DE69223980T2 - Bindungstest unter benutzung eines markierten reagens - Google Patents

Bindungstest unter benutzung eines markierten reagens

Info

Publication number
DE69223980T2
DE69223980T2 DE69223980T DE69223980T DE69223980T2 DE 69223980 T2 DE69223980 T2 DE 69223980T2 DE 69223980 T DE69223980 T DE 69223980T DE 69223980 T DE69223980 T DE 69223980T DE 69223980 T2 DE69223980 T2 DE 69223980T2
Authority
DE
Germany
Prior art keywords
analyte
binding
binding agent
pct
capture
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69223980T
Other languages
English (en)
Other versions
DE69223980D1 (de
Inventor
Roger Ekins
Frederick Chu
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Multilyte Ltd
Original Assignee
Multilyte Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB919121873A external-priority patent/GB9121873D0/en
Application filed by Multilyte Ltd filed Critical Multilyte Ltd
Application granted granted Critical
Publication of DE69223980D1 publication Critical patent/DE69223980D1/de
Publication of DE69223980T2 publication Critical patent/DE69223980T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6816—Hybridisation assays characterised by the detection means
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G01N33/585—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with a particulate label, e.g. coloured latex

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Urology & Nephrology (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Cell Biology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Sampling And Sample Adjustment (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
DE69223980T 1991-10-15 1992-10-15 Bindungstest unter benutzung eines markierten reagens Expired - Lifetime DE69223980T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB919121873A GB9121873D0 (en) 1991-10-15 1991-10-15 Improved non-competitive sandwich immunoassay system
GB929221094A GB9221094D0 (en) 1991-10-15 1992-10-07 Binding assay employing labelled reagent
PCT/GB1992/001892 WO1993008472A1 (en) 1991-10-15 1992-10-15 Binding assay employing labelled reagent

Publications (2)

Publication Number Publication Date
DE69223980D1 DE69223980D1 (de) 1998-02-12
DE69223980T2 true DE69223980T2 (de) 1998-05-28

Family

ID=26299698

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69223980T Expired - Lifetime DE69223980T2 (de) 1991-10-15 1992-10-15 Bindungstest unter benutzung eines markierten reagens

Country Status (9)

Country Link
US (1) US5516635A (de)
EP (1) EP0608370B1 (de)
JP (1) JP3097866B2 (de)
AT (1) ATE161964T1 (de)
AU (1) AU2872092A (de)
DE (1) DE69223980T2 (de)
DK (1) DK0608370T3 (de)
ES (1) ES2112916T3 (de)
WO (1) WO1993008472A1 (de)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102005062003A1 (de) * 2005-12-22 2007-06-28 Endress + Hauser Conducta Gesellschaft für Mess- und Regeltechnik mbH + Co. KG Vorrichtung und Verfahren zur Detektion und/oder quantitativen Messung eines Zielmediums

Families Citing this family (181)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FI96143C (fi) * 1993-03-16 1996-05-10 Wallac Oy Biospesifinen määritysmenetelmä
GB9326450D0 (en) * 1993-12-24 1994-02-23 Multilyte Ltd Binding assay
US6416714B1 (en) * 1995-04-25 2002-07-09 Discovery Partners International, Inc. Remotely programmable matrices with memories
FI100276B (fi) * 1996-02-06 1997-10-31 Orion Yhtymae Oy Menetelmä analyyttien ei-kilpailevaa määritystä varten
GB9602323D0 (en) * 1996-02-06 1996-04-03 Boehringer Mannheim Gmbh Materials and methods relating to binding assays
US6852487B1 (en) 1996-02-09 2005-02-08 Cornell Research Foundation, Inc. Detection of nucleic acid sequence differences using the ligase detection reaction with addressable arrays
US20020150921A1 (en) * 1996-02-09 2002-10-17 Francis Barany Detection of nucleic acid sequence differences using the ligase detection reaction with addressable arrays
WO1997032212A1 (en) * 1996-03-01 1997-09-04 Beckman Instruments, Inc. System for simultaneously conducting multiple ligand binding assays
US6958245B2 (en) 1996-04-25 2005-10-25 Bioarray Solutions Ltd. Array cytometry
CA2255599C (en) * 1996-04-25 2006-09-05 Bioarray Solutions, Llc Light-controlled electrokinetic assembly of particles near surfaces
US7144119B2 (en) * 1996-04-25 2006-12-05 Bioarray Solutions Ltd. System and method for programmable illumination pattern generation
US6387707B1 (en) * 1996-04-25 2002-05-14 Bioarray Solutions Array Cytometry
US7041510B2 (en) 1996-04-25 2006-05-09 Bioarray Solutions Ltd. System and method for programmable illumination pattern generation
EP1736554B1 (de) * 1996-05-29 2013-10-09 Cornell Research Foundation, Inc. Bestimmung von Unterschieden in der Nukleinsäuresequenz mittels einer Kombination von Ligasebestimmung und Polymerasekettenreaktion
US6133436A (en) 1996-11-06 2000-10-17 Sequenom, Inc. Beads bound to a solid support and to nucleic acids
US6280945B1 (en) 1997-02-21 2001-08-28 Saigene Corporation Universal solid-phase hybridization apparatus
US7622294B2 (en) * 1997-03-14 2009-11-24 Trustees Of Tufts College Methods for detecting target analytes and enzymatic reactions
US20030027126A1 (en) 1997-03-14 2003-02-06 Walt David R. Methods for detecting target analytes and enzymatic reactions
US6327410B1 (en) 1997-03-14 2001-12-04 The Trustees Of Tufts College Target analyte sensors utilizing Microspheres
US6023540A (en) 1997-03-14 2000-02-08 Trustees Of Tufts College Fiber optic sensor with encoded microspheres
US6406845B1 (en) 1997-05-05 2002-06-18 Trustees Of Tuft College Fiber optic biosensor for selectively detecting oligonucleotide species in a mixed fluid sample
DK1019496T3 (da) 1997-07-07 2005-01-10 Medical Res Council In vitro-sorteringsmetode
DE19731465A1 (de) * 1997-07-22 1999-01-28 Boehringer Mannheim Gmbh Verwendung von Kontrollflächen zur Detektion von Störproben in einem Nachweisverfahren
US7115884B1 (en) 1997-10-06 2006-10-03 Trustees Of Tufts College Self-encoding fiber optic sensor
US7348181B2 (en) 1997-10-06 2008-03-25 Trustees Of Tufts College Self-encoding sensor with microspheres
US7157234B2 (en) * 1997-10-24 2007-01-02 Beckman Coulter, Inc. Detection of very low quantities of analyte bound to a solid phase
DE19748489A1 (de) 1997-11-03 1999-05-06 Roche Diagnostics Gmbh Polyethylenglykol-derivatisierte Biomoleküle und deren Verwendung in heterogenen Nachweisverfahren
JP2002502977A (ja) 1998-02-04 2002-01-29 インビトロジェン コーポレイション マイクロアレイとその使用
US6210910B1 (en) 1998-03-02 2001-04-03 Trustees Of Tufts College Optical fiber biosensor array comprising cell populations confined to microcavities
US6395562B1 (en) 1998-04-22 2002-05-28 The Regents Of The University Of California Diagnostic microarray apparatus
US6342395B1 (en) 1998-04-22 2002-01-29 The Regents Of The University Of California Compact assay system with digital information
US8063190B2 (en) * 1998-06-02 2011-11-22 Tom Robin Caine Boyde Nucleic acid-linked conjugates and methods for making and using them
DE19838802A1 (de) * 1998-06-22 1999-12-23 Roche Diagnostics Gmbh Verbesserung von Bindeassays durch Multiepitopanalyse und Kombination von Antigen- und Antikörper-Bestimmung
EP1090298B2 (de) * 1998-06-22 2015-06-24 Roche Diagnostics GmbH Verbesserung von bindeassays durch multiepitopanalyse
ATE423314T1 (de) 1998-06-24 2009-03-15 Illumina Inc Dekodierung von matrixartig-angeordneten sensoren durch mikropartikel
US6780582B1 (en) * 1998-07-14 2004-08-24 Zyomyx, Inc. Arrays of protein-capture agents and methods of use thereof
US20020119579A1 (en) * 1998-07-14 2002-08-29 Peter Wagner Arrays devices and methods of use thereof
US6576478B1 (en) * 1998-07-14 2003-06-10 Zyomyx, Inc. Microdevices for high-throughput screening of biomolecules
US6406921B1 (en) * 1998-07-14 2002-06-18 Zyomyx, Incorporated Protein arrays for high-throughput screening
US20030138973A1 (en) * 1998-07-14 2003-07-24 Peter Wagner Microdevices for screening biomolecules
US7612020B2 (en) * 1998-12-28 2009-11-03 Illumina, Inc. Composite arrays utilizing microspheres with a hybridization chamber
US6429027B1 (en) 1998-12-28 2002-08-06 Illumina, Inc. Composite arrays utilizing microspheres
GB9900298D0 (en) * 1999-01-07 1999-02-24 Medical Res Council Optical sorting method
US6846460B1 (en) * 1999-01-29 2005-01-25 Illumina, Inc. Apparatus and method for separation of liquid phases of different density and for fluorous phase organic syntheses
US6506594B1 (en) * 1999-03-19 2003-01-14 Cornell Res Foundation Inc Detection of nucleic acid sequence differences using the ligase detection reaction with addressable arrays
US7014994B1 (en) 1999-03-19 2006-03-21 Cornell Research Foundation,Inc. Coupled polymerase chain reaction-restriction-endonuclease digestion-ligase detection reaction process
US6355431B1 (en) 1999-04-20 2002-03-12 Illumina, Inc. Detection of nucleic acid amplification reactions using bead arrays
US20060275782A1 (en) 1999-04-20 2006-12-07 Illumina, Inc. Detection of nucleic acid reactions on bead arrays
US20030215821A1 (en) * 1999-04-20 2003-11-20 Kevin Gunderson Detection of nucleic acid reactions on bead arrays
US6544732B1 (en) * 1999-05-20 2003-04-08 Illumina, Inc. Encoding and decoding of array sensors utilizing nanocrystals
WO2000075373A2 (en) 1999-05-20 2000-12-14 Illumina, Inc. Combinatorial decoding of random nucleic acid arrays
US8481268B2 (en) 1999-05-21 2013-07-09 Illumina, Inc. Use of microfluidic systems in the detection of target analytes using microsphere arrays
US8080380B2 (en) * 1999-05-21 2011-12-20 Illumina, Inc. Use of microfluidic systems in the detection of target analytes using microsphere arrays
DE19927783A1 (de) 1999-06-18 2000-12-21 Roche Diagnostics Gmbh Element zur Bestimmung eines Analyts in einer Flüssigkeit, entsprechendes Bestimmungsverfahren unter Verwendung des Elementes sowie Kit zur Bestimmugn eines Analyts
US6645733B1 (en) * 1999-06-25 2003-11-11 Ingeneus Corporation Fluorescent intensity method for assaying binding between proteins or peptides
ATE542916T1 (de) 1999-08-18 2012-02-15 Illumina Inc Methoden zur erzeugung von oligonukleotidlösungen
CA2382436C (en) 1999-08-30 2011-05-17 Illumina, Inc. Methods for improving signal detection from an array
US7167615B1 (en) 1999-11-05 2007-01-23 Board Of Regents, The University Of Texas System Resonant waveguide-grating filters and sensors and methods for making and using same
US8143195B2 (en) * 2000-01-24 2012-03-27 Yingjian Wang Arrays for bringing two or more reagents in contact with one or more biological targets and methods for making and using the arrays
US7429466B2 (en) * 2000-01-24 2008-09-30 Hypromatrix, Inc Methods and arrays for detecting biological molecules
US6913884B2 (en) * 2001-08-16 2005-07-05 Illumina, Inc. Compositions and methods for repetitive use of genomic DNA
US7361488B2 (en) * 2000-02-07 2008-04-22 Illumina, Inc. Nucleic acid detection methods using universal priming
US20050214825A1 (en) * 2000-02-07 2005-09-29 John Stuelpnagel Multiplex sample analysis on universal arrays
US8076063B2 (en) * 2000-02-07 2011-12-13 Illumina, Inc. Multiplexed methylation detection methods
US7582420B2 (en) 2001-07-12 2009-09-01 Illumina, Inc. Multiplex nucleic acid reactions
US7611869B2 (en) * 2000-02-07 2009-11-03 Illumina, Inc. Multiplexed methylation detection methods
AU3806701A (en) 2000-02-07 2001-08-14 Illumina Inc Nucleic acid detection methods using universal priming
JP2003521252A (ja) 2000-02-07 2003-07-15 イルミナ インコーポレイテッド ユニバーサルプライミングを用いる核酸検出方法
US7955794B2 (en) * 2000-09-21 2011-06-07 Illumina, Inc. Multiplex nucleic acid reactions
DE10005301A1 (de) 2000-02-07 2001-08-09 Trutnau Hans Heinrich Multi-Schritt-Kinetik molekularer Interaktionen als analytisches Mess- und Auswerte-Verfahren
EP1257805B1 (de) * 2000-02-10 2015-10-14 Illumina, Inc. Element mit einem substrat mit mehreren immunoassay-stellen zur simultanen analyse mehrerer proben mit hilfe von mikrokugeln, das element enthaltende vorrichtung, und herstellungsverfahren für das element
US6770441B2 (en) * 2000-02-10 2004-08-03 Illumina, Inc. Array compositions and methods of making same
EP1257668B1 (de) 2000-02-16 2008-10-29 Illumina, Inc. Parallele genotypisierung mehrerer patientenproben
AU2001293366A1 (en) 2000-04-14 2001-10-30 Cornell Research Foundation, Inc. Method of designing addressable array for detection of nucleic acid sequence differences using ligase detection reaction
AU5951201A (en) * 2000-05-04 2001-11-12 Univ Yale High density protein arrays for screening of protein activity
US9709559B2 (en) 2000-06-21 2017-07-18 Bioarray Solutions, Ltd. Multianalyte molecular analysis using application-specific random particle arrays
US7892854B2 (en) 2000-06-21 2011-02-22 Bioarray Solutions, Ltd. Multianalyte molecular analysis using application-specific random particle arrays
AU2001288751A1 (en) * 2000-09-05 2002-03-22 Illumina, Inc. Cellular arrays comprising encoded cells
US7057704B2 (en) * 2000-09-17 2006-06-06 Bioarray Solutions Ltd. System and method for programmable illumination pattern generation
AU2001292959A1 (en) * 2000-09-22 2002-04-02 Clontech Laboratories, Inc. Highly sensitive proteomic analysis methods and kits and systems for practicing the same
US20030045005A1 (en) * 2000-10-17 2003-03-06 Michael Seul Light-controlled electrokinetic assembly of particles near surfaces
US20040018491A1 (en) * 2000-10-26 2004-01-29 Kevin Gunderson Detection of nucleic acid reactions on bead arrays
AU2002235170A1 (en) * 2000-11-07 2002-05-21 James O. Bowlby Jr. Method in quantitative analysis of gene and protein expression
US7262063B2 (en) 2001-06-21 2007-08-28 Bio Array Solutions, Ltd. Directed assembly of functional heterostructures
WO2003029490A1 (en) * 2001-10-01 2003-04-10 Yingjian Wang Methods and arrays for detecting biological molecules
KR20040068122A (ko) 2001-10-15 2004-07-30 바이오어레이 솔루션스 리미티드 공동 검색과 효소-매개된 탐지에 의한 다형성 좌위의 다중분석
GB0127564D0 (en) * 2001-11-16 2002-01-09 Medical Res Council Emulsion compositions
US6837171B1 (en) 2002-04-29 2005-01-04 Palmer/Snyder Furniture Company Lightweight table with unitized table top
US8367013B2 (en) * 2001-12-24 2013-02-05 Kimberly-Clark Worldwide, Inc. Reading device, method, and system for conducting lateral flow assays
US20030119203A1 (en) * 2001-12-24 2003-06-26 Kimberly-Clark Worldwide, Inc. Lateral flow assay devices and methods for conducting assays
US7335153B2 (en) * 2001-12-28 2008-02-26 Bio Array Solutions Ltd. Arrays of microparticles and methods of preparation thereof
US7499806B2 (en) * 2002-02-14 2009-03-03 Illumina, Inc. Image processing in microsphere arrays
US20030162178A1 (en) * 2002-02-25 2003-08-28 O'hagan David Variable microarray and methods of detecting one or more anlaytes in a sample
US7223534B2 (en) * 2002-05-03 2007-05-29 Kimberly-Clark Worldwide, Inc. Diffraction-based diagnostic devices
US7214530B2 (en) * 2002-05-03 2007-05-08 Kimberly-Clark Worldwide, Inc. Biomolecule diagnostic devices and method for producing biomolecule diagnostic devices
US7223368B2 (en) * 2002-05-03 2007-05-29 Kimberly-Clark Worldwide, Inc. Diffraction-based diagnostic devices
US7771922B2 (en) * 2002-05-03 2010-08-10 Kimberly-Clark Worldwide, Inc. Biomolecule diagnostic device
US7091049B2 (en) * 2002-06-26 2006-08-15 Kimberly-Clark Worldwide, Inc. Enhanced diffraction-based biosensor devices
AU2003257109A1 (en) * 2002-08-05 2004-02-23 Invitrogen Corporation Compositions and methods for molecular biology
US7285424B2 (en) * 2002-08-27 2007-10-23 Kimberly-Clark Worldwide, Inc. Membrane-based assay devices
US7314763B2 (en) * 2002-08-27 2008-01-01 Kimberly-Clark Worldwide, Inc. Fluidics-based assay devices
DE10245644A1 (de) * 2002-09-30 2004-04-08 Cibitest Gmbh & Co.Kg. Verfahren zum Nachweis von Analyten
US20040259105A1 (en) * 2002-10-03 2004-12-23 Jian-Bing Fan Multiplex nucleic acid analysis using archived or fixed samples
US7526114B2 (en) 2002-11-15 2009-04-28 Bioarray Solutions Ltd. Analysis, secure access to, and transmission of array images
US7781172B2 (en) * 2003-11-21 2010-08-24 Kimberly-Clark Worldwide, Inc. Method for extending the dynamic detection range of assay devices
US20040106190A1 (en) * 2002-12-03 2004-06-03 Kimberly-Clark Worldwide, Inc. Flow-through assay devices
US7247500B2 (en) * 2002-12-19 2007-07-24 Kimberly-Clark Worldwide, Inc. Reduction of the hook effect in membrane-based assay devices
US20040121334A1 (en) * 2002-12-19 2004-06-24 Kimberly-Clark Worldwide, Inc. Self-calibrated flow-through assay devices
CA2513985C (en) * 2003-01-21 2012-05-29 Illumina Inc. Chemical reaction monitor
US6943768B2 (en) 2003-02-21 2005-09-13 Xtellus Inc. Thermal control system for liquid crystal cell
US10533998B2 (en) 2008-07-18 2020-01-14 Bio-Rad Laboratories, Inc. Enzyme quantification
GB0307428D0 (en) 2003-03-31 2003-05-07 Medical Res Council Compartmentalised combinatorial chemistry
GB0307403D0 (en) 2003-03-31 2003-05-07 Medical Res Council Selection by compartmentalised screening
US20060078893A1 (en) 2004-10-12 2006-04-13 Medical Research Council Compartmentalised combinatorial chemistry by microfluidic control
US7851209B2 (en) * 2003-04-03 2010-12-14 Kimberly-Clark Worldwide, Inc. Reduction of the hook effect in assay devices
US20040197819A1 (en) * 2003-04-03 2004-10-07 Kimberly-Clark Worldwide, Inc. Assay devices that utilize hollow particles
US20040248323A1 (en) * 2003-06-09 2004-12-09 Protometrix, Inc. Methods for conducting assays for enzyme activity on protein microarrays
WO2005029705A2 (en) 2003-09-18 2005-03-31 Bioarray Solutions, Ltd. Number coding for identification of subtypes of coded types of solid phase carriers
CA2539824C (en) 2003-09-22 2015-02-03 Xinwen Wang Surface immobilized polyelectrolyte with multiple functional groups capable of covalently bonding to biomolecules
AU2004286252A1 (en) 2003-10-28 2005-05-12 Bioarray Solutions Ltd. Optimization of gene expression analysis using immobilized capture probes
WO2005045060A2 (en) 2003-10-29 2005-05-19 Bioarray Solutions, Ltd. Multiplexed nucleic acid analysis by fragmentation of double-stranded dna
US7713748B2 (en) 2003-11-21 2010-05-11 Kimberly-Clark Worldwide, Inc. Method of reducing the sensitivity of assay devices
US20050112703A1 (en) 2003-11-21 2005-05-26 Kimberly-Clark Worldwide, Inc. Membrane-based lateral flow assay devices that utilize phosphorescent detection
US7943395B2 (en) * 2003-11-21 2011-05-17 Kimberly-Clark Worldwide, Inc. Extension of the dynamic detection range of assay devices
US20050136550A1 (en) * 2003-12-19 2005-06-23 Kimberly-Clark Worldwide, Inc. Flow control of electrochemical-based assay devices
US7943089B2 (en) * 2003-12-19 2011-05-17 Kimberly-Clark Worldwide, Inc. Laminated assay devices
US20050191665A1 (en) * 2003-12-29 2005-09-01 Xing Su Composite organic-inorganic nanoclusters
US20050147963A1 (en) * 2003-12-29 2005-07-07 Intel Corporation Composite organic-inorganic nanoparticles and methods for use thereof
WO2005071401A2 (en) * 2004-01-15 2005-08-04 Chiron Corporation Homogeneous multiplex assay for nucleic acid targets
US20050221339A1 (en) 2004-03-31 2005-10-06 Medical Research Council Harvard University Compartmentalised screening by microfluidic control
EP1735617B1 (de) 2004-04-08 2010-11-10 Roche Diagnostics GmbH Fluoreszenzpolypeptidkomplex einer grösse von 40 bis 500 nm
US7521226B2 (en) 2004-06-30 2009-04-21 Kimberly-Clark Worldwide, Inc. One-step enzymatic and amine detection technique
US7848889B2 (en) 2004-08-02 2010-12-07 Bioarray Solutions, Ltd. Automated analysis of multiplexed probe-target interaction patterns: pattern matching and allele identification
EP1626280B1 (de) * 2004-08-12 2007-02-14 Roche Diagnostics GmbH Verfahren zur Diagnose von Leberfibrose.
EP1626279B1 (de) * 2004-08-12 2008-04-16 Roche Diagnostics GmbH Verfahren zur Diagnose von Leberfibrose
GB0421838D0 (en) 2004-09-30 2004-11-03 Congenia S R L Cancer markers
US7968287B2 (en) 2004-10-08 2011-06-28 Medical Research Council Harvard University In vitro evolution in microfluidic systems
DE102004052729A1 (de) * 2004-10-30 2006-05-04 Roche Diagnostics Gmbh Immunkomplex-spezifsicher Antikörper zur Reduktion des Nullwerts beim Nachweis von Antigen-spezifisch gebundenen Antikörpern einer bestimmten Immunglobulinklasse in Array-Testformaten
KR100601983B1 (ko) * 2005-01-20 2006-07-18 삼성전자주식회사 시료 내 핵산 증폭 저해 물질의 제거 방법
US20060246576A1 (en) 2005-04-06 2006-11-02 Affymetrix, Inc. Fluidic system and method for processing biological microarrays in personal instrumentation
US7439079B2 (en) * 2005-04-29 2008-10-21 Kimberly-Clark Worldwide, Inc. Assay devices having detection capabilities within the hook effect region
US8486629B2 (en) 2005-06-01 2013-07-16 Bioarray Solutions, Ltd. Creation of functionalized microparticle libraries by oligonucleotide ligation or elongation
WO2007081386A2 (en) 2006-01-11 2007-07-19 Raindance Technologies, Inc. Microfluidic devices and methods of use
US9562837B2 (en) 2006-05-11 2017-02-07 Raindance Technologies, Inc. Systems for handling microfludic droplets
US20080014589A1 (en) 2006-05-11 2008-01-17 Link Darren R Microfluidic devices and methods of use thereof
US20080003667A1 (en) * 2006-05-19 2008-01-03 Affymetrix, Inc. Consumable elements for use with fluid processing and detection systems
EP2077912B1 (de) 2006-08-07 2019-03-27 The President and Fellows of Harvard College Fluorkohlenstoffemulsionsstabilisierende tenside
US8772046B2 (en) 2007-02-06 2014-07-08 Brandeis University Manipulation of fluids and reactions in microfluidic systems
US8592221B2 (en) 2007-04-19 2013-11-26 Brandeis University Manipulation of fluids, fluid components and reactions in microfluidic systems
WO2010009365A1 (en) 2008-07-18 2010-01-21 Raindance Technologies, Inc. Droplet libraries
US8528589B2 (en) 2009-03-23 2013-09-10 Raindance Technologies, Inc. Manipulation of microfluidic droplets
GB0913258D0 (en) 2009-07-29 2009-09-02 Dynex Technologies Inc Reagent dispenser
US9523701B2 (en) 2009-07-29 2016-12-20 Dynex Technologies, Inc. Sample plate systems and methods
EP2486409A1 (de) 2009-10-09 2012-08-15 Universite De Strasbourg Markiertes nanomaterial auf siliziumbasis mit verbesserten eigenschaften und seine verwendung
US10837883B2 (en) 2009-12-23 2020-11-17 Bio-Rad Laboratories, Inc. Microfluidic systems and methods for reducing the exchange of molecules between droplets
US9366632B2 (en) 2010-02-12 2016-06-14 Raindance Technologies, Inc. Digital analyte analysis
US10351905B2 (en) 2010-02-12 2019-07-16 Bio-Rad Laboratories, Inc. Digital analyte analysis
WO2011100604A2 (en) 2010-02-12 2011-08-18 Raindance Technologies, Inc. Digital analyte analysis
US9399797B2 (en) 2010-02-12 2016-07-26 Raindance Technologies, Inc. Digital analyte analysis
EP2606362B1 (de) 2010-08-19 2015-09-30 Roche Diagniostics GmbH Assay zur messung der antikörperbindung an einen therapeutischen, monoklonalen antikörper
GB201016403D0 (en) 2010-09-29 2010-11-10 Bath Ventures Novel interaction between staphylococcus aureus Sbi and C3d protiens
EP3447155A1 (de) 2010-09-30 2019-02-27 Raindance Technologies, Inc. Sandwichassays in tröpfchen
WO2012109600A2 (en) 2011-02-11 2012-08-16 Raindance Technologies, Inc. Methods for forming mixed droplets
WO2012112804A1 (en) 2011-02-18 2012-08-23 Raindance Technoligies, Inc. Compositions and methods for molecular labeling
US8841071B2 (en) 2011-06-02 2014-09-23 Raindance Technologies, Inc. Sample multiplexing
US8658430B2 (en) 2011-07-20 2014-02-25 Raindance Technologies, Inc. Manipulating droplet size
TWI476394B (zh) * 2012-04-02 2015-03-11 Univ Chang Gung And a method and method for determining whether a target biomolecule exists in a sample to be measured
WO2014164594A1 (en) 2013-03-11 2014-10-09 Meso Scale Technologies, Llc. Improved methods for conducting multiplexed assays
US11901041B2 (en) 2013-10-04 2024-02-13 Bio-Rad Laboratories, Inc. Digital analysis of nucleic acid modification
US9944977B2 (en) 2013-12-12 2018-04-17 Raindance Technologies, Inc. Distinguishing rare variations in a nucleic acid sequence from a sample
EP3090063B1 (de) 2013-12-31 2019-11-06 Bio-Rad Laboratories, Inc. Verfahren zur detektion von latentem retrovirus
EP3212315A4 (de) 2014-10-31 2018-07-11 Massachusetts Institute of Technology Zusammensetzungen und verfahren zur herstellung von emulsionen
US10060913B2 (en) * 2016-09-19 2018-08-28 Massachusetts Institute Of Technology Systems including janus droplets capable of binding an analyte and changing orientation to provide a detectable change
US11119098B2 (en) 2014-10-31 2021-09-14 Massachusetts Institute Of Technology Systems including Janus droplets
US10005058B2 (en) 2014-10-31 2018-06-26 Massachusetts Institute Of Technology Compositions and methods for arranging colloid phases
CN104714017A (zh) * 2015-02-06 2015-06-17 北京豪迈生物工程有限公司 一种定量检测降钙素原的方法
US10647981B1 (en) 2015-09-08 2020-05-12 Bio-Rad Laboratories, Inc. Nucleic acid library generation methods and compositions
US11415551B2 (en) * 2016-04-26 2022-08-16 Qorvo Biotechnologies, Llc Resonator for detecting single molecule binding
WO2021097275A1 (en) * 2019-11-15 2021-05-20 The Regents Of The University Of Michigan Systems and methods for rapid, sensitive multiplex immunoassays
CN111077316A (zh) * 2019-12-24 2020-04-28 北京博肽未名生物技术有限公司 一种荧光微球与抗体的偶联方法
CN113419059B (zh) * 2021-06-30 2023-09-01 迈克生物股份有限公司 用于化学发光免疫分析方法的封闭剂

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4372745A (en) * 1979-12-19 1983-02-08 Electro-Nucleonics, Inc. Chemical luminescence amplification substrate system for immunochemistry involving microencapsulated fluorescer
US4732847A (en) * 1981-06-09 1988-03-22 University Of Hawaii Monoclonal antibodies for DNA-RNA hybrid complexes and their uses
AU1944283A (en) * 1982-08-27 1984-03-29 Ekins Roger Philip Measurement of analyte concentration
US4663277A (en) * 1983-05-20 1987-05-05 Profile Diagnostic Sciences Inc. Virus detection method and materials
US5171695A (en) * 1986-08-06 1992-12-15 Multilyte Limited Determination of analyte concentration using two labelling markers
SE458968B (sv) * 1987-06-16 1989-05-22 Wallac Oy Biospecifikt analysfoerfarande foer flera analyter i vilket ingaar partikelraekning och maerkning med fluorescerande maerksubstanser
US5132242A (en) * 1987-07-15 1992-07-21 Cheung Sau W Fluorescent microspheres and methods of using them
JPS6435373A (en) * 1987-07-31 1989-02-06 Fujirebio Kk Method and device for high-sensitivity immunoassay
GB8803000D0 (en) * 1988-02-10 1988-03-09 Ekins Roger Philip Determination of ambient concentrations of several analytes
US4978625A (en) * 1987-10-19 1990-12-18 Becton, Dickinson And Company Fluorescence immunoassay using water insoluble dyes
JPH01214760A (ja) * 1988-02-23 1989-08-29 Teikoku Hormone Mfg Co Ltd 免疫学的簡易測定方法
FR2628530B1 (fr) * 1988-03-08 1994-01-28 Chemunex Sa Appareil et procede de detection et de numeration de particules fluorescentes, portees par un support solide
US5252459A (en) * 1988-09-23 1993-10-12 Abbott Laboratories Indicator reagents, diagnostic assays and test kits employing organic polymer latex particles

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102005062003A1 (de) * 2005-12-22 2007-06-28 Endress + Hauser Conducta Gesellschaft für Mess- und Regeltechnik mbH + Co. KG Vorrichtung und Verfahren zur Detektion und/oder quantitativen Messung eines Zielmediums

Also Published As

Publication number Publication date
DK0608370T3 (da) 1998-09-07
WO1993008472A1 (en) 1993-04-29
JPH07500906A (ja) 1995-01-26
AU2872092A (en) 1993-05-21
US5516635A (en) 1996-05-14
EP0608370A1 (de) 1994-08-03
JP3097866B2 (ja) 2000-10-10
ATE161964T1 (de) 1998-01-15
EP0608370B1 (de) 1998-01-07
ES2112916T3 (es) 1998-04-16
DE69223980D1 (de) 1998-02-12

Similar Documents

Publication Publication Date Title
DE69223980T2 (de) Bindungstest unter benutzung eines markierten reagens
JP4997222B2 (ja) 多機能かつ構成可能なアッセイ
DE69022254D1 (de) Liganden-Rezeptor-Assays unter Verwendung eines Schwellenwertes.
CA2387788C (en) Systems and methods for performing magnetic chromatography assays
KR900702368A (ko) 전기화학 발광성 분석
US20070105237A1 (en) Lateral flow assay device with multiple equidistant capture zones
IL101233A (en) Receptor-based screening and identifying methods for amylin agonists and antagonists
DE60018537D1 (de) Teststreifen zur Bestimmung eines Analyts in eine flüssige Probe
WO1999064867A8 (en) Multiple assay method
ATE312199T1 (de) Verfahen und zusammensetzungen zur vermehrung von feststellbaren signalen in spezifischen bindungstests
DE60006975T2 (de) Analytische testvorrichtung mit orientierte durchgehende kanäle besitzendem substrat und verbessertes verfahren und vorrichtung zum gebrauch derselben
ATE203826T1 (de) Verfahren und vorrichtung zur bestimmung eines analyten, insbesondere eines bakteriums, auf magnetischem wege
JPH07503063A (ja) 生体分子検定施行法及び当該方法に使用する固相担体
ATE352786T1 (de) Reagens zur lumineszenz-optischen bestimmung eines analyten
JPH0743382B2 (ja) 分析的アッセイ方法
Eggen et al. The potential of mechanism-based bioanalytical tools in ecotoxicological exposure and effect assessment
DE69406679D1 (de) Verfahren zur bestimmung eines analyts und seine verwendung zur bestimmung von anti-tsh-rezeptorautoantikörpern in einem patientenserum
US20070134736A1 (en) Multi-functional and configurable assay
ATE360206T1 (de) Verfahren zur messung der gesamkonzentration eines analytes
CN101266245A (zh) 纳米金银染增强技术检测痕量二恶英的生物学方法
JP4460779B2 (ja) ホスファターゼ標的毒素のアッセイ
WO2002014869A3 (en) Assay method and device for detecting the presence and concentration of analytes
KR970015747A (ko) 표지에 대한 수용체를 사용하는 동종 유전자 프로브 테스트

Legal Events

Date Code Title Description
8364 No opposition during term of opposition
R071 Expiry of right

Ref document number: 608370

Country of ref document: EP