DE69011399D1 - Stabile flüssige Formulierung von 5-Aminosalizylsäure. - Google Patents

Stabile flüssige Formulierung von 5-Aminosalizylsäure.

Info

Publication number
DE69011399D1
DE69011399D1 DE69011399T DE69011399T DE69011399D1 DE 69011399 D1 DE69011399 D1 DE 69011399D1 DE 69011399 T DE69011399 T DE 69011399T DE 69011399 T DE69011399 T DE 69011399T DE 69011399 D1 DE69011399 D1 DE 69011399D1
Authority
DE
Germany
Prior art keywords
alkali
aminosalicylic acid
asa
solution
alkaline earth
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69011399T
Other languages
English (en)
Other versions
DE69011399T2 (de
Inventor
Carey B Bottom
Margaret N Kwoka
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Aventis Pharmaceuticals Inc
Original Assignee
Marion Merrell Dow Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Marion Merrell Dow Inc filed Critical Marion Merrell Dow Inc
Application granted granted Critical
Publication of DE69011399D1 publication Critical patent/DE69011399D1/de
Publication of DE69011399T2 publication Critical patent/DE69011399T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/60—Salicylic acid; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/02—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0031—Rectum, anus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A61K47/186—Quaternary ammonium compounds, e.g. benzalkonium chloride or cetrimide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/22—Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
DE69011399T 1989-05-15 1990-05-14 Stabile flüssige Formulierung von 5-Aminosalizylsäure. Expired - Fee Related DE69011399T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/352,064 US5010069A (en) 1989-05-15 1989-05-15 Stable liquid form of 5-aminosalicylic acid

Publications (2)

Publication Number Publication Date
DE69011399D1 true DE69011399D1 (de) 1994-09-15
DE69011399T2 DE69011399T2 (de) 1994-12-15

Family

ID=23383642

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69011399T Expired - Fee Related DE69011399T2 (de) 1989-05-15 1990-05-14 Stabile flüssige Formulierung von 5-Aminosalizylsäure.

Country Status (8)

Country Link
US (1) US5010069A (de)
EP (1) EP0398207B1 (de)
JP (1) JPH0347161A (de)
AT (1) ATE109660T1 (de)
CA (1) CA2016825A1 (de)
DE (1) DE69011399T2 (de)
DK (1) DK0398207T3 (de)
ES (1) ES2062161T3 (de)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1992016214A1 (en) * 1991-03-15 1992-10-01 Norwich Eaton Pharmaceuticals Inc. The use of 5-aminosalicylic acid in the treatment of irritable bowel syndrome - diarrheal phase or type (ibs-d)
EP0586488B1 (de) * 1991-06-07 1995-05-03 Byk Gulden Lomberg Chemische Fabrik GmbH Pharmazeutische klistierzubereitung
FR2738150B1 (fr) * 1995-09-01 1997-10-31 Synthelabo Utilisation de la sulphasalazine et de ses metabolites pour la fabrication d'un medicament utile dans le traitement de l'insuffisance veineuse et des ulceres veineux
IT1277663B1 (it) * 1995-09-28 1997-11-11 Crinos Industria Farmaco Sospensioni acquose stabili di mesalazina per uso topico
US6326364B1 (en) 1999-02-08 2001-12-04 Cedars-Sinai Medical Center Use of 5-aminosalicylates as antimicrobial agents
EP1642885B1 (de) 2000-08-29 2009-11-11 Biocon Limited Verwendung einer pharmazeutischen Zusammensetzung mit einem Para-Aminophenylessigsäurederivat für die Behandlung von entzündlichen Erkrankungen des Magen-Darmtrakts
JP3805646B2 (ja) * 2001-05-25 2006-08-02 久光メディカル株式会社 医薬液剤
US8048924B2 (en) * 2001-08-29 2011-11-01 Biocon Limited Methods and compositions employing 4-aminophenylacetic acid compounds
US20040087527A1 (en) * 2002-10-31 2004-05-06 Day Brian J. Methods for treatment of thiol-containing compound deficient conditions
KR20060090667A (ko) * 2003-09-22 2006-08-14 닛신 쿄린 세이야꾸 가부시끼가이샤 변색 개선된 5-아미노살리실산 고형 제제 및 그의 보존방법
WO2005072113A2 (en) * 2004-01-20 2005-08-11 Harty Richard F Compositions and methods of treatment for inflammatory diseases
DK1773767T3 (en) 2004-07-07 2016-03-21 Biocon Ltd Synthesis of azo bound in immune regulatory relations
US7645801B2 (en) * 2007-01-29 2010-01-12 Alaven Pharmaceutical Llc Reduced irritant enema for treatment of inflammatory bowel disease (IBD)
KR101420315B1 (ko) 2014-03-19 2014-07-17 남봉길 약학적 액제 조성물
US20160263152A1 (en) * 2015-03-14 2016-09-15 Gavis Pharmaceuticals Bowel cleansing composition with improved taste
WO2018009761A1 (en) * 2016-07-08 2018-01-11 Ferring B.V. Stabilized liquid formulations containing picosulfate
CN113350277A (zh) * 2021-06-30 2021-09-07 广东科伦药业有限公司 一种治疗化疗口腔黏膜炎的美沙拉秦含漱液及其制备方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2647853A (en) * 1949-11-29 1953-08-04 Lab Francais Chimiotherapie Injectable solution of salt of para-aminosalicylic acid
JPS57500432A (de) * 1980-03-20 1982-03-11
DE3151196A1 (de) * 1981-12-23 1983-06-30 Kurt Heinz Prof. Dr. 7800 Freiburg Bauer Verfahren zur herstellung von gut loeslichen 5-aminosalicylsaeure-arzneimittelzubereitungen
US4664256A (en) * 1983-09-06 1987-05-12 Farmaceutisk Laboratorium Ferring A/S Packaged stable enema solution or suspension containing 5-aminosalicyclic acid
US4657900A (en) * 1983-09-27 1987-04-14 Rowell Laboratories Pharmaceutical article of manufacture comprising a bisulfite stabilized aqueous solution of 5-aminosalicylic acid and method
DK536987A (da) * 1987-10-14 1989-04-15 Ferring Farma Lab Anvendelse af 5-aminosalicylsyre (5-asa) til fremstilling af et farmaceutisk praeparat til anvendelse ved reperfusionsbehandling

Also Published As

Publication number Publication date
DK0398207T3 (da) 1994-10-03
EP0398207A1 (de) 1990-11-22
CA2016825A1 (en) 1990-11-15
DE69011399T2 (de) 1994-12-15
EP0398207B1 (de) 1994-08-10
JPH0347161A (ja) 1991-02-28
ES2062161T3 (es) 1994-12-16
ATE109660T1 (de) 1994-08-15
US5010069A (en) 1991-04-23

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee