DE60333955D1 - Polymerbeschichtung für medizinische Geräte - Google Patents

Polymerbeschichtung für medizinische Geräte

Info

Publication number
DE60333955D1
DE60333955D1 DE60333955T DE60333955T DE60333955D1 DE 60333955 D1 DE60333955 D1 DE 60333955D1 DE 60333955 T DE60333955 T DE 60333955T DE 60333955 T DE60333955 T DE 60333955T DE 60333955 D1 DE60333955 D1 DE 60333955D1
Authority
DE
Germany
Prior art keywords
layer
polymer layer
lactone
silane derivative
functional groups
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60333955T
Other languages
English (en)
Inventor
Frantisek Rypacek
Monika Lapcikova
Ludka Machova
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Gilead Palo Alto Inc
Original Assignee
Gilead Palo Alto Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gilead Palo Alto Inc filed Critical Gilead Palo Alto Inc
Application granted granted Critical
Publication of DE60333955D1 publication Critical patent/DE60333955D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/04—Macromolecular materials
    • A61L31/06—Macromolecular materials obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/08—Materials for coatings
    • A61L31/10—Macromolecular materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L31/16—Biologically active materials, e.g. therapeutic substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L33/00—Antithrombogenic treatment of surgical articles, e.g. sutures, catheters, prostheses, or of articles for the manipulation or conditioning of blood; Materials for such treatment
    • A61L33/0076—Chemical modification of the substrate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/60—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a special physical form
    • A61L2300/606—Coatings
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00—Stock material or miscellaneous articles
    • Y10T428/13—Hollow or container type article [e.g., tube, vase, etc.]
    • Y10T428/1352—Polymer or resin containing [i.e., natural or synthetic]
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00—Stock material or miscellaneous articles
    • Y10T428/13—Hollow or container type article [e.g., tube, vase, etc.]
    • Y10T428/1352—Polymer or resin containing [i.e., natural or synthetic]
    • Y10T428/139—Open-ended, self-supporting conduit, cylinder, or tube-type article
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00—Stock material or miscellaneous articles
    • Y10T428/13—Hollow or container type article [e.g., tube, vase, etc.]
    • Y10T428/1352—Polymer or resin containing [i.e., natural or synthetic]
    • Y10T428/139—Open-ended, self-supporting conduit, cylinder, or tube-type article
    • Y10T428/1393—Multilayer [continuous layer]
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00—Stock material or miscellaneous articles
    • Y10T428/31504—Composite [nonstructural laminate]
    • Y10T428/31652—Of asbestos
    • Y10T428/31663—As siloxane, silicone or silane
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00—Stock material or miscellaneous articles
    • Y10T428/31504—Composite [nonstructural laminate]
    • Y10T428/31786—Of polyester [e.g., alkyd, etc.]
DE60333955T 2002-02-15 2003-02-14 Polymerbeschichtung für medizinische Geräte Expired - Lifetime DE60333955D1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US35757302P 2002-02-15 2002-02-15

Publications (1)

Publication Number Publication Date
DE60333955D1 true DE60333955D1 (de) 2010-10-07

Family

ID=27734757

Family Applications (2)

Application Number Title Priority Date Filing Date
DE60333955T Expired - Lifetime DE60333955D1 (de) 2002-02-15 2003-02-14 Polymerbeschichtung für medizinische Geräte
DE2003610540 Expired - Lifetime DE60310540T2 (de) 2002-02-15 2003-02-14 Polymerbeschichtung für medizinische vorrichtungen

Family Applications After (1)

Application Number Title Priority Date Filing Date
DE2003610540 Expired - Lifetime DE60310540T2 (de) 2002-02-15 2003-02-14 Polymerbeschichtung für medizinische vorrichtungen

Country Status (24)

Country Link
US (4) US7160592B2 (de)
EP (2) EP1492581B1 (de)
JP (1) JP4472348B2 (de)
KR (1) KR20040097126A (de)
CN (2) CN1279984C (de)
AT (2) ATE478696T1 (de)
AU (2) AU2003215495B2 (de)
CA (1) CA2476431A1 (de)
CY (1) CY1107549T1 (de)
DE (2) DE60333955D1 (de)
DK (2) DK1492581T3 (de)
ES (2) ES2349424T3 (de)
HK (2) HK1072205A1 (de)
HU (1) HUP0402591A2 (de)
IL (1) IL163535A0 (de)
MX (1) MXPA04007898A (de)
NO (1) NO20043843L (de)
NZ (1) NZ534682A (de)
PL (1) PL371517A1 (de)
PT (2) PT1764118E (de)
RU (1) RU2308976C2 (de)
SI (2) SI1492581T1 (de)
WO (1) WO2003068289A1 (de)
ZA (1) ZA200406448B (de)

Families Citing this family (224)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2178541C (en) * 1995-06-07 2009-11-24 Neal E. Fearnot Implantable medical device
US7713297B2 (en) 1998-04-11 2010-05-11 Boston Scientific Scimed, Inc. Drug-releasing stent with ceramic-containing layer
US7220276B1 (en) * 2000-03-06 2007-05-22 Surmodics, Inc. Endovascular graft coatings
US6512072B1 (en) 2000-06-12 2003-01-28 Dow Corning Corporation Fast cure film forming formulation
US8038708B2 (en) * 2001-02-05 2011-10-18 Cook Medical Technologies Llc Implantable device with remodelable material and covering material
US8741378B1 (en) * 2001-06-27 2014-06-03 Advanced Cardiovascular Systems, Inc. Methods of coating an implantable device
WO2003002243A2 (en) 2001-06-27 2003-01-09 Remon Medical Technologies Ltd. Method and device for electrochemical formation of therapeutic species in vivo
US20060093771A1 (en) * 2002-02-15 2006-05-04 Frantisek Rypacek Polymer coating for medical devices
WO2004028589A2 (en) * 2002-09-26 2004-04-08 Endovascular Devices, Inc. Apparatus and method for delivery of mitomycin through an eluting biocompatible implantable medical device
US7416787B2 (en) * 2003-03-31 2008-08-26 Koninklijke Philips Electronics N.V. Medical equipment provided with a coating
US20040236399A1 (en) * 2003-04-22 2004-11-25 Medtronic Vascular, Inc. Stent with improved surface adhesion
US7067169B2 (en) * 2003-06-04 2006-06-27 Chemat Technology Inc. Coated implants and methods of coating
WO2005056354A2 (en) * 2003-12-03 2005-06-23 Gedeon Anthony A Method of resisting contaminant build up and oxidation of vehicle surfaces and other surfaces
WO2005069785A2 (en) * 2003-12-16 2005-08-04 Gedeon Anthony A Method of treating surfaces for self-sterilization and microbial growth resistance
US7211108B2 (en) * 2004-01-23 2007-05-01 Icon Medical Corp. Vascular grafts with amphiphilic block copolymer coatings
US9498563B2 (en) * 2004-04-23 2016-11-22 Boston Scientific Scimed, Inc. Medical articles having therapeutic-agent-containing regions formed from coalesced polymer particles
US20060083861A1 (en) * 2004-04-24 2006-04-20 Gedeon Anthony A Method of reducing loss in power transmission systems, electrical systems and electronics
US7758892B1 (en) * 2004-05-20 2010-07-20 Boston Scientific Scimed, Inc. Medical devices having multiple layers
US20060025848A1 (en) * 2004-07-29 2006-02-02 Jan Weber Medical device having a coating layer with structural elements therein and method of making the same
US8980300B2 (en) 2004-08-05 2015-03-17 Advanced Cardiovascular Systems, Inc. Plasticizers for coating compositions
US20060029640A1 (en) * 2004-08-05 2006-02-09 Gilbert Jeremy L Medical devices with surface modification for regulating cell growth on or near the surface
EP1796690A4 (de) * 2004-09-22 2011-08-03 Cartilix Inc Knorpelfüllvorrichtung
US20060093647A1 (en) * 2004-10-29 2006-05-04 Villafana Manuel A Multiple layer coating composition
US20060095122A1 (en) * 2004-10-29 2006-05-04 Advanced Cardiovascular Systems, Inc. Implantable devices comprising biologically absorbable star polymers and methods for fabricating the same
US20060127443A1 (en) * 2004-12-09 2006-06-15 Helmus Michael N Medical devices having vapor deposited nanoporous coatings for controlled therapeutic agent delivery
US9101500B2 (en) * 2005-01-10 2015-08-11 Trireme Medical, Inc. Stent with self-deployable portion having wings of different lengths
ATE508714T1 (de) * 2005-01-10 2011-05-15 Trireme Medical Inc Stent mit selbstexpandierbarem bereich
US20060216327A1 (en) * 2005-03-28 2006-09-28 Bacterin, Inc. Multilayer coating for releasing biologically-active agents and method of making
US8778375B2 (en) * 2005-04-29 2014-07-15 Advanced Cardiovascular Systems, Inc. Amorphous poly(D,L-lactide) coating
US20070009564A1 (en) * 2005-06-22 2007-01-11 Mcclain James B Drug/polymer composite materials and methods of making the same
JP4473185B2 (ja) * 2005-07-01 2010-06-02 本田技研工業株式会社 化成処理方法、化成処理剤、及び化成処理部材
US20070038176A1 (en) * 2005-07-05 2007-02-15 Jan Weber Medical devices with machined layers for controlled communications with underlying regions
WO2007011708A2 (en) 2005-07-15 2007-01-25 Micell Technologies, Inc. Stent with polymer coating containing amorphous rapamycin
AU2006270221B2 (en) 2005-07-15 2012-01-19 Micell Technologies, Inc. Polymer coatings containing drug powder of controlled morphology
US20070020312A1 (en) * 2005-07-20 2007-01-25 Desnoyer Jessica R Method of fabricating a bioactive agent-releasing implantable medical device
WO2007016251A2 (en) * 2005-07-28 2007-02-08 Cook Incorporated Implantable thromboresistant valve
EP1984036B1 (de) * 2005-08-25 2010-06-30 Medtronic Vascular Inc. Polymere zusammensetzungen auf 4-azacaprolactonbasis, die sich für die herstellung von biologisch abbaubaren medizinischen geräten und als beschichtungen für medizinische geräte eignen
US9278161B2 (en) * 2005-09-28 2016-03-08 Atrium Medical Corporation Tissue-separating fatty acid adhesion barrier
US20090169593A1 (en) * 2005-10-19 2009-07-02 Biomedical Research Services, Inc. Method of using and producing tropoelastin and tropoelastin biomaterials
EP1962914B1 (de) 2005-11-14 2019-02-27 Biomet 3i, LLC Abscheidung von diskreten nanoteilchen auf einer implantatoberfläche
US20070196423A1 (en) * 2005-11-21 2007-08-23 Med Institute, Inc. Implantable medical device coatings with biodegradable elastomer and releasable therapeutic agent
US8840660B2 (en) 2006-01-05 2014-09-23 Boston Scientific Scimed, Inc. Bioerodible endoprostheses and methods of making the same
US20070173925A1 (en) * 2006-01-25 2007-07-26 Cornova, Inc. Flexible expandable stent
US8089029B2 (en) 2006-02-01 2012-01-03 Boston Scientific Scimed, Inc. Bioabsorbable metal medical device and method of manufacture
US20070185562A1 (en) * 2006-02-08 2007-08-09 Jgf Company Medical device for unstable and vulnerable plaque
US20070224244A1 (en) * 2006-03-22 2007-09-27 Jan Weber Corrosion resistant coatings for biodegradable metallic implants
US20070224235A1 (en) 2006-03-24 2007-09-27 Barron Tenney Medical devices having nanoporous coatings for controlled therapeutic agent delivery
US8187620B2 (en) 2006-03-27 2012-05-29 Boston Scientific Scimed, Inc. Medical devices comprising a porous metal oxide or metal material and a polymer coating for delivering therapeutic agents
US8048150B2 (en) 2006-04-12 2011-11-01 Boston Scientific Scimed, Inc. Endoprosthesis having a fiber meshwork disposed thereon
WO2007127363A2 (en) * 2006-04-26 2007-11-08 Micell Technologies, Inc. Coatings containing multiple drugs
US20070264303A1 (en) * 2006-05-12 2007-11-15 Liliana Atanasoska Coating for medical devices comprising an inorganic or ceramic oxide and a therapeutic agent
US20080097620A1 (en) * 2006-05-26 2008-04-24 Nanyang Technological University Implantable article, method of forming same and method for reducing thrombogenicity
US8815275B2 (en) 2006-06-28 2014-08-26 Boston Scientific Scimed, Inc. Coatings for medical devices comprising a therapeutic agent and a metallic material
CA2655793A1 (en) 2006-06-29 2008-01-03 Boston Scientific Limited Medical devices with selective coating
EP3009477B1 (de) 2006-07-20 2024-01-24 Orbusneich Medical Pte. Ltd Bioresorbierbare polymerzusammensetzung für eine medizinische vorrichtung
EP2054537A2 (de) 2006-08-02 2009-05-06 Boston Scientific Scimed, Inc. Endoprothese mit dreidimensionaler desintegrationssteuerung
US8952123B1 (en) * 2006-08-02 2015-02-10 Abbott Cardiovascular Systems Inc. Dioxanone-based copolymers for implantable devices
US8092821B2 (en) * 2006-08-25 2012-01-10 Boston Scientific Scimed, Inc. Medical devices having polymeric regions with improved adhesion
US20080177371A1 (en) * 2006-08-28 2008-07-24 Cornova, Inc. Implantable devices and methods of forming the same
CA2662808A1 (en) 2006-09-14 2008-03-20 Boston Scientific Limited Medical devices with drug-eluting coating
EP2210625B8 (de) 2006-09-15 2012-02-29 Boston Scientific Scimed, Inc. Biologisch erodierbare Endoprothese mit biostabilen anorganischen Schichten
JP2010503494A (ja) 2006-09-15 2010-02-04 ボストン サイエンティフィック リミテッド 生分解性内部人工器官およびその製造方法
CA2663220A1 (en) 2006-09-15 2008-03-20 Boston Scientific Limited Medical devices and methods of making the same
EP2081616B1 (de) 2006-09-15 2017-11-01 Boston Scientific Scimed, Inc. Bioerodierbare endoprothesen und herstellungsverfahren dafür
US8002821B2 (en) 2006-09-18 2011-08-23 Boston Scientific Scimed, Inc. Bioerodible metallic ENDOPROSTHESES
CA2663717A1 (en) * 2006-09-18 2008-03-27 Boston Scientific Limited Controlling biodegradation of a medical instrument
EP2084310A1 (de) * 2006-10-05 2009-08-05 Boston Scientific Limited Durch plasmaelektrolytische abscheidung gebildete polymerfreie überzüge für medizinische vorrichtungen
US7959942B2 (en) 2006-10-20 2011-06-14 Orbusneich Medical, Inc. Bioabsorbable medical device with coating
CN101631513B (zh) 2006-10-20 2013-06-05 奥巴斯尼茨医学公司 可生物吸收的聚合物组合物和医疗设备
EP2081694B1 (de) * 2006-10-23 2020-05-13 Micell Technologies, Inc. Halter zum elektrischen laden eines substrats während der beschichtung
US9248094B2 (en) * 2006-10-30 2016-02-02 Poly-Med, Inc. Suture-specific coatings for modulated release of bioactive agents
US7981150B2 (en) 2006-11-09 2011-07-19 Boston Scientific Scimed, Inc. Endoprosthesis with coatings
US7939095B2 (en) 2006-12-21 2011-05-10 Cordis Corporation Crosslinked silane coating for medical devices
ES2506144T3 (es) 2006-12-28 2014-10-13 Boston Scientific Limited Endoprótesis bioerosionables y procedimiento de fabricación de las mismas
US11426494B2 (en) 2007-01-08 2022-08-30 MT Acquisition Holdings LLC Stents having biodegradable layers
JP5603598B2 (ja) 2007-01-08 2014-10-08 ミセル テクノロジーズ、インコーポレイテッド 生物分解層を有するステント
US8221496B2 (en) 2007-02-01 2012-07-17 Cordis Corporation Antithrombotic and anti-restenotic drug eluting stent
WO2008101008A1 (en) * 2007-02-13 2008-08-21 Cv Therapeutics, Inc. Use of ranolazine for the treatment of coronary microvascular diseases
EP2117509A1 (de) * 2007-02-13 2009-11-18 CV Therapeutics Inc. Verwendung von ranolazin zur behandlung von herz-kreislauf-erkrankungen
US20090111826A1 (en) * 2007-02-13 2009-04-30 Louis Lange Use of ranolazine for the treatment of cardiovascular diseases
US20080193530A1 (en) * 2007-02-13 2008-08-14 Brent Blackburn Use of ranolazine for the treatment of non-coronary microvascular diseases
US8431149B2 (en) 2007-03-01 2013-04-30 Boston Scientific Scimed, Inc. Coated medical devices for abluminal drug delivery
US8070797B2 (en) 2007-03-01 2011-12-06 Boston Scientific Scimed, Inc. Medical device with a porous surface for delivery of a therapeutic agent
CA2680229A1 (en) * 2007-03-09 2008-09-18 Jay S. Yadav Bioabsorbable coatings for medical devices
US20080233191A1 (en) * 2007-03-22 2008-09-25 Brent Blackburn Use of ranolazine for elevated brain-type natriuretic peptide
US8067054B2 (en) 2007-04-05 2011-11-29 Boston Scientific Scimed, Inc. Stents with ceramic drug reservoir layer and methods of making and using the same
US20100211164A1 (en) * 2007-04-17 2010-08-19 Mcclain James B Stents having biodegradable layers
US7976915B2 (en) 2007-05-23 2011-07-12 Boston Scientific Scimed, Inc. Endoprosthesis with select ceramic morphology
US8084077B2 (en) 2007-05-25 2011-12-27 Abbott Laboratories One-step phosphorylcholine-linked polymer coating and drug loading of stent
EP2170418B1 (de) 2007-05-25 2016-03-16 Micell Technologies, Inc. Polymerfilme zur beschichtung von medizinprodukten
EP2170333B1 (de) * 2007-05-31 2013-02-20 Gilead Sciences, Inc. Ranolazin für erhöhtes natriuretisches peptid vom gehirn-typ
US8293260B2 (en) * 2007-06-05 2012-10-23 Abbott Cardiovascular Systems Inc. Elastomeric copolymer coatings containing poly (tetramethyl carbonate) for implantable medical devices
US8263104B2 (en) * 2007-06-08 2012-09-11 Northwestern University Polymer nanofilm coatings
US8133553B2 (en) 2007-06-18 2012-03-13 Zimmer, Inc. Process for forming a ceramic layer
KR101023164B1 (ko) * 2007-06-19 2011-03-18 (주)바이오니아 화학물질로 코팅된 금도금 스텐트, 올리고뉴클레오타이드를 바인딩시킨 금도금 스텐트 및 이들의제조방법
US8309521B2 (en) 2007-06-19 2012-11-13 Zimmer, Inc. Spacer with a coating thereon for use with an implant device
US20090004243A1 (en) 2007-06-29 2009-01-01 Pacetti Stephen D Biodegradable triblock copolymers for implantable devices
US7942926B2 (en) 2007-07-11 2011-05-17 Boston Scientific Scimed, Inc. Endoprosthesis coating
US8002823B2 (en) 2007-07-11 2011-08-23 Boston Scientific Scimed, Inc. Endoprosthesis coating
EP2187988B1 (de) 2007-07-19 2013-08-21 Boston Scientific Limited Endoprothese mit nicht verschmutzender oberfläche
US8815273B2 (en) 2007-07-27 2014-08-26 Boston Scientific Scimed, Inc. Drug eluting medical devices having porous layers
US7931683B2 (en) 2007-07-27 2011-04-26 Boston Scientific Scimed, Inc. Articles having ceramic coated surfaces
WO2009018340A2 (en) 2007-07-31 2009-02-05 Boston Scientific Scimed, Inc. Medical device coating by laser cladding
EP2185103B1 (de) 2007-08-03 2014-02-12 Boston Scientific Scimed, Inc. Überzug für ein medizinprodukt mit vergrösserter oberfläche
US8409272B2 (en) 2007-09-04 2013-04-02 Japan Stent Technology Co., Ltd. Sustained drug-releasing stent
US8052745B2 (en) 2007-09-13 2011-11-08 Boston Scientific Scimed, Inc. Endoprosthesis
WO2009041691A1 (ja) 2007-09-28 2009-04-02 Terumo Kabushiki Kaisha 生体内留置物
US8608049B2 (en) 2007-10-10 2013-12-17 Zimmer, Inc. Method for bonding a tantalum structure to a cobalt-alloy substrate
US8080223B2 (en) * 2007-10-19 2011-12-20 Biointraface, Inc. Method of making a composite from metal oxide and polymer precursors
WO2009051780A1 (en) * 2007-10-19 2009-04-23 Micell Technologies, Inc. Drug coated stents
US8661630B2 (en) 2008-05-21 2014-03-04 Abbott Cardiovascular Systems Inc. Coating comprising an amorphous primer layer and a semi-crystalline reservoir layer
US20100298925A1 (en) * 2007-10-31 2010-11-25 Chameleon Scientific Corporation Spinulose metal surfaces
US20090287302A1 (en) * 2008-05-16 2009-11-19 Chameleon Scientific Corporation Polymer coated spinulose metal surfaces
US8158216B2 (en) * 2007-10-31 2012-04-17 Metascape Llc Spinulose titanium nanoparticulate surfaces
US20090110713A1 (en) * 2007-10-31 2009-04-30 Florencia Lim Biodegradable polymeric materials providing controlled release of hydrophobic drugs from implantable devices
US20090118813A1 (en) * 2007-11-02 2009-05-07 Torsten Scheuermann Nano-patterned implant surfaces
US20090118809A1 (en) * 2007-11-02 2009-05-07 Torsten Scheuermann Endoprosthesis with porous reservoir and non-polymer diffusion layer
US7938855B2 (en) 2007-11-02 2011-05-10 Boston Scientific Scimed, Inc. Deformable underlayer for stent
US8029554B2 (en) 2007-11-02 2011-10-04 Boston Scientific Scimed, Inc. Stent with embedded material
US8216632B2 (en) 2007-11-02 2012-07-10 Boston Scientific Scimed, Inc. Endoprosthesis coating
US20090143855A1 (en) * 2007-11-29 2009-06-04 Boston Scientific Scimed, Inc. Medical Device Including Drug-Loaded Fibers
EP2224991B1 (de) 2007-11-30 2018-02-21 Cook Medical Technologies LLC Verfahren und vorrichtung für die gefässtherapie
US20100008970A1 (en) * 2007-12-14 2010-01-14 Boston Scientific Scimed, Inc. Drug-Eluting Endoprosthesis
BRPI0906702A2 (pt) * 2008-01-09 2015-06-30 Innovative Health Technologies Llc Grânulos de implante e métodos para realizar a regeneração e preservação óssea
US20090192583A1 (en) * 2008-01-28 2009-07-30 Medtronic Vascular, Inc. Ordered Coatings for Drug Eluting Stents and Medical Devices
JP5806466B2 (ja) 2008-01-28 2015-11-10 バイオメット・３アイ・エルエルシー 親水性を向上させたインプラント表面
WO2009095975A1 (ja) * 2008-01-31 2009-08-06 Menicon Co., Ltd. 医療機器の製造方法
US9603980B2 (en) * 2008-02-26 2017-03-28 CARDINAL HEALTH SWITZERLAND 515 GmbH Layer-by-layer stereocomplexed polymers as drug depot carriers or coatings in medical devices
SG192523A1 (en) * 2008-04-17 2013-08-30 Micell Technologies Inc Stents having bioabsorbable layers
WO2009131911A2 (en) 2008-04-22 2009-10-29 Boston Scientific Scimed, Inc. Medical devices having a coating of inorganic material
WO2009132176A2 (en) 2008-04-24 2009-10-29 Boston Scientific Scimed, Inc. Medical devices having inorganic particle layers
US7998192B2 (en) 2008-05-09 2011-08-16 Boston Scientific Scimed, Inc. Endoprostheses
US8697113B2 (en) * 2008-05-21 2014-04-15 Abbott Cardiovascular Systems Inc. Coating comprising a terpolymer comprising caprolactone and glycolide
US10799593B2 (en) 2008-06-09 2020-10-13 Northwestern University Nanodiamond particle complexes
US20100040672A1 (en) * 2008-06-09 2010-02-18 Northwestern University Delivery of therapeutics
US8236046B2 (en) 2008-06-10 2012-08-07 Boston Scientific Scimed, Inc. Bioerodible endoprosthesis
IL192262A (en) 2008-06-17 2016-05-31 Z H T Eng Equipment And Tech Ltd A polymer that releases drugs into the animal body, a medicinal product containing it and a method for its preparation
EP2303350A2 (de) 2008-06-18 2011-04-06 Boston Scientific Scimed, Inc. Endoprothesen-beschichtung
US10898620B2 (en) 2008-06-20 2021-01-26 Razmodics Llc Composite stent having multi-axial flexibility and method of manufacture thereof
US8206635B2 (en) 2008-06-20 2012-06-26 Amaranth Medical Pte. Stent fabrication via tubular casting processes
US8206636B2 (en) 2008-06-20 2012-06-26 Amaranth Medical Pte. Stent fabrication via tubular casting processes
US20100004733A1 (en) * 2008-07-02 2010-01-07 Boston Scientific Scimed, Inc. Implants Including Fractal Structures
CN102159257B (zh) 2008-07-17 2015-11-25 米歇尔技术公司 药物递送医疗设备
US7985252B2 (en) 2008-07-30 2011-07-26 Boston Scientific Scimed, Inc. Bioerodible endoprosthesis
US8642063B2 (en) * 2008-08-22 2014-02-04 Cook Medical Technologies Llc Implantable medical device coatings with biodegradable elastomer and releasable taxane agent
US9220811B2 (en) * 2008-09-22 2015-12-29 Boston Scientific Scimed, Inc. Implantable or insertable medical devices
US8076529B2 (en) 2008-09-26 2011-12-13 Abbott Cardiovascular Systems, Inc. Expandable member formed of a fibrous matrix for intraluminal drug delivery
US8226603B2 (en) 2008-09-25 2012-07-24 Abbott Cardiovascular Systems Inc. Expandable member having a covering formed of a fibrous matrix for intraluminal drug delivery
US8049061B2 (en) 2008-09-25 2011-11-01 Abbott Cardiovascular Systems, Inc. Expandable member formed of a fibrous matrix having hydrogel polymer for intraluminal drug delivery
US8382824B2 (en) 2008-10-03 2013-02-26 Boston Scientific Scimed, Inc. Medical implant having NANO-crystal grains with barrier layers of metal nitrides or fluorides
GB0819296D0 (en) * 2008-10-21 2008-11-26 Smith & Nephew Coating II
US8231980B2 (en) 2008-12-03 2012-07-31 Boston Scientific Scimed, Inc. Medical implants including iridium oxide
US8834913B2 (en) * 2008-12-26 2014-09-16 Battelle Memorial Institute Medical implants and methods of making medical implants
WO2010088682A2 (en) * 2009-02-02 2010-08-05 Medtronic, Inc. Composite antimicrobial accessory including a membrane layer and a porous layer
US8222360B2 (en) 2009-02-13 2012-07-17 Visiogen, Inc. Copolymers for intraocular lens systems
EP2403546A2 (de) 2009-03-02 2012-01-11 Boston Scientific Scimed, Inc. Selbstpufferende medizinische implantate
JP5597625B2 (ja) * 2009-03-02 2014-10-01 株式会社日本ステントテクノロジー 薬剤溶出性ステント
US8071156B2 (en) 2009-03-04 2011-12-06 Boston Scientific Scimed, Inc. Endoprostheses
US20100241220A1 (en) * 2009-03-23 2010-09-23 Mcclain James B Peripheral Stents Having Layers
CA2757276C (en) * 2009-04-01 2017-06-06 Micell Technologies, Inc. Coated stents
CA2759015C (en) 2009-04-17 2017-06-20 James B. Mcclain Stents having controlled elution
US20100273696A1 (en) * 2009-04-23 2010-10-28 Herbert Hopfstock Composition and method for the prevention and removal of unwanted paint on a surface
US20100274352A1 (en) * 2009-04-24 2010-10-28 Boston Scientific Scrimed, Inc. Endoprosthesis with Selective Drug Coatings
US8287937B2 (en) 2009-04-24 2012-10-16 Boston Scientific Scimed, Inc. Endoprosthese
US20100278895A1 (en) * 2009-04-30 2010-11-04 Medtronic, Inc. Antioxidants and antimicrobial accessories including antioxidants
US8697110B2 (en) 2009-05-14 2014-04-15 Abbott Cardiovascular Systems Inc. Polymers comprising amorphous terpolymers and semicrystalline blocks
EP2432425B1 (de) * 2009-05-20 2018-08-08 480 Biomedical, Inc. Medizinisches implantat
US8888840B2 (en) * 2009-05-20 2014-11-18 Boston Scientific Scimed, Inc. Drug eluting medical implant
US9309347B2 (en) 2009-05-20 2016-04-12 Biomedical, Inc. Bioresorbable thermoset polyester/urethane elastomers
US8992601B2 (en) 2009-05-20 2015-03-31 480 Biomedical, Inc. Medical implants
US20110319987A1 (en) * 2009-05-20 2011-12-29 Arsenal Medical Medical implant
US9265633B2 (en) 2009-05-20 2016-02-23 480 Biomedical, Inc. Drug-eluting medical implants
US9388275B2 (en) * 2009-06-01 2016-07-12 International Business Machines Corporation Method of ring-opening polymerization, and related compositions and articles
US20110166251A1 (en) * 2009-07-14 2011-07-07 Karen Hoi Man Wong Polymeric based and surface treated metallic hybrid materials and fabrication methods thereof
EP2453834A4 (de) 2009-07-16 2014-04-16 Micell Technologies Inc Medizinische wirkstofffreisetzungsvorrichtung
US8119704B2 (en) * 2009-07-21 2012-02-21 Abbott Cardiovascular Systems Inc. Implantable medical device comprising copolymer of L-lactide with improved fracture toughness
US20110022158A1 (en) * 2009-07-22 2011-01-27 Boston Scientific Scimed, Inc. Bioerodible Medical Implants
ES2387115B1 (es) * 2009-09-24 2013-07-03 Universitat Politècnica De Catalunya Nuevos polimeros proteicos recombinantes y metodo de bioactivacion de superficies con dichos polimeros
KR101107223B1 (ko) * 2009-11-10 2012-01-25 한국과학기술연구원 금속 기판에 대한 고분자의 코팅 접착력을 향상시키기 위한 나노 커플링
EP2338534A2 (de) * 2009-12-21 2011-06-29 Biotronik VI Patent AG Medizinisches Implantat, Beschichtungsverfahren sowie Implantationsverfahren
EP2531140B1 (de) * 2010-02-02 2017-11-01 Micell Technologies, Inc. Stent und stenteinsatzsystem mit verbesserter einsetzbarkeit
WO2011119536A1 (en) 2010-03-22 2011-09-29 Abbott Cardiovascular Systems Inc. Stent delivery system having a fibrous matrix covering with improved stent retention
US8668732B2 (en) 2010-03-23 2014-03-11 Boston Scientific Scimed, Inc. Surface treated bioerodible metal endoprostheses
US8795762B2 (en) 2010-03-26 2014-08-05 Battelle Memorial Institute System and method for enhanced electrostatic deposition and surface coatings
US8641418B2 (en) 2010-03-29 2014-02-04 Biomet 3I, Llc Titanium nano-scale etching on an implant surface
CA2797110C (en) 2010-04-22 2020-07-21 Micell Technologies, Inc. Stents and other devices having extracellular matrix coating
WO2011138689A2 (en) * 2010-05-03 2011-11-10 Izhar Halahmi Releasing device for administering a bio-active agent
US20110311601A1 (en) * 2010-06-22 2011-12-22 Michael Kleine Antimicrobial medical devices
WO2012009684A2 (en) 2010-07-16 2012-01-19 Micell Technologies, Inc. Drug delivery medical device
CN102008751B (zh) * 2010-11-24 2014-01-08 北京道淼浩博科技发展有限公司 一种生物降解支架复合材料及其制备方法
US20120158123A1 (en) * 2010-12-15 2012-06-21 Biotronik Ag Polymer stent
US8911427B2 (en) 2010-12-28 2014-12-16 Medtronic, Inc. Therapeutic agent reservoir delivery system
KR101770827B1 (ko) * 2011-03-10 2017-08-23 서울대학교산학협력단 혈관내피 전구세포를 선택적으로 포획할 수 있는 스텐트 및 이의 제조 방법
US10464100B2 (en) 2011-05-31 2019-11-05 Micell Technologies, Inc. System and process for formation of a time-released, drug-eluting transferable coating
CA2841360A1 (en) 2011-07-15 2013-01-24 Micell Technologies, Inc. Drug delivery medical device
CN103045161B (zh) * 2011-10-11 2016-03-30 北京格加纳米技术有限公司 一种有机物表面修饰的金属和金属氧化物材料及其制造方法
US10188772B2 (en) 2011-10-18 2019-01-29 Micell Technologies, Inc. Drug delivery medical device
WO2013123509A1 (en) * 2012-02-17 2013-08-22 Bacterin International, Inc. Adjustable bioactive agent dispersion within a polymeric coating
US9131995B2 (en) 2012-03-20 2015-09-15 Biomet 3I, Llc Surface treatment for an implant surface
CN102772831A (zh) * 2012-08-20 2012-11-14 道淼科技(北京)有限公司 一种可降解载药支架
JP6247216B2 (ja) 2012-09-10 2017-12-13 住友ゴム工業株式会社 表面改質方法及び表面改質弾性体
CN103785066B (zh) * 2012-11-01 2015-04-15 中国科学院上海硅酸盐研究所 I型胶原改性的多孔钛涂层及其制备方法
JP5620456B2 (ja) 2012-11-20 2014-11-05 住友ゴム工業株式会社 表面改質方法及び表面改質弾性体
JP6053482B2 (ja) 2012-11-30 2016-12-27 住友ゴム工業株式会社 注射器用ガスケットの製造方法
WO2014165264A1 (en) 2013-03-12 2014-10-09 Micell Technologies, Inc. Bioabsorbable biomedical implants
JP5816222B2 (ja) 2013-04-25 2015-11-18 住友ゴム工業株式会社 表面改質方法及び表面改質弾性体
EP2996629B1 (de) 2013-05-15 2021-09-22 Micell Technologies, Inc. Bioabsorbierbare biomedizinische implantate
JP5797239B2 (ja) 2013-06-11 2015-10-21 住友ゴム工業株式会社 立体形状物の表面改質方法及び注射器用ガスケット
CN105263995B (zh) 2013-06-20 2019-05-28 住友橡胶工业株式会社 表面改性方法和表面改性体
JP5820489B2 (ja) 2014-01-06 2015-11-24 住友ゴム工業株式会社 表面改質方法及び表面改質弾性体
US11292924B2 (en) * 2014-04-08 2022-04-05 Silcotek Corp. Thermal chemical vapor deposition coated article and process
JP6371165B2 (ja) * 2014-09-02 2018-08-08 住友ゴム工業株式会社 金属医療用具
JP6338504B2 (ja) 2014-10-02 2018-06-06 住友ゴム工業株式会社 表面改質方法及び表面改質弾性体
CN107106309B (zh) * 2014-10-28 2019-11-08 株式会社Jimro 药物洗脱支架
WO2016196633A1 (en) * 2015-06-01 2016-12-08 William Marsh Rice University Surface coating method to improve implantable device biocompatibility
JP6551022B2 (ja) 2015-08-03 2019-07-31 住友ゴム工業株式会社 表面改質方法及び表面改質体
JP6613692B2 (ja) 2015-08-03 2019-12-04 住友ゴム工業株式会社 表面改質方法及び表面改質弾性体
US10668259B2 (en) 2015-10-21 2020-06-02 Materials Science Associates, LLC Metal oxide and polymer controlled delivery systems, sunscreens, treatments, and topical coating applicators
US10898617B2 (en) * 2017-01-21 2021-01-26 Biocrede Inc. Medical products and methods configured for controlled release of nitric oxide
CN110267706B (zh) * 2017-02-09 2023-06-20 Med-El电气医疗器械有限公司 与电极载体一起使用的地塞米松涂层
JP7011237B2 (ja) 2017-05-12 2022-01-26 住友ゴム工業株式会社 ポリマー含浸基材樹脂の製造方法
CN110438455A (zh) * 2018-05-02 2019-11-12 南京理工大学 聚乳酸基环丙沙星抗菌薄膜的制备方法
WO2021041505A1 (en) * 2019-08-26 2021-03-04 Forman, Mervyn B. Medical devices for continuous delivery of therapeutic agents
KR102407468B1 (ko) * 2021-11-30 2022-06-10 주식회사 파인트코리아 스텐트 제조용 생분해성 복합소재 조성물 및 이의 제조 방법

Family Cites Families (56)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4104296A (en) * 1970-09-28 1978-08-01 Union Carbide Corporation Organofunctional silicon compounds
DE2746006A1 (de) * 1977-10-13 1979-04-19 Veba Chemie Ag Verfahren zum beschichten von glasoberflaechen
US4215165A (en) * 1978-07-17 1980-07-29 Chemische Werke Huls Aktiengesellschaft Method for coating of glass surfaces
US4591652A (en) * 1985-04-12 1986-05-27 Scm Corporation Polyhydroxyl silanes or siloxanes
US4733665C2 (en) * 1985-11-07 2002-01-29 Expandable Grafts Partnership Expandable intraluminal graft and method and apparatus for implanting an expandable intraluminal graft
US4800882A (en) * 1987-03-13 1989-01-31 Cook Incorporated Endovascular stent and delivery system
US5527337A (en) * 1987-06-25 1996-06-18 Duke University Bioabsorbable stent and method of making the same
US4886062A (en) * 1987-10-19 1989-12-12 Medtronic, Inc. Intravascular radially expandable stent and method of implant
US4916193A (en) * 1987-12-17 1990-04-10 Allied-Signal Inc. Medical devices fabricated totally or in part from copolymers of recurring units derived from cyclic carbonates and lactides
US5019096A (en) * 1988-02-11 1991-05-28 Trustees Of Columbia University In The City Of New York Infection-resistant compositions, medical devices and surfaces and methods for preparing and using same
EP0342830B1 (de) * 1988-05-17 1995-01-11 Dow Corning Limited Organosiliziumverbindungen
US5262451A (en) 1988-06-08 1993-11-16 Cardiopulmonics, Inc. Multifunctional thrombo-resistant coatings and methods of manufacture
US5053048A (en) * 1988-09-22 1991-10-01 Cordis Corporation Thromboresistant coating
US4994071A (en) * 1989-05-22 1991-02-19 Cordis Corporation Bifurcating stent apparatus and method
US5304121A (en) * 1990-12-28 1994-04-19 Boston Scientific Corporation Drug delivery system making use of a hydrogel polymer coating
US5545208A (en) * 1990-02-28 1996-08-13 Medtronic, Inc. Intralumenal drug eluting prosthesis
EP0484057A3 (en) 1990-11-02 1993-04-21 The Dow Chemical Company Antithrombogenic surfaces, their preparation, and materials therefore
US5221698A (en) * 1991-06-27 1993-06-22 The Regents Of The University Of Michigan Bioactive composition
US5464650A (en) * 1993-04-26 1995-11-07 Medtronic, Inc. Intravascular stent and method
IL112873A (en) * 1994-03-08 2005-03-20 Wyeth Corp Rapamycin-fkbp12 binding proteins, their isolation and their use
AU692252B2 (en) * 1994-04-15 1998-06-04 Cobe Cardiovascular, Inc. Biocompatible coated article
US5649977A (en) * 1994-09-22 1997-07-22 Advanced Cardiovascular Systems, Inc. Metal reinforced polymer stent
CA2135846A1 (en) * 1994-11-15 1996-05-16 Alexander Henderson Cross-linkable polymer composition containing a lactone moiety as a catalyst
US5637113A (en) 1994-12-13 1997-06-10 Advanced Cardiovascular Systems, Inc. Polymer film for wrapping a stent structure
US6017577A (en) * 1995-02-01 2000-01-25 Schneider (Usa) Inc. Slippery, tenaciously adhering hydrophilic polyurethane hydrogel coatings, coated polymer substrate materials, and coated medical devices
US5820917A (en) * 1995-06-07 1998-10-13 Medtronic, Inc. Blood-contacting medical device and method
US5866702A (en) * 1996-08-02 1999-02-02 Cv Therapeutics, Incorporation Purine inhibitors of cyclin dependent kinase 2
US6013855A (en) * 1996-08-06 2000-01-11 United States Surgical Grafting of biocompatible hydrophilic polymers onto inorganic and metal surfaces
AUPO251096A0 (en) * 1996-09-23 1996-10-17 Cardiac Crc Nominees Pty Limited Polysiloxane-containing polyurethane elastomeric compositions
DE19640364A1 (de) * 1996-09-30 1998-04-02 Basf Ag Topische Mittel zur Prophylaxe oder Behandlung bakterieller Hautinfektionen
US5786022A (en) * 1996-10-31 1998-07-28 Ethicon, Inc. Coating mixture for surgical articles
US5980551A (en) * 1997-02-07 1999-11-09 Endovasc Ltd., Inc. Composition and method for making a biodegradable drug delivery stent
US5977204A (en) * 1997-04-11 1999-11-02 Osteobiologics, Inc. Biodegradable implant material comprising bioactive ceramic
US6211249B1 (en) 1997-07-11 2001-04-03 Life Medical Sciences, Inc. Polyester polyether block copolymers
CA2298543A1 (en) 1997-08-13 1999-02-25 James Barry Loading and release of water-insoluble drugs
US6485514B1 (en) 1997-12-12 2002-11-26 Supergen, Inc. Local delivery of therapeutic agents
CA2314980A1 (en) * 1997-12-19 1999-07-01 Smithkline Beecham Corporation Compounds of heteroaryl substituted imidazole, their pharmaceutical compositions and uses
ES2179646T3 (es) 1998-04-27 2003-01-16 Surmodics Inc Revestimiento que libera un agente bioactivo.
US6001945A (en) * 1998-07-15 1999-12-14 Dow Corning Corporation Hyperbranched polymers containing silicon atoms
US5997954A (en) * 1998-07-15 1999-12-07 Dow Corning Corporation Method of rendering substrates water repellent using hyperbranched polymers containing silicon atoms
US6248127B1 (en) 1998-08-21 2001-06-19 Medtronic Ave, Inc. Thromboresistant coated medical device
US6335029B1 (en) * 1998-08-28 2002-01-01 Scimed Life Systems, Inc. Polymeric coatings for controlled delivery of active agents
US6342591B1 (en) * 1998-09-22 2002-01-29 Biosurface Engineering Technologies, Inc. Amphipathic coating for modulating cellular adhesion composition and methods
US6187024B1 (en) * 1998-11-10 2001-02-13 Target Therapeutics, Inc. Bioactive coating for vaso-occlusive devices
US6120847A (en) * 1999-01-08 2000-09-19 Scimed Life Systems, Inc. Surface treatment method for stent coating
AU767533B2 (en) 1999-01-27 2003-11-13 Compumedics Limited Vigilance monitoring system
TR200102714T2 (tr) 1999-02-01 2002-01-21 Cv Therapeutics, Inc. Sikline bağımlı kinaz 2 ve IkB-&'nın pürün inhibitörleri
US6214807B1 (en) * 1999-06-22 2001-04-10 Cv Therapeutics, Inc. C-pyrazole 2A A receptor agonists
US6521431B1 (en) * 1999-06-22 2003-02-18 Access Pharmaceuticals, Inc. Biodegradable cross-linkers having a polyacid connected to reactive groups for cross-linking polymer filaments
BR0011853A (pt) 1999-06-22 2002-04-30 Cv Therapeutics Inc Agonistas de receptor a2a de tiofeno
US6180615B1 (en) * 1999-06-22 2001-01-30 Cv Therapeutics, Inc. Propargyl phenyl ether A2A receptor agonists
US6403567B1 (en) 1999-06-22 2002-06-11 Cv Therapeutics, Inc. N-pyrazole A2A adenosine receptor agonists
US6258121B1 (en) * 1999-07-02 2001-07-10 Scimed Life Systems, Inc. Stent coating
MXPA03008888A (es) * 2001-03-29 2005-03-07 Vertex Pharma Inhibidores de n-terminal c-jun cinasas (jnk) y otras proteinas cinasas.
US6641611B2 (en) * 2001-11-26 2003-11-04 Swaminathan Jayaraman Therapeutic coating for an intravascular implant
US20030077310A1 (en) * 2001-10-22 2003-04-24 Chandrashekhar Pathak Stent coatings containing HMG-CoA reductase inhibitors

Also Published As

Publication number Publication date
US7160592B2 (en) 2007-01-09
US7364768B2 (en) 2008-04-29
EP1492581A1 (de) 2005-01-05
AU2008243209A1 (en) 2008-12-04
AU2003215495B2 (en) 2008-08-14
CA2476431A1 (en) 2003-08-21
JP2005516736A (ja) 2005-06-09
IL163535A0 (en) 2005-12-18
PL371517A1 (en) 2005-06-27
US20070071926A1 (en) 2007-03-29
MXPA04007898A (es) 2005-06-20
SI1492581T1 (sl) 2007-04-30
DE60310540T2 (de) 2007-10-04
DE60310540D1 (de) 2007-02-01
RU2308976C2 (ru) 2007-10-27
PT1492581E (pt) 2007-02-28
ZA200406448B (en) 2006-05-31
DK1764118T3 (da) 2010-11-08
US7419709B2 (en) 2008-09-02
EP1764118A2 (de) 2007-03-21
ES2349424T3 (es) 2011-01-03
HK1072205A1 (en) 2005-08-19
CN1633313A (zh) 2005-06-29
PT1764118E (pt) 2010-09-27
US20080160166A1 (en) 2008-07-03
HK1107286A1 (en) 2008-04-03
AU2003215495A1 (en) 2003-09-04
NZ534682A (en) 2006-10-27
SI1764118T1 (sl) 2010-11-30
ES2276084T3 (es) 2007-06-16
JP4472348B2 (ja) 2010-06-02
EP1764118A3 (de) 2008-06-25
CY1107549T1 (el) 2013-03-13
RU2004124718A (ru) 2005-04-10
US20070071879A1 (en) 2007-03-29
KR20040097126A (ko) 2004-11-17
NO20043843L (no) 2004-09-14
WO2003068289A1 (en) 2003-08-21
EP1764118B1 (de) 2010-08-25
CN1911460A (zh) 2007-02-14
CN1279984C (zh) 2006-10-18
EP1492581B1 (de) 2006-12-20
US20030219562A1 (en) 2003-11-27
DK1492581T3 (da) 2007-04-30
HUP0402591A2 (hu) 2005-09-28
ATE348643T1 (de) 2007-01-15
ATE478696T1 (de) 2010-09-15

Similar Documents

Publication Publication Date Title
ATE348643T1 (de) Polymerüberzug für medizinische vorrichtungen
ATE317711T1 (de) Elektropolymerisierbare monomere und polymerbeschichtungen auf implantierbaren geräten
DE60328608D1 (de) Polyacrylat-oberflächenschicht für implantierbare medizinische vorrichtungen
CA2444844A1 (en) Medical devices having durable and lubricious polymeric coating
ATE440624T1 (de) Polymerüberzug für medizinische vorrichtungen
PT1175148E (pt) Polimeros resistentes a infeccoes sua preparacao e utilizacoes
ATE305803T1 (de) Wirkstofffreisetzung mit hilfe von therapeutischen hydrogelen
EP1785146A3 (de) Mr-signalaussendende Beschichtungen
BR9910056A (pt) Artigos orgânicos
BR0212436A (pt) Dispositivos biomédicos contendo agentes umectantes internos
DE60333566D1 (de) Medizinische vorrichtung mit verbesserter haftung zwischen einem polymeren berzug und einem substrat
ATE460437T1 (de) Polymere von fluormonomeren und hydrophilen monomeren
AU2019299A (en) Lubricious hydrophilic coating for an intracorporeal medical device
ATE310450T1 (de) Auslösbares wirkstoffabgabesystem
RU2011124872A (ru) Устройство для введения интраокулярной линзы, содержащее картридж с внутренним покрытием
DE60126544D1 (de) Beschichtung für medizinische Geräte
BR0011612A (pt) Método para tratar a superfìcie de uma lente de contato de hidrogel de silicone
JP2005503186A (ja) 医療装置用潤滑コーティング
ATE519510T1 (de) Antithrombogene und antirestenotische vaskuläre medizinprodukte
ATE467650T1 (de) Biologisch aktive blockcopolymere und damit beschichtete artikel
DE602006011564D1 (de) Beschichtung für medizinische Vorrichtungen mit PI 3-Kinase-Hemmer
EP1579879A3 (de) Beschichtung von medizinischen Gegenständen zur Verwendung mit gasübersättigten Flüssigkeiten
ATE458509T1 (de) Dreiarmige biologisch aktive copolymere und beschichtete implantierbare artikel
DE60216901D1 (de) Beschichtetes biomedizinisches produkt
ATE411342T1 (de) Scfv antikörper gegen krankheiten-assoziierte moleküle