DE60318388D1 - Verfahren und zusammensetzungen zum sauerstofftransport mit hoher sauerstoffaffinität - Google Patents
Verfahren und zusammensetzungen zum sauerstofftransport mit hoher sauerstoffaffinitätInfo
- Publication number
- DE60318388D1 DE60318388D1 DE60318388T DE60318388T DE60318388D1 DE 60318388 D1 DE60318388 D1 DE 60318388D1 DE 60318388 T DE60318388 T DE 60318388T DE 60318388 T DE60318388 T DE 60318388T DE 60318388 D1 DE60318388 D1 DE 60318388D1
- Authority
- DE
- Germany
- Prior art keywords
- oxygen
- compositions
- factility
- transportation
- present
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 title abstract 4
- 239000000203 mixture Substances 0.000 title abstract 4
- 229910052760 oxygen Inorganic materials 0.000 title abstract 4
- 239000001301 oxygen Substances 0.000 title abstract 4
- 102000001554 Hemoglobins Human genes 0.000 abstract 1
- 108010054147 Hemoglobins Proteins 0.000 abstract 1
- 239000010836 blood and blood product Substances 0.000 abstract 1
- 229940125691 blood product Drugs 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/14—Blood; Artificial blood
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/41—Porphyrin- or corrin-ring-containing peptides
- A61K38/42—Haemoglobins; Myoglobins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
- A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/06—Antianaemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/08—Plasma substitutes; Perfusion solutions; Dialytics or haemodialytics; Drugs for electrolytic or acid-base disorders, e.g. hypovolemic shock
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US34774102P | 2002-01-11 | 2002-01-11 | |
| US347741P | 2002-01-11 | ||
| US10/114,400 US20030153491A1 (en) | 2002-01-11 | 2002-04-01 | Methods and compositions for oxygen transport comprising a high oxygen affinity modified hemoglobin |
| US114400 | 2002-04-01 | ||
| PCT/US2003/000696 WO2003059363A1 (en) | 2002-01-11 | 2003-01-10 | Methods and compositions for oxygen transport comprising a high oyzgen affinity |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE60318388D1 true DE60318388D1 (de) | 2008-02-14 |
| DE60318388T2 DE60318388T2 (de) | 2008-12-24 |
Family
ID=26812138
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE60318388T Expired - Lifetime DE60318388T2 (de) | 2002-01-11 | 2003-01-10 | Verfahren und zusammensetzungen zum sauerstofftransport mit hoher sauerstoffaffinität |
Country Status (15)
| Country | Link |
|---|---|
| US (3) | US20030153491A1 (de) |
| EP (1) | EP1465643B1 (de) |
| JP (2) | JP5149480B2 (de) |
| KR (1) | KR100964604B1 (de) |
| CN (2) | CN1630527B (de) |
| AT (1) | ATE382358T1 (de) |
| AU (1) | AU2003207504B2 (de) |
| BR (1) | BR0306846A (de) |
| CA (1) | CA2473662C (de) |
| DE (1) | DE60318388T2 (de) |
| DK (1) | DK1465643T3 (de) |
| ES (1) | ES2299686T3 (de) |
| MX (1) | MXPA04006733A (de) |
| PT (1) | PT1465643E (de) |
| WO (1) | WO2003059363A1 (de) |
Families Citing this family (50)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2001062827A2 (en) | 2000-02-22 | 2001-08-30 | Shearwater Corporation | N-maleimidyl polymer derivatives |
| US20050164915A1 (en) * | 2002-04-01 | 2005-07-28 | Sangart, Inc. | Compositions for oxygen transport comprising a high oxygen affinity modified hemoglobin |
| EP1585538B1 (de) * | 2002-12-23 | 2011-02-09 | Albert Einstein College Of Medicine Of Yeshiva University | Nicht-hypertensive pegylierte hämoglobine und deren herstellungsverfahren |
| US7432331B2 (en) | 2002-12-31 | 2008-10-07 | Nektar Therapeutics Al, Corporation | Hydrolytically stable maleimide-terminated polymers |
| AU2003300133B2 (en) * | 2002-12-31 | 2008-11-13 | Nektar Therapeutics | Hydrolytically stable maleimide-terminated polymers |
| US7790835B2 (en) | 2003-12-03 | 2010-09-07 | Nektar Therapeutics | Method of preparing maleimide functionalized polymers |
| WO2006026739A2 (en) * | 2004-08-31 | 2006-03-09 | Sangart, Inc. | Methods to enhance hemodynamic stability using oxygen carrying compositions |
| US8455437B2 (en) * | 2005-02-04 | 2013-06-04 | The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services | Method to predict and prevent oxygen-induced inflammatory tissue injury |
| EP1863503B1 (de) * | 2005-03-07 | 2019-05-22 | Sangart, Inc. | Zusammensetzung zur abgabe von kohlenmonoxid (co) und stickoxid (no) an gewebe unter verwendung von heme-proteinen als träger |
| WO2007050121A2 (en) * | 2005-05-11 | 2007-05-03 | Albert Einstein College Of Medicine Of Yeshiva University | Site specific pegylated hemoglobin, method of preparing same, and uses thereof |
| US8741832B2 (en) * | 2005-06-10 | 2014-06-03 | Albert Einstein College Of Medicine Of Yeshiva University | Pegylated albumin and uses thereof |
| WO2007058678A2 (en) * | 2005-06-10 | 2007-05-24 | Albert Einstein College Of Medicine Of Yeshiva University | Uses of pegylated albumin |
| KR101334541B1 (ko) * | 2005-07-19 | 2013-11-28 | 넥타르 테라퓨틱스 | 중합체 말레이미드를 제조하는 방법 |
| EP2474554A3 (de) | 2006-05-22 | 2012-10-03 | The Regents of The University of California | Zusammensetzungen und Verfahren zur Freisetzung von Sauerstoff |
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| LT2440239T (lt) | 2009-06-09 | 2017-12-11 | Prolong Pharmaceuticals, LLC | Hemoglobino kompozicijos |
| US10172949B2 (en) | 2009-06-09 | 2019-01-08 | Prolong Pharmaceuticals, LLC | Hemoglobin compositions |
| US10172950B2 (en) | 2009-06-09 | 2019-01-08 | Prolong Pharmaceuticals, LLC | Hemoglobin compositions |
| US9114109B2 (en) * | 2009-06-16 | 2015-08-25 | University of Pittsburgh—of the Commonwealth System of Higher Education | Five-coordinate neuroglobin and use thereof as a blood substitute |
| US8273857B2 (en) * | 2009-09-22 | 2012-09-25 | Jen-Chang Hsia | Compositions and methods of use of neurovascular protective multifunctional polynitroxylated pegylated carboxy hemoglobins for transfusion and critical care medicine |
| US20130041134A1 (en) * | 2009-11-05 | 2013-02-14 | Sangart ,Inc. | Methods for preparing polyethylene glycol maleimide using n-(2-hydroxyethyl) maleimide as a starting material |
| CN102859364A (zh) * | 2010-02-25 | 2013-01-02 | 桑格特公司 | 通过减少反应物比例制备聚乙二醇-血红蛋白缀合物的方法 |
| US7989593B1 (en) | 2010-05-27 | 2011-08-02 | Bing Lou Wong | Method for the preparation of a high-temperature stable oxygen-carrier-containing pharmaceutical composition and the use thereof |
| US8048856B1 (en) | 2010-06-23 | 2011-11-01 | Billion King, Ltd. | Treatment methods using a heat stable oxygen carrier-containing pharmaceutical composition |
| US7932356B1 (en) | 2010-06-23 | 2011-04-26 | Bing Lou Wong | Method for the preparation of a heat stable oxygen carrier-containing pharmaceutical composition |
| ES2718308T3 (es) * | 2011-01-07 | 2019-07-01 | Poseida Therapeutics Inc | Composiciones y métodos para la administración a tumores de agentes de unión de alta afinidad al oxígeno |
| US20120196270A1 (en) * | 2011-02-02 | 2012-08-02 | Sangart, Inc. | Methods for preserving an organ for transplantation using a hemoglobin-carbon monoxide complex |
| JP6083674B2 (ja) | 2011-03-01 | 2017-02-22 | 学校法人 中央大学 | ヘモグロビン−アルブミン複合体、並びに該複合体を含む人工血漿増量剤及び人工酸素運搬体 |
| US8084581B1 (en) | 2011-04-29 | 2011-12-27 | Bing Lou Wong | Method for removing unmodified hemoglobin from cross-linked hemoglobin solutions including polymeric hemoglobin with a high temperature short time heat treatment apparatus |
| US20130052232A1 (en) | 2011-08-31 | 2013-02-28 | Bing Lou Wong | Method for the preparation of a heat stable oxygen carrier-containing composition facilating beta-beta cross-linking |
| WO2013070592A1 (en) * | 2011-11-07 | 2013-05-16 | The General Hospital Corporation | Treatment of red blood cells |
| EP2830638B1 (de) * | 2012-03-29 | 2021-05-05 | Schindler, William | Diaspirinvernetztes pegyliertes hämoglobin |
| JP2015514718A (ja) | 2012-04-03 | 2015-05-21 | サンガート， インコーポレイテッド | スクシンイミド活性化されたニトロキシル化合物およびタンパク質のニトロキシル化のためのその使用のための方法 |
| WO2013151682A1 (en) | 2012-04-06 | 2013-10-10 | Children's Medical Center Corporation | Process for forming microbubbles with high oxygen content and uses thereof |
| CA2897018C (en) | 2013-01-07 | 2021-07-27 | Omniox, Inc. | Polymeric forms of h-nox proteins |
| WO2014145755A1 (en) | 2013-03-15 | 2014-09-18 | Sangart, Inc. | Polyalkylene oxide valerate hemoglobin conjugates |
| WO2014144364A1 (en) | 2013-03-15 | 2014-09-18 | Children's Medical Center Corporation | Gas-filled stabilized particles and methods of use |
| US10456452B2 (en) | 2015-07-02 | 2019-10-29 | Poseida Therapeutics, Inc. | Compositions and methods for improved encapsulation of functional proteins in polymeric vesicles |
| CN105497894B (zh) * | 2015-12-21 | 2019-01-04 | 中国科学院深圳先进技术研究院 | 用于肿瘤光动力治疗的血红蛋白-光敏剂试剂及其应用 |
| WO2017143104A1 (en) | 2016-02-16 | 2017-08-24 | Omniox, Inc. | Modulation hypoxia associated with stroke |
| US11213594B2 (en) | 2016-04-29 | 2022-01-04 | Poseida Therapeutics, Inc. | Poly(histidine)-based micelles for complexation and delivery of proteins and nucleic acids |
| WO2018008729A1 (ja) | 2016-07-06 | 2018-01-11 | 学校法人 中央大学 | 虚血性疾患の治療剤 |
| ES2651717B1 (es) * | 2016-07-26 | 2018-11-16 | Lara OLLER DUQUE | Solución acuosa cristaloide isotónica |
| US11147890B2 (en) | 2017-02-28 | 2021-10-19 | Children's Medical Center Corporation | Stimuli-responsive particles encapsulating a gas and methods of use |
| WO2020037052A1 (en) | 2018-08-15 | 2020-02-20 | Omniox, Inc. | H-nox proteins for treating cardiovascular and pulmonary conditions |
| CN111499732B (zh) * | 2020-04-22 | 2022-05-13 | 中国科学院过程工程研究所 | 一种基于双重化学修饰的血红蛋白氧载体及其制备方法和应用 |
| WO2021261712A1 (en) * | 2020-06-26 | 2021-12-30 | Sunbio, Inc. | Hemoglobin derivative co-conjugated with fatty acid-linked peg and alkoxy peg as a blood substitute |
| CN114617957B (zh) * | 2022-03-10 | 2024-01-16 | 中国人民解放军军事科学院军事医学研究院 | 羟乙基淀粉血红蛋白偶联物及其制备方法与应用 |
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-
2002
- 2002-04-01 US US10/114,400 patent/US20030153491A1/en not_active Abandoned
-
2003
- 2003-01-10 DE DE60318388T patent/DE60318388T2/de not_active Expired - Lifetime
- 2003-01-10 CN CN038036487A patent/CN1630527B/zh not_active Expired - Fee Related
- 2003-01-10 AT AT03705713T patent/ATE382358T1/de active
- 2003-01-10 JP JP2003559525A patent/JP5149480B2/ja not_active Expired - Fee Related
- 2003-01-10 BR BR0306846-3A patent/BR0306846A/pt not_active Application Discontinuation
- 2003-01-10 US US10/340,141 patent/US6844317B2/en not_active Expired - Lifetime
- 2003-01-10 WO PCT/US2003/000696 patent/WO2003059363A1/en active IP Right Grant
- 2003-01-10 KR KR1020047010847A patent/KR100964604B1/ko active IP Right Grant
- 2003-01-10 ES ES03705713T patent/ES2299686T3/es not_active Expired - Lifetime
- 2003-01-10 DK DK03705713T patent/DK1465643T3/da active
- 2003-01-10 CN CN2013100910214A patent/CN103203013A/zh active Pending
- 2003-01-10 MX MXPA04006733A patent/MXPA04006733A/es active IP Right Grant
- 2003-01-10 EP EP03705713A patent/EP1465643B1/de not_active Expired - Lifetime
- 2003-01-10 AU AU2003207504A patent/AU2003207504B2/en not_active Ceased
- 2003-01-10 CA CA002473662A patent/CA2473662C/en not_active Expired - Lifetime
- 2003-01-10 PT PT03705713T patent/PT1465643E/pt unknown
-
2004
- 2004-08-24 US US10/925,067 patent/US6974795B2/en not_active Expired - Lifetime
-
2010
- 2010-03-09 JP JP2010052387A patent/JP2010138197A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| US20030153491A1 (en) | 2003-08-14 |
| US20050026816A1 (en) | 2005-02-03 |
| CA2473662C (en) | 2009-12-22 |
| JP5149480B2 (ja) | 2013-02-20 |
| EP1465643B1 (de) | 2008-01-02 |
| KR20040081451A (ko) | 2004-09-21 |
| US6974795B2 (en) | 2005-12-13 |
| KR100964604B1 (ko) | 2010-06-21 |
| JP2005515225A (ja) | 2005-05-26 |
| CN1630527A (zh) | 2005-06-22 |
| BR0306846A (pt) | 2004-12-07 |
| PT1465643E (pt) | 2008-03-27 |
| DE60318388T2 (de) | 2008-12-24 |
| ES2299686T3 (es) | 2008-06-01 |
| AU2003207504A1 (en) | 2003-07-30 |
| CN1630527B (zh) | 2013-04-24 |
| JP2010138197A (ja) | 2010-06-24 |
| ATE382358T1 (de) | 2008-01-15 |
| DK1465643T3 (da) | 2008-05-13 |
| WO2003059363A1 (en) | 2003-07-24 |
| US6844317B2 (en) | 2005-01-18 |
| CN103203013A (zh) | 2013-07-17 |
| EP1465643A4 (de) | 2004-10-20 |
| AU2003207504B2 (en) | 2007-05-24 |
| EP1465643A1 (de) | 2004-10-13 |
| US20030162693A1 (en) | 2003-08-28 |
| MXPA04006733A (es) | 2005-12-05 |
| CA2473662A1 (en) | 2003-07-24 |
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