DE69129193D1 - Triterpenderivat - Google Patents

Triterpenderivat

Info

Publication number
DE69129193D1
DE69129193D1 DE69129193T DE69129193T DE69129193D1 DE 69129193 D1 DE69129193 D1 DE 69129193D1 DE 69129193 T DE69129193 T DE 69129193T DE 69129193 T DE69129193 T DE 69129193T DE 69129193 D1 DE69129193 D1 DE 69129193D1
Authority
DE
Germany
Prior art keywords
hydrogen
formula
antiendotheline
chem
aryl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69129193T
Other languages
English (en)
Other versions
DE69129193T2 (de
Inventor
Masafumi Fujimoto
Kensuke Sakurai
Shinichi Mihara
Miharu Nakamura
Toshiro Konoike
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Shionogi and Co Ltd
Original Assignee
Shionogi and Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Shionogi and Co Ltd filed Critical Shionogi and Co Ltd
Publication of DE69129193D1 publication Critical patent/DE69129193D1/de
Application granted granted Critical
Publication of DE69129193T2 publication Critical patent/DE69129193T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J63/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by expansion of only one ring by one or two atoms
    • C07J63/008—Expansion of ring D by one atom, e.g. D homo steroids
DE69129193T 1991-01-29 1991-12-13 Triterpenderivat Expired - Lifetime DE69129193T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2937291 1991-01-29
PCT/JP1991/001707 WO1992012991A1 (en) 1991-01-29 1991-12-13 Triterpene derivative

Publications (2)

Publication Number Publication Date
DE69129193D1 true DE69129193D1 (en) 1998-05-07
DE69129193T2 DE69129193T2 (de) 1998-07-30

Family

ID=12274319

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69129193T Expired - Lifetime DE69129193T2 (de) 1991-01-29 1991-12-13 Triterpenderivat

Country Status (8)

Country Link
US (1) US5248807A (de)
EP (1) EP0526642B1 (de)
JP (1) JP2950616B2 (de)
AT (1) ATE164588T1 (de)
DE (1) DE69129193T2 (de)
DK (1) DK0526642T3 (de)
ES (1) ES2115665T3 (de)
WO (1) WO1992012991A1 (de)

Families Citing this family (50)

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US5962490A (en) * 1987-09-25 1999-10-05 Texas Biotechnology Corporation Thienyl-, furyl- and pyrrolyl-sulfonamides and derivatives thereof that modulate the activity of endothelin
US5736509A (en) * 1990-12-14 1998-04-07 Texas Biotechnology Corporation Cyclic peptide surface feature mimics of endothelin
AU4376893A (en) * 1992-05-19 1993-12-13 Immunopharmaceutics, Inc. Compounds that modulate endothelin activity
US5352800A (en) * 1993-03-11 1994-10-04 Merck & Co., Inc. Process for the production of a novel endothelin antagonist
US5374638A (en) * 1993-03-19 1994-12-20 Merck & Co., Inc. Six membered ring fused imidazoles substituted with phenoxyphenylacetic acid derivatives used to treat asthma
US5767310A (en) * 1993-03-19 1998-06-16 Merck & Co., Inc. Phenoxyphenylacetic acid derivatives
US5334598A (en) * 1993-03-19 1994-08-02 Merck & Co., Inc. Six-membered ring fused imidazoles substituted with phenoxyphenylacetic acid derivatives
US5420133A (en) * 1993-03-19 1995-05-30 Merck & Co., Inc. Quinazolinones substituted with phenoxyphenylacetic acid derivatives
US5401745A (en) * 1993-03-19 1995-03-28 Merck & Co., Inc. Quinazolinones substituted with phenoxyphenylacetic acid derivatives
US5527890A (en) * 1993-04-16 1996-06-18 Glycomed Incorporated Derivatives of triterpenoid acids and uses thereof
EP0626174A3 (de) 1993-04-21 1996-01-03 Takeda Chemical Industries Ltd Verfahren und Zusammensetzung für die Prophylaxe und/oder Behandlung von Organunterfunktion.
US6376523B1 (en) 1994-05-20 2002-04-23 Texas Biotechnology Corporation Benzenesulfonamides and the use thereof to modulate the activity of endothelin
US6342610B2 (en) 1993-05-20 2002-01-29 Texas Biotechnology Corp. N-aryl thienyl-, furyl-, and pyrrolyl-sulfonamides and derivatives thereof that modulate the activity of endothelin
US6613804B2 (en) 1993-05-20 2003-09-02 Encysive Pharmaceuticals, Inc. Biphenylsulfonamides and derivatives thereof that modulate the activity of endothelin
US6541498B2 (en) 1993-05-20 2003-04-01 Texas Biotechnology Benzenesulfonamides and the use thereof to modulate the activity of endothelin
US6030991A (en) * 1993-05-20 2000-02-29 Texas Biotechnology Corp. Benzenesulfonamides and the use thereof to modulate the activity of endothelin
ES2094622T3 (es) 1993-06-11 1997-01-16 Shionogi & Co Derivados triterpenos y antagonistas del receptor de endotelina que los contiene.
US5686478A (en) * 1993-07-20 1997-11-11 Merck & Co. Inc. Endothelin antagonists
CN1034334C (zh) * 1993-08-14 1997-03-26 贵州省中医研究所 齐酞酸钠及其药物组合物
US5492917A (en) * 1993-09-29 1996-02-20 Merck & Co., Inc. Endothelin antagonists incorporating a cyclobutane
US5559135A (en) * 1994-09-14 1996-09-24 Merck & Co., Inc. Endothelin antagonists bearing pyridyl amides
US5538991A (en) * 1994-09-14 1996-07-23 Merck & Co., Inc. Endothelin antagonists bearing 5-membered heterocyclic amides
DK0838223T3 (da) * 1995-06-02 2003-11-17 Shionogi & Co Hjerneødeminhibitor
US5977117A (en) * 1996-01-05 1999-11-02 Texas Biotechnology Corporation Substituted phenyl compounds and derivatives thereof that modulate the activity of endothelin
US5958905A (en) * 1996-03-26 1999-09-28 Texas Biotechnology Corporation Phosphoramidates, phosphinic amides and related compounds and the use thereof to modulate the activity of endothelin
US5804585A (en) * 1996-04-15 1998-09-08 Texas Biotechnology Corporation Thieno-pyridine sulfonamides derivatives thereof and related compounds that modulate the activity of endothelin
ES2241133T3 (es) 1997-04-28 2005-10-16 Encysive Pharmaceuticals Inc. Sulfamidas para el tratamiento de los trastornos inducidos por la endotelina.
US5783705A (en) 1997-04-28 1998-07-21 Texas Biotechnology Corporation Process of preparing alkali metal salys of hydrophobic sulfonamides
US6326507B1 (en) 1998-06-19 2001-12-04 Trustees Of Dartmouth College Therapeutic compounds and methods of use
US7566452B1 (en) 1999-05-04 2009-07-28 New York University Cancer treatment with endothelin receptor antagonists
IL150311A0 (en) 1999-12-31 2002-12-01 Texas Biotechnology Corp Sulfonamides and derivatives thereof that modulate the activity of endothelin
JP4437923B2 (ja) * 2002-03-22 2010-03-24 塩野義製薬株式会社 トリテルペン誘導体の製造方法
US20050175667A1 (en) * 2004-02-10 2005-08-11 Wenda Carlyle Use of endothelin antagonists to prevent restenosis
JP4827189B2 (ja) 2004-05-14 2011-11-30 塩野義製薬株式会社 過酸化水素およびタングステン触媒を用いたアルコールの酸化反応
KR20070087670A (ko) * 2004-12-21 2007-08-28 다우 글로벌 테크놀로지스 인크. 폴리프로필렌-기재의 접착제 조성물
WO2007103727A2 (en) * 2006-03-03 2007-09-13 Savipu Pharmaceuticals Triterpene derivatives for the treatment of cancer and inflammatory disease by inhibition of nf-kb
US7323476B2 (en) * 2006-03-03 2008-01-29 Savipu Pharmaceuticals Myriceric acid derivatives for the treatment of cancer, cardiovascular and inflammatory diseases
US20070207989A1 (en) * 2006-03-03 2007-09-06 Savipu Pharmaceuticals Diterpene derivatives for the treatment of cardiovascular, cancer and inflammatory diseases
MX2008011844A (es) * 2006-03-13 2008-10-02 Encysive Pharmaceuticals Inc Formulaciones de sitaxsentano de sodio.
EP1996162A2 (de) * 2006-03-13 2008-12-03 Encysive Pharmaceuticals, Inc Verfahren und zusammensetzungen zur behandlung von diastolischer herzinsuffizienz
US20070243273A1 (en) * 2006-04-12 2007-10-18 Savipu Pharmaceuticals Reduction of the Deleterious Effects of Tobacco Smoking
US20080026061A1 (en) * 2006-06-22 2008-01-31 Reichwein John F Crystalline N-(4-chloro-3-methyl-5-isoxazolyl)-2-[2-methyl-4.5-(methylenedioxy)phenylacetyl]-thiophene-3-sulfonamide
US20080017207A1 (en) * 2006-07-18 2008-01-24 Savipu Pharmaceuticals Reduction of the Deleterious Effects of Tobacco Smoking by the Induction of Phase 2 Enzymes by Nerf2
US20080187608A1 (en) * 2007-02-05 2008-08-07 Savipu Pharmaceuticals Enriched fractions from clary sage for the treatment of cancer, cardiovascular and inflammatory diseases
US20090022821A1 (en) * 2007-07-17 2009-01-22 Inderjit Kumar Dev Compositions from wax myrtle for the treatment of cancer, cardiovascular and inflammatory diseases
RS58486B1 (sr) 2008-01-11 2019-04-30 Reata Pharmaceuticals Inc Sintetički triterpenoidi i metode njihove upotrebe u tretmanu bolesti
BRPI0911208B1 (pt) 2008-04-18 2021-05-25 Reata Pharmaceuticals, Inc Compostos moduladores inflamatórios antioxidantes, seu uso, e composição farmacêutica
CN103342729B (zh) * 2013-03-26 2016-09-14 中国科学院上海药物研究所 咖啡酰基取代的五环三萜类衍生物及其用途
CA3042123A1 (en) 2016-11-08 2018-05-17 Reata Pharmaceuticals, Inc. Methods of treating alport syndrome using bardoxolone methyl or analogs thereof
AU2019205091A1 (en) 2018-01-04 2020-04-30 Amryt Research Limited Betulin-containing birch bark extracts and their formulation

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FI77669C (fi) * 1983-04-13 1989-04-10 Ciba Geigy Ag 20-spiroxaner och analoger, som innehaoller en oeppen ring e, foerfarande foer deras framstaellning samt dessa innehaollande farmaceutiska preparat.
JPS63222119A (ja) * 1987-03-10 1988-09-16 Rooman Kogyo:Kk 肝臓疾患用剤
US4997836A (en) * 1988-11-11 1991-03-05 Takeda Chemical Industries, Ltd. Trisubstituted piperazine compounds, their production and use

Also Published As

Publication number Publication date
DK0526642T3 (da) 1998-10-19
EP0526642A4 (de) 1994-02-09
EP0526642A1 (de) 1993-02-10
WO1992012991A1 (en) 1992-08-06
ES2115665T3 (es) 1998-07-01
DE69129193T2 (de) 1998-07-30
US5248807A (en) 1993-09-28
ATE164588T1 (de) 1998-04-15
EP0526642B1 (de) 1998-04-01
JP2950616B2 (ja) 1999-09-20

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition