DE60312309D1 - Verwendung von botulinum toxin zur behandlung von herz- und kreislaufskrankheiten - Google Patents
Verwendung von botulinum toxin zur behandlung von herz- und kreislaufskrankheitenInfo
- Publication number
- DE60312309D1 DE60312309D1 DE60312309T DE60312309T DE60312309D1 DE 60312309 D1 DE60312309 D1 DE 60312309D1 DE 60312309 T DE60312309 T DE 60312309T DE 60312309 T DE60312309 T DE 60312309T DE 60312309 D1 DE60312309 D1 DE 60312309D1
- Authority
- DE
- Germany
- Prior art keywords
- botulinum toxin
- treat heart
- diseases
- circular
- circular diseases
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/04—Macromolecular materials
- A61L31/043—Proteins; Polypeptides; Degradation products thereof
- A61L31/047—Other specific proteins or polypeptides not covered by A61L31/044 - A61L31/046
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
- A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
- A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
- A61K38/4886—Metalloendopeptidases (3.4.24), e.g. collagenase
- A61K38/4893—Botulinum neurotoxin (3.4.24.69)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/08—Clostridium, e.g. Clostridium tetani
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US114740 | 1980-01-24 | ||
US10/114,740 US6767544B2 (en) | 2002-04-01 | 2002-04-01 | Methods for treating cardiovascular diseases with botulinum toxin |
PCT/US2003/009157 WO2003084567A1 (en) | 2002-04-01 | 2003-03-24 | Use of botulinum toxin for treating cardiovasular diseases |
Publications (3)
Publication Number | Publication Date |
---|---|
DE60312309D1 true DE60312309D1 (de) | 2007-04-19 |
DE60312309T2 DE60312309T2 (de) | 2007-11-08 |
DE60312309T3 DE60312309T3 (de) | 2011-02-24 |
Family
ID=28453838
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE60312309T Expired - Lifetime DE60312309T3 (de) | 2002-04-01 | 2003-03-24 | Verwendung von botulinum toxin zur behandlung von herz- und kreislaufskrankheiten |
Country Status (13)
Country | Link |
---|---|
US (4) | US6767544B2 (de) |
EP (1) | EP1490097B2 (de) |
JP (3) | JP2005521735A (de) |
KR (1) | KR20040105818A (de) |
AT (1) | ATE355852T1 (de) |
AU (1) | AU2003220511C1 (de) |
BR (1) | BR0308928A (de) |
CA (1) | CA2480505A1 (de) |
DE (1) | DE60312309T3 (de) |
ES (1) | ES2281636T5 (de) |
HK (1) | HK1070575A1 (de) |
MX (1) | MXPA04009410A (de) |
WO (1) | WO2003084567A1 (de) |
Families Citing this family (60)
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US6767544B2 (en) * | 2002-04-01 | 2004-07-27 | Allergan, Inc. | Methods for treating cardiovascular diseases with botulinum toxin |
US6579847B1 (en) * | 2000-05-01 | 2003-06-17 | Imarx Therapeutics Inc. | Method and apparatus for vascular neuromuscular blockade |
WO2003059192A2 (en) | 2001-12-21 | 2003-07-24 | The Trustees Of Columbia University In The City Of New York | C3 exoenzyme-coated stents and uses thereof for treating and preventing restenosis |
US7022329B2 (en) * | 2002-02-25 | 2006-04-04 | Allergan, Inc. | Method for treating neurogenic inflammation pain with botulinum toxin and substance P components |
US6978174B2 (en) | 2002-04-08 | 2005-12-20 | Ardian, Inc. | Methods and devices for renal nerve blocking |
US7617005B2 (en) | 2002-04-08 | 2009-11-10 | Ardian, Inc. | Methods and apparatus for thermally-induced renal neuromodulation |
US20070135875A1 (en) | 2002-04-08 | 2007-06-14 | Ardian, Inc. | Methods and apparatus for thermally-induced renal neuromodulation |
US8150519B2 (en) | 2002-04-08 | 2012-04-03 | Ardian, Inc. | Methods and apparatus for bilateral renal neuromodulation |
US7653438B2 (en) | 2002-04-08 | 2010-01-26 | Ardian, Inc. | Methods and apparatus for renal neuromodulation |
US20080213331A1 (en) | 2002-04-08 | 2008-09-04 | Ardian, Inc. | Methods and devices for renal nerve blocking |
US9636174B2 (en) | 2002-04-08 | 2017-05-02 | Medtronic Ardian Luxembourg S.A.R.L. | Methods for therapeutic renal neuromodulation |
US20070129761A1 (en) | 2002-04-08 | 2007-06-07 | Ardian, Inc. | Methods for treating heart arrhythmia |
AU2003259246A1 (en) * | 2002-07-29 | 2004-02-16 | Rajiv Doshi | Methods for the use of neurotoxin in the treatment of urologic disorders |
US20040226556A1 (en) | 2003-05-13 | 2004-11-18 | Deem Mark E. | Apparatus for treating asthma using neurotoxin |
US8073538B2 (en) | 2003-11-13 | 2011-12-06 | Cardio Polymers, Inc. | Treatment of cardiac arrhythmia by modification of neuronal signaling through fat pads of the heart |
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US7514088B2 (en) * | 2005-03-15 | 2009-04-07 | Allergan, Inc. | Multivalent Clostridial toxin derivatives and methods of their use |
US20060024331A1 (en) * | 2004-08-02 | 2006-02-02 | Ester Fernandez-Salas | Toxin compounds with enhanced membrane translocation characteristics |
JP5089388B2 (ja) | 2004-09-01 | 2012-12-05 | アラーガン、インコーポレイテッド | 分解可能なクロストリジウム毒素 |
US7906124B2 (en) * | 2004-09-18 | 2011-03-15 | Asthmatx, Inc. | Inactivation of smooth muscle tissue |
GB2419817A (en) * | 2004-10-29 | 2006-05-10 | Ipsen Ltd | Treatment of cardiac fibrillation disorders |
CN101076290B (zh) | 2004-12-09 | 2011-11-23 | 铸造品股份有限公司 | 主动脉瓣修复 |
US9833618B2 (en) * | 2005-02-04 | 2017-12-05 | Palo Alto Investors | Methods and compositions for treating a disease condition in a subject |
WO2006101809A1 (en) | 2005-03-15 | 2006-09-28 | Allergan, Inc. | Modified clostridial toxins with enhanced targeting capabilities for endogenous clostridial toxin receptor systems |
DE602006017237D1 (en) | 2005-04-05 | 2010-11-11 | Allergan Inc | Clostridientoxinaktivitätstests |
US9511210B2 (en) | 2006-05-19 | 2016-12-06 | The Foundry, Llc | Apparatus for toxin delivery to the nasal cavity |
WO2007014003A2 (en) | 2005-07-22 | 2007-02-01 | The Foundry Inc. | Systems and methods for delivery of a therapeutic agent |
US10052465B2 (en) | 2005-07-22 | 2018-08-21 | The Foundry, Llc | Methods and systems for toxin delivery to the nasal cavity |
US7794386B2 (en) | 2006-03-15 | 2010-09-14 | Allergan, Inc. | Methods for facilitating weight loss |
US20070237802A1 (en) * | 2006-04-11 | 2007-10-11 | Medtronic Vascular, Inc. | Inhibition of Calcification on an Endovascular Device |
US20080092910A1 (en) * | 2006-10-18 | 2008-04-24 | Allergan, Inc. | Apparatus and method for treating obesity using neurotoxins in conjunction with bariatric procedures |
US8483831B1 (en) | 2008-02-15 | 2013-07-09 | Holaira, Inc. | System and method for bronchial dilation |
US8470337B2 (en) * | 2008-03-13 | 2013-06-25 | Allergan, Inc. | Therapeutic treatments using botulinum neurotoxin |
CN102014779B (zh) | 2008-05-09 | 2014-10-22 | 赫莱拉公司 | 用于治疗支气管树的系统、组件和方法 |
WO2010101968A1 (en) | 2009-03-06 | 2010-09-10 | Allergan, Inc. | Clostridial toxin to improve ejaculate |
EP2482838A4 (de) * | 2009-09-30 | 2013-04-10 | Toxcure Inc | Verwendung von botulinum-neurotoxin zur behandlung von substanzabhängigkeit |
CN112089394A (zh) | 2009-10-27 | 2020-12-18 | 努瓦拉公司 | 具有可冷却的能量发射组件的递送装置 |
WO2011060200A1 (en) | 2009-11-11 | 2011-05-19 | Innovative Pulmonary Solutions, Inc. | Systems, apparatuses, and methods for treating tissue and controlling stenosis |
US8911439B2 (en) | 2009-11-11 | 2014-12-16 | Holaira, Inc. | Non-invasive and minimally invasive denervation methods and systems for performing the same |
EP2563459A1 (de) | 2010-04-30 | 2013-03-06 | Boston Scientific Scimed, Inc. | Freisetzungsvorrichtung für ein therapeutikum zur freisetzung eines neurotoxins |
US20120207743A1 (en) * | 2011-02-14 | 2012-08-16 | Allergan, Inc. | Inhibiting Aberrant Blood Vessel Formation Using Retargeted Endopeptidases |
EP2694150A1 (de) | 2011-04-08 | 2014-02-12 | Covidien LP | Iontophorese-medikamentenabgabesystem sowie verfahren zur denervierung der renalen sympathischen nerven und iontophorese-medikamentenabgabe |
US9005628B2 (en) | 2012-10-04 | 2015-04-14 | Dublin City University | Biotherapy for pain |
US9398933B2 (en) | 2012-12-27 | 2016-07-26 | Holaira, Inc. | Methods for improving drug efficacy including a combination of drug administration and nerve modulation |
GB201312317D0 (en) | 2013-07-09 | 2013-08-21 | Syntaxin Ltd | Cationic neurotoxins |
US10149893B2 (en) | 2013-09-24 | 2018-12-11 | Allergan, Inc. | Methods for modifying progression of osteoarthritis |
US9216210B2 (en) | 2013-12-23 | 2015-12-22 | Dublin City University | Multiprotease therapeutics for chronic pain |
US20170246268A1 (en) * | 2014-09-12 | 2017-08-31 | Gary E.l BORODIC | Longevity Enhancement Induced by Repetitive Injections of Botulinum Toxin (Centurion Effect) |
PL3242884T3 (pl) | 2015-01-09 | 2021-08-16 | Ipsen Bioinnovation Limited | Kationowe neurotoksyny |
GB201517450D0 (en) | 2015-10-02 | 2015-11-18 | Ipsen Biopharm Ltd | Method |
GB201607901D0 (en) | 2016-05-05 | 2016-06-22 | Ipsen Biopharm Ltd | Chimeric neurotoxins |
EP3263710A1 (de) | 2016-07-01 | 2018-01-03 | Ipsen Biopharm Limited | Herstellung von aktivierten clostridien-neurotoxinen |
CN109790204A (zh) | 2016-09-29 | 2019-05-21 | 益普生生物制药有限公司 | 杂合神经毒素 |
US11116561B2 (en) | 2018-01-24 | 2021-09-14 | Medtronic Ardian Luxembourg S.A.R.L. | Devices, agents, and associated methods for selective modulation of renal nerves |
WO2019162696A1 (en) | 2018-02-26 | 2019-08-29 | Ipsen Biopharm Limited | Use of ultrasound to guide injection of non-cytotoxic protease |
GB202103372D0 (en) | 2021-03-11 | 2021-04-28 | Ipsen Biopharm Ltd | Modified clostridial neurotoxins |
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-
2002
- 2002-04-01 US US10/114,740 patent/US6767544B2/en not_active Expired - Fee Related
-
2003
- 2003-03-24 WO PCT/US2003/009157 patent/WO2003084567A1/en active IP Right Grant
- 2003-03-24 JP JP2003581806A patent/JP2005521735A/ja not_active Withdrawn
- 2003-03-24 ES ES03716821T patent/ES2281636T5/es not_active Expired - Lifetime
- 2003-03-24 BR BR0308928-2A patent/BR0308928A/pt not_active IP Right Cessation
- 2003-03-24 AT AT03716821T patent/ATE355852T1/de not_active IP Right Cessation
- 2003-03-24 KR KR10-2004-7015481A patent/KR20040105818A/ko not_active Application Discontinuation
- 2003-03-24 EP EP03716821A patent/EP1490097B2/de not_active Expired - Lifetime
- 2003-03-24 CA CA002480505A patent/CA2480505A1/en not_active Abandoned
- 2003-03-24 MX MXPA04009410A patent/MXPA04009410A/es active IP Right Grant
- 2003-03-24 AU AU2003220511A patent/AU2003220511C1/en not_active Ceased
- 2003-03-24 DE DE60312309T patent/DE60312309T3/de not_active Expired - Lifetime
- 2003-07-28 US US10/628,905 patent/US7048927B2/en not_active Expired - Fee Related
-
2004
- 2004-06-16 US US10/870,603 patent/US7494654B2/en not_active Expired - Fee Related
-
2005
- 2005-04-15 HK HK05103242A patent/HK1070575A1/xx not_active IP Right Cessation
-
2006
- 2006-02-01 US US11/345,736 patent/US7223399B2/en not_active Expired - Fee Related
-
2009
- 2009-02-16 JP JP2009032291A patent/JP2009102440A/ja not_active Withdrawn
-
2012
- 2012-12-19 JP JP2012277214A patent/JP2013053167A/ja not_active Withdrawn
Also Published As
Publication number | Publication date |
---|---|
US20040142005A1 (en) | 2004-07-22 |
AU2003220511B2 (en) | 2006-11-16 |
ATE355852T1 (de) | 2007-03-15 |
US20030185860A1 (en) | 2003-10-02 |
US6767544B2 (en) | 2004-07-27 |
MXPA04009410A (es) | 2005-01-25 |
WO2003084567A1 (en) | 2003-10-16 |
HK1070575A1 (en) | 2005-06-24 |
US7223399B2 (en) | 2007-05-29 |
US20060127417A1 (en) | 2006-06-15 |
US7494654B2 (en) | 2009-02-24 |
JP2009102440A (ja) | 2009-05-14 |
KR20040105818A (ko) | 2004-12-16 |
US7048927B2 (en) | 2006-05-23 |
JP2013053167A (ja) | 2013-03-21 |
EP1490097B2 (de) | 2010-08-18 |
ES2281636T5 (es) | 2010-12-17 |
US20040223975A1 (en) | 2004-11-11 |
JP2005521735A (ja) | 2005-07-21 |
EP1490097A1 (de) | 2004-12-29 |
DE60312309T3 (de) | 2011-02-24 |
BR0308928A (pt) | 2005-01-04 |
EP1490097B1 (de) | 2007-03-07 |
ES2281636T3 (es) | 2007-10-01 |
AU2003220511C1 (en) | 2008-03-06 |
DE60312309T2 (de) | 2007-11-08 |
AU2003220511A1 (en) | 2003-10-20 |
CA2480505A1 (en) | 2003-10-16 |
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