DE60332663D1 - CCR1-Rezeptor-Antagonisten zur Behandlung u.a. Demyelinisierender entzündlicher Erkrankungen - Google Patents

CCR1-Rezeptor-Antagonisten zur Behandlung u.a. Demyelinisierender entzündlicher Erkrankungen

Info

Publication number
DE60332663D1
DE60332663D1 DE60332663T DE60332663T DE60332663D1 DE 60332663 D1 DE60332663 D1 DE 60332663D1 DE 60332663 T DE60332663 T DE 60332663T DE 60332663 T DE60332663 T DE 60332663T DE 60332663 D1 DE60332663 D1 DE 60332663D1
Authority
DE
Germany
Prior art keywords
treatment
receptor antagonists
inflammatory diseases
ccr1 receptor
demyelinating inflammatory
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60332663T
Other languages
English (en)
Inventor
Kenneth G Carson
Geraldine C Harriman
Us Massachusetts
Shomir Ghosh
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Millennium Pharmaceuticals Inc
Original Assignee
Millennium Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Millennium Pharmaceuticals Inc filed Critical Millennium Pharmaceuticals Inc
Application granted granted Critical
Publication of DE60332663D1 publication Critical patent/DE60332663D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
DE60332663T 2002-11-13 2003-11-12 CCR1-Rezeptor-Antagonisten zur Behandlung u.a. Demyelinisierender entzündlicher Erkrankungen Expired - Lifetime DE60332663D1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US42594702P 2002-11-13 2002-11-13

Publications (1)

Publication Number Publication Date
DE60332663D1 true DE60332663D1 (de) 2010-07-01

Family

ID=32313083

Family Applications (2)

Application Number Title Priority Date Filing Date
DE2003605063 Expired - Lifetime DE60305063T2 (de) 2002-11-13 2003-11-12 Ccr1-rezeptor-antagonisten zur behandlung von u.a. demyelinisierenden entzündlichen erkrankungen
DE60332663T Expired - Lifetime DE60332663D1 (de) 2002-11-13 2003-11-12 CCR1-Rezeptor-Antagonisten zur Behandlung u.a. Demyelinisierender entzündlicher Erkrankungen

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DE2003605063 Expired - Lifetime DE60305063T2 (de) 2002-11-13 2003-11-12 Ccr1-rezeptor-antagonisten zur behandlung von u.a. demyelinisierenden entzündlichen erkrankungen

Country Status (25)

Country Link
US (7) US20040106639A1 (de)
EP (2) EP1669356B1 (de)
JP (1) JP4644491B2 (de)
KR (1) KR101109348B1 (de)
CN (1) CN100343257C (de)
AR (1) AR041942A1 (de)
AT (2) ATE468340T1 (de)
AU (2) AU2003291452A1 (de)
BR (1) BR0316261A (de)
CA (1) CA2505874C (de)
CY (1) CY1107985T1 (de)
DE (2) DE60305063T2 (de)
DK (1) DK1562954T3 (de)
EA (1) EA007748B1 (de)
ES (2) ES2346337T3 (de)
HK (2) HK1086011A1 (de)
IL (2) IL168384A (de)
MX (1) MXPA05005105A (de)
NO (1) NO331855B1 (de)
PL (1) PL211022B1 (de)
PT (1) PT1562954E (de)
SI (1) SI1562954T1 (de)
TW (1) TWI291467B (de)
WO (1) WO2004043965A1 (de)
ZA (2) ZA200504144B (de)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7271176B2 (en) * 1998-09-04 2007-09-18 Millennium Pharmaceuticals, Inc. Chemokine receptor antagonists and methods of use thereof
US7541365B2 (en) 2001-11-21 2009-06-02 Millennium Pharmaceuticals, Inc. Chemokine receptor antagonists and methods of use therefor
TWI291467B (en) * 2002-11-13 2007-12-21 Millennium Pharm Inc CCR1 antagonists and methods of use therefor
US7838522B2 (en) 2004-11-17 2010-11-23 Ares Trading S.A. Benzothiazole formulations and use thereof
EP1841429B1 (de) * 2004-12-17 2012-04-18 Millennium Pharmaceuticals, Inc. Solide formen eines chemokin-rezeptorantagonisten und anwendungsverfahren dafür
AU2005318163B2 (en) 2004-12-21 2011-12-01 Merck Serono Sa Sulfonyl amino cyclic derivatives and use thereof
UA86862C2 (en) 2005-01-31 2009-05-25 Лаборатуар Сероно С.А. N-hydroxyamide derivatives and use thereof
BRPI0613042A2 (pt) 2005-07-15 2010-12-14 Serono Lab inibidores de jnk para o tratamento de endometriose
KR20080044836A (ko) 2005-07-15 2008-05-21 라보라뚜와르 세로노 에스. 에이. 자궁내막증 치료용 ｊｎｋ 억제제
WO2007025991A2 (en) 2005-09-01 2007-03-08 Ares Trading S.A. Treatment of optic neuritis
US7601844B2 (en) 2006-01-27 2009-10-13 Bristol-Myers Squibb Company Piperidinyl derivatives as modulators of chemokine receptor activity
JP5189091B2 (ja) 2006-07-14 2013-04-24 イーライ リリー アンド カンパニー グルココルチコイド受容体モジュレーターおよびその使用方法
WO2009015164A2 (en) * 2007-07-24 2009-01-29 Bristol-Myers Squibb Company Piperidinyl derivatives as modulators of chemokine receptor activity
WO2009082526A2 (en) * 2007-10-05 2009-07-02 Pharmacopeia, Inc. Ortho pyrrolidine, benzyl-substituted heterocycle ccr1 antagonists for autoimmune diseases & inflammation
WO2009073462A1 (en) * 2007-11-30 2009-06-11 Millennium Pharmaceuticals, Inc. Process for the preparation of 5-cyclopropyl-5, 11-dihydro (1) benzoxepino (3, 4-b) -pyridin-5-ol using tmeda
US20090286823A1 (en) * 2007-12-17 2009-11-19 Millennium Pharmaceuticals Inc. CCR1 Inhibitors useful for the treatment of multiple myeloma and other disorders
EA017288B1 (ru) 2008-01-11 2012-11-30 Эли Лилли Энд Компани (E)-N-{3-[1-(8-ФТОР-11Н-10-ОКСА-1-АЗАДИБЕНЗО[a,d]ЦИКЛОГЕПТЕН-5-ИЛИДЕН)ПРОПИЛ]ФЕНИЛ}МЕТАНСУЛЬФОНАМИД В КАЧЕСТВЕ МОДУЛЯТОРА РЕЦЕПТОРОВ ГЛЮКОКОРТИКОИДОВ ДЛЯ ЛЕЧЕНИЯ РЕВМАТИЗМА
TWI433838B (zh) 2008-06-25 2014-04-11 必治妥美雅史谷比公司 作為趨化因子受體活性調節劑之六氫吡啶衍生物
EP2771484A1 (de) 2011-10-28 2014-09-03 Galderma Research & Development Neue leukozyteninfiltratmarker für rosacea und verwendungen davon

Family Cites Families (104)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US377729A (en) * 1888-02-07 Half to phillips
DE80449C (de)
DD80449A (de)
GB1003292A (en) 1960-12-08 1965-09-02 Sandoz Ag Improvements in or relating to 4-azathiaxanthene derivatives
FR1332145A (de) 1961-06-08 1963-12-16
CH416624A (de) 1962-10-23 1966-07-15 Sandoz Ag Verfahren zur Herstellung von neuen heterocyclischen Verbindungen
NL132137C (de) * 1963-04-24
FR88751E (de) 1963-07-09 1967-06-07
GB1085405A (en) 1963-10-14 1967-10-04 Pfizer & Co C Dibenzoxepins and dibenzthiepins
BE664609A (de) 1964-06-01
CH421138A (de) 1965-11-04 1966-09-30 Wander Ag Dr A Verfahren zur Herstellung von Thioxanthenderivaten
US3409621A (en) * 1966-04-01 1968-11-05 Schering Corp Piperazino-aza-dibenzo-[a, d]-cycloheptenes
US3625974A (en) 1967-04-28 1971-12-07 Fujisawa Pharmaceutical Co Dibenzothiazepine derivatives
GB1206216A (en) 1967-07-18 1970-09-23 Pfizer & Co C Aminopropylidene dibenzoxepine tranquilizers
NL6905642A (de) 1968-04-12 1969-10-14
JPS4830064B1 (de) 1968-12-23 1973-09-17
JPS4840356Y1 (de) 1969-12-22 1973-11-27
US3770729A (en) * 1970-12-22 1973-11-06 Yoshitomi Pharmaceutical N substituted piperidine compounds
GB1330966A (en) 1970-12-22 1973-09-19 Yoshitomi Pharmaceutical N-substituted piperidine compounds methods for their production and pharmaceutical compositions containing them
JPS5146625Y2 (de) 1971-03-24 1976-11-10
GB1323659A (en) 1971-04-10 1973-07-18 Yoshitomi Pharmaceutical Piperazine derivatives methods for their production and pharmaceuticl compositions containing them
CA1010870A (en) * 1972-12-08 1977-05-24 Niels Lassen Thiaxanthene derivative and method
US4250176A (en) * 1976-12-21 1981-02-10 Janssen Pharmaceutica N.V. Piperazine derivatives
US4335122A (en) * 1981-03-18 1982-06-15 Hoechst-Roussel Pharmaceuticals Inc. Dihydro-dibenzoxepines-thiepines and -morphanthridones, compositions and use
DE3326641A1 (de) 1982-07-27 1984-02-02 Basf Ag, 6700 Ludwigshafen 5,6-dihydro-11-h-morphantridin-6-one, ihre herstellung und diese enthaltende arzneimittel
CA1237428A (en) * 1983-06-24 1988-05-31 Hiroshi Tanaka ¬1| benzepino¬3,4-b|pyridine derivative
ES8502099A1 (es) 1983-08-02 1984-12-16 Espanola Farma Therapeut Procedimiento de obtencion de nuevos compuestos derivados de la difenil-metilen-etilamina.
DE3402060A1 (de) * 1984-01-21 1985-08-01 Dr. Karl Thomae Gmbh, 7950 Biberach Substituierte 5,11-dihydro-6h-dibenz(b,e)azepin-6-one, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
CS236550B1 (cs) 1984-02-02 1985-05-15 Miroslav Protiva Způsob přípravy esterů piperazinoalkanolů dibenzo(b,e)thiepinové řady a jejich solí s kyselinou maleinovou
CS236549B1 (cs) 1984-02-02 1985-05-15 Miroslav Protiva Piperazinoalkanoly dibenzo(b,e)thiepinové řady a jejich soli s kyselinou maleinovou
CS240698B1 (cs) 1984-10-12 1986-02-13 Miroslav Protiva Substituované ll-(piperidinoalkyl)-6,ll-dihydrodibenzo (b,e)thiepin-ll-karbonitrily
JPH0665664B2 (ja) 1985-01-18 1994-08-24 大塚製薬株式会社 モルフアントリジン誘導体
SE8500273D0 (sv) * 1985-01-22 1985-01-22 Leo Ab Nya tricykliska foreningar, kompositioner innehallande sadana foreningar, framstellningsforfaranden och behandlingsmetoder
JPS6310784A (ja) * 1986-03-03 1988-01-18 Kyowa Hakko Kogyo Co Ltd 抗アレルギー剤
WO1988000049A1 (en) 1986-06-26 1988-01-14 Kyowa Hakko Kogyo Co., Ltd. Antiarrhythmic agent
US5089496A (en) * 1986-10-31 1992-02-18 Schering Corporation Benzo[5,6]cycloheptapyridine compounds, compositions and method of treating allergies
IT8721978A0 (it) 1987-09-21 1987-09-21 Angeli Inst Spa Nuovi derivati ammidinici triciclici.
US4882351A (en) * 1987-10-14 1989-11-21 Roussel Uclaf Tricyclic compounds
US4994463A (en) * 1987-12-14 1991-02-19 Kyowa Hakko Kogyo Co., Ltd. Tricyclic thromboxane A2 antagonists
NZ228888A (en) 1988-04-28 1991-12-23 Schering Corp Derivatives of piperidine, piperidylidene and piperazine and pharmaceutical compositions
US4999363A (en) * 1988-06-09 1991-03-12 Kyowa Hakko Kogyo Co., Ltd. Tricyclic compounds
US5242931A (en) * 1988-06-09 1993-09-07 Kyowa Hakko Kogyo Co., Ltd. Tricyclic compounds as TXA2 antagonists
DE3827093A1 (de) 1988-08-10 1990-02-15 Nattermann A & Cie Verfahren zur herstellung von hochreinem ebselen
DE3838912A1 (de) * 1988-11-17 1990-05-23 Thomae Gmbh Dr K Mittel zur behandlung von akuten und chronischen obstruktiven atemwegserkrankungen
JPH0694464B2 (ja) * 1991-01-23 1994-11-24 協和醗酵工業株式会社 三環式化合物およびその中間体
CA2062587A1 (en) * 1991-03-11 1992-09-12 Toshiaki Kumazawa Indole derivatives
WO1992016226A1 (en) 1991-03-19 1992-10-01 Smithkline Beecham Corporation Il-1 inhibitors
AU2028892A (en) 1991-05-23 1992-12-30 Schering Corporation Novel benzopyrido piperidylidene compounds, compositions, methods of manufacture and methods of use
EP0524784A1 (de) 1991-07-23 1993-01-27 Schering Corporation Benzopyridopiperidyliden-Verbindungen, als PAF-Antagonisten
US5378701A (en) * 1991-12-27 1995-01-03 Kyowa Hakko Kogyo Tricyclic compounds
US5679703A (en) * 1992-09-16 1997-10-21 Kyowa Hakko Kogyo, Co., Ltd. Tricyclic compounds having ACAT inhibiting activity
JP3664176B2 (ja) 1992-11-10 2005-06-22 ジェネンテック・インコーポレーテッド Ｃ−ｃ ｃｋｒ−１，ｃ−ｃケモカインレセプター
US5538986A (en) * 1993-12-06 1996-07-23 Schering Corporation Tricyclic derivatives, compositions and methods of use
MY113463A (en) * 1994-01-04 2002-03-30 Novo Nordisk As Novel heterocyclic compounds
US5712280A (en) * 1995-04-07 1998-01-27 Schering Corporation Tricyclic compounds useful for inhibition of G-protein function and for treatment of proliferative diseases
AU5271096A (en) 1995-04-07 1996-10-23 Novo Nordisk A/S Novel heterocyclic compounds
US5801175A (en) * 1995-04-07 1998-09-01 Schering Corporation Tricyclic compounds useful for inhibition of G-protein function and for treatment of proliferative diseases
UA54385C2 (uk) 1995-04-07 2003-03-17 Ново Нордіск А/С N-заміщені азагетероциклічні карбонові кислоти та їх ефіри, спосіб їх одержання, фармацевтична композиція та спосіб лікування
AU5270796A (en) 1995-04-07 1996-10-23 Novo Nordisk A/S N-substituted azaheterocyclic carboxylic acids and esters th ereof
JPH0940662A (ja) 1995-05-24 1997-02-10 Kyowa Hakko Kogyo Co Ltd 三環式化合物
CA2231773A1 (en) * 1995-09-13 1997-03-20 Shigeru Aono Phenylpiperidine derivative
AU1208397A (en) 1995-12-28 1997-07-28 Takeda Chemical Industries Ltd. Diphenylmethane derivatives as mip-1alpha/rantes receptor antagonists
DE29602088U1 (de) 1996-02-07 1996-04-04 Buemach Engineering Internatio Verschraubbarer druckmittelbetätigter Arbeitszylinder mit Verschlußteilen zur Kopplung des Zylinderrohres
US6686353B1 (en) 1996-05-20 2004-02-03 Teijin Intellectual Property Center Limited Diarylalkyl cyclic diamine derivatives as chemokine receptor antagonists
US6323206B1 (en) 1996-07-12 2001-11-27 Millennium Pharmaceuticals, Inc. Chemokine receptor antagonists and methods of use therefor
AU729415B2 (en) 1996-07-12 2001-02-01 Millennium Pharmaceuticals, Inc. Chemokine receptor antagonists and methods of use therefor
US6140338A (en) 1996-07-29 2000-10-31 Banyu Pharmaceutical, Co., Ltd. Chemokine receptor antagonists
CN1237169A (zh) 1996-09-13 1999-12-01 先灵公司 用于抑制g－蛋白功能并用于治疗增生性疾病的三环化合物
KR20000036120A (ko) 1996-09-13 2000-06-26 둘락 노먼 씨. 파르네실 단백질 트랜스퍼라제에 대한 트리사이클릭 저해제
IL128931A0 (en) 1996-09-13 2000-02-17 Schering Corp Tricylic antitumor compounds being farnesyl protein transferase inhibitors
JP2001500505A (ja) 1996-09-13 2001-01-16 シェーリング コーポレイション Ｆｐｔインヒビターとして有用な三環式化合物
CN1104428C (zh) 1996-09-13 2003-04-02 先灵公司 用作法呢基－蛋白转移酶抑制剂的取代的苯并芳庚并吡啶
PL332253A1 (en) 1996-09-13 1999-08-30 Schering Corp Derivatives of subtituted benzocycloheptapyridine useful in inhibiting proteinous farnesil transferase
CN1237170A (zh) 1996-09-13 1999-12-01 先灵公司 用作法呢基蛋白转移酶抑制剂的新的三环哌啶基化合物
ZA978792B (en) 1996-10-04 1998-04-06 Novo Nordisk As N-substituted azaheterocyclic compounds.
CA2267500A1 (en) 1996-10-04 1998-04-16 Novo Nordisk A/S N-substituted azaheterocyclic compounds
AU740662B2 (en) 1996-10-04 2001-11-08 Novo Nordisk A/S 1,4-disubstituted piperazines
WO1998025617A1 (en) 1996-12-13 1998-06-18 Merck & Co., Inc. Substituted aryl piperazines as modulators of chemokine receptor activity
AU5803398A (en) 1996-12-13 1998-07-03 Merck & Co., Inc. Spiro-substituted azacycles as modulators of chemokine receptor activity
WO1998025604A1 (en) 1996-12-13 1998-06-18 Merck & Co., Inc. Spiro-substituted azacycles as modulators of chemokine receptor activity
AU5812498A (en) 1996-12-20 1998-07-17 Merck & Co., Inc. Substituted aminoquinolines as modulators of chemokine receptor activity
US5919776A (en) * 1996-12-20 1999-07-06 Merck & Co., Inc. Substituted aminoquinolines as modulators of chemokine receptor activity
AU6517398A (en) 1997-03-27 1998-10-22 Kyowa Hakko Kogyo Co. Ltd. Therapeutic agent for autoimmune diseases
US5877177A (en) * 1997-06-17 1999-03-02 Schering Corporation Carboxy piperidylacetamide tricyclic compounds useful for inhibition of G-protein function and for treatment of proliferative diseases
JP2002515914A (ja) 1997-06-25 2002-05-28 ノボ ノルディスク アクティーゼルスカブ 新規へテロ環式化合物
US6040318A (en) 1997-06-25 2000-03-21 Novo Nordisk A/S Tricycle substituted with azaheterocyclic carboxylic acids
US6048856A (en) * 1997-12-17 2000-04-11 Novo Nordisk A/S Heterocyclic compounds
ATE309249T1 (de) * 1998-01-21 2005-11-15 Millennium Pharm Inc Chemokin rezeptor antagonisten und verwndung
US6613905B1 (en) * 1998-01-21 2003-09-02 Millennium Pharmaceuticals, Inc. Chemokine receptor antagonists and methods of use therefor
CA2318088A1 (en) 1998-01-21 1999-07-29 Yoshisuke Nakasato Chemokine receptor antagonists and methods of use therefor
US6509346B2 (en) * 1998-01-21 2003-01-21 Millennium Pharmaceuticals, Inc. Chemokine receptor antagonists and methods of use therefor
US6503926B2 (en) * 1998-09-04 2003-01-07 Millennium Pharmaceuticals, Inc. Chemokine receptor antagonists and methods of use therefor
WO2003045942A2 (en) 1998-09-04 2003-06-05 Millennium Pharmaceuticals, Inc. Chemokine receptor antagonists and methods of use thereof
US7271176B2 (en) * 1998-09-04 2007-09-18 Millennium Pharmaceuticals, Inc. Chemokine receptor antagonists and methods of use thereof
EP1109815A1 (de) 1998-09-04 2001-06-27 Millennium Pharmaceuticals, Inc. Chemokin-rezeptor-antagonisten und verwendung
US20020169155A1 (en) * 1998-09-04 2002-11-14 Millennium Pharmaceuticals, Inc. Chemokine receptor anagonists and methods of use therefor
US6288083B1 (en) 1998-09-04 2001-09-11 Millennium Pharmaceuticals, Inc. Chemokine receptor antagonists and methods of use therefor
EP1135129A1 (de) 1998-12-02 2001-09-26 Novo Nordisk A/S Verwendung von n-substituierten azaheterocyclischer verbindungen zur herstellung einer pharmazeutischen zusammensetzung zur behandlung von angiogenese-relatierter zustanden
EP1204640A2 (de) 1999-07-28 2002-05-15 Millennium Pharmaceuticals, Inc. Chemokinrezeptor-antagonisten und verfahren zu ihrer anwendung
EP1204664A1 (de) * 1999-07-28 2002-05-15 Millennium Pharmaceuticals, Inc. Chemokin-rezeptor-antagonisten und methoden ihrer anwendung
PL403800A1 (pl) * 2001-11-21 2013-08-19 Millennium Pharmaceuticals, Inc. Kompozycja farmaceutyczna
TWI291467B (en) * 2002-11-13 2007-12-21 Millennium Pharm Inc CCR1 antagonists and methods of use therefor
WO2006114870A1 (ja) 2005-04-20 2006-11-02 Mitsubishi Denki Kabushiki Kaisha 過電流継電器
JP4715952B2 (ja) 2009-02-18 2011-07-06 村田機械株式会社 フロッグレッグ型移載装置

Also Published As

Publication number Publication date
US7732459B2 (en) 2010-06-08
EP1669356B1 (de) 2010-05-19
CA2505874A1 (en) 2004-05-27
CA2505874C (en) 2012-07-17
WO2004043965A1 (en) 2004-05-27
EP1562954B1 (de) 2006-05-03
PL211022B1 (pl) 2012-03-30
US20110230516A1 (en) 2011-09-22
TWI291467B (en) 2007-12-21
EA007748B1 (ru) 2006-12-29
ATE325124T1 (de) 2006-06-15
US20150005338A1 (en) 2015-01-01
US20040106639A1 (en) 2004-06-03
NO331855B1 (no) 2012-04-23
CN100343257C (zh) 2007-10-17
US9334283B2 (en) 2016-05-10
US8394817B2 (en) 2013-03-12
MXPA05005105A (es) 2005-07-01
ES2261979T3 (es) 2006-11-16
AU2003291452A1 (en) 2004-06-03
EP1562954A1 (de) 2005-08-17
AR041942A1 (es) 2005-06-01
EA200500803A1 (ru) 2005-10-27
US20050288319A1 (en) 2005-12-29
US20130289063A1 (en) 2013-10-31
IL168384A (en) 2011-01-31
ES2346337T3 (es) 2010-10-14
SI1562954T1 (sl) 2006-10-31
US7977350B2 (en) 2011-07-12
JP2006508966A (ja) 2006-03-16
PT1562954E (pt) 2006-07-31
NO20052272L (no) 2005-06-06
HK1086011A1 (en) 2006-09-08
EP1669356A1 (de) 2006-06-14
JP4644491B2 (ja) 2011-03-02
DE60305063D1 (de) 2006-06-08
DK1562954T3 (da) 2006-08-28
IL210046A0 (en) 2011-07-31
US20100249174A1 (en) 2010-09-30
AU2008202965A1 (en) 2008-07-31
DE60305063T2 (de) 2006-11-16
KR20050074609A (ko) 2005-07-18
AU2008202965B2 (en) 2012-03-22
CY1107985T1 (el) 2013-09-04
ZA200607868B (en) 2008-01-08
CN1738824A (zh) 2006-02-22
BR0316261A (pt) 2005-10-11
ATE468340T1 (de) 2010-06-15
ZA200504144B (en) 2007-04-25
PL377715A1 (pl) 2006-02-06
HK1074046A1 (en) 2005-10-28
KR101109348B1 (ko) 2012-01-31
IL210046A (en) 2015-07-30
US20080139602A1 (en) 2008-06-12
TW200413347A (en) 2004-08-01

Similar Documents

Publication Publication Date Title
IL210046A0 (en) Ccr1 antagonists for the treatment of i.a. demyelinating inflammatory disease
NO20052589D0 (no) Fremgangsmate for fremstilling av vektredusert gips.
PL380828A1 (pl) Fosfoniany, amidomonofosfoniany, amidobisfosfoniany do leczenia chorób wirusowych
IS2722B (is) 1, 2, 3, 4- Tetrasetin indól til meðhöndlunar á öndunarfærasjúkdómum
AT507045A5 (de) Implantierbare, gewebe-stimulierende vorrichtung
PT1522314E (pt) Medicamentos para doenças causadas pela contracção ou dilatação vascular
NO20053126D0 (no) Kontrollsystem for medisinsk behandling.
BR0315742B1 (pt) conjunto de filtro.
ES1048994Y (es) Nido desechable para cunicultura.
NO20044188L (no) Kontrollerte frigjoringsdoseformer
AU2003303217A8 (en) Use of substituted 2,5-diamidoindoles for the treatment of urological diseases
ATE378053T1 (de) Pharmazeutische zusammensetzungen zur behandlung von nierenfunktionsstörungen
ITTN20020014A1 (it) Apparecchio ortodontico.
ITRM20020314A0 (it) Impianto penieno apicale per falloplastica di ingrandimento.
ES1049838Y (es) Calzado perfeccionado.
ES1053198Y (es) Implante dental.
RU2005128615A (ru) Средство для лечения заболеваний пародонта
ITMI20031273A1 (it) Composizioni a base di cenere di vegetali per la terapia di affezioni cutanee.
ITBO20020635A1 (it) Riunito dentale.
ITCA20020017A1 (it) Distributore automatico di ossigeno terapeutico.
ITMO20020012V0 (it) Fusto artificiale per piante.
ES1048757Y (es) Calzado perfeccionado.
ES1053443Y (es) Pijama perfeccionado.
ES1053650Y (es) Implante dental mejorado.
ITRM20020328A1 (it) Matrici per dnaser.

Legal Events

Date Code Title Description
8364 No opposition during term of opposition