DE68921945T2 - Verfahren zur Lyophilisierung von Zellen Lyophilisierungsmedien und Verfahren zur Wiederherstellung von lyophilisierten Zellen. - Google Patents

Verfahren zur Lyophilisierung von Zellen Lyophilisierungsmedien und Verfahren zur Wiederherstellung von lyophilisierten Zellen.

Info

Publication number
DE68921945T2
DE68921945T2 DE68921945T DE68921945T DE68921945T2 DE 68921945 T2 DE68921945 T2 DE 68921945T2 DE 68921945 T DE68921945 T DE 68921945T DE 68921945 T DE68921945 T DE 68921945T DE 68921945 T2 DE68921945 T2 DE 68921945T2
Authority
DE
Germany
Prior art keywords
lyophilizing
cells
restoring
media
lyophilized
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE68921945T
Other languages
English (en)
Other versions
DE68921945D1 (de
Inventor
Raymond Paul Goodrich
Christine Marie Williams
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Terumo BCT Inc
Original Assignee
Cobe Laboratories Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cobe Laboratories Inc filed Critical Cobe Laboratories Inc
Application granted granted Critical
Publication of DE68921945D1 publication Critical patent/DE68921945D1/de
Publication of DE68921945T2 publication Critical patent/DE68921945T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N1/00—Preservation of bodies of humans or animals, or parts thereof
    • A01N1/02—Preservation of living parts
    • A01N1/0205—Chemical aspects
    • A01N1/021—Preservation or perfusion media, liquids, solids or gases used in the preservation of cells, tissue, organs or bodily fluids
    • A01N1/0221—Freeze-process protecting agents, i.e. substances protecting cells from effects of the physical process, e.g. cryoprotectants, osmolarity regulators like oncotic agents
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N1/00—Preservation of bodies of humans or animals, or parts thereof
    • A01N1/02—Preservation of living parts
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N1/00—Preservation of bodies of humans or animals, or parts thereof
    • A01N1/02—Preservation of living parts
    • A01N1/0205—Chemical aspects
DE68921945T 1988-08-26 1989-08-25 Verfahren zur Lyophilisierung von Zellen Lyophilisierungsmedien und Verfahren zur Wiederherstellung von lyophilisierten Zellen. Expired - Fee Related DE68921945T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US23758388A 1988-08-26 1988-08-26
US07/378,349 US5045446A (en) 1988-08-26 1989-07-11 Lyophilization of cells

Publications (2)

Publication Number Publication Date
DE68921945D1 DE68921945D1 (de) 1995-05-04
DE68921945T2 true DE68921945T2 (de) 1995-08-03

Family

ID=26930824

Family Applications (1)

Application Number Title Priority Date Filing Date
DE68921945T Expired - Fee Related DE68921945T2 (de) 1988-08-26 1989-08-25 Verfahren zur Lyophilisierung von Zellen Lyophilisierungsmedien und Verfahren zur Wiederherstellung von lyophilisierten Zellen.

Country Status (7)

Country Link
US (3) US5045446A (de)
EP (2) EP0508496A1 (de)
JP (1) JP2809735B2 (de)
AT (1) ATE120335T1 (de)
CA (1) CA1327763C (de)
DE (1) DE68921945T2 (de)
IL (1) IL91413A0 (de)

Families Citing this family (88)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL90188A0 (en) * 1988-05-18 1989-12-15 Cryopharm Corp Process and medium for the lyophilization of erythrocytes
US5153004A (en) * 1989-06-02 1992-10-06 Cryopharm Corporation Freezing and thawing of erythrocytes
US5045446A (en) * 1988-08-26 1991-09-03 Cryopharm Corporation Lyophilization of cells
US5958670A (en) * 1988-05-18 1999-09-28 Cobe Laboratories, Inc. Method of freezing cells and cell-like materials
US6007978A (en) * 1988-05-18 1999-12-28 Cobe Laboratories, Inc. Method of freezing cells and cell-like materials
US5178884A (en) * 1988-05-18 1993-01-12 Cryopharm Corporation Lyophilized and reconstituted red blood cell compositions
US5059518A (en) * 1988-10-20 1991-10-22 Coulter Corporation Stabilized lyophilized mammalian cells and method of making same
CA2062941A1 (en) * 1990-05-25 1991-11-26 Raymond P. Goodrich, Jr. Process for lyophilizing cells, cell-like materials and platelets in a mixture of biocompatable amphipathic polymers
US8067149B2 (en) * 1990-09-12 2011-11-29 Lifecell Corporation Acellular dermal matrix and method of use thereof for grafting
US5336616A (en) * 1990-09-12 1994-08-09 Lifecell Corporation Method for processing and preserving collagen-based tissues for transplantation
CA2051092C (en) * 1990-09-12 2002-07-23 Stephen A. Livesey Method and apparatus for cryopreparation, dry stabilization and rehydration of biological suspensions
EP0624190A4 (de) * 1992-01-21 1995-04-19 Cryopharm Corp Methode zum einfrieren von zellen und zellähnlichen materialien.
DE69332105T2 (de) * 1992-09-29 2003-03-06 Inhale Therapeutic Systems San Pulmonale abgabe von aktiven fragmenten des parathormons
US20030113273A1 (en) * 1996-06-17 2003-06-19 Patton John S. Methods and compositions for pulmonary delivery of insulin
US5580856A (en) * 1994-07-15 1996-12-03 Prestrelski; Steven J. Formulation of a reconstituted protein, and method and kit for the production thereof
US6586006B2 (en) 1994-08-04 2003-07-01 Elan Drug Delivery Limited Solid delivery systems for controlled release of molecules incorporated therein and methods of making same
US6290991B1 (en) * 1994-12-02 2001-09-18 Quandrant Holdings Cambridge Limited Solid dose delivery vehicle and methods of making same
AU3570495A (en) 1994-09-22 1996-04-09 Quadrant Holdings Cambridge Limited Compositions for use in rehydration and nutrition during athletic exercise and methods of making same
US6964771B1 (en) * 1995-06-07 2005-11-15 Elan Drug Delivery Limited Method for stably incorporating substances within dry, foamed glass matrices
US5965438A (en) * 1995-06-07 1999-10-12 Phyton, Inc. Cryopreservation of plant cells
US20050158699A1 (en) * 1995-06-07 2005-07-21 Kadkade Prakash G. Cryopreservation of plant cells
US5690963A (en) * 1995-06-30 1997-11-25 The United States Of America As Represented By The Secretary Of The Navy Freeze dried red blood cells
US5736313A (en) * 1995-10-20 1998-04-07 The United States Of America As Represented By The Secretary Of The Navy Method of lyophilizing platelets by incubation with high carbohydrate concentrations and supercooling prior to freezing
US6274369B1 (en) * 1996-02-02 2001-08-14 Invitrogen Corporation Method capable of increasing competency of bacterial cell transformation
US5762961A (en) * 1996-02-09 1998-06-09 Quadrant Holdings Cambridge Ltd. Rapidly soluble oral solid dosage forms, methods of making same, and compositions thereof
US5958455A (en) * 1996-02-09 1999-09-28 Quadrant Holdings Cambridge Ltd Oral solid dosage forms, methods of making same and compositions thereof
FR2746109B1 (fr) * 1996-03-12 1998-04-17 Rhone Poulenc Rorer Sa Milieu pour la conservation de materiel biologique
EP0921814A4 (de) * 1996-03-29 2001-10-04 Life Technologies Inc Verfahren zur Erhöhung der Lebensfähigkeit und der Transformationseffizienz von Bakterien während der Lagerung bei tiefen Temperaturen
US6632648B1 (en) * 1996-05-14 2003-10-14 Elan Drug Delivery Limited Methods of terminal sterilization of fibrinogen
US6509146B1 (en) 1996-05-29 2003-01-21 Universal Preservation Technologies, Inc. Scalable long-term shelf preservation of sensitive biological solutions and suspensions
US6040132A (en) * 1996-06-14 2000-03-21 Biostore New Zealand, Ltd. Methods for the lyophilization of living biological materials
US6060233A (en) * 1996-06-14 2000-05-09 Biostore New Zealand, Ltd Methods for the lyophilization of platelets, platelet membranes or erythrocytes
US5750330A (en) * 1996-06-19 1998-05-12 Litron Laboratories Method and composition for lyophilizing red blood cells
JP3989574B2 (ja) * 1996-07-11 2007-10-10 ネオ製薬工業株式会社 歯牙保存液
US6468782B1 (en) * 1996-12-05 2002-10-22 Quadrant Healthcare (Uk) Limited Methods of preserving prokaryotic cells and compositions obtained thereby
ATE230923T1 (de) * 1997-02-07 2003-02-15 Elan Drug Delivery Ltd Verfahren und zusammensetzungen zur herstellung getrockneter, lagerungsstabiler blutplättchen
EP1005529B1 (de) 1997-02-12 2005-04-27 Invitrogen Corporation Verfahren zur trocknung von kompetenten zellen
DE19707508C2 (de) * 1997-02-25 2000-05-31 Hemofarm Vrsac Verfahren zur Isolierung von Hämoglobin und die Verwendung des so isolierten Hämoglobins
US6071745A (en) 1997-06-27 2000-06-06 Bio-Rad Laboratories Method and formulation for lyophilizing cultured human cells to preserve RNA and DNA contained in cells for use in molecular biology experiments
US20060165606A1 (en) 1997-09-29 2006-07-27 Nektar Therapeutics Pulmonary delivery particles comprising water insoluble or crystalline active agents
US6565885B1 (en) 1997-09-29 2003-05-20 Inhale Therapeutic Systems, Inc. Methods of spray drying pharmaceutical compositions
US5955257A (en) * 1997-10-21 1999-09-21 Regents Of The University Of Minnesota Infusible grade short-term cell storage medium for mononuclear cells
GB2330516A (en) * 1997-10-22 1999-04-28 Elizabeth Acton Cryopreservation of cell suspensions
US5972592A (en) * 1997-12-29 1999-10-26 Cornell Research Foundation, Inc. Increasing reproductive efficiency of bull semen using fucose or a compound with a fucose moiety
ATE316757T1 (de) 1998-05-26 2006-02-15 Lifecell Corp Cryokonservierung menschlicher roter blutzellen
US6933326B1 (en) 1998-06-19 2005-08-23 Lifecell Coporation Particulate acellular tissue matrix
US6127177A (en) * 1998-09-11 2000-10-03 Massachusetts Institute Of Technology Controlled reversible poration for preservation of biological materials
US6508983B1 (en) 1999-07-19 2003-01-21 Cobe Cardiovascular Exchanger apparatus and method of manufacture
US7112576B1 (en) 1999-12-10 2006-09-26 Regents Of The University Of Minnesota Compositions and methods for cryopreservation of peripheral blood lymphocytes
US6790603B2 (en) * 1999-12-21 2004-09-14 Bioenergy, Inc. Compositions for the storage of platelets
AU2001234978A1 (en) * 2000-02-10 2001-08-20 The Regents Of The University Of California Therapeutic platelets and methods
US6770478B2 (en) 2000-02-10 2004-08-03 The Regents Of The University Of California Erythrocytic cells and method for preserving cells
US7871598B1 (en) 2000-05-10 2011-01-18 Novartis Ag Stable metal ion-lipid powdered pharmaceutical compositions for drug delivery and methods of use
AU6124601A (en) 2000-05-10 2001-11-20 Alliance Pharmaceutical Corporation Phospholipid-based powders for drug delivery
US8404217B2 (en) 2000-05-10 2013-03-26 Novartis Ag Formulation for pulmonary administration of antifungal agents, and associated methods of manufacture and use
US6653062B1 (en) * 2000-07-26 2003-11-25 Wisconsin Alumni Research Foundation Preservation and storage medium for biological materials
AU2002248178A1 (en) * 2000-12-15 2002-08-12 Stratagene Mutant cells with enhanced resistance to desiccation
US20030091971A1 (en) * 2001-09-14 2003-05-15 Invitrogen Corporation Composition for stabilizing biological materials
JP2005514393A (ja) 2001-12-19 2005-05-19 ネクター セラピューティクス アミノグリコシドの肺への供給
US20050031596A1 (en) * 2003-08-06 2005-02-10 Crowe John H. Cells and method for preserving cells
WO2004011616A2 (en) * 2002-07-26 2004-02-05 The General Hospital Corporation Systems and methods for cell preservation
US7270946B2 (en) * 2002-10-04 2007-09-18 Organ Recovery Systems, Inc. Method for treatment of cellular materials with sugars prior to preservation
GB0230152D0 (en) * 2002-12-24 2003-02-05 Sinvent As Product
US20050095320A1 (en) * 2003-10-29 2005-05-05 Richard Botteri [An Isotonic Sports Drink for Female Athletes Fortified with Iron, Calcium and Essential Vitamins for Use in Rehydration and Nutrition During Execise and Competition]
US20050100636A1 (en) * 2003-11-10 2005-05-12 Megan Botteri [A Low-Calorie Sports Drink For Physically Active Women That is Fortified with Iron, Calcium and Essential Vitamins for Use in Rehydration and Replacing Electrolytes Lost During Periods of Physical Activity]
ES2668551T3 (es) 2005-09-26 2018-05-18 Lifecell Corporation Composición seca de plaquetas
KR20080103637A (ko) * 2007-05-25 2008-11-28 주식회사 알앤엘바이오 지방유래 줄기세포를 함유하는 사지말단부 허혈성 질환의세포치료용 조성물
BRPI1008009B1 (pt) * 2009-02-23 2018-05-29 Cell & Tissue Systems, Inc. Métodos para criopreservação de tecido sem gelo
US20180042850A1 (en) * 2010-02-19 2018-02-15 Cadila Pharmaceuticals Ltd. Pharmaceutical Composition of Killed Cells with Substantially Retained Immunogenicity
WO2011101796A1 (en) 2010-02-19 2011-08-25 Cadila Pharmaceuticals Limited A pharmaceutical composition of killed cells with substantially retained immunogenicity
WO2011149529A2 (en) * 2010-05-25 2011-12-01 The Research Foundation Of State University Of New York Cell-based preparations for wound management
US20130008191A1 (en) * 2011-07-07 2013-01-10 Suchak Naresh J Methods for freezing and thawing proteins
US8906668B2 (en) 2012-11-23 2014-12-09 Seres Health, Inc. Synergistic bacterial compositions and methods of production and use thereof
EP3584308A3 (de) 2013-02-04 2020-03-04 Seres Therapeutics, Inc. Zusammensetzungen und verfahren
EP3904502A3 (de) 2013-02-04 2022-02-23 Seres Therapeutics, Inc. Zusammensetzungen und verfahren
CA2906921A1 (en) 2013-03-15 2014-09-18 Seres Therapeutics, Inc. Network-based microbial compositions and methods
MX367109B (es) 2013-11-25 2019-08-05 Seres Therapeutics Inc Composiciones bacterianas sinergicas y sus metodos de produccion y usos.
EP3082431A4 (de) 2013-12-16 2017-11-15 Seres Therapeutics, Inc. Bakterielle zusammensetzungen und verfahren zur verwendung davon zur behandlung von immunsystemkrankheiten
WO2015191599A2 (en) 2014-06-09 2015-12-17 Terumo Bct, Inc. Lyophilization
WO2016086071A1 (en) * 2014-11-24 2016-06-02 Nueou, Inc. Spectrally encoded consumable spectrometer apparatus and methods
WO2017100915A1 (en) * 2015-12-14 2017-06-22 Groupe Santé Devonian Inc. Extraction and process for active thylakoid membranes
JP6957615B2 (ja) 2016-07-22 2021-11-02 ティシュー テスティング テクノロジーズ エルエルシーＴｉｓｓｕｅ Ｔｅｓｔｉｎｇ Ｔｅｃｈｎｏｌｏｇｉｅｓ Ｌｌｃ 糖脂質による細胞凍結保存性の向上
US11246308B2 (en) 2016-12-20 2022-02-15 Tissue Testing Technologies Llc Ice-free preservation of large volume tissue samples for viable, functional tissue banking
JP2020530840A (ja) 2017-08-14 2020-10-29 セレス セラピューティクス インコーポレイテッド 胆汁うっ滞性疾患を治療するための組成物及び方法
EP3694322A1 (de) 2017-10-09 2020-08-19 Terumo BCT Biotechnologies, LLC Lyophilisierungsbehälter und verfahren zu seiner verwendung
CA3224729A1 (en) 2019-03-14 2020-09-17 Terumo Bct Biotechnologies, Llc Lyophilization loading tray assembly and system
WO2021091984A1 (en) 2019-11-07 2021-05-14 Tissue Testing Technologies Llc Ice-free vitrification and nano-warming of large tissue samples
US20220354108A1 (en) 2021-05-04 2022-11-10 Tissue Testing Technologies Llc Preservation methods using trehalose with other cryoprotectants being absent from the cryopreservation protocol

Family Cites Families (91)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR654692A (fr) * 1928-01-04 1929-04-09 Assemblage pour poutres et colonnes ou piliers métalliques
US2786014A (en) * 1952-09-10 1957-03-19 James L Tullis Platelet preservation
US2875588A (en) * 1953-06-11 1959-03-03 Ohio Commw Eng Co Preservation of red blood cells
US3079919A (en) * 1958-11-10 1963-03-05 Baxter Laboratories Inc Parenteral solution equipment and method
US3228838A (en) * 1959-04-23 1966-01-11 Union Carbide Corp Preservation of biological substances
US3080725A (en) * 1960-08-11 1963-03-12 Union Carbide Corp Method and apparatus for controlled rate cooling and warming of biological substances
US3158283A (en) * 1961-04-24 1964-11-24 Union Carbide Corp Corrugated contained for the low temperature preservation of biological substances
US3344167A (en) * 1962-03-19 1967-09-26 Exxon Research Engineering Co Difluoraminoalkyl nitrates
US3303662A (en) * 1963-03-01 1967-02-14 Union Carbide Corp Process for cell preservation
BE643051A (de) * 1963-05-31 1964-05-15
US3347745A (en) * 1963-12-06 1967-10-17 Union Carbide Corp Process for freezing erythrocytes
FR1413976A (fr) * 1964-08-31 1965-10-15 Récipient souple en matière plastique, notamment pour sérum
US3344617A (en) * 1965-02-25 1967-10-03 Union Carbide Corp Apparatus for the preservation of biological substances
NL6509726A (de) * 1965-07-28 1967-01-30
NL126572C (de) * 1966-03-24
DE2025718C3 (de) * 1967-11-13 1979-06-13 Abbott Laboratories, Chicago, Ill. (V.St.A.) Verfahren zum Stabilisieren von lyophillsierten Erythrozyten
GB1244344A (en) * 1967-11-13 1971-08-25 Abbott Lab Hemagglutination testing procedure employing stabilized and potentiated erythrocytes and a method for their preparation
US3758382A (en) * 1968-07-26 1973-09-11 Us Navy Ve agent process of freezing blood using a hydroxyalkyl starch as cryoprotecti
US3554256A (en) * 1968-11-08 1971-01-12 Dave Champman Goldsmith & Yama Flexible intravenous container
US3677022A (en) * 1969-07-24 1972-07-18 Redeco Method for extending the useful storage period of biological substances such as blood
CA928215A (en) * 1969-08-08 1973-06-12 M. Brake Jon Process for the cryogenic preservation of blood and erythrocytes and products produced thereby
US3915794A (en) * 1973-02-09 1975-10-28 Rit Rech Ind Therapeut Stabilizing compositions for cell-free viruses and cell-free virus preparations containing them
DE2310964A1 (de) * 1973-03-02 1974-09-05 Schering Ag Antigen- bzw. antigen-proteinkonjugatbeschichtete erythrocytenpraeparation
FR2284842A1 (fr) * 1974-09-11 1976-04-09 Nestle Sa Perfectionnement apporte la lyophilisation des produits solides, liquides ou pateux
DE2532183C3 (de) * 1975-07-18 1982-03-04 Behringwerke Ag, 3550 Marburg Polyionische isotonische Salzlösung zur Konservierung von Erythrozyten oder zur Perfusion und zur Konservierung von zur Transplantion bestimmter Organen
CA1055932A (en) * 1975-10-22 1979-06-05 Hematech Inc. Blood substitute based on hemoglobin
US4018911A (en) * 1975-11-10 1977-04-19 The United States Of America As Represented By The Secretary Of The Navy Method for large volume freezing and thawing of packed erythrocytes
DE2551208C3 (de) * 1975-11-14 1981-05-27 Behringwerke Ag, 3550 Marburg Verfahren zur Herstellung einer stabilen Erythrozyten-Präparation
US4059967A (en) * 1976-02-19 1977-11-29 The Community Blood Council Of Greater New York, Inc. Process for freezing blood platelets
US4132594A (en) * 1976-06-28 1979-01-02 The United States Of America As Represented By The Administrator Of The National Aeronautics And Space Administration Gas diffusion liquid storage bag and method of use for storing blood
US4131200A (en) * 1976-07-06 1978-12-26 Union Carbide Corporation Thermoplastic blood bag
SU686732A1 (ru) * 1977-05-05 1979-09-25 Владивостокский государственный медицинский институт Способ получени комплемента
US4112070A (en) * 1977-06-08 1978-09-05 Research Corporation Blood preservation system
US4320111A (en) * 1977-06-14 1982-03-16 American Home Products Corporation Immunologic compositions methods of preparation and use
DE2820603A1 (de) * 1978-05-11 1979-11-15 Gersonde Klaus Prof Dr Modifizierte intakte erythrozyten und sie enthaltendes blut bzw. blutkonserven
US4278198A (en) * 1977-11-17 1981-07-14 Baxter Travenol Laboratories, Inc. Flexible collapsible container with a stiffening member
US4243687A (en) * 1979-01-10 1981-01-06 Leo Kline Freeze-dried natural sour dough starter
BR8007230A (pt) * 1979-03-02 1981-01-21 Unilever Nv Comestiveis doces gelados compositos e processos para sua preparacao
DE2929278A1 (de) * 1979-07-19 1981-01-29 Forschungsgesellschaft Fuer Bi Verfahren zum eingefrieren von zellsuspensionen
US4267269A (en) * 1980-02-05 1981-05-12 Baxter Travenol Laboratories, Inc. Red cell storage solution
DE3007913A1 (de) * 1980-03-01 1981-09-17 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V., 8000 München Verfahren zum einfrieren von biologischem zellmaterial unter benutzung von frierschutzmitteln, die vor dem einsatz des zellmaterials nicht ausgewaschen werden muessen
SU959786A1 (ru) * 1980-04-17 1982-09-23 Московский технологический институт мясной и молочной промышленности Способ консервировани цельной крови
JPS577419A (en) * 1980-06-17 1982-01-14 Toshiba Kagaku Kogyo Kk Erythrocyte storing solution
SU932438A1 (ru) * 1980-07-31 1982-05-30 Московский Ордена Трудового Красного Знамени Физико-Технический Институт Перестраиваемый отрезающий оптический фильтр
US4521975A (en) * 1981-05-04 1985-06-11 Marquest Medical Products, Inc. Lyophilizing and forming biologicals having a predetermined unit dosage
JPS589688A (ja) * 1981-07-06 1983-01-20 Toyobo Co Ltd 安定な酵素組成物
JPS58131566A (ja) * 1982-04-28 1983-08-05 Green Cross Corp:The 赤血球凍結乾燥物
DE3225408A1 (de) * 1982-07-07 1984-01-12 Biotest-Serum-Institut Gmbh, 6000 Frankfurt Waessrige loesung zum suspendieren und lagern von zellen, insbesondere erythrozyten
FR2542617B2 (fr) * 1982-07-09 1986-06-06 Rgl Transfusion Sanguine Centr Solution protectrice pour la conservation de cellules fonctionnelles
US4639513A (en) * 1984-02-02 1987-01-27 Cuno Inc. Intravenously injectable immunoglobulin G (IGG) and method for producing same
US4883459A (en) * 1983-07-29 1989-11-28 Reynaldo Calderon Retrograde perfusion
US4865871A (en) * 1983-08-23 1989-09-12 Board Of Regents The University Of Texas System Method for cryopreparing biological tissue
JPS6058827A (ja) * 1983-09-10 1985-04-05 Ricoh Co Ltd ダハミラ−アレイ成形金型
US4585735A (en) * 1984-07-19 1986-04-29 American National Red Cross Prolonged storage of red blood cells
US5084377A (en) * 1984-09-19 1992-01-28 Larry Rowan Cryogenic suspension method
FR2581289A1 (fr) * 1985-05-06 1986-11-07 Rgl Transfusion Sanguine Centr Solution synthetique pour la conservation prolongee de concentres erythrocytaires
GB8604983D0 (en) * 1986-02-28 1986-04-09 Biocompatibles Ltd Protein preservation
JPH0827283B2 (ja) * 1986-03-10 1996-03-21 財団法人化学及血清療法研究所 免疫凝集反応用組成物
US4806343A (en) * 1986-03-13 1989-02-21 University Of Southwestern Louisiana Cryogenic protectant for proteins
US4731330A (en) * 1986-07-01 1988-03-15 Biotrack, Inc. Whole blood control sample
JPS63106562A (ja) * 1986-10-23 1988-05-11 Green Cross Corp:The 逆受身赤血球凝集反応用試薬
US4764463A (en) * 1986-10-30 1988-08-16 The University Of Tennessee Research Corporation Platelet cyropreservation
US4963362A (en) * 1987-08-07 1990-10-16 Regents Of The University Of Minnesota Freeze-dried liposome mixture containing cyclosporin
US4980277A (en) * 1987-10-16 1990-12-25 Cultor Ltd. Cryoprotectant solution and method
US5192553A (en) * 1987-11-12 1993-03-09 Biocyte Corporation Isolation and preservation of fetal and neonatal hematopoietic stem and progenitor cells of the blood and methods of therapeutic use
JPH0769585B2 (ja) * 1987-12-14 1995-07-31 富士写真フイルム株式会社 写真用ハロゲン化銀乳剤の製造方法
US5153004A (en) * 1989-06-02 1992-10-06 Cryopharm Corporation Freezing and thawing of erythrocytes
US5178884A (en) * 1988-05-18 1993-01-12 Cryopharm Corporation Lyophilized and reconstituted red blood cell compositions
US5171661A (en) * 1988-05-18 1992-12-15 Cryopharm Corporation Medium for lyophilization of erythrocytes
IL90188A0 (en) * 1988-05-18 1989-12-15 Cryopharm Corp Process and medium for the lyophilization of erythrocytes
US5213814A (en) * 1989-04-10 1993-05-25 Cryopharm Corporation Lyophilized and reconstituted blood platelet compositions
US5045446A (en) * 1988-08-26 1991-09-03 Cryopharm Corporation Lyophilization of cells
US5043261A (en) * 1989-04-10 1991-08-27 Cryopharm Corporation Lyophilized and reconstituted red blood cell and hemosome compositions
US4900780A (en) * 1988-05-25 1990-02-13 Masonic Medical Research Laboratory Acellular resuscitative fluid
FI80172C (fi) * 1988-05-25 1990-04-10 Nokia Mobile Phones Ltd Fm-mellanfrekvenskrets.
DE3817906A1 (de) * 1988-05-26 1989-11-30 Boehringer Mannheim Gmbh Verfahren und behaeltnis zum gefriertrocknen unter sterilen bedingungen
EP0356258A3 (de) * 1988-08-26 1990-06-06 Cryopharm Corporation Gefriertrocknungsmethode für rote Blutkörperchen und Mittel dafür
US4874690A (en) * 1988-08-26 1989-10-17 Cryopharm Corporation Lyophilization of red blood cells
US5059518A (en) * 1988-10-20 1991-10-22 Coulter Corporation Stabilized lyophilized mammalian cells and method of making same
US5030560A (en) * 1988-11-04 1991-07-09 Immucor, Inc. Method for drying mammalian cells for use in solid phase immunoassays and articles incorporating same
US4983515A (en) * 1989-02-16 1991-01-08 E. I. Du Pont De Nemours And Company Labeled cryopreserved cells for use as targets in cytotoxicity assays
GB8903593D0 (en) * 1989-02-16 1989-04-05 Pafra Ltd Storage of materials
US5118792A (en) * 1989-05-10 1992-06-02 Dna Plant Technology Corporation Ice crystal growth suppression polypeptides and method of making
GB8920007D0 (en) * 1989-09-05 1989-10-18 Devilbiss Co Spraygun
US4973327A (en) * 1989-11-01 1990-11-27 Cryopharm Blood bag for lyophilization
DE69133198T2 (de) * 1990-04-16 2003-07-24 Baxter Int Methode zur unschädlichmachung viraler und bakterieller blutverunreinigungen
CA2062941A1 (en) * 1990-05-25 1991-11-26 Raymond P. Goodrich, Jr. Process for lyophilizing cells, cell-like materials and platelets in a mixture of biocompatable amphipathic polymers
US5145770A (en) * 1990-06-04 1992-09-08 Biosurface Technology, Inc. Cryopreservation of cultured epithelial sheets
CA2051092C (en) * 1990-09-12 2002-07-23 Stephen A. Livesey Method and apparatus for cryopreparation, dry stabilization and rehydration of biological suspensions
WO1992014360A1 (en) * 1991-02-15 1992-09-03 Cryopharm Corporation Method of lyophilization and reconstitution of mixtures of nucleated non-mammalian cells and blood matter
US5242792A (en) * 1991-02-25 1993-09-07 The United States Of America As Represented By The Secretary Of The Navy Method for the preservation of red blood cells by lyophilization using glycerol or inositol with disaccharides

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US5425951A (en) 1995-06-20
DE68921945D1 (de) 1995-05-04
JP2809735B2 (ja) 1998-10-15
EP0356257A3 (en) 1990-07-25
US5045446A (en) 1991-09-03
CA1327763C (en) 1994-03-15
US5648206A (en) 1997-07-15
ATE120335T1 (de) 1995-04-15
EP0356257A2 (de) 1990-02-28
JPH02186981A (ja) 1990-07-23
IL91413A0 (en) 1990-04-29
EP0508496A1 (de) 1992-10-14
EP0356257B1 (de) 1995-03-29

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