DE69205971T2 - Orale dosierungsform mit verzögerter wirkstoffabgabe für die behandlung von intestinalen krankheiten. - Google Patents

Orale dosierungsform mit verzögerter wirkstoffabgabe für die behandlung von intestinalen krankheiten.

Info

Publication number
DE69205971T2
DE69205971T2 DE69205971T DE69205971T DE69205971T2 DE 69205971 T2 DE69205971 T2 DE 69205971T2 DE 69205971 T DE69205971 T DE 69205971T DE 69205971 T DE69205971 T DE 69205971T DE 69205971 T2 DE69205971 T2 DE 69205971T2
Authority
DE
Germany
Prior art keywords
pct
granules
dosage form
drug
coated
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69205971T
Other languages
English (en)
Other versions
DE69205971D1 (de
Inventor
John Rhodes
Brian Kenneth Evans
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Tillotts Pharma AG
Original Assignee
Tillotts Pharma AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Tillotts Pharma AG filed Critical Tillotts Pharma AG
Application granted granted Critical
Publication of DE69205971D1 publication Critical patent/DE69205971D1/de
Publication of DE69205971T2 publication Critical patent/DE69205971T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4891—Coated capsules; Multilayered drug free capsule shells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/65—Tetracyclines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/24—Heavy metals; Compounds thereof
    • A61K33/245—Bismuth; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/52—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an inorganic compound, e.g. an inorganic ion that is complexed with the active ingredient
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/58—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. poly[meth]acrylate, polyacrylamide, polystyrene, polyvinylpyrrolidone, polyvinylalcohol or polystyrene sulfonic acid resin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5026—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
DE69205971T 1991-02-22 1992-02-21 Orale dosierungsform mit verzögerter wirkstoffabgabe für die behandlung von intestinalen krankheiten. Expired - Lifetime DE69205971T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB9103795A GB2253346A (en) 1991-02-22 1991-02-22 Delayed release oral dosage forms for treatment of intestinal disorders
PCT/GB1992/000318 WO1992014452A1 (en) 1991-02-22 1992-02-21 Delayed release oral dosage forms for treatment of intestinal disorders

Publications (2)

Publication Number Publication Date
DE69205971D1 DE69205971D1 (de) 1995-12-14
DE69205971T2 true DE69205971T2 (de) 1996-04-11

Family

ID=10690451

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69205971T Expired - Lifetime DE69205971T2 (de) 1991-02-22 1992-02-21 Orale dosierungsform mit verzögerter wirkstoffabgabe für die behandlung von intestinalen krankheiten.

Country Status (23)

Country Link
US (1) US5401512A (de)
EP (1) EP0572486B1 (de)
JP (1) JP2958116B2 (de)
KR (1) KR100220322B1 (de)
AT (1) ATE129893T1 (de)
AU (1) AU652032B2 (de)
CA (1) CA2104686C (de)
CZ (1) CZ281792B6 (de)
DE (1) DE69205971T2 (de)
DK (1) DK0572486T3 (de)
ES (1) ES2079183T3 (de)
FI (1) FI105255B (de)
GB (1) GB2253346A (de)
GE (1) GEP19971086B (de)
GR (1) GR3018455T3 (de)
HU (1) HU219449B (de)
IE (1) IE74225B1 (de)
IL (1) IL101036A (de)
IN (1) IN179089B (de)
NO (1) NO307405B1 (de)
NZ (1) NZ241687A (de)
WO (1) WO1992014452A1 (de)
YU (1) YU17892A (de)

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Also Published As

Publication number Publication date
EP0572486B1 (de) 1995-11-08
FI933680A0 (fi) 1993-08-20
NO932979D0 (no) 1993-08-20
ATE129893T1 (de) 1995-11-15
CZ281792B6 (cs) 1997-01-15
KR930702963A (ko) 1993-11-29
EP0572486A1 (de) 1993-12-08
FI105255B (fi) 2000-07-14
NO307405B1 (no) 2000-04-03
NZ241687A (en) 1993-09-27
CZ162693A3 (en) 1994-10-19
AU1279592A (en) 1992-09-15
FI933680A (fi) 1993-08-20
HU219449B (hu) 2001-04-28
JPH06505246A (ja) 1994-06-16
HU9302379D0 (en) 1993-11-29
KR100220322B1 (ko) 1999-09-15
GEP19971086B (en) 1997-12-02
YU17892A (sh) 1994-12-28
GB2253346A (en) 1992-09-09
CA2104686C (en) 2000-05-02
AU652032B2 (en) 1994-08-11
DE69205971D1 (de) 1995-12-14
DK0572486T3 (da) 1995-12-11
IN179089B (de) 1997-08-23
JP2958116B2 (ja) 1999-10-06
ES2079183T3 (es) 1996-01-01
US5401512A (en) 1995-03-28
CA2104686A1 (en) 1992-08-23
GB9103795D0 (en) 1991-04-10
IL101036A0 (en) 1992-11-15
IE74225B1 (en) 1997-07-16
IL101036A (en) 1996-05-14
HUT65914A (en) 1994-07-28
GR3018455T3 (en) 1996-03-31
IE920548A1 (en) 1992-08-26
WO1992014452A1 (en) 1992-09-03
NO932979L (no) 1993-08-20

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