DE69228436D1 - Monoklonaler Antikörper, der den C-Terminus von hBNP erkennt - Google Patents

Monoklonaler Antikörper, der den C-Terminus von hBNP erkennt

Info

Publication number
DE69228436D1
DE69228436D1 DE69228436T DE69228436T DE69228436D1 DE 69228436 D1 DE69228436 D1 DE 69228436D1 DE 69228436 T DE69228436 T DE 69228436T DE 69228436 T DE69228436 T DE 69228436T DE 69228436 D1 DE69228436 D1 DE 69228436D1
Authority
DE
Germany
Prior art keywords
hbnp
monoclonal antibody
terminus
recognizes
immunoassay
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69228436T
Other languages
English (en)
Other versions
DE69228436T2 (de
Inventor
Tetsuo Tsuji
Ken Inouye
Akira Yamauchi
Masao Kono
Ken Ichi Igano
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Shionogi and Co Ltd
Original Assignee
Shionogi and Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Shionogi and Co Ltd filed Critical Shionogi and Co Ltd
Application granted granted Critical
Publication of DE69228436D1 publication Critical patent/DE69228436D1/de
Publication of DE69228436T2 publication Critical patent/DE69228436T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/26—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against hormones ; against hormone releasing or inhibiting factors
DE69228436T 1991-11-14 1992-11-12 Monoklonaler Antikörper, der den C-Terminus von hBNP erkennt Expired - Lifetime DE69228436T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP3326961A JP2665850B2 (ja) 1991-11-14 1991-11-14 ｈＢＮＰのＣ端を認識するモノクロ−ナル抗体

Publications (2)

Publication Number Publication Date
DE69228436D1 true DE69228436D1 (de) 1999-03-25
DE69228436T2 DE69228436T2 (de) 1999-07-22

Family

ID=18193724

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69228436T Expired - Lifetime DE69228436T2 (de) 1991-11-14 1992-11-12 Monoklonaler Antikörper, der den C-Terminus von hBNP erkennt

Country Status (10)

Country Link
US (2) US6677124B2 (de)
EP (1) EP0542255B1 (de)
JP (1) JP2665850B2 (de)
KR (1) KR100248315B1 (de)
AT (1) ATE176804T1 (de)
DE (1) DE69228436T2 (de)
DK (1) DK0542255T3 (de)
ES (1) ES2129421T3 (de)
GR (1) GR3029904T3 (de)
TW (1) TW230787B (de)

Families Citing this family (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2665850B2 (ja) * 1991-11-14 1997-10-22 塩野義製薬株式会社 ｈＢＮＰのＣ端を認識するモノクロ−ナル抗体
GB9211686D0 (en) * 1992-06-03 1992-07-15 Medisinsk Innovation A S Chemical compounds
DK2292662T3 (da) * 1996-03-04 2014-05-05 Scios Inc ASSAY OG REAGENSER TIL KVANTIFICERING AF hBNP
US6117644A (en) * 1998-06-04 2000-09-12 Ottawa Heart Institute Research Corporation Predicting and detecting cardiac allograft rejection
WO2002038794A2 (en) 2000-11-09 2002-05-16 The Brigham And Women's Hospital, Inc. Cardiovascular disease diagnostic and therapeutic targets
PT1642910E (pt) * 2000-12-05 2012-03-22 Alexion Pharma Inc Anticorpos concebidos de modo racional
US7396917B2 (en) 2000-12-05 2008-07-08 Alexion Pharmaceuticals, Inc. Rationally designed antibodies
US20040253242A1 (en) * 2000-12-05 2004-12-16 Bowdish Katherine S. Rationally designed antibodies
US7524635B2 (en) 2003-04-17 2009-04-28 Biosite Incorporated Methods and compositions for measuring natriuretic peptides and uses thereof
US20030219734A1 (en) * 2001-04-13 2003-11-27 Biosite Incorporated Polypeptides related to natriuretic peptides and methods of their identification and use
ES2685697T3 (es) 2002-05-09 2018-10-10 The Brigham And Women's Hospital, Inc. 1L1RL-1 como un marcador de enfermedades cardiovasculares
KR100945222B1 (ko) 2002-05-13 2010-03-03 벡톤 디킨슨 앤드 컴퍼니 프로테아제 저해제 시료 수집 시스템
US8263325B2 (en) 2002-11-15 2012-09-11 Ottawa Heart Institute Research Corporation Predicting, detecting and monitoring treatment of cardiomyopathies and myocarditis
US7648962B2 (en) * 2002-11-26 2010-01-19 Biocon Limited Natriuretic compounds, conjugates, and uses thereof
EP1569683B1 (de) 2002-11-26 2010-03-03 Biocon Limited Modifizierte natriuretic verbindungen, konjugate und ihre verwendungen
US7476363B2 (en) * 2003-04-03 2009-01-13 Fluidigm Corporation Microfluidic devices and methods of using same
CN101967190A (zh) 2003-05-12 2011-02-09 霍夫曼-拉罗奇有限公司 用结合天然脑钠尿肽前体分子氨基酸38-44的单克隆抗体检测天然脑钠尿肽前体分子的方法
GB2403533A (en) * 2003-06-30 2005-01-05 Orion Corp Atrial natriuretic peptide and brain natriuretic peptide and assays and uses thereof
US20080207505A1 (en) * 2005-01-12 2008-08-28 James Kenneth D Bna Conjugates and Methods of Use
US7731965B2 (en) * 2005-02-17 2010-06-08 Abbott Lab Human ring specific BNP antibodies
US7939069B2 (en) 2005-11-09 2011-05-10 Abbott Laboratories Human BNP immunospecific antibodies
JP5364378B2 (ja) * 2005-11-09 2013-12-11 アボット・ラボラトリーズ ヒトｂｎｐ免疫特異的抗体
ATE476657T1 (de) 2006-04-24 2010-08-15 Critical Care Diagnostics Inc Vorhersage von letalität und detektion von schweren erkrankungen
HUE028594T2 (en) 2006-05-01 2016-12-28 Critical Care Diagnostics Inc Diagnosis of cardiovascular disease
US20080064045A1 (en) 2006-09-07 2008-03-13 Huaiqin Wu Biomarker fragments for the detection of human BNP
ES2401741T3 (es) * 2007-05-08 2013-04-24 Abbott Laboratories Ensayo de péptido natriurético de tipo B humano que tiene una reducida reactividad cruzada con otras formas péptidicas
WO2009086411A2 (en) * 2007-12-27 2009-07-09 Abbott Laboratories Negative mimic antibody for use as a blocking reagent in bnp immunoassays
ES2687401T3 (es) 2008-04-18 2018-10-25 Critical Care Diagnostics, Inc. Predicción del riesgo a sufrir episodios cardíacos adversos graves
US20090286329A1 (en) * 2008-05-19 2009-11-19 Abbott Laboratoires Isolated human autoantibodies to natriuretic peptides and methods and kits for detecting human autoantibodies to natriuretic peptides
US20090286256A1 (en) * 2008-05-19 2009-11-19 Abbott Laboratories Isolated human autoantibodies to natriuretic peptides and methods and kits for detecting human autoantibodies to natriuretic peptides
JP5810514B2 (ja) * 2009-12-07 2015-11-11 東ソー株式会社 タグペプチド
JP6450679B2 (ja) 2012-08-21 2019-01-09 クリティカル ケア ダイアグノスティクス インコーポレイテッド マルチマーカーリスク層別化
CN103869085A (zh) * 2014-04-04 2014-06-18 郑州安图生物工程股份有限公司 一种检测人源n端-b型钠尿肽前体的试剂盒
CN104880446B (zh) * 2015-06-01 2018-11-20 上海凯创生物技术有限公司 一种脑钠肽近红外荧光检测试剂盒及其用途

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4271140A (en) * 1978-01-23 1981-06-02 Baxter Travenol Laboratories, Inc. Method and composition for double receptor, specific binding assays
DE3509958A1 (de) * 1985-03-20 1986-09-25 Bayer Ag, 5090 Leverkusen Monoklonale antikoerper gegen atriale, natriuretische peptide vom menschen
CA1335082C (en) 1987-09-01 1995-04-04 Hiroo Imura Monoclonal antibody recognizing –-hanp and a reagent for immunoassay of –-hanp
JP2665850B2 (ja) * 1991-11-14 1997-10-22 塩野義製薬株式会社 ｈＢＮＰのＣ端を認識するモノクロ−ナル抗体
GB9211686D0 (en) * 1992-06-03 1992-07-15 Medisinsk Innovation A S Chemical compounds
DK2292662T3 (da) * 1996-03-04 2014-05-05 Scios Inc ASSAY OG REAGENSER TIL KVANTIFICERING AF hBNP

Also Published As

Publication number Publication date
US6677124B2 (en) 2004-01-13
JP2665850B2 (ja) 1997-10-22
TW230787B (de) 1994-09-21
EP0542255B1 (de) 1999-02-17
DE69228436T2 (de) 1999-07-22
ES2129421T3 (es) 1999-06-16
GR3029904T3 (en) 1999-07-30
US20040253655A1 (en) 2004-12-16
DK0542255T3 (da) 1999-05-10
JPH05184384A (ja) 1993-07-27
EP0542255A1 (de) 1993-05-19
ATE176804T1 (de) 1999-03-15
KR100248315B1 (ko) 2000-03-15
KR930010191A (ko) 1993-06-22
US20020025559A1 (en) 2002-02-28

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