DE69116126T2 - Bildgebender Durchflusszytometer - Google Patents

Bildgebender Durchflusszytometer

Info

Publication number
DE69116126T2
DE69116126T2 DE69116126T DE69116126T DE69116126T2 DE 69116126 T2 DE69116126 T2 DE 69116126T2 DE 69116126 T DE69116126 T DE 69116126T DE 69116126 T DE69116126 T DE 69116126T DE 69116126 T2 DE69116126 T2 DE 69116126T2
Authority
DE
Germany
Prior art keywords
flow cytometer
imaging flow
imaging
cytometer
flow
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69116126T
Other languages
English (en)
Other versions
DE69116126D1 (de
Inventor
Yasunori Maekawa
Tokihiro Kosaka
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sysmex Corp
Original Assignee
Sysmex Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sysmex Corp filed Critical Sysmex Corp
Publication of DE69116126D1 publication Critical patent/DE69116126D1/de
Application granted granted Critical
Publication of DE69116126T2 publication Critical patent/DE69116126T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume, or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Electro-optical investigation, e.g. flow cytometers
    • G01N15/1425—Electro-optical investigation, e.g. flow cytometers using an analyser being characterised by its control arrangement
    • G01N15/1427—Electro-optical investigation, e.g. flow cytometers using an analyser being characterised by its control arrangement with the synchronisation of components, a time gate for operation of components, or suppression of particle coincidences
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume, or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Electro-optical investigation, e.g. flow cytometers
    • G01N15/1429—Electro-optical investigation, e.g. flow cytometers using an analyser being characterised by its signal processing
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume, or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Electro-optical investigation, e.g. flow cytometers
    • G01N15/1456—Electro-optical investigation, e.g. flow cytometers without spatial resolution of the texture or inner structure of the particle, e.g. processing of pulse signals
    • G01N15/1459—Electro-optical investigation, e.g. flow cytometers without spatial resolution of the texture or inner structure of the particle, e.g. processing of pulse signals the analysis being performed on a sample stream
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume, or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Electro-optical investigation, e.g. flow cytometers
    • G01N15/1434—Electro-optical investigation, e.g. flow cytometers using an analyser being characterised by its optical arrangement
    • G01N2015/144—Imaging characterised by its optical setup
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N2021/1789—Time resolved
    • G01N2021/1791—Time resolved stroboscopic; pulse gated; time range gated
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/645—Specially adapted constructive features of fluorimeters
    • G01N21/6456—Spatial resolved fluorescence measurements; Imaging
DE69116126T 1991-02-27 1991-09-05 Bildgebender Durchflusszytometer Expired - Fee Related DE69116126T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP03033138A JP3084295B2 (ja) 1991-02-27 1991-02-27 フローイメージサイトメータ

Publications (2)

Publication Number Publication Date
DE69116126D1 DE69116126D1 (de) 1996-02-15
DE69116126T2 true DE69116126T2 (de) 1996-07-04

Family

ID=12378238

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69116126T Expired - Fee Related DE69116126T2 (de) 1991-02-27 1991-09-05 Bildgebender Durchflusszytometer

Country Status (5)

Country Link
US (1) US5159398A (de)
EP (1) EP0501007B1 (de)
JP (1) JP3084295B2 (de)
CA (1) CA2050758A1 (de)
DE (1) DE69116126T2 (de)

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JP3084296B2 (ja) * 1991-02-27 2000-09-04 シスメックス株式会社 フローイメージサイトメータ
JP3121849B2 (ja) * 1991-02-27 2001-01-09 シスメックス株式会社 フローイメージサイトメータ
JP3212647B2 (ja) * 1991-10-24 2001-09-25 シスメックス株式会社 イメージングフローサイトメータ
JP3102935B2 (ja) * 1991-11-20 2000-10-23 シスメックス株式会社 イメージングフローサイトメータ
JP3102938B2 (ja) * 1991-12-30 2000-10-23 シスメックス株式会社 粒子画像分析装置
JP3187129B2 (ja) * 1992-04-01 2001-07-11 シスメックス株式会社 粒子分析装置
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US5719948A (en) * 1994-06-24 1998-02-17 Angstrom Technologies, Inc. Apparatus and methods for fluorescent imaging and optical character reading
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JP3127111B2 (ja) * 1996-02-22 2001-01-22 株式会社日立製作所 フロー式粒子画像解析方法および装置
US5894347A (en) * 1997-06-16 1999-04-13 Johnson & Johnson Clinical Diagnostics, Inc. Fluorimeter and detection method
US6115119A (en) * 1997-10-21 2000-09-05 Bigelow Laboratory For Ocean Science Device and method for studying particles in a fluid
US8131053B2 (en) 1999-01-25 2012-03-06 Amnis Corporation Detection of circulating tumor cells using imaging flow cytometry
US6975400B2 (en) * 1999-01-25 2005-12-13 Amnis Corporation Imaging and analyzing parameters of small moving objects such as cells
US7057732B2 (en) * 1999-01-25 2006-06-06 Amnis Corporation Imaging platform for nanoparticle detection applied to SPR biomolecular interaction analysis
US6671044B2 (en) 1999-01-25 2003-12-30 Amnis Corporation Imaging and analyzing parameters of small moving objects such as cells in broad flat flow
US8885913B2 (en) 1999-01-25 2014-11-11 Amnis Corporation Detection of circulating tumor cells using imaging flow cytometry
US8005314B2 (en) 2005-12-09 2011-08-23 Amnis Corporation Extended depth of field imaging for high speed object analysis
US6707551B2 (en) * 2000-01-24 2004-03-16 Amnis Corporation Multipass cavity for illumination and excitation of moving objects
US6249341B1 (en) 1999-01-25 2001-06-19 Amnis Corporation Imaging and analyzing parameters of small moving objects such as cells
US7450229B2 (en) 1999-01-25 2008-11-11 Amnis Corporation Methods for analyzing inter-cellular phenomena
US6608682B2 (en) 1999-01-25 2003-08-19 Amnis Corporation Imaging and analyzing parameters of small moving objects such as cells
US8406498B2 (en) 1999-01-25 2013-03-26 Amnis Corporation Blood and cell analysis using an imaging flow cytometer
US6473176B2 (en) 1999-01-25 2002-10-29 Amnis Corporation Imaging and analyzing parameters of small moving objects such as cells
US20060257884A1 (en) * 2004-05-20 2006-11-16 Amnis Corporation Methods for preparing and analyzing cells having chromosomal abnormalities
US6580504B1 (en) 1999-01-25 2003-06-17 Amnis Corporation Multipass cavity for illumination and excitation of moving objects
WO2002017219A1 (en) 2000-08-25 2002-02-28 Amnis Corporation Measuring the velocity of small moving objects such as cells
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US6934408B2 (en) * 2000-08-25 2005-08-23 Amnis Corporation Method and apparatus for reading reporter labeled beads
US6608680B2 (en) 2000-08-25 2003-08-19 Amnis Corporation TDI imaging system for kinetic studies
US6875973B2 (en) * 2000-08-25 2005-04-05 Amnis Corporation Auto focus for a flow imaging system
US6778263B2 (en) * 2000-08-25 2004-08-17 Amnis Corporation Methods of calibrating an imaging system using calibration beads
US20020028434A1 (en) * 2000-09-06 2002-03-07 Guava Technologies, Inc. Particle or cell analyzer and method
AU2001297843A1 (en) 2000-10-12 2002-12-23 Amnis Corporation Imaging and analyzing parameters of small moving objects such as cells
AU2002211913A1 (en) 2000-10-12 2002-04-22 Amnis Corporation Multipass cavity for illumination and excitation of moving objects
CA2445960A1 (en) * 2001-02-21 2002-12-19 Amnis Corporation Method and apparatus for labeling and analyzing cellular components
JP4763159B2 (ja) * 2001-06-15 2011-08-31 シスメックス株式会社 フローサイトメータ
WO2002086416A2 (en) * 2001-04-25 2002-10-31 Amnis Corporation Method and apparatus for correcting crosstalk and spatial resolution for multichannel imaging
WO2003009579A2 (en) 2001-07-17 2003-01-30 Amnis Corporation Computational methods for the segmentation of images of objects from background in a flow imaging instrument
KR101149880B1 (ko) * 2003-08-13 2012-05-24 루미넥스 코포레이션 유세포 분석기식 측정 시스템의 하나 이상의 파라미터의 제어 방법
US8150136B2 (en) 2004-03-16 2012-04-03 Amnis Corporation Image based quantitation of molecular translocation
US8103080B2 (en) 2004-03-16 2012-01-24 Amnis Corporation Method for imaging and differential analysis of cells
US8953866B2 (en) 2004-03-16 2015-02-10 Amnis Corporation Method for imaging and differential analysis of cells
US8498695B2 (en) * 2006-12-22 2013-07-30 Novadaq Technologies Inc. Imaging system with a single color image sensor for simultaneous fluorescence and color video endoscopy
US7867778B2 (en) * 2007-02-23 2011-01-11 Visiongate, Inc. Fluid focusing for positional control of a specimen for 3-D imaging
US8454895B2 (en) * 2007-05-03 2013-06-04 Nanyang Technological University Online contaminant detection and removal system
WO2009073649A1 (en) 2007-12-04 2009-06-11 Particle Measuring Systems, Inc. Non-orthogonal particle detection systems and methods
US8143600B2 (en) 2008-02-18 2012-03-27 Visiongate, Inc. 3D imaging of live cells with ultraviolet radiation
JP5231625B2 (ja) 2008-03-18 2013-07-10 ノヴァダク テクノロジーズ インコーポレイテッド Ｎｉｒ画像およびフルカラー画像を獲得するための画像化システムおよびその作動方法
US8090183B2 (en) * 2009-03-12 2012-01-03 Visiongate, Inc. Pattern noise correction for pseudo projections
US7796256B2 (en) * 2008-05-05 2010-09-14 Fluid Imaging Technologies, Inc. Oil-immersion enhanced imaging flow cytometer
US20090283697A1 (en) * 2008-05-16 2009-11-19 Fluid Imaging Technologies, Inc. System and method for monitoring blue-green algae in a fluid
US9151943B2 (en) 2008-08-04 2015-10-06 Fluid Imaging Technologies, Inc. System and method for monitoring birefringent particles in a fluid
US8345239B1 (en) 2008-08-04 2013-01-01 Fluid Imaging Technologies, Inc. System and method for monitoring birefringent particles in a fluid
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US8254023B2 (en) 2009-02-23 2012-08-28 Visiongate, Inc. Optical tomography system with high-speed scanner
US8155420B2 (en) * 2009-05-21 2012-04-10 Visiongate, Inc System and method for detecting poor quality in 3D reconstructions
US8451524B2 (en) 2009-09-29 2013-05-28 Amnis Corporation Modifying the output of a laser to achieve a flat top in the laser's Gaussian beam intensity profile
US8817115B1 (en) 2010-05-05 2014-08-26 Amnis Corporation Spatial alignment of image data from a multichannel detector using a reference image
US8408464B2 (en) 2011-02-03 2013-04-02 Metrologic Instruments, Inc. Auto-exposure method using continuous video frames under controlled illumination
US8994945B2 (en) 2011-10-27 2015-03-31 Fluid Imaging Technologies, Inc. Method of treatment analysis with particle imaging
US8879797B2 (en) 2012-05-25 2014-11-04 Fluid Imaging Technologies, Inc. System and method for total internal reflection enhanced imaging flow cytometry
US9983115B2 (en) 2015-09-21 2018-05-29 Fluid Imaging Technologies, Inc. System and method for monitoring particles in a fluid using ratiometric cytometry
CN113648067A (zh) 2015-11-13 2021-11-16 史赛克欧洲运营有限公司 用于目标的照明和成像的系统和方法
US11069054B2 (en) 2015-12-30 2021-07-20 Visiongate, Inc. System and method for automated detection and monitoring of dysplasia and administration of immunotherapy and chemotherapy
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CN106525807A (zh) * 2017-01-20 2017-03-22 武汉能斯特科技有限公司 一种测量流体延迟发光的方法和装置
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Also Published As

Publication number Publication date
DE69116126D1 (de) 1996-02-15
JPH04270962A (ja) 1992-09-28
JP3084295B2 (ja) 2000-09-04
CA2050758A1 (en) 1992-08-28
EP0501007B1 (de) 1996-01-03
US5159398A (en) 1992-10-27
EP0501007A3 (en) 1992-12-02
EP0501007A2 (de) 1992-09-02

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee