DE69132370D1 - Methode zur herstellung von eicosapentansäuren - Google Patents

Methode zur herstellung von eicosapentansäuren

Info

Publication number
DE69132370D1
DE69132370D1 DE69132370T DE69132370T DE69132370D1 DE 69132370 D1 DE69132370 D1 DE 69132370D1 DE 69132370 T DE69132370 T DE 69132370T DE 69132370 T DE69132370 T DE 69132370T DE 69132370 D1 DE69132370 D1 DE 69132370D1
Authority
DE
Germany
Prior art keywords
diatoms
epa
pct
depletion
silicate
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69132370T
Other languages
English (en)
Other versions
DE69132370T2 (de
Inventor
John Kyle
Raymond Gladue
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Martek Corp
Original Assignee
Martek Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Martek Corp filed Critical Martek Corp
Application granted granted Critical
Publication of DE69132370D1 publication Critical patent/DE69132370D1/de
Publication of DE69132370T2 publication Critical patent/DE69132370T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/64—Fats; Fatty oils; Ester-type waxes; Higher fatty acids, i.e. having at least seven carbon atoms in an unbroken chain bound to a carboxyl group; Oxidised oils or fats
    • C12P7/6436—Fatty acid esters
    • C12P7/6445—Glycerides
    • C12P7/6472—Glycerides containing polyunsaturated fatty acid [PUFA] residues, i.e. having two or more double bonds in their backbone
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K20/00—Accessory food factors for animal feeding-stuffs
    • A23K20/10—Organic substances
    • A23K20/158—Fatty acids; Fats; Products containing oils or fats
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K50/00—Feeding-stuffs specially adapted for particular animals
    • A23K50/80—Feeding-stuffs specially adapted for particular animals for aquatic animals, e.g. fish, crustaceans or molluscs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
    • C07C57/02—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms with only carbon-to-carbon double bonds as unsaturation
    • C07C57/03—Monocarboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/12—Unicellular algae; Culture media therefor
DE69132370T 1990-03-21 1991-03-20 Methode zur herstellung von eicosapentansäuren Expired - Fee Related DE69132370T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US07/496,572 US5244921A (en) 1990-03-21 1990-03-21 Eicosapentaenoic acids and methods for their production
PCT/US1991/002052 WO1991014427A1 (en) 1990-03-21 1991-03-20 Eicosapentaenoic acids and methods for their production

Publications (2)

Publication Number Publication Date
DE69132370D1 true DE69132370D1 (de) 2000-09-21
DE69132370T2 DE69132370T2 (de) 2001-03-29

Family

ID=23973229

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69132370T Expired - Fee Related DE69132370T2 (de) 1990-03-21 1991-03-20 Methode zur herstellung von eicosapentansäuren

Country Status (7)

Country Link
US (2) US5244921A (de)
EP (1) EP0521104B1 (de)
JP (1) JPH05505726A (de)
AT (1) ATE195420T1 (de)
CA (1) CA2078664A1 (de)
DE (1) DE69132370T2 (de)
WO (1) WO1991014427A1 (de)

Families Citing this family (77)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060094089A1 (en) * 1988-09-07 2006-05-04 Martek Biosciences Corporation Process for the heterotrophic production of microbial products with high concentrations of omega-3 highly unsaturated fatty acids
US6451567B1 (en) 1988-09-07 2002-09-17 Omegatech, Inc. Fermentation process for producing long chain omega-3 fatty acids with euryhaline microorganisms
US5340742A (en) * 1988-09-07 1994-08-23 Omegatech Inc. Process for growing thraustochytrium and schizochytrium using non-chloride salts to produce a microfloral biomass having omega-3-highly unsaturated fatty acids
US5985348A (en) * 1995-06-07 1999-11-16 Omegatech, Inc. Milk products having high concentrations of omega-3 highly unsaturated fatty acids
ZA92452B (en) 1991-01-24 1992-10-28 Martek Corp Microbial oil mixtures and uses thereof
US6410281B1 (en) 1992-07-10 2002-06-25 Omegatech, Inc. Reducing corrosion in a fermentor by providing sodium with a non-chloride sodium salt
US6255505B1 (en) 1996-03-28 2001-07-03 Gist-Brocades, B.V. Microbial polyunsaturated fatty acid containing oil from pasteurised biomass
JP3096654B2 (ja) * 1997-04-01 2000-10-10 クロレラ工業株式会社 高度不飽和脂肪酸含有クロレラの製造方法
JP4623829B2 (ja) * 1998-08-18 2011-02-02 メタボリックス，インコーポレイテッド トランスジェニック微生物のポリヒドロキシアルカノエート産生
US6166231A (en) * 1998-12-15 2000-12-26 Martek Biosciences Corporation Two phase extraction of oil from biomass
GB9916537D0 (en) 1999-07-14 1999-09-15 Univ Hull Culture of microorganisms for the synthesis of a polyunsaturated fatty acid
ATE374531T1 (de) * 2000-01-28 2007-10-15 Martek Biosciences Corp Verstaerkte produktion von lipiden enthaltend mehrfachungesaettigte fettsaeuren durch hochdichte kulturen von eukariotischen mikroben in gaervorrichtungen
EP1780283A1 (de) 2000-04-21 2007-05-02 Martek Biosciences Corporation Trophische Umwandlung von obligat phototropischen Algen durch metabolische Manipulation
EP1276885B1 (de) * 2000-04-21 2007-09-12 Martek Biosciences Corporation Trophische umwandlung von obligat phototropischen algen durch metabolische manipulation
GB2377455A (en) * 2001-02-09 2003-01-15 Univ Hull Method of culturing crypthecodinium cohnii
FR2822701B1 (fr) * 2001-04-03 2005-03-18 Lvmh Rech Utilisation d'un extrait d'algue phaeodactylum comme agent cosmetique favorisant l'activite du proteasome des cellules de la peau et composition cosmetique le contenant
GB0113348D0 (en) * 2001-06-01 2001-07-25 Mars Uk Ltd Skin diet
EP1304029A1 (de) 2001-10-19 2003-04-23 Dsm N.V. Polyungesättigte Fettsäuren in Eier
CN101837135B (zh) 2002-06-19 2014-09-24 帝斯曼知识产权资产管理有限公司 用于微生物细胞和微生物油的巴氏消毒方法
CA2395622A1 (fr) * 2002-07-22 2004-01-22 Edwin Bourget Procede d'enrichissement en lipides et en acides gras omega-3 dans les cultures d'algues
GB0301701D0 (en) * 2003-01-24 2003-02-26 Ensay Ltd Psoriasis and Eicosapentaenoic acid
US7238482B2 (en) 2003-05-07 2007-07-03 E. I. Du Pont De Nemours And Company Production of polyunsaturated fatty acids in oleaginous yeasts
US20070015263A1 (en) * 2003-09-01 2007-01-18 Mogens Wumpelmann Method for increasing yield of biomass of and/or components of biomass from marine microorganisms
US20100021555A1 (en) * 2004-10-15 2010-01-28 Karl Geiringer Compositions containing high omega-3 and low saturated fatty acid levels
US7588931B2 (en) * 2004-11-04 2009-09-15 E. I. Du Pont De Nemours And Company High arachidonic acid producing strains of Yarrowia lipolytica
US7198937B2 (en) * 2004-11-04 2007-04-03 E. I. Du Pont De Nemours And Company Mortierella alpina diacylglycerol acyltransferase for alteration of polyunsaturated fatty acids and oil content in oleaginous organisms
US8685679B2 (en) * 2004-11-04 2014-04-01 E I Du Pont De Nemours And Company Acyltransferase regulation to increase the percent of polyunsaturated fatty acids in total lipids and oils of oleaginous organisms
CA2611324C (en) 2005-06-07 2017-02-14 Ocean Nutrition Canada Limited Eukaryotic microorganisms for producing lipids and antioxidants
GB0604647D0 (en) 2006-03-08 2006-04-19 Shchepinov Mikhail Stabilized food supplements and their derivatives
JP5242949B2 (ja) * 2006-05-31 2013-07-24 独立行政法人水産総合研究センター 藻類へのケイ酸成分供給方法
EP2043970B1 (de) * 2006-07-05 2018-04-18 Centre National De La Recherche Scientifique (C.N.R.S.) Co-katalysiertes eisen-kupfer-verfahren für kohlenstoff-kohlenstoff- oder kohlenstoff-heteroatom-bindung
EP2044208A4 (de) * 2006-07-05 2012-02-22 Photonz Corp Ltd Herstellung von ultrareinen epa- und polaren lipiden aus überwiegend heterotropher kultur
CN101981201A (zh) 2006-08-01 2011-02-23 加拿大海洋营养食品有限公司 产油微生物及改良这些微生物的方法
US20100028962A1 (en) * 2006-09-18 2010-02-04 Qiang Hu Algal Medium Chain Length Fatty Acids and Hydrocarbons
US8088614B2 (en) * 2006-11-13 2012-01-03 Aurora Algae, Inc. Methods and compositions for production and purification of biofuel from plants and microalgae
US8221743B2 (en) 2006-12-22 2012-07-17 Novozymes A/S Use of polypeptides against diseases caused by protozoans
WO2009046231A1 (en) 2007-10-03 2009-04-09 E. I. Du Pont De Nemours And Company Optimized strains of yarrowia lipolytica for high eicosapentaenoic acid production
US8343753B2 (en) * 2007-11-01 2013-01-01 Wake Forest University School Of Medicine Compositions, methods, and kits for polyunsaturated fatty acids from microalgae
US8207363B2 (en) 2009-03-19 2012-06-26 Martek Biosciences Corporation Thraustochytrids, fatty acid compositions, and methods of making and uses thereof
ES2482592T3 (es) * 2009-04-10 2014-08-04 Electric Power Development Co., Ltd. Microalga perteneciente al género Navicula, proceso para la producción de aceite mediante el cultivo de la microalga y aceite recogido a partir de la microalga
JP5636039B2 (ja) * 2009-04-14 2014-12-03 ソラザイム、インクＳｏｌａｚｙｍｅ Ｉｎｃ 新規微細藻類食物組成物
US8865452B2 (en) * 2009-06-15 2014-10-21 Aurora Algae, Inc. Systems and methods for extracting lipids from wet algal biomass
US9101942B2 (en) * 2009-06-16 2015-08-11 Aurora Algae, Inc. Clarification of suspensions
US8747930B2 (en) * 2009-06-29 2014-06-10 Aurora Algae, Inc. Siliceous particles
US8765983B2 (en) * 2009-10-30 2014-07-01 Aurora Algae, Inc. Systems and methods for extracting lipids from and dehydrating wet algal biomass
KR20150013667A (ko) 2010-01-19 2015-02-05 디에스엠 아이피 어셋츠 비.브이. 에이코사펜타엔산 생산 미생물, 지방산 조성물 및 이의 제조방법 및 용도
US20110256282A1 (en) * 2010-04-14 2011-10-20 Solazyme Roquette Nutritionals, LLC Lipid-Rich Microalgal Flour Food Compositions
CN103282474A (zh) 2010-04-22 2013-09-04 纳幕尔杜邦公司 从微生物生物质中获得包含多不饱和脂肪酸的组合物的方法
ES2733134T3 (es) 2010-06-09 2019-11-27 Fermentalg Composiciones que comprenden ácido eicosapentaenoico adecuado para una alta purificación
US9023625B2 (en) 2010-06-14 2015-05-05 Io-Mega Holding Corporation Methods for production of algae derived oils
CA2805891A1 (en) 2010-08-11 2012-02-16 Scott E. Nichols A sustainable aquaculture feeding strategy
US20120040076A1 (en) 2010-08-11 2012-02-16 E. I. Du Pont De Nemours And Company Aquaculture feed compositions
CA2805882A1 (en) 2010-08-11 2012-02-16 E. I. Dupont De Nemours And Company Improved aquaculture meat products
KR20130138760A (ko) 2010-08-26 2013-12-19 이 아이 듀폰 디 네모아 앤드 캄파니 고농도의 에이코사펜타엔산 생성을 위한 재조합 미생물 숙주 세포
NZ588781A (en) * 2010-10-22 2013-08-30 Photonz Corp Ltd Method of provision of silicate to culture media
US8926844B2 (en) 2011-03-29 2015-01-06 Aurora Algae, Inc. Systems and methods for processing algae cultivation fluid
US8569530B2 (en) 2011-04-01 2013-10-29 Aurora Algae, Inc. Conversion of saponifiable lipids into fatty esters
KR20140033378A (ko) 2011-05-06 2014-03-18 솔라짐, 인코포레이티드 자일로오스를 대사시키는 유전자 조작된 미생물
CN108771240A (zh) 2011-07-21 2018-11-09 帝斯曼知识产权资产管理有限公司 脂肪酸组合物
KR102271711B1 (ko) 2012-12-24 2021-07-01 퀄리타스 헬스 인코포레이티드 에이코사펜타엔산 (ｅｐａ) 제형
US10098371B2 (en) 2013-01-28 2018-10-16 Solazyme Roquette Nutritionals, LLC Microalgal flour
JP6300220B2 (ja) * 2013-03-04 2018-03-28 国立大学法人山口大学 微細藻類を用いた脂質の製造方法
PT2970926T (pt) 2013-03-13 2018-03-22 Dsm Nutritional Products Ag Modificação genética de microrganismos
US9266973B2 (en) 2013-03-15 2016-02-23 Aurora Algae, Inc. Systems and methods for utilizing and recovering chitosan to process biological material
EP2826384A1 (de) 2013-07-16 2015-01-21 Evonik Industries AG Verfahren zur Trocknung von Biomasse
US9879218B2 (en) 2013-08-01 2018-01-30 Fermentalg Methods for the production of diatom biomass
FR3009619B1 (fr) 2013-08-07 2017-12-29 Roquette Freres Compositions de biomasse de microalgues riches en proteines de qualite sensorielle optimisee
WO2016050559A1 (de) 2014-10-02 2016-04-07 Evonik Degussa Gmbh VERFAHREN ZUR HERSTELLUNG EINES PUFAs ENTHALTENDEN FUTTERMITTELS DURCH EXTRUSION EINER PUFAs ENTHALTENDEN BIOMASSE
WO2016050552A1 (de) 2014-10-02 2016-04-07 Evonik Degussa Gmbh Verfahren zur herstellung einer pufas enthaltenden biomasse mit hoher zellstabilität
ES2900848T3 (es) 2014-10-02 2022-03-18 Evonik Operations Gmbh Procedimiento para la producción de un pienso
US11464244B2 (en) 2014-10-02 2022-10-11 Evonik Operations Gmbh Feedstuff of high abrasion resistance and good stability in water, containing PUFAs
AR104042A1 (es) 2015-03-26 2017-06-21 Mara Renewables Corp Producción de alta densidad de biomasa y aceite utilizando glicerol en bruto
MX2018000502A (es) 2015-07-13 2018-09-07 Mara Renewables Corp Mejora del metabolismo de microalga de xilosa.
JP6625370B2 (ja) * 2015-08-24 2019-12-25 岡山県 藻類の培養密度を向上させるための組成物およびその利用
US10851395B2 (en) 2016-06-10 2020-12-01 MARA Renewables Corporation Method of making lipids with improved cold flow properties
RU2661116C1 (ru) * 2017-12-13 2018-07-11 Общество с ограниченной ответственностью "СОЛИКСАНТ" Штамм одноклеточной микроводоросли Eustigmatos magnus - продуцент эйкозапентаеновой кислоты
NO20201076A1 (en) 2020-10-01 2022-04-04 Finnfjord As Process for cultivation of diatoms

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2725677A (en) * 1952-01-16 1955-12-06 Carnegie Inst Of Washington Method of effectuating high density mass culture of algae or other microorganisms
US4670285A (en) * 1982-08-06 1987-06-02 The University Of Toronto Innovations Foundation Infant formula
JPS5946225A (ja) * 1982-09-09 1984-03-15 Kogyo Kaihatsu Kenkyusho 抗動脈硬化剤の製造方法
JPS6034156A (ja) * 1983-08-08 1985-02-21 Hayashibara Biochem Lab Inc エイコサペンタエン酸包接化合物及びこれを含有した飲食物
JPS60133094A (ja) * 1983-12-21 1985-07-16 日清製油株式会社 高純度エイコサペンタエン酸の製造法
JPS63185390A (ja) * 1987-01-27 1988-07-30 Suntory Ltd 藻類によるエイコサペンタエン酸の製造方法
WO1989000606A1 (en) * 1987-07-20 1989-01-26 Maricultura, Incorporated Microorganism production of omega-3 (n-3) lipids

Also Published As

Publication number Publication date
WO1991014427A1 (en) 1991-10-03
EP0521104A4 (en) 1993-03-24
CA2078664A1 (en) 1991-09-22
US5244921A (en) 1993-09-14
US5567732A (en) 1996-10-22
EP0521104A1 (de) 1993-01-07
EP0521104B1 (de) 2000-08-16
DE69132370T2 (de) 2001-03-29
ATE195420T1 (de) 2000-09-15
JPH05505726A (ja) 1993-08-26

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