DE60324155D1 - Indol-3-carbinol metaboliten als chemotherapeutische und chemopräventive wirkstoffen - Google Patents

Indol-3-carbinol metaboliten als chemotherapeutische und chemopräventive wirkstoffen

Info

Publication number
DE60324155D1
DE60324155D1 DE60324155T DE60324155T DE60324155D1 DE 60324155 D1 DE60324155 D1 DE 60324155D1 DE 60324155 T DE60324155 T DE 60324155T DE 60324155 T DE60324155 T DE 60324155T DE 60324155 D1 DE60324155 D1 DE 60324155D1
Authority
DE
Germany
Prior art keywords
compounds
carbinol
chemotherapeutic
metabolites
agents
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60324155T
Other languages
English (en)
Inventor
Ling Jong
Wan-Ru Chao
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
SRI International Inc
Original Assignee
SRI International Inc
Stanford Research Institute
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by SRI International Inc, Stanford Research Institute filed Critical SRI International Inc
Application granted granted Critical
Publication of DE60324155D1 publication Critical patent/DE60324155D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/30—Oestrogens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/32—Antioestrogens
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
DE60324155T 2002-08-20 2003-08-15 Indol-3-carbinol metaboliten als chemotherapeutische und chemopräventive wirkstoffen Expired - Lifetime DE60324155D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US10/224,979 US6800655B2 (en) 2002-08-20 2002-08-20 Analogs of indole-3-carbinol metabolites as chemotherapeutic and chemopreventive agents
PCT/US2003/025772 WO2004018475A2 (en) 2002-08-20 2003-08-15 Analogs of indole-3-carbinol metabolites as chemotherapeutic and chemopreventive agents

Publications (1)

Publication Number Publication Date
DE60324155D1 true DE60324155D1 (de) 2008-11-27

Family

ID=31946289

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60324155T Expired - Lifetime DE60324155D1 (de) 2002-08-20 2003-08-15 Indol-3-carbinol metaboliten als chemotherapeutische und chemopräventive wirkstoffen

Country Status (8)

Country Link
US (4) US6800655B2 (de)
EP (2) EP1623985B1 (de)
JP (3) JP4764629B2 (de)
AT (1) ATE411317T1 (de)
AU (1) AU2003263878A1 (de)
CA (1) CA2496203C (de)
DE (1) DE60324155D1 (de)
WO (1) WO2004018475A2 (de)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
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US6800655B2 (en) * 2002-08-20 2004-10-05 Sri International Analogs of indole-3-carbinol metabolites as chemotherapeutic and chemopreventive agents
BRPI0510717B8 (pt) * 2004-05-06 2021-05-25 Bioresponse Llc uso de 3,3' diindolilmetano (dim) ou 2-(indol-3-ilmetil)-3,3´-diindolilmetano (ltr)
US20060100264A1 (en) * 2004-11-06 2006-05-11 Bjeldanes Leonard F 3,3'-Diindolylmethane immune activating compositions
WO2006083458A2 (en) 2004-12-30 2006-08-10 Bioresponse Llc Use of diindolylmethane-related indoles for the treatment and prevention of respiratory syncytial virus associates conditions
US20080161251A1 (en) 2005-01-21 2008-07-03 Astex Therapeutics Limited Pharmaceutical Compounds
WO2006125324A1 (en) 2005-05-27 2006-11-30 Queen's University At Kingston Treatment of protein folding disorders
CN1807413B (zh) * 2005-09-28 2010-05-05 中国医学科学院医药生物技术研究所 咔唑磺酰胺衍生物及其制备方法
CN102643248A (zh) 2006-04-18 2012-08-22 日本化学医药株式会社 过氧化物酶体增殖剂激活受体δ的激活剂
US8916552B2 (en) 2006-10-12 2014-12-23 Astex Therapeutics Limited Pharmaceutical combinations
EP2073807A1 (de) 2006-10-12 2009-07-01 Astex Therapeutics Limited Pharmazeutische kombinationen
WO2008057253A2 (en) 2006-10-27 2008-05-15 Bioresponse, L.L.C. Anti-parasitic methods and compositions utilizing diindolylmethane-related indoles
US7807705B2 (en) * 2007-05-18 2010-10-05 The Ohio State University Research Foundation Potent indole-3-carbinol-derived antitumor agents
WO2009012096A2 (en) * 2007-07-18 2009-01-22 Research Development Foundation Improved therapeutic methods and compositions comprising chroman ring compounds
CN104672220B (zh) 2008-04-15 2017-09-22 日本化学医药株式会社 过氧化物酶体增殖剂活化受体的活化剂
EP2326327B1 (de) * 2008-09-17 2016-03-23 SRI International Analoge von indol-3-carbinol und ihre verwendung als mittel gegen entzündungen
KR101477613B1 (ko) * 2009-03-31 2014-12-30 롬엔드하스전자재료코리아유한회사 신규한 유기 전자재료용 화합물 및 이를 포함하는 유기 전자 소자
US20120184590A1 (en) * 2009-04-09 2012-07-19 University Of Kansas Formulations of indole-3-carbinol derived antitumor agents with increased oral bioavailability
EP2464349A2 (de) * 2009-08-14 2012-06-20 Cerenis Therapeutics S.A. Verwendung von ppar-delta-liganden für die behandlung oder prävention von entzündungen oder energiestoffwechsel-/produktionsbedingten erkrankungen
US8153680B2 (en) * 2009-08-25 2012-04-10 The Ohio State University Research Foundation Alkyl indole-3-carbinol-derived antitumor agents
DE102009052428A1 (de) * 2009-11-10 2011-05-12 Merck Patent Gmbh Verbindung für elektronische Vorrichtungen
US20130059850A1 (en) * 2010-05-06 2013-03-07 Merck Sharp & Dohme Corp. Aza-indole derivatives useful as modulators of faah
CA2827214C (en) 2011-04-01 2017-07-18 Sri International Lipoxygenase inhibitors
WO2015042170A1 (en) 2013-09-17 2015-03-26 Wayne State University Compositions and uses of combinations of dim-related indoles and selected anti-androgen compounds
CN104030964B (zh) * 2014-06-05 2016-06-29 天津科技大学 双吲哚类化合物及合成方法
US9969686B2 (en) * 2014-08-05 2018-05-15 Wisconsin Alumni Research Foundation Synthesis of diindolylmethanes and indolo[3,2-b]carbazoles, compounds formed thereby, and pharmaceutical compositions containing them
WO2016164770A1 (en) 2015-04-10 2016-10-13 Bioresponse, L.L.C. Self-emulsifying formulations of dim-related indoles
CA3030582A1 (en) 2015-07-22 2017-01-26 The Royal Institution For The Advancement Of Learning/Mcgill University Compounds and uses thereof in the treatment of cancers and other medical conditions
CN105218552B (zh) * 2015-09-30 2018-02-27 中国人民解放军军事医学科学院野战输血研究所 一种取代苯基二氢吲哚咔唑衍生物及其制备方法与应用
CN110698654B (zh) * 2018-07-10 2021-04-02 中国科学院长春应用化学研究所 基于三聚吲哚的超支化共轭聚电解质及其制备方法和用途

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US4636820A (en) * 1980-03-06 1987-01-13 The Hilton-Davis Chemical Compositions, process and systems
DE3752344D1 (de) * 1986-10-28 2002-01-17 Ciba Sc Holding Ag Chromogene Phthalide
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CZ280738B6 (cs) * 1988-02-10 1996-04-17 F. Hoffmann - La Roche And Co., Aktiengesellschaft Substituované pyrroly, jejich použití pro výrobu léčiv a léčiva na jejich bázi
US5086171A (en) * 1989-03-08 1992-02-04 Appleton Papers Inc. Bis-(indolyl)ethylenes
US5116978A (en) * 1989-03-08 1992-05-26 Appleton Papers Inc. Process for bis(indolyl)ethylene synthesis
JP3038064B2 (ja) * 1991-10-07 2000-05-08 日清製粉株式会社 インドール誘導体およびこれを有効成分とする抗潰瘍薬
DE59207620D1 (de) * 1991-10-30 1997-01-16 Ciba Geigy Ag NIR-Farbstoffe, Verfahren zu ihrer Herstellung und ihre Verwendung
US5206377A (en) * 1991-12-05 1993-04-27 Whitby Research, Inc. Compounds useful as antiproliferative agents
US5407102A (en) * 1994-02-15 1995-04-18 Freudinger; Mark J. Apparatus for dispensing a quantity of flowable material
US5948808A (en) * 1997-03-07 1999-09-07 The Texas A&M University System Indole-3-carbinol, diindolylmethane and substituted analogs as antiestrogens
US5942340A (en) * 1997-10-02 1999-08-24 Xerox Corporation Indolocarbazole electroluminescent devices
US5843607A (en) * 1997-10-02 1998-12-01 Xerox Corporation Indolocarbazole photoconductors
CA2330756C (en) 1998-05-04 2007-10-02 Asta Medica Aktiengesellschaft Indole derivatives and their use for the treatment of malignant and other diseases based on pathological cell proliferation
DE69920455T2 (de) * 1998-07-08 2005-01-20 Harbor Branch Oceanographic Institution Inc., Fort Pierce Bis-indolederivate und ihre verwendung als entzündungshemmende mittel
IT1317925B1 (it) 2000-11-03 2003-07-15 Sigma Tau Ind Farmaceuti Bis-eterocicli ad attivita' antitumorale e chemosensibilizzante.
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JP2003346530A (ja) * 2002-05-23 2003-12-05 Nippon Sheet Glass Co Ltd 面状光源装置および画像読み取り装置
US6800655B2 (en) * 2002-08-20 2004-10-05 Sri International Analogs of indole-3-carbinol metabolites as chemotherapeutic and chemopreventive agents

Also Published As

Publication number Publication date
EP1530572A2 (de) 2005-05-18
US20090023796A1 (en) 2009-01-22
ATE411317T1 (de) 2008-10-15
JP2010195840A (ja) 2010-09-09
US20060128785A1 (en) 2006-06-15
CA2496203C (en) 2012-03-27
US20040043965A1 (en) 2004-03-04
US20040157906A1 (en) 2004-08-12
JP4699171B2 (ja) 2011-06-08
US6800655B2 (en) 2004-10-05
EP1530572B1 (de) 2008-10-15
JP2006036796A (ja) 2006-02-09
US7429610B2 (en) 2008-09-30
JP4764629B2 (ja) 2011-09-07
US7666897B2 (en) 2010-02-23
EP1623985A3 (de) 2011-06-08
JP2006500379A (ja) 2006-01-05
EP1623985B1 (de) 2016-02-17
CA2496203A1 (en) 2004-03-04
JP5599236B2 (ja) 2014-10-01
WO2004018475A2 (en) 2004-03-04
WO2004018475A3 (en) 2004-04-01
US7078427B2 (en) 2006-07-18
EP1623985A2 (de) 2006-02-08
AU2003263878A1 (en) 2004-03-11

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