DE60331584D1 - Modifizierte natriuretic verbindungen, konjugate und ihre verwendungen - Google Patents
Modifizierte natriuretic verbindungen, konjugate und ihre verwendungenInfo
- Publication number
- DE60331584D1 DE60331584D1 DE60331584T DE60331584T DE60331584D1 DE 60331584 D1 DE60331584 D1 DE 60331584D1 DE 60331584 T DE60331584 T DE 60331584T DE 60331584 T DE60331584 T DE 60331584T DE 60331584 D1 DE60331584 D1 DE 60331584D1
- Authority
- DE
- Germany
- Prior art keywords
- conjugates
- compounds
- disclosed
- natriuretic
- modified
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G65/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
- C08G65/02—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring
- C08G65/32—Polymers modified by chemical after-treatment
- C08G65/329—Polymers modified by chemical after-treatment with organic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
- A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/58—Atrial natriuretic factor complex; Atriopeptin; Atrial natriuretic peptide [ANP]; Cardionatrin; Cardiodilatin
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/72—Receptors; Cell surface antigens; Cell surface determinants for hormones
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- C08L2203/00—Applications
- C08L2203/02—Applications for biomedical use
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Cardiology (AREA)
- Biophysics (AREA)
- Zoology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Endocrinology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biochemistry (AREA)
- Toxicology (AREA)
- Gastroenterology & Hepatology (AREA)
- Heart & Thoracic Surgery (AREA)
- Immunology (AREA)
- Cell Biology (AREA)
- Epidemiology (AREA)
- Polymers & Plastics (AREA)
- Hospice & Palliative Care (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Separation Using Semi-Permeable Membranes (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US42915102P | 2002-11-26 | 2002-11-26 | |
PCT/US2003/037996 WO2004047871A2 (en) | 2002-11-26 | 2003-11-12 | Modified naturetic compounds, conjugates, and uses thereof |
Publications (1)
Publication Number | Publication Date |
---|---|
DE60331584D1 true DE60331584D1 (de) | 2010-04-15 |
Family
ID=32393512
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE60331584T Expired - Lifetime DE60331584D1 (de) | 2002-11-26 | 2003-11-12 | Modifizierte natriuretic verbindungen, konjugate und ihre verwendungen |
Country Status (13)
Country | Link |
---|---|
US (1) | US7662773B2 (de) |
EP (1) | EP1569683B1 (de) |
JP (1) | JP2006515579A (de) |
CN (1) | CN100558398C (de) |
AT (1) | ATE459370T1 (de) |
AU (2) | AU2003297583B2 (de) |
BR (1) | BR0316560A (de) |
CA (1) | CA2504287A1 (de) |
DE (1) | DE60331584D1 (de) |
HK (1) | HK1087327A1 (de) |
PL (1) | PL377813A1 (de) |
SG (1) | SG159387A1 (de) |
WO (1) | WO2004047871A2 (de) |
Families Citing this family (80)
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US7524635B2 (en) * | 2003-04-17 | 2009-04-28 | Biosite Incorporated | Methods and compositions for measuring natriuretic peptides and uses thereof |
AU2003268531A1 (en) * | 2002-09-06 | 2004-03-29 | University Of South Florida | Materials and methods for treatment of allergic diseases |
US20080214437A1 (en) * | 2002-09-06 | 2008-09-04 | Mohapatra Shyam S | Methods and compositions for reducing activity of the atrial natriuretic peptide receptor and for treatment of diseases |
US20060110359A1 (en) * | 2002-09-06 | 2006-05-25 | Juan Sanchez-Ramos | Cellular delivery of natriuretic peptides |
DE60331584D1 (de) | 2002-11-26 | 2010-04-15 | Biocon Ltd | Modifizierte natriuretic verbindungen, konjugate und ihre verwendungen |
US7648962B2 (en) * | 2002-11-26 | 2010-01-19 | Biocon Limited | Natriuretic compounds, conjugates, and uses thereof |
JP4880461B2 (ja) | 2003-08-13 | 2012-02-22 | バイオコン・リミテッド | 治療薬用のマイクロ粒子脂肪酸塩固体製剤 |
EP1727556A2 (de) * | 2004-02-17 | 2006-12-06 | University Of South Florida | Material und methoden zur behandlung von entzündlichen erkrankungen und zellproliferationsstörungen |
EP3404102B1 (de) | 2004-04-21 | 2021-08-11 | Alexion Pharmaceuticals, Inc. | Knochenfreisetzungskonjugate und verfahren zur verwendung davon zum zielen von proteinen auf knochen |
WO2006005140A2 (en) | 2004-07-15 | 2006-01-19 | The University Of Queensland | Proteinaceous compounds and uses therefor |
US20080207505A1 (en) * | 2005-01-12 | 2008-08-28 | James Kenneth D | Bna Conjugates and Methods of Use |
US7300494B2 (en) * | 2005-02-24 | 2007-11-27 | Hamilton Sundstrand Corporation | On-board inert gas generation system with compressor surge protection |
HUE026231T2 (en) | 2005-04-07 | 2016-06-28 | Cardiorentis Ag | Use of a natriuretic peptide for the treatment of heart failure |
RS53847B1 (en) | 2005-07-29 | 2015-08-31 | Nektar Therapeutics | PROCEDURES FOR OBTAINING POLYMER REAGENTS |
US7803901B2 (en) | 2005-09-16 | 2010-09-28 | Mayo Foundation For Medical Education And Research | Polypeptides with natriuresis activity |
US8759290B2 (en) * | 2005-10-18 | 2014-06-24 | Biocon Limited | Oral glucagon-like peptide conjugates for metabolic diseases |
AU2007233123A1 (en) | 2006-03-30 | 2007-10-11 | Palatin Technologies, Inc. | Linear natriuretic peptide constructs |
WO2007115175A2 (en) | 2006-03-30 | 2007-10-11 | Palatin Technologies, Inc. | Cyclic natriuretic peptide constructs |
EP2051585A4 (de) * | 2006-04-28 | 2010-06-02 | Univ South Florida | Materialien und verfahren zur unterdrückung von entzündungen durch hemmung des vorhof-rezeptors für natriuretische peptide |
DK2687223T3 (en) | 2006-05-30 | 2017-10-23 | Mayo Foundation | Detection and treatment of dementia |
EP2687223B1 (de) | 2006-05-30 | 2017-07-12 | Mayo Foundation For Medical Education And Research | Erkennung und Behandlung von Demenz |
WO2007143561A1 (en) | 2006-06-01 | 2007-12-13 | Mayo Foundation For Medical Education And Research | Immunity to folate receptors |
WO2008088582A2 (en) | 2006-08-04 | 2008-07-24 | Mayo Foundation For Medical Education And Research | Methods and materials related to trail isoforms |
CA2662453A1 (en) * | 2006-09-08 | 2008-03-13 | Mayo Foundation For Medical Education And Research | Aquaretic and natriuretic polypeptides lacking vasodilatory activity |
US8728532B2 (en) | 2007-04-12 | 2014-05-20 | Regents Of The University Of Minnesota | Ischemia/reperfusion protection compositions and methods of using |
KR20080098216A (ko) * | 2007-05-04 | 2008-11-07 | 한미약품 주식회사 | 캐리어 물질을 이용한 나트륨 배설 펩타이드 약물 결합체 |
JP2011504506A (ja) | 2007-11-21 | 2011-02-10 | バイオマリン ファーマシューティカル インコーポレイテッド | C型ナトリウム利尿ペプチドの変異体 |
WO2009156481A1 (en) * | 2008-06-25 | 2009-12-30 | Ascendis Pharma As | Pegylated bnp |
EP2898900B1 (de) | 2008-09-19 | 2017-11-15 | Nektar Therapeutics | Polymerkonjugate von Ziconotid |
US8449872B2 (en) | 2008-09-19 | 2013-05-28 | Nektar Therapeutics | Polymer conjugates of nesiritide peptides |
CA2758581C (en) | 2009-05-20 | 2022-06-14 | Biomarin Pharmaceutical Inc. | Variants of c-type natriuretic peptide |
WO2011005939A2 (en) | 2009-07-09 | 2011-01-13 | Mayo Foundation For Medical Education And Research | Long acting atrial natriuretic peptide (la-anp) and methods for use thereof |
CA2768810C (en) | 2009-07-23 | 2014-05-20 | Igisu Co., Ltd. | Skin external-preparation composition |
WO2011136744A1 (en) | 2010-04-27 | 2011-11-03 | Agency For Science, Technology And Research | Eif4e binding peptides |
WO2012013597A1 (de) * | 2010-07-28 | 2012-02-02 | Justus-Liebig-Universität Giessen | Stoffe und deren verwendung zur beeinflussung natriuretischer peptidrezeptoren |
CA2823066A1 (en) | 2010-12-27 | 2012-07-05 | Alexion Pharma International Sarl | Compositions comprising natriuretic peptides and methods of use thereof |
EP2678002A2 (de) | 2011-02-25 | 2014-01-01 | Medtronic, Inc. | Therapie für nierenerkrankungen und/oder herzinsuffizienz |
US20140072557A1 (en) | 2011-02-28 | 2014-03-13 | National Cerebral And Cardiovascular Center | Medicinal agent for suppressing malignant tumor metastasis |
US10184942B2 (en) | 2011-03-17 | 2019-01-22 | University Of South Florida | Natriuretic peptide receptor as a biomarker for diagnosis and prognosis of cancer |
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EP3400019B1 (de) * | 2016-01-08 | 2022-09-28 | Ascendis Pharma Growth Disorders A/S | Cnp-prodroge mit trägerbefestigung am zylischen teil des peptids |
CA3008017C (en) * | 2016-01-08 | 2024-01-02 | Ascendis Pharma Growth Disorders A/S | Controlled-release cnp agonists with reduced side-effects |
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-
2003
- 2003-11-12 DE DE60331584T patent/DE60331584D1/de not_active Expired - Lifetime
- 2003-11-12 BR BR0316560-4A patent/BR0316560A/pt not_active IP Right Cessation
- 2003-11-12 EP EP03812053A patent/EP1569683B1/de not_active Expired - Lifetime
- 2003-11-12 CN CNB2003801091794A patent/CN100558398C/zh not_active Expired - Fee Related
- 2003-11-12 AU AU2003297583A patent/AU2003297583B2/en not_active Ceased
- 2003-11-12 AT AT03812053T patent/ATE459370T1/de not_active IP Right Cessation
- 2003-11-12 WO PCT/US2003/037996 patent/WO2004047871A2/en active Application Filing
- 2003-11-12 PL PL377813A patent/PL377813A1/pl not_active Application Discontinuation
- 2003-11-12 CA CA002504287A patent/CA2504287A1/en not_active Abandoned
- 2003-11-12 SG SG200703827-6A patent/SG159387A1/en unknown
- 2003-11-26 US US10/723,933 patent/US7662773B2/en not_active Expired - Fee Related
- 2003-11-26 JP JP2004555809A patent/JP2006515579A/ja active Pending
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2006
- 2006-07-04 HK HK06107556.5A patent/HK1087327A1/xx not_active IP Right Cessation
-
2010
- 2010-04-13 AU AU2010201455A patent/AU2010201455A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
CN100558398C (zh) | 2009-11-11 |
US20040203081A1 (en) | 2004-10-14 |
EP1569683B1 (de) | 2010-03-03 |
JP2006515579A (ja) | 2006-06-01 |
CN1741814A (zh) | 2006-03-01 |
WO2004047871A2 (en) | 2004-06-10 |
ATE459370T1 (de) | 2010-03-15 |
AU2003297583B2 (en) | 2010-01-14 |
CA2504287A1 (en) | 2004-06-10 |
AU2003297583A1 (en) | 2004-06-18 |
US7662773B2 (en) | 2010-02-16 |
PL377813A1 (pl) | 2006-02-20 |
WO2004047871A3 (en) | 2005-03-17 |
AU2010201455A1 (en) | 2010-05-06 |
EP1569683A2 (de) | 2005-09-07 |
BR0316560A (pt) | 2005-10-04 |
HK1087327A1 (en) | 2006-10-13 |
SG159387A1 (en) | 2010-03-30 |
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