DE68926255T2 - Fühleroberflächen, fähig zur selektiven biomolekularen interaktionen zur verwendung in biosensorsystemen - Google Patents

Fühleroberflächen, fähig zur selektiven biomolekularen interaktionen zur verwendung in biosensorsystemen

Info

Publication number
DE68926255T2
DE68926255T2 DE68926255T DE68926255T DE68926255T2 DE 68926255 T2 DE68926255 T2 DE 68926255T2 DE 68926255 T DE68926255 T DE 68926255T DE 68926255 T DE68926255 T DE 68926255T DE 68926255 T2 DE68926255 T2 DE 68926255T2
Authority
DE
Germany
Prior art keywords
sensor surfaces
biomolecular interactions
biosensor systems
matrix coating
selective biomolecular
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE68926255T
Other languages
English (en)
Other versions
DE68926255D1 (de
Inventor
Jan Bergstroem
Stefan Loefas
Bo Johnsson
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Cytiva Sweden AB
Original Assignee
Pharmacia Biosensor AB
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=20373907&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE68926255(T2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Pharmacia Biosensor AB filed Critical Pharmacia Biosensor AB
Publication of DE68926255D1 publication Critical patent/DE68926255D1/de
Application granted granted Critical
Publication of DE68926255T2 publication Critical patent/DE68926255T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/001—Enzyme electrodes
    • C12Q1/002—Electrode membranes
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54353—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals with ligand attached to the carrier via a chemical coupling agent
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54393—Improving reaction conditions or stability, e.g. by coating or irradiation of surface, by reduction of non-specific binding, by promotion of specific binding
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/551—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being inorganic
    • G01N33/553—Metal or metal coated
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y15/00—Nanotechnology for interacting, sensing or actuating, e.g. quantum dots as markers in protein assays or molecular motors
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y30/00—Nanotechnology for materials or surface science, e.g. nanocomposites
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/808—Optical sensing apparatus
DE68926255T 1988-11-10 1989-11-09 Fühleroberflächen, fähig zur selektiven biomolekularen interaktionen zur verwendung in biosensorsystemen Expired - Lifetime DE68926255T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
SE8804073A SE462454B (sv) 1988-11-10 1988-11-10 Maetyta foer anvaendning i biosensorer
PCT/SE1989/000642 WO1990005303A1 (en) 1988-11-10 1989-11-09 Sensing surfaces capable of selective biomolecular interactions, to be used in biosensor systems

Publications (2)

Publication Number Publication Date
DE68926255D1 DE68926255D1 (de) 1996-05-15
DE68926255T2 true DE68926255T2 (de) 1996-10-31

Family

ID=20373907

Family Applications (1)

Application Number Title Priority Date Filing Date
DE68926255T Expired - Lifetime DE68926255T2 (de) 1988-11-10 1989-11-09 Fühleroberflächen, fähig zur selektiven biomolekularen interaktionen zur verwendung in biosensorsystemen

Country Status (7)

Country Link
US (2) US5242828A (de)
EP (1) EP0589867B1 (de)
JP (1) JP2815120B2 (de)
AT (1) ATE136651T1 (de)
DE (1) DE68926255T2 (de)
SE (1) SE462454B (de)
WO (1) WO1990005303A1 (de)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10126341A1 (de) * 2001-05-30 2002-12-12 Siemens Ag Elektrochemischer DNA-Sensor, Verfahren zur Herstellung und Betrieb eines solchen DNA-Sensors
DE10319572A1 (de) * 2003-04-30 2004-11-25 Kist-Europe Forschungsgesellschaft Mbh Verfahren zur Bestimmung der Konzentration eines Analyten

Families Citing this family (494)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE462454B (sv) * 1988-11-10 1990-06-25 Pharmacia Ab Maetyta foer anvaendning i biosensorer
WO1992003732A2 (en) * 1990-08-28 1992-03-05 Bioprobe International, Inc. Compositions and methods for enhanced binding in biological assays
SE501013C2 (sv) 1990-10-01 1994-10-17 Pharmacia Biosensor Ab Förfarande för förbättring av analys med bindning till fast fas
DE59106527D1 (de) * 1990-11-14 1995-10-26 Hoffmann La Roche Immunsensorischer Wandler und Verfahren zu seiner Herstellung.
US5763191A (en) * 1990-12-12 1998-06-09 Boehringer Mannheim Gmbh Universal binding film
JPH06507709A (ja) * 1991-06-04 1994-09-01 ファイスンズ　ピーエルシー 分析装置
USRE40835E1 (en) * 1992-01-16 2009-07-07 BioGenx Laboratories, Inc. Enhancement of immunochemical staining in aldehyde-fixed tissue
DE4216980C2 (de) * 1992-05-19 1994-04-21 Eppendorf Geraetebau Netheler Immunosensorisches Nachweisverfahren
WO1993025910A1 (en) * 1992-06-05 1993-12-23 Pharmacia Biosensor Ab Assay for multiple analytes with co-immobilized ligands
DK100592D0 (da) * 1992-08-10 1992-08-10 Mouritsen & Elsner Aps Metode til kemisk kobling paa faste faser
US5656504A (en) * 1992-10-26 1997-08-12 Pharmacia Biosensor Ab Method of preventing undesired binding in solid phase assays
AU6393994A (en) * 1993-02-19 1994-09-14 Arris Pharmaceutical Corporation Thin film hpmp matrix systems and methods for constructing and displaying ligands
US5512492A (en) * 1993-05-18 1996-04-30 University Of Utah Research Foundation Waveguide immunosensor with coating chemistry providing enhanced sensitivity
US5919712A (en) 1993-05-18 1999-07-06 University Of Utah Research Foundation Apparatus and methods for multi-analyte homogeneous fluoro-immunoassays
US5395587A (en) * 1993-07-06 1995-03-07 Smithkline Beecham Corporation Surface plasmon resonance detector having collector for eluted ligate
US6071699A (en) 1996-06-07 2000-06-06 California Institute Of Technology Nucleic acid mediated electron transfer
US5824473A (en) 1993-12-10 1998-10-20 California Institute Of Technology Nucleic acid mediated electron transfer
US20010055581A1 (en) 1994-03-18 2001-12-27 Lawrence Tamarkin Composition and method for delivery of biologically-active factors
BE1008221A3 (fr) * 1994-03-28 1996-02-20 Anda Biolog Sa Support solide fixant au moins un composant a activite biologique comprenant un site reactionnel, stabilise et procede pour son obtention.
GB9419001D0 (en) * 1994-09-21 1994-11-09 Applied Research Systems Assay method
DE4433980C2 (de) * 1994-09-23 1996-08-22 Boehringer Ingelheim Int Verfahren und Biosensorhit zur Untersuchung der Wechselwirkung von Biomolekülen mittels Oberflächen-Plasma-Resonanz
US6472148B1 (en) 1994-09-26 2002-10-29 President And Fellows Of Harvard College Molecular recognition at surfaces derivatized with self-assembled monolayers
US5620850A (en) 1994-09-26 1997-04-15 President And Fellows Of Harvard College Molecular recognition at surfaces derivatized with self-assembled monolayers
SE9403245D0 (sv) * 1994-09-26 1994-09-26 Pharmacia Biosensor Ab Improvements relating to bilayer lipid membranes
JP3362192B2 (ja) * 1994-12-06 2003-01-07 味の素株式会社 検査方法及び検査薬
US5567301A (en) * 1995-03-01 1996-10-22 Illinois Institute Of Technology Antibody covalently bound film immunobiosensor
US5629213A (en) * 1995-03-03 1997-05-13 Kornguth; Steven E. Analytical biosensor
IL114692A (en) * 1995-07-21 1999-10-28 Yissum Res Dev Co Determination of an analyte in a liquid medium
GB9518429D0 (en) * 1995-09-08 1995-11-08 Pharmacia Biosensor A rapid method for providing kinetic and structural data in molecular interaction analysis
US6165335A (en) 1996-04-25 2000-12-26 Pence And Mcgill University Biosensor device and method
US6130037A (en) * 1996-04-25 2000-10-10 Pence And Mcgill University Biosensor device and method
DE69719817T2 (de) * 1996-04-25 2003-12-24 Pence Inc Biosensor-vorrichtung und verfahren
US6107080A (en) * 1996-04-25 2000-08-22 Mcgill University Biosensor device and method
US5955379A (en) * 1996-04-25 1999-09-21 Mcgill University Biosensor device and method
US5852229A (en) * 1996-05-29 1998-12-22 Kimberly-Clark Worldwide, Inc. Piezoelectric resonator chemical sensing device
DE19622628A1 (de) * 1996-06-05 1997-12-11 Boehringer Mannheim Gmbh Stabilisierung von Metallkonjugaten
SE9602545L (sv) * 1996-06-25 1997-12-26 Michael Mecklenburg Metod för att diskriminera komplexa biologiska prover
US5780251A (en) * 1996-06-27 1998-07-14 Fci Fiberchem, Inc. Ultrasensitive single-step, solid-state competitive immunoassay sensor with interference modifier and/or gel layer
US6020047A (en) * 1996-09-04 2000-02-01 Kimberly-Clark Worldwide, Inc. Polymer films having a printed self-assembling monolayer
US7393645B2 (en) 1996-11-05 2008-07-01 Clinical Micro Sensors, Inc. Compositions for the electronic detection of analytes utilizing monolayers
US7014992B1 (en) * 1996-11-05 2006-03-21 Clinical Micro Sensors, Inc. Conductive oligomers attached to electrodes and nucleoside analogs
US7381525B1 (en) 1997-03-07 2008-06-03 Clinical Micro Sensors, Inc. AC/DC voltage apparatus for detection of nucleic acids
US7160678B1 (en) 1996-11-05 2007-01-09 Clinical Micro Sensors, Inc. Compositions for the electronic detection of analytes utilizing monolayers
US6096273A (en) * 1996-11-05 2000-08-01 Clinical Micro Sensors Electrodes linked via conductive oligomers to nucleic acids
US7045285B1 (en) * 1996-11-05 2006-05-16 Clinical Micro Sensors, Inc. Electronic transfer moieties attached to peptide nucleic acids
GB9623820D0 (en) * 1996-11-16 1997-01-08 Secr Defence Surface plasma resonance sensor
US5846843A (en) * 1996-11-18 1998-12-08 The University Of Toledo Sensor using long range surface plasmon resonance with diffraction double-grating
SE9604575D0 (sv) * 1996-12-12 1996-12-12 Biacore Ab Method and system for analyte determination
US6048623A (en) * 1996-12-18 2000-04-11 Kimberly-Clark Worldwide, Inc. Method of contact printing on gold coated films
US5922550A (en) * 1996-12-18 1999-07-13 Kimberly-Clark Worldwide, Inc. Biosensing devices which produce diffraction images
US6306584B1 (en) 1997-01-21 2001-10-23 President And Fellows Of Harvard College Electronic-property probing of biological molecules at surfaces
US5958704A (en) * 1997-03-12 1999-09-28 Ddx, Inc. Sensing system for specific substance and molecule detection
US6180288B1 (en) * 1997-03-21 2001-01-30 Kimberly-Clark Worldwide, Inc. Gel sensors and method of use thereof
WO1998048281A1 (en) * 1997-04-24 1998-10-29 American Home Products Corporation Method for the identification and characterization of nuclear receptor ligands
US7560237B2 (en) * 1997-06-12 2009-07-14 Osmetech Technology Inc. Electronics method for the detection of analytes
US6013459A (en) 1997-06-12 2000-01-11 Clinical Micro Sensors, Inc. Detection of analytes using reorganization energy
KR100664331B1 (ko) 1997-07-28 2007-01-02 메디칼 바이오시스템스 리미티드 핵산 서열 분석
US6407218B1 (en) 1997-11-10 2002-06-18 Cytimmune Sciences, Inc. Method and compositions for enhancing immune response and for the production of in vitro mabs
US7229841B2 (en) 2001-04-30 2007-06-12 Cytimmune Sciences, Inc. Colloidal metal compositions and methods
DE19751658A1 (de) * 1997-11-21 1999-07-29 Wolfbeis Otto S Prof Dr Verfahren zur Bildung lateral organisierter Strukturen auf Trägeroberflächen
US6036924A (en) 1997-12-04 2000-03-14 Hewlett-Packard Company Cassette of lancet cartridges for sampling blood
US6060256A (en) * 1997-12-16 2000-05-09 Kimberly-Clark Worldwide, Inc. Optical diffraction biosensor
DE19757302A1 (de) * 1997-12-22 1999-07-01 Siemens Ag Beschichtung von Metalloberflächen insbesondere für die Mikroelektronik
US6087102A (en) * 1998-01-07 2000-07-11 Clontech Laboratories, Inc. Polymeric arrays and methods for their use in binding assays
AU2337899A (en) 1998-01-22 1999-08-09 Purdue Research Foundation Functionalized porous silicon surfaces
CA2319170A1 (en) 1998-01-27 1999-07-29 Clinical Micro Sensors, Inc. Amplification of nucleic acids with electronic detection
AU2583899A (en) 1998-02-04 1999-08-23 Invitrogen Corporation Microarrays and uses therefor
US6391005B1 (en) 1998-03-30 2002-05-21 Agilent Technologies, Inc. Apparatus and method for penetration with shaft having a sensor for sensing penetration depth
DE19817180C2 (de) * 1998-04-17 2000-04-27 Biotul Bio Instr Gmbh Biosensor mit modifizierter Edelmetalloberfläche und Verfahren zu seiner Herstellung
US6472224B1 (en) 1998-04-17 2002-10-29 Franz Schleicher Biosensor with modified precious metal surface and process for the preparation thereof
DE19818360C2 (de) * 1998-04-24 2000-05-31 Suisse Electronique Microtech Dextranbeschichtete Oberfläche
DE69939464D1 (de) 1998-05-06 2008-10-16 Clinical Micro Sensors Inc Elekronische verfahren zur erkennung von analyten mit hilfe von einfachschichten
US6692696B1 (en) * 1998-06-18 2004-02-17 ARETé ASSOCIATES Biosensor
US6761816B1 (en) 1998-06-23 2004-07-13 Clinical Micro Systems, Inc. Printed circuit boards with monolayers and capture ligands
US7087148B1 (en) 1998-06-23 2006-08-08 Clinical Micro Sensors, Inc. Binding acceleration techniques for the detection of analytes
US20050244954A1 (en) * 1998-06-23 2005-11-03 Blackburn Gary F Binding acceleration techniques for the detection of analytes
US20020119579A1 (en) * 1998-07-14 2002-08-29 Peter Wagner Arrays devices and methods of use thereof
US6406921B1 (en) 1998-07-14 2002-06-18 Zyomyx, Incorporated Protein arrays for high-throughput screening
US6897073B2 (en) 1998-07-14 2005-05-24 Zyomyx, Inc. Non-specific binding resistant protein arrays and methods for making the same
US6576478B1 (en) 1998-07-14 2003-06-10 Zyomyx, Inc. Microdevices for high-throughput screening of biomolecules
US6682942B1 (en) 1998-07-14 2004-01-27 Zyomyx, Inc. Microdevices for screening biomolecules
US6573107B1 (en) * 1998-08-05 2003-06-03 The University Of Wyoming Immunochemical detection of an explosive substance in the gas phase through surface plasmon resonance spectroscopy
US6740518B1 (en) * 1998-09-17 2004-05-25 Clinical Micro Sensors, Inc. Signal detection techniques for the detection of analytes
WO2000024941A1 (en) * 1998-10-27 2000-05-04 Clinical Micro Sensors, Inc. Detection of target analytes using particles and electrodes
JP3657790B2 (ja) * 1998-11-09 2005-06-08 独立行政法人科学技術振興機構 Ｓｐｒセンサー用金属薄膜、その製法およびそれを用いた測定方法
US6221579B1 (en) 1998-12-11 2001-04-24 Kimberly-Clark Worldwide, Inc. Patterned binding of functionalized microspheres for optical diffraction-based biosensors
US6579673B2 (en) 1998-12-17 2003-06-17 Kimberly-Clark Worldwide, Inc. Patterned deposition of antibody binding protein for optical diffraction-based biosensors
US6833267B1 (en) 1998-12-30 2004-12-21 Clinical Micro Sensors, Inc. Tissue collection devices containing biosensors
CN1309771A (zh) * 1999-01-12 2001-08-22 株式会社荏原制作所 抗原的检测方法以及生物传感器
CA2360027A1 (en) 1999-01-25 2000-07-27 Biochip Technologies Gmbh Immobilization of molecules on surfaces via polymer brushes
EP1035218A1 (de) * 1999-03-03 2000-09-13 BioChip Technologies GmbH Immobilisierung von Molekülen an Oberflächen über verzweigte Polymerketten
AUPP856399A0 (en) * 1999-02-08 1999-03-04 Australian Membrane And Biotechnology Research Institute Improved compounds for protein binding
DE19908525C2 (de) * 1999-02-26 2001-05-31 Inst Chemo Biosensorik Wasserlösliches Copolymer und Verwendung hiervon
WO2000052456A1 (en) 1999-03-02 2000-09-08 Helix Biopharma Corporation Biosensor device and method
EP1961826A3 (de) 1999-03-10 2008-09-17 ASM Scientific, Inc. Verfahren zur direkten Sequenzierung von Nukleinsäuren
GB9907813D0 (en) * 1999-04-06 1999-06-02 Medical Biosystems Ltd Synthesis
DE19916638C2 (de) * 1999-04-13 2002-11-07 Jandratek Gmbh Oberflächen zur Verbesserung des Bindungsverhaltens von Analytmolekülen auf der Basis kovalent gebundener hydrophiler Spacer an Hydrogelen
US20040053290A1 (en) * 2000-01-11 2004-03-18 Terbrueggen Robert Henry Devices and methods for biochip multiplexing
US20020177135A1 (en) 1999-07-27 2002-11-28 Doung Hau H. Devices and methods for biochip multiplexing
US7312087B2 (en) 2000-01-11 2007-12-25 Clinical Micro Sensors, Inc. Devices and methods for biochip multiplexing
US6942771B1 (en) * 1999-04-21 2005-09-13 Clinical Micro Sensors, Inc. Microfluidic systems in the electrochemical detection of target analytes
GB9909245D0 (en) * 1999-04-22 1999-06-16 Univ Cranfield Reactive polymers and their application in reactions and assays
CA2368247A1 (en) * 1999-04-27 2000-11-09 Ciphergen Biosystems, Inc. Probes for a gas phase ion spectrometer
US6127129A (en) * 1999-05-04 2000-10-03 Wisconsin Alumni Research Foundation Process to create biomolecule and/or cellular arrays on metal surfaces and product produced thereby
US6489102B2 (en) 1999-08-05 2002-12-03 Wisconsin Alumni Research Foundation Biomolecule and/or cellular arrays on metal surfaces and product produced thereby
AU775060B2 (en) 1999-06-18 2004-07-15 Ge Healthcare Bio-Sciences Ab Method and apparatus for assaying a drug candidate to estimate a pharmacokineticparameter associated therewith
AU5785400A (en) 1999-07-02 2001-01-22 Symyx Technologies, Inc. Polymer brushes for immobilizing molecules to a surface or substrate, where the polymers have water-soluble or water-dispersible segments and probes bonded thereto
KR100883079B1 (ko) 1999-07-05 2009-02-10 노파르티스 아게 플랫폼, 플랫폼을 가지는 장치, 및 플랫폼을 사용하는 방법
US6771376B2 (en) * 1999-07-05 2004-08-03 Novartis Ag Sensor platform, apparatus incorporating the platform, and process using the platform
JP3727882B2 (ja) * 1999-07-07 2005-12-21 マイラス コーポレーション 固体支持体への核酸固定化用担体
ATE417127T1 (de) 1999-07-26 2008-12-15 Clinical Micro Sensors Inc Nukelinsäuresequenzbestimmung mittels elektronischem nachweis
EP1212458A4 (de) * 1999-07-30 2005-01-05 Surromed Inc Instrumente, verfahren und reagenzien, geeignet zur bestimmung mittels oberflächenplasmonresonanz
GB9923644D0 (en) 1999-10-06 1999-12-08 Medical Biosystems Ltd DNA sequencing
US6908736B1 (en) 1999-10-06 2005-06-21 Medical Biosystems, Ltd. DNA sequencing method
US8111401B2 (en) 1999-11-05 2012-02-07 Robert Magnusson Guided-mode resonance sensors employing angular, spectral, modal, and polarization diversity for high-precision sensing in compact formats
US7167615B1 (en) 1999-11-05 2007-01-23 Board Of Regents, The University Of Texas System Resonant waveguide-grating filters and sensors and methods for making and using same
US6399295B1 (en) 1999-12-17 2002-06-04 Kimberly-Clark Worldwide, Inc. Use of wicking agent to eliminate wash steps for optical diffraction-based biosensors
AU2767001A (en) * 2000-01-06 2001-07-16 Motorola, Inc. Three-dimensional network for biomolecule detection
GB0000209D0 (en) 2000-01-07 2000-03-01 Holmetrica Limited Holographic multiplexed image sensor
US7998412B2 (en) 2000-01-07 2011-08-16 Smart Holograms Limited Ophthalmic device comprising a holographic sensor
US6728429B1 (en) 2000-02-16 2004-04-27 Biotell, Inc. Optical detection
US6824669B1 (en) * 2000-02-17 2004-11-30 Motorola, Inc. Protein and peptide sensors using electrical detection methods
US6541071B1 (en) * 2000-03-23 2003-04-01 Corning Incorporated Method for fabricating supported bilayer-lipid membranes
US8399383B2 (en) 2000-05-04 2013-03-19 Yale University Protein chips for high throughput screening of protein activity
DE10027776A1 (de) * 2000-06-07 2002-02-14 Roche Diagnostics Gmbh Neuartige core-shell Partikel
JP4382265B2 (ja) * 2000-07-12 2009-12-09 日本電気株式会社 酸化シリコン膜の形成方法及びその形成装置
WO2002006373A1 (en) * 2000-07-17 2002-01-24 University Of Utah Research Foundation Hydrogel films and methods of making and using therefor
EP1348125A1 (de) * 2000-10-26 2003-10-01 Glaucus Proteomics B.V. Produkte mit biofunktioneller beschichtung
US7300803B2 (en) * 2000-10-30 2007-11-27 Sru Biosystems, Inc. Label-free methods for performing assays using a colorimetric resonant reflectance optical biosensor
US7142296B2 (en) * 2000-10-30 2006-11-28 Sru Biosystems, Inc. Method and apparatus for detecting biomolecular interactions
US7094595B2 (en) * 2000-10-30 2006-08-22 Sru Biosystems, Inc. Label-free high-throughput optical technique for detecting biomolecular interactions
US7023544B2 (en) * 2000-10-30 2006-04-04 Sru Biosystems, Inc. Method and instrument for detecting biomolecular interactions
US7371562B2 (en) 2000-10-30 2008-05-13 Sru Biosystems, Inc. Guided mode resonant filter biosensor using a linear grating surface structure
US7306827B2 (en) 2000-10-30 2007-12-11 Sru Biosystems, Inc. Method and machine for replicating holographic gratings on a substrate
US20030092075A1 (en) * 2000-10-30 2003-05-15 Sru Biosystems, Llc Aldehyde chemical surface activation processes and test methods for colorimetric resonant sensors
US7153702B2 (en) * 2000-10-30 2006-12-26 Sru Biosystems, Inc. Label-free methods for performing assays using a colorimetric resonant reflectance optical biosensor
US7264973B2 (en) * 2000-10-30 2007-09-04 Sru Biosystems, Inc. Label-free methods for performing assays using a colorimetric resonant optical biosensor
US7575939B2 (en) 2000-10-30 2009-08-18 Sru Biosystems, Inc. Optical detection of label-free biomolecular interactions using microreplicated plastic sensor elements
US7217574B2 (en) * 2000-10-30 2007-05-15 Sru Biosystems, Inc. Method and apparatus for biosensor spectral shift detection
US7175980B2 (en) 2000-10-30 2007-02-13 Sru Biosystems, Inc. Method of making a plastic colorimetric resonant biosensor device with liquid handling capabilities
US7875434B2 (en) 2000-10-30 2011-01-25 Sru Biosystems, Inc. Label-free methods for performing assays using a colorimetric resonant reflectance optical biosensor
US7070987B2 (en) * 2000-10-30 2006-07-04 Sru Biosystems, Inc. Guided mode resonant filter biosensor using a linear grating surface structure
US6951715B2 (en) * 2000-10-30 2005-10-04 Sru Biosystems, Inc. Optical detection of label-free biomolecular interactions using microreplicated plastic sensor elements
US7101660B2 (en) 2000-10-30 2006-09-05 Sru Biosystems, Inc. Method for producing a colorimetric resonant reflection biosensor on rigid surfaces
US7615339B2 (en) 2000-10-30 2009-11-10 Sru Biosystems, Inc. Method for producing a colorimetric resonant reflection biosensor on rigid surfaces
US20030113766A1 (en) * 2000-10-30 2003-06-19 Sru Biosystems, Llc Amine activated colorimetric resonant biosensor
US7202076B2 (en) 2000-10-30 2007-04-10 Sru Biosystems, Inc. Label-free high-throughput optical technique for detecting biomolecular interactions
US6686431B2 (en) * 2000-11-01 2004-02-03 Avery Dennison Corporation Optical coating having low refractive index
EP1330649A1 (de) * 2000-11-02 2003-07-30 Jandratek GmbH Oberflächen mit kovalent gebundenem hydrophilem spacer an hydrogelen
US20050084908A1 (en) * 2000-11-06 2005-04-21 Chugai Seiyaku Kabushiki Kaisha Methods for detecting binding of low-molecular-weight compound and its binding partner molecule
US6967074B2 (en) * 2000-11-08 2005-11-22 Surface Logix, Inc. Methods of detecting immobilized biomolecules
US7351575B2 (en) * 2000-11-08 2008-04-01 Surface Logix, Inc. Methods for processing biological materials using peelable and resealable devices
US6803205B2 (en) * 2000-11-08 2004-10-12 Surface Logix, Inc. Methods of measuring enzyme activity using peelable and resealable devices
US7371563B2 (en) 2000-11-08 2008-05-13 Surface Logix, Inc. Peelable and resealable devices for biochemical assays
US7001740B2 (en) * 2000-11-08 2006-02-21 Surface Logix, Inc. Methods of arraying biological materials using peelable and resealable devices
US7439056B2 (en) 2000-11-08 2008-10-21 Surface Logix Inc. Peelable and resealable devices for arraying materials
US8641644B2 (en) 2000-11-21 2014-02-04 Sanofi-Aventis Deutschland Gmbh Blood testing apparatus having a rotatable cartridge with multiple lancing elements and testing means
FR2818378B1 (fr) * 2000-12-14 2003-06-13 Commissariat Energie Atomique Dispositif de renforcement de fluorescence large bande a faibles pertes et capteur optique biologique ou chimique l'utilisant
DE10062173C1 (de) * 2000-12-14 2002-08-08 Inst Chemo Biosensorik Verfahren zur Bestimmung von Analytkonzentrationen
US7205161B2 (en) 2001-01-10 2007-04-17 Symyx Technologies, Inc. Polymer brushes for immobilizing molecules to a surface or substrate having improved stability
WO2002079761A1 (en) * 2001-04-02 2002-10-10 Prolinx Incorporated Systems and apparatus for the analysis of molecular interactions
WO2002078947A1 (en) * 2001-04-02 2002-10-10 Prolinx Incorporated Sensor surfaces for detecting analytes
US6730487B2 (en) * 2001-04-03 2004-05-04 Trustees Of Columbia University In The City Of New York Surface plasmon resonance biosensor for measurement of anti-glycolipid antibody levels in neuropathy
US20020192841A1 (en) * 2001-04-27 2002-12-19 Masayoshi Kojima Measurement chip for biosensor
WO2002090988A1 (de) * 2001-05-09 2002-11-14 Jandratek Gmbh Gegenstand mit einer ungeladenen, funktionalisierten hydrogeloberfläche
US6825032B2 (en) * 2001-05-14 2004-11-30 Sigma-Aldrich Co. High capacity assay platforms
CA2448902C (en) 2001-06-12 2010-09-07 Pelikan Technologies, Inc. Self optimizing lancing device with adaptation means to temporal variations in cutaneous properties
DE60234597D1 (de) 2001-06-12 2010-01-14 Pelikan Technologies Inc Gerät und verfahren zur entnahme von blutproben
US9226699B2 (en) 2002-04-19 2016-01-05 Sanofi-Aventis Deutschland Gmbh Body fluid sampling module with a continuous compression tissue interface surface
US7041068B2 (en) 2001-06-12 2006-05-09 Pelikan Technologies, Inc. Sampling module device and method
US7749174B2 (en) 2001-06-12 2010-07-06 Pelikan Technologies, Inc. Method and apparatus for lancet launching device intergrated onto a blood-sampling cartridge
US7981056B2 (en) 2002-04-19 2011-07-19 Pelikan Technologies, Inc. Methods and apparatus for lancet actuation
US8337419B2 (en) 2002-04-19 2012-12-25 Sanofi-Aventis Deutschland Gmbh Tissue penetration device
US9795747B2 (en) 2010-06-02 2017-10-24 Sanofi-Aventis Deutschland Gmbh Methods and apparatus for lancet actuation
US7344507B2 (en) 2002-04-19 2008-03-18 Pelikan Technologies, Inc. Method and apparatus for lancet actuation
US7033371B2 (en) 2001-06-12 2006-04-25 Pelikan Technologies, Inc. Electric lancet actuator
US7699791B2 (en) 2001-06-12 2010-04-20 Pelikan Technologies, Inc. Method and apparatus for improving success rate of blood yield from a fingerstick
SE0102331D0 (sv) * 2001-06-29 2001-06-29 Biacore Ab Flow cell method
FR2828491B1 (fr) * 2001-08-07 2003-10-10 Warner Lambert Co Nouvelle membrane supportee, preparation et utilisations
US20030040027A1 (en) * 2001-08-16 2003-02-27 Gerd Ritter Method for determining protein component in a biological sample
JP4435454B2 (ja) * 2001-09-03 2010-03-17 富士フイルム株式会社 バイオセンサー用表面
JP2003075447A (ja) 2001-09-03 2003-03-12 Fuji Photo Film Co Ltd 表面プラズモン共鳴バイオセンサー用測定チップ
FI118061B (fi) * 2001-09-24 2007-06-15 Beanor Oy Menetelmä ja bioanturi analyysiä varten
NL1019317C2 (nl) * 2001-11-06 2003-05-07 Tno Detectie van een geladen deeltje.
DE10153954A1 (de) * 2001-11-06 2003-05-22 Preventor U Tbc Gmbh Schicht mit selektiv perfluorierter Oberfläche
DE10220602A1 (de) * 2001-11-28 2003-06-26 Graffinity Pharmaceuticals Ag Verfahren zur Selektion und Identifikation von Peptid- oder Proteinmolekülen mittels Phage Display
EP1453959A2 (de) * 2001-11-28 2004-09-08 Graffinity Pharmaceuticals Aktiengesellschaft Verfahren zur selektion und identifikation von peptid- oder proteinmolekülen mittels phage display
EP1451558A1 (de) * 2001-11-28 2004-09-01 Graffinity Pharmaceuticals Aktiengesellschaft Spr-sensorflächenträger
US7129096B2 (en) * 2001-12-11 2006-10-31 Duke University Sensor for use in testing biological, biochemical, chemical or environmental samples
US7098041B2 (en) 2001-12-11 2006-08-29 Kimberly-Clark Worldwide, Inc. Methods to view and analyze the results from diffraction-based diagnostics
US7102752B2 (en) 2001-12-11 2006-09-05 Kimberly-Clark Worldwide, Inc. Systems to view and analyze the results from diffraction-based diagnostics
EP1456659B1 (de) * 2001-12-21 2008-03-12 GE Healthcare Bio-Sciences AB Immobilisierung von bindungsstoffen
US6837171B1 (en) 2002-04-29 2005-01-04 Palmer/Snyder Furniture Company Lightweight table with unitized table top
US8367013B2 (en) 2001-12-24 2013-02-05 Kimberly-Clark Worldwide, Inc. Reading device, method, and system for conducting lateral flow assays
US20030119203A1 (en) 2001-12-24 2003-06-26 Kimberly-Clark Worldwide, Inc. Lateral flow assay devices and methods for conducting assays
FI115166B (fi) 2001-12-31 2005-03-15 Biofons Oy Diagnostisia menetelmiä
US20030153026A1 (en) * 2002-01-04 2003-08-14 Javier Alarcon Entrapped binding protein as biosensors
US20050239155A1 (en) * 2002-01-04 2005-10-27 Javier Alarcon Entrapped binding protein as biosensors
CA2472188C (en) * 2002-01-18 2011-06-21 Control Delivery Systems, Inc. Polymeric gel system for the controlled delivery of codrugs
AU2003244342A1 (en) * 2002-01-29 2003-09-02 Asahi Kasei Kabushiki Kaisha Biosensor, magnetic molecule measurement method, and measurement object measuring method
NL1020090C2 (nl) * 2002-02-28 2003-08-29 Tno Nieuwe coating voor biosensoren.
AU2003218831A1 (en) * 2002-03-04 2003-09-16 Glaucus Proteomics B.V. Matrix for coupling of a biological molecule, method for producing and use of said matrix
EP1343010A1 (de) * 2002-03-04 2003-09-10 Glaucus Proteomics B.V. Matrix zur Immobilisierung von biologischen Substanzen, sowie Verfahren zur Herstellung und Verwending derartige Matrixen
US7419821B2 (en) 2002-03-05 2008-09-02 I-Stat Corporation Apparatus and methods for analyte measurement and immunoassay
WO2003076933A1 (fr) * 2002-03-11 2003-09-18 Toudai Tlo, Ltd. Surface en poly(ethylene oxyde) a structure de type pinceau presentant une densite elevee
SE0200949D0 (sv) * 2002-03-27 2002-03-27 Biacore Ab Method and system for curve quality control
JP4406287B2 (ja) * 2002-03-27 2010-01-27 ジーイー・ヘルスケア・バイオ−サイエンシーズ・アーベー 応答曲線の質の制御を包含する、分子結合相互作用の検出のための方法、システムおよびコンピュータプログラム
CA2480770A1 (en) * 2002-04-03 2003-10-09 Japan Science And Technology Agency Biochip sensor surface carrying polyethylene glycolated nanoparticles
US7892183B2 (en) 2002-04-19 2011-02-22 Pelikan Technologies, Inc. Method and apparatus for body fluid sampling and analyte sensing
US8267870B2 (en) 2002-04-19 2012-09-18 Sanofi-Aventis Deutschland Gmbh Method and apparatus for body fluid sampling with hybrid actuation
US7648468B2 (en) 2002-04-19 2010-01-19 Pelikon Technologies, Inc. Method and apparatus for penetrating tissue
US7371247B2 (en) 2002-04-19 2008-05-13 Pelikan Technologies, Inc Method and apparatus for penetrating tissue
US7491178B2 (en) 2002-04-19 2009-02-17 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US7976476B2 (en) 2002-04-19 2011-07-12 Pelikan Technologies, Inc. Device and method for variable speed lancet
US9314194B2 (en) 2002-04-19 2016-04-19 Sanofi-Aventis Deutschland Gmbh Tissue penetration device
US7297122B2 (en) 2002-04-19 2007-11-20 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US7909778B2 (en) * 2002-04-19 2011-03-22 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US8372016B2 (en) 2002-04-19 2013-02-12 Sanofi-Aventis Deutschland Gmbh Method and apparatus for body fluid sampling and analyte sensing
US8579831B2 (en) 2002-04-19 2013-11-12 Sanofi-Aventis Deutschland Gmbh Method and apparatus for penetrating tissue
US7547287B2 (en) 2002-04-19 2009-06-16 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US8784335B2 (en) 2002-04-19 2014-07-22 Sanofi-Aventis Deutschland Gmbh Body fluid sampling device with a capacitive sensor
US8221334B2 (en) 2002-04-19 2012-07-17 Sanofi-Aventis Deutschland Gmbh Method and apparatus for penetrating tissue
US7226461B2 (en) 2002-04-19 2007-06-05 Pelikan Technologies, Inc. Method and apparatus for a multi-use body fluid sampling device with sterility barrier release
US7291117B2 (en) 2002-04-19 2007-11-06 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US7674232B2 (en) 2002-04-19 2010-03-09 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US7232451B2 (en) 2002-04-19 2007-06-19 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US7901362B2 (en) 2002-04-19 2011-03-08 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US7331931B2 (en) 2002-04-19 2008-02-19 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US8702624B2 (en) 2006-09-29 2014-04-22 Sanofi-Aventis Deutschland Gmbh Analyte measurement device with a single shot actuator
US8360992B2 (en) 2002-04-19 2013-01-29 Sanofi-Aventis Deutschland Gmbh Method and apparatus for penetrating tissue
US7229458B2 (en) 2002-04-19 2007-06-12 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US9795334B2 (en) 2002-04-19 2017-10-24 Sanofi-Aventis Deutschland Gmbh Method and apparatus for penetrating tissue
US7717863B2 (en) 2002-04-19 2010-05-18 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
AU2003265769A1 (en) * 2002-05-02 2003-11-17 Ciphergen Biosystems, Inc. Biochips with surfaces coated with polysaccharide based hydrogels
US7485453B2 (en) * 2002-05-03 2009-02-03 Kimberly-Clark Worldwide, Inc. Diffraction-based diagnostic devices
US7214530B2 (en) 2002-05-03 2007-05-08 Kimberly-Clark Worldwide, Inc. Biomolecule diagnostic devices and method for producing biomolecule diagnostic devices
US7223534B2 (en) 2002-05-03 2007-05-29 Kimberly-Clark Worldwide, Inc. Diffraction-based diagnostic devices
US7118855B2 (en) * 2002-05-03 2006-10-10 Kimberly-Clark Worldwide, Inc. Diffraction-based diagnostic devices
US7771922B2 (en) 2002-05-03 2010-08-10 Kimberly-Clark Worldwide, Inc. Biomolecule diagnostic device
US7223368B2 (en) 2002-05-03 2007-05-29 Kimberly-Clark Worldwide, Inc. Diffraction-based diagnostic devices
CA2483696A1 (en) * 2002-05-06 2003-11-20 University Of Utah Research Foundation Preblocking with non-ha gags increases effectiveness of ha conjugated anticancer agents
US8785179B2 (en) * 2002-05-22 2014-07-22 Texas Instruments Incorporated Biosensor and method
JP4468803B2 (ja) * 2002-05-31 2010-05-26 ジーイー・ヘルスケア・バイオ−サイエンシーズ・アーベー 結合剤を基板表面にカップリングさせる方法
US7879621B2 (en) 2003-05-08 2011-02-01 Phynexus, Inc. Open channel solid phase extraction systems and methods
US7122640B2 (en) * 2002-06-10 2006-10-17 Phynexus, Inc. Open channel solid phase extraction systems and methods
US7151167B2 (en) * 2002-06-10 2006-12-19 Phynexus, Inc. Open channel solid phase extraction systems and methods
US20040224329A1 (en) * 2003-05-08 2004-11-11 Gjerde Douglas T. Three-dimensional solid phase extraction surfaces
US7091049B2 (en) 2002-06-26 2006-08-15 Kimberly-Clark Worldwide, Inc. Enhanced diffraction-based biosensor devices
US7285424B2 (en) 2002-08-27 2007-10-23 Kimberly-Clark Worldwide, Inc. Membrane-based assay devices
US7314763B2 (en) 2002-08-27 2008-01-01 Kimberly-Clark Worldwide, Inc. Fluidics-based assay devices
US20040043508A1 (en) * 2002-09-03 2004-03-04 Frutos Anthony G. Polymer-coated substrates for binding biological molecules
US7927822B2 (en) 2002-09-09 2011-04-19 Sru Biosystems, Inc. Methods for screening cells and antibodies
US7429492B2 (en) * 2002-09-09 2008-09-30 Sru Biosystems, Inc. Multiwell plates with integrated biosensors and membranes
US7169550B2 (en) * 2002-09-26 2007-01-30 Kimberly-Clark Worldwide, Inc. Diffraction-based diagnostic devices
GB2393704B (en) * 2002-10-02 2006-03-15 Aircraft Materials Ltd Improvements to an aerial delivery system and restraint assembly therefor
US7781172B2 (en) 2003-11-21 2010-08-24 Kimberly-Clark Worldwide, Inc. Method for extending the dynamic detection range of assay devices
US7309614B1 (en) 2002-12-04 2007-12-18 Sru Biosystems, Inc. Self-referencing biodetection method and patterned bioassays
US7247500B2 (en) 2002-12-19 2007-07-24 Kimberly-Clark Worldwide, Inc. Reduction of the hook effect in membrane-based assay devices
US8574895B2 (en) 2002-12-30 2013-11-05 Sanofi-Aventis Deutschland Gmbh Method and apparatus using optical techniques to measure analyte levels
US20040191815A1 (en) * 2003-01-15 2004-09-30 Motoki Kyo Array having oligonucleotides on a metal substrate
WO2004068141A1 (en) * 2003-01-22 2004-08-12 The Arizona Board Of Regents On Behalf Of The University Of Arizona Coupled plasmon-waveguide resonance spectroscopic sensors for pharmaceutical and chemical testing
WO2005016115A2 (en) * 2003-01-23 2005-02-24 Montana State University Biosensors utilizing dendrimer-immobilized ligands and their use thereof
US20070082019A1 (en) * 2003-02-21 2007-04-12 Ciphergen Biosystems Inc. Photocrosslinked hydrogel surface coatings
JP2004251807A (ja) * 2003-02-21 2004-09-09 Nipro Corp エンドトキシン測定用センサ、測定方法、診断方法、製造方法およびセンサ再生方法
US20040197819A1 (en) 2003-04-03 2004-10-07 Kimberly-Clark Worldwide, Inc. Assay devices that utilize hollow particles
US7851209B2 (en) 2003-04-03 2010-12-14 Kimberly-Clark Worldwide, Inc. Reduction of the hook effect in assay devices
WO2004097368A2 (en) * 2003-04-28 2004-11-11 Ciphergen Biosystems, Inc. Improved immunoassays
US20040241721A1 (en) * 2003-05-08 2004-12-02 Gjerde Douglas T. Open channel solid phase extraction systems and methods
ES2347248T3 (es) 2003-05-30 2010-10-27 Pelikan Technologies Inc. Procedimiento y aparato para la inyeccion de fluido.
WO2004107964A2 (en) 2003-06-06 2004-12-16 Pelikan Technologies, Inc. Blood harvesting device with electronic control
US20040248323A1 (en) 2003-06-09 2004-12-09 Protometrix, Inc. Methods for conducting assays for enzyme activity on protein microarrays
WO2006001797A1 (en) 2004-06-14 2006-01-05 Pelikan Technologies, Inc. Low pain penetrating
US20050048493A1 (en) * 2003-08-27 2005-03-03 Zyomyx, Inc. Film layer for detection of immobilized analytes
US20050053949A1 (en) * 2003-09-08 2005-03-10 Silin Vitalii Ivanovich Biochip for proteomics applications
JP4363935B2 (ja) * 2003-09-17 2009-11-11 株式会社豊田中央研究所 生体物質の光固定化・回収方法及び表面プラズモン共鳴センサー
US8298780B2 (en) * 2003-09-22 2012-10-30 X-Body, Inc. Methods of detection of changes in cells
SE0302525D0 (sv) * 2003-09-24 2003-09-24 Biacore Ab Method and system for interaction analysis
WO2005029077A1 (en) * 2003-09-24 2005-03-31 Biacore Ab Method and system for molecular interaction analysis
US20050130226A1 (en) * 2003-09-26 2005-06-16 The University Of Cincinnati Fully integrated protein lab-on-a-chip with smart microfluidics for spot array generation
WO2005033659A2 (en) 2003-09-29 2005-04-14 Pelikan Technologies, Inc. Method and apparatus for an improved sample capture device
US9351680B2 (en) 2003-10-14 2016-05-31 Sanofi-Aventis Deutschland Gmbh Method and apparatus for a variable user interface
CA2544836A1 (en) * 2003-11-06 2005-05-26 Guo Bin Wang High-density amine-functionalized surface
JP4796967B2 (ja) 2003-11-07 2011-10-19 ヴァーミリオン インコーポレイテッド アルツハイマー病のためのバイオマーカー
US7713748B2 (en) 2003-11-21 2010-05-11 Kimberly-Clark Worldwide, Inc. Method of reducing the sensitivity of assay devices
US7943395B2 (en) 2003-11-21 2011-05-17 Kimberly-Clark Worldwide, Inc. Extension of the dynamic detection range of assay devices
US20050112703A1 (en) 2003-11-21 2005-05-26 Kimberly-Clark Worldwide, Inc. Membrane-based lateral flow assay devices that utilize phosphorescent detection
DE602004004753T2 (de) * 2003-11-28 2008-01-31 C.S.E.M. Centre Suisse D'electronique Et De Microtechnique S.A. Photolinker-makromoleküle, mit den linkern modifizierte metallische substrate und liganden sowie verfahren zur herstellung davon
CA2548179A1 (en) 2003-12-02 2005-07-21 Cytimmune Sciences, Inc. Methods and compositions for the production of monoclonal antibodies
US20050181497A1 (en) * 2003-12-04 2005-08-18 Fuji Photo Film Co., Ltd. Solid substrate used for sensors
CA2547861A1 (en) 2003-12-05 2005-06-23 Ciphergen Biosystems, Inc. Serum biomarkers for chagas disease
US7943089B2 (en) 2003-12-19 2011-05-17 Kimberly-Clark Worldwide, Inc. Laminated assay devices
US7501289B2 (en) * 2003-12-25 2009-03-10 Fujifilm Corporation Biosensor
JP2005189198A (ja) * 2003-12-26 2005-07-14 Fuji Photo Film Co Ltd 光学デバイス
EP1706026B1 (de) 2003-12-31 2017-03-01 Sanofi-Aventis Deutschland GmbH Verfahren und vorrichtung zur verbesserung der fluidströmung und der probennahme
US7822454B1 (en) 2005-01-03 2010-10-26 Pelikan Technologies, Inc. Fluid sampling device with improved analyte detecting member configuration
EP1715971A4 (de) * 2004-01-28 2010-10-13 Cytimmune Sciences Inc Funktionalisierte kolloidale metallzusammensetzungen und verfahren
US20050233378A1 (en) * 2004-03-26 2005-10-20 Fuji Photo Film Co., Ltd. Biosensor
WO2006104498A2 (en) * 2004-04-20 2006-10-05 University Of Rochester Hydrogel-supported porous semiconductor devices
BRPI0510266A (pt) 2004-04-26 2007-10-30 Childrens Medical Center métodos para a detecção de uma doença ou distúrbio angiogênico em um indivìduo, para a detecção de cáncer em um indivìduo, para o tratamento de um indivìduo afetado com uma doença ou distúrbio angiogênico, para a determinação da probabilidade de eficácia de uma terapia anti-angiogênica, para a determinação da eficácia de uma terapia de teste na modulação dos nìveis de reguladores angiogênicos de plaqueta, para a criação de um registro ou perfil de plaqueta para uma doença ou distúrbio angiogênico e para a monitoração da eficácia de uma terapia em um indivìduo com uma doença ou distúrbio angiogênico
US8828203B2 (en) 2004-05-20 2014-09-09 Sanofi-Aventis Deutschland Gmbh Printable hydrogels for biosensors
AU2005245996A1 (en) 2004-05-21 2005-12-01 Atonomics A/S Surface acoustic wave sensor comprising a hydrogel
US7470549B2 (en) * 2004-05-26 2008-12-30 Fujifilm Corporation Measurement method using biosensor
US7323347B2 (en) * 2004-05-27 2008-01-29 Sensata Technologies, Inc. Biosensor surface structures and methods
US20050265648A1 (en) * 2004-06-01 2005-12-01 Daniel Roitman Evanescent wave sensor containing nanostructures and methods of using the same
US9775553B2 (en) 2004-06-03 2017-10-03 Sanofi-Aventis Deutschland Gmbh Method and apparatus for a fluid sampling device
US9820684B2 (en) 2004-06-03 2017-11-21 Sanofi-Aventis Deutschland Gmbh Method and apparatus for a fluid sampling device
JP4799557B2 (ja) * 2004-06-09 2011-10-26 ベクトン・ディキンソン・アンド・カンパニー 多検体センサー
GB0413082D0 (en) 2004-06-11 2004-07-14 Medical Biosystems Ltd Method
US7521226B2 (en) 2004-06-30 2009-04-21 Kimberly-Clark Worldwide, Inc. One-step enzymatic and amine detection technique
US20070009198A1 (en) * 2004-07-02 2007-01-11 Robert Petcavich Fiber optic bio-sensor
JP2006046984A (ja) * 2004-08-02 2006-02-16 Fuji Photo Film Co Ltd バイオセンサー
US20060068424A1 (en) * 2004-08-13 2006-03-30 Fuji Photo Film Co., Ltd. Biosensor
GB0420062D0 (en) * 2004-09-09 2004-10-13 Akubio Ltd Assay methods,materials and preparations
US8183057B2 (en) * 2004-09-14 2012-05-22 Mitsubishi Chemical Corporation Biomaterial construct, its producing method, biomaterial support, target material purifying method, affinity chromatography container, separation chip, analyzing method and analyzing separator for target material, biomaterial complex, and its support, sensor chip, solid support with biomaterial fixed thereon
US20060073534A1 (en) * 2004-10-05 2006-04-06 The University Of Georgia Research Foundation, Inc Method for cleaving and deglycosylating antibodies to promote ligand binding
SE0402476D0 (sv) * 2004-10-13 2004-10-13 Biacore Ab Preparation and use of a reactive solid support surface
JP2006153831A (ja) * 2004-10-27 2006-06-15 Mitsubishi Chemicals Corp カンチレバーセンサ、センサシステム及び検体液中の検出対象物質の検出方法
US20070149775A1 (en) * 2004-11-23 2007-06-28 Hans Sigrist Photolinker Macromolecules, Metallic Substrates and Ligands Modified with Said Linkers, and Process of Preparation thereof
US20060110594A1 (en) * 2004-11-24 2006-05-25 Frutos Anthony G Polymer-coated substrates for binding biomolecules and methods of making and using thereof
US20060128031A1 (en) * 2004-12-15 2006-06-15 Robotti Karla M Addressable recovery of bound analytes from an evanescent wave sensor
KR100597788B1 (ko) * 2004-12-17 2006-07-06 삼성전자주식회사 프로그램 동작 속도를 개선하는 불휘발성 반도체 메모리장치의 페이지 버퍼와 이에 대한 구동방법
US7349080B2 (en) * 2004-12-30 2008-03-25 Corning Incorporated Label-independent detection of unpurified analytes
US8652831B2 (en) 2004-12-30 2014-02-18 Sanofi-Aventis Deutschland Gmbh Method and apparatus for analyte measurement test time
US7811772B2 (en) * 2005-01-06 2010-10-12 Eastern Virginia Medical School Apolipoprotein A-II isoform as a biomarker for prostate cancer
US7245370B2 (en) * 2005-01-06 2007-07-17 Hewlett-Packard Development Company, L.P. Nanowires for surface-enhanced Raman scattering molecular sensors
AU2006200582B2 (en) * 2005-02-23 2008-09-25 Aisin Seiki Kabushiki Kaisha Door lock apparatus for a vehicle
DE602006009980D1 (de) * 2005-02-23 2009-12-10 Fujifilm Corp Biosensor
JP4270511B2 (ja) * 2005-02-28 2009-06-03 富士フイルム株式会社 バイオセンサー
US7397558B2 (en) * 2005-03-17 2008-07-08 Hewlett-Packard Development Company, L.P. Ordered array of nanoparticles for efficient nanoenhanced Raman scattering detection and methods of forming the same
JP4435709B2 (ja) * 2005-03-22 2010-03-24 富士フイルム株式会社 バイオセンサー
JP4435708B2 (ja) * 2005-03-22 2010-03-24 富士フイルム株式会社 バイオセンサー
US7292334B1 (en) * 2005-03-25 2007-11-06 Hewlett-Packard Development Company, L.P. Binary arrays of nanoparticles for nano-enhanced Raman scattering molecular sensors
US20060223184A1 (en) * 2005-04-05 2006-10-05 Frutos Anthony G Supports useful in incorporating biomolecules into cells and methods of using thereof
US20070196833A1 (en) * 2005-04-21 2007-08-23 Gjerde Douglas T Open channel solid phase extraction systems and methods
US7611908B2 (en) 2005-05-02 2009-11-03 Bioscale, Inc. Method and apparatus for therapeutic drug monitoring using an acoustic device
US7300631B2 (en) 2005-05-02 2007-11-27 Bioscale, Inc. Method and apparatus for detection of analyte using a flexural plate wave device and magnetic particles
US7648844B2 (en) 2005-05-02 2010-01-19 Bioscale, Inc. Method and apparatus for detection of analyte using an acoustic device
US7749445B2 (en) * 2005-05-02 2010-07-06 Bioscale, Inc. Method and apparatus for analyzing bioprocess fluids
EP1724584A1 (de) * 2005-05-19 2006-11-22 Agilent Technologies, Inc. Evaneszenzwellenmesser mit angehängtem Ligand
CN101198866A (zh) * 2005-05-20 2008-06-11 皇家墨尔本理工大学 化验装置
JP2006329631A (ja) * 2005-05-23 2006-12-07 Hitachi Ltd 分子間相互作用検出装置およびそれを用いた分子回収装置
US7396676B2 (en) 2005-05-31 2008-07-08 Agilent Technologies, Inc. Evanescent wave sensor with attached ligand
WO2006132224A1 (ja) * 2005-06-09 2006-12-14 Tokyo University Of Agriculture And Technology 反射率変化型センサ、光学式測定装置、反射率変化型センサの製造方法、並びに反射率変化型センサ用自己組織化微粒子単層膜、自己組織化微粒子単層膜及びこれら単層膜の製造方法
US20070016378A1 (en) * 2005-06-13 2007-01-18 Biacore Ab Method and system for affinity analysis
EP1904852A2 (de) 2005-06-24 2008-04-02 Ciphergen Biosystems, Inc. Biomarker für ovarialkarzinom: beta-2-mikroglobulin
JP2007057458A (ja) * 2005-08-26 2007-03-08 Fujifilm Corp バイオセンサー
US20070048747A1 (en) * 2005-09-01 2007-03-01 Leslie Thomas M Methods for assaying analytes
US7342656B2 (en) * 2005-10-17 2008-03-11 Hewlett-Packard Development Company, L.P. Dynamically variable separation among nanoparticles for nano-enhanced Raman spectroscopy (NERS) molecular sensing
US7372562B2 (en) * 2005-10-17 2008-05-13 Hewlett-Packard Development Company, L.P. Dynamic random separation among nanoparticles for nano enhanced Raman spectroscopy (NERS) molecular sensing
CN101341409B (zh) * 2005-10-27 2012-11-28 生物辐射海法有限公司 结合层及其制备方法和用途
US20070117152A1 (en) * 2005-11-08 2007-05-24 Fujifilm Corporation Biosensor
ES2356080T3 (es) * 2005-11-10 2011-04-04 Bristol-Myers Squibb Pharma Company Moesina, caveolina y proteina 1 asociada a yes como marcadores de respuesta a dasatinib en canceres de mama.
US7889347B2 (en) 2005-11-21 2011-02-15 Plexera Llc Surface plasmon resonance spectrometer with an actuator driven angle scanning mechanism
US8227261B2 (en) * 2005-11-23 2012-07-24 Bioscale, Inc. Methods and apparatus for assay measurements
EP1790984B1 (de) 2005-11-25 2013-08-28 FUJIFILM Corporation Verfahren zur Herstellung eines Biosensors mit einer dünnen und kovalent verbundenen Polymerschicht
US7463358B2 (en) 2005-12-06 2008-12-09 Lumera Corporation Highly stable surface plasmon resonance plates, microarrays, and methods
WO2007070809A2 (en) * 2005-12-12 2007-06-21 Mcgill University Biomarkers for babesia
US7781203B2 (en) * 2005-12-29 2010-08-24 Corning Incorporated Supports for assaying analytes and methods of making and using thereof
CA2640614A1 (en) * 2006-01-27 2007-08-09 Eastern Virginia Medical School Proteomic fingerprinting of human ivf-derived embryos: identification of biomarkers of developmental potential
US20070176728A1 (en) * 2006-01-31 2007-08-02 Ranganath Tirumala R Tiled periodic metal film sensors
EP1826563A1 (de) * 2006-02-22 2007-08-29 Fujifilm Corporation Biosensor
US20070196233A1 (en) * 2006-02-23 2007-08-23 Fujifilm Corporation Biosensor and method for immobilizing a physiologically active substance
EP1996949A4 (de) 2006-03-11 2010-01-20 Univ Leland Stanford Junior Beta-2 mikroglobulin als biomarker für periphere arterienerkrankung
GB0605302D0 (en) * 2006-03-16 2006-04-26 Akubio Ltd Improvements in or relating to coating surfaces
US8080430B2 (en) * 2006-04-25 2011-12-20 Canon Kabushiki Kaisha Target substance detection material and method and kit for detecting target substance
US7511808B2 (en) * 2006-04-27 2009-03-31 Hewlett-Packard Development Company, L.P. Analyte stages including tunable resonant cavities and Raman signal-enhancing structures
EP2064375B1 (de) * 2006-06-06 2012-11-21 Société de Commercialisation des Produits de la Recherche Appliquée - SOCPRA- Sciences et Génie s.e.c. Assayträger, umfassend einen peg-träger, wobei der träger aus einer peg-lösung unter trübungspunktbedingungen (theta-lösungsmittel) gebunden wird
AU2007273055B2 (en) 2006-07-14 2014-05-01 The Regents Of The University Of California Cancer biomarkers and methods of use thereof
US20100279422A1 (en) * 2006-08-21 2010-11-04 Cmed Technologies Ltd. Method of surface plasmon resonance (spr) technology to detect genomic disorders for prenatal diagnosis
WO2008033073A1 (en) * 2006-09-14 2008-03-20 Ge Healthcare Bio-Sciences Ab A method of determining analyte concentration
US20100086920A1 (en) * 2006-09-18 2010-04-08 Cmed Technologies Ltd. Method to assess cancer susceptibility and differential diagnosis of metastases of unknown primary tumors
GB2454852B (en) * 2006-09-19 2011-06-29 Limited Cmed Technologies A method for screening of infectious agents in blood
WO2008070223A2 (en) * 2006-09-21 2008-06-12 Cmed Technologies Ltd. A method to remove repetitive sequences from human dna
US20100047815A1 (en) * 2006-09-21 2010-02-25 Cmed Technologies Ltd. Method to detect tumor markers and diagnosis of undifferentiated tumors
WO2008082710A2 (en) * 2006-09-25 2008-07-10 Cmed Technologies Ltd. A method of surface plasmon resonance (spr) technology to detect genomic aberrations in patients with multiple myeloma
WO2008094312A2 (en) * 2006-09-25 2008-08-07 Cmed Technologies Ltd. A method of surface plasmon resonance (spr) technology to detect genomic disorders for postnatal diagnosis
WO2008057652A2 (en) * 2006-09-25 2008-05-15 Cmed Technologies Ltd. A method to detect virus related immunological markers for the diagnosis of hepatitis c virus infection
US20090311699A1 (en) * 2006-09-25 2009-12-17 Cmed Technologies Ltd. Method of surface plasmon resonance (spr) to detect genomic aberrations in patients with chronic lymphocytic leukemia
WO2008085554A2 (en) * 2006-09-25 2008-07-17 Cmed Technologies Ltd. A method to detect virus related immunologigal markers for the diagnosis of hepatitis b virus infection
US8158342B2 (en) * 2006-09-25 2012-04-17 Cmed Technologies Ltd. Method for the identification of human immunodeficiency virus related antibodies in blood
WO2008067003A2 (en) * 2006-09-27 2008-06-05 Cmed Technologies Ltd. A method to detect virus related immunological markers for the diagnosis of respiratory tract infections
WO2008066997A2 (en) * 2006-09-27 2008-06-05 Cmed Technologies Ltd. A method for quantitative measurement of cardiac biochemical markers
WO2008066994A2 (en) * 2006-09-27 2008-06-05 Cmed Technologies Ltd. Application of surface plasmon resonance technology to maternal serum screening for congenital birth defects
US20100086937A1 (en) * 2006-09-27 2010-04-08 Cmed Technologies Ltd. method to detect treponema pallidum immunological markers for the diagnosis of syphilis
US8110409B2 (en) * 2006-09-27 2012-02-07 Cmed Technologies Ltd. Method to measure serum biomarkers for the diagnosis of liver fibrosis
WO2008067008A2 (en) * 2006-09-27 2008-06-05 Cmed Technologies Ltd. A method for the quantitative evaluation of sex hormones in a serum sample
US8110408B2 (en) * 2006-09-28 2012-02-07 Cmed Technologies Ltd. Method for quantitative detection of diabetes related immunological markers
WO2008067007A2 (en) * 2006-09-28 2008-06-05 Cmed Technologies Ltd. A method for quantitative measurement of thyroid homrones and related antibodies in a serum sample
JP2008107315A (ja) * 2006-09-29 2008-05-08 Fujifilm Corp 生体分子の固定化方法
JP2008286775A (ja) * 2007-01-31 2008-11-27 Fujifilm Corp 生理活性物質固定基板の製造方法及び基板
US20080187977A1 (en) * 2007-01-31 2008-08-07 Fujifilm Corporation Method for production of physiologically active substance-immobilized substrate
US20080188010A1 (en) 2007-02-01 2008-08-07 Fujifilm Corporation Biosensor substrate
CN101261226B (zh) * 2007-03-08 2010-12-08 北京宏荣博曼生物科技有限责任公司 一种基于聚乙二醇的表面等离子共振仪芯片
AU2008236810A1 (en) 2007-03-27 2008-10-16 Board Of Regents Of The University Of Texas System Biomarkers for ovarian cancer
JP2008249502A (ja) 2007-03-30 2008-10-16 Fujifilm Corp 生理活性物質を固定化した固体基板
US20080299673A1 (en) * 2007-04-19 2008-12-04 Sru Biosystems, Inc. Method for Employing a Biosensor to Detect Small Molecules ("Fragments") that Bind Directly to Immobilized Protein Targets
EP2160478B1 (de) * 2007-06-06 2014-08-27 Siemens Healthcare Diagnostics Inc. Prognostische diagnose von nierenerkrankungen
CA2693700A1 (en) 2007-07-11 2009-01-15 Sru Biosystems, Inc. Methods for identifying modulators of ion channels
US9134307B2 (en) 2007-07-11 2015-09-15 X-Body, Inc. Method for determining ion channel modulating properties of a test reagent
EP2015071A1 (de) * 2007-07-13 2009-01-14 FUJIFILM Corporation Träger, Herstellungsverfahren dafür, Bioreaktor und Chip für die Oberflächenplasmon-Resonanzanalyse
JP2009063335A (ja) 2007-09-05 2009-03-26 Fujifilm Corp 生理活性物質と被験物質との相互作用の測定方法
US8354280B2 (en) * 2007-09-06 2013-01-15 Bioscale, Inc. Reusable detection surfaces and methods of using same
US20110014118A1 (en) * 2007-09-21 2011-01-20 Lawrence Tamarkin Nanotherapeutic colloidal metal compositions and methods
KR20100123674A (ko) * 2007-09-21 2010-11-24 싸이티뮨 사이언스, 인크. 나노치료제 콜로이드성 금속 조성물 및 방법
JP2009075016A (ja) 2007-09-21 2009-04-09 Fujifilm Corp バイオセンサーの製造方法及びバイオセンサー
JP5021408B2 (ja) * 2007-09-26 2012-09-05 富士フイルム株式会社 バイオセンサー
US8168379B2 (en) 2007-10-04 2012-05-01 Cmed Technologies Ltd. Application of surface plasmon resonance technology for detecting and genotyping HPV
CA2706700A1 (en) 2007-11-08 2009-05-14 Cytimmune Sciences, Inc. Compositions and methods for generating antibodies
FR2924225B1 (fr) * 2007-11-27 2016-12-09 Genoptics Biopuces fonctionnalisees pour le couplage spr-ms
CN101932728B (zh) 2007-11-30 2013-06-19 西门子医疗保健诊断公司 脂连蛋白受体片段和使用方法
JP2009145189A (ja) 2007-12-13 2009-07-02 Fujifilm Corp バイオセンサー
US8004669B1 (en) 2007-12-18 2011-08-23 Plexera Llc SPR apparatus with a high performance fluid delivery system
US20090227043A1 (en) * 2008-02-19 2009-09-10 Wei Huang Fluorescence Resonance Energy Transfer Assay Based on Modified Solid Surface
CA2718251A1 (en) 2008-03-10 2009-09-17 Lineagen, Inc. Copd biomarker signatures
WO2009118343A1 (en) * 2008-03-27 2009-10-01 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods and kits for determining the occurrence of a liver disease in a subject
US8257936B2 (en) 2008-04-09 2012-09-04 X-Body Inc. High resolution label free analysis of cellular properties
WO2009126900A1 (en) 2008-04-11 2009-10-15 Pelikan Technologies, Inc. Method and apparatus for analyte detecting device
BRPI0910482A2 (pt) 2008-04-29 2019-09-24 Abbott Lab imunoglobinas de domínio variável duplo e usos das mesmas
JP2009286968A (ja) * 2008-05-30 2009-12-10 Canon Inc グラフトポリマー含有基体、その製造方法および磁気バイオセンサ
AU2009255776A1 (en) * 2008-06-02 2009-12-10 Ge Healthcare Bio-Sciences Ab Method for virus detection
EP2297209A4 (de) 2008-06-03 2012-08-01 Abbott Lab Dual-variable- domain-immunglobuline und ihre verwendungen
CN102057044B (zh) * 2008-06-04 2013-05-01 泰勒克里斯生物治疗学公司 用于制备纤溶酶的组合物，方法以及试剂盒
WO2009149285A1 (en) * 2008-06-04 2009-12-10 Sru Biosystems, Inc. Detection of promiscuous small submicrometer aggregates
WO2010005364A1 (en) 2008-07-08 2010-01-14 Ge Healthcare Bio-Sciences Ab Separation medium for chromatography of various biomolecules
WO2010123720A1 (en) 2009-04-23 2010-10-28 Siemens Healthcare Diagnostics Inc. Monomeric and dimeric forms of adiponectin receptor fragments and methods of use
WO2010021586A1 (en) * 2008-08-22 2010-02-25 Ge Healthcare Bio-Sciences Ab A method of characterizing antibodies
EP2192410B1 (de) * 2008-11-26 2012-07-11 Corning Incorporated Erfassung der Nanoteilchenaffinität für etikettenunabhängige Detektionssysteme
EP2192409B1 (de) 2008-11-26 2014-04-23 Corning Incorporated Biosensorzusammensetzung zur Marker-unabhängigen Erkennung und Verfahren dafür
US8349325B2 (en) 2008-12-23 2013-01-08 Abbott Laboratories Soluble FMS-like tyrosine kinase-1 (sFLT-1) antibody and related composition, kit, methods of using, and materials and method for making
US9375169B2 (en) 2009-01-30 2016-06-28 Sanofi-Aventis Deutschland Gmbh Cam drive for managing disposable penetrating member actions with a single motor and motor and control system
ES2552337T3 (es) 2009-03-03 2015-11-27 Grifols Therapeutics Inc. Procedimientos para la preparación de plasminógeno
JP5836807B2 (ja) 2009-03-05 2015-12-24 アッヴィ・インコーポレイテッド Ｉｌ−１７結合タンパク質
EP2233925A1 (de) 2009-03-26 2010-09-29 Corning Inc. Immobilisierungsverfahren für Protein mit niedrigem isoelektrischem Punkt
JP4922341B2 (ja) * 2009-05-14 2012-04-25 シャープ株式会社 標的認識分子および標的認識分子を固定化する方法
EP2281632B1 (de) * 2009-07-02 2013-11-13 Amic AB Kapillare Testvorrichtung und deren Herstellung
WO2011057131A1 (en) 2009-11-09 2011-05-12 Spotlight Technology Partners Llc Polysaccharide based hydrogels
JP2013509963A (ja) 2009-11-09 2013-03-21 スポットライト テクノロジー パートナーズ エルエルシー 断片化ヒドロゲル
EP2507619B1 (de) 2009-11-30 2018-04-04 GE Healthcare Bio-Sciences AB Verfahren und system zur bindungsverhaltensanalyse
DK2507618T3 (en) 2009-11-30 2015-07-27 Ge Healthcare Bio Sciences Ab Method and system for interaction analysis
US8841137B2 (en) * 2010-02-25 2014-09-23 University Of Rochester Hybrid target analyte responsive polymer sensor with optical amplification
EP2362220A1 (de) 2010-02-25 2011-08-31 Corning Incorporated Affinitätshydrogel und etikettenunabhängige Detektionsverfahren dafür
US20110229921A1 (en) * 2010-03-18 2011-09-22 Abbott Laboratories METHODS OF ASSAYING URINARY NEUTROPHIL GELATINASE-ASSOCIATED LIPOCALIN (uNGAL) IN THE PROGNOSIS OF CADAVERIC KIDNEY TRANSPLANT FUNCTION IN A PATIENT, INCLUDING A PATIENT DIAGNOSED WITH DELAYED GRAFT FUNCTION (DGF), A METHOD OF ASSAYING uNGAL IN THE ASSESSMENT OF RISK OF DGF IN A PATIENT DIAGNOSED WITH EARLY GRAFT FUNCTION (EGF), AND RELATED KITS
US8965476B2 (en) 2010-04-16 2015-02-24 Sanofi-Aventis Deutschland Gmbh Tissue penetration device
EP3508854A1 (de) 2010-04-27 2019-07-10 The Regents of The University of California Krebsbiomarker und verfahren zur verwendung davon
TWI615405B (zh) 2010-05-14 2018-02-21 艾伯維有限公司 Ｉｌ-１結合蛋白
US20130078148A1 (en) * 2010-06-07 2013-03-28 Konica Minolta Holdings, Inc. Near field-enhanced fluorescence sensor chip
US9551714B2 (en) 2010-06-25 2017-01-24 Abbott Laboratories Materials and methods for assay of anti-hepatitis C virus (HCV) antibodies
US20120009196A1 (en) 2010-07-08 2012-01-12 Abbott Laboratories Monoclonal antibodies against hepatitis c virus core protein
UY33492A (es) 2010-07-09 2012-01-31 Abbott Lab Inmunoglobulinas con dominio variable dual y usos de las mismas
CA2807014A1 (en) 2010-08-03 2012-02-09 Abbvie Inc. Dual variable domain immunoglobulins and uses thereof
WO2012051519A2 (en) 2010-10-14 2012-04-19 The Johns Hopkins University Biomarkers of brain injury
US20120115244A1 (en) 2010-11-09 2012-05-10 Abbott Laboratories Materials and methods for immunoassay of pterins
TW201249865A (en) 2010-12-21 2012-12-16 Abbott Lab Dual variable domain immunoglobulins and uses thereof
JP5772612B2 (ja) * 2011-01-27 2015-09-02 コニカミノルタ株式会社 表面プラズモン励起増強蛍光分光法を利用する蛍光測定装置用センサチップを用いたアッセイ方法、およびアッセイ用キット
BR112013023722A2 (pt) 2011-03-15 2016-11-22 Univ Utah Res Found métodos para prever o risco de um indivíduo ter ou desenvolver uma coença, e para diagnosticar um indivíduo com uma doença, kit, modelo de animal não humano, e, sistema para identificar lóbulos coriocapilares aberrantes
EP2707389B1 (de) 2011-05-12 2019-10-30 The Johns Hopkins University Testreagenzien für eine neurogranin-diagnosekit
RU2014121043A (ru) 2011-10-24 2015-12-10 Эббви Инк. Биспецифические иммуносвязывающие средства, направленные против tnf и il-17
US8999331B2 (en) 2011-10-24 2015-04-07 Abbvie Inc. Immunobinders directed against sclerostin
DE102011057021A1 (de) * 2011-12-23 2013-06-27 Forschungszentrum Jülich GmbH Verfahren zur selektiven Quantifizierung von A-Beta-Aggregaten
US8993248B2 (en) 2011-12-31 2015-03-31 Abbott Laboratories Truncated human vitamin D binding protein and mutation and fusion thereof and related materials and methods of use
US20150010914A1 (en) 2012-01-20 2015-01-08 Adelaide Research & Innovation Pty Ltd. Biomarkers for gastric cancer and uses thereof
WO2013186672A2 (en) 2012-06-10 2013-12-19 Bio-Rad Laboratories Inc. Optical detection system for liquid samples
UY34905A (es) 2012-07-12 2014-01-31 Abbvie Inc Proteínas de unión a il-1
WO2014028907A1 (en) 2012-08-16 2014-02-20 The Trustees Of Columbia University In The City Of New York Diagnostic markers of indolent prostate cancer
AU2013202668B2 (en) 2012-12-24 2014-12-18 Adelaide Research & Innovation Pty Ltd Inhibition of cancer growth and metastasis
RU2527699C1 (ru) 2013-02-20 2014-09-10 федеральное государственное автономное образовательное учреждение высшего профессионального образования "Московский физико-технический институт (государственный университет) Биологический сенсор и способ создания биологического сенсора
MX2015012825A (es) 2013-03-14 2016-06-10 Abbott Lab Anticuerpos monoclonales del dominio de union de lipido del núcleo del virus de la hepatitis c vhc.
CA2906421C (en) 2013-03-14 2022-08-16 George J. Dawson Hcv antigen-antibody combination assay and methods and compositions for use therein
US9790478B2 (en) 2013-03-14 2017-10-17 Abbott Laboratories HCV NS3 recombinant antigens and mutants thereof for improved antibody detection
US9005901B2 (en) 2013-03-15 2015-04-14 Abbott Laboratories Assay with internal calibration
US9157910B2 (en) 2013-03-15 2015-10-13 Abbott Laboratories Assay with increased dynamic range
US20160109455A1 (en) 2013-05-10 2016-04-21 Vermillion, Inc. Compositions for ovarian cancer assessment having improved specificty
WO2015009907A1 (en) 2013-07-17 2015-01-22 The Johns Hopkins University A multi-protein biomarker assay for brain injury detection and outcome
CN105849529A (zh) 2013-11-19 2016-08-10 通用电气健康护理生物科学股份公司 用快速分离测定相互作用动力学的方法
EP3100048B1 (de) 2014-01-29 2021-05-05 Cytiva Sweden AB Verfahren und system zur interaktionsanalyse
WO2015197500A1 (en) 2014-06-24 2015-12-30 Ge Healthcare Bio-Sciences Ab Normalization of mass transport properties on optical sensor surfaces
JP2017521654A (ja) 2014-06-27 2017-08-03 アボット・ラボラトリーズＡｂｂｏｔｔ Ｌａｂｏｒａｔｏｒｉｅｓ ヒトペギウイルス２（ＨＰｇＶ−２）を検出するための組成物および方法
US10222386B2 (en) 2014-09-19 2019-03-05 The Johns Hopkins University Biomarkers of congnitive dysfunction
ES2828713T3 (es) 2014-10-29 2021-05-27 Abbott Lab Ensayos de detección de anticuerpos anti-VHC objeto usando péptidos de captura NS3
US11255852B2 (en) 2014-10-30 2022-02-22 Cytiva Sweden Ab Method to determine solvent correction curves
US11543411B2 (en) 2014-12-05 2023-01-03 Prelude Corporation DCIS recurrence and invasive breast cancer
BR112017015636A2 (pt) 2015-01-20 2018-03-13 Basf Coatings Gmbh processo para produção de laminados orgânico-inorgânicos flexíveis.
EP3259594A4 (de) 2015-02-20 2018-12-26 The Johns Hopkins University Biomarker für myokardläsion
GB2556004A (en) 2015-07-10 2018-05-16 Univ West Virginia Markers of stroke and stroke severity
DE102015115359B4 (de) 2015-09-11 2023-07-27 Bpc Arnold Gmbh Biopharma Consulting Biosensorchip
US20190000831A1 (en) 2015-12-11 2019-01-03 The General Hospital Corporation Compositions and methods for treating drug-tolerant glioblastoma
GB201709503D0 (en) * 2017-06-15 2017-08-02 Method and device for assay improvement
MA51647A (fr) 2017-08-16 2020-06-24 Medimmune Llc Compositions et méthodes pour le traitement de la dermatite atopique et la sélection du traitement
CN112272775A (zh) 2018-06-04 2021-01-26 雅芳产品公司 用于鉴定和治疗衰老皮肤和皮肤病症的蛋白生物标志物
AU2019339508A1 (en) 2018-09-14 2021-04-15 Prelude Corporation Method of selection for treatment of subjects at risk of invasive breast cancer
CA3136161A1 (en) * 2019-04-16 2020-10-22 Laboratory Corporation Of America Holdings Methods and systems for detecting antibodies by surface plasmon resonance
GB201917630D0 (en) 2019-12-03 2020-01-15 Ge Healthcare Bio Sciences Ab Method for determination of aggregates
WO2023122723A1 (en) 2021-12-23 2023-06-29 The Broad Institute, Inc. Panels and methods for diagnosing and treating lung cancer
WO2024041955A2 (en) 2022-08-25 2024-02-29 Cytiva Sweden Ab Sensor surface-based sample analysis

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3912614A (en) * 1972-01-10 1975-10-14 Int Biophysics Corp Sensor
US4330440A (en) * 1977-02-08 1982-05-18 Development Finance Corporation Of New Zealand Activated matrix and method of activation
US4287300A (en) * 1979-07-26 1981-09-01 Syva Company Charge effects in enzyme immunoassays
EP0101724A1 (de) * 1982-02-23 1984-03-07 Ventrex Laboratories Inc. Mehrzweckige träger für immunologische und biologische verwendung
CA1237645A (en) * 1982-12-21 1988-06-07 John H. Fisher Assay technique
GB8509491D0 (en) * 1985-04-12 1985-05-15 Plessey Co Plc Optic waveguide biosensors
GB8509492D0 (en) * 1985-04-12 1985-05-15 Plessey Co Plc Optical assay
GB8530715D0 (en) * 1985-12-13 1986-01-22 Unilever Plc Microchemical testing
EP0230768B1 (de) * 1985-12-20 1992-03-18 Syntex (U.S.A.) Inc. Teilchentrennungsverfahren
US4829009A (en) * 1986-02-21 1989-05-09 The Regents Of The University Of California Noise controlled immunoassays
JP2591750B2 (ja) * 1986-06-26 1997-03-19 オ−ソ・ダイアグノステイツク・システムズ・インコ−ポレ−テツド 免疫分析システム
GB8618133D0 (en) * 1986-07-24 1986-09-03 Pa Consulting Services Biosensors
IL85137A (en) * 1987-01-21 1992-02-16 Ares Serono Res & Dev Ltd Method of assaying for a ligand using surface plasmon resonance effect
CA1321488C (en) * 1987-08-22 1993-08-24 Martin Francis Finlan Biological sensors
US4842783A (en) * 1987-09-03 1989-06-27 Cordis Corporation Method of producing fiber optic chemical sensors incorporating photocrosslinked polymer gels
GB2217447A (en) * 1988-04-21 1989-10-25 Atomic Energy Authority Uk Bonding to metal surfaces
SE462454B (sv) * 1988-11-10 1990-06-25 Pharmacia Ab Maetyta foer anvaendning i biosensorer
CA1341592C (en) * 1989-07-07 2009-04-14 Abbott Laboratories Ion capture reagents and methods for performing binding assays

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10126341A1 (de) * 2001-05-30 2002-12-12 Siemens Ag Elektrochemischer DNA-Sensor, Verfahren zur Herstellung und Betrieb eines solchen DNA-Sensors
DE10319572A1 (de) * 2003-04-30 2004-11-25 Kist-Europe Forschungsgesellschaft Mbh Verfahren zur Bestimmung der Konzentration eines Analyten

Also Published As

Publication number Publication date
DE68926255D1 (de) 1996-05-15
SE8804073L (sv) 1990-05-11
US5242828A (en) 1993-09-07
EP0589867A1 (de) 1994-04-06
JPH04501605A (ja) 1992-03-19
EP0589867B1 (de) 1996-04-10
JP2815120B2 (ja) 1998-10-27
US5436161A (en) 1995-07-25
WO1990005303A1 (en) 1990-05-17
SE8804073D0 (sv) 1988-11-10
ATE136651T1 (de) 1996-04-15
SE462454B (sv) 1990-06-25

Similar Documents

Publication Publication Date Title
ATE136651T1 (de) Fühleroberflächen, fähig zur selektiven biomolekularen interaktionen zur verwendung in biosensorsystemen
DE3379659D1 (en) Preactivated surfaces of synthetic materials for immobilizing organochemical and biological substances, process for preparing them and their use
ATE83325T1 (de) Festphaseanalytische vorrichtung und verfahren zu ihrer verwendung.
ATE236656T1 (de) Eingeschränktes multifunktionelles reagens zur oberflächenmodifikation
GB8618133D0 (en) Biosensors
DE69113872D1 (de) Biologisch aktive Reagenzien aus Carboxylgruppenhaltigen Polymerisaten, analytisches Element und Verfahren zur Verwendung.
DE3380697D1 (en) Monoclonal antibody
GB2026692B (en) Methods and reagent combinations for determing a substance in a biological fluid which fluid contains an intereering materials
EP1002066A4 (de) Zusammensetzung und verfahren zur regulierung der adhäsion von zellen und biomolekülen an hydrophobe oberflächen
ES8303463A1 (es) Un procedimiento para la preparacion de un material soporte de particulas silanadas inorganicas fasiestacionaria orga- nica.
ATE414171T1 (de) Verfahren zur immobilisierung von oligonukleotiden auf festem trägermaterial
ATE67598T1 (de) Mit antigenen oder antikoerpern beschichteter traeger.
AU643454B2 (en) Method for measuring an immunologically active material and apparatus suitable for practicing said method
DE68901233D1 (de) Material zur fixierung biologischer substanzen und seine verwendung, insbesondere als traeger fuer die affinitaetschromatographie.
DE3683101D1 (de) Mit ueberzuegen versehene formkoerper zur bindung von bioaffinen substanzen.
ES8606498A1 (es) Procedimiento de ligacion de sustancias biologicamente importantes
ES2017153A6 (es) Portadores inmunorreactivos que tienen un nuevo recubrimiento intermedio biocompatible y su procedimiento de fabricacion.
JPS6488367A (en) Immobilized antibody
AU3435789A (en) Process for immobilizing or depositing molecules or substances on a support
Bergstrom et al. Matrix coating for sensing surfaces capable of selective biomolecular interactions, to be used in biosensor systems
ATE61404T1 (de) Verfahren zur herstellung von auf einem traeger immobilisierten hochaktiven biologischen verbindungen.
SE8903726D0 (sv) Fixierung von proteinen an festen traegern
IE780835L (en) Antibody immobilised in acrylamide copolymer matrix

Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8327 Change in the person/name/address of the patent owner

Owner name: GE HEALTHCARE BIO-SCIENCES AB, UPPSALA, SE