DE69133122D1 - Saccharidzusammensetzungen, Verfahren und Apparate zu deren Synthese - Google Patents

Saccharidzusammensetzungen, Verfahren und Apparate zu deren Synthese

Info

Publication number
DE69133122D1
DE69133122D1 DE69133122T DE69133122T DE69133122D1 DE 69133122 D1 DE69133122 D1 DE 69133122D1 DE 69133122 T DE69133122 T DE 69133122T DE 69133122 T DE69133122 T DE 69133122T DE 69133122 D1 DE69133122 D1 DE 69133122D1
Authority
DE
Germany
Prior art keywords
saccharide
saccharide compositions
compositions
synthesis
methods
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69133122T
Other languages
English (en)
Inventor
Steve Roth
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Pennsylvania Penn
Original Assignee
University of Pennsylvania Penn
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of Pennsylvania Penn filed Critical University of Pennsylvania Penn
Priority claimed from PCT/US1991/002430 external-priority patent/WO1991016449A1/en
Application granted granted Critical
Publication of DE69133122D1 publication Critical patent/DE69133122D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N11/00—Carrier-bound or immobilised enzymes; Carrier-bound or immobilised microbial cells; Preparation thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1048—Glycosyltransferases (2.4)
    • C12N9/1051—Hexosyltransferases (2.4.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/18—Preparation of compounds containing saccharide radicals produced by the action of a glycosyl transferase, e.g. alpha-, beta- or gamma-cyclodextrins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/26—Preparation of nitrogen-containing carbohydrates
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/814—Enzyme separation or purification
    • Y10S435/815—Enzyme separation or purification by sorption
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/819—Fermentation vessels in series
DE69133122T 1990-04-16 1991-04-11 Saccharidzusammensetzungen, Verfahren und Apparate zu deren Synthese Expired - Lifetime DE69133122D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US50956090A 1990-04-16 1990-04-16
PCT/US1991/002430 WO1991016449A1 (en) 1990-04-16 1991-04-11 Saccharide compositions, methods and apparatus for their synthesis

Publications (1)

Publication Number Publication Date
DE69133122D1 true DE69133122D1 (de) 2002-11-07

Family

ID=24027151

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69133122T Expired - Lifetime DE69133122D1 (de) 1990-04-16 1991-04-11 Saccharidzusammensetzungen, Verfahren und Apparate zu deren Synthese

Country Status (12)

Country Link
US (1) US6569649B2 (de)
JP (2) JPH05500905A (de)
KR (1) KR920702721A (de)
AT (1) ATE225402T1 (de)
AU (1) AU642253B2 (de)
BG (1) BG61170B1 (de)
BR (1) BR9106345A (de)
CA (1) CA2062715A1 (de)
DE (1) DE69133122D1 (de)
HU (1) HU216881B (de)
OA (1) OA09678A (de)
ZA (1) ZA912840B (de)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6962809B1 (en) 2001-07-02 2005-11-08 Hitachi, Ltd. Sugar chain synthesizer
JP4006385B2 (ja) 2002-11-20 2007-11-14 株式会社日立ハイテクノロジーズ 糖鎖合成装置
WO2004099271A1 (ja) 2003-05-08 2004-11-18 Toyo Boseki Kabushiki Kaisha 糖鎖含有水溶性ポリマー化合物
JP4252922B2 (ja) 2004-03-31 2009-04-08 株式会社日立ハイテクノロジーズ 糖鎖合成装置
KR101137021B1 (ko) 2006-11-30 2012-04-19 한국생명공학연구원 퓨조박테리움 뉴클레텀 유래의 신규 글리코실트랜스퍼라제및 이를 이용한 올리고당 제조방법
KR100888513B1 (ko) * 2006-12-15 2009-03-12 주식회사 진켐 신규 ｎ―아세틸글루코사민―２―에피머라아제 및 이를이용한 ｃｍｐ―ｎ―아세틸뉴라민산의 제조방법
ES2709599T3 (es) * 2013-02-21 2019-04-16 Jennewein Biotechnologie Gmbh Oligosacáridos fucosilados sintéticos o recombinantes para uso en el tratamiento de infecciones

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US4184917A (en) 1974-04-01 1980-01-22 Sandoz Ltd. Process for producing a structurally modified interferon
US4150116A (en) 1978-02-21 1979-04-17 Forsyth Dental Infirmary For Children Immunization against dental caries with glucosyltransferase antigens
US4219571A (en) 1978-06-15 1980-08-26 Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo Process for producing a sweetener
JPS5539304A (en) * 1978-09-13 1980-03-19 Shoei Netsukougiyou Kk Drying furnace for printed matter
US4261976A (en) 1978-10-03 1981-04-14 The Massachusetts General Hospital Method and glycoprotein composition for inhibition of growth of transformed cells and tumors
ATE6163T1 (de) 1979-11-07 1984-02-15 Tate & Lyle Public Limited Company Herstellung von isomaltulose.
JPS5836959B2 (ja) 1980-08-21 1983-08-12 三井製糖株式会社 固定化α−グルコシルトランスフエラ−ゼによるパラチノ−スの製造法
US4818816A (en) 1981-04-28 1989-04-04 Choay, S.A. Process for the organic synthesis of oligosaccharides and derivatives thereof
FR2535324A1 (fr) 1982-10-27 1984-05-04 Choay Sa Station perfectionnee pour l'epuration d'eaux usees
JPS58870A (ja) 1981-06-20 1983-01-06 Hayashibara Biochem Lab Inc 飲食物及びその製造方法
FR2509313A1 (fr) 1981-07-08 1983-01-14 Choay Sa Derives de 3-fucosyl-n-acetyl lactosamine, leur preparation et leurs applications biologiques
JPS58149697A (ja) 1982-02-27 1983-09-06 Dainippon Ink & Chem Inc β−１，３グリコシルステビオシドの製造方法
JPS58170493A (ja) 1982-04-01 1983-10-07 Yamasa Shoyu Co Ltd ３′−デオキシグアノシンの製造法
US4569909A (en) 1982-06-03 1986-02-11 Seitetsu Kagaku Co., Ltd. Process for preparing uridine diphosphate-N-acetylgalactosamine
CA1236090A (en) * 1982-07-30 1988-05-03 Harry G. Rittenhouse Determination of carbohydrate acceptors
US4770994A (en) * 1982-07-30 1988-09-13 Abbott Laboratories Determination of carbohydrate acceptors
JPS59118053A (ja) 1982-12-24 1984-07-07 Hayashibara Biochem Lab Inc 飲食物とその製造方法
US4678747A (en) 1983-02-18 1987-07-07 Sloan-Kettering Institute For Cancer Research Monoclonal antibodies for detection of an H (O) blood group antigen
US4557927A (en) 1983-03-10 1985-12-10 Kabushiki Kaisha Hoyashibara Food products and process for producing same
JPS59187787A (ja) 1983-04-11 1984-10-24 Meito Sangyo Kk 酵素法スフインゴリン脂質誘導体の製法
JPS59187792A (ja) 1983-04-11 1984-10-24 Meito Sangyo Kk 酵素法リン脂質糖類誘導体の製法
US4683297A (en) 1983-06-07 1987-07-28 Daicel Chemical Industries Ltd. Process for the preparation of glycosides
GB8316790D0 (en) 1983-06-21 1983-07-27 Tate & Lyle Plc Chemical process
US4757012A (en) 1983-06-28 1988-07-12 Genentech, Inc. Ascorbic acid intermediates and process enzymes
SE8304006D0 (sv) 1983-07-15 1983-07-15 Karlsson Karl Anders Forening och komposition for terapeutisk eller diagnostisk anvendning samt forfarande for terapeutisk behandling
JPS60114193A (ja) 1983-11-22 1985-06-20 Toyo Jozo Co Ltd 新規なマルトースデヒドロゲナーゼおよびその製法それを用いる分析法
HU194939B (en) 1983-12-22 1988-03-28 Chinoin Gyogyszer Es Vegyeszet Process for producing alpha- beta- and gamma cyclodextrine of high yield capacity
DE3446380C1 (de) 1984-12-19 1986-05-22 Pfeifer & Langen, 5000 Köln Suessungsmittel,Verfahren zur Herstellung und Verwendung desselben
US4868104A (en) 1985-09-06 1989-09-19 Syntex (U.S.A.) Inc. Homogeneous assay for specific polynucleotides
SE451849B (sv) 1985-12-11 1987-11-02 Svenska Sockerfabriks Ab Sett att syntetisera glykosidiska bindningar samt anvendning av pa detta sett erhallna produkter
US4912093A (en) 1986-10-01 1990-03-27 Marion Laboratories, Inc. Use of synthetic sulfated saccharides to enhance wound healing
DK617386A (da) 1985-12-26 1987-06-27 Takeda Chemical Industries Ltd Fremgangsmaade til fremstilling af 2-keto-d-glucarsyre
US4851517A (en) 1986-02-26 1989-07-25 Monsanto Company Tissue plasminogen activator oligosaccharide from normal human colon cells
US4925796A (en) 1986-03-07 1990-05-15 Massachusetts Institute Of Technology Method for enhancing glycoprotein stability
DE3626213A1 (de) 1986-08-02 1988-02-04 Hoechst Ag Enzymatische synthese von cyclodextrinen mit (alpha)-glucosylfluorid als substrat fuer cyclodextrin-(alpha)(1->4)glucosyltransferase
US4865976A (en) 1986-09-10 1989-09-12 Uop Method of cyclodextrin manufacture using an immobilized cyclodextrin glycosyltransferase
JPS63185352A (ja) * 1986-09-30 1988-07-30 Taiho Akira 腫瘍の予防効果を有する食品
US4835264A (en) 1986-12-12 1989-05-30 National Jewish Center Synthesis of 3,6-Di-O-methyl-D-glucose and compounds formed thereby
DE3644401A1 (de) 1986-12-24 1988-07-07 Boehringer Mannheim Gmbh Neue hydrolase-substrate
NL8701616A (nl) 1987-07-09 1989-02-01 Stamicarbon Fructosyltransferase en bereiding van fructose-oligomeren daarmee.
US4855128A (en) 1988-01-14 1989-08-08 Warner-Lambert Company Saccharide inhibition of dental plaque
SE466403B (sv) 1988-03-24 1992-02-10 Kurt G I Nilsson Saett att syntetisera oligosackarider
JPH0698012B2 (ja) 1988-05-13 1994-12-07 農林水産省食品総合研究所長 複分岐グルコシルーサイクロデキストリンの製法
EP0356048A3 (de) * 1988-08-05 1990-11-14 Uop Cyclodextrin-Glycosyl-Transferase
US5874261A (en) * 1988-09-02 1999-02-23 The Trustees Of The University Of Pennsylvania Method for the purification of glycosyltransferases
DK626488D0 (da) 1988-11-10 1988-11-10 Torben Falck Oerntoft Fremgangsmaade til udtagning af en sekretproeve via en legemsaabning og til praeparation af proeven med henblik paa kvantitativ bestemmelse af molekylaere strukturer og enzymaktivitet i proeven samt proeveudtagningsindretning til brug derved
US5032519A (en) * 1989-10-24 1991-07-16 The Regents Of The Univ. Of California Method for producing secretable glycosyltransferases and other Golgi processing enzymes

Also Published As

Publication number Publication date
HU9203266D0 (en) 1993-03-29
BG61170B1 (bg) 1997-01-31
AU7685291A (en) 1991-11-11
ATE225402T1 (de) 2002-10-15
ZA912840B (en) 1992-01-29
JP2002218992A (ja) 2002-08-06
HUT63202A (en) 1993-07-28
BR9106345A (pt) 1993-04-20
JPH05500905A (ja) 1993-02-25
US20020045222A1 (en) 2002-04-18
US6569649B2 (en) 2003-05-27
CA2062715A1 (en) 1991-10-17
KR920702721A (ko) 1992-10-06
HU216881B (hu) 1999-09-28
AU642253B2 (en) 1993-10-14
OA09678A (en) 1993-05-15

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Legal Events

Date Code Title Description
8332 No legal effect for de