13 Imagine Tf, Llc Microstructure separation filters
US20160178490A1 (en) * 2014-12-22 2016-06-23 Saint-Gobain Performance Plastics Corporation Capture system of cells and methods
US20180120295A1 (en) * 2015-05-01 2018-05-03 Mesotex, Inc. Process for separating nucleated cells from non-nucleated red blood cells
EP3294369B1 (de) 2015-05-11 2021-09-01 White Swell Medical Ltd Systeme zur druckreduzierung an einem abfluss eines kanals
US9310328B1 (en) 2015-06-17 2016-04-12 King Abdulaziz University Method of detecting leukemia
US10925532B2 (en) 2015-08-06 2021-02-23 Becton, Dickinson And Company Biological fluid collection device and biological fluid collection system
US10976232B2 (en) 2015-08-24 2021-04-13 Gpb Scientific, Inc. Methods and devices for multi-step cell purification and concentration
US10859563B2 (en) * 2015-12-01 2020-12-08 General Electric Company Erythrocyte aggregation and leukocyte isolation
JP6256669B1 (ja) * 2016-03-18 2018-01-10 株式会社村田製作所 金属製多孔膜、それを用いた分級方法、および分級装置
JP6142042B1 (ja) * 2016-03-18 2017-06-07 株式会社村田製作所 有核細胞の濾過用フィルターおよびそれを用いた濾過方法
JP2017181096A (ja) * 2016-03-28 2017-10-05 日立化成株式会社 希少細胞を捕捉する方法
SG10202012275PA (en) 2016-06-09 2021-01-28 Haimachek Inc Collector for detection and reversible capturing of cells from body fluids in vivo
CA3042153A1 (en) 2016-11-01 2018-05-11 White Swell Medical Ltd Systems and methods for treatment of fluid overload
JP6234542B1 (ja) * 2016-12-27 2017-11-22 株式会社 ＴＬ Ｇｅｎｏｍｉｃｓ 胎児細胞由来染色体ｄｎａの取得方法
CA3054771A1 (en) 2017-03-02 2018-09-07 White Swell Medical Ltd Systems and methods for reducing pressure at an outflow of a duct
EP3600178B1 (de) 2017-03-19 2024-05-01 White Swell Medical Ltd Vorrichtungen zur druckreduzierung
WO2018191534A1 (en) * 2017-04-14 2018-10-18 Aviva Biosciences Corporation Methods, compositions, and devices for separating and/or enriching cells
TWI620597B (zh) * 2017-06-30 2018-04-11 創茂生技股份有限公司 聲波均質模組及生物樣本製備系統
CN107219360B (zh) * 2017-07-03 2018-04-03 南京岚煜生物科技有限公司 单通道化学发光微流控芯片及其检测方法
JP7209374B2 (ja) 2017-08-02 2023-01-20 ポカード・ディアグノスティクス・リミテッド フィルタを通して廃棄流体を除去するための方法および装置を含むプロセッサフィルタ配置
EP3675876A4 (de) 2017-09-01 2021-06-02 GPB Scientific, Inc. Verfahren zur herstellung therapeutisch aktiver zellen unter verwendung von mikrofluidik
WO2019078277A1 (ja) * 2017-10-19 2019-04-25 株式会社 ＴＬ Ｇｅｎｏｍｉｃｓ 細胞分級用チップ
US10758866B2 (en) 2017-11-30 2020-09-01 Wellsim Biomedical Technologies, Inc Isolation chip and manufacturing method of the same
CN109991410B (zh) * 2017-12-29 2022-07-05 上海白泽医学检验所有限公司 一种含抗cd45单抗的组合物及其使用方法
WO2019195934A1 (en) * 2018-04-10 2019-10-17 Xeinac Biotec Inc. Microfluidic chip
JP7133411B2 (ja) * 2018-09-19 2022-09-08 テルモ株式会社 Ｃｔｃ採取システム及びｃｔｃ採取システムの作動方法
US11793996B2 (en) 2019-02-26 2023-10-24 White Swell Medical Ltd Devices and methods for treating edema
US11660426B2 (en) 2019-02-26 2023-05-30 White Swell Medical Ltd Devices and methods for treating edema
US11931560B2 (en) 2019-02-26 2024-03-19 White Swell Medical Ltd Devices and methods for treating edema
US11724095B2 (en) 2019-02-26 2023-08-15 White Swell Medical Ltd Devices and methods for treating edema
US11717652B2 (en) 2019-02-26 2023-08-08 White Swell Medical Ltd Devices and methods for treating edema
US20210060229A1 (en) * 2019-09-04 2021-03-04 The Regents Of The University Of Michigan Office Of Technology Transfer Indwelling intravascular aphaeretic system for in vivo enrichment of circulating tumor cells
WO2021061525A1 (en) * 2019-09-25 2021-04-01 White Swell Medical Ltd Devices and methods for interstitial decongestion
CA3165491A1 (en) * 2020-01-27 2021-08-05 Damir KHISMATULLIN Apparatus, systems and methods for in vitro screening of complex biological fluids
CN111718836B (zh) * 2020-06-16 2022-08-26 东南大学 一种用于稀有细胞获取与单细胞封装的微流控芯片
CN116249884A (zh) * 2020-11-11 2023-06-09 深圳汇芯生物医疗科技有限公司 分离芯片组件
CN113462532B (zh) * 2021-05-28 2023-06-20 北京大学 细胞分离和富集一体化装置及方法
AU2022377625A1 (en) * 2021-10-28 2024-04-18 Southwest Research Institute Devices for cell separation

Family Cites Families (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1000038A (de) * 1960-12-06
US3635798A (en) * 1969-03-24 1972-01-18 William R Kirkham Blood and fluid culturing system
US4303422A (en) * 1980-05-22 1981-12-01 Fuel Inc. Fuel filter
US4797259A (en) * 1986-12-15 1989-01-10 Pall Corporation Well-type diagnostic plate device
GB2199946A (en) * 1987-01-12 1988-07-20 Pall Corp Diagnostic device,
US5237054A (en) * 1987-02-20 1993-08-17 Akzo Pharma Stabilized aqueous composition containing antibodies
EP0280358B1 (de) * 1987-02-20 1992-12-30 Akzo N.V. Antikörper enthaltende stabilisierte wässerige Zusammensetzung
DE3818860A1 (de) * 1988-06-03 1989-12-07 Seitz Filter Werke Filterelement
US5726026A (en) 1992-05-01 1998-03-10 Trustees Of The University Of Pennsylvania Mesoscale sample preparation device and systems for determination and processing of analytes
CA2087557C (en) * 1992-07-31 2000-04-25 Matthew Raskin Method for removing catalyst
US5275933A (en) 1992-09-25 1994-01-04 The Board Of Trustees Of The Leland Stanford Junior University Triple gradient process for recovering nucleated fetal cells from maternal blood
JP2943579B2 (ja) 1992-10-20 1999-08-30 三菱電機株式会社 磁気構造体並びにこれを用いた磁気ヘッドおよび磁気記録ヘッド
US5397479A (en) 1993-04-26 1995-03-14 International Remote Imaging Systems, Inc. Composition and method for enrichment of white blood cells from whole human blood
US5427663A (en) 1993-06-08 1995-06-27 British Technology Group Usa Inc. Microlithographic array for macromolecule and cell fractionation
US5626734A (en) 1995-08-18 1997-05-06 University Technologies International, Inc. Filter for perfusion cultures of animal cells and the like
DE19648881C2 (de) * 1996-11-26 1999-12-23 Geesthacht Gkss Forschung Polymermembran mit in der Membran lokalisierten Enzymen sowie Verfahren zur Herstellung von Erzeugnissen mittels in Polymermembranen ablaufender Reaktionen
US6139674A (en) * 1997-09-10 2000-10-31 Xerox Corporation Method of making an ink jet printhead filter by laser ablation
US6210889B1 (en) 1998-01-28 2001-04-03 The Universite Laval Method for enrichment of fetal cells from maternal blood and use of same in determination of fetal sex and detection of chromosomal abnormalities
CN1185492C (zh) 1999-03-15 2005-01-19 清华大学 可单点选通式微电磁单元阵列芯片、电磁生物芯片及应用
EP1309863A1 (de) 2000-08-08 2003-05-14 Aviva Biosciences Corporation Verfahren für biochemische mikrofluidmanipulationen
WO2002028523A2 (en) 2000-09-30 2002-04-11 Aviva Biosciences Corporation Apparatuses containing multiple force generating elements and uses thereof
CA2424996A1 (en) 2000-10-09 2002-04-18 Aviva Biosciences Corporation Compositions and methods for separation of moieties on chips
EP1328342A4 (de) 2000-10-10 2006-03-15 Aviva Biosciences Corp Integriertes biochipsystem zur probenherstellung und -analyse
WO2002031505A1 (en) 2000-10-10 2002-04-18 Aviva Biosciences Corporation Individually addressable micro-electromagnetic unit array chips in horizontal configurations

Also Published As

Publication number Publication date
EP2156879A2 (de) 2010-02-24
EP2156879A3 (de) 2010-07-07
AU2002334989A1 (en) 2003-04-22
DK1439897T3 (da) 2011-01-03
ATE479490T1 (de) 2010-09-15
EP1439897A2 (de) 2004-07-28
US6949355B2 (en) 2005-09-27
CA2462914A1 (en) 2003-04-17
US20030134416A1 (en) 2003-07-17
EP1439897B1 (de) 2010-09-01
WO2003031938A3 (en) 2003-11-13
WO2003031938A2 (en) 2003-04-17
EP1439897A4 (de) 2006-03-08

Similar Documents

Publication Publication Date Title
DE60237531D1 (de) Verfahren zum trennen von seltenen zellen von fluidproben
WO2006128192A3 (en) Use of free circulating dna for diagnosis, prognosis, and treatment of cancer
ATE240409T1 (de) Nicht-invasive pränatale diagnose
WO2007011412A3 (en) Diagnosis and prognosis of infectious diesease clinical phenotypes and other physiologic states using host gene expresion biomarkers in blood
ATE438737T1 (de) Verfahren für den nachweis von erkrankungen
ATE515575T1 (de) Verfahren und sonden für den nachweis von krebs
ATE275642T1 (de) Verfahren zur diagnose von krebs
WO2004069174A3 (en) Monitoring and treatment of amyotrophic lateral sclerosis
DK2332582T3 (da) ACE2-aktivering til behandling af hjerte-, lunge-og nyresygdomme samt forhøjet blodtryk
WO2004029285A3 (en) Methods for detecting endocrine cancer
DE60325382D1 (de) Verfahren zur diagnose von gebärmutterhalskrebs
ATE272214T1 (de) Verfahren zur diagnose von sepsis unter bestimmung von s100b
WO2003001183A3 (en) Methods for detecting and monitoring cox-2 rna in plasma and serum
WO2003048734A3 (en) Detection of matrix metalloproteinase rna in plasma and serum
CN104073499B (zh) Tmc1基因突变体及其应用
DE50105971D1 (de) Verfahren zur Diagnose von Sepsis unter Bestimmung von CA 125
ATE376595T1 (de) Nachweisverfahren mit biochip
HUP0401953A2 (hu) Biotinszármazékok
WO2001063293A3 (en) Diagnosis and treatment of schizophrenia
ATE429440T1 (de) Formen prostataspezifischer antigene und verfahren zu deren nachweis
WO2003104487A3 (en) DETECTION OF EPIGENETIC ABNORMALITIES AND DIAGNOSTIC METHOD BASED ON IT
SE9403953D0 (sv) Sequence-based diagnosis
DE60144027D1 (de) 5t4 rna in plasma und serum als marker für neoplastische erkrankungen
ATA19972000A (de) Pibf für die diagnose von tumoren
DE60309879D1 (de) Verfahren zur Diagnose von Krebs