DE69109282T2 - Verfahren zum geschmacksabdecken von ibuprofen. - Google Patents

Verfahren zum geschmacksabdecken von ibuprofen.

Info

Publication number
DE69109282T2
DE69109282T2 DE69109282T DE69109282T DE69109282T2 DE 69109282 T2 DE69109282 T2 DE 69109282T2 DE 69109282 T DE69109282 T DE 69109282T DE 69109282 T DE69109282 T DE 69109282T DE 69109282 T2 DE69109282 T2 DE 69109282T2
Authority
DE
Germany
Prior art keywords
ibuprofen
flavoring
controlled release
release characteristics
ibuprofen tablet
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69109282T
Other languages
English (en)
Other versions
DE69109282D1 (de
Inventor
Robert Shen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pharmacia and Upjohn Co
Original Assignee
Upjohn Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Upjohn Co filed Critical Upjohn Co
Publication of DE69109282D1 publication Critical patent/DE69109282D1/de
Application granted granted Critical
Publication of DE69109282T2 publication Critical patent/DE69109282T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2077—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets
    • A61K9/2081—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets with microcapsules or coated microparticles according to A61K9/50
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5026—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pain & Pain Management (AREA)
  • Organic Chemistry (AREA)
  • Physiology (AREA)
  • Nutrition Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Zoology (AREA)
  • Rheumatology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DE69109282T 1990-04-11 1991-02-26 Verfahren zum geschmacksabdecken von ibuprofen. Expired - Fee Related DE69109282T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US50819390A 1990-04-11 1990-04-11
PCT/US1991/001089 WO1991015194A1 (en) 1990-04-11 1991-02-26 Taste masking of ibuprofen by fluid bed coating

Publications (2)

Publication Number Publication Date
DE69109282D1 DE69109282D1 (de) 1995-06-01
DE69109282T2 true DE69109282T2 (de) 1995-09-28

Family

ID=24021750

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69109282T Expired - Fee Related DE69109282T2 (de) 1990-04-11 1991-02-26 Verfahren zum geschmacksabdecken von ibuprofen.

Country Status (14)

Country Link
US (1) US5552152A (de)
EP (1) EP0524180B1 (de)
JP (1) JPH05506011A (de)
AT (1) ATE121619T1 (de)
AU (1) AU639988B2 (de)
CA (1) CA2076983A1 (de)
DE (1) DE69109282T2 (de)
DK (1) DK0524180T3 (de)
ES (1) ES2071986T3 (de)
FI (1) FI924589A (de)
HU (2) HUT64220A (de)
NO (1) NO300758B1 (de)
RU (1) RU2101010C1 (de)
WO (1) WO1991015194A1 (de)

Families Citing this family (49)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19648576C2 (de) * 1996-11-23 1999-08-12 Lohmann Therapie Syst Lts Lutschtablette zur modifizierten Freisetzung von Wirkstoffen im Gastrointestinaltrakt
FR2766089B1 (fr) * 1997-07-21 2000-06-02 Prographarm Lab Comprime multiparticulaire perfectionne a delitement rapide
CH693954A5 (de) * 1997-11-12 2004-05-14 Bayer Ag 2-Phenyl-substituierte Imidazotriazinone als Phosphodiesterase Inhibitoren.
FR2785538B1 (fr) * 1998-11-06 2004-04-09 Prographarm Laboratoires Comprime a delitement rapide perfectionne
FR2785539B1 (fr) 1998-11-06 2004-04-09 Prographarm Laboratoires Particules enrobees d'ibuprofene cristallin granule
US6270807B1 (en) 1999-03-02 2001-08-07 L. Perrigo Company Taste-masked pharmaceutical composition
WO2000059467A1 (fr) 1999-04-06 2000-10-12 Laboratoires Des Produits Ethiques Ethypharm Suspension pharmaceutique buvable d'ibuprofene
TR200200313T2 (tr) 1999-08-17 2002-04-22 Novartis Consumer Health S.A. Hızla çözünen dozaj formu ve bunun yapım prosesi.
BR0016236A (pt) 1999-12-09 2002-12-24 Boots Co Plc Agentes terapêuticos
US6551617B1 (en) 2000-04-20 2003-04-22 Bristol-Myers Squibb Company Taste masking coating composition
EP1276470B1 (de) 2000-04-20 2007-05-02 Novartis AG Beschichtungszusammensetzung zur geschmacksmaskierung
WO2002089808A1 (de) * 2001-05-09 2002-11-14 Bayer Healthcare Ag Neue verwendung von 2-phenyl-substituierten imidazotriazinonen
AU2002327418A1 (en) * 2001-08-01 2003-02-17 Bristol-Myers Squibb Company Taste masking composition
US20190328679A1 (en) 2001-10-12 2019-10-31 Aquestive Therapeutics, Inc. Uniform films for rapid-dissolve dosage form incorporating anti-tacking compositions
US7357891B2 (en) 2001-10-12 2008-04-15 Monosol Rx, Llc Process for making an ingestible film
US8765167B2 (en) 2001-10-12 2014-07-01 Monosol Rx, Llc Uniform films for rapid-dissolve dosage form incorporating anti-tacking compositions
US20110033542A1 (en) 2009-08-07 2011-02-10 Monosol Rx, Llc Sublingual and buccal film compositions
US10285910B2 (en) 2001-10-12 2019-05-14 Aquestive Therapeutics, Inc. Sublingual and buccal film compositions
US8603514B2 (en) 2002-04-11 2013-12-10 Monosol Rx, Llc Uniform films for rapid dissolve dosage form incorporating taste-masking compositions
US11207805B2 (en) 2001-10-12 2021-12-28 Aquestive Therapeutics, Inc. Process for manufacturing a resulting pharmaceutical film
JP5069395B2 (ja) 2002-02-21 2012-11-07 ヴァレアント インターナショナル （バルバドス） エスアールエル トラマドールの少なくとも１つの形の放出が改良された医薬組成物
CO5400144A1 (es) 2002-03-11 2004-05-31 Novartis Ag Compuestos organicos
DE10232113A1 (de) * 2002-07-16 2004-01-29 Bayer Ag Vardenafil Hydrochlorid Trihydrat enthaltende Arzneimittel
FR2850275B1 (fr) 2003-01-24 2005-04-08 Scherer Technologies Inc R P Capsules molles a macher contenant une substance active a gout masque
JP2007031281A (ja) * 2003-06-25 2007-02-08 Kowa Co イブプロフェン含有フィルムコーティング錠剤
US20050220825A1 (en) * 2004-03-10 2005-10-06 Adrian Funke Molecular dispersions of drospirenone
DE102004023069A1 (de) * 2004-05-11 2005-12-08 Bayer Healthcare Ag Neue Darreichungsformen des PDE 5-Inhibitors Vardenafil
DE102005001989A1 (de) * 2005-01-15 2006-07-20 Bayer Healthcare Ag Intravenöse Formulierungen von PDE-Inhibitoren
DE102005009241A1 (de) * 2005-03-01 2006-09-07 Bayer Healthcare Ag Arzneiformen mit kontrollierter Bioverfügbarkeit
DE102005009240A1 (de) * 2005-03-01 2006-09-07 Bayer Healthcare Ag Arzneiformen mit verbesserten pharmakokinetischen Eigenschaften
AU2006299232A1 (en) * 2005-09-29 2007-04-12 Bayer Schering Pharma Aktiengesellschaft PDE inhibitors and combinations thereof for the treatment of urological disorders
US20070134493A1 (en) * 2005-12-08 2007-06-14 Kanji Meghpara Compositions and capsules with stable hydrophilic layers
US7767248B2 (en) 2007-02-02 2010-08-03 Overly Iii Harry J Soft chew confectionary with high fiber and sugar content and method for making same
US20100184769A1 (en) * 2007-06-13 2010-07-22 Bayer Schering Pharma Aktiengesellschaft Pde inhibitors for the treatment of hearing impairment
US8404275B2 (en) 2007-07-01 2013-03-26 Vitalis Llc Combination tablet with chewable outer layer
WO2009005803A1 (en) * 2007-07-01 2009-01-08 Joseph Peter Habboushe Combination tablet with chewable outer layer
ES2363964B1 (es) 2009-11-20 2012-08-22 Gp Pharm, S.A. Cápsulas de principios activos farmacéuticos y ésteres de ácidos grasos poliinsaturados.
US9149959B2 (en) 2010-10-22 2015-10-06 Monosol Rx, Llc Manufacturing of small film strips
CN107296798A (zh) 2011-10-28 2017-10-27 维塔利斯公司 抗发红组合物
PT2833880T (pt) * 2012-04-02 2017-12-06 Pharma Seeds Create Llc Composição de dosagem oral sólida de ibuprofeno compreendendo um copolímero de ácido metacrílico
US8993041B2 (en) 2012-10-15 2015-03-31 New Jersey Institute Of Technology Taste masked active pharmaceutical powder compositions and processes for making them
WO2014194872A1 (en) 2013-06-04 2014-12-11 Zentiva, K.S. Taste masking of water soluble drugs using poloxamers
RU2576236C1 (ru) * 2014-08-22 2016-02-27 Александр Александрович Кролевец Способ получения нанокапсул антибиотиков в агар-агаре
RU2577689C1 (ru) * 2014-08-26 2016-03-20 Александр Александрович Кролевец Способ получения нанокапсул антибиотиков в агар-агаре
RU2578408C1 (ru) * 2014-09-10 2016-03-27 Александр Александрович Кролевец Способ получения нанокапсул алкалоидов
US11273131B2 (en) 2016-05-05 2022-03-15 Aquestive Therapeutics, Inc. Pharmaceutical compositions with enhanced permeation
BR112018072539A2 (pt) 2016-05-05 2019-03-26 Aquestive Therapeutics, Inc. composições de epinefrina de administração aumentada
RU2688148C1 (ru) * 2016-05-10 2019-05-20 Александр Александрович Кролевец Способ получения нанокапсул экоцида в каррагинане
CN110917165A (zh) * 2019-12-26 2020-03-27 北京鑫开元医药科技有限公司海南分公司 一种布洛芬口崩片及其制备方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB971700A (en) * 1961-02-02 1964-09-30 Boots Pure Drug Co Ltd Anti-Inflammatory Agents
US4476248A (en) * 1983-02-28 1984-10-09 The Upjohn Company Crystallization of ibuprofen
US4609675A (en) * 1984-08-17 1986-09-02 The Upjohn Company Stable, high dose, high bulk density ibuprofen granulations for tablet and capsule manufacturing
DE3678644D1 (de) * 1985-08-16 1991-05-16 Procter & Gamble Wirkstoffpartikel mit sowohl kontinuierlicher als auch schneller freisetzung.
IT1214629B (it) * 1985-08-29 1990-01-18 Formenti Farmaceutici Spa Procedimento di microincapsulazione di un medicamento,medicamento cosi'preparato,e composizioni farmaceutiche che lo comprendono
US4800087A (en) * 1986-11-24 1989-01-24 Mehta Atul M Taste-masked pharmaceutical compositions
US4835186A (en) * 1987-06-15 1989-05-30 American Home Products Corporation Spray dried ibuprofen
US5084278A (en) * 1989-06-02 1992-01-28 Nortec Development Associates, Inc. Taste-masked pharmaceutical compositions

Also Published As

Publication number Publication date
FI924589A0 (fi) 1992-10-09
DE69109282D1 (de) 1995-06-01
HU9203193D0 (en) 1992-12-28
ATE121619T1 (de) 1995-05-15
NO923947L (no) 1992-10-09
EP0524180A1 (de) 1993-01-27
NO923947D0 (no) 1992-10-09
DK0524180T3 (da) 1995-09-04
ES2071986T3 (es) 1995-07-01
JPH05506011A (ja) 1993-09-02
CA2076983A1 (en) 1991-10-12
FI924589A (fi) 1992-10-09
WO1991015194A1 (en) 1991-10-17
US5552152A (en) 1996-09-03
EP0524180B1 (de) 1995-04-26
HU211247A9 (en) 1995-11-28
HUT64220A (en) 1993-12-28
AU7256091A (en) 1991-10-30
AU639988B2 (en) 1993-08-12
RU2101010C1 (ru) 1998-01-10
NO300758B1 (no) 1997-07-21

Similar Documents

Publication Publication Date Title
DE69109282T2 (de) Verfahren zum geschmacksabdecken von ibuprofen.
DE69106001D1 (de) Vorrichtung zum automatischen einleiten von herzkammerflimmern.
DE69120665T2 (de) Selbsttätige vorrichtung zum verbinden von bahnen
DE58900516D1 (de) Verfahren zum pelletieren.
DE3889831D1 (de) Laser-Apparat.
DE3866017D1 (de) Vorrichtung zum hydraulischen aufweiten.
DE3768057D1 (de) Vorrichtung zum reproduzieren.
DE59102032D1 (de) Vorrichtung zum übertragen von laserlicht.
DE3874405D1 (de) Vorrichtung zum unterscheiden von bildbereichen.
DE3879547D1 (de) Laser-apparat.
DE3854236T2 (de) Laser-Apparat.
DE3773856D1 (de) Verfahren zum eindampfen fotografischer ablaugen.
DE3773869D1 (de) Verfahren zum eindampfen fotografischer ablaugen.
DE3884275T2 (de) Vorrichtung zum Entfernen von Haspeln.
DE58901568D1 (de) Verfahren zum aufnehmen einzelner flaechiger gebilde.
DE58901845D1 (de) Verfahren zum festlegen.
DE69007286T2 (de) Verfahren zum fotografischen verfahren.
DE3878358D1 (de) Vorrichtung zum seitlichen spurenthalten von bahnen.
DE68905163D1 (de) Verfahren zum sterilisieren.
DE68914094D1 (de) Immunoanalyseverfahren.
DE3854168D1 (de) Vorrichtung zum automatischen Komponieren.
DE3873778D1 (de) Vorrichtung zum schwalloeten.
DE68901139D1 (de) Verfahren zum herstellen einer photokathode fuer einen bildverstaerker.
DE3867911D1 (de) Vorrichtung zum anfeuchten von klebstoffbeschichteten etiketten.
PT99126A (pt) Metodo para a reproducao de arvores mediante utilizacao de marcadores moleculares

Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee