DE68926303D1 - Peptide und antikörper, die die integrin-ligandbindung inhibieren - Google Patents

Peptide und antikörper, die die integrin-ligandbindung inhibieren

Info

Publication number
DE68926303D1
DE68926303D1 DE68926303T DE68926303T DE68926303D1 DE 68926303 D1 DE68926303 D1 DE 68926303D1 DE 68926303 T DE68926303 T DE 68926303T DE 68926303 T DE68926303 T DE 68926303T DE 68926303 D1 DE68926303 D1 DE 68926303D1
Authority
DE
Germany
Prior art keywords
antibodies
integrine
ligandbinding
peptides
inhibit
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE68926303T
Other languages
English (en)
Other versions
DE68926303T2 (de
Inventor
Edward Plow
Souza Stanley D
Mark Ginsberg
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Scripps Research Institute
Original Assignee
Scripps Research Institute
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US07/252,674 external-priority patent/US5149780A/en
Application filed by Scripps Research Institute filed Critical Scripps Research Institute
Application granted granted Critical
Publication of DE68926303D1 publication Critical patent/DE68926303D1/de
Publication of DE68926303T2 publication Critical patent/DE68926303T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70546—Integrin superfamily
    • C07K14/70557—Integrin beta3-subunit-containing molecules, e.g. CD41, CD51, CD61
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2839—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the integrin superfamily
    • C07K16/2848—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the integrin superfamily against integrin beta3-subunit-containing molecules, e.g. CD41, CD51, CD61
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
DE68926303T 1988-10-03 1989-10-03 Peptide und antikörper, die die integrin-ligandbindung inhibieren Expired - Fee Related DE68926303T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US07/252,674 US5149780A (en) 1988-10-03 1988-10-03 Peptides and antibodies that inhibit integrin-ligand binding
US07/415,025 US5204445A (en) 1988-10-03 1989-10-02 Peptides and antibodies that inhibit integrin-ligand binding
PCT/US1989/004371 WO1990003983A1 (en) 1988-10-03 1989-10-03 Peptides and antibodies that inhibit integrin-ligand binding

Publications (2)

Publication Number Publication Date
DE68926303D1 true DE68926303D1 (de) 1996-05-23
DE68926303T2 DE68926303T2 (de) 1996-11-21

Family

ID=26942544

Family Applications (1)

Application Number Title Priority Date Filing Date
DE68926303T Expired - Fee Related DE68926303T2 (de) 1988-10-03 1989-10-03 Peptide und antikörper, die die integrin-ligandbindung inhibieren

Country Status (10)

Country Link
US (1) US5204445A (de)
EP (1) EP0436660B1 (de)
AT (1) ATE136908T1 (de)
AU (1) AU4427389A (de)
CA (1) CA2000048A1 (de)
DE (1) DE68926303T2 (de)
ES (1) ES2024728A6 (de)
GR (1) GR1001291B (de)
PT (1) PT91888A (de)
WO (1) WO1990003983A1 (de)

Families Citing this family (48)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3048632B2 (ja) * 1989-06-02 2000-06-05 ザ ジョーンズ ホプキンズ ユニヴァーシティ スクール オブ メディスン 白血球付着レセプターβ鎖に対するモノクローナル抗体と、この抗体の製造方法と、その応用
GB8914020D0 (en) † 1989-06-19 1989-08-09 Antisoma Ltd Synthetic peptides for use in thrombus detection
US6521594B1 (en) 1990-04-06 2003-02-18 La Jolla Cancer Research Foundation Method and composition for treating thrombosis
US5612311A (en) 1990-04-06 1997-03-18 La Jolla Cancer Research Foundation Method and composition for treating thrombosis
US5780303A (en) * 1990-04-06 1998-07-14 La Jolla Cancer Research Foundation Method and composition for treating thrombosis
US5672585A (en) * 1990-04-06 1997-09-30 La Jolla Cancer Research Foundation Method and composition for treating thrombosis
CA2090427A1 (en) * 1990-08-27 1992-02-28 Cetus Oncology Corporation Cd18 peptide medicaments for the treatment of disease
DE69228062D1 (de) * 1991-05-03 1999-02-11 Univ Rockefeller Endothelzell-Ligand für den Leukocyten CR3 erkennender Antikörper
AU2254792A (en) * 1991-07-01 1993-02-11 Blood Center Of Southeastern Wisconsin, The Pen polymorphism of human platelet membrane glycoprotein iiia and diagnostic and therapeutic application thereof
US5962643A (en) 1991-07-11 1999-10-05 The Regents Of The University Of California Integrin β subunit and uses thereof
CA2109398A1 (en) * 1992-10-30 1994-05-01 Alejandro A. Aruffo Extracellular matrix receptor ligands that modulate leukocyte function
AU698406B2 (en) * 1994-04-19 1998-10-29 University Of Kansas, The ICAM-1/LFA-1 short-chain peptides and method of using same
US6465253B1 (en) * 1994-09-08 2002-10-15 Genvec, Inc. Vectors and methods for gene transfer to cells
US5559099A (en) * 1994-09-08 1996-09-24 Genvec, Inc. Penton base protein and methods of using same
US5846782A (en) * 1995-11-28 1998-12-08 Genvec, Inc. Targeting adenovirus with use of constrained peptide motifs
US6127525A (en) * 1995-02-21 2000-10-03 Cornell Research Foundation, Inc. Chimeric adenoviral coat protein and methods of using same
US5770442A (en) * 1995-02-21 1998-06-23 Cornell Research Foundation, Inc. Chimeric adenoviral fiber protein and methods of using same
AU698317B2 (en) 1995-02-25 1998-10-29 Cancer Research Technology Limited Transgenic animals as model of psoriasis
ATE278794T1 (de) * 1995-06-15 2004-10-15 Crucell Holland Bv Verpackungssysteme für humane, menschliche adenoviren, zur verwendung in die gentherapie
US6783980B2 (en) * 1995-06-15 2004-08-31 Crucell Holland B.V. Packaging systems for human recombinant adenovirus to be used in gene therapy
US5817750A (en) * 1995-08-28 1998-10-06 La Jolla Cancer Research Foundation Structural mimics of RGD-binding sites
GB9600427D0 (en) * 1996-01-10 1996-03-13 Nycomed Imaging As Contrast media
AU716667B2 (en) 1996-01-10 2000-03-02 Nycomed Imaging As Contrast media
US6087332A (en) * 1997-12-23 2000-07-11 Galler; Lawrence Isaac Streptokinase derivatives with high affinity for activated platelets and methods of their production and use in thrombolytic therapy
US20030017138A1 (en) * 1998-07-08 2003-01-23 Menzo Havenga Chimeric adenoviruses
US20040043489A1 (en) * 1998-07-08 2004-03-04 Menzo Havenga Gene delivery vectors provided with a tissue tropism for dendritic cells and methods of use
US6929946B1 (en) * 1998-11-20 2005-08-16 Crucell Holland B.V. Gene delivery vectors provided with a tissue tropism for smooth muscle cells, and/or endothelial cells
US6913922B1 (en) * 1999-05-18 2005-07-05 Crucell Holland B.V. Serotype of adenovirus and uses thereof
US6492169B1 (en) 1999-05-18 2002-12-10 Crucell Holland, B.V. Complementing cell lines
US20050232900A1 (en) * 1999-05-18 2005-10-20 Crucell Holland B.V. Serotype of adenovirus and uses thereof
US7129052B1 (en) 2000-07-12 2006-10-31 The United States Of America As Represented By The Department Of Health And Human Services Peptides and their utility in modulation of behavior of cells expressing α3β1 integrins
AU6090200A (en) * 1999-07-15 2001-02-05 Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services, The Peptides and their utility in modulation of behavior of cells expressing alpha3beta1 integrins
EP1157999A1 (de) * 2000-05-24 2001-11-28 Introgene B.V. Verfahren und Mitteln zur Verbesserung der Haut-Transplantation mittels Genabgabe-Vehikel mit Tropismus für primären Fibroblasten, sowie andere Verwendungsmöglichkeiten für diesen
EP1322774A2 (de) * 2000-09-20 2003-07-02 Crucell Holland B.V. Transduktion von dendritischen zellen durch verwendung der adenovirenvektoren
US7235233B2 (en) * 2000-09-26 2007-06-26 Crucell Holland B.V. Serotype 5 adenoviral vectors with chimeric fibers for gene delivery in skeletal muscle cells or myoblasts
WO2002070007A1 (en) * 2001-03-02 2002-09-12 Medimmune, Inc. Methods of preventing or treating inflammatory or autoimmune disorders by administering integrin alphav beta3 antagonists
US20040002060A1 (en) * 2002-01-24 2004-01-01 Novartis Ag Fiber shaft modifications for efficient targeting
AU2003217930A1 (en) * 2002-03-04 2003-09-22 Medimmune, Llc The prevention or treatment of cancer using integrin alphavbeta3 antagonists in combination with other agents
WO2003075741A2 (en) * 2002-03-04 2003-09-18 Medimmune, Inc. METHODS OF PREVENTING OR TREATING DISORDERS BY ADMINISTERING AN INTEGRIN αvβ3 ANTAGONIST IN COMBINATION WITH AN HMG-CoA REDUCTASE INHIBITOR OR A BISPHOSPHONATE
EP1499352A4 (de) * 2002-04-12 2006-10-11 Medimmune Inc Rekombinante anti-interleukin-9-antikörper
EA010828B1 (ru) * 2002-04-25 2008-12-30 Круселл Холланд Б.В. Рекомбинантный аденовирусный вектор и способы его получения и применения
WO2004066956A2 (en) * 2003-01-30 2004-08-12 Medimmune, Inc. Uses of integrin alphavbeta3 antagonists
US7354584B2 (en) 2003-04-11 2008-04-08 Medimmune, Inc. Recombinant IL-9 antibodies
US7351739B2 (en) * 2004-04-30 2008-04-01 Wellgen, Inc. Bioactive compounds and methods of uses thereof
CA2585717A1 (en) 2004-10-27 2006-05-04 Medimmune Inc. Modulation of antibody specificity by tailoring the affinity to cognate antigens
EP2851064A3 (de) 2006-07-11 2015-08-05 Roy C. Levitt Prävention und Therapie von Rhinosinusitis mit proinflammatorischen Zytokinhemmern
PT2068889T (pt) 2006-08-10 2020-01-30 Roy C Levitt Anakinra para uso no tratamento da síndrome da bronquiolite obliterante
CN102834412B (zh) * 2010-02-18 2016-01-20 加利福尼亚大学董事会 整合素αVβ8中和抗体

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0303692A4 (en) * 1987-02-26 1990-12-05 Dana Farber Cancer Institute Cloning of lfa-1
US5114842A (en) * 1987-07-08 1992-05-19 The Scripps Research Institute Peptides and antibodies that inhibit platelet adhesion

Also Published As

Publication number Publication date
GR1001291B (el) 1993-07-30
US5204445A (en) 1993-04-20
PT91888A (pt) 1990-04-30
GR890100632A (en) 1990-11-29
CA2000048A1 (en) 1990-04-03
ATE136908T1 (de) 1996-05-15
EP0436660A1 (de) 1991-07-17
EP0436660B1 (de) 1996-04-17
EP0436660A4 (en) 1992-02-12
DE68926303T2 (de) 1996-11-21
ES2024728A6 (es) 1992-03-01
WO1990003983A1 (en) 1990-04-19
AU4427389A (en) 1990-05-01

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee