DE68928754D1 - Kollagen-polymer-konjugate - Google Patents

Kollagen-polymer-konjugate

Info

Publication number
DE68928754D1
DE68928754D1 DE68928754T DE68928754T DE68928754D1 DE 68928754 D1 DE68928754 D1 DE 68928754D1 DE 68928754 T DE68928754 T DE 68928754T DE 68928754 T DE68928754 T DE 68928754T DE 68928754 D1 DE68928754 D1 DE 68928754D1
Authority
DE
Germany
Prior art keywords
collagen
type
conjugates
polymer conjugates
fibrillar
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE68928754T
Other languages
English (en)
Other versions
DE68928754T2 (de
Inventor
Woonza Rhee
Donald Wallace
Alan Michaels
Ramon Burns
Louis Fries
Frank Delustro
Hanne Bentz
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Angiodevice International GmbH
Original Assignee
Collagen Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Collagen Corp filed Critical Collagen Corp
Publication of DE68928754D1 publication Critical patent/DE68928754D1/de
Application granted granted Critical
Publication of DE68928754T2 publication Critical patent/DE68928754T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L89/00—Compositions of proteins; Compositions of derivatives thereof
    • C08L89/04—Products derived from waste materials, e.g. horn, hoof or hair
    • C08L89/06—Products derived from waste materials, e.g. horn, hoof or hair derived from leather or skin, e.g. gelatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
    • A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/61—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule the organic macromolecular compound being a polysaccharide or a derivative thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
    • A61K47/6435—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent the peptide or protein in the drug conjugate being a connective tissue peptide, e.g. collagen, fibronectin or gelatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/22—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
    • A61L15/225—Mixtures of macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
    • A61L24/04—Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials
    • A61L24/10—Polypeptides; Proteins
    • A61L24/102—Collagen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
    • A61L26/0009—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form containing macromolecular materials
    • A61L26/0028—Polypeptides; Proteins; Degradation products thereof
    • A61L26/0033—Collagen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/18—Macromolecular materials obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/20—Polysaccharides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/22—Polypeptides or derivatives thereof, e.g. degradation products
    • A61L27/24—Collagen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/26—Mixtures of macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/28—Materials for coating prostheses
    • A61L27/34—Macromolecular materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/40—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material
    • A61L27/44—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/54—Biologically active materials, e.g. therapeutic substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L29/00—Materials for catheters, medical tubing, cannulae, or endoscopes or for coating catheters
    • A61L29/04—Macromolecular materials
    • A61L29/043—Polysaccharides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L29/00—Materials for catheters, medical tubing, cannulae, or endoscopes or for coating catheters
    • A61L29/04—Macromolecular materials
    • A61L29/044—Proteins; Polypeptides; Degradation products thereof
    • A61L29/045—Collagen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L29/00—Materials for catheters, medical tubing, cannulae, or endoscopes or for coating catheters
    • A61L29/04—Macromolecular materials
    • A61L29/06—Macromolecular materials obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L29/00—Materials for catheters, medical tubing, cannulae, or endoscopes or for coating catheters
    • A61L29/14—Materials characterised by their function or physical properties, e.g. lubricating compositions
    • A61L29/16—Biologically active materials, e.g. therapeutic substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/04—Macromolecular materials
    • A61L31/041—Mixtures of macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/04—Macromolecular materials
    • A61L31/042—Polysaccharides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/04—Macromolecular materials
    • A61L31/043—Proteins; Polypeptides; Degradation products thereof
    • A61L31/044—Collagen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/08—Materials for coatings
    • A61L31/10—Macromolecular materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/12—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material
    • A61L31/125—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/495—Transforming growth factor [TGF]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/78—Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin, cold insoluble globulin [CIG]
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
    • C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
    • C08B37/0069—Chondroitin-4-sulfate, i.e. chondroitin sulfate A; Dermatan sulfate, i.e. chondroitin sulfate B or beta-heparin; Chondroitin-6-sulfate, i.e. chondroitin sulfate C; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
    • C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
    • C08B37/0072—Hyaluronic acid, i.e. HA or hyaluronan; Derivatives thereof, e.g. crosslinked hyaluronic acid (hylan) or hyaluronates
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08H—DERIVATIVES OF NATURAL MACROMOLECULAR COMPOUNDS
    • C08H1/00—Macromolecular products derived from proteins
    • C08H1/06—Macromolecular products derived from proteins derived from horn, hoofs, hair, skin or leather
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09J—ADHESIVES; NON-MECHANICAL ASPECTS OF ADHESIVE PROCESSES IN GENERAL; ADHESIVE PROCESSES NOT PROVIDED FOR ELSEWHERE; USE OF MATERIALS AS ADHESIVES
    • C09J189/00—Adhesives based on proteins; Adhesives based on derivatives thereof
    • C09J189/04—Products derived from waste materials, e.g. horn, hoof or hair
    • C09J189/06—Products derived from waste materials, e.g. horn, hoof or hair derived from leather or skin
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B1/00—Optical elements characterised by the material of which they are made; Optical coatings for optical elements
    • G02B1/04—Optical elements characterised by the material of which they are made; Optical coatings for optical elements made of organic materials, e.g. plastics
    • G02B1/041—Lenses
    • G02B1/043—Contact lenses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/04—Hollow or tubular parts of organs, e.g. bladders, tracheae, bronchi or bile ducts
    • A61F2/06—Blood vessels
    • A61F2/07—Stent-grafts
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2310/00—Prostheses classified in A61F2/28 or A61F2/30 - A61F2/44 being constructed from or coated with a particular material
    • A61F2310/00005—The prosthesis being constructed from a particular material
    • A61F2310/00365—Proteins; Polypeptides; Degradation products thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
    • A61L2300/252—Polypeptides, proteins, e.g. glycoproteins, lipoproteins, cytokines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/412—Tissue-regenerating or healing or proliferative agents
    • A61L2300/414—Growth factors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/426—Immunomodulating agents, i.e. cytokines, interleukins, interferons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/60—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a special physical form
    • A61L2300/62—Encapsulated active agents, e.g. emulsified droplets
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/80—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a special chemical form
    • A61L2300/802—Additives, excipients, e.g. cyclodextrins, fatty acids, surfactants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2430/00—Materials or treatment for tissue regeneration
    • A61L2430/16—Materials or treatment for tissue regeneration for reconstruction of eye parts, e.g. intraocular lens, cornea
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L2666/00—Composition of polymers characterized by a further compound in the blend, being organic macromolecular compounds, natural resins, waxes or and bituminous materials, non-macromolecular organic substances, inorganic substances or characterized by their function in the composition
    • C08L2666/02—Organic macromolecular compounds, natural resins, waxes or and bituminous materials
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S525/00—Synthetic resins or natural rubbers -- part of the class 520 series
    • Y10S525/937—Utility as body contact e.g. implant, contact lens or I.U.D.
DE68928754T 1988-11-21 1989-11-21 Kollagen-polymer-konjugate Expired - Fee Related DE68928754T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US27407188A 1988-11-21 1988-11-21
US07/433,441 US5162430A (en) 1988-11-21 1989-11-14 Collagen-polymer conjugates
PCT/US1989/005351 WO1990005755A1 (en) 1988-11-21 1989-11-21 Collagen-polymer conjugates

Publications (2)

Publication Number Publication Date
DE68928754D1 true DE68928754D1 (de) 1998-08-27
DE68928754T2 DE68928754T2 (de) 1999-01-14

Family

ID=26956586

Family Applications (1)

Application Number Title Priority Date Filing Date
DE68928754T Expired - Fee Related DE68928754T2 (de) 1988-11-21 1989-11-21 Kollagen-polymer-konjugate

Country Status (9)

Country Link
US (8) US5162430A (de)
EP (1) EP0444157B1 (de)
JP (1) JP2505312B2 (de)
AT (1) ATE168708T1 (de)
AU (1) AU638687B2 (de)
CA (1) CA2003538C (de)
DE (1) DE68928754T2 (de)
ES (1) ES2119743T3 (de)
WO (1) WO1990005755A1 (de)

Families Citing this family (786)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10237531A1 (de) * 2002-08-16 2004-02-26 Tutogen Medical Gmbh Implantat
US6150328A (en) * 1986-07-01 2000-11-21 Genetics Institute, Inc. BMP products
US5550187A (en) * 1988-11-21 1996-08-27 Collagen Corporation Method of preparing crosslinked biomaterial compositions for use in tissue augmentation
US5527856A (en) * 1988-11-21 1996-06-18 Collagen Corporation Method of preparing crosslinked biomaterial compositions for use in tissue augmentation
US5565519A (en) * 1988-11-21 1996-10-15 Collagen Corporation Clear, chemically modified collagen-synthetic polymer conjugates for ophthalmic applications
US5162430A (en) * 1988-11-21 1992-11-10 Collagen Corporation Collagen-polymer conjugates
US5306500A (en) * 1988-11-21 1994-04-26 Collagen Corporation Method of augmenting tissue with collagen-polymer conjugates
US5614587A (en) * 1988-11-21 1997-03-25 Collagen Corporation Collagen-based bioadhesive compositions
US5643464A (en) 1988-11-21 1997-07-01 Collagen Corporation Process for preparing a sterile, dry crosslinking agent
US5936035A (en) * 1988-11-21 1999-08-10 Cohesion Technologies, Inc. Biocompatible adhesive compositions
US5510418A (en) * 1988-11-21 1996-04-23 Collagen Corporation Glycosaminoglycan-synthetic polymer conjugates
US5800541A (en) * 1988-11-21 1998-09-01 Collagen Corporation Collagen-synthetic polymer matrices prepared using a multiple step reaction
US5475052A (en) * 1988-11-21 1995-12-12 Collagen Corporation Collagen-synthetic polymer matrices prepared using a multiple step reaction
US5006330A (en) * 1988-11-30 1991-04-09 The United States Of America As Represented By The Of The Department Of Health And Human Services Evaluative means for detecting inflammatory reactivity
ES2238070T3 (es) * 1989-04-21 2005-08-16 Amgen Inc. Receptor del tnf, proteina ligante del tnf y adn codante para estos.
US7264944B1 (en) * 1989-04-21 2007-09-04 Amgen Inc. TNF receptors, TNF binding proteins and DNAs coding for them
US6143866A (en) * 1989-07-18 2000-11-07 Amgen, Inc. Tumor necrosis factor (TNF) inhibitor and method for obtaining the same
IL95031A (en) 1989-07-18 2007-03-08 Amgen Inc A method of producing a recombinant human necrotic factor absorber
US5817075A (en) * 1989-08-14 1998-10-06 Photogenesis, Inc. Method for preparation and transplantation of planar implants and surgical instrument therefor
US6514238B1 (en) 1989-08-14 2003-02-04 Photogenesis, Inc. Method for preparation and transplantation of volute grafts and surgical instrument therefor
SG49267A1 (en) 1989-08-14 1998-05-18 Photogenesis Inc Surgical instrument and cell isolation and transplantation
US5422340A (en) * 1989-09-01 1995-06-06 Ammann; Arthur J. TGF-βformulation for inducing bone growth
US5125888A (en) * 1990-01-10 1992-06-30 University Of Virginia Alumni Patents Foundation Magnetic stereotactic system for treatment delivery
CA2036606A1 (en) * 1990-02-20 1991-08-21 Michael Colvin Coated intraocular lens and coatings therefor
US5201764A (en) * 1990-02-28 1993-04-13 Autogenesis Technologies, Inc. Biologically compatible collagenous reaction product and articles useful as medical implants produced therefrom
US6552170B1 (en) * 1990-04-06 2003-04-22 Amgen Inc. PEGylation reagents and compounds formed therewith
DE69132692T2 (de) * 1990-06-14 2002-07-04 Integra Lifesciences I Corp Wundverband und Katheterhalterung aus einem Polyurethan-Biopolymer Kompositmaterial
US5833665A (en) * 1990-06-14 1998-11-10 Integra Lifesciences I, Ltd. Polyurethane-biopolymer composite
US5269785A (en) * 1990-06-28 1993-12-14 Bonutti Peter M Apparatus and method for tissue removal
US5626863A (en) * 1992-02-28 1997-05-06 Board Of Regents, The University Of Texas System Photopolymerizable biodegradable hydrogels as tissue contacting materials and controlled-release carriers
US5206023A (en) * 1991-01-31 1993-04-27 Robert F. Shaw Method and compositions for the treatment and repair of defects or lesions in cartilage
CA2060223C (en) * 1991-02-12 1999-07-20 Clarence C. Lee Injectable medical lubricating fluid composition and method of use
AU1462392A (en) * 1991-02-22 1992-09-15 Amgen, Inc. Use of gm-csf and g-csf to promote accelerated wound healing
EP0531547B1 (de) * 1991-03-29 1999-06-02 Vascular Graft Research Center Co., Ltd. Künstliches blutgefäss aus komposit-material
WO1992020371A1 (en) 1991-05-10 1992-11-26 Celtrix Pharmaceuticals, Inc. Targeted delivery of bone growth factors
CA2071137A1 (en) * 1991-07-10 1993-01-11 Clarence C. Lee Composition and method for revitalizing scar tissue
US6503277B2 (en) * 1991-08-12 2003-01-07 Peter M. Bonutti Method of transplanting human body tissue
US5270300A (en) * 1991-09-06 1993-12-14 Robert Francis Shaw Methods and compositions for the treatment and repair of defects or lesions in cartilage or bone
US6515009B1 (en) 1991-09-27 2003-02-04 Neorx Corporation Therapeutic inhibitor of vascular smooth muscle cells
US5811447A (en) 1993-01-28 1998-09-22 Neorx Corporation Therapeutic inhibitor of vascular smooth muscle cells
JP3504263B2 (ja) 1991-11-04 2004-03-08 ジェネティックス・インスチチュート・リミテッド・ライアビリティ・カンパニー 組み換え型骨形態形成蛋白ヘテロダイマー、組成物および使用法
US20080139474A1 (en) * 1991-11-04 2008-06-12 David Israel Recombinant bone morphogenetic protein heterodimers, compositions and methods of use
IT1260468B (it) * 1992-01-29 1996-04-09 Metodo per mantenere l'attivita' di enzimi proteolitici modificati con polietilenglicole
US7060287B1 (en) * 1992-02-11 2006-06-13 Bioform Inc. Tissue augmentation material and method
US7968110B2 (en) * 1992-02-11 2011-06-28 Merz Aesthetics, Inc. Tissue augmentation material and method
ES2153378T3 (es) 1992-02-28 2001-03-01 Univ Texas Hidrogeles biodegradables fotopolimerizables como materiales de contacto de tejidos y portadores de descarga controlada.
US5480644A (en) * 1992-02-28 1996-01-02 Jsf Consultants Ltd. Use of injectable biomaterials for the repair and augmentation of the anal sphincters
EP0627927A1 (de) * 1992-02-28 1994-12-14 Jsf Consultants Ltd. Verwendung injizierbarer biomaterialien zur behandlung von hämorrhoiden
US6045791A (en) * 1992-03-06 2000-04-04 Photogenesis, Inc. Retinal pigment epithelium transplantation
US6350274B1 (en) 1992-05-11 2002-02-26 Regen Biologics, Inc. Soft tissue closure systems
US5326350A (en) * 1992-05-11 1994-07-05 Li Shu Tung Soft tissue closure systems
DK0642301T3 (da) * 1992-05-29 2003-06-23 Univ North Carolina Farmaceutisk acceptable fikserede, tørrede humane blodplader
AU677789B2 (en) * 1992-07-02 1997-05-08 Collagen Corporation Biocompatible polymer conjugates
US6592859B1 (en) * 1992-08-20 2003-07-15 Ethicon, Inc. Controlled expansion sphincter augmentation media
US5836313A (en) * 1993-02-08 1998-11-17 Massachusetts Institute Of Technology Methods for making composite hydrogels for corneal prostheses
US6576008B2 (en) * 1993-02-19 2003-06-10 Scimed Life Systems, Inc. Methods and device for inserting and withdrawing a two piece stent across a constricting anatomic structure
FR2701648B1 (fr) * 1993-02-19 1995-03-31 Marian Devonec Prothèse destinée au traitement d'une lumière ou voie naturelle, notamment prothèse endo-uréthrale.
CA2121192A1 (en) * 1993-04-21 1994-10-22 Kiminori Atsumi Collagen membranes
WO1994023740A1 (en) * 1993-04-22 1994-10-27 Celtrix Pharmaceuticals, Inc. Conjugates of growth factor and bone resorption inhibitor
US5876454A (en) * 1993-05-10 1999-03-02 Universite De Montreal Modified implant with bioactive conjugates on its surface for improved integration
US5449720A (en) * 1993-05-24 1995-09-12 Biotech Australia Pty Limited Amplification of the VB12 uptake system using polymers
US5548064A (en) * 1993-05-24 1996-08-20 Biotech Australia Pty Limited Vitamin B12 conjugates with EPO, analogues thereof and pharmaceutical compositions
DE69427908T2 (de) * 1993-05-31 2001-11-22 Kaken Pharma Co Ltd Eine gelpräparation aus vernetzter gelatine, die einen basischen wachstumsfaktor für fibroblasten enthält
US5531791A (en) * 1993-07-23 1996-07-02 Bioscience Consultants Composition for repair of defects in osseous tissues, method of making, and prosthesis
EP0637450A3 (de) * 1993-08-04 1995-04-05 Collagen Corp Verfahren und Zusammensetzung zur Wiederbelebung von Nerbgewebe.
JPH09501932A (ja) * 1993-08-26 1997-02-25 ジェネティックス・インスティテュート・インコーポレイテッド ヒト・骨形態形成蛋白を用いる神経再生
US6291206B1 (en) * 1993-09-17 2001-09-18 Genetics Institute, Inc. BMP receptor proteins
US5446090A (en) * 1993-11-12 1995-08-29 Shearwater Polymers, Inc. Isolatable, water soluble, and hydrolytically stable active sulfones of poly(ethylene glycol) and related polymers for modification of surfaces and molecules
JP3717930B2 (ja) * 1993-12-07 2005-11-16 ジェネティックス・インスチチュート・リミテッド・ライアビリティ・カンパニー Ｂｍｐ−１２、ｂｍｐ−１３およびそれらの腱誘導組成物
FR2715309B1 (fr) * 1994-01-24 1996-08-02 Imedex Composition adhésive, à usage chirurgical, à base de collagène modifié par coupure oxydative et non réticulé.
US5656605A (en) * 1994-01-26 1997-08-12 Institute Of Molecular Biology, Inc. Device to promote drug-induced nerve regeneration
CA2140053C (en) * 1994-02-09 2000-04-04 Joel S. Rosenblatt Collagen-based injectable drug delivery system and its use
US5763416A (en) * 1994-02-18 1998-06-09 The Regent Of The University Of Michigan Gene transfer into bone cells and tissues
US5962427A (en) * 1994-02-18 1999-10-05 The Regent Of The University Of Michigan In vivo gene transfer methods for wound healing
US6074840A (en) 1994-02-18 2000-06-13 The Regents Of The University Of Michigan Recombinant production of latent TGF-beta binding protein-3 (LTBP-3)
US5942496A (en) * 1994-02-18 1999-08-24 The Regent Of The University Of Michigan Methods and compositions for multiple gene transfer into bone cells
US20020193338A1 (en) * 1994-02-18 2002-12-19 Goldstein Steven A. In vivo gene transfer methods for wound healing
US6551618B2 (en) 1994-03-15 2003-04-22 University Of Birmingham Compositions and methods for delivery of agents for neuronal regeneration and survival
WO1995025482A1 (en) * 1994-03-22 1995-09-28 Organogenesis, Inc. Three-dimensional bioremodelable collagen fabrics
US20050245850A1 (en) * 1994-03-30 2005-11-03 Freyre Carlos V Method and apparatus for inhibiting the growth of and shrinking cancerous tumors
US6500112B1 (en) 1994-03-30 2002-12-31 Brava, Llc Vacuum dome with supporting rim and rim cushion
US6001123A (en) * 1994-04-01 1999-12-14 Gore Enterprise Holdings Inc. Folding self-expandable intravascular stent-graft
US6165210A (en) * 1994-04-01 2000-12-26 Gore Enterprise Holdings, Inc. Self-expandable helical intravascular stent and stent-graft
CA2187109A1 (en) * 1994-04-04 1995-10-12 Collagen Corporation Cell-gels
CA2188563C (en) 1994-04-29 2005-08-02 Andrew W. Buirge Stent with collagen
US5629384A (en) * 1994-05-17 1997-05-13 Consiglio Nazionale Delle Ricerche Polymers of N-acryloylmorpholine activated at one end and conjugates with bioactive materials and surfaces
US5616689A (en) * 1994-07-13 1997-04-01 Collagen Corporation Method of controlling structure stability of collagen fibers produced form solutions or dispersions treated with sodium hydroxide for infectious agent deactivation
USRE38827E1 (en) 1994-07-27 2005-10-11 3M Innovative Properties Company Adhesive sealant composition
US6713662B1 (en) * 1994-07-27 2004-03-30 Pharming Intellectual Property B.V. Production of collagen in the milk of transgenic mammals
US5583114A (en) 1994-07-27 1996-12-10 Minnesota Mining And Manufacturing Company Adhesive sealant composition
US6331188B1 (en) 1994-08-31 2001-12-18 Gore Enterprise Holdings, Inc. Exterior supported self-expanding stent-graft
US6015429A (en) * 1994-09-08 2000-01-18 Gore Enterprise Holdings, Inc. Procedures for introducing stents and stent-grafts
JP3699141B2 (ja) * 1994-09-24 2005-09-28 伸彦 由井 超分子構造の生体内分解性医薬高分子集合体及びその調製方法
AU1287895A (en) * 1994-10-03 1996-04-26 Otogen Corporation Differentially biodegradable biomedical implants
US5738846A (en) * 1994-11-10 1998-04-14 Enzon, Inc. Interferon polymer conjugates and process for preparing the same
EP0713707A1 (de) 1994-11-23 1996-05-29 Collagen Corporation Injizierbare, in Situ vernetzbare Kollagenszusammensetzung für die Weichgewebevermehrung
US5588960A (en) * 1994-12-01 1996-12-31 Vidamed, Inc. Transurethral needle delivery device with cystoscope and method for treatment of urinary incontinence
US5518732A (en) * 1995-02-14 1996-05-21 Chiron Vision, Inc. Bio-erodible ophthalmic shield
US20050186673A1 (en) * 1995-02-22 2005-08-25 Ed. Geistlich Soehne Ag Fuer Chemistrie Industrie Collagen carrier of therapeutic genetic material, and method
GB9503492D0 (en) 1995-02-22 1995-04-12 Ed Geistlich S Hne A G F R Che Chemical product
US5868728A (en) * 1995-02-28 1999-02-09 Photogenesis, Inc. Medical linear actuator for surgical delivery, manipulation, and extraction
US5580923A (en) * 1995-03-14 1996-12-03 Collagen Corporation Anti-adhesion films and compositions for medical use
US6962979B1 (en) * 1995-03-14 2005-11-08 Cohesion Technologies, Inc. Crosslinkable biomaterial compositions containing hydrophobic and hydrophilic crosslinking agents
CA2165728A1 (en) * 1995-03-14 1996-09-15 Woonza M. Rhee Use of hydrophobic crosslinking agents to prepare crosslinked biomaterial compositions
US5674290A (en) * 1995-04-05 1997-10-07 Li; Shu-Tung Water-stabilized biopolymeric implants
DE19514087A1 (de) * 1995-04-13 1996-10-17 Deutsches Krebsforsch Konjugat aus einem Wirkstoff, einem Polyether und ggfs. einem nicht als körperfremd angesehenen, nativen Protein
US5676967A (en) * 1995-04-18 1997-10-14 Brennen Medical, Inc. Mesh matrix wound dressing
US6099562A (en) 1996-06-13 2000-08-08 Schneider (Usa) Inc. Drug coating with topcoat
US20020091433A1 (en) * 1995-04-19 2002-07-11 Ni Ding Drug release coated stent
US6120536A (en) * 1995-04-19 2000-09-19 Schneider (Usa) Inc. Medical devices with long term non-thrombogenic coatings
US5837313A (en) * 1995-04-19 1998-11-17 Schneider (Usa) Inc Drug release stent coating process
US6083912A (en) * 1995-05-01 2000-07-04 Roger K. Khouri Method for soft tissue augmentation
US6214331B1 (en) 1995-06-06 2001-04-10 C. R. Bard, Inc. Process for the preparation of aqueous dispersions of particles of water-soluble polymers and the particles obtained
AU6257796A (en) * 1995-06-06 1996-12-24 University Of Nebraska Board Of Regents Composition and method for administration of bio-affecting c atalysts
US5672662A (en) * 1995-07-07 1997-09-30 Shearwater Polymers, Inc. Poly(ethylene glycol) and related polymers monosubstituted with propionic or butanoic acids and functional derivatives thereof for biotechnical applications
WO1997013461A1 (en) * 1995-10-11 1997-04-17 Fusion Medical Technologies, Inc. Device and method for sealing tissue
US5776193A (en) * 1995-10-16 1998-07-07 Orquest, Inc. Bone grafting matrix
US6902584B2 (en) 1995-10-16 2005-06-07 Depuy Spine, Inc. Bone grafting matrix
JPH09143093A (ja) * 1995-11-17 1997-06-03 Hoechst Japan Ltd 軟骨・骨誘導性修復用材料
CN1052915C (zh) * 1995-11-27 2000-05-31 中国医学科学院生物医学工程研究所 用于携载基因的蛋白质涂层医用载体及其制作方法
CA2164262A1 (en) * 1995-12-01 1997-06-02 Charles J. Doillon Biostable porous material comprising composite biopolymers
US6042605A (en) * 1995-12-14 2000-03-28 Gore Enterprose Holdings, Inc. Kink resistant stent-graft
JP2000503559A (ja) 1995-12-14 2000-03-28 ゴア エンタープライズ ホールディングス，インコーポレイティド ステント移植片を展開する装置並びに方法
US7883693B2 (en) * 1995-12-18 2011-02-08 Angiodevice International Gmbh Compositions and systems for forming crosslinked biomaterials and methods of preparation of use
ATE330644T1 (de) 1995-12-18 2006-07-15 Angiotech Biomaterials Corp Vernetzten polymerisatmassen und verfahren für ihre verwendung
US5752974A (en) * 1995-12-18 1998-05-19 Collagen Corporation Injectable or implantable biomaterials for filling or blocking lumens and voids of the body
US6833408B2 (en) 1995-12-18 2004-12-21 Cohesion Technologies, Inc. Methods for tissue repair using adhesive materials
US6458889B1 (en) 1995-12-18 2002-10-01 Cohesion Technologies, Inc. Compositions and systems for forming crosslinked biomaterials and associated methods of preparation and use
CA2197375C (en) * 1996-02-15 2003-05-06 Yasuhiro Okuda Artificial blood vessel
SE9601243D0 (sv) * 1996-03-29 1996-03-29 Hans Arne Hansson Promotion of regeneration of organized tissues
US6224913B1 (en) 1996-05-09 2001-05-01 The Trustees Of The University Of Pennsylvania Conditioning of bioactive glass surfaces in protein containing solutions
US6416774B1 (en) 1996-05-09 2002-07-09 The Trustees Of The University Of Pennsyvania Hollow bone mineral-like calcium phosphate particles
US5940807A (en) * 1996-05-24 1999-08-17 Purcell; Daniel S. Automated and independently accessible inventory information exchange system
US5718012A (en) * 1996-05-28 1998-02-17 Organogenesis, Inc. Method of strength enhancement of collagen constructs
US5916585A (en) * 1996-06-03 1999-06-29 Gore Enterprise Holdings, Inc. Materials and method for the immobilization of bioactive species onto biodegradable polymers
US5855615A (en) * 1996-06-07 1999-01-05 Menlo Care, Inc. Controller expansion sphincter augmentation media
US6143037A (en) * 1996-06-12 2000-11-07 The Regents Of The University Of Michigan Compositions and methods for coating medical devices
US5792478A (en) * 1996-07-08 1998-08-11 Advanced Uro Science Tissue injectable composition and method of use
US5852127A (en) * 1996-07-09 1998-12-22 Rensselner Polytechnic Institute Modification of porous and non-porous materials using self-assembled monolayers
TW555765B (en) * 1996-07-09 2003-10-01 Amgen Inc Low molecular weight soluble tumor necrosis factor type-I and type-II proteins
EP0821878B1 (de) * 1996-07-29 2002-01-09 Loders Croklaan B.V. Kollagenmischung
ES2169835T3 (es) * 1996-07-29 2002-07-16 Loders Croklaan Bv Mezcla de colagenos.
US5813411A (en) * 1996-08-20 1998-09-29 Menlo Care, Inc. Method of deforming tissue with a swollen hydrogel
US7049346B1 (en) 1996-08-20 2006-05-23 Menlo Care Div Of Ethicon, Inc. Swollen hydrogel for sphincter augmentation
US8716227B2 (en) 1996-08-23 2014-05-06 Cook Biotech Incorporated Graft prosthesis, materials and methods
JP5053470B2 (ja) * 1996-08-23 2012-10-17 クック バイオテク インコーポレイティド グラフト・プロテーゼとその材料及び方法
US6666892B2 (en) * 1996-08-23 2003-12-23 Cook Biotech Incorporated Multi-formed collagenous biomaterial medical device
US6066325A (en) * 1996-08-27 2000-05-23 Fusion Medical Technologies, Inc. Fragmented polymeric compositions and methods for their use
US7435425B2 (en) 2001-07-17 2008-10-14 Baxter International, Inc. Dry hemostatic compositions and methods for their preparation
US8303981B2 (en) 1996-08-27 2012-11-06 Baxter International Inc. Fragmented polymeric compositions and methods for their use
US8603511B2 (en) 1996-08-27 2013-12-10 Baxter International, Inc. Fragmented polymeric compositions and methods for their use
US5989269A (en) 1996-08-30 1999-11-23 Vts Holdings L.L.C. Method, instruments and kit for autologous transplantation
US6569172B2 (en) 1996-08-30 2003-05-27 Verigen Transplantation Service International (Vtsi) Method, instruments, and kit for autologous transplantation
US20090324721A1 (en) * 1996-09-23 2009-12-31 Jack Kennedy Hydrogels Suitable For Use In Polyp Removal
WO1998012274A1 (en) * 1996-09-23 1998-03-26 Chandrashekar Pathak Methods and devices for preparing protein concentrates
US8003705B2 (en) 1996-09-23 2011-08-23 Incept Llc Biocompatible hydrogels made with small molecule precursors
US7009034B2 (en) * 1996-09-23 2006-03-07 Incept, Llc Biocompatible crosslinked polymers
US5856308A (en) * 1996-09-27 1999-01-05 Haemacure Corporation Artificial collagen
US6072040A (en) * 1996-10-15 2000-06-06 Medical Analysis Systems, Inc. Stabilized conjugates of uncomplexed subunits of multimeric proteins
US6387700B1 (en) * 1996-11-04 2002-05-14 The Reagents Of The University Of Michigan Cationic peptides, Cys-Trp-(LYS)n, for gene delivery
US5980972A (en) * 1996-12-20 1999-11-09 Schneider (Usa) Inc Method of applying drug-release coatings
US6551350B1 (en) 1996-12-23 2003-04-22 Gore Enterprise Holdings, Inc. Kink resistant bifurcated prosthesis
US6352561B1 (en) 1996-12-23 2002-03-05 W. L. Gore & Associates Implant deployment apparatus
US8556983B2 (en) 2001-05-25 2013-10-15 Conformis, Inc. Patient-adapted and improved orthopedic implants, designs and related tools
US8545569B2 (en) 2001-05-25 2013-10-01 Conformis, Inc. Patient selectable knee arthroplasty devices
US8083745B2 (en) 2001-05-25 2011-12-27 Conformis, Inc. Surgical tools for arthroplasty
US8735773B2 (en) 2007-02-14 2014-05-27 Conformis, Inc. Implant device and method for manufacture
US7534263B2 (en) 2001-05-25 2009-05-19 Conformis, Inc. Surgical tools facilitating increased accuracy, speed and simplicity in performing joint arthroplasty
US8771365B2 (en) 2009-02-25 2014-07-08 Conformis, Inc. Patient-adapted and improved orthopedic implants, designs, and related tools
US9603711B2 (en) 2001-05-25 2017-03-28 Conformis, Inc. Patient-adapted and improved articular implants, designs and related guide tools
US7468075B2 (en) 2001-05-25 2008-12-23 Conformis, Inc. Methods and compositions for articular repair
US8480754B2 (en) 2001-05-25 2013-07-09 Conformis, Inc. Patient-adapted and improved articular implants, designs and related guide tools
US8882847B2 (en) 2001-05-25 2014-11-11 Conformis, Inc. Patient selectable knee joint arthroplasty devices
US20040133276A1 (en) 2002-10-07 2004-07-08 Imaging Therapeutics, Inc. Minimally invasive joint implant with 3-Dimensional geometry matching the articular surfaces
AU6019898A (en) 1997-01-09 1998-08-03 Cohesion Technologies, Inc. Devices for tissue repair and methods for preparation and use thereof
US5925061A (en) * 1997-01-13 1999-07-20 Gore Enterprise Holdings, Inc. Low profile vascular stent
CN1168495C (zh) * 1997-01-15 2004-09-29 凤凰药理学公司 被修饰的肿瘤坏死因子
WO1998047547A1 (en) 1997-04-22 1998-10-29 Washington Research Foundation Trap-coated bone grafts and prostheses
US6149581A (en) * 1997-06-12 2000-11-21 Klingenstein; Ralph James Device and method for access to the colon and small bowel of a patient
US7192984B2 (en) * 1997-06-17 2007-03-20 Fziomed, Inc. Compositions of polyacids and polyethers and methods for their use as dermal fillers
WO1999006563A1 (en) 1997-07-30 1999-02-11 Emory University Novel bone mineralization proteins, dna, vectors, expression systems
US7923250B2 (en) 1997-07-30 2011-04-12 Warsaw Orthopedic, Inc. Methods of expressing LIM mineralization protein in non-osseous cells
US6117979A (en) * 1997-08-18 2000-09-12 Medtronic, Inc. Process for making a bioprosthetic device and implants produced therefrom
US6166184A (en) * 1997-08-18 2000-12-26 Medtronic Inc. Process for making a bioprosthetic device
US6342250B1 (en) 1997-09-25 2002-01-29 Gel-Del Technologies, Inc. Drug delivery devices comprising biodegradable protein for the controlled release of pharmacologically active agents and method of making the drug delivery devices
GB2329840C (en) 1997-10-03 2007-10-05 Johnson & Johnson Medical Biopolymer sponge tubes
US8858981B2 (en) * 1997-10-10 2014-10-14 Ed. Geistlich Soehne Fuer Chemistrie Industrie Bone healing material comprising matrix carrying bone-forming cells
US20030180263A1 (en) * 2002-02-21 2003-09-25 Peter Geistlich Resorbable extracellular matrix for reconstruction of bone
US20050186283A1 (en) * 1997-10-10 2005-08-25 Ed. Geistlich Soehne Ag Fuer Chemistrie Industrie Collagen carrier of therapeutic genetic material, and method
US8668737B2 (en) 1997-10-10 2014-03-11 Senorx, Inc. Tissue marking implant
US7637948B2 (en) * 1997-10-10 2009-12-29 Senorx, Inc. Tissue marking implant
US9034315B2 (en) * 1997-10-10 2015-05-19 Ed. Geistlich Soehne Ag Fuer Chemische Industrie Cell-charged multi-layer collagen membrane
US6511468B1 (en) * 1997-10-17 2003-01-28 Micro Therapeutics, Inc. Device and method for controlling injection of liquid embolic composition
US6458095B1 (en) 1997-10-22 2002-10-01 3M Innovative Properties Company Dispenser for an adhesive tissue sealant having a housing with multiple cavities
FI974321A0 (fi) * 1997-11-25 1997-11-25 Jenny Ja Antti Wihurin Rahasto Multipel heparinglykosaminoglykan och en proteoglykan innehaollande dessa
JP5095049B2 (ja) 1998-03-06 2012-12-12 バイオスフィアー メディカル，インク． 組織バルキング、および胃食道逆流疾患、尿失禁、皮膚のしわの治療のための移植可能な粒子
US6660301B1 (en) * 1998-03-06 2003-12-09 Biosphere Medical, Inc. Injectable microspheres for dermal augmentation and tissue bulking
EP1061954B1 (de) * 1998-03-12 2004-06-09 Nektar Therapeutics Al, Corporation Polyethylenglycolderivate mit benachbarten reaktiven gruppen
US6161034A (en) * 1999-02-02 2000-12-12 Senorx, Inc. Methods and chemical preparations for time-limited marking of biopsy sites
MXPA00010110A (es) * 1998-04-17 2002-08-06 Angiogenix Inc Factores angiogenicos terapeuticos y metodos para su uso.
US6395253B2 (en) 1998-04-23 2002-05-28 The Regents Of The University Of Michigan Microspheres containing condensed polyanionic bioactive agents and methods for their production
US6428978B1 (en) 1998-05-08 2002-08-06 Cohesion Technologies, Inc. Methods for the production of gelatin and full-length triple helical collagen in recombinant cells
US6197934B1 (en) 1998-05-22 2001-03-06 Collagenesis, Inc. Compound delivery using rapidly dissolving collagen film
US20020022588A1 (en) * 1998-06-23 2002-02-21 James Wilkie Methods and compositions for sealing tissue leaks
WO2000002905A2 (en) 1998-07-13 2000-01-20 University Of Southern California Methods for accelerating bone and cartilage growth and repair
US6916783B2 (en) * 1998-07-13 2005-07-12 University Of Southern California Methods for accelerating bone and cartilage growth and repair
US20020015724A1 (en) * 1998-08-10 2002-02-07 Chunlin Yang Collagen type i and type iii hemostatic compositions for use as a vascular sealant and wound dressing
CA2339575A1 (en) * 1998-08-10 2000-02-24 James W. Polarek Collagen type i and type iii hemostatic compositions for use as a vascular sealant and wound dressing
US6605294B2 (en) * 1998-08-14 2003-08-12 Incept Llc Methods of using in situ hydration of hydrogel articles for sealing or augmentation of tissue or vessels
US6514534B1 (en) * 1998-08-14 2003-02-04 Incept Llc Methods for forming regional tissue adherent barriers and drug delivery systems
US7347850B2 (en) * 1998-08-14 2008-03-25 Incept Llc Adhesion barriers applicable by minimally invasive surgery and methods of use thereof
US6152943A (en) 1998-08-14 2000-11-28 Incept Llc Methods and apparatus for intraluminal deposition of hydrogels
AU771701B2 (en) 1998-08-14 2004-04-01 Genzyme Corporation Methods, instruments and materials for chondrocyte cell transplantation
US7239908B1 (en) 1998-09-14 2007-07-03 The Board Of Trustees Of The Leland Stanford Junior University Assessing the condition of a joint and devising treatment
JP2002532126A (ja) 1998-09-14 2002-10-02 スタンフォード ユニバーシティ 関節状態の評価及び損傷防止装置
US6630457B1 (en) 1998-09-18 2003-10-07 Orthogene Llc Functionalized derivatives of hyaluronic acid, formation of hydrogels in situ using same, and methods for making and using same
US7662409B2 (en) 1998-09-25 2010-02-16 Gel-Del Technologies, Inc. Protein matrix materials, devices and methods of making and using thereof
US20050147690A1 (en) * 1998-09-25 2005-07-07 Masters David B. Biocompatible protein particles, particle devices and methods thereof
US20030007991A1 (en) * 1998-09-25 2003-01-09 Masters David B. Devices including protein matrix materials and methods of making and using thereof
FR2784580B1 (fr) 1998-10-16 2004-06-25 Biosepra Inc Microspheres de polyvinyl-alcool et procedes de fabrication de celles-ci
US7067144B2 (en) * 1998-10-20 2006-06-27 Omeros Corporation Compositions and methods for systemic inhibition of cartilage degradation
US6660843B1 (en) * 1998-10-23 2003-12-09 Amgen Inc. Modified peptides as therapeutic agents
US6110484A (en) * 1998-11-24 2000-08-29 Cohesion Technologies, Inc. Collagen-polymer matrices with differential biodegradability
US8882850B2 (en) * 1998-12-01 2014-11-11 Cook Biotech Incorporated Multi-formed collagenous biomaterial medical device
CA2319447C (en) 1998-12-01 2010-01-26 Washington University Embolization device
US6478656B1 (en) 1998-12-01 2002-11-12 Brava, Llc Method and apparatus for expanding soft tissue with shape memory alloys
EP1137373A4 (de) 1998-12-04 2004-05-19 Chandrashekhar P Pathak Biokompatible, vernetzte polymere
US20080114092A1 (en) * 1998-12-04 2008-05-15 Incept Llc Adhesion barriers applicable by minimally invasive surgery and methods of use thereof
US6361551B1 (en) 1998-12-11 2002-03-26 C. R. Bard, Inc. Collagen hemostatic fibers
US6454787B1 (en) 1998-12-11 2002-09-24 C. R. Bard, Inc. Collagen hemostatic foam
US6356782B1 (en) 1998-12-24 2002-03-12 Vivant Medical, Inc. Subcutaneous cavity marking device and method
US9669113B1 (en) 1998-12-24 2017-06-06 Devicor Medical Products, Inc. Device and method for safe location and marking of a biopsy cavity
US6371904B1 (en) 1998-12-24 2002-04-16 Vivant Medical, Inc. Subcutaneous cavity marking device and method
US20020065546A1 (en) * 1998-12-31 2002-05-30 Machan Lindsay S. Stent grafts with bioactive coatings
US20050171594A1 (en) * 1998-12-31 2005-08-04 Angiotech International Ag Stent grafts with bioactive coatings
WO2000043050A1 (en) * 1999-01-22 2000-07-27 St. Jude Medical, Inc. Medical adhesives
US6727224B1 (en) * 1999-02-01 2004-04-27 Genetics Institute, Llc. Methods and compositions for healing and repair of articular cartilage
US6862470B2 (en) 1999-02-02 2005-03-01 Senorx, Inc. Cavity-filling biopsy site markers
US7983734B2 (en) 2003-05-23 2011-07-19 Senorx, Inc. Fibrous marker and intracorporeal delivery thereof
US9820824B2 (en) 1999-02-02 2017-11-21 Senorx, Inc. Deployment of polysaccharide markers for treating a site within a patent
US7651505B2 (en) * 2002-06-17 2010-01-26 Senorx, Inc. Plugged tip delivery for marker placement
US20090030309A1 (en) 2007-07-26 2009-01-29 Senorx, Inc. Deployment of polysaccharide markers
US6725083B1 (en) 1999-02-02 2004-04-20 Senorx, Inc. Tissue site markers for in VIVO imaging
US8361082B2 (en) 1999-02-02 2013-01-29 Senorx, Inc. Marker delivery device with releasable plug
US8498693B2 (en) 1999-02-02 2013-07-30 Senorx, Inc. Intracorporeal marker and marker delivery device
AU3856400A (en) * 1999-02-12 2000-08-29 Collagenesis, Inc. Injectable collagen-based system for delivery of cells or therapeutic agents
FR2790475B1 (fr) * 1999-03-02 2003-01-24 Flamel Tech Sa Peptides collageniques modifies par greffage de fonctions mercapto, l'un de leurs procedes d'obtention et leurs applications comme biomateriaux
CA2370330C (en) 1999-04-16 2009-01-20 Wm. Marsh Rice University Biodegradable poly(propylene fumarate) networks cross linked with poly(propylene fumarate)-diacrylate macromers
US6428576B1 (en) * 1999-04-16 2002-08-06 Endospine, Ltd. System for repairing inter-vertebral discs
US6312725B1 (en) 1999-04-16 2001-11-06 Cohesion Technologies, Inc. Rapid gelling biocompatible polymer composition
US6858229B1 (en) * 1999-04-26 2005-02-22 California Institute Of Technology In situ forming hydrogels
US7015198B1 (en) 1999-05-11 2006-03-21 Orentreich Foundation For The Advancement Of Science, Inc. Materials for soft tissue augmentation and methods of making and using same
US6575991B1 (en) 1999-06-17 2003-06-10 Inrad, Inc. Apparatus for the percutaneous marking of a lesion
US7169889B1 (en) * 1999-06-19 2007-01-30 Biocon Limited Insulin prodrugs hydrolyzable in vivo to yield peglylated insulin
US6770740B1 (en) 1999-07-13 2004-08-03 The Regents Of The University Of Michigan Crosslinked DNA condensate compositions and gene delivery methods
US6312421B1 (en) 1999-07-23 2001-11-06 Neurovasx, Inc. Aneurysm embolization material and device
US6162258A (en) * 1999-08-25 2000-12-19 Osteotech, Inc. Lyophilized monolithic bone implant and method for treating bone
DK1218437T3 (da) 1999-08-27 2009-10-19 Angiodevice Internat Gmbh Præparater, som danner interpenetrerende polymernetværk, til anvendelse som medicinske tætningsmidler med höj styrke
BR0013639A (pt) * 1999-08-31 2004-06-15 Univ Virginia Commonwealth Matriz extra celular, processo para a manufatura de uma matriz extracelular, processo para formar uma prótese vascular, implante muscular, matriz extracelular para suporte de músculo, processo de formação de um revestimento facial muscular e processo de sobreposição de camadas de céluas musculares em uma matriz extracelular
US6783546B2 (en) 1999-09-13 2004-08-31 Keraplast Technologies, Ltd. Implantable prosthetic or tissue expanding device
US6371984B1 (en) 1999-09-13 2002-04-16 Keraplast Technologies, Ltd. Implantable prosthetic or tissue expanding device
PT1223990E (pt) * 1999-10-15 2004-12-31 Fidia Advanced Biopolymers Srl Formulacoes de acido hialuronico para administracao de proteinas osteogenicas
EE04250B1 (et) * 1999-11-29 2004-02-16 Tartu Ülikool Biosensor ja selle valmistamise meetod
AU2136501A (en) * 1999-12-10 2001-06-18 Celator Technologies Inc. Lipid carrier compositions with protected surface reactive functions
US6623963B1 (en) 1999-12-20 2003-09-23 Verigen Ag Cellular matrix
US20030095993A1 (en) * 2000-01-28 2003-05-22 Hanne Bentz Gel-infused sponges for tissue repair and augmentation
DE60137489D1 (de) * 2000-02-03 2009-03-12 Tissuemed Ltd Gerät zum verschliessen einer chirurgischen punktionswunde
EP1274472A2 (de) 2000-03-20 2003-01-15 Biosphere Medical, Inc. Injizierbare und schwellfähige mikrokügelchen zur gewebeverstärkung
US6436424B1 (en) 2000-03-20 2002-08-20 Biosphere Medical, Inc. Injectable and swellable microspheres for dermal augmentation
US7338657B2 (en) * 2001-03-15 2008-03-04 Biosphere Medical, Inc. Injectable microspheres for tissue construction
WO2001072281A2 (en) * 2000-03-24 2001-10-04 Biosphere Medical Inc. Microspheres for active embolization
JP4074043B2 (ja) * 2000-03-27 2008-04-09 株式会社資生堂 皮膚基底膜形成促進剤、人工皮膚形成促進剤及び人工皮膚の製造方法
US6884778B2 (en) * 2000-04-14 2005-04-26 William Marsh Rice University Biocompatible macromers
US6776796B2 (en) 2000-05-12 2004-08-17 Cordis Corportation Antiinflammatory drug and delivery device
US20050002986A1 (en) * 2000-05-12 2005-01-06 Robert Falotico Drug/drug delivery systems for the prevention and treatment of vascular disease
US20040243097A1 (en) * 2000-05-12 2004-12-02 Robert Falotico Antiproliferative drug and delivery device
US8236048B2 (en) * 2000-05-12 2012-08-07 Cordis Corporation Drug/drug delivery systems for the prevention and treatment of vascular disease
SG98393A1 (en) 2000-05-19 2003-09-19 Inst Materials Research & Eng Injectable drug delivery systems with cyclodextrin-polymer based hydrogels
US7083644B1 (en) * 2000-05-24 2006-08-01 Scimed Life Systems, Inc. Implantable prostheses with improved mechanical and chemical properties
US6423332B1 (en) 2000-05-26 2002-07-23 Ethicon, Inc. Method and composition for deforming soft tissues
US20030032143A1 (en) * 2000-07-24 2003-02-13 Neff Thomas B. Collagen type I and type III compositions for use as an adhesive and sealant
EP1311657A2 (de) * 2000-08-21 2003-05-21 Rice University Gewebeaufbaugerüste zur förderung der produktion der matrixproteine
US7726319B1 (en) 2000-08-24 2010-06-01 Osteotech, Inc. Method for removal of water associated with bone while diminishing the dimensional changes associated with lyophilization
CA2425089A1 (en) 2000-09-14 2002-03-21 Philipp Lang Assessing condition of a joint and cartilage loss
WO2002022014A1 (en) 2000-09-14 2002-03-21 The Board Of Trustees Of The Leland Stanford Junior University Assessing the condition of a joint and devising treatment
CA2423061A1 (en) * 2000-09-25 2002-03-28 Cohesion Technologies, Inc. Resorbable anastomosis stents and plugs
US20050165428A1 (en) * 2000-09-25 2005-07-28 Franco Kenneth L. Absorable surgical structure
US7029486B2 (en) * 2000-09-26 2006-04-18 Microvention, Inc. Microcoil vaso-occlusive device with multi-axis secondary configuration
US6296607B1 (en) * 2000-10-20 2001-10-02 Praxis, Llc. In situ bulking device
US7261735B2 (en) 2001-05-07 2007-08-28 Cordis Corporation Local drug delivery devices and methods for maintaining the drug coatings thereon
US20020111590A1 (en) 2000-09-29 2002-08-15 Davila Luis A. Medical devices, drug coatings and methods for maintaining the drug coatings thereon
US20020051730A1 (en) * 2000-09-29 2002-05-02 Stanko Bodnar Coated medical devices and sterilization thereof
JP5100951B2 (ja) 2000-09-29 2012-12-19 コーディス・コーポレイション 被覆医用器具
ES2236314T3 (es) * 2000-10-23 2005-07-16 Tissuemed Limited Maatriz autoadhesiva hidratable para uso terapeutico topico.
ES2409758T3 (es) * 2000-11-20 2013-06-27 Senorx, Inc. Marcadores de sitios tisulares para formación de imagen in vivo
US20030082233A1 (en) * 2000-12-01 2003-05-01 Lyons Karen M. Method and composition for modulating bone growth
EP1346726A4 (de) * 2000-12-25 2004-09-15 Shiseido Co Ltd Parfumzusammenstellung die das sympathetische system stimulieren
US9080146B2 (en) 2001-01-11 2015-07-14 Celonova Biosciences, Inc. Substrates containing polyphosphazene as matrices and substrates containing polyphosphazene with a micro-structured surface
WO2002058541A2 (en) * 2001-01-23 2002-08-01 Abbeymoor Medical, Inc. Endourethral device & method
US7060675B2 (en) 2001-02-15 2006-06-13 Nobex Corporation Methods of treating diabetes mellitus
US6867183B2 (en) 2001-02-15 2005-03-15 Nobex Corporation Pharmaceutical compositions of insulin drug-oligomer conjugates and methods of treating diseases therewith
EP1423093A4 (de) * 2001-04-23 2005-11-30 Wisconsin Alumni Res Found Bifunktional modifizierte hydrogele
AU784394B2 (en) 2001-04-27 2006-03-23 Geistlich Pharma Ag Method and membrane for mucosa regeneration
US8182527B2 (en) * 2001-05-07 2012-05-22 Cordis Corporation Heparin barrier coating for controlled drug release
WO2013155501A1 (en) 2012-04-13 2013-10-17 Conformis, Inc. Patient adapted joint arthroplasty devices, surgical tools and methods of use
US8439926B2 (en) 2001-05-25 2013-05-14 Conformis, Inc. Patient selectable joint arthroplasty devices and surgical tools
WO2002096268A2 (en) 2001-05-25 2002-12-05 Imaging Therapeutics, Inc. Methods and compositions for articular resurfacing
US8951260B2 (en) 2001-05-25 2015-02-10 Conformis, Inc. Surgical cutting guide
NZ530045A (en) * 2001-06-01 2007-07-27 Wyeth Corp Compositions and methods for systemic administration of sequences encoding bone morphogenetic proteins
US6713452B2 (en) * 2001-06-04 2004-03-30 Nobex Corporation Mixtures of calcitonin drug-oligomer conjugates comprising polyalkylene glycol, uses thereof, and methods of making same
US6858580B2 (en) * 2001-06-04 2005-02-22 Nobex Corporation Mixtures of drug-oligomer conjugates comprising polyalkylene glycol, uses thereof, and methods of making same
US6835802B2 (en) * 2001-06-04 2004-12-28 Nobex Corporation Methods of synthesizing substantially monodispersed mixtures of polymers having polyethylene glycol moieties
US7713932B2 (en) 2001-06-04 2010-05-11 Biocon Limited Calcitonin drug-oligomer conjugates, and uses thereof
US6828305B2 (en) 2001-06-04 2004-12-07 Nobex Corporation Mixtures of growth hormone drug-oligomer conjugates comprising polyalkylene glycol, uses thereof, and methods of making same
US6828297B2 (en) 2001-06-04 2004-12-07 Nobex Corporation Mixtures of insulin drug-oligomer conjugates comprising polyalkylene glycol, uses thereof, and methods of making same
US20030003157A1 (en) * 2001-06-06 2003-01-02 University Of Medicine & Dentistry Of New Jersey Collagen compositions and methods for making and using the same
TWI267378B (en) * 2001-06-08 2006-12-01 Wyeth Corp Calcium phosphate delivery vehicles for osteoinductive proteins
WO2002100444A1 (en) * 2001-06-08 2002-12-19 Biosphere Medical Inc. Colloidal metal labelled microparticles, their production and use
US6702744B2 (en) 2001-06-20 2004-03-09 Advanced Cardiovascular Systems, Inc. Agents that stimulate therapeutic angiogenesis and techniques and devices that enable their delivery
US6994722B2 (en) 2001-07-03 2006-02-07 Scimed Life Systems, Inc. Implant having improved fixation to a body lumen and method for implanting the same
US20030014075A1 (en) * 2001-07-16 2003-01-16 Microvention, Inc. Methods, materials and apparatus for deterring or preventing endoleaks following endovascular graft implanation
US8252040B2 (en) 2001-07-20 2012-08-28 Microvention, Inc. Aneurysm treatment device and method of use
US8715312B2 (en) 2001-07-20 2014-05-06 Microvention, Inc. Aneurysm treatment device and method of use
US7572288B2 (en) 2001-07-20 2009-08-11 Microvention, Inc. Aneurysm treatment device and method of use
US7105182B2 (en) * 2001-07-25 2006-09-12 Szymaitis Dennis W Periodontal regeneration composition and method of using same
US7312192B2 (en) 2001-09-07 2007-12-25 Biocon Limited Insulin polypeptide-oligomer conjugates, proinsulin polypeptide-oligomer conjugates and methods of synthesizing same
US6770625B2 (en) * 2001-09-07 2004-08-03 Nobex Corporation Pharmaceutical compositions of calcitonin drug-oligomer conjugates and methods of treating diseases therewith
US7196059B2 (en) 2001-09-07 2007-03-27 Biocon Limited Pharmaceutical compositions of insulin drug-oligomer conjugates and methods of treating diseases therewith
US6913903B2 (en) 2001-09-07 2005-07-05 Nobex Corporation Methods of synthesizing insulin polypeptide-oligomer conjugates, and proinsulin polypeptide-oligomer conjugates and methods of synthesizing same
US7030082B2 (en) * 2001-09-07 2006-04-18 Nobex Corporation Pharmaceutical compositions of drug-oligomer conjugates and methods of treating disease therewith
US7166571B2 (en) 2001-09-07 2007-01-23 Biocon Limited Insulin polypeptide-oligomer conjugates, proinsulin polypeptide-oligomer conjugates and methods of synthesizing same
US7195640B2 (en) * 2001-09-25 2007-03-27 Cordis Corporation Coated medical devices for the treatment of vulnerable plaque
US7108701B2 (en) 2001-09-28 2006-09-19 Ethicon, Inc. Drug releasing anastomosis devices and methods for treating anastomotic sites
US20030065345A1 (en) * 2001-09-28 2003-04-03 Kevin Weadock Anastomosis devices and methods for treating anastomotic sites
CN100515504C (zh) * 2001-10-12 2009-07-22 美国英佛曼公司 涂层,涂布体及其制造方法
CA2464287C (en) 2001-10-23 2011-02-08 Tyco Healthcare Group Lp Surgical fasteners
US7629388B2 (en) * 2001-11-20 2009-12-08 William Marsh Rice University Synthesis and characterization of biodegradable cationic poly(propylene fumarate-co-ethylene glycol) copolymer hydrogels modified with agmatine for enhanced cell adhesion
CA2412012C (en) * 2001-11-20 2011-08-02 Ed. Geistlich Soehne Ag Fuer Chemische Industrie Resorbable extracellular matrix containing collagen i and collagen ii for reconstruction of cartilage
US8608661B1 (en) 2001-11-30 2013-12-17 Advanced Cardiovascular Systems, Inc. Method for intravascular delivery of a treatment agent beyond a blood vessel wall
US20030181371A1 (en) * 2001-12-28 2003-09-25 Angiotech Pharmaceuticals, Inc. Compositions and methods of using collajolie
EP1465933B1 (de) * 2002-01-16 2007-08-29 Biocompatibles UK Limited Polymerkonjugate
WO2003061626A1 (en) * 2002-01-18 2003-07-31 Control Delivery Systems, Inc. Polymeric gel system for the controlled delivery of codrugs
WO2003068053A2 (en) * 2002-02-14 2003-08-21 Photogenesis, Inc. Subretinal implantation device and surgical cannulas for use therewith
AU2003216379A1 (en) * 2002-02-22 2003-09-09 Control Delivery Systems, Inc. Method for treating otic disorders
US20030171773A1 (en) 2002-03-06 2003-09-11 Carrison Harold F. Methods for aneurysm repair
US20030203032A1 (en) * 2002-04-25 2003-10-30 Schultz Clyde L. Growth factor delivery system for the healing of wounds and the prevention of inflammation and disease
CA2483265A1 (en) * 2002-04-25 2003-11-06 Clyde L. Schultz Growth factor delivery system for the healing of wounds and the prevention of inflammation and disease
US8623393B2 (en) * 2002-04-29 2014-01-07 Gel-Del Technologies, Inc. Biomatrix structural containment and fixation systems and methods of use thereof
EP1519744A4 (de) * 2002-05-17 2007-10-03 Wyeth Corp Injizierbare feste hyaluronsäureträger zur zuführung von osteogenen proteinen
EP1364663A1 (de) * 2002-05-21 2003-11-26 Commonwealth Scientific And Industrial Research Organisation Okulare Vorrichtungen mit funktionalisierter Oberfläche mit adhäsiven Eigenschaften
AU2003236521A1 (en) * 2002-06-13 2003-12-31 Nobex Corporation Methods of reducing hypoglycemic episodes in the treatment of diabetes mellitus
US7361368B2 (en) * 2002-06-28 2008-04-22 Advanced Cardiovascular Systems, Inc. Device and method for combining a treatment agent and a gel
US20080226723A1 (en) * 2002-07-05 2008-09-18 Celonova Biosciences, Inc. Loadable Polymeric Particles for Therapeutic Use in Erectile Dysfunction and Methods of Preparing and Using the Same
EP1531757B1 (de) * 2002-07-19 2016-09-07 Omeros Corporation Biologisch abbaubare triblock-copolymere, syntheseverfahren daf r und hydrogele und daraus hergestellte biologische materialien
MXPA05002632A (es) 2002-09-09 2005-09-20 Nektar Therapeutics Al Corp Metodo para preparar derivados de polimeros solubles en agua que portan un acido carboxilico terminal.
JP5156890B2 (ja) * 2002-09-11 2013-03-06 独立行政法人物質・材料研究機構 高分子架橋体及びその製造方法
US7008763B2 (en) * 2002-09-23 2006-03-07 Cheung David T Method to treat collagenous connective tissue for implant remodeled by host cells into living tissue
US7407672B2 (en) * 2002-11-04 2008-08-05 National Heart Center Composition derived from biological materials and method of use and preparation
EP3075356B1 (de) 2002-11-07 2023-07-05 ConforMIS, Inc. Verfahren zur auswahl eines meniskusimplantats
US20060036158A1 (en) * 2003-11-17 2006-02-16 Inrad, Inc. Self-contained, self-piercing, side-expelling marking apparatus
ES2347239T3 (es) 2002-12-02 2010-10-27 Amgen Fremont Inc. Anticuerpos dirigidos al factor de necrosis tumoral y usos de los mismos.
CA2511486A1 (en) * 2002-12-30 2004-07-22 Angiotech International Ag Tissue reactive compounds and compositions and uses thereof
CA2511484A1 (en) * 2002-12-30 2004-07-22 Angiotech International Ag Silk-containing stent graft
EP1594459B1 (de) 2002-12-30 2010-02-17 Angiotech International Ag Wirkstofffreisetzung von schnell gelierender polymerzusammensetzung
US20080208160A9 (en) * 2003-01-10 2008-08-28 Mawad Michel E Microcatheter including swellable tip
US7079091B2 (en) * 2003-01-14 2006-07-18 Eastman Kodak Company Compensating for aging in OLED devices
GB0301014D0 (en) * 2003-01-16 2003-02-19 Biocompatibles Ltd Conjugation reactions
FR2850282B1 (fr) * 2003-01-27 2007-04-06 Jerome Asius Implant injectable a base de ceramique pour le comblement de rides, depressions cutanees et cicatrices, et sa preparation
JP4489761B2 (ja) 2003-03-14 2010-06-23 ザ トラスティーズ オブ コロンビア ユニヴァーシティ イン ザ シティ オブ ニューヨーク マイクロ流体無膜交換装置を有する血液ベースの治療のためのシステム及び方法
US20060076295A1 (en) 2004-03-15 2006-04-13 The Trustees Of Columbia University In The City Of New York Systems and methods of blood-based therapies having a microfluidic membraneless exchange device
EP1464345B1 (de) * 2003-04-03 2009-12-30 Dennis W. Szymaitis Zusammensetzung für die Wiederherstellung von Knochen und umliegendem Gewebe
JP2006523113A (ja) * 2003-04-04 2006-10-12 ティシュームド リミテッド 組織接着構成物
US20050074497A1 (en) * 2003-04-09 2005-04-07 Schultz Clyde L. Hydrogels used to deliver medicaments to the eye for the treatment of posterior segment diseases
US9216106B2 (en) 2003-04-09 2015-12-22 Directcontact Llc Device and method for the delivery of drugs for the treatment of posterior segment disease
US20050255144A1 (en) * 2003-04-09 2005-11-17 Directcontact Llc Methods and articles for the delivery of medicaments to the eye for the treatment of posterior segment diseases
US7273896B2 (en) 2003-04-10 2007-09-25 Angiotech Pharmaceuticals (Us), Inc. Compositions and methods of using a transient colorant
FR2861734B1 (fr) 2003-04-10 2006-04-14 Corneal Ind Reticulation de polysaccharides de faible et forte masse moleculaire; preparation d'hydrogels monophasiques injectables; polysaccharides et hydrogels obtenus
US8821473B2 (en) 2003-04-15 2014-09-02 Abbott Cardiovascular Systems Inc. Methods and compositions to treat myocardial conditions
US7641643B2 (en) 2003-04-15 2010-01-05 Abbott Cardiovascular Systems Inc. Methods and compositions to treat myocardial conditions
US8038991B1 (en) 2003-04-15 2011-10-18 Abbott Cardiovascular Systems Inc. High-viscosity hyaluronic acid compositions to treat myocardial conditions
US7877133B2 (en) 2003-05-23 2011-01-25 Senorx, Inc. Marker or filler forming fluid
US8834864B2 (en) 2003-06-05 2014-09-16 Baxter International Inc. Methods for repairing and regenerating human dura mater
US8465537B2 (en) * 2003-06-17 2013-06-18 Gel-Del Technologies, Inc. Encapsulated or coated stent systems
WO2005010080A1 (ja) * 2003-07-28 2005-02-03 Teijin Limited 温度応答性ハイドロゲル
US7927626B2 (en) * 2003-08-07 2011-04-19 Ethicon, Inc. Process of making flowable hemostatic compositions and devices containing such compositions
WO2005034852A2 (en) * 2003-08-26 2005-04-21 Gel-Del Technologies, Inc. Protein biomaterials and biocoacervates and methods of making and using thereof
JP5392981B2 (ja) * 2003-09-12 2014-01-22 ワイス・エルエルシー 骨形成蛋白の送達のための注入可能なリン酸カルシウム固体ロッドおよびペースト
US7309232B2 (en) * 2003-10-10 2007-12-18 Dentigenix Inc. Methods for treating dental conditions using tissue scaffolds
DE602004021022D1 (de) * 2003-10-28 2009-06-18 Medtronic Inc Verfahren zur herstellung von vernetzten materialien und bioprothetischen vorrichtungen
WO2005046746A2 (en) * 2003-11-10 2005-05-26 Angiotech International Ag Medical implants and fibrosis-inducing agents
AU2004289362A1 (en) * 2003-11-10 2005-05-26 Angiotech International Ag Intravascular devices and fibrosis-inducing agents
US20050273002A1 (en) * 2004-06-04 2005-12-08 Goosen Ryan L Multi-mode imaging marker
US20050208095A1 (en) * 2003-11-20 2005-09-22 Angiotech International Ag Polymer compositions and methods for their use
EP1691746B1 (de) * 2003-12-08 2015-05-27 Gel-Del Technologies, Inc. Mukoadhäsive arzneimittelabgabevorrichtungen und verfahren zu ihrer herstellung und verwendung
US20080109057A1 (en) * 2003-12-10 2008-05-08 Calabria Marie F Multiple point detacher system
US20070104752A1 (en) * 2003-12-10 2007-05-10 Lee Jeffrey A Aneurysm embolization material and device
US20050142161A1 (en) * 2003-12-30 2005-06-30 Freeman Lynetta J. Collagen matrix for soft tissue augmentation
US7608663B2 (en) * 2004-01-21 2009-10-27 Nektar Therapeutics Method of preparing propionic acid-terminated polymers
AU2005219043A1 (en) * 2004-03-02 2005-09-15 Exotech Bio Solutions Ltd. Biocompatible, biodegradable, water-absorbent hybrid material
EP1735022B1 (de) 2004-04-15 2009-07-08 Nexilis AG Osteogenes matrixkomposit, verfahren zu dessen herstellung sowie implantat und scaffold für das tissue engineering mit einer beschichtung aus einem osteogenen matrixkomposit
CN104174071A (zh) 2004-04-28 2014-12-03 安希奥设备国际有限责任公司 用于形成交联生物材料的组合物和系统及关联的制备方法与用途
US8293890B2 (en) * 2004-04-30 2012-10-23 Advanced Cardiovascular Systems, Inc. Hyaluronic acid based copolymers
EP1750769B1 (de) * 2004-05-20 2013-01-23 Mentor Worldwide LLC Verfahren zur herstellung eines injizierbaren polymerhydrogels
WO2005113608A1 (en) * 2004-05-20 2005-12-01 Mentor Corporation Method of covalently linking hyaluronan and chitosan
MXPA04005080A (es) * 2004-05-27 2005-11-30 Aspid S A De C V Una composicion moduladora de la inflamacion articular cronica a base de colagena-polivinilpirrolidona.
EP1773417A1 (de) * 2004-06-23 2007-04-18 Angiotech Pharmaceuticals (US), Inc. Verfahren und vernetzte polymer-zusammensetzungen für die knorpelreparatur
CA2910494C (en) 2004-07-19 2018-10-23 Biocon Limited Insulin-oligomer conjugates, formulations and uses thereof
US20060025848A1 (en) * 2004-07-29 2006-02-02 Jan Weber Medical device having a coating layer with structural elements therein and method of making the same
US8357391B2 (en) 2004-07-30 2013-01-22 Advanced Cardiovascular Systems, Inc. Coatings for implantable devices comprising poly (hydroxy-alkanoates) and diacid linkages
AU2005268647B2 (en) * 2004-08-03 2011-04-14 Tissuemed Limited Tissue-adhesive materials
WO2006034128A2 (en) 2004-09-17 2006-03-30 Angiotech Biomaterials Corporation Multifunctional compounds for forming crosslinked biomaterials and methods of preparation and use
US8790632B2 (en) * 2004-10-07 2014-07-29 Actamax Surgical Materials, Llc Polymer-based tissue-adhesive form medical use
EP1796746B1 (de) 2004-10-07 2011-05-04 E.I. Du Pont De Nemours And Company Polymer auf basis von polysaccharide für gewebekleber zur medizinischen verwendung
US7938307B2 (en) 2004-10-18 2011-05-10 Tyco Healthcare Group Lp Support structures and methods of using the same
US7845536B2 (en) 2004-10-18 2010-12-07 Tyco Healthcare Group Lp Annular adhesive structure
JP4885866B2 (ja) 2004-10-25 2012-02-29 セロノヴァ バイオサイエンスィズ ジャーマニー ゲーエムベーハー 治療適用および／または診断適用のための充填可能なポリホスファゼン含有粒子、ならびにその調製方法および使用方法
US9107850B2 (en) 2004-10-25 2015-08-18 Celonova Biosciences, Inc. Color-coded and sized loadable polymeric particles for therapeutic and/or diagnostic applications and methods of preparing and using the same
US20210299056A9 (en) 2004-10-25 2021-09-30 Varian Medical Systems, Inc. Color-Coded Polymeric Particles of Predetermined Size for Therapeutic and/or Diagnostic Applications and Related Methods
US9114162B2 (en) 2004-10-25 2015-08-25 Celonova Biosciences, Inc. Loadable polymeric particles for enhanced imaging in clinical applications and methods of preparing and using the same
CA2585215A1 (en) * 2004-10-28 2006-05-11 Surmodics, Inc. Pro-fibrotic coatings comprising collagen for medical implants
US20060095121A1 (en) * 2004-10-28 2006-05-04 Medtronic Vascular, Inc. Autologous platelet gel on a stent graft
US20060100138A1 (en) * 2004-11-10 2006-05-11 Olsen David R Implantable collagen compositions
FR2877846B1 (fr) * 2004-11-15 2008-12-05 Univ Lille Sciences Tech Biomateriaux porteurs de cyclodextrines aux proprietes d'absorption ameliorees et de liberation progressive et retardee de molecules therapeutiques
US8419656B2 (en) * 2004-11-22 2013-04-16 Bard Peripheral Vascular, Inc. Post decompression marker introducer system
US8283414B2 (en) * 2004-11-23 2012-10-09 The Johns Hopkins University Compositions comprising modified collagen and uses therefor
US20060178696A1 (en) * 2005-02-04 2006-08-10 Porter Stephen C Macroporous materials for use in aneurysms
US9050393B2 (en) 2005-02-08 2015-06-09 Bruce N. Saffran Medical devices and methods for modulation of physiology using device-based surface chemistry
EP1846505B1 (de) 2005-02-09 2015-11-11 Covidien LP Synthetische dichtungsmittel
US9364229B2 (en) 2005-03-15 2016-06-14 Covidien Lp Circular anastomosis structures
DE602006006663D1 (de) * 2005-03-24 2009-06-18 Medtronic Inc Modifizierung von thermoplastischen polymeren
MX2007011591A (es) * 2005-03-30 2007-12-10 Wyeth Corp Metodo para estimular el crecimiento de cabello administrando bmps.
CA2604696C (en) 2005-04-15 2015-03-24 Interface Biologics, Inc. Polymer-biologically active agent complexes for localized delivery of said biologically active agent
US8828433B2 (en) * 2005-04-19 2014-09-09 Advanced Cardiovascular Systems, Inc. Hydrogel bioscaffoldings and biomedical device coatings
US9539410B2 (en) 2005-04-19 2017-01-10 Abbott Cardiovascular Systems Inc. Methods and compositions for treating post-cardial infarction damage
US8303972B2 (en) 2005-04-19 2012-11-06 Advanced Cardiovascular Systems, Inc. Hydrogel bioscaffoldings and biomedical device coatings
US20080125745A1 (en) 2005-04-19 2008-05-29 Shubhayu Basu Methods and compositions for treating post-cardial infarction damage
US8187621B2 (en) 2005-04-19 2012-05-29 Advanced Cardiovascular Systems, Inc. Methods and compositions for treating post-myocardial infarction damage
US10357328B2 (en) 2005-04-20 2019-07-23 Bard Peripheral Vascular, Inc. and Bard Shannon Limited Marking device with retractable cannula
US20060247776A1 (en) * 2005-05-02 2006-11-02 The Board Of Trustees Of The Leland Stanford Junior University Systems and methods for augmenting intervertebral discs
AU2006245950B2 (en) 2005-05-09 2012-01-12 Biosphere Medical S.A. Compositions and methods using microspheres and non-ionic contrast agents
US20070005140A1 (en) * 2005-06-29 2007-01-04 Kim Daniel H Fabrication and use of biocompatible materials for treating and repairing herniated spinal discs
KR20080026198A (ko) * 2005-06-30 2008-03-24 안트로제네시스 코포레이션 태반 유도된 콜라겐 바이오패브릭을 사용한 고막의 복원
WO2007016622A2 (en) * 2005-08-02 2007-02-08 Wright Medical Technolody, Inc. Gel composition for inhibiting cellular adhesion
US8679537B2 (en) * 2005-08-24 2014-03-25 Actamaz Surgical Materials, LLC Methods for sealing an orifice in tissue using an aldol-crosslinked polymeric hydrogel adhesive
US8679536B2 (en) * 2005-08-24 2014-03-25 Actamax Surgical Materials, Llc Aldol-crosslinked polymeric hydrogel adhesives
CA2562580C (en) 2005-10-07 2014-04-29 Inrad, Inc. Drug-eluting tissue marker
CA2635374C (en) 2006-01-11 2015-12-08 Hyperbranch Medical Technology, Inc. Crosslinked gels comprising polyalkyleneimines, and their uses as medical devices
JPWO2007083522A1 (ja) * 2006-01-18 2009-06-11 株式会社ネクスト２１ 医療用ゲル形成組成物，その組成物の投与デバイス及び薬剤放出制御担体
US20080033366A1 (en) 2006-01-30 2008-02-07 Surgica Corporation Compressible intravascular embolization particles and related methods and delivery systems
EP2368581B1 (de) * 2006-01-30 2018-08-29 Biosphere Medical, Inc. Poröse intravaskuläre Embolisierungspartikel und zugehörige Verfahren
US8133336B2 (en) 2006-02-03 2012-03-13 Tissuemed Limited Tissue-adhesive materials
US20070184087A1 (en) 2006-02-06 2007-08-09 Bioform Medical, Inc. Polysaccharide compositions for use in tissue augmentation
US8623026B2 (en) 2006-02-06 2014-01-07 Conformis, Inc. Patient selectable joint arthroplasty devices and surgical tools incorporating anatomical relief
CA2641241A1 (en) 2006-02-06 2007-08-16 Conformis, Inc. Patient selectable joint arthroplasty devices and surgical tools
US20070233219A1 (en) * 2006-02-16 2007-10-04 Bilal Shafi Polymeric heart restraint
US20070233252A1 (en) * 2006-02-23 2007-10-04 Kim Daniel H Devices, systems and methods for treating intervertebral discs
US20090018575A1 (en) * 2006-03-01 2009-01-15 Tissuemed Limited Tissue-adhesive formulations
WO2007127198A2 (en) 2006-04-24 2007-11-08 Incept, Llc Protein crosslinkers, crosslinking methods and applications thereof
ATE542583T1 (de) 2006-05-22 2012-02-15 Univ Columbia Verfahren für membranlosen mikrofluidaustausch in einem h-filter und filterung der extraktionsflüssigkeitsausgangsströme
MX2008014847A (es) 2006-05-31 2009-04-30 Baxter Int Metodo para crecimiento interno en la celula dirigido y regeneracion controlada de los tejidos en la cirugia espinal.
CA2656044C (en) 2006-06-22 2015-10-20 University Of South Florida Collagen scaffolds, medical implants with same and methods of use
US7732190B2 (en) 2006-07-31 2010-06-08 Advanced Cardiovascular Systems, Inc. Modified two-component gelation systems, methods of use and methods of manufacture
TWI436793B (zh) 2006-08-02 2014-05-11 Baxter Int 快速作用之乾密封膠及其使用和製造方法
US20090171198A1 (en) * 2006-08-04 2009-07-02 Jones Michael L Powdered marker
US7945307B2 (en) * 2006-08-04 2011-05-17 Senorx, Inc. Marker delivery system with obturator
US8105634B2 (en) * 2006-08-15 2012-01-31 Anthrogenesis Corporation Umbilical cord biomaterial for medical use
US9242005B1 (en) 2006-08-21 2016-01-26 Abbott Cardiovascular Systems Inc. Pro-healing agent formulation compositions, methods and treatments
WO2008033505A1 (en) * 2006-09-13 2008-03-20 University Of South Florida Biocomposite for artificial tissue design
US20080131522A1 (en) * 2006-10-03 2008-06-05 Qing Liu Use of placental biomaterial for ocular surgery
US8071135B2 (en) 2006-10-04 2011-12-06 Anthrogenesis Corporation Placental tissue compositions
NZ597223A (en) 2006-10-06 2013-09-27 Anthrogenesis Corp Native (telopeptide) placental collagen compositions
ES2443526T3 (es) 2006-10-23 2014-02-19 C.R. Bard, Inc. Marcador mamario
US7845533B2 (en) 2007-06-22 2010-12-07 Tyco Healthcare Group Lp Detachable buttress material retention systems for use with a surgical stapling device
CN101626682B (zh) 2006-10-27 2014-04-16 爱德华兹生命科学公司 用于外科植入的生物组织
US9005672B2 (en) 2006-11-17 2015-04-14 Abbott Cardiovascular Systems Inc. Methods of modifying myocardial infarction expansion
CN101541857B (zh) * 2006-11-27 2012-12-12 阿克塔马克斯手术器材有限责任公司 多官能聚环氧烷、水凝胶和组织粘合剂
US8192760B2 (en) 2006-12-04 2012-06-05 Abbott Cardiovascular Systems Inc. Methods and compositions for treating tissue using silk proteins
EP3542748B1 (de) 2006-12-12 2023-08-16 C. R. Bard, Inc. Gewebemarker mit mehreren bildgebungsmodi
US8401622B2 (en) 2006-12-18 2013-03-19 C. R. Bard, Inc. Biopsy marker with in situ-generated imaging properties
ITRM20060682A1 (it) * 2006-12-19 2008-06-20 Sicit Chemitech S P A Nuovi derivati polimerici biodegradabili
US9056151B2 (en) 2007-02-12 2015-06-16 Warsaw Orthopedic, Inc. Methods for collagen processing and products using processed collagen
EP2591756A1 (de) 2007-02-14 2013-05-15 Conformis, Inc. Implantat und Herstellungsverfahren
US20090227689A1 (en) * 2007-03-05 2009-09-10 Bennett Steven L Low-Swelling Biocompatible Hydrogels
US20090227981A1 (en) * 2007-03-05 2009-09-10 Bennett Steven L Low-Swelling Biocompatible Hydrogels
US20080220047A1 (en) 2007-03-05 2008-09-11 Sawhney Amarpreet S Low-swelling biocompatible hydrogels
CA2680148C (en) 2007-03-06 2015-09-01 Tyco Healthcare Group Lp Surgical stapling apparatus
PL2136850T3 (pl) 2007-04-13 2012-07-31 Kuros Biosurgery Ag Polimeryczny uszczelniacz tkankowy
EP2152743A2 (de) * 2007-05-23 2010-02-17 Allergan, Inc. Quervernetztes collagen und anwendungen davon
US7665646B2 (en) 2007-06-18 2010-02-23 Tyco Healthcare Group Lp Interlocking buttress material retention system
EP2162101B1 (de) 2007-06-25 2019-02-20 MicroVention, Inc. Selbstexpandierende prothese
US20090004455A1 (en) * 2007-06-27 2009-01-01 Philippe Gravagna Reinforced composite implant
US8932619B2 (en) * 2007-06-27 2015-01-13 Sofradim Production Dural repair material
US9125807B2 (en) 2007-07-09 2015-09-08 Incept Llc Adhesive hydrogels for ophthalmic drug delivery
WO2009007247A1 (en) * 2007-07-12 2009-01-15 Basf Se Nitrocellulose based dispersant
US20090018655A1 (en) * 2007-07-13 2009-01-15 John Brunelle Composite Implant for Surgical Repair
US20090035249A1 (en) * 2007-08-02 2009-02-05 Bhatia Sujata K Method of inhibiting proliferation of Escherichia coli
GB0715514D0 (en) * 2007-08-10 2007-09-19 Tissuemed Ltd Coated medical devices
US8067028B2 (en) * 2007-08-13 2011-11-29 Confluent Surgical Inc. Drug delivery device
US20090068250A1 (en) 2007-09-07 2009-03-12 Philippe Gravagna Bioresorbable and biocompatible compounds for surgical use
US20090088723A1 (en) * 2007-09-28 2009-04-02 Accessclosure, Inc. Apparatus and methods for treating pseudoaneurysms
US8697044B2 (en) 2007-10-09 2014-04-15 Allergan, Inc. Crossed-linked hyaluronic acid and collagen and uses thereof
ES2664822T3 (es) 2007-10-16 2018-04-23 Biocon Limited Una composición farmacéutica sólida administrable por vía oral y un proceso de la misma
US20090110738A1 (en) * 2007-10-26 2009-04-30 Celonova Biosciences, Inc. Loadable Polymeric Particles for Cosmetic and Reconstructive Tissue Augmentation Applications and Methods of Preparing and Using the Same
US20090111763A1 (en) * 2007-10-26 2009-04-30 Celonova Biosciences, Inc. Loadable polymeric particles for bone augmentation and methods of preparing and using the same
US20090110730A1 (en) * 2007-10-30 2009-04-30 Celonova Biosciences, Inc. Loadable Polymeric Particles for Marking or Masking Individuals and Methods of Preparing and Using the Same
US8790698B2 (en) 2007-10-30 2014-07-29 Baxter International Inc. Use of a regenerative biofunctional collagen biomatrix for treating visceral or parietal defects
US20090110731A1 (en) * 2007-10-30 2009-04-30 Celonova Biosciences, Inc. Loadable Polymeric Microparticles for Therapeutic Use in Alopecia and Methods of Preparing and Using the Same
EP2214730B1 (de) * 2007-11-14 2014-09-24 Actamax Surgical Materials LLC Auf dextran basierendes polymergewebehaftmittel zur medizinischen verwendung
WO2009064963A2 (en) * 2007-11-14 2009-05-22 E. I. Du Pont De Nemours And Company Oxidized cationic polysaccharide-based polymer tissue adhesive for medical use
JP5670196B2 (ja) 2007-11-16 2015-02-18 バイセプト セラピューティクス、インク． 紫斑を治療する組成物および方法
US8394782B2 (en) * 2007-11-30 2013-03-12 Allergan, Inc. Polysaccharide gel formulation having increased longevity
US8394784B2 (en) * 2007-11-30 2013-03-12 Allergan, Inc. Polysaccharide gel formulation having multi-stage bioactive agent delivery
US20090143348A1 (en) * 2007-11-30 2009-06-04 Ahmet Tezel Polysaccharide gel compositions and methods for sustained delivery of drugs
US9308068B2 (en) 2007-12-03 2016-04-12 Sofradim Production Implant for parastomal hernia
US9700584B2 (en) * 2007-12-21 2017-07-11 Rti Surgical, Inc. Osteoinductive putties and methods of making and using such putties
WO2009086483A2 (en) * 2007-12-26 2009-07-09 Gel-Del Technologies, Inc. Biocompatible protein particles, particle devices and methods thereof
US8311610B2 (en) * 2008-01-31 2012-11-13 C. R. Bard, Inc. Biopsy tissue marker
JP2011514182A (ja) 2008-02-04 2011-05-06 ザ トラスティーズ オブ コロンビア ユニバーシティ イン ザ シティ オブ ニューヨーク 流体分離装置、システム、及び方法
WO2009102952A2 (en) * 2008-02-13 2009-08-20 Hyperbranch Medical Technology, Inc. Crosslinked polyalkyleneimine hydrogels with tunable degradation rates
CN102006837B (zh) * 2008-02-14 2014-12-24 坦吉恩股份有限公司 组织工程支架
EP2259803B2 (de) 2008-02-29 2019-03-13 Ferrosan Medical Devices A/S Vorrichtung zur förderung von hämostase und/oder wundheilung
US8293813B2 (en) * 2008-03-05 2012-10-23 Biomet Manufacturing Corporation Cohesive and compression resistant demineralized bone carrier matrix
WO2009111626A2 (en) 2008-03-05 2009-09-11 Conformis, Inc. Implants for altering wear patterns of articular surfaces
US20090227976A1 (en) * 2008-03-05 2009-09-10 Calabria Marie F Multiple biocompatible polymeric strand aneurysm embolization system and method
JP2011519713A (ja) 2008-05-12 2011-07-14 コンフォーミス・インコーポレイテッド 面関節および他の関節の治療のためのデバイスならびに方法
WO2009148985A2 (en) * 2008-06-03 2009-12-10 E. I. Du Pont De Nemours And Company A tissue coating for preventing undesired tissue-to-tissue adhesions
US9242026B2 (en) 2008-06-27 2016-01-26 Sofradim Production Biosynthetic implant for soft tissue repair
US8551136B2 (en) 2008-07-17 2013-10-08 Actamax Surgical Materials, Llc High swell, long-lived hydrogel sealant
US20100015231A1 (en) * 2008-07-17 2010-01-21 E.I. Du Pont De Nemours And Company Low swell, long-lived hydrogel sealant
US8357795B2 (en) 2008-08-04 2013-01-22 Allergan, Inc. Hyaluronic acid-based gels including lidocaine
US9271706B2 (en) 2008-08-12 2016-03-01 Covidien Lp Medical device for wound closure and method of use
WO2010022180A1 (en) 2008-08-19 2010-02-25 Micro Therapeutics, Inc. Detachable tip microcatheter
ES2829971T3 (es) 2008-09-02 2021-06-02 Tautona Group Lp Hilos de ácido hialurónico y/o derivados de los mismos, métodos para fabricar los mismos y usos de los mismos
US9387280B2 (en) * 2008-09-05 2016-07-12 Synovis Orthopedic And Woundcare, Inc. Device for soft tissue repair or replacement
US9327061B2 (en) 2008-09-23 2016-05-03 Senorx, Inc. Porous bioabsorbable implant
US8119742B2 (en) * 2008-09-28 2012-02-21 Knc Ner Acquisition Sub, Inc. Multi-armed catechol compound blends
CA2976265C (en) 2008-10-09 2019-03-19 Mimedx Group, Inc. Methods of making collagen fiber medical constructs and related medical constructs, including nerve guides and patches
JP2012507562A (ja) * 2008-10-30 2012-03-29 ダビド リウ 微小球性多孔質生体適合性足場並びにその製造方法及び装置
WO2010053918A1 (en) 2008-11-05 2010-05-14 Hancock Jaffe Laboratories, Inc. Composite containing collagen and elastin as a dermal expander and tissue filler
WO2010057177A2 (en) 2008-11-17 2010-05-20 Gel-Del Technologies, Inc. Protein biomaterial and biocoacervate vessel graft systems and methods of making and using thereof
US8466327B2 (en) 2008-11-19 2013-06-18 Actamax Surgical Materials, Llc Aldehyde-functionalized polyethers and method of making same
WO2010059279A2 (en) * 2008-11-19 2010-05-27 E. I. Du Pont De Nemours And Company Hydrogel tissue adhesive formed from aminated polysaccharide and aldehyde-functionalized multi-arm polyether
JP5564058B2 (ja) * 2008-12-10 2014-07-30 マイクロベンション インコーポレイテッド マイクロカテーテル
US20100147921A1 (en) 2008-12-16 2010-06-17 Lee Olson Surgical Apparatus Including Surgical Buttress
US20100160960A1 (en) * 2008-12-19 2010-06-24 E. I. Du Pont De Nemours And Company Hydrogel tissue adhesive having increased degradation time
CA2742765C (en) * 2008-12-30 2016-04-12 C.R. Bard Inc. Marker delivery device for tissue marker placement
WO2010076282A1 (en) 2008-12-31 2010-07-08 Shell Internationale Research Maatschappij B.V. Minimal gas processing scheme for recycling co2 in a co2 enhanced oil recovery flood
US20100204570A1 (en) * 2009-02-06 2010-08-12 Paul Lubock Anchor markers
EP2396070A4 (de) 2009-02-12 2012-09-19 Incept Llc Wirkstofffreisetzung mit hydrogel-plugs
US9017334B2 (en) 2009-02-24 2015-04-28 Microport Orthopedics Holdings Inc. Patient specific surgical guide locator and mount
US8808297B2 (en) 2009-02-24 2014-08-19 Microport Orthopedics Holdings Inc. Orthopedic surgical guide
WO2010099231A2 (en) 2009-02-24 2010-09-02 Conformis, Inc. Automated systems for manufacturing patient-specific orthopedic implants and instrumentation
US8808303B2 (en) 2009-02-24 2014-08-19 Microport Orthopedics Holdings Inc. Orthopedic surgical guide
US9486215B2 (en) 2009-03-31 2016-11-08 Covidien Lp Surgical stapling apparatus
EP2416811B1 (de) 2009-04-09 2015-09-09 Actamax Surgical Materials LLC Hydrogel-gewebekleber mit verringerter zerfallszeit
SG10201401326SA (en) 2009-04-16 2014-10-30 Conformis Inc Patient-specific joint arthroplasty devices for ligament repair
US9039783B2 (en) 2009-05-18 2015-05-26 Baxter International, Inc. Method for the improvement of mesh implant biocompatibility
KR101699992B1 (ko) 2009-06-16 2017-01-26 백스터 인터내셔널 인코포레이티드 지혈용 스펀지
WO2011002956A1 (en) 2009-07-02 2011-01-06 E. I. Du Pont De Nemours And Company Aldehyde-functionalized polysaccharides
US8796242B2 (en) 2009-07-02 2014-08-05 Actamax Surgical Materials, Llc Hydrogel tissue adhesive for medical use
ES2574238T3 (es) 2009-07-02 2016-06-16 Actamax Surgical Materials Llc Adhesivo tisular de hidrogel para uso médico
US8580950B2 (en) 2009-07-02 2013-11-12 Actamax Surgical Materials, Llc Aldehyde-functionalized polysaccharides
CA2769470A1 (en) 2009-07-30 2011-02-03 Carbylan Biosurgery, Inc. Modified hyaluronic acid polymer compositions and related methods
FR2949688B1 (fr) 2009-09-04 2012-08-24 Sofradim Production Tissu avec picots revetu d'une couche microporeuse bioresorbable
US20110081398A1 (en) * 2009-10-01 2011-04-07 Tyco Healthcare Group Lp Multi-mechanism surgical compositions
US8968785B2 (en) 2009-10-02 2015-03-03 Covidien Lp Surgical compositions
US20110081701A1 (en) * 2009-10-02 2011-04-07 Timothy Sargeant Surgical compositions
US9833225B2 (en) 2009-10-08 2017-12-05 Covidien Lp Wound closure device
US20110087273A1 (en) * 2009-10-08 2011-04-14 Tyco Healthcare Group Lp Wound Closure Device
US20110087274A1 (en) 2009-10-08 2011-04-14 Tyco Healtcare Group LP, New Haven, Ct Wound Closure Device
US8617206B2 (en) * 2009-10-08 2013-12-31 Covidien Lp Wound closure device
US20150231409A1 (en) 2009-10-15 2015-08-20 Covidien Lp Buttress brachytherapy and integrated staple line markers for margin identification
US10293553B2 (en) 2009-10-15 2019-05-21 Covidien Lp Buttress brachytherapy and integrated staple line markers for margin identification
US20110093057A1 (en) * 2009-10-16 2011-04-21 Confluent Surgical, Inc. Mitigating Thrombus Formation On Medical Devices By Influencing pH Microenvironment Near The Surface
US9445795B2 (en) 2009-10-16 2016-09-20 Confluent Surgical, Inc. Prevention of premature gelling of delivery devices for pH dependent forming materials
US8795727B2 (en) 2009-11-09 2014-08-05 Spotlight Technology Partners Llc Fragmented hydrogels
CN106913902A (zh) 2009-11-09 2017-07-04 聚光灯技术合伙有限责任公司 多糖基水凝胶
US8858592B2 (en) * 2009-11-24 2014-10-14 Covidien Lp Wound plugs
AU2010327987B2 (en) 2009-12-11 2015-04-02 Conformis, Inc. Patient-specific and patient-engineered orthopedic implants
EP3960215A1 (de) 2009-12-15 2022-03-02 Incept, LLC Implantate und biologisch abbaubare bezugsmarkierungen
EP2512535A1 (de) 2009-12-16 2012-10-24 Baxter International Inc Blutstillender schwamm
US20110171286A1 (en) * 2010-01-13 2011-07-14 Allergan, Inc. Hyaluronic acid compositions for dermatological use
US20110172180A1 (en) 2010-01-13 2011-07-14 Allergan Industrie. Sas Heat stable hyaluronic acid compositions for dermatological use
US9114188B2 (en) 2010-01-13 2015-08-25 Allergan, Industrie, S.A.S. Stable hydrogel compositions including additives
US20110171311A1 (en) * 2010-01-13 2011-07-14 Allergan Industrie, Sas Stable hydrogel compositions including additives
EP2353624A1 (de) 2010-02-10 2011-08-10 Université de la Méditerranée - Aix-Marseille II Emboliematerial, dessen Herstellungsverfahren und dessen therapeutische Verwendungen
US20110218606A1 (en) * 2010-03-02 2011-09-08 Medtronic Vascular, Inc. Methods for Stabilizing Femoral Vessels
US8679404B2 (en) * 2010-03-05 2014-03-25 Edwards Lifesciences Corporation Dry prosthetic heart valve packaging system
FR2957254B1 (fr) 2010-03-12 2016-10-14 Allergan Ind Sas Compositions fluides pour ameliorer les etats de la peau
CA2730598C (en) 2010-03-16 2018-03-13 Confluent Surgical, Inc. Modulating drug release rate by controlling the kinetics of the ph transition in hydrogels
PL2550027T5 (pl) 2010-03-22 2019-07-31 Allergan, Inc. Polisacharydowe i białkowo-polisacharydowe usieciowane hydrożele do powiększania tkanek miękkich
US20110243913A1 (en) * 2010-04-06 2011-10-06 Orthovita, Inc. Biomaterial Compositions and Methods of Use
SA111320355B1 (ar) * 2010-04-07 2015-01-08 Baxter Heathcare S A إسفنجة لايقاف النزف
US8790699B2 (en) 2010-04-23 2014-07-29 Warsaw Orthpedic, Inc. Foam-formed collagen strand
US8460691B2 (en) 2010-04-23 2013-06-11 Warsaw Orthopedic, Inc. Fenestrated wound repair scaffold
US8828181B2 (en) 2010-04-30 2014-09-09 E I Du Pont De Nemours And Company Temperature switchable adhesives comprising a crystallizable oil
JP2013525077A (ja) 2010-05-03 2013-06-20 テンジオン， インク． 平滑筋細胞構築物
US8697111B2 (en) 2010-05-12 2014-04-15 Covidien Lp Osteochondral implant comprising osseous phase and chondral phase
US8858577B2 (en) 2010-05-19 2014-10-14 University Of Utah Research Foundation Tissue stabilization system
US8945156B2 (en) 2010-05-19 2015-02-03 University Of Utah Research Foundation Tissue fixation
US8591929B2 (en) 2010-05-27 2013-11-26 Covidien Lp Hydrogel implants with varying degrees of crosslinking
US8968783B2 (en) 2010-05-27 2015-03-03 Covidien Lp Hydrogel implants with varying degrees of crosslinking
US8734824B2 (en) 2010-05-27 2014-05-27 Covidien LLP Hydrogel implants with varying degrees of crosslinking
US8754564B2 (en) 2010-05-27 2014-06-17 Covidien Lp Hydrogel implants with varying degrees of crosslinking
US8883185B2 (en) 2010-05-27 2014-11-11 Covidien Lp Hydrogel implants with varying degrees of crosslinking
US8591950B2 (en) 2010-05-27 2013-11-26 Covidien Lp Hydrogel implants with varying degrees of crosslinking
US8734930B2 (en) 2010-05-27 2014-05-27 Covidien Lp Hydrogel implants with varying degrees of crosslinking
CA2801118C (en) 2010-06-01 2016-01-05 Baxter International Inc. Process for making dry and stable hemostatic compositions
EP2575775B1 (de) 2010-06-01 2018-04-04 Baxter International Inc. Verfahren zur herstellung von trockenen und stabilen hämostatischen zusammensetzungen
BR112012030457B1 (pt) 2010-06-01 2021-03-09 Baxter International Inc. processo para fabricar uma composição hemostática seca e estável, recipiente acabado final, método para prover uma composição hemostática pronta para uso, e, kit para administrar uma composição hemostática
US8409703B2 (en) 2010-07-23 2013-04-02 E I Du Pont De Nemours And Company Temperature switchable adhesive assemblies with temperature non-switchable tack
US8697057B2 (en) 2010-08-19 2014-04-15 Allergan, Inc. Compositions and soft tissue replacement methods
US9005605B2 (en) 2010-08-19 2015-04-14 Allergan, Inc. Compositions and soft tissue replacement methods
US8889123B2 (en) 2010-08-19 2014-11-18 Allergan, Inc. Compositions and soft tissue replacement methods
US8883139B2 (en) 2010-08-19 2014-11-11 Allergan Inc. Compositions and soft tissue replacement methods
US8961501B2 (en) 2010-09-17 2015-02-24 Incept, Llc Method for applying flowable hydrogels to a cornea
ES2714701T3 (es) 2010-11-10 2019-05-29 Stryker European Holdings I Llc Proceso para la preparación de una espuma ósea polimérica
US9498317B2 (en) 2010-12-16 2016-11-22 Edwards Lifesciences Corporation Prosthetic heart valve delivery systems and packaging
US9801980B2 (en) * 2010-12-20 2017-10-31 Microvention, Inc. Polymer stents and methods of manufacture
US8518440B2 (en) 2010-12-21 2013-08-27 Confluent Surgical, Inc. Biodegradable osmotic pump implant for drug delivery
US8551525B2 (en) 2010-12-23 2013-10-08 Biostructures, Llc Bone graft materials and methods
US8360765B2 (en) 2011-01-07 2013-01-29 Covidien Lp Systems and method for forming a coaxial implant
US8852214B2 (en) 2011-02-04 2014-10-07 University Of Utah Research Foundation System for tissue fixation to bone
JP5828643B2 (ja) * 2011-02-14 2015-12-09 学校法人 関西大学 ゼラチン水溶液を用いた弾性に富む繊維ならびに中空糸の乾式紡糸法
CN103476363B (zh) 2011-02-15 2017-06-30 康复米斯公司 改进的适合患者型关节植入物以及处理、评估、校正、修改和/或适应解剖变化和/或非对称性的手术和工具
CN103384536B (zh) * 2011-02-21 2015-11-25 株式会社阿托利 胶原材料及胶原材料的制造方法
JP6066931B2 (ja) 2011-02-25 2017-01-25 マイクロベンション インコーポレイテッド 補強されたバルーンカテーテル
US8479968B2 (en) 2011-03-10 2013-07-09 Covidien Lp Surgical instrument buttress attachment
FR2972626B1 (fr) 2011-03-16 2014-04-11 Sofradim Production Prothese comprenant un tricot tridimensionnel et ajoure
US10028745B2 (en) 2011-03-30 2018-07-24 Noha, Llc Advanced endovascular clip and method of using same
US9265830B2 (en) 2011-04-20 2016-02-23 Warsaw Orthopedic, Inc. Implantable compositions and methods for preparing the same
JP2014522263A (ja) 2011-05-11 2014-09-04 マイクロベンション インコーポレイテッド 内腔を閉塞するためのデバイス
US20130096081A1 (en) 2011-06-03 2013-04-18 Allergan, Inc. Dermal filler compositions
CN107412002A (zh) 2011-06-03 2017-12-01 阿勒根公司 包括抗氧化剂的皮肤填充剂组合物
US9393263B2 (en) 2011-06-03 2016-07-19 Allergan, Inc. Dermal filler compositions including antioxidants
US9408797B2 (en) 2011-06-03 2016-08-09 Allergan, Inc. Dermal filler compositions for fine line treatment
WO2012173555A1 (en) * 2011-06-13 2012-12-20 Dentsply Ih Ab Collagen coated article
CN103619886B (zh) 2011-06-29 2016-09-14 柯惠Lp公司 氧化纤维素的溶解
FR2977789B1 (fr) 2011-07-13 2013-07-19 Sofradim Production Prothese pour hernie ombilicale
FR2977790B1 (fr) 2011-07-13 2013-07-19 Sofradim Production Prothese pour hernie ombilicale
EP2736545B1 (de) 2011-07-28 2016-01-06 Harbor Medtech, Inc. Vernetzte menschliche oder tierische gewebeprodukte sowie verfahren zu ihrer herstellung und verwendung
US9662422B2 (en) 2011-09-06 2017-05-30 Allergan, Inc. Crosslinked hyaluronic acid-collagen gels for improving tissue graft viability and soft tissue augmentation
US20130244943A1 (en) 2011-09-06 2013-09-19 Allergan, Inc. Hyaluronic acid-collagen matrices for dermal filling and volumizing applications
US10226417B2 (en) 2011-09-16 2019-03-12 Peter Jarrett Drug delivery systems and applications
WO2013046057A1 (en) 2011-09-30 2013-04-04 Sofradim Production Multilayer implants for delivery of therapeutic agents
WO2013046058A2 (en) 2011-09-30 2013-04-04 Sofradim Production Reversible stiffening of light weight mesh
JP6195568B2 (ja) 2011-10-11 2017-09-13 バクスター・インターナショナル・インコーポレイテッドＢａｘｔｅｒ Ｉｎｔｅｒｎａｔｉｏｎａｌ Ｉｎｃｏｒｐ０Ｒａｔｅｄ 止血組成物
KR102102002B1 (ko) 2011-10-11 2020-04-20 백스터 인터내셔널 인코포레이티드 지혈 조성물
PL2771027T3 (pl) 2011-10-27 2016-01-29 Baxter Int Kompozycje hemostatyczne
US8584920B2 (en) 2011-11-04 2013-11-19 Covidien Lp Surgical stapling apparatus including releasable buttress
WO2013086015A1 (en) 2011-12-05 2013-06-13 Incept, Llc Medical organogel processes and compositions
US9113885B2 (en) 2011-12-14 2015-08-25 Covidien Lp Buttress assembly for use with surgical stapling device
US9351731B2 (en) 2011-12-14 2016-05-31 Covidien Lp Surgical stapling apparatus including releasable surgical buttress
US9237892B2 (en) 2011-12-14 2016-01-19 Covidien Lp Buttress attachment to the cartridge surface
US8967448B2 (en) 2011-12-14 2015-03-03 Covidien Lp Surgical stapling apparatus including buttress attachment via tabs
FR2985271B1 (fr) 2011-12-29 2014-01-24 Sofradim Production Tricot a picots
FR2985170B1 (fr) 2011-12-29 2014-01-24 Sofradim Production Prothese pour hernie inguinale
KR101444877B1 (ko) 2011-12-30 2014-10-01 주식회사 삼양바이오팜 감마폴리글루탐산으로 구성된 현장 가교 수화겔 및 그의 제조 방법
US9326773B2 (en) 2012-01-26 2016-05-03 Covidien Lp Surgical device including buttress material
US9010612B2 (en) 2012-01-26 2015-04-21 Covidien Lp Buttress support design for EEA anvil
US9010609B2 (en) 2012-01-26 2015-04-21 Covidien Lp Circular stapler including buttress
US8820606B2 (en) 2012-02-24 2014-09-02 Covidien Lp Buttress retention system for linear endostaplers
IN2014DN08122A (de) 2012-03-06 2015-05-01 Ferrosan Medical Devices As
US9486226B2 (en) 2012-04-18 2016-11-08 Conformis, Inc. Tibial guides, tools, and techniques for resecting the tibial plateau
US9168227B2 (en) 2012-05-31 2015-10-27 Covidien Lp Multi-encapsulated microspheres made with oxidized cellulose for in-situ reactions
US9271937B2 (en) 2012-05-31 2016-03-01 Covidien Lp Oxidized cellulose microspheres
US9675471B2 (en) 2012-06-11 2017-06-13 Conformis, Inc. Devices, techniques and methods for assessing joint spacing, balancing soft tissues and obtaining desired kinematics for joint implant components
EP2977066A3 (de) 2012-06-12 2016-07-27 Ferrosan Medical Devices A/S Trockene blutstillende zusammensetzung
US10124087B2 (en) 2012-06-19 2018-11-13 Covidien Lp Detachable coupling for catheter
US9499636B2 (en) 2012-06-28 2016-11-22 Covidien Lp Dissolution of oxidized cellulose and particle preparation by cross-linking with multivalent cations
US10835241B2 (en) 2012-07-30 2020-11-17 Conextions, Inc. Devices, systems, and methods for repairing soft tissue and attaching soft tissue to bone
US11944531B2 (en) 2012-07-30 2024-04-02 Conextions, Inc. Devices, systems, and methods for repairing soft tissue and attaching soft tissue to bone
US11253252B2 (en) 2012-07-30 2022-02-22 Conextions, Inc. Devices, systems, and methods for repairing soft tissue and attaching soft tissue to bone
US10390935B2 (en) 2012-07-30 2019-08-27 Conextions, Inc. Soft tissue to bone repair devices, systems, and methods
US9629632B2 (en) 2012-07-30 2017-04-25 Conextions, Inc. Soft tissue repair devices, systems, and methods
US9427309B2 (en) 2012-07-30 2016-08-30 Conextions, Inc. Soft tissue repair devices, systems, and methods
US10219804B2 (en) 2012-07-30 2019-03-05 Conextions, Inc. Devices, systems, and methods for repairing soft tissue and attaching soft tissue to bone
FR2994185B1 (fr) 2012-08-02 2015-07-31 Sofradim Production Procede de preparation d’une couche poreuse a base de chitosane
US20140048580A1 (en) 2012-08-20 2014-02-20 Covidien Lp Buttress attachment features for surgical stapling apparatus
CA2826786A1 (en) 2012-09-17 2014-03-17 Confluent Surgical, Inc. Multi-encapsulated formulations made with oxidized cellulose
FR2995779B1 (fr) 2012-09-25 2015-09-25 Sofradim Production Prothese comprenant un treillis et un moyen de consolidation
FR2995788B1 (fr) 2012-09-25 2014-09-26 Sofradim Production Patch hemostatique et procede de preparation
FR2995778B1 (fr) 2012-09-25 2015-06-26 Sofradim Production Prothese de renfort de la paroi abdominale et procede de fabrication
EP2900174B1 (de) 2012-09-28 2017-04-12 Sofradim Production Verpackung für eine bruchoperationsvorrichtung
US9161753B2 (en) 2012-10-10 2015-10-20 Covidien Lp Buttress fixation for a circular stapler
US20140131418A1 (en) 2012-11-09 2014-05-15 Covidien Lp Surgical Stapling Apparatus Including Buttress Attachment
US8859705B2 (en) 2012-11-19 2014-10-14 Actamax Surgical Materials Llc Hydrogel tissue adhesive having decreased gelation time and decreased degradation time
US9597426B2 (en) 2013-01-25 2017-03-21 Covidien Lp Hydrogel filled barbed suture
US20140212355A1 (en) 2013-01-28 2014-07-31 Abbott Cardiovascular Systems Inc. Trans-arterial drug delivery
US20140239047A1 (en) 2013-02-28 2014-08-28 Covidien Lp Adherence concepts for non-woven absorbable felt buttresses
ES2678875T3 (es) 2013-03-04 2018-08-20 DERMELLE, LLC d/b/a ETERNOGEN, LLC Composición de colágeno polimerizable in situ inyectable
US9782173B2 (en) 2013-03-07 2017-10-10 Covidien Lp Circular stapling device including buttress release mechanism
US9782430B2 (en) 2013-03-15 2017-10-10 Covidien Lp Resorbable oxidized cellulose embolization solution
US10328095B2 (en) 2013-03-15 2019-06-25 Covidien Lp Resorbable oxidized cellulose embolization microspheres
US10413566B2 (en) 2013-03-15 2019-09-17 Covidien Lp Thixotropic oxidized cellulose solutions and medical applications thereof
FR3006581B1 (fr) 2013-06-07 2016-07-22 Sofradim Production Prothese a base d’un textile pour voie laparoscopique
FR3006578B1 (fr) 2013-06-07 2015-05-29 Sofradim Production Prothese a base d’un textile pour voie laparoscopique
US9775928B2 (en) 2013-06-18 2017-10-03 Covidien Lp Adhesive barbed filament
CA2912357C (en) 2013-06-21 2019-12-31 Ferrosan Medical Devices A/S Vacuum expanded dry composition and syringe for retaining same
WO2015017340A2 (en) 2013-07-29 2015-02-05 Actamax Surgical Materials, Llc Low swell tissue adhesive and sealant formulations
USD716450S1 (en) 2013-09-24 2014-10-28 C. R. Bard, Inc. Tissue marker for intracorporeal site identification
USD716451S1 (en) 2013-09-24 2014-10-28 C. R. Bard, Inc. Tissue marker for intracorporeal site identification
USD715942S1 (en) 2013-09-24 2014-10-21 C. R. Bard, Inc. Tissue marker for intracorporeal site identification
USD715442S1 (en) 2013-09-24 2014-10-14 C. R. Bard, Inc. Tissue marker for intracorporeal site identification
US10173357B2 (en) 2013-09-26 2019-01-08 Northwestern University Poly(ethylene glycol) cross-linking of soft materials to tailor viscoelastic properties for bioprinting
WO2015080144A1 (ja) 2013-11-26 2015-06-04 住友化学株式会社 ゴム組成物及び加硫助剤
EP3079731B1 (de) 2013-12-11 2018-08-08 Ferrosan Medical Devices A/S Trockenzusammensetzung mit extrusionsverstärker
US10617788B2 (en) * 2014-01-28 2020-04-14 Mccoy Enterprises, Llc Collagen permeated medical implants
US11583384B2 (en) 2014-03-12 2023-02-21 Conextions, Inc. Devices, systems, and methods for repairing soft tissue and attaching soft tissue to bone
US9844378B2 (en) 2014-04-29 2017-12-19 Covidien Lp Surgical stapling apparatus and methods of adhering a surgical buttress thereto
EP3000489B1 (de) 2014-09-24 2017-04-05 Sofradim Production Verfahren zur Herstellung einer Antihaft-Sperrschicht
US10449152B2 (en) 2014-09-26 2019-10-22 Covidien Lp Drug loaded microspheres for post-operative chronic pain
EP3000433B1 (de) 2014-09-29 2022-09-21 Sofradim Production Vorrichtung zur Einführung einer Prothese zur Hernie-Behandlung in einen Einschnitt und flexible textile Prothese
EP3000432B1 (de) 2014-09-29 2022-05-04 Sofradim Production Textilbasierte Prothese für die Behandlung von Leistenbruch
US10722444B2 (en) 2014-09-30 2020-07-28 Allergan Industrie, Sas Stable hydrogel compositions including additives
US11046818B2 (en) 2014-10-13 2021-06-29 Ferrosan Medical Devices A/S Dry composition for use in haemostasis and wound healing
US10550187B2 (en) 2014-10-24 2020-02-04 Incept, Llc Extra luminal scaffold
EP3029189B1 (de) 2014-12-05 2021-08-11 Sofradim Production Prothetisches poröses Netz, sein Herstellungsverfahren und Hernienprothese
EP3229779B1 (de) 2014-12-10 2021-02-03 Incept, LLC Hydrogel-wirkstofffreisetzungsimplantate
US9238090B1 (en) 2014-12-24 2016-01-19 Fettech, Llc Tissue-based compositions
US10835216B2 (en) 2014-12-24 2020-11-17 Covidien Lp Spinneret for manufacture of melt blown nonwoven fabric
CN107206165B (zh) 2014-12-24 2020-10-23 弗罗桑医疗设备公司 用于保持并混合第一和第二物质的注射器
WO2016128783A1 (en) 2015-02-09 2016-08-18 Allergan Industrie Sas Compositions and methods for improving skin appearance
US10470767B2 (en) 2015-02-10 2019-11-12 Covidien Lp Surgical stapling instrument having ultrasonic energy delivery
EP3059255B1 (de) 2015-02-17 2020-05-13 Sofradim Production Verfahren zur Herstellung einer Matrix auf Chitosanbasis mit faseroptischem Verstärkungselement
EP3291745A4 (de) 2015-04-10 2019-02-13 Covidien LP Chirurgisches klammergerät mit integrierter blase
CA2925606A1 (en) 2015-04-23 2016-10-23 Covidien Lp Resorbable oxidized cellulose embolization solution
EP3085337B1 (de) 2015-04-24 2022-09-14 Sofradim Production Prothese zur unterstützung einer bruststruktur
AU2016261925B2 (en) 2015-05-12 2020-10-01 Incept, Llc Drug delivery from hydrogels
ES2676072T3 (es) 2015-06-19 2018-07-16 Sofradim Production Prótesis sintética que comprende un tejido de punto y una película no porosa y método para formarla
RU2717356C2 (ru) 2015-07-03 2020-03-23 Ферросан Медикал Дивайсиз А/С Шприц для удерживания вакуума в состоянии хранения
US10307168B2 (en) 2015-08-07 2019-06-04 Terumo Corporation Complex coil and manufacturing techniques
US10420724B2 (en) 2015-11-25 2019-09-24 Incept, Llc Shape changing drug delivery devices and methods
EP3195830B1 (de) 2016-01-25 2020-11-18 Sofradim Production Prothese zur hernienreparatur
US10959731B2 (en) 2016-06-14 2021-03-30 Covidien Lp Buttress attachment for surgical stapling instrument
AU2017204280A1 (en) 2016-08-12 2018-03-01 Covidien Lp Thixotropic oxidized cellulose solutions and medical applications thereof
CA3038075A1 (en) 2016-09-23 2018-03-29 Incept, Llc Intracameral drug delivery depots
US11696822B2 (en) 2016-09-28 2023-07-11 Conextions, Inc. Devices, systems, and methods for repairing soft tissue and attaching soft tissue to bone
EP3312325B1 (de) 2016-10-21 2021-09-22 Sofradim Production Verfahren zur herstellung eines netzes mit einem daran befestigten nahtmaterial mit widerhaken und dadurch erhaltenes netz
US11026686B2 (en) 2016-11-08 2021-06-08 Covidien Lp Structure for attaching buttress to anvil and/or cartridge of surgical stapling instrument
US10874768B2 (en) 2017-01-20 2020-12-29 Covidien Lp Drug eluting medical device
US10925607B2 (en) 2017-02-28 2021-02-23 Covidien Lp Surgical stapling apparatus with staple sheath
US11202848B2 (en) 2017-03-08 2021-12-21 Baxter International Inc. Surgical adhesive able to glue in wet conditions
US10912859B2 (en) 2017-03-08 2021-02-09 Baxter International Inc. Additive able to provide underwater adhesion
US10368868B2 (en) 2017-03-09 2019-08-06 Covidien Lp Structure for attaching buttress material to anvil and cartridge of surgical stapling instrument
US11096610B2 (en) 2017-03-28 2021-08-24 Covidien Lp Surgical implants including sensing fibers
EP3398554A1 (de) 2017-05-02 2018-11-07 Sofradim Production Prothese zur leistenbruch-reparatur
US10849625B2 (en) 2017-08-07 2020-12-01 Covidien Lp Surgical buttress retention systems for surgical stapling apparatus
US10945733B2 (en) 2017-08-23 2021-03-16 Covidien Lp Surgical buttress reload and tip attachment assemblies for surgical stapling apparatus
US11141151B2 (en) 2017-12-08 2021-10-12 Covidien Lp Surgical buttress for circular stapling
US11547397B2 (en) 2017-12-20 2023-01-10 Conextions, Inc. Devices, systems, and methods for repairing soft tissue and attaching soft tissue to bone
KR102245539B1 (ko) 2018-02-12 2021-04-29 주식회사 지앤피바이오사이언스 코어-쉘 구조의 마이크로 입자를 유효성분으로 포함하는 성장인자 유전자 발현 증가용 조성물
AU2019223962A1 (en) 2018-02-20 2020-09-10 Conextions, Inc. Devices, systems, and methods for repairing soft tissue and attaching soft tissue to bone
US11065000B2 (en) 2018-02-22 2021-07-20 Covidien Lp Surgical buttresses for surgical stapling apparatus
US10758237B2 (en) 2018-04-30 2020-09-01 Covidien Lp Circular stapling apparatus with pinned buttress
US11284896B2 (en) 2018-05-09 2022-03-29 Covidien Lp Surgical buttress loading and attaching/detaching assemblies
US11801324B2 (en) 2018-05-09 2023-10-31 Ferrosan Medical Devices A/S Method for preparing a haemostatic composition
US11432818B2 (en) 2018-05-09 2022-09-06 Covidien Lp Surgical buttress assemblies
US11426163B2 (en) 2018-05-09 2022-08-30 Covidien Lp Universal linear surgical stapling buttress
US11219460B2 (en) 2018-07-02 2022-01-11 Covidien Lp Surgical stapling apparatus with anvil buttress
CN113038908A (zh) * 2018-09-14 2021-06-25 生物智慧公司 用于组织工程化的生物管
US10806459B2 (en) 2018-09-14 2020-10-20 Covidien Lp Drug patterned reinforcement material for circular anastomosis
US10952729B2 (en) 2018-10-03 2021-03-23 Covidien Lp Universal linear buttress retention/release assemblies and methods
MX2021005161A (es) * 2018-11-02 2021-10-13 Covalon Tech Inc Composiciones de espuma, matrices de espuma y metodos.
EP3653171A1 (de) 2018-11-16 2020-05-20 Sofradim Production Implantate zur weichgewebereparatur
GB201905040D0 (en) 2019-04-09 2019-05-22 Cambridge Entpr Ltd Tissue equivalent scaffold structure, and methods of procution thereof
US11730472B2 (en) 2019-04-25 2023-08-22 Covidien Lp Surgical system and surgical loading units thereof
US11596403B2 (en) 2019-05-08 2023-03-07 Covidien Lp Surgical stapling device
US11478245B2 (en) 2019-05-08 2022-10-25 Covidien Lp Surgical stapling device
WO2020255113A1 (en) * 2019-06-20 2020-12-24 Datum Biotech Ltd. An implantable structure having a collagen membrane
US11571208B2 (en) 2019-10-11 2023-02-07 Covidien Lp Surgical buttress loading units
US11523824B2 (en) 2019-12-12 2022-12-13 Covidien Lp Anvil buttress loading for a surgical stapling apparatus
US11547407B2 (en) 2020-03-19 2023-01-10 Covidien Lp Staple line reinforcement for surgical stapling apparatus
US11337699B2 (en) 2020-04-28 2022-05-24 Covidien Lp Magnesium infused surgical buttress for surgical stapler
US11739166B2 (en) 2020-07-02 2023-08-29 Davol Inc. Reactive polysaccharide-based hemostatic agent
US11707276B2 (en) 2020-09-08 2023-07-25 Covidien Lp Surgical buttress assemblies and techniques for surgical stapling
US11399833B2 (en) 2020-10-19 2022-08-02 Covidien Lp Anvil buttress attachment for surgical stapling apparatus
US11534170B2 (en) 2021-01-04 2022-12-27 Covidien Lp Anvil buttress attachment for surgical stapling apparatus
US11510670B1 (en) 2021-06-23 2022-11-29 Covidien Lp Buttress attachment for surgical stapling apparatus
US11596399B2 (en) 2021-06-23 2023-03-07 Covidien Lp Anvil buttress attachment for surgical stapling apparatus
US11672538B2 (en) 2021-06-24 2023-06-13 Covidien Lp Surgical stapling device including a buttress retention assembly
US11678879B2 (en) 2021-07-01 2023-06-20 Covidien Lp Buttress attachment for surgical stapling apparatus
US11684368B2 (en) 2021-07-14 2023-06-27 Covidien Lp Surgical stapling device including a buttress retention assembly
US11801052B2 (en) 2021-08-30 2023-10-31 Covidien Lp Assemblies for surgical stapling instruments
US11751875B2 (en) 2021-10-13 2023-09-12 Coviden Lp Surgical buttress attachment assemblies for surgical stapling apparatus
US11806017B2 (en) 2021-11-23 2023-11-07 Covidien Lp Anvil buttress loading system for surgical stapling apparatus

Family Cites Families (60)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3091542A (en) * 1960-09-20 1963-05-28 Dow Chemical Co Insolubilization of water-soluble cellulose ethers
US3619371A (en) * 1967-07-03 1971-11-09 Nat Res Dev Production of a polymeric matrix having a biologically active substance bound thereto
SE343210B (de) * 1967-12-20 1972-03-06 Pharmacia Ab
US3876501A (en) * 1973-05-17 1975-04-08 Baxter Laboratories Inc Binding enzymes to activated water-soluble carbohydrates
GB1479268A (en) * 1973-07-05 1977-07-13 Beecham Group Ltd Pharmaceutical compositions
US4179337A (en) * 1973-07-20 1979-12-18 Davis Frank F Non-immunogenic polypeptides
DE2360794C2 (de) * 1973-12-06 1984-12-06 Hoechst Ag, 6230 Frankfurt Verfahren zur Herstellung von Peptiden
US4200557A (en) * 1973-12-07 1980-04-29 Personal Products Company Absorbent product including grafted insolubilized cellulose ether
US3949073A (en) * 1974-11-18 1976-04-06 The Board Of Trustees Of Leland Stanford Junior University Process for augmenting connective mammalian tissue with in situ polymerizable native collagen solution
CH596313A5 (de) * 1975-05-30 1978-03-15 Battelle Memorial Institute
US4488911A (en) * 1975-10-22 1984-12-18 Luck Edward E Non-antigenic collagen and articles of manufacture
US4002531A (en) * 1976-01-22 1977-01-11 Pierce Chemical Company Modifying enzymes with polyethylene glycol and product produced thereby
NL7704659A (nl) * 1976-05-12 1977-11-15 Battelle Institut E V Beendervervangings-, beenderverbindings- of prothesenverankeringsmateriaal.
GB1578348A (en) * 1976-08-17 1980-11-05 Pharmacia Ab Products and a method for the therapeutic suppression of reaginic antibodies responsible for common allergic
DE2900110A1 (de) * 1979-01-03 1980-07-10 Wolff Walsrode Ag Loesliche makromolekularsubstanzen mit hohem dispergier-, suspendier- und fluessigkeitsrueckhaltevermoegen, verfahren zu ihrer herstellung und verwendung
JPS6023084B2 (ja) * 1979-07-11 1985-06-05 味の素株式会社 代用血液
CS216992B1 (en) * 1980-07-21 1982-12-31 Miroslav Stol Composite polymere material for the biological and medicinal utilitation and method of preparation thereof
US4314380A (en) * 1980-09-26 1982-02-09 Koken Co., Ltd. Artificial bone
US4415665A (en) * 1980-12-12 1983-11-15 Pharmacia Fine Chemicals Ab Method of covalently binding biologically active organic substances to polymeric substances
US4414147A (en) * 1981-04-17 1983-11-08 Massachusetts Institute Of Technology Methods of decreasing the hydrophobicity of fibroblast and other interferons
WO1982004260A1 (en) * 1981-05-25 1982-12-09 Anker Jarl Jacobsen A method for the recovery of petrol(gasoline)from a mixture of petrol vapour and air,and a system for use in the method
JPS57206622A (en) * 1981-06-10 1982-12-18 Ajinomoto Co Inc Blood substitute
US4451568A (en) * 1981-07-13 1984-05-29 Battelle Memorial Institute Composition for binding bioactive substances
US4388428A (en) * 1981-07-20 1983-06-14 National Patent Development Corporation Biologically stabilized compositions comprising collagen as the major component with ethylenically unsaturated compounds used as contact lenses
US4357274A (en) * 1981-08-06 1982-11-02 Intermedicat Gmbh Process for the manufacture of sclero protein transplants with increased biological stability
JPS5896026A (ja) * 1981-10-30 1983-06-07 Nippon Chemiphar Co Ltd 新規ウロキナ−ゼ誘導体およびその製造法ならびにそれを含有する血栓溶解剤
US4424208A (en) * 1982-01-11 1984-01-03 Collagen Corporation Collagen implant material and method for augmenting soft tissue
US4582640A (en) * 1982-03-08 1986-04-15 Collagen Corporation Injectable cross-linked collagen implant material
EP0098110B1 (de) * 1982-06-24 1989-10-18 NIHON CHEMICAL RESEARCH KABUSHIKI KAISHA also known as JAPAN CHEMICAL RESEARCH CO., LTD Zusammensetzung mit längerer Wirkung
US4737544A (en) * 1982-08-12 1988-04-12 Biospecific Technologies, Inc. Biospecific polymers
EP0105014B1 (de) * 1982-09-24 1992-05-20 THE UNITED STATES OF AMERICA as represented by the Secretary United States Department of Commerce Wiederherstellung von Gewebe bei Tieren
US4973493A (en) * 1982-09-29 1990-11-27 Bio-Metric Systems, Inc. Method of improving the biocompatibility of solid surfaces
US5059654A (en) * 1983-02-14 1991-10-22 Cuno Inc. Affinity matrices of modified polysaccharide supports
JPS6028936A (ja) * 1983-07-27 1985-02-14 Koken:Kk アテロコラ−ゲン水溶液およびその製造方法
US4500676A (en) * 1983-12-15 1985-02-19 Biomatrix, Inc. Hyaluronate modified polymeric articles
US4487865A (en) * 1983-12-15 1984-12-11 Biomatrix, Inc. Polymeric articles modified with hyaluronate
US4496689A (en) * 1983-12-27 1985-01-29 Miles Laboratories, Inc. Covalently attached complex of alpha-1-proteinase inhibitor with a water soluble polymer
JPS6145765A (ja) * 1984-08-07 1986-03-05 宇部興産株式会社 血管補綴物及びその製造方法
US4687820A (en) * 1984-08-22 1987-08-18 Cuno Incorporated Modified polypeptide supports
US4557764A (en) * 1984-09-05 1985-12-10 Collagen Corporation Process for preparing malleable collagen and the product thereof
US4888366A (en) * 1984-10-24 1989-12-19 Collagen Corporation Inductive collagen-based bone repair preparations
US4563350A (en) * 1984-10-24 1986-01-07 Collagen Corporation Inductive collagen based bone repair preparations
GB8430252D0 (en) * 1984-11-30 1985-01-09 Beecham Group Plc Compounds
US4600533A (en) * 1984-12-24 1986-07-15 Collagen Corporation Collagen membranes for medical use
US4732863A (en) * 1984-12-31 1988-03-22 University Of New Mexico PEG-modified antibody with reduced affinity for cell surface Fc receptors
US4636526A (en) * 1985-02-19 1987-01-13 The Dow Chemical Company Composites of unsintered calcium phosphates and synthetic biodegradable polymers useful as hard tissue prosthetics
US4642117A (en) * 1985-03-22 1987-02-10 Collagen Corporation Mechanically sheared collagen implant material and method
DE3521684A1 (de) * 1985-06-18 1986-12-18 Dr. Müller-Lierheim KG, Biologische Laboratorien, 8033 Planegg Verfahren zur beschichtung von polymeren
US4766106A (en) * 1985-06-26 1988-08-23 Cetus Corporation Solubilization of proteins for pharmaceutical compositions using polymer conjugation
JPS63502354A (ja) * 1986-01-06 1988-09-08 ザ　ユニヴァーシティ　オブ　メルボルン コラ−ゲン生産物
WO1987004478A1 (en) * 1986-01-23 1987-07-30 Ipa-Isorast International S.A. Securing element for cased concrete structures
CA1283046C (en) * 1986-05-29 1991-04-16 Nandini Katre Tumor necrosis factor formulation
US4745180A (en) * 1986-06-27 1988-05-17 Cetus Corporation Solubilization of proteins for pharmaceutical compositions using heparin fragments
US4979959A (en) * 1986-10-17 1990-12-25 Bio-Metric Systems, Inc. Biocompatible coating for solid surfaces
US4847325A (en) * 1988-01-20 1989-07-11 Cetus Corporation Conjugation of polymer to colony stimulating factor-1
ATA255988A (de) * 1988-10-14 1993-05-15 Chemie Linz Gmbh Absorbierendes polymerisat
US5162430A (en) * 1988-11-21 1992-11-10 Collagen Corporation Collagen-polymer conjugates
US5201764A (en) * 1990-02-28 1993-04-13 Autogenesis Technologies, Inc. Biologically compatible collagenous reaction product and articles useful as medical implants produced therefrom
JP3008034B2 (ja) * 1990-04-23 2000-02-14 株式会社高研 体内注入可能な高濃度架橋化アテロコラ−ゲン移植用組成物
WO1992004048A2 (en) * 1990-08-30 1992-03-19 The Biomembrane Institute Inhibition of metastasis potential and invasiveness by oligosaccharides or oligosaccharide antigens or antibodies

Also Published As

Publication number Publication date
EP0444157A1 (de) 1991-09-04
JPH04502027A (ja) 1992-04-09
US5446091A (en) 1995-08-29
EP0444157B1 (de) 1998-07-22
US5550188A (en) 1996-08-27
EP0444157A4 (en) 1991-11-13
ES2119743T3 (es) 1998-10-16
US5308889A (en) 1994-05-03
CA2003538C (en) 2001-02-06
US5413791A (en) 1995-05-09
CA2003538A1 (en) 1990-05-21
AU4660989A (en) 1990-06-12
ATE168708T1 (de) 1998-08-15
US5324775A (en) 1994-06-28
DE68928754T2 (de) 1999-01-14
JP2505312B2 (ja) 1996-06-05
US5162430A (en) 1992-11-10
AU638687B2 (en) 1993-07-08
US5292802A (en) 1994-03-08
US5328955A (en) 1994-07-12
WO1990005755A1 (en) 1990-05-31

Similar Documents

Publication Publication Date Title
DE68928754D1 (de) Kollagen-polymer-konjugate
AU2352288A (en) Biodegradable implant
EP0895785A3 (de) Füllmaterial für implantierbare Prothesen aus Weichgewebe und Implantate daraus
DE69705746T2 (de) Injizierbare depotgelzubereitung und herstellungsverfahren
ME00880B (me) Inkluzioni kompleks aril-heterocikličnih soli
DK178583A (da) Praeparater med loebende frigoerelse
ATE121435T1 (de) Zur hautpflege verwendbare polymermischungen.
NO884660D0 (no) Nedbrytbare kunststoffblandinger.
AU697005B2 (en) Implantable molded articles for the administration of active substances to plants
HK1019005A1 (en) Synthetic viscoelastic material for physiological applications such as for ophthalmic applications
GR3019344T3 (en) Polymer blends for aqueous dispersions having improved freeze-thaw stability
EP1080724A4 (de) Zusammenstellung die die mpt-aktivität mindert
AU2804395A (en) Long-acting oxytetracycline composition
FI945917A (fi) Biologisesti hajoava säiliö keräystä tai kuljetusta varten
ATE273684T1 (de) Eingekapselte wasserdispergierbare perfluoroetherpolymere
RU98109421A (ru) Протезы кровеносных сосудов

Legal Events

Date Code Title Description
8327 Change in the person/name/address of the patent owner

Owner name: COHESION TECHNOLOGIES, INC., PALO ALTO, CALIF., US

8364 No opposition during term of opposition
8327 Change in the person/name/address of the patent owner

Owner name: ANGIOTECH BIOMATERIALS CORP.(N.D.GES.D.STAATES DEL

8327 Change in the person/name/address of the patent owner

Owner name: ANGIODEVICE INTERNATIONAL GMBH, ZUG, CH

8339 Ceased/non-payment of the annual fee