DE69109109T2 - Ubiquitinspezifische protease. - Google Patents
Ubiquitinspezifische protease.Info
- Publication number
- DE69109109T2 DE69109109T2 DE69109109T DE69109109T DE69109109T2 DE 69109109 T2 DE69109109 T2 DE 69109109T2 DE 69109109 T DE69109109 T DE 69109109T DE 69109109 T DE69109109 T DE 69109109T DE 69109109 T2 DE69109109 T2 DE 69109109T2
- Authority
- DE
- Germany
- Prior art keywords
- ubiquitin
- peptide
- protease
- protein
- moiety
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 108091005804 Peptidases Proteins 0.000 title abstract 5
- 239000004365 Protease Substances 0.000 title abstract 5
- 102100037486 Reverse transcriptase/ribonuclease H Human genes 0.000 title abstract 5
- 102000044159 Ubiquitin Human genes 0.000 abstract 9
- 108090000848 Ubiquitin Proteins 0.000 abstract 9
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 6
- 108090000623 proteins and genes Proteins 0.000 abstract 6
- 102000004169 proteins and genes Human genes 0.000 abstract 5
- 102000018390 Ubiquitin-Specific Proteases Human genes 0.000 abstract 3
- 108010066496 Ubiquitin-Specific Proteases Proteins 0.000 abstract 3
- 230000004927 fusion Effects 0.000 abstract 3
- 108091028043 Nucleic acid sequence Proteins 0.000 abstract 1
- 125000000539 amino acid group Chemical group 0.000 abstract 1
- 230000009504 deubiquitination Effects 0.000 abstract 1
- 239000013604 expression vector Substances 0.000 abstract 1
- 230000005714 functional activity Effects 0.000 abstract 1
- 238000000338 in vitro Methods 0.000 abstract 1
- 238000001727 in vivo Methods 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 239000003607 modifier Substances 0.000 abstract 1
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 1
- 238000003259 recombinant expression Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/62—DNA sequences coding for fusion proteins
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/58—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from fungi
- C12N9/60—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from fungi from yeast
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/95—Fusion polypeptide containing a motif/fusion for degradation (ubiquitin fusions, PEST sequence)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US52108990A | 1990-05-09 | 1990-05-09 | |
US57395890A | 1990-08-28 | 1990-08-28 | |
PCT/US1991/003177 WO1991017245A1 (en) | 1990-05-09 | 1991-05-08 | Ubiquitin-specific protease |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69109109D1 DE69109109D1 (de) | 1995-05-24 |
DE69109109T2 true DE69109109T2 (de) | 1995-09-14 |
Family
ID=27060368
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69109109T Expired - Fee Related DE69109109T2 (de) | 1990-05-09 | 1991-05-08 | Ubiquitinspezifische protease. |
Country Status (9)
Country | Link |
---|---|
US (1) | US5391490A (de) |
EP (1) | EP0531404B1 (de) |
JP (1) | JP3041644B2 (de) |
AT (1) | ATE121454T1 (de) |
CA (1) | CA2079229C (de) |
DE (1) | DE69109109T2 (de) |
DK (1) | DK0531404T3 (de) |
ES (1) | ES2071315T3 (de) |
WO (1) | WO1991017245A1 (de) |
Families Citing this family (28)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5212058A (en) * | 1990-05-09 | 1993-05-18 | Massachusetts Institute Of Technology | Nucleic acid encoding ubiquitin-specific proteases |
US5744343A (en) * | 1994-01-04 | 1998-04-28 | Mitotix, Inc. | Ubiquitin conjugating enzymes |
EP0738394B1 (de) * | 1994-01-04 | 2000-05-17 | Mitotix, Inc. | Ubiquitin-konjugierende enzyme |
US5981699A (en) * | 1994-01-04 | 1999-11-09 | Mitotix, Inc. | Human ubiquitin conjugating enzyme |
WO1997006247A2 (en) | 1995-08-09 | 1997-02-20 | Dana Farber Cancer Institute | Deubiquitinating enzymes that regulate cell growth |
US5770720A (en) * | 1995-08-30 | 1998-06-23 | Barnes-Jewish Hospital | Ubiquitin conjugating enzymes having transcriptional repressor activity |
US6001619A (en) * | 1995-10-04 | 1999-12-14 | Cold Spring Harbor Laboratory | Ubiquitin ligases, and uses related thereto |
US5861483A (en) | 1996-04-03 | 1999-01-19 | Pro-Neuron, Inc. | Inhibitor of stem cell proliferation and uses thereof |
GB9618960D0 (en) | 1996-09-11 | 1996-10-23 | Medical Science Sys Inc | Proteases |
US6747128B2 (en) | 1997-08-20 | 2004-06-08 | Gpc Biotech, Inc. | Components of ubiquitin ligase complexes, and uses related thereto |
US5932422A (en) * | 1997-11-14 | 1999-08-03 | Millennium Pharmaceuticals, Inc. | Modulation of drug resistance via ubiquitin carboxy-terminal hydrolase |
US7332275B2 (en) * | 1999-10-13 | 2008-02-19 | Sequenom, Inc. | Methods for detecting methylated nucleotides |
US7070947B2 (en) * | 2000-02-29 | 2006-07-04 | Millennium Pharmaceuticals, Inc. | Human protein kinase, phosphatase, and protease family members and uses thereof |
WO2001066763A2 (en) * | 2000-03-07 | 2001-09-13 | Millennium Pharmaceuticals, Inc. | 23436, a human ubiquitin protease family member and uses thereof |
CN100390281C (zh) | 2000-06-15 | 2008-05-28 | 史密丝克莱恩比彻姆公司 | 制备具有生理活性的il-18多肽的方法 |
AU2001272491A1 (en) * | 2000-06-26 | 2002-01-08 | Smithkline Beecham Biologicals (S.A.) | Triple fusion proteins comprising ubiquitin fused between thioredoxin and a polypeptide of interest |
US7122332B2 (en) * | 2001-03-29 | 2006-10-17 | Rigel Pharmaceuticals, Inc. | Modulators of leukocyte activation, compositions and methods of use |
CN1774511B (zh) * | 2002-11-27 | 2013-08-21 | 斯昆诺有限公司 | 用于序列变异检测和发现的基于断裂的方法和系统 |
AU2004235331B2 (en) * | 2003-04-25 | 2008-12-18 | Sequenom, Inc. | Fragmentation-based methods and systems for De Novo sequencing |
US9394565B2 (en) * | 2003-09-05 | 2016-07-19 | Agena Bioscience, Inc. | Allele-specific sequence variation analysis |
US7608394B2 (en) | 2004-03-26 | 2009-10-27 | Sequenom, Inc. | Methods and compositions for phenotype identification based on nucleic acid methylation |
EP1727911B1 (de) | 2004-03-26 | 2013-01-23 | Sequenom, Inc. | Basenspezifische spaltung methylierungsspezifischer amplifikationsprodukte in kombination mit massenanalyse |
AU2005284980A1 (en) * | 2004-09-10 | 2006-03-23 | Sequenom, Inc. | Methods for long-range sequence analysis of nucleic acids |
US8158382B2 (en) | 2005-01-10 | 2012-04-17 | Instytut Biotechnologii I Antybiotykow | UBP1 protease mutant and its coding sequence, their applications and heterogonous protein expression system |
US8173792B2 (en) | 2007-02-09 | 2012-05-08 | The Board Of Trustees Of The Leland Stanford Junior University | Method for regulating protein function in cells using synthetic small molecules |
AU2008240143B2 (en) * | 2007-04-13 | 2013-10-03 | Agena Bioscience, Inc. | Comparative sequence analysis processes and systems |
US8530636B2 (en) | 2008-05-07 | 2013-09-10 | The Board Of Trustees Of The Leland Stanford Junior University | Method for regulating protein function in cells in vivo using synthetic small molecules |
WO2019173462A1 (en) * | 2018-03-06 | 2019-09-12 | Pepvax, Inc. | Nucleic acid molecules and methods of using the same |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2612874B2 (ja) * | 1986-10-02 | 1997-05-21 | マサチユセツツ・インスチチユート・オブ・テクノロジー | タンパク質の代謝的安定性を調節する方法 |
US5108919A (en) * | 1988-06-24 | 1992-04-28 | Genentech, Inc. | Dna sequences encoding yeast ubiquitin hydrolase |
-
1991
- 1991-05-08 ES ES91910453T patent/ES2071315T3/es not_active Expired - Lifetime
- 1991-05-08 DK DK91910453.9T patent/DK0531404T3/da active
- 1991-05-08 CA CA002079229A patent/CA2079229C/en not_active Expired - Fee Related
- 1991-05-08 JP JP3509978A patent/JP3041644B2/ja not_active Expired - Fee Related
- 1991-05-08 WO PCT/US1991/003177 patent/WO1991017245A1/en active IP Right Grant
- 1991-05-08 EP EP91910453A patent/EP0531404B1/de not_active Expired - Lifetime
- 1991-05-08 AT AT91910453T patent/ATE121454T1/de not_active IP Right Cessation
- 1991-05-08 DE DE69109109T patent/DE69109109T2/de not_active Expired - Fee Related
-
1994
- 1994-01-25 US US08/186,434 patent/US5391490A/en not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
EP0531404B1 (de) | 1995-04-19 |
ATE121454T1 (de) | 1995-05-15 |
DK0531404T3 (da) | 1995-09-18 |
ES2071315T3 (es) | 1995-06-16 |
JPH06500006A (ja) | 1994-01-06 |
WO1991017245A1 (en) | 1991-11-14 |
US5391490A (en) | 1995-02-21 |
EP0531404A1 (de) | 1993-03-17 |
JP3041644B2 (ja) | 2000-05-15 |
DE69109109D1 (de) | 1995-05-24 |
CA2079229C (en) | 1999-09-14 |
CA2079229A1 (en) | 1991-11-10 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition | ||
8339 | Ceased/non-payment of the annual fee |