DE69228436T2 - Monoklonaler Antikörper, der den C-Terminus von hBNP erkennt - Google Patents

Monoklonaler Antikörper, der den C-Terminus von hBNP erkennt

Info

Publication number
DE69228436T2
DE69228436T2 DE69228436T DE69228436T DE69228436T2 DE 69228436 T2 DE69228436 T2 DE 69228436T2 DE 69228436 T DE69228436 T DE 69228436T DE 69228436 T DE69228436 T DE 69228436T DE 69228436 T2 DE69228436 T2 DE 69228436T2
Authority
DE
Germany
Prior art keywords
hbnp
monoclonal antibody
terminus
recognizes
immunoassay
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69228436T
Other languages
English (en)
Other versions
DE69228436D1 (de
Inventor
Tetsuo Tsuji
Ken Inouye
Akira Yamauchi
Masao Kono
Ken Ichi Igano
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Shionogi and Co Ltd
Original Assignee
Shionogi and Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Shionogi and Co Ltd filed Critical Shionogi and Co Ltd
Publication of DE69228436D1 publication Critical patent/DE69228436D1/de
Application granted granted Critical
Publication of DE69228436T2 publication Critical patent/DE69228436T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/26—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against hormones ; against hormone releasing or inhibiting factors
DE69228436T 1991-11-14 1992-11-12 Monoklonaler Antikörper, der den C-Terminus von hBNP erkennt Expired - Lifetime DE69228436T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP3326961A JP2665850B2 (ja) 1991-11-14 1991-11-14 ｈＢＮＰのＣ端を認識するモノクロ−ナル抗体

Publications (2)

Publication Number Publication Date
DE69228436D1 DE69228436D1 (de) 1999-03-25
DE69228436T2 true DE69228436T2 (de) 1999-07-22

Family

ID=18193724

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69228436T Expired - Lifetime DE69228436T2 (de) 1991-11-14 1992-11-12 Monoklonaler Antikörper, der den C-Terminus von hBNP erkennt

Country Status (10)

Country Link
US (2) US6677124B2 (de)
EP (1) EP0542255B1 (de)
JP (1) JP2665850B2 (de)
KR (1) KR100248315B1 (de)
AT (1) ATE176804T1 (de)
DE (1) DE69228436T2 (de)
DK (1) DK0542255T3 (de)
ES (1) ES2129421T3 (de)
GR (1) GR3029904T3 (de)
TW (1) TW230787B (de)

Families Citing this family (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2665850B2 (ja) * 1991-11-14 1997-10-22 塩野義製薬株式会社 ｈＢＮＰのＣ端を認識するモノクロ−ナル抗体
GB9211686D0 (en) * 1992-06-03 1992-07-15 Medisinsk Innovation A S Chemical compounds
CA2248140C (en) * 1996-03-04 2005-02-01 Ronald P. Mischak Assay and reagents for quantifying hbnp
US6117644A (en) * 1998-06-04 2000-09-12 Ottawa Heart Institute Research Corporation Predicting and detecting cardiac allograft rejection
US7432060B2 (en) 2000-11-09 2008-10-07 The Brigham And Women's Hospital, Inc. Methods for diagnosis of cardiovascular disease
US7396917B2 (en) 2000-12-05 2008-07-08 Alexion Pharmaceuticals, Inc. Rationally designed antibodies
US20040253242A1 (en) * 2000-12-05 2004-12-16 Bowdish Katherine S. Rationally designed antibodies
ES2380367T3 (es) * 2000-12-05 2012-05-11 Alexion Pharmaceuticals, Inc. Anticuerpos diseñados racionalmente
US7524635B2 (en) 2003-04-17 2009-04-28 Biosite Incorporated Methods and compositions for measuring natriuretic peptides and uses thereof
US20030219734A1 (en) * 2001-04-13 2003-11-27 Biosite Incorporated Polypeptides related to natriuretic peptides and methods of their identification and use
ES2685697T3 (es) 2002-05-09 2018-10-10 The Brigham And Women's Hospital, Inc. 1L1RL-1 como un marcador de enfermedades cardiovasculares
BR0309976A (pt) 2002-05-13 2005-03-01 Becton Dickinson Co Sistema de coleta de amostra inibidor de protease
US8263325B2 (en) 2002-11-15 2012-09-11 Ottawa Heart Institute Research Corporation Predicting, detecting and monitoring treatment of cardiomyopathies and myocarditis
AU2003297583B2 (en) 2002-11-26 2010-01-14 Biocon, Ltd Modified naturetic compounds, conjugates, and uses thereof
US7648962B2 (en) * 2002-11-26 2010-01-19 Biocon Limited Natriuretic compounds, conjugates, and uses thereof
US7476363B2 (en) * 2003-04-03 2009-01-13 Fluidigm Corporation Microfluidic devices and methods of using same
EP2949669A1 (de) 2003-05-12 2015-12-02 Roche Diagnostics GmbH Verfahren zur erkennung von nativem probnp
GB2403533A (en) 2003-06-30 2005-01-05 Orion Corp Atrial natriuretic peptide and brain natriuretic peptide and assays and uses thereof
WO2006076471A2 (en) * 2005-01-12 2006-07-20 Nobex Corporation Bnp conjugates and methods of use
US7731965B2 (en) 2005-02-17 2010-06-08 Abbott Lab Human ring specific BNP antibodies
US7939069B2 (en) 2005-11-09 2011-05-10 Abbott Laboratories Human BNP immunospecific antibodies
EP1957535A1 (de) 2005-11-09 2008-08-20 Abbott Laboratories Humane bnp-immunspezifische antikörper
ES2646142T3 (es) 2006-04-24 2017-12-12 Critical Care Diagnostics, Inc. Evaluación de la eficacia de un tratamiento en un sujeto en función de los niveles de ST2
PL2021796T3 (pl) * 2006-05-01 2012-07-31 Critical Care Diagnostics Inc Diagnozowanie choroby sercowo-naczyniowej
US20080064045A1 (en) 2006-09-07 2008-03-13 Huaiqin Wu Biomarker fragments for the detection of human BNP
EP2150811B1 (de) * 2007-05-08 2013-01-16 Abbott Laboratories Test für menschliches natriuretisches typ-b-peptid mit verminderter kreuzreaktivität mit anderen peptidformen
US20090203038A1 (en) * 2007-12-27 2009-08-13 Abbott Laboratories Negative Mimic Antibody For Use as a Blocking Reagent In BNP Immunoassays
WO2009129454A2 (en) 2008-04-18 2009-10-22 Critical Care Diagnostics, Inc. Predicting risk of major adverse cardiac events
US20090286256A1 (en) * 2008-05-19 2009-11-19 Abbott Laboratories Isolated human autoantibodies to natriuretic peptides and methods and kits for detecting human autoantibodies to natriuretic peptides
US20090286329A1 (en) * 2008-05-19 2009-11-19 Abbott Laboratoires Isolated human autoantibodies to natriuretic peptides and methods and kits for detecting human autoantibodies to natriuretic peptides
JP5810514B2 (ja) * 2009-12-07 2015-11-11 東ソー株式会社 タグペプチド
CA2882303A1 (en) 2012-08-21 2014-02-27 Critical Care Diagnostics, Inc. Multimarker risk stratification
CN103869085A (zh) * 2014-04-04 2014-06-18 郑州安图生物工程股份有限公司 一种检测人源n端-b型钠尿肽前体的试剂盒
CN104880446B (zh) * 2015-06-01 2018-11-20 上海凯创生物技术有限公司 一种脑钠肽近红外荧光检测试剂盒及其用途

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4271140A (en) * 1978-01-23 1981-06-02 Baxter Travenol Laboratories, Inc. Method and composition for double receptor, specific binding assays
DE3509958A1 (de) * 1985-03-20 1986-09-25 Bayer Ag, 5090 Leverkusen Monoklonale antikoerper gegen atriale, natriuretische peptide vom menschen
CA1335082C (en) 1987-09-01 1995-04-04 Hiroo Imura Monoclonal antibody recognizing –-hanp and a reagent for immunoassay of –-hanp
JP2665850B2 (ja) * 1991-11-14 1997-10-22 塩野義製薬株式会社 ｈＢＮＰのＣ端を認識するモノクロ−ナル抗体
GB9211686D0 (en) * 1992-06-03 1992-07-15 Medisinsk Innovation A S Chemical compounds
CA2248140C (en) * 1996-03-04 2005-02-01 Ronald P. Mischak Assay and reagents for quantifying hbnp

Also Published As

Publication number Publication date
ES2129421T3 (es) 1999-06-16
JP2665850B2 (ja) 1997-10-22
DE69228436D1 (de) 1999-03-25
GR3029904T3 (en) 1999-07-30
TW230787B (de) 1994-09-21
US20040253655A1 (en) 2004-12-16
ATE176804T1 (de) 1999-03-15
EP0542255A1 (de) 1993-05-19
JPH05184384A (ja) 1993-07-27
KR100248315B1 (ko) 2000-03-15
EP0542255B1 (de) 1999-02-17
US20020025559A1 (en) 2002-02-28
KR930010191A (ko) 1993-06-22
US6677124B2 (en) 2004-01-13
DK0542255T3 (da) 1999-05-10

Similar Documents

Publication Publication Date Title
DE69228436T2 (de) Monoklonaler Antikörper, der den C-Terminus von hBNP erkennt
ES2094733T3 (es) Deteccion de enfermedades o disfunciones neurologicas.
ATE114672T1 (de) Peptidzusammensetzung und verfahren zum nachweis von antikörpern gegen htlv-iii.
ES2161751T3 (es) Anticuerpo monoclonal que se une especificamente al endotelio vascular tumoral y usos del mismo.
FI20030652A0 (fi) Parannettu immunomääritys
DK0625912T3 (da) Behandling af inflammatorisk tarmsygdom
DE69028388D1 (de) Monoklonaler antikörper gegen ein neues humanes tumor assoziiertes antigen
DE69333673D1 (de) Epitope von Stress Proteinen
DK0697893T3 (da) Nervetrådproteingenekspression og detektion af Alzheimers sygdom
FR2637600B1 (fr) Peptides et polypeptides provenant de la glande sous maxillaire du rat, anticorps monoclonaux et polyclonaux correspondants, hybridomes correspondants et applications de ces produits au diagnostic, a la detection ou a des fins therapeutiques
ATE230418T1 (de) Monoklonaler antikörper gegen das humane mx- protein mxa
NO962596L (no) Nytt tumorsupressorgen
DE69123724T2 (de) Verfahren zur diagnose von hiv-infektionen
DE69221104T2 (de) Immunoassay für NCA-BT in Blutproben von Brustkrebspatientinnen
RU2013076C1 (ru) Датчик пульсовой волны кровотока
ATE86261T1 (de) Tumorassoziiertes antigen.
ATE231167T1 (de) Pd-ecgf / thymidin phosphorylase spezifischer monoklonaler antikörper
EP0332421A3 (en) Monoclonal antibodies recognizing human psti, hybridomas producing the same, and their preparation and use

Legal Events

Date Code Title Description
R071 Expiry of right

Ref document number: 542255

Country of ref document: EP