DE68917040D1 - Heparinderivate und Verfahren zu deren Herstellung. - Google Patents

Heparinderivate und Verfahren zu deren Herstellung.

Info

Publication number
DE68917040D1
DE68917040D1 DE68917040T DE68917040T DE68917040D1 DE 68917040 D1 DE68917040 D1 DE 68917040D1 DE 68917040 T DE68917040 T DE 68917040T DE 68917040 T DE68917040 T DE 68917040T DE 68917040 D1 DE68917040 D1 DE 68917040D1
Authority
DE
Germany
Prior art keywords
heparin derivatives
heparin
heparins
hemorrhagic
activity
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE68917040T
Other languages
English (en)
Other versions
DE68917040T2 (de
Inventor
Silvano Piani
Gianfranco Tamagnone
Raul Roberto Alpino
Maria Rita Milani
Marinella Fantuz
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Alfa Wasserman SpA
Original Assignee
Alfa Wasserman SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alfa Wasserman SpA filed Critical Alfa Wasserman SpA
Application granted granted Critical
Publication of DE68917040D1 publication Critical patent/DE68917040D1/de
Publication of DE68917040T2 publication Critical patent/DE68917040T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
    • C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
    • C08B37/0075—Heparin; Heparan sulfate; Derivatives thereof, e.g. heparosan; Purification or extraction methods thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
DE68917040T 1988-06-10 1989-05-19 Heparinderivate und Verfahren zu deren Herstellung. Expired - Fee Related DE68917040T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT8803504A IT1234508B (it) 1988-06-10 1988-06-10 Derivati eparinici e procedimento per la loro preparazione

Publications (2)

Publication Number Publication Date
DE68917040D1 true DE68917040D1 (de) 1994-09-01
DE68917040T2 DE68917040T2 (de) 1995-01-12

Family

ID=11108618

Family Applications (2)

Application Number Title Priority Date Filing Date
DE68917040T Expired - Fee Related DE68917040T2 (de) 1988-06-10 1989-05-19 Heparinderivate und Verfahren zu deren Herstellung.
DE198989109030T Pending DE347588T1 (de) 1988-06-10 1989-05-19 Heparinderivate und verfahren zu deren herstellung.

Family Applications After (1)

Application Number Title Priority Date Filing Date
DE198989109030T Pending DE347588T1 (de) 1988-06-10 1989-05-19 Heparinderivate und verfahren zu deren herstellung.

Country Status (18)

Country Link
US (1) US5010063A (de)
EP (1) EP0347588B1 (de)
JP (1) JPH0739442B2 (de)
KR (1) KR960015110B1 (de)
AT (1) ATE109164T1 (de)
CA (1) CA1309402C (de)
DE (2) DE68917040T2 (de)
DK (1) DK173818B1 (de)
ES (1) ES2012748T3 (de)
FI (1) FI94534C (de)
GR (1) GR900300018T1 (de)
IE (1) IE64830B1 (de)
IL (1) IL90411A (de)
IT (1) IT1234508B (de)
NO (1) NO174259C (de)
NZ (1) NZ229212A (de)
PT (1) PT90817B (de)
ZA (1) ZA893882B (de)

Families Citing this family (45)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1234508B (it) * 1988-06-10 1992-05-19 Alfa Wassermann Spa Derivati eparinici e procedimento per la loro preparazione
IT1234826B (it) * 1989-01-30 1992-05-29 Alfa Wassermann Spa Derivati eparinici e procedimento per la loro preparazione
US5232040A (en) * 1990-07-12 1993-08-03 Lanxide Technology Company, Lp Method for reducing metal content of self-supporting composite bodies and articles formed thereby
IT1243987B (it) * 1990-10-29 1994-06-28 Derivati Organici Lab Procedimento per la preparazione di epossi-eparidi prodotti ottenuti ecomposizioni farmaceutiche che li contengono
IT1254216B (it) * 1992-02-25 1995-09-14 Opocrin Spa Derivati polisaccaridici di eparina, eparan solfato, loro frazioni e frammenti, procedimento per la loro preparazione e composizioni farmaceutiche che li contengono
IT1260136B (it) * 1992-04-17 1996-03-28 Alfa Wassermann Spa Glicosaminoglicani semisintetici contenenti acido alfa-l-galatturonicosostituito con radicali nucleofili in posizione 3
IT1260137B (it) * 1992-04-17 1996-03-28 Alfa Wassermann Spa Glicosaminoglicani semisintetici a struttura eparinica od eparanica modificati nella posizione 2 dell'acido alfa-l-iduronico-2-0-solfato
US6750207B1 (en) * 1992-05-01 2004-06-15 Yeda Research And Development Co. Ltd. Compositions for the regulation of cytokine activity
US5861382A (en) * 1992-05-01 1999-01-19 Yeda Research And Development Co. Ltd. Methods for regulation of active TNF-α
US5696100A (en) * 1992-12-22 1997-12-09 Glycomed Incorporated Method for controlling O-desulfation of heparin and compositions produced thereby
US5296471A (en) * 1992-12-22 1994-03-22 Glycomed Incorporated Method for controlling o-desulfation of heparin and compositions produced thereby
IT1264102B1 (it) * 1993-03-29 1996-09-10 Alfa Wassermann Spa Processo per la sintesi di glicosaminoglicani semisintetici contenenti acido alfa-l-galatturonico sostituito con radicali
IT1264101B1 (it) * 1993-03-29 1996-09-10 Alfa Wassermann Spa Processo per la sintesi di glicosaminoglicani semisintetici a struttura eparinica od eparanica modificati nella posizione 2
US20020055710A1 (en) * 1998-04-30 2002-05-09 Ronald J. Tuch Medical device for delivering a therapeutic agent and method of preparation
US5744457A (en) * 1995-03-31 1998-04-28 Hamilton Civic Hospitals Research Development Inc. Compositions and methods for inhibiting thrombogenesis
US6001820A (en) * 1995-03-31 1999-12-14 Hamilton Civic Hospitals Research Development Inc. Compositions and methods for inhibiting thrombogenesis
US5763427A (en) * 1995-03-31 1998-06-09 Hamilton Civic Hospitals Research Development Inc. Compositions and methods for inhibiting thrombogenesis
US6217863B1 (en) 1995-10-30 2001-04-17 Massachusetts Institute Of Technology Rationally designed polysaccharide lyases derived from heparinase I
US5767269A (en) * 1996-10-01 1998-06-16 Hamilton Civic Hospitals Research Development Inc. Processes for the preparation of low-affinity, low molecular weight heparins useful as antithrombotics
SK286024B6 (sk) * 1996-11-27 2008-01-07 Aventis Pharmaceuticals Inc. Farmaceutický prostriedok a použitie tohto prostriedku na prípravu liečiva
US6203536B1 (en) 1997-06-17 2001-03-20 Medtronic, Inc. Medical device for delivering a therapeutic substance and method therefor
US6106454A (en) * 1997-06-17 2000-08-22 Medtronic, Inc. Medical device for delivering localized radiation
US6013099A (en) * 1998-04-29 2000-01-11 Medtronic, Inc. Medical device for delivering a water-insoluble therapeutic salt or substance
EP1109919A2 (de) * 1998-08-27 2001-06-27 Massachusetts Institute Of Technology Von heparinase i und ii abgeleitete heparinasen
US7056504B1 (en) 1998-08-27 2006-06-06 Massachusetts Institute Of Technology Rationally designed heparinases derived from heparinase I and II
WO2000065521A2 (en) * 1999-04-23 2000-11-02 Massachusetts Institute Of Technology System and method for polymer notation
BR0012202A (pt) * 1999-06-30 2002-04-02 Hamilton Civic Hospitals Res Composições de heparina de peso molecular médio (mmwh), método de tratamento de uma condição trombótica, método de prevenção da formação de um trombo, método de inibição da formação de trombos, composição farmacêutica, método de tratamento de trombose venosa profunda, método de prevenção de embolia pulmonar, método de preparação e usos de uma composição de mmwh
JP2003525946A (ja) 2000-03-08 2003-09-02 マサチューセッツ インスティテュート オブ テクノロジー ヘパリナーゼｉｉｉおよびその使用
US7259152B2 (en) 2000-06-07 2007-08-21 Alfa Wasserman, Inc. Methods and compositions using sulodexide for the treatment of diabetic nephropathy
AU2001291549A1 (en) * 2000-09-08 2002-03-22 Hamilton Civic Hospitals Research Development Inc. Antithrombotic compositions
EP1319183B1 (de) * 2000-09-12 2009-03-25 Massachusetts Institute Of Technology Verfahren und produkte, die mit niedermolekularem heparin assoziiert sind
AU2440802A (en) * 2000-10-18 2002-04-29 Massachusetts Inst Technology Methods and products related to pulmonary delivery of polysaccharides
US7285536B2 (en) * 2001-12-05 2007-10-23 Yeda Research And Development Co., Ltd. Anti-cancer therapeutic compounds
WO2003078960A2 (en) 2002-03-11 2003-09-25 Momenta Pharmaceuticals, Inc. Analysis of sulfated polysaccharides
ITMI20031679A1 (it) * 2003-08-29 2005-02-28 Opocrin Spa Processo per la produzione di eparine a basso peso
EP1582531A1 (de) 2004-03-24 2005-10-05 Aventis Pharma S.A. Verfahren zur Oxydierung nicht-fraktionierten Heparins und die Detektion der Anwesenheit oder Abwesenheit von Glykoserin in Heparin und in von Heparin abgeleiteten Produkten
US7608246B2 (en) * 2005-09-02 2009-10-27 The Brigham And Women's Hospital, Inc. Apolipoprotein E as an adjuvant for lipid antigens
ATE552004T1 (de) 2005-11-30 2012-04-15 Istituto G Ronzoni Oral verabreichbare heparinderivate
US9139876B1 (en) 2007-05-03 2015-09-22 Momenta Pharmacueticals, Inc. Method of analyzing a preparation of a low molecular weight heparin
CN102791742B (zh) * 2010-01-19 2014-12-24 动量制药公司 评价肝素制剂
KR101847846B1 (ko) * 2010-09-14 2018-04-11 고쿠리츠 다이가쿠 호징 미야자키 다이가쿠 고순도 헤파린 및 그 제조방법
WO2012115952A1 (en) 2011-02-21 2012-08-30 Momenta Pharmaceuticals, Inc. Evaluating heparin preparations
RU2639574C2 (ru) * 2016-05-23 2017-12-21 Алексей Георгиевич Александров Способ получения низкомолекулярного гепарина
WO2022015794A1 (en) 2020-07-14 2022-01-20 Optimvia, Llc Methods for synthesizing non-anticoagulant heparan sulfate
AU2020310172A1 (en) 2019-07-09 2022-03-03 Optimvia Llc Methods for synthesizing anticoagulant polysaccharides

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3065140A (en) * 1958-07-05 1962-11-20 Roussel Uclaf Heparin derivatives and methods of preparing same
US3016331A (en) * 1960-01-28 1962-01-09 Ormonoterapia Richter Spa Purification of heparin
IT1083903B (it) * 1977-08-09 1985-05-25 Lobo Srl Oligo-eteropolisaccaridi con attivita' eparinosimili,procedimento per il loro ottenimento e relative composizioni terapeutiche
IT1195497B (it) * 1983-03-08 1988-10-19 Opocrin Spa Procedimento per la preparazione di frazioni oligosaccaridiche dotate di proprieta' farmacologiche per degradazione chimica di eparina
DE3422518A1 (de) * 1984-06-16 1985-12-19 B. Braun Melsungen Ag, 3508 Melsungen Heparin-derivate, verfahren zu ihrer herstellung, diese enthaltende arzneimittel und ihre verwendung bei der behandlung von fettstoffwechselstoerungen
ES2003197A6 (es) * 1987-01-05 1988-10-16 Rovi Lab Farmaceut Sa Procedimiento de despolimerizacion de la heparina para la obtencion de una heparina de bajo peso molecular dotada de actividad antitrombotica
IT1234508B (it) * 1988-06-10 1992-05-19 Alfa Wassermann Spa Derivati eparinici e procedimento per la loro preparazione

Also Published As

Publication number Publication date
NO892366L (no) 1989-12-11
FI892850A0 (fi) 1989-06-09
NZ229212A (en) 1991-02-26
IE64830B1 (en) 1995-09-06
EP0347588B1 (de) 1994-07-27
DE68917040T2 (de) 1995-01-12
DK285089D0 (da) 1989-06-09
ES2012748T3 (es) 1994-10-16
US5010063A (en) 1991-04-23
NO892366D0 (no) 1989-06-09
DK285089A (da) 1989-12-11
GR900300018T1 (en) 1991-06-07
PT90817B (pt) 1994-11-30
NO174259B (no) 1993-12-27
JPH0264102A (ja) 1990-03-05
DE347588T1 (de) 1990-05-23
AU611028B2 (en) 1991-05-30
PT90817A (pt) 1989-12-29
FI94534C (fi) 1995-09-25
NO174259C (no) 1994-04-06
DK173818B1 (da) 2001-11-19
ATE109164T1 (de) 1994-08-15
KR960015110B1 (ko) 1996-10-28
KR910000771A (ko) 1991-01-30
IT8803504A0 (it) 1988-06-10
JPH0739442B2 (ja) 1995-05-01
IL90411A (en) 1993-05-13
EP0347588A1 (de) 1989-12-27
CA1309402C (en) 1992-10-27
ZA893882B (en) 1990-02-28
AU3512889A (en) 1989-12-14
IL90411A0 (en) 1990-01-18
FI892850A (fi) 1989-12-11
FI94534B (fi) 1995-06-15
IE891762L (en) 1989-12-10
IT1234508B (it) 1992-05-19
ES2012748A4 (es) 1990-04-16

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee