DE69125380T2 - Durch reduktion orthogonal entfernbare hydroxylschutzgruppen und ihre verwendung in der chemischen synthese von oligonukleotiden - Google Patents
Durch reduktion orthogonal entfernbare hydroxylschutzgruppen und ihre verwendung in der chemischen synthese von oligonukleotidenInfo
- Publication number
- DE69125380T2 DE69125380T2 DE69125380T DE69125380T DE69125380T2 DE 69125380 T2 DE69125380 T2 DE 69125380T2 DE 69125380 T DE69125380 T DE 69125380T DE 69125380 T DE69125380 T DE 69125380T DE 69125380 T2 DE69125380 T2 DE 69125380T2
- Authority
- DE
- Germany
- Prior art keywords
- chemical synthesis
- hydroxyl
- oligonucleotides
- protective groups
- protecting groups
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
- C07H19/10—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US07/558,881 US5430138A (en) | 1990-07-27 | 1990-07-27 | Hydroxyl-protecting groups attached to cytidine nucleotide compounds which are orthogonally removable |
PCT/US1991/005227 WO1992002533A1 (en) | 1990-07-27 | 1991-07-24 | Hydroxyl-protecting groups orthogonally removable by reduction and their use in the chemical synthesis of oligonucleotides |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69125380D1 DE69125380D1 (de) | 1997-04-30 |
DE69125380T2 true DE69125380T2 (de) | 1997-08-28 |
Family
ID=24231370
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69125380T Expired - Lifetime DE69125380T2 (de) | 1990-07-27 | 1991-07-24 | Durch reduktion orthogonal entfernbare hydroxylschutzgruppen und ihre verwendung in der chemischen synthese von oligonukleotiden |
Country Status (7)
Country | Link |
---|---|
US (2) | US5430138A (de) |
EP (1) | EP0543906B1 (de) |
JP (1) | JP3081882B2 (de) |
AT (1) | ATE150760T1 (de) |
CA (1) | CA2088255A1 (de) |
DE (1) | DE69125380T2 (de) |
WO (1) | WO1992002533A1 (de) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE10133779A1 (de) * | 2001-07-16 | 2003-02-06 | Chemogenix Gmbh | Multimerpolynukleotidsynthese |
Families Citing this family (31)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5430138A (en) * | 1990-07-27 | 1995-07-04 | Chiron Corporation | Hydroxyl-protecting groups attached to cytidine nucleotide compounds which are orthogonally removable |
TW323284B (de) * | 1992-03-23 | 1997-12-21 | Novartis Ag | |
US6020482A (en) * | 1992-05-25 | 2000-02-01 | Gosselin; Gilles | Phosphotriester type biologically active compounds |
US5770725A (en) * | 1992-05-25 | 1998-06-23 | Gosselin; Gilles | Phosphotriester type biologically active compounds |
FR2692265B1 (fr) | 1992-05-25 | 1996-11-08 | Centre Nat Rech Scient | Composes biologiquement actifs de type phosphotriesters. |
US5849905A (en) * | 1994-11-23 | 1998-12-15 | Centre National De La Recherche Scientifique | Biologically active phosphotriester-type nucleosides and methods for preparing same |
US5955591A (en) * | 1993-05-12 | 1999-09-21 | Imbach; Jean-Louis | Phosphotriester oligonucleotides, amidites and method of preparation |
US5597909A (en) * | 1994-08-25 | 1997-01-28 | Chiron Corporation | Polynucleotide reagents containing modified deoxyribose moieties, and associated methods of synthesis and use |
US5639875A (en) * | 1995-02-01 | 1997-06-17 | Hybridon, Inc. | Methods for H-phosphonate syntheis of oligonucleotides using triphosgene |
JP2002515730A (ja) * | 1995-10-16 | 2002-05-28 | カイロン コーポレイション | 遺伝子発現を変調する因子のスクリーニング方法 |
US6828435B2 (en) | 1996-04-17 | 2004-12-07 | Hk Pharmaceuticals, Inc. | Combinatorial protecting group strategy for multifunctional molecules |
AU6659298A (en) | 1997-02-18 | 1998-09-08 | Thomas Jefferson University | Compositions that bind to pancreatic cancer cells and methods of using the same |
US6120995A (en) * | 1997-08-07 | 2000-09-19 | Thomas Jefferson University | Compositions that specifically bind to colorectal cancer cells and methods of using the same |
US7135333B1 (en) | 1997-08-07 | 2006-11-14 | Thomas Jefferson University | Compositions that specifically bind to colorectal cancer cells and methods of using the same |
AU6270499A (en) * | 1998-09-29 | 2000-04-17 | Phylos, Inc. | Synthesis of codon randomized nucleic acids |
WO2000056749A1 (en) | 1999-03-24 | 2000-09-28 | The Government Of The United States Of America, Represented By The Secretary, Department Of Health And Human Services | N-acylphosphoramidites and their use in oligonucleotide synthesis |
WO2001073133A1 (en) | 2000-03-27 | 2001-10-04 | Thomas Jefferson University | Compositions and methods for identifying and targeting cancer cells |
AU2001292728A1 (en) * | 2000-09-18 | 2002-03-26 | Thomas Jefferson University | Compositions and methods for identifying and targeting stomach and esophageal cancer cells |
US6932943B1 (en) | 2001-01-26 | 2005-08-23 | Third Wave Technologies | Nucleic acid synthesizers |
US7435390B2 (en) * | 2001-01-26 | 2008-10-14 | Third Wave Technologies, Inc. | Nucleic acid synthesizers |
AU2002353001A1 (en) * | 2001-12-03 | 2003-06-17 | The Government Of The United States Of America, Represented By The Secretary Of The Department Of He | Thermolabile hydroxyl protecting groups and methods of use |
AUPR975201A0 (en) * | 2001-12-24 | 2002-01-24 | Unisearch Limited | Enzymatic redox labelling of nucleic acids |
DE10247790A1 (de) * | 2002-10-14 | 2004-04-22 | Chemogenix Gmbh | Verfahren zur Herstellung von Oligonukleotidkonjugaten |
JP2006516099A (ja) * | 2002-12-23 | 2006-06-22 | ダイナバックス テクノロジーズ コーポレイション | 分枝状の免疫調節化合物及び該化合物の使用方法 |
US7595304B2 (en) | 2003-04-13 | 2009-09-29 | Enzon Pharmaceuticals, Inc. | Polymeric oligonucleotide prodrugs |
US9809824B2 (en) * | 2004-12-13 | 2017-11-07 | The United States Of America, Represented By The Secretary, Department Of Health And Human Services | CpG oligonucleotide prodrugs, compositions thereof and associated therapeutic methods |
EP1899361B1 (de) | 2005-05-26 | 2013-12-11 | Luminex Corporation | Reagens für die verbesserte synthese von isoguanosinhaltigen oligonukleotiden |
KR100834812B1 (ko) | 2006-07-04 | 2008-06-05 | 삼성전자주식회사 | 이동통신 시스템에서 세션 이동 횟수를 줄이는 핸드오프를위한 장치 및 방법 |
AU2007281709B2 (en) | 2006-08-11 | 2013-04-18 | Rutgers, The State University Of New Jersey | Dual-sensitizer-containing luminescent compounds, conjugates, and uses thereof |
US9221759B2 (en) | 2010-01-13 | 2015-12-29 | Rutgers, The State University Of New Jersey | Fluorophore chelated lanthanide luminescent probes with improved quantum efficiency |
EP3972983A4 (de) * | 2019-05-17 | 2023-05-24 | Ionis Pharmaceuticals, Inc. | Synthese oligomerer verbindungen mit einem phosphorothioatdiester und phosphatdiesterbindungen |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5118802A (en) * | 1983-12-20 | 1992-06-02 | California Institute Of Technology | DNA-reporter conjugates linked via the 2' or 5'-primary amino group of the 5'-terminal nucleoside |
US4843122A (en) * | 1984-01-30 | 1989-06-27 | Enzo Biochem, Inc. | Detectable molecules, method of preparation and use |
EP0180614B1 (de) * | 1984-04-18 | 1990-03-07 | Whitby Research Incorporated | Cardio-vasodilatatore n-6-substituierte adenosine |
US5367066A (en) * | 1984-10-16 | 1994-11-22 | Chiron Corporation | Oligonucleotides with selectably cleavable and/or abasic sites |
US5093232A (en) * | 1985-12-11 | 1992-03-03 | Chiron Corporation | Nucleic acid probes |
US4910300A (en) * | 1985-12-11 | 1990-03-20 | Chiron Corporation | Method for making nucleic acid probes |
US4837311A (en) * | 1987-06-22 | 1989-06-06 | Hoffman-La Roche Inc. | Anti-retroviral compounds |
CA1339351C (en) * | 1987-10-15 | 1997-08-26 | Michael S. Urdea | Nucleic acid multimers and amplified nucleic acid hybridization assays using same |
US5430138A (en) * | 1990-07-27 | 1995-07-04 | Chiron Corporation | Hydroxyl-protecting groups attached to cytidine nucleotide compounds which are orthogonally removable |
-
1990
- 1990-07-27 US US07/558,881 patent/US5430138A/en not_active Expired - Lifetime
-
1991
- 1991-07-24 DE DE69125380T patent/DE69125380T2/de not_active Expired - Lifetime
- 1991-07-24 AT AT91915182T patent/ATE150760T1/de not_active IP Right Cessation
- 1991-07-24 CA CA002088255A patent/CA2088255A1/en not_active Abandoned
- 1991-07-24 EP EP91915182A patent/EP0543906B1/de not_active Expired - Lifetime
- 1991-07-24 WO PCT/US1991/005227 patent/WO1992002533A1/en active IP Right Grant
- 1991-07-24 JP JP03513745A patent/JP3081882B2/ja not_active Expired - Fee Related
-
1995
- 1995-04-13 US US08/421,798 patent/US5703218A/en not_active Expired - Lifetime
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE10133779A1 (de) * | 2001-07-16 | 2003-02-06 | Chemogenix Gmbh | Multimerpolynukleotidsynthese |
Also Published As
Publication number | Publication date |
---|---|
ATE150760T1 (de) | 1997-04-15 |
US5703218A (en) | 1997-12-30 |
EP0543906B1 (de) | 1997-03-26 |
EP0543906A1 (de) | 1993-06-02 |
CA2088255A1 (en) | 1992-01-28 |
DE69125380D1 (de) | 1997-04-30 |
US5430138A (en) | 1995-07-04 |
WO1992002533A1 (en) | 1992-02-20 |
JP3081882B2 (ja) | 2000-08-28 |
EP0543906A4 (en) | 1993-07-14 |
JPH05509317A (ja) | 1993-12-22 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition | ||
8327 | Change in the person/name/address of the patent owner |
Owner name: CHIRON DIAGNOSTICS CORP. (N.D.GES.D. STAATES DELAW |
|
8327 | Change in the person/name/address of the patent owner |
Owner name: SIEMENS HEALTHCARE DIAGNOSTICS INC. (N.D.GES.D, US |
|
8328 | Change in the person/name/address of the agent |
Representative=s name: MAIER, D., DIPL.-ING. UNIV., PAT.-ASS., 81739 MUEN |