DE69122494T2 - Vorrichtung zur transdermalen Applikation von Protein- oder Peptid-Medikamenten - Google Patents

Vorrichtung zur transdermalen Applikation von Protein- oder Peptid-Medikamenten

Info

Publication number
DE69122494T2
DE69122494T2 DE69122494T DE69122494T DE69122494T2 DE 69122494 T2 DE69122494 T2 DE 69122494T2 DE 69122494 T DE69122494 T DE 69122494T DE 69122494 T DE69122494 T DE 69122494T DE 69122494 T2 DE69122494 T2 DE 69122494T2
Authority
DE
Germany
Prior art keywords
protein
transdermal application
peptide drugs
peptide
drugs
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69122494T
Other languages
English (en)
Other versions
DE69122494D1 (de
Inventor
Hai Bang Lee
Bung Chul Shin
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Korea Research Institute of Chemical Technology KRICT
Original Assignee
Korea Research Institute of Chemical Technology KRICT
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from KR1019890015519A external-priority patent/KR920002264B1/ko
Priority claimed from KR1019900007357A external-priority patent/KR930000062B1/ko
Application filed by Korea Research Institute of Chemical Technology KRICT filed Critical Korea Research Institute of Chemical Technology KRICT
Publication of DE69122494D1 publication Critical patent/DE69122494D1/de
Application granted granted Critical
Publication of DE69122494T2 publication Critical patent/DE69122494T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/70Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A61K9/703Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0002Galenical forms characterised by the drug release technique; Application systems commanded by energy
    • A61K9/0009Galenical forms characterised by the drug release technique; Application systems commanded by energy involving or responsive to electricity, magnetism or acoustic waves; Galenical aspects of sonophoresis, iontophoresis, electroporation or electroosmosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0019Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0021Intradermal administration, e.g. through microneedle arrays, needleless injectors
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/70Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A61K9/703Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
    • A61K9/7084Transdermal patches having a drug layer or reservoir, and one or more separate drug-free skin-adhesive layers, e.g. between drug reservoir and skin, or surrounding the drug reservoir; Liquid-filled reservoir patches
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00Electrotherapy; Circuits therefor
    • A61N1/02Details
    • A61N1/04Electrodes
    • A61N1/0404Electrodes for external use
    • A61N1/0408Use-related aspects
    • A61N1/0428Specially adapted for iontophoresis, e.g. AC, DC or including drug reservoirs
    • A61N1/0432Anode and cathode
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00Electrotherapy; Circuits therefor
    • A61N1/02Details
    • A61N1/04Electrodes
    • A61N1/0404Electrodes for external use
    • A61N1/0408Use-related aspects
    • A61N1/0428Specially adapted for iontophoresis, e.g. AC, DC or including drug reservoirs
    • A61N1/0448Drug reservoir
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00Electrotherapy; Circuits therefor
    • A61N1/18Applying electric currents by contact electrodes
    • A61N1/20Applying electric currents by contact electrodes continuous direct currents
    • A61N1/30Apparatus for iontophoresis, i.e. transfer of media in ionic state by an electromotoric force into the body, or cataphoresis
    • A61N1/303Constructional details
    • A61N1/306Arrangements where at least part of the apparatus is introduced into the body
DE69122494T 1989-10-27 1991-04-19 Vorrichtung zur transdermalen Applikation von Protein- oder Peptid-Medikamenten Expired - Fee Related DE69122494T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
KR1019890015519A KR920002264B1 (ko) 1989-10-27 1989-10-27 인슐린의 경피투여방법과 그에 사용되는 투여기구
KR1019900007357A KR930000062B1 (ko) 1990-05-22 1990-05-22 단백 및 펩타이드성 약물의 경피투여조성물
EP91106304A EP0509122B1 (de) 1989-10-27 1991-04-19 Vorrichtung zur transdermalen Applikation von Protein- oder Peptid-Medikamenten

Publications (2)

Publication Number Publication Date
DE69122494D1 DE69122494D1 (de) 1996-11-07
DE69122494T2 true DE69122494T2 (de) 1997-02-06

Family

ID=26628108

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69122494T Expired - Fee Related DE69122494T2 (de) 1989-10-27 1991-04-19 Vorrichtung zur transdermalen Applikation von Protein- oder Peptid-Medikamenten

Country Status (6)

Country Link
US (1) US5250023A (de)
EP (3) EP0429842B1 (de)
JP (1) JPH0614980B2 (de)
DE (1) DE69122494T2 (de)
DK (1) DK0509122T3 (de)
ES (1) ES2093652T3 (de)

Families Citing this family (305)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0429842B1 (de) * 1989-10-27 1996-08-28 Korea Research Institute Of Chemical Technology Vorrichtung zur transdermalen Applikation von Protein- oder Peptid-Medikamenten
US5279544A (en) * 1990-12-13 1994-01-18 Sil Medics Ltd. Transdermal or interdermal drug delivery devices
CA2087087C (en) * 1992-01-22 2000-07-18 Burton H. Sage, Jr. Molecules for iontophoretic delivery
US20050159699A1 (en) * 1993-09-30 2005-07-21 Vyteris, Inc. Iontophoretic drug delivery device and reservoir and method of making same
US5505715A (en) * 1994-02-25 1996-04-09 Bristol-Myers Squibb Company Iontophoretic transdermal delivery of deoxyspergualin compounds
JP3425469B2 (ja) * 1994-03-25 2003-07-14 東光薬品工業株式会社 ジェットインジェクション経皮吸収装置
CA2205444A1 (en) * 1994-12-09 1996-06-13 Novartis Ag Transdermal system
US5629184A (en) * 1995-01-25 1997-05-13 Amgen Inc. Cationic copolymers of vinylamine and vinyl alcohol for the delivery of oligonucleotides
US5853383A (en) * 1995-05-03 1998-12-29 Alza Corporation Preparation for formulations for electrotransport drug delivery
US5747453A (en) 1995-06-06 1998-05-05 Alza Corporation Method for increasing the electrotransport flux of polypeptides
IT1285405B1 (it) * 1995-06-06 1998-06-03 Alza Corp Modificazione di farmaci polipeptidici per accrescere il flusso per elettrotrasporto.
US5736154A (en) * 1996-03-11 1998-04-07 Fuisz Technologies Ltd. Transdermal delivery system
JP3459724B2 (ja) * 1996-03-17 2003-10-27 久光製薬株式会社 イオントフォレーシス用電極デバイス
US6333189B1 (en) 1996-06-06 2001-12-25 Alza Corporation Method of making an electrotransport device
DE69719761T2 (de) * 1996-06-18 2003-12-18 Alza Corp Vorrichtung zur verbesserung der transdermalen verabreichung von medikamenten oder der abnahme von körperflüssigkeiten
AUPO066096A0 (en) * 1996-06-26 1996-07-18 Peptide Delivery Systems Pty Ltd Oral delivery of peptides
CA2259437C (en) * 1996-07-03 2006-12-05 Altea Technologies, Inc. Multiple mechanical microporation of skin or mucosa
US5857993A (en) * 1996-07-12 1999-01-12 Empi, Inc. Process of making an iontophoresis electrode
US5941843A (en) * 1996-07-12 1999-08-24 Empi, Inc. Iontophoresis electrode
US5871461A (en) * 1996-07-12 1999-02-16 Empi, Inc. Method of making an iontophoresis electrode
WO1998011937A1 (en) * 1996-09-17 1998-03-26 Deka Products Limited Partnership System for delivery of drugs by transport
US6797276B1 (en) 1996-11-14 2004-09-28 The United States Of America As Represented By The Secretary Of The Army Use of penetration enhancers and barrier disruption agents to enhance the transcutaneous immune response
US20060002949A1 (en) 1996-11-14 2006-01-05 Army Govt. Of The Usa, As Rep. By Secretary Of The Office Of The Command Judge Advocate, Hq Usamrmc. Transcutaneous immunization without heterologous adjuvant
US5980898A (en) 1996-11-14 1999-11-09 The United States Of America As Represented By The U.S. Army Medical Research & Material Command Adjuvant for transcutaneous immunization
EP0957972B1 (de) * 1996-12-20 2003-03-19 Alza Corporation Vorrichtung und verfahren zur erhöhung des transdermalen wirkstoffeflusses
US6527716B1 (en) 1997-12-30 2003-03-04 Altea Technologies, Inc. Microporation of tissue for delivery of bioactive agents
US5882677A (en) * 1997-09-30 1999-03-16 Becton Dickinson And Company Iontophoretic patch with hydrogel reservoir
US6775569B2 (en) * 1997-11-05 2004-08-10 Hisamitsu Pharmaceutical Co., Inc. Electroporation device for in vivo delivery of therapeutic agents
CA2309955A1 (en) * 1997-11-12 1999-05-20 Alza Corporation Method for decreasing self-association of polypeptides
US6918901B1 (en) 1997-12-10 2005-07-19 Felix Theeuwes Device and method for enhancing transdermal agent flux
EP1911488A3 (de) * 1997-12-11 2008-12-03 Alza Corporation Vorrichtung zur Verstärkung des Flusses transdermaler Mittel
CN1206004C (zh) 1997-12-11 2005-06-15 阿尔扎有限公司 增强透皮物剂流量的装置
ATE221400T1 (de) 1997-12-11 2002-08-15 Alza Corp Vorrichtung zur erhöhung des transdermalen wirkstoffeflusses
PT1037686E (pt) * 1997-12-11 2005-10-31 Alza Corp Aparelho para potenciar o fluxo de agente transdermico
JP4154017B2 (ja) * 1997-12-30 2008-09-24 久光製薬株式会社 イオントフォレーシス装置および薬物ユニット
US6173202B1 (en) 1998-03-06 2001-01-09 Spectrx, Inc. Method and apparatus for enhancing flux rates of a fluid in a microporated biological tissue
US6503231B1 (en) 1998-06-10 2003-01-07 Georgia Tech Research Corporation Microneedle device for transport of molecules across tissue
US7344499B1 (en) 1998-06-10 2008-03-18 Georgia Tech Research Corporation Microneedle device for extraction and sensing of bodily fluids
WO1999064580A1 (en) * 1998-06-10 1999-12-16 Georgia Tech Research Corporation Microneedle devices and methods of manufacture and use thereof
AU761522B2 (en) * 1998-07-13 2003-06-05 Genetronics, Inc. Method and apparatus for electrically assisted topical delivery of agents for cosmetic applications
CN1315877A (zh) 1998-08-31 2001-10-03 强生消费者公司 含刀片的电传送装置
US20050171021A1 (en) * 1998-11-12 2005-08-04 Cormier Michel J. Buffered drug formulations for transdermal
US6475514B1 (en) 1998-12-03 2002-11-05 Andrew Blitzer Athletic patch
US7273618B2 (en) * 1998-12-09 2007-09-25 Chiron Corporation Method for administering agents to the central nervous system
WO2000062857A1 (en) 1999-04-16 2000-10-26 Johnson & Johnson Consumer Companies, Inc. Electrotransport delivery system comprising internal sensors
CA2366900A1 (en) * 1999-04-16 2000-10-26 Stephen J. Wisniewski Drug delivery device comprising a dual chamber reservoir
ATE256421T1 (de) * 1999-05-25 2004-01-15 Medicotest As Hautelektrode
EP1187653B1 (de) 1999-06-04 2010-03-31 Georgia Tech Research Corporation Vorrichtungen zur vergrösserten penetration von mikronadeln in biologischen hautschichten
US6611707B1 (en) 1999-06-04 2003-08-26 Georgia Tech Research Corporation Microneedle drug delivery device
US6743211B1 (en) 1999-11-23 2004-06-01 Georgia Tech Research Corporation Devices and methods for enhanced microneedle penetration of biological barriers
US20040039342A1 (en) 2000-06-08 2004-02-26 Jonathan Eppstein Transdermal integrated actuator device, methods of making and using same
US6256533B1 (en) * 1999-06-09 2001-07-03 The Procter & Gamble Company Apparatus and method for using an intracutaneous microneedle array
US6379324B1 (en) * 1999-06-09 2002-04-30 The Procter & Gamble Company Intracutaneous microneedle array apparatus
US6312612B1 (en) 1999-06-09 2001-11-06 The Procter & Gamble Company Apparatus and method for manufacturing an intracutaneous microneedle array
AU6076200A (en) 1999-07-08 2001-01-30 Johnson & Johnson Consumer Companies, Inc. Exothermic bandage
US6890553B1 (en) 1999-07-08 2005-05-10 Johnson & Johnson Consumer Companies, Inc. Exothermic topical delivery device
US20030078499A1 (en) * 1999-08-12 2003-04-24 Eppstein Jonathan A. Microporation of tissue for delivery of bioactive agents
US7133717B2 (en) 1999-08-25 2006-11-07 Johnson & Johnson Consumer Companies, Inc. Tissue electroperforation for enhanced drug delivery and diagnostic sampling
US7113821B1 (en) 1999-08-25 2006-09-26 Johnson & Johnson Consumer Companies, Inc. Tissue electroperforation for enhanced drug delivery
JP4414517B2 (ja) 1999-09-01 2010-02-10 久光製薬株式会社 イオントフォレーシス用デバイス構造体
US6251083B1 (en) 1999-09-07 2001-06-26 Amira Medical Interstitial fluid methods and devices for determination of an analyte in the body
US6623457B1 (en) * 1999-09-22 2003-09-23 Becton, Dickinson And Company Method and apparatus for the transdermal administration of a substance
US6190367B1 (en) 1999-09-22 2001-02-20 Becton, Dickinson And Company Medical site prep device
US6835184B1 (en) 1999-09-24 2004-12-28 Becton, Dickinson And Company Method and device for abrading skin
US6331266B1 (en) 1999-09-29 2001-12-18 Becton Dickinson And Company Process of making a molded device
US20020095134A1 (en) * 1999-10-14 2002-07-18 Pettis Ronald J. Method for altering drug pharmacokinetics based on medical delivery platform
US8465468B1 (en) 2000-06-29 2013-06-18 Becton, Dickinson And Company Intradermal delivery of substances
US20020156453A1 (en) * 1999-10-14 2002-10-24 Pettis Ronald J. Method and device for reducing therapeutic dosage
AU3081601A (en) * 1999-11-15 2001-05-30 Velcro Industries B.V. Skin attachment member
DE60024312T2 (de) 1999-12-10 2006-08-17 Alza Corp., Mountain View Transdermale Wirkstoffabgabe von makromolekularen Wirkstoffen und Vorrichtung hierfür
JP4312407B2 (ja) 1999-12-10 2009-08-12 アルザ・コーポレーション 持続した経皮による薬物送達のための皮膚処理装置
US20030104041A1 (en) * 1999-12-16 2003-06-05 Tsung-Min Hsu Transdermal and topical administration of drugs using basic permeation enhancers
US6558695B2 (en) * 1999-12-16 2003-05-06 Dermatrends, Inc. Topical and transdermal administration of peptidyl drugs using hydroxide releasing agents as permeation enhancers
CA2394171A1 (en) 1999-12-16 2001-06-21 Alza Corporation Device for enhancing transdermal flux of sampled agents
US6565879B1 (en) 1999-12-16 2003-05-20 Dermatrends, Inc. Topical and transdermal administration of peptidyl drugs with hydroxide-releasing agents as skin permeation enhancers
US7013179B2 (en) * 2000-01-07 2006-03-14 Biowave Corporation Percutaneous electrode array
US20080033492A1 (en) * 2000-01-07 2008-02-07 Biowave Corporation Electro-therapy method
WO2001058506A2 (en) * 2000-02-10 2001-08-16 Power Paper Ltd. Drug delivery device and method
EP1276426A4 (de) * 2000-03-09 2008-03-19 Nanopass Ltd Systeme und verfahren zum transportieren von flüssigkeiten durch biologische barrieren und produktionstechniken für solche systeme
US7404815B2 (en) * 2000-05-01 2008-07-29 Lifescan, Inc. Tissue ablation by shear force for sampling biological fluids and delivering active agents
US6629949B1 (en) * 2000-05-08 2003-10-07 Sterling Medivations, Inc. Micro infusion drug delivery device
US6595947B1 (en) * 2000-05-22 2003-07-22 Becton, Dickinson And Company Topical delivery of vaccines
US6565532B1 (en) 2000-07-12 2003-05-20 The Procter & Gamble Company Microneedle apparatus used for marking skin and for dispensing semi-permanent subcutaneous makeup
ATE279879T1 (de) * 2000-05-29 2004-11-15 Medicotest As Elektrode zur herstellung eines elektrischen kontakts mit der haut
US6537242B1 (en) 2000-06-06 2003-03-25 Becton, Dickinson And Company Method and apparatus for enhancing penetration of a member for the intradermal sampling or administration of a substance
US6607513B1 (en) 2000-06-08 2003-08-19 Becton, Dickinson And Company Device for withdrawing or administering a substance and method of manufacturing a device
US9717451B2 (en) 2000-06-08 2017-08-01 Becton, Dickinson And Company Device for withdrawing or administering a substance and method of manufacturing a device
US20040175360A1 (en) * 2000-06-29 2004-09-09 Pettis Ronald J. Method for altering drug pharmacokinetics based on medical delivery platform
US20050008683A1 (en) * 2000-06-29 2005-01-13 Becton Dickinson And Company Method for delivering interferons to the intradermal compartment
US6589202B1 (en) 2000-06-29 2003-07-08 Becton Dickinson And Company Method and apparatus for transdermally sampling or administering a substance to a patient
US6440096B1 (en) 2000-07-14 2002-08-27 Becton, Dickinson And Co. Microdevice and method of manufacturing a microdevice
US6656147B1 (en) 2000-07-17 2003-12-02 Becton, Dickinson And Company Method and delivery device for the transdermal administration of a substance
DK1301123T3 (da) * 2000-07-19 2005-01-24 Medicotest As Hudelektrode med et bypass-element
DE60113848D1 (de) * 2000-07-25 2005-11-10 Medicotest As Olstykke Elektromedizinische elektrode mit einem schnappverbindungselement
CA2420343A1 (en) 2000-08-24 2002-02-28 Alza Corporation Method for transdermal nucleic acid sampling
US6749575B2 (en) * 2001-08-20 2004-06-15 Alza Corporation Method for transdermal nucleic acid sampling
US6690959B2 (en) 2000-09-01 2004-02-10 Medtronic, Inc. Skin-mounted electrodes with nano spikes
KR100764699B1 (ko) * 2000-09-08 2007-10-08 알자 코포레이션 경로 폐쇄 저해에 의한 경피 약물 플럭스 감소 저해방법
WO2002030506A2 (en) 2000-10-12 2002-04-18 Ink Jet Technology Ltd. Transdermal method
CA2425537C (en) * 2000-10-13 2009-09-08 Alza Corporation Microblade array impact applicator
EP1341453B1 (de) * 2000-10-13 2009-04-15 Alza Corporation Vorrichtung und verfahren zum durchstechen der haut mit micronadeln
US7419481B2 (en) * 2000-10-13 2008-09-02 Alza Corporation Apparatus and method for piercing skin with microprotrusions
NZ525295A (en) * 2000-10-13 2005-05-27 Alza Corp Microprotrusion member retainer for impact applicator
US7828827B2 (en) * 2002-05-24 2010-11-09 Corium International, Inc. Method of exfoliation of skin using closely-packed microstructures
US7131987B2 (en) * 2000-10-16 2006-11-07 Corium International, Inc. Microstructures and method for treating and conditioning skin which cause less irritation during exfoliation
US7108681B2 (en) 2000-10-16 2006-09-19 Corium International, Inc. Microstructures for delivering a composition cutaneously to skin
IL155583A0 (en) * 2000-10-26 2003-11-23 Alza Corp Transdermal drug delivery devices having coated microprotrusions
US6591133B1 (en) 2000-11-27 2003-07-08 Microlin Llc Apparatus and methods for fluid delivery using electroactive needles and implantable electrochemical delivery devices
US9302903B2 (en) * 2000-12-14 2016-04-05 Georgia Tech Research Corporation Microneedle devices and production thereof
US7027478B2 (en) * 2000-12-21 2006-04-11 Biovalve Technologies, Inc. Microneedle array systems
PT1372708E (pt) 2001-02-13 2008-09-29 Us Gov Sec Army Vacina para imunização transcutânea
US6663820B2 (en) * 2001-03-14 2003-12-16 The Procter & Gamble Company Method of manufacturing microneedle structures using soft lithography and photolithography
WO2002074173A1 (en) * 2001-03-16 2002-09-26 Alza Corporation Method and apparatus for coating skin piercing microprojections
EP1381423A1 (de) * 2001-04-13 2004-01-21 Becton, Dickinson and Company Verfahren und vorrichtung zur intradermale abgabe von substanzen für systemischer absorption
EP3251722B1 (de) 2001-04-20 2020-06-17 ALZA Corporation Mikroprojektionsanordnung mit einer beschichtung, der ein vorteilhaftes mittel enthält und beschichtungsverfahren dafuer
WO2002085447A2 (en) * 2001-04-20 2002-10-31 Alza Corporation Microprojection array having a beneficial agent containing coating
US6591124B2 (en) 2001-05-11 2003-07-08 The Procter & Gamble Company Portable interstitial fluid monitoring system
US6840910B2 (en) 2001-08-01 2005-01-11 Johnson & Johnson Consumer Companies, Inc. Method of distributing skin care products
US6790179B2 (en) 2001-08-01 2004-09-14 Johnson & Johnson Consumer Companies, Inc. Method of examining and diagnosing skin health
US6855117B2 (en) 2001-08-01 2005-02-15 Johnson & Johnson Consumer Companies, Inc. Method of treating the skin of a subject
US7186235B2 (en) * 2001-06-08 2007-03-06 Becton, Dickinson And Company Device for manipulating a needle or abrader array and method of use
BR0210628A (pt) 2001-06-29 2004-08-10 Becton Dickinson Co Liberação intradérmica de vacinas e agentes terapêuticos genéticos via microcânula
US20050010193A1 (en) * 2002-05-06 2005-01-13 Laurent Philippe E. Novel methods for administration of drugs and devices useful thereof
AU2002327675A1 (en) * 2001-09-19 2003-04-01 Biovalve Technologies, Inc. Microneedles, microneedle arrays, and systems and methods relating to same
ATE498418T1 (de) * 2001-09-21 2011-03-15 Valeritas Inc Durch gasdruck betätigte mikronadel-anordnungen und damit zusammenhängende systeme und verfahren
JP4647863B2 (ja) * 2001-09-26 2011-03-09 テルモ株式会社 薬剤投与具及び薬剤投与装置
CA2500453A1 (en) * 2001-09-28 2003-04-03 Biovalve Technologies, Inc. Microneedle with membrane
CA2500452A1 (en) * 2001-09-28 2003-04-03 Biovalve Technologies, Inc. Switchable microneedle arrays and systems and methods relating to same
US6689100B2 (en) 2001-10-05 2004-02-10 Becton, Dickinson And Company Microdevice and method of delivering or withdrawing a substance through the skin of an animal
US7429258B2 (en) * 2001-10-26 2008-09-30 Massachusetts Institute Of Technology Microneedle transport device
KR100448469B1 (ko) * 2001-10-26 2004-09-13 신풍제약주식회사 항염증제의 경피 조성물 및 장치
US20040120964A1 (en) * 2001-10-29 2004-06-24 Mikszta John A. Needleless vaccination using chimeric yellow fever vaccine-vectored vaccines against heterologous flaviviruses
US7349733B2 (en) * 2001-11-02 2008-03-25 Ceramatel, Inc. Iontophoretic drug delivery systems
EP1485317A2 (de) * 2001-11-30 2004-12-15 Alza Corporation Verfahren und vorrichtungen zur herstellung von mikroprojektoranordnungen
CH696701A5 (de) * 2001-12-18 2007-10-15 Hoffmann La Roche Verfahren zum Testen eines Mittels auf dessen Fähigkeit, die Heparanaseaktivität zu hemmen.
WO2003066126A2 (en) * 2002-02-04 2003-08-14 Becton, Dickinson And Company Dermal access member
US7047069B2 (en) 2002-02-04 2006-05-16 Ceramatec, Inc. Iontophoretic fluid delivery device
US6775570B2 (en) 2002-02-04 2004-08-10 Ceramatec, Inc. Iontophoretic treatment device
JP4608187B2 (ja) * 2002-02-28 2011-01-05 リンテック株式会社 経皮吸収型製剤
US8116860B2 (en) * 2002-03-11 2012-02-14 Altea Therapeutics Corporation Transdermal porator and patch system and method for using same
US9918665B2 (en) 2002-03-11 2018-03-20 Nitto Denko Corporation Transdermal porator and patch system and method for using same
ES2673480T3 (es) 2002-03-26 2018-06-22 Becton, Dickinson And Company Dispositivo de suministro de fluido por etapas múltiples y método
US7115108B2 (en) 2002-04-02 2006-10-03 Becton, Dickinson And Company Method and device for intradermally delivering a substance
US7047070B2 (en) 2002-04-02 2006-05-16 Becton, Dickinson And Company Valved intradermal delivery device and method of intradermally delivering a substance to a patient
US6780171B2 (en) 2002-04-02 2004-08-24 Becton, Dickinson And Company Intradermal delivery device
CA2484265C (en) 2002-05-06 2012-08-07 Becton, Dickinson And Company Method and device for controlling drug pharmacokinetics
US20060264886A9 (en) * 2002-05-06 2006-11-23 Pettis Ronald J Method for altering insulin pharmacokinetics
US6945952B2 (en) 2002-06-25 2005-09-20 Theraject, Inc. Solid solution perforator for drug delivery and other applications
DE10228680A1 (de) * 2002-06-27 2004-01-22 Holden Development Limited, Tortola Grundlage für transdermale Formulierungen (PTF)
CA2490545A1 (en) * 2002-06-28 2004-01-08 Alza Corporation Transdermal drug delivery devices having coated microprotrusions
AU2003251831B2 (en) 2002-07-19 2009-06-11 3M Innovative Properties Company Microneedle devices and microneedle delivery apparatus
US7250037B2 (en) * 2002-07-22 2007-07-31 Becton, Dickinson And Company Patch-like infusion device
TW200409657A (en) * 2002-08-08 2004-06-16 Alza Corp Transdermal vaccine delivery device having coated microprotrusions
WO2004020015A2 (en) 2002-08-29 2004-03-11 Becton Dickinson And Company Microprotrusion arrays and methods for using same to deliver substances into tissue
CA2497086A1 (en) * 2002-08-30 2004-03-11 Becton, Dickinson And Company Method of controlling pharmacokinetics of immunomodulatory compounds
AU2003275311A1 (en) * 2002-09-16 2004-04-30 Sung-Yun Kwon Solid micro-perforators and methods of use
EP1590033A2 (de) * 2002-09-30 2005-11-02 Alza Corporation Wirkstoffabgabesystem mit vasokonstriktor enthaltenden überzogenen mikroprojektionen
AU2003287073B2 (en) * 2002-10-11 2009-01-08 Becton, Dickinson And Company System and method for initiating and maintaining continuous, long-term control of a concentration of a substance in a patient using a feedback or model-based controller coupled to a single-needle or multi-needle intradermal (ID) delivery device
AR042815A1 (es) * 2002-12-26 2005-07-06 Alza Corp Dispositivo de suministro de agente activo que tiene miembros compuestos
EP1594484A2 (de) * 2003-02-17 2005-11-16 Cipla Ltd. Pharmazeutisches pflaster
US7578954B2 (en) 2003-02-24 2009-08-25 Corium International, Inc. Method for manufacturing microstructures having multiple microelements with through-holes
BRPI0411428A (pt) * 2003-06-13 2006-07-25 Becton Dickinson Co distribuição intradérmica de agentes biologicamente ativos
US20050123507A1 (en) * 2003-06-30 2005-06-09 Mahmoud Ameri Formulations for coated microprojections having controlled solubility
WO2005004729A1 (en) * 2003-06-30 2005-01-20 Alza Corporation Method for coating skin piercing microprojections
MXPA06000281A (es) 2003-06-30 2006-07-03 Johnson & Johnson Formulaciones para microproyecciones revestidas que contienen contraiones no volatiles.
AR044985A1 (es) * 2003-07-02 2005-10-12 Alza Corp Metodo y parche de inmunizacion por disposicion de microproyeccion
WO2005007020A2 (en) 2003-07-03 2005-01-27 Corium International, Inc. Wound dressing, ingredient delivery device and iv hold-down, and method relating to same
BRPI0413354A (pt) * 2003-08-04 2006-10-10 Alza Corp método e dispositivo para intensificar fluxo de agente transdérmico
MXPA06001467A (es) * 2003-08-12 2006-05-15 Becton Dickinson Co Dispositivo de infusion similar a un parche.
JP2007503268A (ja) 2003-08-25 2007-02-22 スリーエム イノベイティブ プロパティズ カンパニー 免疫応答修飾化合物の送達
US20050180952A1 (en) * 2003-08-26 2005-08-18 Pettis Ronald J. Methods for intradermal delivery of therapeutics agents
CN101415443A (zh) * 2003-10-23 2009-04-22 阿尔扎公司 涂覆微喷射体的稳定dna组合物
US8016811B2 (en) 2003-10-24 2011-09-13 Altea Therapeutics Corporation Method for transdermal delivery of permeant substances
US20050089554A1 (en) * 2003-10-24 2005-04-28 Cormier Michel J. Apparatus and method for enhancing transdermal drug delivery
US20050106226A1 (en) * 2003-10-24 2005-05-19 Cormier Michel J. Pretreatment method and system for enhancing transdermal drug delivery
WO2005044139A2 (en) * 2003-10-28 2005-05-19 Alza Corporation Method and apparatus for reducing the incidence of tobacco use
CN1897883A (zh) * 2003-10-28 2007-01-17 阿尔扎公司 通过涂覆的微喷射体释放治疗用肽和蛋白的聚合物缀合物
ATE539687T1 (de) * 2003-10-31 2012-01-15 Alza Corp Selbstbetätigter applikator für eine mikroprojektionsanordnung
EP1682012A4 (de) * 2003-11-13 2008-09-24 Alza Corp Zusammensetzung und gerät zur transdermalen abgabe
MXPA06005509A (es) * 2003-11-13 2007-05-23 Johnson & Johnson Sistema y metodo para distribucion transdermica.
WO2005051455A2 (en) * 2003-11-21 2005-06-09 Alza Corporation Ultrasound assisted transdermal vaccine delivery method and system
IL159273A0 (en) * 2003-12-09 2004-06-01 Transpharma Medical Ltd Transdermal delivery system for sustained release of polypeptides
US8017145B2 (en) * 2003-12-22 2011-09-13 Conopco, Inc. Exfoliating personal care wipe article containing an array of projections
JP2007516781A (ja) * 2003-12-29 2007-06-28 スリーエム イノベイティブ プロパティズ カンパニー 医療用具および該医療用具を含むキット
US20070191761A1 (en) * 2004-02-23 2007-08-16 3M Innovative Properties Company Method of molding for microneedle arrays
WO2005091922A2 (en) * 2004-03-03 2005-10-06 Becton, Dickinson And Company Methods and devices for improving delivery of a substance to skin
WO2005094526A2 (en) 2004-03-24 2005-10-13 Corium International, Inc. Transdermal delivery device
KR20070011481A (ko) * 2004-04-13 2007-01-24 알자 코포레이션 다중 백신의 경피 전달용 기구 및 방법
WO2005115360A2 (en) * 2004-05-11 2005-12-08 Becton, Dickinson And Company Formulations of anti-pain agents and methods of using the same
AU2005244734A1 (en) 2004-05-13 2005-12-01 Alza Corporation Apparatus and method for transdermal delivery of parathyroid hormone agents
JP2008507590A (ja) * 2004-05-19 2008-03-13 アルザ コーポレイション 免疫活性剤を経皮送達するための方法及び配合物
ES2650188T3 (es) * 2004-06-10 2018-01-17 3M Innovative Properties Company Dispositivo y kit de aplicación de parches
US20060030811A1 (en) * 2004-08-03 2006-02-09 Wong Patrick S Method and device for enhancing transdermal agent flux
AR054300A1 (es) * 2004-08-10 2007-06-20 Alza Corp Aparato y sistema de microproyeccion con escaso potencial infeccioso
AU2005272700A1 (en) * 2004-08-11 2006-02-23 Alza Corporation Apparatus and method for transdermal delivery of natriuretic peptides
JPWO2006016647A1 (ja) * 2004-08-12 2008-05-01 久光製薬株式会社 マイクロニードル付き経皮薬物投与装置
AR050608A1 (es) * 2004-08-19 2006-11-08 Alza Corp Aparato y metodo para administracion transdermica de factores de crecimiento endotelial vascular
AU2005282401A1 (en) * 2004-09-08 2006-03-16 Alza Corporation Microprojection array with improved skin adhesion and compliance
AR050959A1 (es) * 2004-09-28 2006-12-06 Alza Corp Estabilizacion de agentes inmunologicamente activos adyuvados con alumbre
ITPD20040252A1 (it) * 2004-10-14 2005-01-14 Bidoia Sas Di Gianfranco Bidoi Irrigatore chirurgico
US8252320B2 (en) 2004-10-21 2012-08-28 Durect Corporation Transdermal delivery system for sufentanil
ATE471146T1 (de) 2004-10-21 2010-07-15 Durect Corp Transdermale verabreichungssysteme
US20060093658A1 (en) * 2004-10-26 2006-05-04 Gayatri Sathyan Apparatus and method for transdermal delivery of desmopressin
WO2006055802A1 (en) 2004-11-18 2006-05-26 3M Innovative Properties Company Microneedle array applicator and retainer
EP2388078B1 (de) 2004-11-18 2013-03-20 3M Innovative Properties Co. Verfahren zum Kontaktbeschichten einer Mikronadelanordnung
WO2006055795A1 (en) 2004-11-18 2006-05-26 3M Innovative Properties Company Low-profile microneedle array applicator
US8057842B2 (en) 2004-11-18 2011-11-15 3M Innovative Properties Company Method of contact coating a microneedle array
EP1827564B1 (de) * 2004-11-18 2015-07-29 3M Innovative Properties Company Maskierungsverfahren zum beschichten einer mikronadelanordnung
CN102358015A (zh) 2004-12-07 2012-02-22 3M创新有限公司 模制微型针的方法
JP2008529750A (ja) * 2005-02-16 2008-08-07 アルザ コーポレイション 生体適合性が改善されたマイクロプロジェクションアレイ
EP1853231A2 (de) * 2005-02-16 2007-11-14 Alza Corporation Vorrichtung und verfahren zur transdermalen zuführung von agentien auf erythropoetin-basis
WO2006108185A1 (en) 2005-04-07 2006-10-12 3M Innovative Properties Company System and method for tool feedback sensing
US20060253079A1 (en) * 2005-04-25 2006-11-09 Mcdonough Justin Stratum corneum piercing device
US20070270738A1 (en) * 2005-04-25 2007-11-22 Wu Jeffrey M Method of treating ACNE with stratum corneum piercing patch
US20080009802A1 (en) * 2005-04-25 2008-01-10 Danilo Lambino Method of treating acne with stratum corneum piercing device
US20060280645A1 (en) * 2005-06-02 2006-12-14 Scott Sellers Method for terminal sterilization of transdermal delivery devices
CN101189031A (zh) * 2005-06-02 2008-05-28 阿尔扎公司 透皮递送器械的最终消毒方法
TWI419717B (zh) * 2005-06-17 2013-12-21 Altea Therapeutics Corp 滲透傳送系統及其使用方法
CA2612307A1 (en) * 2005-06-21 2007-01-04 Alza Corporation Method and device for coating a continuous strip of microprojection members
WO2007002523A2 (en) 2005-06-24 2007-01-04 3M Innovative Properties Company Collapsible patch with microneedle array
AU2006261899B2 (en) 2005-06-27 2012-05-10 Kindeva Drug Delivery L.P. Microneedle cartridge assembly and method of applying
CA2613111C (en) * 2005-06-27 2015-05-26 3M Innovative Properties Company Microneedle array applicator device and method of array application
US20070025869A1 (en) * 2005-07-15 2007-02-01 Gordon John H Fluid Delivery Device
CA2629393C (en) * 2005-09-06 2014-06-10 Theraject, Inc. Solid solution perforator containing drug particle and/or drug-adsorbed particles
JP2009507576A (ja) * 2005-09-12 2009-02-26 アルザ コーポレイション 被膜可能な経皮送達微小突起アセンブリ
US20070066934A1 (en) * 2005-09-19 2007-03-22 Transport Pharmaceuticals, Inc. Electrokinetic delivery system and methods therefor
US20070185432A1 (en) * 2005-09-19 2007-08-09 Transport Pharmaceuticals, Inc. Electrokinetic system and method for delivering methotrexate
US20080262416A1 (en) * 2005-11-18 2008-10-23 Duan Daniel C Microneedle Arrays and Methods of Preparing Same
EP1948139A4 (de) * 2005-11-18 2012-04-04 3M Innovative Properties Co Überziehbare zusammensetzungen, daraus erhaltene überzüge und mikroanordnungen mit diesen überzügen
US7842008B2 (en) * 2005-11-21 2010-11-30 Becton, Dickinson And Company Intradermal delivery device
EP1962942A1 (de) * 2005-12-21 2008-09-03 3M Innovative Properties Company Mikronadelvorrichtungen
US7658728B2 (en) * 2006-01-10 2010-02-09 Yuzhakov Vadim V Microneedle array, patch, and applicator for transdermal drug delivery
JPWO2007091608A1 (ja) 2006-02-10 2009-07-02 久光製薬株式会社 マイクロニードル付き経皮薬物投与装置
US7981034B2 (en) 2006-02-28 2011-07-19 Abbott Diabetes Care Inc. Smart messages and alerts for an infusion delivery and management system
CN101466393A (zh) * 2006-03-15 2009-06-24 阿尔扎公司 用于经皮递送甲状旁腺激素药剂以治疗骨质减少的方法
US9119945B2 (en) 2006-04-20 2015-09-01 3M Innovative Properties Company Device for applying a microneedle array
WO2007127815A2 (en) * 2006-04-25 2007-11-08 Alza Corporation Microprojection array application with multilayered microprojection member for high drug loading
US20070293816A1 (en) * 2006-04-25 2007-12-20 Alza Corporation Microprojection Array Application with Grouped Microprojections for High Drug Loading
US20070276318A1 (en) * 2006-05-26 2007-11-29 Mit, Llp Iontosonic-microneedle applicator apparatus and methods
US20070282246A1 (en) * 2006-06-05 2007-12-06 Mit, Llp Iontosonic-microneedle biosensor apparatus and methods
US9119582B2 (en) * 2006-06-30 2015-09-01 Abbott Diabetes Care, Inc. Integrated analyte sensor and infusion device and methods therefor
KR100886633B1 (ko) * 2006-07-14 2009-03-04 호남석유화학 주식회사 전면부에 피부를 통해 체내로 전달하고자 하는 물질의 수용공간을 갖는 피부 침투용 미세 돌기 장치
US20090182306A1 (en) * 2006-07-21 2009-07-16 Georgia Tech Research Corporation Microneedle Devices and Methods of Drug Delivery or Fluid Withdrawal
US8206296B2 (en) 2006-08-07 2012-06-26 Abbott Diabetes Care Inc. Method and system for providing integrated analyte monitoring and infusion system therapy management
US8932216B2 (en) 2006-08-07 2015-01-13 Abbott Diabetes Care Inc. Method and system for providing data management in integrated analyte monitoring and infusion system
US20080147186A1 (en) * 2006-12-14 2008-06-19 Joshi Ashok V Electrochemical Implant For Delivering Beneficial Agents
EP2121111B1 (de) 2007-01-22 2018-03-14 Corium International, Inc. Applikator für mikronadelanordnung
US20080177219A1 (en) * 2007-01-23 2008-07-24 Joshi Ashok V Method for Iontophoretic Fluid Delivery
US8911749B2 (en) 2007-04-16 2014-12-16 Corium International, Inc. Vaccine delivery via microneedle arrays
EP2146689B1 (de) 2007-04-16 2020-08-12 Corium, Inc. Einen wirkstoff enthaltende lösungsmittel-gegossene mikronadelanordnungen
US8439861B2 (en) 2007-04-24 2013-05-14 Velcro Industries B.V. Skin penetrating touch fasteners
US8197844B2 (en) 2007-06-08 2012-06-12 Activatek, Inc. Active electrode for transdermal medicament administration
US8641618B2 (en) 2007-06-27 2014-02-04 Abbott Diabetes Care Inc. Method and structure for securing a monitoring device element
US8085151B2 (en) 2007-06-28 2011-12-27 Abbott Diabetes Care Inc. Signal converting cradle for medical condition monitoring and management system
WO2009023798A2 (en) 2007-08-14 2009-02-19 Fred Hutchinson Cancer Research Center Needle array assembly and method for delivering therapeutic agents
JP4381438B2 (ja) * 2007-09-05 2009-12-09 渡 渡邉 薬剤シート
US9037229B2 (en) * 2007-10-09 2015-05-19 Syneron Medical Ltd Magnetic patch coupling
KR101287351B1 (ko) 2007-12-05 2013-07-23 시네론 메디컬 리미티드 피부 치료장치용 캐리어
DE202009017814U1 (de) 2008-01-17 2010-07-01 Syneron Medical Ltd. Haarentfernungsgerät für die persönliche Anwendung
US8862223B2 (en) 2008-01-18 2014-10-14 Activatek, Inc. Active transdermal medicament patch and circuit board for same
JP2011509791A (ja) 2008-01-24 2011-03-31 シネロン メディカル リミテッド 脂肪組織治療の機器、装置および方法
KR100950584B1 (ko) * 2008-04-07 2010-04-01 주식회사로케트전기 전지 일체형 이온토포레시스 패치
AU2009249610B2 (en) * 2008-05-21 2014-01-16 Theraject, Inc. Method of manufacturing solid solution perforator patches and uses thereof
US8366600B2 (en) * 2008-06-19 2013-02-05 Nupathe Inc. Polyamine enhanced formulations for triptan compound iontophoresis
EP2334249B1 (de) 2008-09-21 2013-03-13 Syneron Medical Ltd. Verfahren und vorrichtung zur hautpflege
JP5550009B2 (ja) * 2008-11-14 2014-07-16 国立大学法人東京工業大学 イオントフォレシス用電極組成物の製造方法
US20100286600A1 (en) * 2009-05-08 2010-11-11 Bommannan D Bommi Transdermal patch device
US20130018279A1 (en) * 2009-09-01 2013-01-17 Pathway Genomics "blood sample collection apparatus and kits"
JP5827237B2 (ja) 2009-12-16 2015-12-02 ベクトン・ディキンソン・アンド・カンパニーBecton, Dickinson And Company 自己注射デバイス
CN102753221B (zh) 2009-12-16 2017-04-26 贝克顿·迪金森公司 自注射装置
ES2729928T3 (es) 2009-12-16 2019-11-07 Becton Dickinson Co Dispositivo de auto inyección
EP2512560B1 (de) 2009-12-16 2018-04-04 Becton, Dickinson and Company Selbstinjektionsvorrichtung
WO2011075100A1 (en) 2009-12-16 2011-06-23 Becton, Dickinson And Company Self-injection device
DK2512579T3 (en) 2009-12-16 2017-03-13 Becton Dickinson Co Self Injection Device
ES2719595T3 (es) 2010-05-04 2019-07-11 Corium Int Inc Método y dispositivo para la administración transdérmica de la hormona paratiroidea usando una matriz de microproyección
WO2011156373A1 (en) 2010-06-07 2011-12-15 Amgen Inc. Drug delivery device
WO2012030316A1 (en) 2010-09-02 2012-03-08 Becton, Dickinson And Company Self-injection device having needle cover with activation preventer
AU2011338530B2 (en) 2010-12-06 2017-06-15 Follica, Inc. Methods for treating baldness and promoting hair growth
CN103889497A (zh) 2011-10-20 2014-06-25 考司美德制药株式会社 微针熔着法
SG11201401851UA (en) 2011-10-28 2014-05-29 Presage Biosciences Inc Methods for drug delivery
US8632501B2 (en) * 2012-03-01 2014-01-21 Joseph Wayne Kraft Device for the rapid injection of local anesthesia through a plurality of needles
US11052231B2 (en) 2012-12-21 2021-07-06 Corium, Inc. Microarray for delivery of therapeutic agent and methods of use
CN109621083B (zh) 2013-02-28 2022-03-22 索伦托治疗有限公司 药物递送装置
WO2014132239A1 (en) 2013-02-28 2014-09-04 Kimberly-Clark Worldwide, Inc. Drug delivery device
RU2674083C2 (ru) 2013-03-12 2018-12-04 Кориум Интернэшнл, Инк. Аппликаторы с микровыступами
ES2761580T3 (es) 2013-03-15 2020-05-20 Corium Inc Micromatrices para suministro de agente terapéutico, métodos de uso y métodos de fabricación
EP2968116A1 (de) 2013-03-15 2016-01-20 Corium International, Inc. Mikroarray mit polymerfreien mikrostrukturen, verfahren zur herstellung und verfahren zur verwendung
WO2014150285A2 (en) 2013-03-15 2014-09-25 Corium International, Inc. Multiple impact microprojection applicators and methods of use
AU2014233695A1 (en) 2013-03-15 2015-10-01 Corium International, Inc. Microarray for delivery of therapeutic agent and methods of use
EP3027263A1 (de) 2013-07-30 2016-06-08 ZP Opco, Inc. Flacher mikronadelfeldapplikator
US9889290B2 (en) 2013-08-27 2018-02-13 Halo Neuro, Inc. Electrode system for electrical stimulation
KR20160046887A (ko) 2013-08-27 2016-04-29 헤일로우 뉴로 아이엔씨. 전기 자극을 사용자에게 제공하기 위한 방법 및 시스템
US9782585B2 (en) 2013-08-27 2017-10-10 Halo Neuro, Inc. Method and system for providing electrical stimulation to a user
US9486618B2 (en) 2013-08-27 2016-11-08 Halo Neuro, Inc. Electrode system for electrical stimulation
CA2955940A1 (en) * 2014-07-25 2016-01-28 Full Power Aed, Llc Device, system, method and kit for preparing skin
WO2016036866A1 (en) 2014-09-04 2016-03-10 Corium International, Inc. Microstructure array, methods of making, and methods of use
US10857093B2 (en) 2015-06-29 2020-12-08 Corium, Inc. Microarray for delivery of therapeutic agent, methods of use, and methods of making
EP3368146B1 (de) 2015-10-26 2021-04-07 Halo Neuro, Inc. Elektrodenpositionierungssystem
US10315033B2 (en) 2016-02-08 2019-06-11 Halo Neuro, Inc. Method and system for improving provision of electrical stimulation
US10485443B2 (en) 2016-06-20 2019-11-26 Halo Neuro, Inc. Electrical interface system
CN109293759A (zh) * 2017-01-17 2019-02-01 李露青 一种抗癌活性肽变体及其应用
WO2018165481A1 (en) 2017-03-08 2018-09-13 Halo Neuro, Inc. System for electrical stimulation
US10507324B2 (en) 2017-11-17 2019-12-17 Halo Neuro, Inc. System and method for individualizing modulation
US11583633B2 (en) 2018-04-03 2023-02-21 Amgen Inc. Systems and methods for delayed drug delivery
CN113877055A (zh) * 2021-08-10 2022-01-04 中国人民解放军军事科学院军事医学研究院 辐射敏感可穿戴药物控释系统

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL19087C (de) * 1919-05-17
US3136314A (en) * 1960-08-01 1964-06-09 Kravitz Harvey Vaccinating devices
DE2643130C2 (de) * 1976-09-24 1982-12-23 "Perseus" GmbH Medizintechnik Biologische Erzeugnisse und Edition, 8000 München Akupunktur-Elektrode
EP0060451B1 (de) * 1981-03-06 1986-09-17 Medtronic, Inc. Iontophorese-Elektrode
US4473083A (en) * 1981-12-14 1984-09-25 Maganias Nicholas H Device and method for allergy testing
US4622031A (en) * 1983-08-18 1986-11-11 Drug Delivery Systems Inc. Indicator for electrophoretic transcutaneous drug delivery device
CA1262564A (en) * 1983-09-01 1989-10-31 Minoru Sasaki Iontophoresis device
EP0308572B1 (de) * 1983-09-01 1995-11-08 Hisamitsu Pharmaceutical Co., Inc. Iontophoresegerät
JPS61259679A (ja) * 1985-05-14 1986-11-17 日東電工株式会社 イオントフオレ−ゼ生体電極用基剤組成物
US4722726A (en) * 1986-02-12 1988-02-02 Key Pharmaceuticals, Inc. Method and apparatus for iontophoretic drug delivery
JPS62268570A (ja) * 1986-05-19 1987-11-21 株式会社アドバンス イオントフオレ−ゼ用電極
JPS63102768A (ja) * 1986-10-20 1988-05-07 山之内製薬株式会社 イオントフオレ−シス用の新規プラスタ−構造体
US4940456A (en) * 1987-02-10 1990-07-10 Dan Sibalis Electrolytic transdermal delivery of proteins
US4878892A (en) * 1987-02-10 1989-11-07 Drug Delivery Systems Inc. Electrolytic transdermal delivery of polypeptides
AU614092B2 (en) * 1987-09-11 1991-08-22 Paul Max Grinwald Improved method and apparatus for enhanced drug permeation of skin
US4927408A (en) * 1988-10-03 1990-05-22 Alza Corporation Electrotransport transdermal system
EP0429842B1 (de) * 1989-10-27 1996-08-28 Korea Research Institute Of Chemical Technology Vorrichtung zur transdermalen Applikation von Protein- oder Peptid-Medikamenten
US5084006A (en) * 1990-03-30 1992-01-28 Alza Corporation Iontopheretic delivery device

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Publication number Publication date
EP0509122B1 (de) 1996-10-02
ES2093652T3 (es) 1997-01-01
EP0429842A2 (de) 1991-06-05
DE69122494D1 (de) 1996-11-07
DK0509122T3 (da) 1996-11-18
EP0727221A2 (de) 1996-08-21
EP0429842A3 (en) 1992-01-22
JPH0614980B2 (ja) 1994-03-02
EP0429842B1 (de) 1996-08-28
US5250023A (en) 1993-10-05
JPH03151982A (ja) 1991-06-28
EP0727221A3 (de) 1996-10-23
EP0509122A1 (de) 1992-10-21

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