DE60334220D1 - Rationell konstruierte, von chondroitinase b abgeleitete lyasen - Google Patents
Rationell konstruierte, von chondroitinase b abgeleitete lyasenInfo
- Publication number
- DE60334220D1 DE60334220D1 DE60334220T DE60334220T DE60334220D1 DE 60334220 D1 DE60334220 D1 DE 60334220D1 DE 60334220 T DE60334220 T DE 60334220T DE 60334220 T DE60334220 T DE 60334220T DE 60334220 D1 DE60334220 D1 DE 60334220D1
- Authority
- DE
- Germany
- Prior art keywords
- chondroitinase
- inhibiting
- rationally constructed
- relates
- lyases
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
- C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
- C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
- C08B37/0069—Chondroitin-4-sulfate, i.e. chondroitin sulfate A; Dermatan sulfate, i.e. chondroitin sulfate B or beta-heparin; Chondroitin-6-sulfate, i.e. chondroitin sulfate C; Derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/88—Lyases (4.)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/527—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving lyase
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US38550902P | 2002-06-03 | 2002-06-03 | |
| PCT/US2003/017680 WO2003102160A2 (en) | 2002-06-03 | 2003-06-03 | Rationally designed polysaccharide lyases derived from chondroitinase b |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE60334220D1 true DE60334220D1 (de) | 2010-10-28 |
Family
ID=29712183
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE60334220T Expired - Lifetime DE60334220D1 (de) | 2002-06-03 | 2003-06-03 | Rationell konstruierte, von chondroitinase b abgeleitete lyasen |
Country Status (7)
| Country | Link |
|---|---|
| US (4) | US6962699B2 (de) |
| EP (1) | EP1532241B1 (de) |
| AT (1) | ATE481478T1 (de) |
| AU (1) | AU2003243396A1 (de) |
| CA (1) | CA2493509C (de) |
| DE (1) | DE60334220D1 (de) |
| WO (1) | WO2003102160A2 (de) |
Families Citing this family (34)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6566406B1 (en) * | 1998-12-04 | 2003-05-20 | Incept, Llc | Biocompatible crosslinked polymers |
| EP1109919A2 (de) | 1998-08-27 | 2001-06-27 | Massachusetts Institute Of Technology | Von heparinase i und ii abgeleitete heparinasen |
| WO2000065521A2 (en) | 1999-04-23 | 2000-11-02 | Massachusetts Institute Of Technology | System and method for polymer notation |
| JP2003525946A (ja) | 2000-03-08 | 2003-09-02 | マサチューセッツ インスティテュート オブ テクノロジー | ヘパリナーゼｉｉｉおよびその使用 |
| EP1319183B1 (de) | 2000-09-12 | 2009-03-25 | Massachusetts Institute Of Technology | Verfahren und produkte, die mit niedermolekularem heparin assoziiert sind |
| AU2440802A (en) | 2000-10-18 | 2002-04-29 | Massachusetts Inst Technology | Methods and products related to pulmonary delivery of polysaccharides |
| AU2003303301B2 (en) | 2002-05-03 | 2008-08-07 | Massachusetts Institute Of Technology | Delta4,5 glycuronidase and uses thereof |
| WO2004108069A2 (en) | 2002-05-04 | 2004-12-16 | Acorda Therapeutics, Inc. | Compositions and methods for promoting neuronal outgrowth |
| US7508206B2 (en) * | 2002-05-20 | 2009-03-24 | Massachusetts Institute Of Technology | Method for sequence determination using NMR |
| US6962699B2 (en) * | 2002-06-03 | 2005-11-08 | Massachusetts Institute Of Technology | Rationally designed polysaccharide lyases derived from chondroitinase B |
| DE60337009D1 (de) * | 2002-08-15 | 2011-06-16 | Acorda Therapeutics Inc | Chimärisches protein |
| JP4606712B2 (ja) * | 2003-01-08 | 2011-01-05 | マサチューセッツ インスティテュート オブ テクノロジー | ２−ｏスルファターゼ組成物および関連の方法 |
| AU2016204464B2 (en) * | 2003-05-16 | 2018-03-22 | Acorda Therapeutics, Inc. | Proteoglycan degrading mutants for treatment of cns |
| ES2420510T3 (es) * | 2003-05-16 | 2013-08-23 | Acorda Therapeutics, Inc. | Composiciones y métodos para el tratamiento de lesiones del SNC |
| US7959914B2 (en) | 2003-05-16 | 2011-06-14 | Acorda Therapeutics, Inc. | Methods of reducing extravasation of inflammatory cells |
| ES2616749T3 (es) * | 2003-05-16 | 2017-06-14 | Acorda Therapeutics, Inc. | Mutantes degradantes del proteoglucano para el tratamiento del SNC |
| WO2005000219A2 (en) * | 2003-05-28 | 2005-01-06 | The Board Of Trustees Of The University Of Illinois | Composition for blocking hiv binding to dendritic cells and methods of use thereof |
| WO2005087920A2 (en) | 2004-03-10 | 2005-09-22 | Massachusetts Institute Of Technology | Recombinant chondroitinase abc i and uses thereof |
| WO2005111627A2 (en) * | 2004-04-15 | 2005-11-24 | Massachusetts Institute Of Technology | Methods and products related to the improved analysis of carbohydrates |
| US20060127950A1 (en) * | 2004-04-15 | 2006-06-15 | Massachusetts Institute Of Technology | Methods and products related to the improved analysis of carbohydrates |
| WO2005110438A2 (en) * | 2004-04-15 | 2005-11-24 | Massachusetts Institute Of Technology | Methods and products related to the intracellular delivery of polysaccharides |
| CA2566731C (en) | 2004-05-18 | 2012-07-24 | Acorda Therapeutics, Inc. | Methods of purifying chondroitinase and stable formulations thereof |
| WO2006088491A2 (en) | 2004-06-29 | 2006-08-24 | Massachusetts Institute Of Technology | Methods and compositions related to the modulation of intercellular junctions |
| US20060154894A1 (en) * | 2004-09-15 | 2006-07-13 | Massachusetts Institute Of Technology | Biologically active surfaces and methods of their use |
| JP5189985B2 (ja) | 2005-09-26 | 2013-04-24 | アコーダ セラピューティクス、インク． | コンドロイチナーゼａｂｃｉ変異体を用いた組成物およびその使用方法 |
| EP2008096A2 (de) * | 2006-04-03 | 2008-12-31 | Massachusetts Institute of Technology | Glykomische muster für den nachweis von erkrankungen |
| EP2450442B1 (de) | 2006-10-10 | 2017-07-19 | Acorda Therapeutics, Inc. | Zusammensetzungen und verfahren zur verwendung von chondroitinase-abci-mutanten |
| US7842492B2 (en) | 2007-01-05 | 2010-11-30 | Massachusetts Institute Of Technology | Compositions of and methods of using sulfatases from flavobacterium heparinum |
| EP2150616A4 (de) | 2007-05-10 | 2011-07-27 | Univ Arizona | Geregelte antigensynthese und/oder geregelte attenuation zur verbesserung der impfstoff immunogenität und/oder -sicherheit |
| GB0712302D0 (en) * | 2007-06-22 | 2007-08-01 | Cambridge Entpr Ltd | Chrondroitinase polypeptides |
| US20090286289A1 (en) * | 2008-03-10 | 2009-11-19 | Pang Danny Z | Production of Hyaluronate Unsaturated Disaccharides and its Application |
| US9045742B2 (en) * | 2009-05-29 | 2015-06-02 | The Arizona Board Of Regents For And On Behalf Of Arizona State University | Recombinant Edwardsiella bacterium |
| US9796970B1 (en) | 2017-04-24 | 2017-10-24 | Advantek Serum Laboratories Ltd. | Production of high purity chondroitinase ABC |
| CN111593040B (zh) * | 2020-06-20 | 2022-08-30 | 山东大学 | 硫酸皮肤素裂解酶及其应用 |
Family Cites Families (75)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US191587A (en) * | 1877-06-05 | Improvement in piano-forte bridges | ||
| US91472A (en) * | 1869-06-15 | Improvement in plows | ||
| US91471A (en) * | 1869-06-15 | steigmeyer | ||
| US37376A (en) * | 1863-01-06 | Improvement in breech-loading fire-arms | ||
| US204869A (en) * | 1878-06-11 | Improvement in weighing-scales | ||
| US169143A (en) * | 1875-10-26 | Improvement in perforating stamps | ||
| US122793A (en) * | 1872-01-16 | Improvement in air-supplying attachments for stoves | ||
| US8820A (en) * | 1852-03-23 | Improvement in friction-primers for cannon | ||
| US128225A (en) * | 1872-06-25 | Improvement in workmen s time-registers | ||
| US197933A (en) * | 1877-12-11 | Improvement in wood-screws | ||
| US92037A (en) * | 1869-06-29 | Improved shoe-pegging- machine | ||
| US99628A (en) * | 1870-02-08 | Signors to themselves and a | ||
| JPS6031478B2 (ja) | 1978-02-10 | 1985-07-22 | 生化学工業株式会社 | 純コンドロイチナ−ゼｂの製造法 |
| US4341869A (en) | 1980-08-25 | 1982-07-27 | Massachusetts Institute Of Technology | Process for producing heparinase |
| US5169772A (en) | 1988-06-06 | 1992-12-08 | Massachusetts Institute Of Technology | Large scale method for purification of high purity heparinase from flavobacterium heparinum |
| JP2726275B2 (ja) | 1988-08-24 | 1998-03-11 | 生化学工業株式会社 | グリコサミノグリカン分解酵素の精製法 |
| JPH0693836B2 (ja) | 1988-11-25 | 1994-11-24 | 新技術事業団 | バチルス属に属するヘパリナーゼ生産微生物、新規ヘパリナーゼ及びその製法 |
| ZA912770B (en) | 1990-04-16 | 1992-01-29 | Bethesda Eye Inst | Enzymatic disinsertion of vitreous body |
| JPH04270327A (ja) | 1991-02-26 | 1992-09-25 | Fuji Photo Optical Co Ltd | カメラの露出補正装置 |
| JP3110064B2 (ja) | 1991-03-06 | 2000-11-20 | 生化学工業株式会社 | 新規ヘパリチナーゼ、その製造法及びその生産菌 |
| US5262325A (en) | 1991-04-04 | 1993-11-16 | Ibex Technologies, Inc. | Method for the enzymatic neutralization of heparin |
| US5668274A (en) | 1991-04-23 | 1997-09-16 | Akzo Nobel N.V. | Sulfated glycosaminoglycanoid derivatives of the dermatan sulfate and chondroitin sulfate type |
| US5714376A (en) | 1991-10-23 | 1998-02-03 | Massachusetts Institute Of Technology | Heparinase gene from flavobacterium heparinum |
| US6001630A (en) | 1992-06-26 | 1999-12-14 | Seikagaku Kogyo Kabushiki Kaisha (Seikagaku Corporation) | Pharmaceutical compositions of chondroitinase ABC isolated from Proteus vulgaris ATCC 6896 |
| US5496718A (en) | 1992-06-26 | 1996-03-05 | Seikagaku Kogyo Kabushiki Kaisha (Seikagaku Corporation) | Chondroitinase ABC isolated from proteus vulgaris ATCC 6896 |
| US5773277A (en) | 1992-06-26 | 1998-06-30 | Seikagaku Kogyo Kabushiki Kaisha | Crystalline chondroitinase isolated from Proteus vulgaris ATCC 6896 |
| JP3419811B2 (ja) | 1993-02-24 | 2003-06-23 | マルハ株式会社 | コンドロイチナーゼ遺伝子 |
| US5389539A (en) | 1992-11-30 | 1995-02-14 | Massachusetts Institute Of Technology | Purification of heparinase I, II, and III from Flavobacterium heparinum |
| US5578480A (en) | 1993-04-23 | 1996-11-26 | American Cyanamid Company | Methods for the isolation and purification of the recombinantly expressed chondroitinase I and II enzymes from P. vulgaris |
| DE69429576T2 (de) | 1993-09-30 | 2002-08-22 | Seikagaku Kogyo Co Ltd | Dermatansulfatezusammensetzung als antithromotisches mittel |
| WO1995013830A1 (en) | 1993-11-17 | 1995-05-26 | Massachusetts Institute Of Technology | Method for inhibiting angiogenesis using heparinase |
| US5498536A (en) | 1994-04-22 | 1996-03-12 | American Cyanamid Company | Chondroitinase II from Proteus vulgaris |
| US5525500A (en) | 1994-04-22 | 1996-06-11 | American Cyanamid Company | Chromatographic process for the copurification of chondroitinase I and II proteins from Proteus vulgaris |
| WO1995029256A1 (en) | 1994-04-22 | 1995-11-02 | American Cyanamid Company | Chondroitinases i and ii, methods of preparation, and use thereof |
| US5681733A (en) | 1994-06-10 | 1997-10-28 | Ibex Technologies | Nucleic acid sequences and expression systems for heparinase II and heparinase III derived from Flavobacterium heparinum |
| US5619421A (en) | 1994-06-17 | 1997-04-08 | Massachusetts Institute Of Technology | Computer-implemented process and computer system for estimating the three-dimensional shape of a ring-shaped molecule and of a portion of a molecule containing a ring-shaped structure |
| US6093563A (en) | 1994-07-08 | 2000-07-25 | Ibex Technologies R And D, Inc. | Chondroitin lyase enzymes |
| US5997863A (en) | 1994-07-08 | 1999-12-07 | Ibex Technologies R And D, Inc. | Attenuation of wound healing processes |
| US5965507A (en) | 1995-06-08 | 1999-10-12 | Procter & Gamble Company | Cleaning compositions comprising chondroitinase |
| US6217863B1 (en) | 1995-10-30 | 2001-04-17 | Massachusetts Institute Of Technology | Rationally designed polysaccharide lyases derived from heparinase I |
| US5866120A (en) | 1995-11-22 | 1999-02-02 | Advanced Corneal Systems, Inc. | Method for accelerating clearance of hemorrhagic blood from the vitreous humor with hyaluronidase |
| IT1285546B1 (it) | 1996-01-16 | 1998-06-18 | Alfa Wassermann Spa | Uso del dermatano solfato a basso peso molecolare e delle specialita' medicinali che lo contengono nella terapia e nella prevenzione della |
| EP0875253B1 (de) | 1997-05-02 | 2005-04-06 | Seikagaku Corporation | Chondroitinase enthaltende Zusammensetzungen |
| DK0900569T3 (da) | 1997-08-22 | 2003-01-27 | Seikagaku Kogyo Co Ltd | Terapeutisk middel til behandling af herniaramt intervertebral diskus |
| US5968822A (en) | 1997-09-02 | 1999-10-19 | Pecker; Iris | Polynucleotide encoding a polypeptide having heparanase activity and expression of same in transduced cells |
| US6190875B1 (en) | 1997-09-02 | 2001-02-20 | Insight Strategy & Marketing Ltd. | Method of screening for potential anti-metastatic and anti-inflammatory agents using mammalian heparanase as a probe |
| US6378527B1 (en) | 1998-04-08 | 2002-04-30 | Chondros, Inc. | Cell-culture and polymer constructs |
| WO1999058650A1 (en) | 1998-05-13 | 1999-11-18 | Biomarin Pharmaceuticals | Lytic enzymes useful for treating fungal infections |
| JP2000044601A (ja) | 1998-07-29 | 2000-02-15 | Seikagaku Kogyo Co Ltd | 新規ガラクトサミノグリカン |
| WO2000065521A2 (en) | 1999-04-23 | 2000-11-02 | Massachusetts Institute Of Technology | System and method for polymer notation |
| WO2001034781A2 (en) | 1999-11-12 | 2001-05-17 | Biomarin Pharmaceuticals | Lytic enzymes useful for treating fungal infections |
| ATE413886T1 (de) | 1999-11-17 | 2008-11-15 | Biomarin Pharm Inc | Verminderung von angiogenese unter verwendung chondroitinsulfat abbauender enzyme |
| WO2001038399A1 (fr) | 1999-11-24 | 2001-05-31 | Seikagaku Corporation | Procede de traitement des maladies des tissus superficiels |
| JP2004504262A (ja) | 1999-12-02 | 2004-02-12 | アイベックス テクノロジーズ， インコーポレイテッド | 線維芽細胞の増殖の弱毒化 |
| CA2397562A1 (en) | 2000-01-21 | 2001-07-26 | Ibex Pharmaceuticals, Inc. | Flavobacterium heparinum expression system |
| JP2003525946A (ja) | 2000-03-08 | 2003-09-02 | マサチューセッツ インスティテュート オブ テクノロジー | ヘパリナーゼｉｉｉおよびその使用 |
| EP1319183B1 (de) | 2000-09-12 | 2009-03-25 | Massachusetts Institute Of Technology | Verfahren und produkte, die mit niedermolekularem heparin assoziiert sind |
| AU2440802A (en) | 2000-10-18 | 2002-04-29 | Massachusetts Inst Technology | Methods and products related to pulmonary delivery of polysaccharides |
| US20030008820A1 (en) | 2001-03-27 | 2003-01-09 | Massachusetts Institute Of Technology | Methods and products related to FGF dimerization |
| US20040214228A9 (en) | 2001-09-14 | 2004-10-28 | Ganesh Venkataraman | Methods of evaluating glycomolecules for enhanced activities |
| WO2003025133A2 (en) | 2001-09-14 | 2003-03-27 | Mimeon, Inc. | Methods of making glycolmolecules with enhanced activities and uses thereof |
| GB0205022D0 (en) | 2002-03-04 | 2002-04-17 | Univ Cambridge Tech | Materials and methods for the treatment of cns damage |
| WO2003078960A2 (en) | 2002-03-11 | 2003-09-25 | Momenta Pharmaceuticals, Inc. | Analysis of sulfated polysaccharides |
| AU2003225182B2 (en) | 2002-04-25 | 2009-02-26 | Momenta Pharmaceuticals, Inc. | Methods and products for mucosal delivery |
| AU2003303301B2 (en) | 2002-05-03 | 2008-08-07 | Massachusetts Institute Of Technology | Delta4,5 glycuronidase and uses thereof |
| US7508206B2 (en) | 2002-05-20 | 2009-03-24 | Massachusetts Institute Of Technology | Method for sequence determination using NMR |
| US6962699B2 (en) | 2002-06-03 | 2005-11-08 | Massachusetts Institute Of Technology | Rationally designed polysaccharide lyases derived from chondroitinase B |
| WO2004066808A2 (en) | 2002-12-20 | 2004-08-12 | Momenta Pharmaceuticals, Inc. | Glycan markers for diagnosing and monitoring disease |
| JP4606712B2 (ja) | 2003-01-08 | 2011-01-05 | マサチューセッツ インスティテュート オブ テクノロジー | ２−ｏスルファターゼ組成物および関連の方法 |
| KR100846449B1 (ko) * | 2003-03-27 | 2008-07-16 | 삼성전자주식회사 | 휴대용 복합장치의 웹 카메라 모드 설정방법 |
| ES2616749T3 (es) | 2003-05-16 | 2017-06-14 | Acorda Therapeutics, Inc. | Mutantes degradantes del proteoglucano para el tratamiento del SNC |
| WO2005026720A1 (en) | 2003-09-04 | 2005-03-24 | Parivid Llc | Methods and apparatus for characterizing polymeric mixtures |
| US7851223B2 (en) | 2004-02-27 | 2010-12-14 | Roar Holding Llc | Method to detect emphysema |
| JP2007526322A (ja) | 2004-03-02 | 2007-09-13 | マサチューセッツ インスティテュート オブ テクノロジー | ナノセル薬物送達系 |
| CA2566731C (en) | 2004-05-18 | 2012-07-24 | Acorda Therapeutics, Inc. | Methods of purifying chondroitinase and stable formulations thereof |
-
2003
- 2003-06-03 US US10/454,816 patent/US6962699B2/en not_active Expired - Lifetime
- 2003-06-03 EP EP03756399A patent/EP1532241B1/de not_active Expired - Lifetime
- 2003-06-03 WO PCT/US2003/017680 patent/WO2003102160A2/en not_active Application Discontinuation
- 2003-06-03 AT AT03756399T patent/ATE481478T1/de not_active IP Right Cessation
- 2003-06-03 AU AU2003243396A patent/AU2003243396A1/en not_active Abandoned
- 2003-06-03 DE DE60334220T patent/DE60334220D1/de not_active Expired - Lifetime
- 2003-06-03 CA CA002493509A patent/CA2493509C/en not_active Expired - Fee Related
-
2004
- 2004-10-14 US US10/966,671 patent/US7129335B2/en not_active Expired - Lifetime
- 2004-10-14 US US10/967,041 patent/US7105334B2/en not_active Expired - Lifetime
-
2006
- 2006-09-08 US US11/518,389 patent/US20070065424A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| CA2493509C (en) | 2010-03-09 |
| US20070065424A1 (en) | 2007-03-22 |
| US7105334B2 (en) | 2006-09-12 |
| US20050233419A1 (en) | 2005-10-20 |
| EP1532241B1 (de) | 2010-09-15 |
| US6962699B2 (en) | 2005-11-08 |
| CA2493509A1 (en) | 2003-12-11 |
| AU2003243396A1 (en) | 2003-12-19 |
| AU2003243396A8 (en) | 2003-12-19 |
| US7129335B2 (en) | 2006-10-31 |
| WO2003102160A2 (en) | 2003-12-11 |
| US20040091472A1 (en) | 2004-05-13 |
| US20050227320A1 (en) | 2005-10-13 |
| EP1532241A2 (de) | 2005-05-25 |
| WO2003102160A3 (en) | 2004-09-16 |
| EP1532241A4 (de) | 2005-12-14 |
| ATE481478T1 (de) | 2010-10-15 |
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