DE69116750D1 - 9-Purinyl-Phosphonsäurederivate - Google Patents
9-Purinyl-PhosphonsäurederivateInfo
- Publication number
- DE69116750D1 DE69116750D1 DE69116750T DE69116750T DE69116750D1 DE 69116750 D1 DE69116750 D1 DE 69116750D1 DE 69116750 T DE69116750 T DE 69116750T DE 69116750 T DE69116750 T DE 69116750T DE 69116750 D1 DE69116750 D1 DE 69116750D1
- Authority
- DE
- Germany
- Prior art keywords
- purinyl
- acid derivatives
- phosphonic acid
- antilymphoma
- antileukemic
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/675—Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/06—Antigout agents, e.g. antihyperuricemic or uricosuric agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
- C07F9/65616—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings containing the ring system having three or more than three double bonds between ring members or between ring members and non-ring members, e.g. purine or analogs
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP90401940 | 1990-07-04 |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69116750D1 true DE69116750D1 (de) | 1996-03-14 |
DE69116750T2 DE69116750T2 (de) | 1996-11-14 |
Family
ID=8205733
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69116750T Expired - Lifetime DE69116750T2 (de) | 1990-07-04 | 1991-06-24 | 9-Purinyl-Phosphonsäurederivate |
Country Status (22)
Country | Link |
---|---|
US (2) | US5538978A (de) |
EP (1) | EP0465297B1 (de) |
JP (1) | JP3006919B2 (de) |
KR (1) | KR100217807B1 (de) |
CN (1) | CN1031713C (de) |
AT (1) | ATE133678T1 (de) |
AU (1) | AU643533B2 (de) |
CA (1) | CA2045783C (de) |
DE (1) | DE69116750T2 (de) |
DK (1) | DK0465297T3 (de) |
ES (1) | ES2085446T3 (de) |
FI (1) | FI101793B1 (de) |
GR (1) | GR3019793T3 (de) |
HU (1) | HU208832B (de) |
IE (1) | IE72096B1 (de) |
IL (1) | IL98702A (de) |
MX (1) | MX9203682A (de) |
NO (1) | NO180541C (de) |
NZ (1) | NZ238774A (de) |
PT (1) | PT98198B (de) |
TW (1) | TW199896B (de) |
ZA (1) | ZA914978B (de) |
Families Citing this family (36)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES2085446T3 (es) * | 1990-07-04 | 1996-06-01 | Merrell Pharma Inc | Derivados de acido 9-purinil fosfonico. |
EP0531597A1 (de) * | 1991-09-12 | 1993-03-17 | Merrell Dow Pharmaceuticals Inc. | Ungesättigte azyklische Phosphonsäure Purinderivats und Pyrimidinderivate |
US5817672A (en) * | 1991-12-06 | 1998-10-06 | Hoechst Marion Roussel, Inc. | Trans cyclopentanyl purine analogs useful as immunosuppressants |
US5723466A (en) * | 1991-12-06 | 1998-03-03 | Hoechst Marion Roussel, Inc. | Trans cyclopentanyl purine analogs useful as immunosuppressants |
CA2084222C (en) * | 1991-12-06 | 2004-04-06 | David R. Borcherding | Novel trans cyclopentanyl purine analogs useful as immunosuppressants |
US5817660A (en) * | 1991-12-06 | 1998-10-06 | Hoechst Marion Roussel, Inc. | Trans cyclopentanyl purine analogs useful as immunosuppressants |
US5817661A (en) * | 1991-12-06 | 1998-10-06 | Hoechst Marion Roussel, Inc. | Trans cyclopentanyl purine analogs useful as immunosuppressants |
KR100386685B1 (ko) * | 1993-09-17 | 2003-12-31 | 길리애드 사이언시즈, 인코포레이티드 | 뉴클레오타이드동족체류 |
US5798340A (en) * | 1993-09-17 | 1998-08-25 | Gilead Sciences, Inc. | Nucleotide analogs |
US5656745A (en) * | 1993-09-17 | 1997-08-12 | Gilead Sciences, Inc. | Nucleotide analogs |
US5703058A (en) * | 1995-01-27 | 1997-12-30 | Emory University | Compositions containing 5-fluoro-2',3'-didehydro-2',3'-dideoxycytidine or a mono-, di-, or triphosphate thereof and a second antiviral agent |
MY141789A (en) * | 2001-01-19 | 2010-06-30 | Lg Chem Investment Ltd | Novel acyclic nucleoside phosphonate derivatives, salts thereof and process for the preparation of the same. |
WO2003037860A2 (en) | 2001-10-30 | 2003-05-08 | Conforma Therapeutics Corporation | Purine analogs having hsp90-inhibiting activity |
DE60315023T2 (de) | 2002-04-26 | 2008-04-03 | Gilead Sciences, Inc., Foster City | Anreicherung in der zelle an phosphonat analoga von hiv protease inhibitor verbindungen und die verbindungen selbst |
CA2522845A1 (en) | 2003-04-25 | 2004-11-11 | Gilead Sciences, Inc. | Kinase inhibitor phosphonate conjugates |
US7452901B2 (en) | 2003-04-25 | 2008-11-18 | Gilead Sciences, Inc. | Anti-cancer phosphonate analogs |
JP5069463B2 (ja) | 2003-04-25 | 2012-11-07 | ギリアード サイエンシーズ, インコーポレイテッド | 抗ウイルス性ホスホネート類似物 |
US7407965B2 (en) | 2003-04-25 | 2008-08-05 | Gilead Sciences, Inc. | Phosphonate analogs for treating metabolic diseases |
WO2004096285A2 (en) | 2003-04-25 | 2004-11-11 | Gilead Sciences, Inc. | Anti-infective phosphonate conjugates |
US7470724B2 (en) | 2003-04-25 | 2008-12-30 | Gilead Sciences, Inc. | Phosphonate compounds having immuno-modulatory activity |
US7432261B2 (en) | 2003-04-25 | 2008-10-07 | Gilead Sciences, Inc. | Anti-inflammatory phosphonate compounds |
WO2005002626A2 (en) | 2003-04-25 | 2005-01-13 | Gilead Sciences, Inc. | Therapeutic phosphonate compounds |
US7427636B2 (en) | 2003-04-25 | 2008-09-23 | Gilead Sciences, Inc. | Inosine monophosphate dehydrogenase inhibitory phosphonate compounds |
US7129244B2 (en) | 2003-09-18 | 2006-10-31 | Conforma Therapeutics Corporation | Triazolopyrimidines and related analogs as HSP90-inhibitors |
WO2005044279A1 (en) * | 2003-10-24 | 2005-05-19 | Gilead Sciences, Inc. | Purine nucleoside phosphonate conjugates |
WO2005044308A1 (en) | 2003-10-24 | 2005-05-19 | Gilead Sciences, Inc. | Phosphonate analogs of antimetabolites |
WO2005042773A1 (en) | 2003-10-24 | 2005-05-12 | Gilead Sciences, Inc. | Methods and compositions for identifying therapeutic compounds |
CA2548753A1 (en) | 2003-12-22 | 2005-07-14 | Gilead Sciences, Inc. | 4-substituted carbovir and abacavir-derivatives as well as related compounds with hiv and hcv antiviral activity |
ME01945B (me) | 2004-07-27 | 2011-12-31 | Gilead Sciences Inc | Nukleozid-fosfonatni konjugati kao sredstva protiv hiv-a |
US7544672B2 (en) | 2005-03-30 | 2009-06-09 | Conforma Therapeutics Corporation | Alkynyl pyrrolo[2,3-d]pyrimidines and related analogs as HSP90-inhibitors |
US8158108B2 (en) * | 2006-06-28 | 2012-04-17 | S.C. Johnson & Son, Inc. | VOC-free compressed gas aerosol compositions |
US8178078B2 (en) * | 2008-06-13 | 2012-05-15 | S.C. Johnson & Son, Inc. | Compositions containing a solvated active agent suitable for dispensing as a compressed gas aerosol |
US8658617B2 (en) | 2008-07-08 | 2014-02-25 | Gilead Sciences, Inc. | Salts of HIV inhibitor compounds |
KR101692133B1 (ko) | 2015-01-13 | 2017-01-02 | 연세대학교 원주산학협력단 | 폴리이미드 수용액을 이용한 폴리이미드 성형방법 |
CN105061504A (zh) * | 2015-09-16 | 2015-11-18 | 湖南大学 | P-炔基磷酸酯类化合物的制备方法 |
EP3960740B1 (de) | 2017-08-01 | 2023-11-15 | Gilead Sciences, Inc. | Kristalline formen von ethyl((s)-((((2r,5r)-5-(6-amino-9h-purin-9-yl)-4-fluor-2,5-dihydrofuran-2-yl)oxy)methyl)(phenoxy)phosphoryl)-l-alaninat (gs-9131) vanillate zur behandlung von virusinfektionen |
Family Cites Families (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA1288098C (en) * | 1984-08-24 | 1991-08-27 | Richard L. Tolman | 4-(guanin-9-yl)butanals and their 3-oxa, 3-thia and 2-ene derivatives having antiviral and antitumor activity |
US4988702A (en) * | 1986-08-26 | 1991-01-29 | Warner-Lambert Company | Novel 9-deazaguanines |
EP0328834A1 (de) * | 1988-02-16 | 1989-08-23 | Merrell Dow Pharmaceuticals Inc. | Aspartat Transcarbamylase Inhibitoren |
EP0335770B1 (de) * | 1988-04-01 | 1997-01-15 | Merrell Pharmaceuticals Inc. | Derivate von Fluorphosphonat-Nukleotiden |
US4927830A (en) * | 1988-04-08 | 1990-05-22 | The Regents Of The University Of Michigan | Acyclic pyrrolo[2,3-D]pyrimidine analogs as antiviral agents |
EP0338168A1 (de) * | 1988-04-19 | 1989-10-25 | Merrell Dow Pharmaceuticals Inc. | Phosphonoalkylpurin-Derivate |
ATE98249T1 (de) * | 1988-04-19 | 1993-12-15 | Merrell Dow Pharma | Phosphonoalkylpurin-derivate. |
JPH02124898A (ja) * | 1988-04-28 | 1990-05-14 | Nippon Kayaku Co Ltd | プリン塩基を有する新規化合物、その用途及び中間体 |
JPH02124897A (ja) * | 1988-07-28 | 1990-05-14 | Nippon Kayaku Co Ltd | エリスロフラノシルヌクレオシド誘導体の製造法及び新規誘導体 |
GB8827339D0 (en) * | 1988-11-23 | 1988-12-29 | Wellcome Found | Antiviral compounds |
DE58902899D1 (de) * | 1988-12-14 | 1993-01-14 | Ciba Geigy Ag | 2',3'-dideoxypurinnucleosid/purinnucleosid-phosphorylase-inhibitor kombinationstherapie und zusammensetzungen dafuer. |
ES2085446T3 (es) * | 1990-07-04 | 1996-06-01 | Merrell Pharma Inc | Derivados de acido 9-purinil fosfonico. |
EP0468119A1 (de) * | 1990-07-24 | 1992-01-29 | Merrell Dow Pharmaceuticals Inc. | Neue Carbocyclische Analoge einiger Nukleoside |
EP0477454A1 (de) * | 1990-09-28 | 1992-04-01 | Merrell Dow Pharmaceuticals Inc. | Phosphonatderivate von bestimmten Nucleosiden |
-
1991
- 1991-06-24 ES ES91401700T patent/ES2085446T3/es not_active Expired - Lifetime
- 1991-06-24 AT AT91401700T patent/ATE133678T1/de not_active IP Right Cessation
- 1991-06-24 DE DE69116750T patent/DE69116750T2/de not_active Expired - Lifetime
- 1991-06-24 EP EP91401700A patent/EP0465297B1/de not_active Expired - Lifetime
- 1991-06-24 DK DK91401700.9T patent/DK0465297T3/da active
- 1991-06-27 CA CA002045783A patent/CA2045783C/en not_active Expired - Lifetime
- 1991-06-27 ZA ZA914978A patent/ZA914978B/xx unknown
- 1991-06-27 AU AU79414/91A patent/AU643533B2/en not_active Ceased
- 1991-06-28 TW TW080105043A patent/TW199896B/zh active
- 1991-06-28 NZ NZ238774A patent/NZ238774A/en unknown
- 1991-07-01 IL IL9870291A patent/IL98702A/xx not_active IP Right Cessation
- 1991-07-03 HU HU912253A patent/HU208832B/hu not_active IP Right Cessation
- 1991-07-03 CN CN91104477A patent/CN1031713C/zh not_active Expired - Fee Related
- 1991-07-03 PT PT98198A patent/PT98198B/pt not_active IP Right Cessation
- 1991-07-03 IE IE232991A patent/IE72096B1/en not_active IP Right Cessation
- 1991-07-03 FI FI913236A patent/FI101793B1/fi active
- 1991-07-03 NO NO912606A patent/NO180541C/no unknown
- 1991-07-04 KR KR1019910011290A patent/KR100217807B1/ko not_active IP Right Cessation
- 1991-07-04 JP JP3189498A patent/JP3006919B2/ja not_active Expired - Lifetime
-
1992
- 1992-06-29 MX MX9203682A patent/MX9203682A/es unknown
-
1994
- 1994-11-08 US US08/336,703 patent/US5538978A/en not_active Expired - Lifetime
-
1995
- 1995-06-06 US US08/469,097 patent/US5527803A/en not_active Expired - Fee Related
-
1996
- 1996-04-29 GR GR960401173T patent/GR3019793T3/el unknown
Also Published As
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DE69116750D1 (de) | 9-Purinyl-Phosphonsäurederivate | |
DE69333109D1 (de) | Therapeutische nukleoside | |
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DK0494370T3 (da) | Antivirale (phosphonomethoxy)methoxypurin/pyrimidinderivater | |
ATE124936T1 (de) | 5-benzyl barbitursäurederivate. | |
IL98110A0 (en) | N-(3-fluoro-2-phosphonylmethoxypropyl)derivatives of purine and pyrimidine heterocyclic bases,their preparation and use | |
GR3036577T3 (en) | Novel carbocyclic adenosine analogs useful as immunosuppressants. | |
ATE147746T1 (de) | Derivate von fluorphosphonat-nukleotiden | |
DK1068209T3 (da) | Fremgangsmåde til fremstilling af purinderivater og deres mellemprodukter | |
EP0335770A3 (de) | Derivate von Fluorphosphonat-Nukleotiden | |
SE8504657L (sv) | Nya 5-fluor-2'-deoxiuridinderivat och salter derav, forfarande for deras framstellning och antitumormedel innehallande dessa | |
NO974512D0 (no) | Fremgangsmåte for syntese av nukleosid-analoger | |
TH9308A (th) | พิริมิดีนคลีโอไซด์ที่ใช้ต้านไวรัส | |
TH9308EX (th) | พิริมิดีนคลีโอไซด์ที่ใช้ต้านไวรัส |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition | ||
8327 | Change in the person/name/address of the patent owner |
Owner name: AVENTIS INC. (N.D.GES.D. STAATES PENNSYLVANIA), GR |
|
8327 | Change in the person/name/address of the patent owner |
Owner name: AVENTISUB II INC., GREENVILLE, DEL., US |