DE69218938D1 - Mikrokugeln für therapeutische gefässverschlüsse und diese enthaltende injektionslösungen - Google Patents

Mikrokugeln für therapeutische gefässverschlüsse und diese enthaltende injektionslösungen

Info

Publication number
DE69218938D1
DE69218938D1 DE69218938T DE69218938T DE69218938D1 DE 69218938 D1 DE69218938 D1 DE 69218938D1 DE 69218938 T DE69218938 T DE 69218938T DE 69218938 T DE69218938 T DE 69218938T DE 69218938 D1 DE69218938 D1 DE 69218938D1
Authority
DE
Germany
Prior art keywords
microballs
caps
solutions containing
injection solutions
therapeutic vascular
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69218938T
Other languages
English (en)
Other versions
DE69218938T2 (de
Inventor
Egisto Boschetti
Michel Brouard
Ludovic Drouet
Pierre Girot
Alexandre Laurent
Michel Wasser
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Assistance Publique Hopitaux de Paris APHP
BioSepra SA
Original Assignee
Assistance Publique Hopitaux de Paris APHP
BioSepra SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Assistance Publique Hopitaux de Paris APHP, BioSepra SA filed Critical Assistance Publique Hopitaux de Paris APHP
Application granted granted Critical
Publication of DE69218938D1 publication Critical patent/DE69218938D1/de
Publication of DE69218938T2 publication Critical patent/DE69218938T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
    • A61L24/04—Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials
    • A61L24/06—Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials obtained by reactions only involving carbon-to-carbon unsaturated bonds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/167—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction with an outer layer or coating comprising drug; with chemically bound drugs or non-active substances on their surface
    • A61K9/1676—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction with an outer layer or coating comprising drug; with chemically bound drugs or non-active substances on their surface having a drug-free core with discrete complete coating layer containing drug
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2400/00—Materials characterised by their function or physical properties
    • A61L2400/06—Flowable or injectable implant compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2430/00—Materials or treatment for tissue regeneration
    • A61L2430/36—Materials or treatment for tissue regeneration for embolization or occlusion, e.g. vaso-occlusive compositions or devices
DE69218938T 1991-05-29 1992-05-20 Mikrokugeln für therapeutische gefässverschlüsse und diese enthaltende injektionslösungen Expired - Lifetime DE69218938T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR9106441A FR2676927B1 (fr) 1991-05-29 1991-05-29 Microspheres utilisables pour les occlusions vasculaires therapeutiques et solutions injectables les contenant.
PCT/US1992/004265 WO1992021327A1 (en) 1991-05-29 1992-05-20 Microspheres useful for therapeutic vascular occlusions and injectable solutions containing the same

Publications (2)

Publication Number Publication Date
DE69218938D1 true DE69218938D1 (de) 1997-05-15
DE69218938T2 DE69218938T2 (de) 1997-07-31

Family

ID=9413226

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69218938T Expired - Lifetime DE69218938T2 (de) 1991-05-29 1992-05-20 Mikrokugeln für therapeutische gefässverschlüsse und diese enthaltende injektionslösungen

Country Status (11)

Country Link
US (2) US5635215A (de)
EP (1) EP0588875B1 (de)
JP (1) JP3509858B2 (de)
AT (1) ATE151284T1 (de)
AU (1) AU661319B2 (de)
CA (1) CA2110290C (de)
DE (1) DE69218938T2 (de)
DK (1) DK0588875T3 (de)
ES (1) ES2099827T3 (de)
FR (1) FR2676927B1 (de)
WO (1) WO1992021327A1 (de)

Families Citing this family (107)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4341478C2 (de) * 1993-12-02 1998-10-08 Max Delbrueck Centrum Mittel zur Antitumortherapie
US6197324B1 (en) 1997-12-18 2001-03-06 C. R. Bard, Inc. System and methods for local delivery of an agent
US6251418B1 (en) 1997-12-18 2001-06-26 C.R. Bard, Inc. Systems and methods for local delivery of an agent
EP1522317A1 (de) * 1998-03-06 2005-04-13 Biosphere Medical, Inc. Implantierbare Partikel zur Erhöhung des Gewebevolumens und zur Behandlung von Gastroösophagalreflux, Inkontinenz und Hautfalten
CA2322954C (en) * 1998-03-06 2011-06-07 Biosepra Inc. Implantable particles for tissue bulking and the treatment of gastroesophageal reflux disease, urinary incontinence, and skin wrinkles
US6660301B1 (en) 1998-03-06 2003-12-09 Biosphere Medical, Inc. Injectable microspheres for dermal augmentation and tissue bulking
FR2784580B1 (fr) * 1998-10-16 2004-06-25 Biosepra Inc Microspheres de polyvinyl-alcool et procedes de fabrication de celles-ci
EP2305324B1 (de) * 1999-03-25 2014-09-17 Metabolix, Inc. Medizinische Geräte und Anwendungen aus Polyhydroxyalkanoat-Polymeren
US20050049178A1 (en) * 1999-07-06 2005-03-03 Oberschwabenklinik Gmbh Agent for the occlusion of blood vessels
DE29911689U1 (de) * 1999-07-06 2000-04-06 Sterk Peter Mittel für den Gefässverschluß von organischem Gewebe
US6855160B1 (en) 1999-08-04 2005-02-15 C. R. Bard, Inc. Implant and agent delivery device
DE60115212T2 (de) 2000-03-13 2006-07-27 Biocure, Inc. Biomedizinische artikel aus hydrogel
DE60130544T2 (de) 2000-03-13 2008-06-26 Biocure, Inc. Embolische zusammensetzungen
WO2001070290A2 (en) * 2000-03-20 2001-09-27 Biosphere Medical, Inc. Injectable microspheres for tissue construction
EP1656957B1 (de) 2000-03-20 2015-06-03 Biosphere Medical, Inc. Injizierbare Mikrosphären zur Gewebekonstruktion
US6436424B1 (en) 2000-03-20 2002-08-20 Biosphere Medical, Inc. Injectable and swellable microspheres for dermal augmentation
US7338657B2 (en) * 2001-03-15 2008-03-04 Biosphere Medical, Inc. Injectable microspheres for tissue construction
WO2001070289A2 (en) * 2000-03-20 2001-09-27 Biosphere Medical, Inc. Injectable and swellable microspheres for tissue bulking
US20030212022A1 (en) * 2001-03-23 2003-11-13 Jean-Marie Vogel Compositions and methods for gene therapy
AU2001245987A1 (en) * 2000-03-24 2001-10-08 Biosphere Medical, Inc. Compositions and methods for gene therapy
DE60130743T2 (de) 2000-03-24 2008-07-17 Biosphere Medical, Inc., Rockland Mikrokugeln zur aktiven embolisierung
US7232421B1 (en) 2000-05-12 2007-06-19 C. R. Bard, Inc. Agent delivery systems
US6355275B1 (en) 2000-06-23 2002-03-12 Carbon Medical Technologies, Inc. Embolization using carbon coated microparticles
US6394965B1 (en) 2000-08-15 2002-05-28 Carbon Medical Technologies, Inc. Tissue marking using biocompatible microparticles
FR2816847B1 (fr) * 2000-11-22 2006-07-14 Assist Publ Hopitaux De Paris Biomateriaux polymeriques poreux, procede de preparation et utilisations
US9080146B2 (en) 2001-01-11 2015-07-14 Celonova Biosciences, Inc. Substrates containing polyphosphazene as matrices and substrates containing polyphosphazene with a micro-structured surface
WO2002100444A1 (en) * 2001-06-08 2002-12-19 Biosphere Medical Inc. Colloidal metal labelled microparticles, their production and use
JP2005511502A (ja) 2001-09-12 2005-04-28 ヴィレックス リサーチ インコーポレイテッド 固定化した血小板結合剤を有する血管閉塞固相剤
US7094369B2 (en) * 2002-03-29 2006-08-22 Scimed Life Systems, Inc. Processes for manufacturing polymeric microspheres
US7462366B2 (en) 2002-03-29 2008-12-09 Boston Scientific Scimed, Inc. Drug delivery particle
US7276254B2 (en) * 2002-05-07 2007-10-02 Xerox Corporation Emulsion/aggregation polymeric microspheres for biomedical applications and methods of making same
US7838699B2 (en) * 2002-05-08 2010-11-23 Biosphere Medical Embolization using degradable crosslinked hydrogels
US7670623B2 (en) * 2002-05-31 2010-03-02 Materials Modification, Inc. Hemostatic composition
WO2003105917A2 (en) 2002-06-12 2003-12-24 Scimed Life Systems, Inc. Bulking agents
US7842377B2 (en) 2003-08-08 2010-11-30 Boston Scientific Scimed, Inc. Porous polymeric particle comprising polyvinyl alcohol and having interior to surface porosity-gradient
US8012454B2 (en) 2002-08-30 2011-09-06 Boston Scientific Scimed, Inc. Embolization
US7112620B2 (en) * 2002-10-18 2006-09-26 Albright Robert L Hemocompatible polymer systems & related methods
US20040168245A1 (en) * 2002-10-18 2004-09-02 Goodwin Edward L. Washable, protective hip pad construction
US7883490B2 (en) 2002-10-23 2011-02-08 Boston Scientific Scimed, Inc. Mixing and delivery of therapeutic compositions
JP4686970B2 (ja) * 2002-10-29 2011-05-25 東レ株式会社 血管塞栓材料
WO2004039425A1 (ja) * 2002-10-29 2004-05-13 Toray Industries, Inc. 血管塞栓材料
AU2003285905A1 (en) * 2002-11-04 2004-06-07 Biosphere Medical, Inc. Radioisotope-associated polymeric hydrogel microspheres and methods for producing and using the same
US7560160B2 (en) * 2002-11-25 2009-07-14 Materials Modification, Inc. Multifunctional particulate material, fluid, and composition
US7007972B1 (en) 2003-03-10 2006-03-07 Materials Modification, Inc. Method and airbag inflation apparatus employing magnetic fluid
JP2004313759A (ja) * 2003-03-31 2004-11-11 Toray Ind Inc 血管塞栓材料
DK1638615T3 (en) 2003-05-08 2015-01-12 Tepha Inc MEDICAL POLYHYDROXYALKANOATE TEXTILES AND FIBERS
US6982501B1 (en) 2003-05-19 2006-01-03 Materials Modification, Inc. Magnetic fluid power generator device and method for generating power
JP2007528853A (ja) * 2003-07-08 2007-10-18 テファ， インコーポレイテッド 徐放性薬物送達のためのポリ−４−ヒドロキシブチレートマトリックス
US7200956B1 (en) 2003-07-23 2007-04-10 Materials Modification, Inc. Magnetic fluid cushioning device for a footwear or shoe
US20060287659A1 (en) * 2003-08-22 2006-12-21 Tepha, Inc. Polyhydroxyalkanoate nerve regeneration devices
US7976823B2 (en) 2003-08-29 2011-07-12 Boston Scientific Scimed, Inc. Ferromagnetic particles and methods
US7448389B1 (en) 2003-10-10 2008-11-11 Materials Modification, Inc. Method and kit for inducing hypoxia in tumors through the use of a magnetic fluid
US7736671B2 (en) 2004-03-02 2010-06-15 Boston Scientific Scimed, Inc. Embolization
US8173176B2 (en) 2004-03-30 2012-05-08 Boston Scientific Scimed, Inc. Embolization
US8080577B2 (en) * 2004-05-06 2011-12-20 Bioresponse, L.L.C. Diindolylmethane formulations for the treatment of leiomyomas
US7311861B2 (en) 2004-06-01 2007-12-25 Boston Scientific Scimed, Inc. Embolization
EP2221069B1 (de) * 2004-08-03 2012-05-09 Tepha, Inc. Polyhydroxyalkanoate Nähte die sich nicht aufrollen
JP5079510B2 (ja) * 2004-09-24 2012-11-21 バイオスフィア メディカル， インコーポレイテッド 放射性同位体を結合し得、任意選択的に金属微粒子を含むミクロスフェア、およびそれらの使用方法
US20060073208A1 (en) 2004-10-01 2006-04-06 Allergan, Inc. Cosmetic neurotoxin compositions and methods
US9114162B2 (en) 2004-10-25 2015-08-25 Celonova Biosciences, Inc. Loadable polymeric particles for enhanced imaging in clinical applications and methods of preparing and using the same
US20210299056A9 (en) 2004-10-25 2021-09-30 Varian Medical Systems, Inc. Color-Coded Polymeric Particles of Predetermined Size for Therapeutic and/or Diagnostic Applications and Related Methods
US9107850B2 (en) 2004-10-25 2015-08-18 Celonova Biosciences, Inc. Color-coded and sized loadable polymeric particles for therapeutic and/or diagnostic applications and methods of preparing and using the same
BRPI0518383A2 (pt) 2004-10-25 2008-11-18 Polyzenix Gmbh partÍculas polimÉricas carregÁveis para aplicaÇÕes terepÊuticas e/ou diagnàstico e mÉtodos para preparar e usar as mesmas
US8425550B2 (en) 2004-12-01 2013-04-23 Boston Scientific Scimed, Inc. Embolic coils
WO2006083458A2 (en) 2004-12-30 2006-08-10 Bioresponse Llc Use of diindolylmethane-related indoles for the treatment and prevention of respiratory syncytial virus associates conditions
WO2006078841A1 (en) * 2005-01-21 2006-07-27 President And Fellows Of Harvard College Systems and methods for forming fluidic droplets encapsulated in particles such as colloidal particles
ES2362221T3 (es) * 2005-01-28 2011-06-29 Tepha, Inc. Embolización con partículas poli-4-hidroxibutirato.
US7727555B2 (en) 2005-03-02 2010-06-01 Boston Scientific Scimed, Inc. Particles
US7858183B2 (en) 2005-03-02 2010-12-28 Boston Scientific Scimed, Inc. Particles
US7963287B2 (en) 2005-04-28 2011-06-21 Boston Scientific Scimed, Inc. Tissue-treatment methods
CN104815331A (zh) 2005-05-09 2015-08-05 生物领域医疗公司 使用微球和非离子型造影剂的组合物和方法
US9463426B2 (en) 2005-06-24 2016-10-11 Boston Scientific Scimed, Inc. Methods and systems for coating particles
US8007509B2 (en) 2005-10-12 2011-08-30 Boston Scientific Scimed, Inc. Coil assemblies, components and methods
US8152839B2 (en) 2005-12-19 2012-04-10 Boston Scientific Scimed, Inc. Embolic coils
US8101197B2 (en) 2005-12-19 2012-01-24 Stryker Corporation Forming coils
US7947368B2 (en) 2005-12-21 2011-05-24 Boston Scientific Scimed, Inc. Block copolymer particles
WO2007090127A2 (en) 2006-01-30 2007-08-09 Surgica Corporation Compressible intravascular embolization particles and related methods and delivery systems
WO2007090130A2 (en) * 2006-01-30 2007-08-09 Surgica Corporation Porous intravascular embolization particles and related methods
CN101489563A (zh) * 2006-07-06 2009-07-22 拜耳先灵医药股份有限公司 用于避孕和预防先天性畸形风险的药物制剂
WO2008057253A2 (en) * 2006-10-27 2008-05-15 Bioresponse, L.L.C. Anti-parasitic methods and compositions utilizing diindolylmethane-related indoles
US8414927B2 (en) 2006-11-03 2013-04-09 Boston Scientific Scimed, Inc. Cross-linked polymer particles
US7943683B2 (en) * 2006-12-01 2011-05-17 Tepha, Inc. Medical devices containing oriented films of poly-4-hydroxybutyrate and copolymers
WO2008134580A2 (en) * 2007-04-27 2008-11-06 Amylin Pharmaceuticals, Inc. Drug delivery device
US8038721B2 (en) * 2007-12-17 2011-10-18 Anna Love Soft tissue filler
US20110212179A1 (en) * 2008-10-30 2011-09-01 David Liu Micro-spherical porous biocompatible scaffolds and methods and apparatus for fabricating same
WO2010062734A1 (en) * 2008-11-03 2010-06-03 University Of Maryland, Baltimore Blood coagulation inducing polymer hydrogel
ES2445164T3 (es) * 2009-10-06 2014-02-28 Regents Of The University Of Minnesota Microesferas de embolización bioreabsorbibles
EP2351779B1 (de) * 2010-01-27 2019-04-24 Biosphere Medical, Inc. Mikrokügelchen und Verfahren zur Herstellung der Mikrokügelchen
WO2012133608A1 (ja) * 2011-03-30 2012-10-04 東レ株式会社 生分解性粒子、血管塞栓材料及び生分解性粒子の製造方法
CA2866896C (en) * 2012-05-24 2021-01-26 Biosphere Medical, Inc. Biomaterials suitable for use as drug eluting, magnetic resonance imaging detectable implants for vascular occlusion
US8936795B2 (en) 2012-12-19 2015-01-20 Regents Of The University Of Minnesota Liquid embolic material including carboxymethyl chitosan crosslinked with carboxymethyl cellulose
JP6373961B2 (ja) 2013-03-13 2018-08-15 バイオスフィア メディカル，インコーポレイテッド ラジオアイソトープ結合微粒子の組成物及び結合方法
WO2015042170A1 (en) 2013-09-17 2015-03-26 Wayne State University Compositions and uses of combinations of dim-related indoles and selected anti-androgen compounds
CN110279885B (zh) 2013-09-19 2022-07-26 泰尔茂株式会社 聚合物颗粒
KR102340388B1 (ko) 2013-09-19 2021-12-17 마이크로벤션, 인코포레이티드 중합체 필름
US9688788B2 (en) 2013-11-08 2017-06-27 Terumo Corporation Polymer particles
US10500303B2 (en) 2014-08-15 2019-12-10 Tepha, Inc. Self-retaining sutures of poly-4-hydroxybutyrate and copolymers thereof
EP3230500A1 (de) 2014-12-11 2017-10-18 Tepha, Inc. Verfahren zur ausrichtung von multifilamentgarn und monofilamenten aus poly-4-hydroxybutyrat und copolymere davon
US10626521B2 (en) 2014-12-11 2020-04-21 Tepha, Inc. Methods of manufacturing mesh sutures from poly-4-hydroxybutyrate and copolymers thereof
ES2956801T3 (es) 2015-01-12 2023-12-28 Biosphere Medical Inc Monómeros, polímeros, microesferas radiopacos y métodos relacionados con los mismos
US9907880B2 (en) 2015-03-26 2018-03-06 Microvention, Inc. Particles
US10071181B1 (en) 2015-04-17 2018-09-11 Teleflex Innovations S.À.R.L. Resorbable embolization spheres
US20190070332A1 (en) 2016-03-14 2019-03-07 Biocompatibles Uk Limited Oily compositions
US10182979B2 (en) 2016-03-22 2019-01-22 Regents Of The University Of Minnesota Biodegradable microspheres
EP3518994B1 (de) 2016-09-28 2024-02-07 Terumo Corporation Polymerpartikel
KR20220079600A (ko) * 2019-10-07 2022-06-13 게르브 비분해성 방사선 불투과성 색전술 미소구체
KR20220081358A (ko) * 2019-10-07 2022-06-15 게르브 비분해성 색전술 미소구체

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3797485A (en) * 1971-03-26 1974-03-19 Alza Corp Novel drug delivery device for administering drug into blood circulation in blood vessel
US4622362A (en) * 1981-03-30 1986-11-11 California Institute Of Technology Polyacrolein microspheres
US4413070A (en) * 1981-03-30 1983-11-01 California Institute Of Technology Polyacrolein microspheres
DE3360633D1 (en) * 1982-02-12 1985-10-03 Unitika Ltd Anti-cancer device
JPS61293911A (ja) * 1985-06-24 1986-12-24 Teisan Seiyaku Kk 徐放化製剤
JPS62169723A (ja) * 1986-01-22 1987-07-25 Teisan Seiyaku Kk 徐放化製剤

Also Published As

Publication number Publication date
EP0588875A4 (de) 1994-08-03
EP0588875A1 (de) 1994-03-30
WO1992021327A1 (en) 1992-12-10
US5648100A (en) 1997-07-15
AU661319B2 (en) 1995-07-20
JP3509858B2 (ja) 2004-03-22
US5635215A (en) 1997-06-03
DE69218938T2 (de) 1997-07-31
ATE151284T1 (de) 1997-04-15
FR2676927B1 (fr) 1995-06-23
AU2016892A (en) 1993-01-08
JPH06508139A (ja) 1994-09-14
EP0588875B1 (de) 1997-04-09
DK0588875T3 (da) 1997-04-28
CA2110290A1 (en) 1992-12-10
FR2676927A1 (fr) 1992-12-04
ES2099827T3 (es) 1997-06-01
CA2110290C (en) 2002-02-05

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