DE69231853T2 - Hybridisierung von mit chromophoren und fluorophoren konjugierten polynukleotiden zur erzeugung eines donor-zu-donor energietransfersystems - Google Patents

Hybridisierung von mit chromophoren und fluorophoren konjugierten polynukleotiden zur erzeugung eines donor-zu-donor energietransfersystems

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Publication number
DE69231853T2
DE69231853T2 DE69231853T DE69231853T DE69231853T2 DE 69231853 T2 DE69231853 T2 DE 69231853T2 DE 69231853 T DE69231853 T DE 69231853T DE 69231853 T DE69231853 T DE 69231853T DE 69231853 T2 DE69231853 T2 DE 69231853T2
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Germany
Prior art keywords
donor
chromophores
conjuged
polynucleotids
fluorophors
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Expired - Lifetime
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DE69231853T
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English (en)
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DE69231853D1 (de
Inventor
Michael J Heller
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Nanotronics Imaging Inc
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Nanotronics Inc
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Publication of DE69231853D1 publication Critical patent/DE69231853D1/de
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Publication of DE69231853T2 publication Critical patent/DE69231853T2/de
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Expired - Lifetime legal-status Critical Current

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    • C12Q1/6816Hybridisation assays characterised by the detection means
    • C12Q1/6818Hybridisation assays characterised by the detection means involving interaction of two or more labels, e.g. resonant energy transfer
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DE69231853T 1991-11-07 1992-11-06 Hybridisierung von mit chromophoren und fluorophoren konjugierten polynukleotiden zur erzeugung eines donor-zu-donor energietransfersystems Expired - Lifetime DE69231853T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US79026291A 1991-11-07 1991-11-07
PCT/US1992/009827 WO1993009128A1 (en) 1991-11-07 1992-11-06 Hybridization of polynucleotides conjugated with chromophores and fluorophores to generate donor-to-donor energy transfer system

Publications (2)

Publication Number Publication Date
DE69231853D1 DE69231853D1 (de) 2001-07-05
DE69231853T2 true DE69231853T2 (de) 2001-09-13

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DE69233391T Expired - Lifetime DE69233391D1 (de) 1991-11-07 1992-11-06 Hybridisierung von mit Chromophoren und Fluorophoren konjugierten Polynukleotiden zur Erzeugung eines Donor-Donor Energietransfersystems
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Families Citing this family (382)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6395492B1 (en) * 1990-01-11 2002-05-28 Isis Pharmaceuticals, Inc. Derivatized oligonucleotides having improved uptake and other properties
US7273749B1 (en) * 1990-06-04 2007-09-25 University Of Utah Research Foundation Container for carrying out and monitoring biological processes
US5935522A (en) * 1990-06-04 1999-08-10 University Of Utah Research Foundation On-line DNA analysis system with rapid thermal cycling
US7081226B1 (en) 1996-06-04 2006-07-25 University Of Utah Research Foundation System and method for fluorescence monitoring
US6197508B1 (en) 1990-09-12 2001-03-06 Affymetrix, Inc. Electrochemical denaturation and annealing of nucleic acid
US6652808B1 (en) 1991-11-07 2003-11-25 Nanotronics, Inc. Methods for the electronic assembly and fabrication of devices
US6051380A (en) * 1993-11-01 2000-04-18 Nanogen, Inc. Methods and procedures for molecular biological analysis and diagnostics
US5787032A (en) * 1991-11-07 1998-07-28 Nanogen Deoxyribonucleic acid(DNA) optical storage using non-radiative energy transfer between a donor group, an acceptor group and a quencher group
JP3509859B2 (ja) * 1991-11-07 2004-03-22 ナノトロニクス,インコーポレイテッド 供与体−供与体エネルギー転移系を創製するための発色団および蛍光団でコンジュゲート化されたポリヌクレオチドのハイブリダイゼーション
US6017696A (en) 1993-11-01 2000-01-25 Nanogen, Inc. Methods for electronic stringency control for molecular biological analysis and diagnostics
US6048690A (en) * 1991-11-07 2000-04-11 Nanogen, Inc. Methods for electronic fluorescent perturbation for analysis and electronic perturbation catalysis for synthesis
US6569382B1 (en) * 1991-11-07 2003-05-27 Nanogen, Inc. Methods apparatus for the electronic, homogeneous assembly and fabrication of devices
US6225059B1 (en) 1993-11-01 2001-05-01 Nanogen, Inc. Advanced active electronic devices including collection electrodes for molecular biological analysis and diagnostics
US6331274B1 (en) 1993-11-01 2001-12-18 Nanogen, Inc. Advanced active circuits and devices for molecular biological analysis and diagnostics
US7582421B2 (en) * 1993-11-01 2009-09-01 Nanogen, Inc. Methods for determination of single nucleic acid polymorphisms using a bioelectronic microchip
US7314708B1 (en) * 1998-08-04 2008-01-01 Nanogen, Inc. Method and apparatus for electronic synthesis of molecular structures
US7101661B1 (en) 1993-11-01 2006-09-05 Nanogen, Inc. Apparatus for active programmable matrix devices
US5925517A (en) * 1993-11-12 1999-07-20 The Public Health Research Institute Of The City Of New York, Inc. Detectably labeled dual conformation oligonucleotide probes, assays and kits
US5654419A (en) * 1994-02-01 1997-08-05 The Regents Of The University Of California Fluorescent labels and their use in separations
US6028190A (en) 1994-02-01 2000-02-22 The Regents Of The University Of California Probes labeled with energy transfer coupled dyes
EP0750680B1 (de) 1994-03-15 1999-01-13 Scientific Generics Ltd Elektrochemische denatusierung von doppelsträngiger nukleinsäure
US20070269799A9 (en) * 1994-06-22 2007-11-22 Zhang David Y Nucleic acid amplification methods
WO1996025518A1 (fr) * 1995-02-17 1996-08-22 The Society For Techno-Innovation Of Agriculture, Foresty And Fisheries Sonde destinee a l'analyse de l'acide nucleique et procede de detection
US6008373A (en) 1995-06-07 1999-12-28 Carnegie Mellon University Fluorescent labeling complexes with large stokes shift formed by coupling together cyanine and other fluorochromes capable of resonance energy transfer
US5968745A (en) * 1995-06-27 1999-10-19 The University Of North Carolina At Chapel Hill Polymer-electrodes for detecting nucleic acid hybridization and method of use thereof
US6127127A (en) * 1995-06-27 2000-10-03 The University Of North Carolina At Chapel Hill Monolayer and electrode for detecting a label-bearing target and method of use thereof
US6361951B1 (en) 1995-06-27 2002-03-26 The University Of North Carolina At Chapel Hill Electrochemical detection of nucleic acid hybridization
US6180346B1 (en) 1995-06-27 2001-01-30 The Universtiy Of North Carolina At Chapel Hill Electropolymerizable film, and method of making and use thereof
US6346387B1 (en) 1995-06-27 2002-02-12 Xanthon, Inc. Detection of binding reactions using labels detected by mediated catalytic electrochemistry
US6387625B1 (en) 1995-06-27 2002-05-14 The University Of North Carolina At Chapel Hill Monolayer and electrode for detecting a label-bearing target and method of use thereof
US6132971A (en) * 1995-06-27 2000-10-17 The University Of North Carolina At Chapel Hill Microelectronic device
US5876830A (en) * 1995-09-08 1999-03-02 Board Of Regents Of The University Of Colorado Method of assembly of molecular-sized nets and scaffolding
US6048734A (en) 1995-09-15 2000-04-11 The Regents Of The University Of Michigan Thermal microvalves in a fluid flow method
US5728528A (en) * 1995-09-20 1998-03-17 The Regents Of The University Of California Universal spacer/energy transfer dyes
US20040086917A1 (en) * 1995-09-27 2004-05-06 Nanogen, Inc. Methods for electronic fluorescent perturbation for analysis and electronic perturbation catalysis for synthesis
US10640425B2 (en) 1996-01-19 2020-05-05 Romeo Ilarian Ciuperca Method for predetermined temperature profile controlled concrete curing container and apparatus for same
WO1998010096A1 (en) * 1996-04-12 1998-03-12 The Public Health Research Institute Of The City Of New York, Inc. Detection probes, kits and assays
CA2252048C (en) * 1996-04-12 2008-03-11 The Public Health Research Institute Of The City Of New York, Inc. Detection probes, kits and assays
US7825237B2 (en) * 1996-05-03 2010-11-02 Applied Biosystems, Llc Oligonucleotides and analogs labeled with energy transfer dyes
US5945526A (en) 1996-05-03 1999-08-31 Perkin-Elmer Corporation Energy transfer dyes with enhanced fluorescence
US7388092B2 (en) * 1996-05-03 2008-06-17 Applera Corporation Oligonucleotides and analogs labeled with energy transfer dyes
US6355436B1 (en) 1996-05-17 2002-03-12 L'ecole Centrale De Lyon Method for analyzing biological substances in a conductive liquid medium
EP1179600B1 (de) * 1996-06-04 2005-05-11 University Of Utah Research Foundation Überwachung der Hybridisierung während PCR
JP3400650B2 (ja) * 1996-06-28 2003-04-28 株式会社日立製作所 電気泳動分離検出方法及び装置
US6117635A (en) * 1996-07-16 2000-09-12 Intergen Company Nucleic acid amplification oligonucleotides with molecular energy transfer labels and methods based thereon
US5866336A (en) * 1996-07-16 1999-02-02 Oncor, Inc. Nucleic acid amplification oligonucleotides with molecular energy transfer labels and methods based thereon
US5910410A (en) * 1996-09-06 1999-06-08 Hewlett-Packard Company Dual tag binding assay
AU4321497A (en) * 1996-09-27 1998-04-17 Laboratory Of Molecular Biophotonics Probes for detecting polynucleotides and detection method
AT405103B (de) * 1996-10-16 1999-05-25 Avl Verbrennungskraft Messtech Sensorschicht zur quantitativen bestimmung zumindest einer chemischen komponente einer gasförmigen oder flüssigen probe
US7381525B1 (en) * 1997-03-07 2008-06-03 Clinical Micro Sensors, Inc. AC/DC voltage apparatus for detection of nucleic acids
US7014992B1 (en) * 1996-11-05 2006-03-21 Clinical Micro Sensors, Inc. Conductive oligomers attached to electrodes and nucleoside analogs
US6096273A (en) * 1996-11-05 2000-08-01 Clinical Micro Sensors Electrodes linked via conductive oligomers to nucleic acids
US6706473B1 (en) 1996-12-06 2004-03-16 Nanogen, Inc. Systems and devices for photoelectrophoretic transport and hybridization of oligonucleotides
CA2276462C (en) * 1996-12-31 2007-06-12 Genometrix Incorporated Multiplexed molecular analysis system apparatus and method
EP1666609B1 (de) * 1997-02-28 2012-09-26 Quest Diagnostics Investments Incorporated Fluoreszens-Energie-Transfer durch kompetitive Hybridisierung
US7803528B1 (en) 1997-02-28 2010-09-28 Quest Diagnostics Incorporated Fluorescence energy transfer by competitive hybridization
US6391558B1 (en) 1997-03-18 2002-05-21 Andcare, Inc. Electrochemical detection of nucleic acid sequences
GB9707996D0 (en) * 1997-04-21 1997-06-11 Univ Cambridge Tech Screening
US6013459A (en) 1997-06-12 2000-01-11 Clinical Micro Sensors, Inc. Detection of analytes using reorganization energy
JPH1189598A (ja) * 1997-09-18 1999-04-06 Hitachi Software Eng Co Ltd 蛍光標識プローブ及びハイブリダイゼーション検出方法
US20030219803A1 (en) * 1997-12-15 2003-11-27 Somalogic, Incorporated Homogeneous detection of a target through nucleic acid ligand-ligand beacon interaction
AU3909199A (en) 1997-12-15 1999-07-05 Nexstar Pharmaceuticals, Inc. Homogeneous detection of a target through nucleic acid ligand-ligand beacon interaction
US20100105572A1 (en) * 1997-12-19 2010-04-29 Kris Richard M High throughput assay system
US20030039967A1 (en) * 1997-12-19 2003-02-27 Kris Richard M. High throughput assay system using mass spectrometry
US20030096232A1 (en) 1997-12-19 2003-05-22 Kris Richard M. High throughput assay system
US6365346B1 (en) * 1998-02-18 2002-04-02 Dade Behring Inc. Quantitative determination of nucleic acid amplification products
US6582962B1 (en) * 1998-02-27 2003-06-24 Ventana Medical Systems, Inc. Automated molecular pathology apparatus having independent slide heaters
US6230306B1 (en) 1998-04-17 2001-05-08 Lsi Logic Corporation Method and apparatus for minimization of process defects while routing
US6780591B2 (en) * 1998-05-01 2004-08-24 Arizona Board Of Regents Method of determining the nucleotide sequence of oligonucleotides and DNA molecules
US7875440B2 (en) 1998-05-01 2011-01-25 Arizona Board Of Regents Method of determining the nucleotide sequence of oligonucleotides and DNA molecules
US8198096B2 (en) * 1998-05-05 2012-06-12 Massachusetts Institute Of Technology Emissive polymers and devices incorporating these polymers
US20050147534A1 (en) * 1998-05-05 2005-07-07 Massachusetts Institute Of Technology Emissive sensors and devices incorporating these sensors
EP1080162B1 (de) 1998-05-05 2004-03-10 Massachusetts Institute Of Technology Lichtemittierende polymere und vorrichtungen, die diese enthalten
US7105552B2 (en) * 1998-05-08 2006-09-12 Theracos, Inc. Heterocyclic analogs of diphenylethylene compounds
US6331633B1 (en) 1998-05-08 2001-12-18 Calyx Therapeutics Inc. Heterocyclic analogs of diphenylethylene compounds
US6624197B1 (en) 1998-05-08 2003-09-23 Calyx Therapeutics, Inc. Diphenylethylene compounds
US6245814B1 (en) 1998-05-08 2001-06-12 Calyx Therapeutics, Inc. Diphenylethylene compounds
US6768000B1 (en) * 1998-06-12 2004-07-27 Intergen Company Multi-fluorescent hairpin energy transfer oligonucleotides
GB9812768D0 (en) 1998-06-13 1998-08-12 Zeneca Ltd Methods
US6761816B1 (en) 1998-06-23 2004-07-13 Clinical Micro Systems, Inc. Printed circuit boards with monolayers and capture ligands
US7087148B1 (en) 1998-06-23 2006-08-08 Clinical Micro Sensors, Inc. Binding acceleration techniques for the detection of analytes
US6037130A (en) * 1998-07-28 2000-03-14 The Public Health Institute Of The City Of New York, Inc. Wavelength-shifting probes and primers and their use in assays and kits
DE19840531C2 (de) * 1998-08-28 2003-05-15 Roboscreen Ges Fuer Molekulare Mit Nukleinsäuren beschichtete Reaktionsräume, Verfahren zu ihrer Herstellung und ihre Verwendung
GB9819418D0 (en) * 1998-09-07 1998-10-28 Secr Defence Amplification method
US6703228B1 (en) 1998-09-25 2004-03-09 Massachusetts Institute Of Technology Methods and products related to genotyping and DNA analysis
US7160869B2 (en) 1998-12-16 2007-01-09 University Of Saskatchewan Biologically active metal-containing nucleic acids
US7468250B2 (en) * 1998-12-23 2008-12-23 Rutgers, The State University Of New Jersey Methods and kits for screening nucleic acid duplex stability
US6815163B1 (en) * 1998-12-23 2004-11-09 Rutgers, The State University Methods and kits for screening nucleic acid duplex stability
US6833267B1 (en) * 1998-12-30 2004-12-21 Clinical Micro Sensors, Inc. Tissue collection devices containing biosensors
JP4454155B2 (ja) 1999-01-08 2010-04-21 アプライド バイオシステムズ, エルエルシー 化学種を接触させるためのファイバーアレイならびにファイバーアレイを使用および作製する方法
US20050026209A1 (en) * 1999-01-08 2005-02-03 Vann Charles S. Optical fiber bundle for detecting binding of chemical species
US7595189B2 (en) * 1999-01-08 2009-09-29 Applied Biosystems, Llc Integrated optics fiber array
WO2000047600A1 (en) * 1999-02-10 2000-08-17 University Of Maryland Photo-induced nucleic acid hybridization
US6294063B1 (en) * 1999-02-12 2001-09-25 Board Of Regents, The University Of Texas System Method and apparatus for programmable fluidic processing
US7407978B2 (en) * 1999-04-06 2008-08-05 Theracos, Inc. Heterocyclic analogs of diphenylethylene compounds
US6942771B1 (en) 1999-04-21 2005-09-13 Clinical Micro Sensors, Inc. Microfluidic systems in the electrochemical detection of target analytes
US20020177135A1 (en) * 1999-07-27 2002-11-28 Doung Hau H. Devices and methods for biochip multiplexing
US6238909B1 (en) * 1999-05-04 2001-05-29 Motorola, Inc. Method and apparatus for obtaining electric field-enhanced bioconjugation
AU5882000A (en) * 1999-06-22 2001-01-09 Invitrogen Corporation Improved primers and methods for the detection and discrimination of nucleic acids
US6818395B1 (en) * 1999-06-28 2004-11-16 California Institute Of Technology Methods and apparatus for analyzing polynucleotide sequences
US7501245B2 (en) * 1999-06-28 2009-03-10 Helicos Biosciences Corp. Methods and apparatuses for analyzing polynucleotide sequences
WO2001006505A1 (en) * 1999-07-15 2001-01-25 Trid Store Ip, L.L.C. Multilayer fluorescent optical disc with photosensitive fluorescent material
EP1218541B1 (de) 1999-07-26 2008-12-10 Clinical Micro Sensors, Inc. Nukelinsäuresequenzbestimmung mittels elektronischem nachweis
US6506887B1 (en) * 1999-07-29 2003-01-14 Somalogic, Incorporated Conditional-selex
US6358684B1 (en) * 1999-08-27 2002-03-19 Pe Corporation UV excitable fluorescent energy transfer dyes
US20020002200A1 (en) * 2000-02-04 2002-01-03 Bishwagit Nag Novel diphenylethylene compounds
US20080108825A1 (en) * 1999-11-08 2008-05-08 Theracos, Inc. Compounds for treatment of inflammation, diabetes and related disorders
US7323496B2 (en) * 1999-11-08 2008-01-29 Theracos, Inc. Compounds for treatment of inflammation, diabetes and related disorders
US6525093B1 (en) * 1999-11-08 2003-02-25 Calyx Therapeutics Inc. Compounds to treat diabetes and associated conditions
US6727356B1 (en) 1999-12-08 2004-04-27 Epoch Pharmaceuticals, Inc. Fluorescent quenching detection reagents and methods
US20040081959A9 (en) * 1999-12-08 2004-04-29 Epoch Biosciences, Inc. Fluorescent quenching detection reagents and methods
US20010046674A1 (en) * 2000-02-03 2001-11-29 Andrew Ellington Signaling aptamers that transduce molecular recognition to a differential signal
US20080103302A1 (en) * 2000-02-04 2008-05-01 Theracos, Inc. Compounds for treatment of inflammation, diabetes and related disorders
US6824669B1 (en) 2000-02-17 2004-11-30 Motorola, Inc. Protein and peptide sensors using electrical detection methods
JP2003525631A (ja) * 2000-03-06 2003-09-02 リボザイム・ファーマシューティカルズ・インコーポレーテッド 核酸センサー分子
US7455975B2 (en) * 2000-04-14 2008-11-25 Esa Biosciences, Inc. Electrochemical detection of nucleic acid sequences
US6602400B1 (en) 2000-06-15 2003-08-05 Motorola, Inc. Method for enhanced bio-conjugation events
US7846733B2 (en) 2000-06-26 2010-12-07 Nugen Technologies, Inc. Methods and compositions for transcription-based nucleic acid amplification
US6984522B2 (en) * 2000-08-03 2006-01-10 Regents Of The University Of Michigan Isolation and use of solid tumor stem cells
US6783814B2 (en) 2000-08-21 2004-08-31 Massachusetts Institute Of Technology Polymers with high internal free volume
US6849407B2 (en) 2000-08-31 2005-02-01 Mayo Foundation For Medical Education And Research Detection of varicella-zoster virus
US20040185464A1 (en) * 2000-09-15 2004-09-23 Kris Richard M. High throughput assay system
US6815164B2 (en) 2000-10-06 2004-11-09 Nugen Technologies, Inc. Methods and probes for detection and/or quantification of nucleic acid sequences
AU2002241803A1 (en) * 2000-10-20 2002-06-18 The Board Of Trustees Of The Leland Stanford Junior University Transient electrical signal based methods and devices for characterizing molecular interaction and/or motion in a sample
WO2002048402A2 (en) 2000-12-13 2002-06-20 Nugen Technologies, Inc. Methods and compositions for generation of multiple copies of nucleic acid sequences and methods of detection thereof
WO2002057479A2 (en) * 2000-12-27 2002-07-25 Invitrogen Corporation Primers and methods for the detection and discrimination of nucleic acids
ATE465272T1 (de) * 2001-01-31 2010-05-15 Mayo Foundation Nachweis von herpex-simplex-virus
US20030165866A1 (en) * 2001-01-31 2003-09-04 Cockerill Franklin R. Detection of bordetella
US6692700B2 (en) 2001-02-14 2004-02-17 Handylab, Inc. Heat-reduction methods and systems related to microfluidic devices
NZ528348A (en) * 2001-02-27 2007-07-27 Virco Bvba Circular probe amplification (CPA) using closed circular padlock probe molecules and energy-transfer primers
ZA200210369B (en) 2001-03-09 2004-07-08 Nugen Technologies Inc Methods and compositions for amplification or RNA sequences.
US8895311B1 (en) 2001-03-28 2014-11-25 Handylab, Inc. Methods and systems for control of general purpose microfluidic devices
US6575188B2 (en) 2001-07-26 2003-06-10 Handylab, Inc. Methods and systems for fluid control in microfluidic devices
US7010391B2 (en) 2001-03-28 2006-03-07 Handylab, Inc. Methods and systems for control of microfluidic devices
US6852287B2 (en) 2001-09-12 2005-02-08 Handylab, Inc. Microfluidic devices having a reduced number of input and output connections
US7192557B2 (en) 2001-03-28 2007-03-20 Handylab, Inc. Methods and systems for releasing intracellular material from cells within microfluidic samples of fluids
US7323140B2 (en) 2001-03-28 2008-01-29 Handylab, Inc. Moving microdroplets in a microfluidic device
US7270786B2 (en) 2001-03-28 2007-09-18 Handylab, Inc. Methods and systems for processing microfluidic samples of particle containing fluids
US7829025B2 (en) 2001-03-28 2010-11-09 Venture Lending & Leasing Iv, Inc. Systems and methods for thermal actuation of microfluidic devices
EP1392362B1 (de) * 2001-05-07 2008-09-17 Mayo Foundation For Medical Education And Research Nachweis von Legionella durch ein PCR und FRET verwendendes Verfahren
EP1389350A1 (de) * 2001-05-24 2004-02-18 University of Saskatchewan Technologies Inc. Nukleinsäure-schaltkreiselemente und -methoden
AU2002327184A1 (en) * 2001-06-27 2003-03-03 The Uab Research Foundation Biophotonic sensors and methods of use thereof
DE10133308A1 (de) * 2001-07-12 2003-01-23 Praenadia Gmbh Verfahren zum Nachweis einer Nukleinsäure
US20030022150A1 (en) * 2001-07-24 2003-01-30 Sampson Jeffrey R. Methods for detecting a target molecule
US20030148314A1 (en) * 2001-08-01 2003-08-07 Millennium Pharmaceuticals, Inc. Compositions, kits, and methods for identification, assessment, prevention, and therapy of colon cancer
US6593091B2 (en) * 2001-09-24 2003-07-15 Beckman Coulter, Inc. Oligonucleotide probes for detecting nucleic acids through changes in flourescence resonance energy transfer
US7774711B2 (en) 2001-09-28 2010-08-10 Aol Inc. Automatic categorization of entries in a contact list
US20030082563A1 (en) * 2001-10-15 2003-05-01 Bell Constance A. Detection of bacillus anthracis
US20030165859A1 (en) * 2001-10-23 2003-09-04 Invitrogen Corporation Primers and methods for the detection and discrimination of nucleic acids
US20040086924A1 (en) * 2001-10-26 2004-05-06 Research Development Foundation In vitro selection of signaling aptamers
ATE328119T1 (de) * 2001-11-02 2006-06-15 Roche Diagnostics Gmbh Nachweis von variola virus
DE10153829A1 (de) * 2001-11-05 2003-05-28 Bayer Ag Assay basierend auf dotierten Nanoteilchen
WO2003042697A1 (en) * 2001-11-14 2003-05-22 Genospectra, Inc. Biochemical analysis system with combinatorial chemistry applications
US7462325B2 (en) * 2001-11-30 2008-12-09 Nomadics, Inc. Luminescent polymer particles
US20040034223A1 (en) * 2002-02-07 2004-02-19 Covalent Partners, Llc. Amphiphilic molecular modules and constructs based thereon
CN1646501A (zh) * 2002-02-07 2005-07-27 科瓦伦特合伙责任有限公司 纳米膜和薄膜组合物
US6593093B1 (en) * 2002-02-20 2003-07-15 Mayo Foundation For Medical Education And Research Detection of group a Streptococcus
GB0205455D0 (en) 2002-03-07 2002-04-24 Molecular Sensing Plc Nucleic acid probes, their synthesis and use
US20050065330A1 (en) * 2002-04-24 2005-03-24 The Cleveland Clinic Foundation Identification of Histoplasma capsulatum using a PCR assay
US20030215814A1 (en) * 2002-05-17 2003-11-20 Cockerill Franklin R. Detection of Shiga toxin- or Shiga-like toxin-producing organisms
WO2003102239A2 (en) * 2002-05-31 2003-12-11 Secretary, Department Of Atomic Energy Met/fret based method of target nucleic acid detection whereby the donor/acceptor moieties are on complementary strands
JP2005529606A (ja) * 2002-06-12 2005-10-06 データスコープ・インベストメント・コーポレイション ポリマー標識分子
AU2003269913A1 (en) * 2002-07-15 2004-02-02 Massachusetts Institute Of Technology Emissive, high charge transport polymers
US7601493B2 (en) * 2002-07-26 2009-10-13 Nanogen, Inc. Methods and apparatus for screening and detecting multiple genetic mutations
EP1389638A1 (de) * 2002-08-06 2004-02-18 Roche Diagnostics GmbH Verbesserte Proben für FRET
EP1403382A3 (de) * 2002-08-06 2004-05-06 Roche Diagnostics GmbH Verbesserte Proben für FRET
US20040106741A1 (en) * 2002-09-17 2004-06-03 Kriesel Joshua W. Nanofilm compositions with polymeric components
JP4694201B2 (ja) * 2002-09-20 2011-06-08 インテグレイテッド ディーエヌエイ テクノロジーズ インコーポレイテッド アントラキノン消光色素、それらの製造方法及び使用
US7074598B2 (en) * 2002-09-25 2006-07-11 Mayo Foundation For Medical Education And Research Detection of vancomycin-resistant enterococcus spp.
US7365176B2 (en) * 2002-09-26 2008-04-29 Mayo Foundation For Medical Education And Research Detection of Epstein-Barr virus
US7074599B2 (en) * 2002-09-27 2006-07-11 Mayo Foundation For Medical Education And Research Detection of mecA-containing Staphylococcus spp.
EP1405920A3 (de) * 2002-10-02 2004-04-14 Roche Diagnostics GmbH Verbesserte FRET Methode
US20070184453A1 (en) * 2002-10-02 2007-08-09 Roche Molecular Systems, Inc Fret process
US20040101860A1 (en) * 2002-11-27 2004-05-27 Jones Alison M. Predicting animal performance
US20040259226A1 (en) * 2003-05-30 2004-12-23 Robey W. Wade Monitoring for and detecting microbes used in bioterrorism
US20040121337A1 (en) * 2002-12-19 2004-06-24 Nomadics, Inc. Luminescent polymers and methods of use thereof
US7560231B2 (en) * 2002-12-20 2009-07-14 Roche Molecular Systems, Inc. Mannitol and glucitol derivatives
US7781163B2 (en) 2003-01-08 2010-08-24 Lesley Davenport G-quadruplex binding assays and compounds therefor
CN100439515C (zh) * 2003-03-03 2008-12-03 清华大学 一种核酸分析芯片实验室系统与应用
US7282331B2 (en) * 2003-03-18 2007-10-16 Advandx, Inc. Method for improved specificity in probe based assays
US20040185446A1 (en) * 2003-03-18 2004-09-23 Jones Alison M. Cpn60 targets for quantification of microbial species
US20040185434A1 (en) * 2003-03-21 2004-09-23 Robey W. Wade Detecting microbial contamination in animal by-products
US20040185454A1 (en) * 2003-03-21 2004-09-23 Jones Alison M. Identification and quantification of microbial species in a sample
CA2463719A1 (en) * 2003-04-05 2004-10-05 F. Hoffmann-La Roche Ag Nucleotide analogs with six membered rings
WO2004092418A2 (en) 2003-04-14 2004-10-28 Nugen Technologies, Inc. Global amplification using a randomly primed composite primer
ATE366108T1 (de) 2003-05-20 2007-07-15 Bayer Pharmaceuticals Corp Diaryl-harnstoffe für durch pdgfr vermittelte krankheiten
US20040241662A1 (en) * 2003-05-30 2004-12-02 Robey W. Wade Detecting microbial contamination in grain and related products
US20050170367A1 (en) * 2003-06-10 2005-08-04 Quake Stephen R. Fluorescently labeled nucleoside triphosphates and analogs thereof for sequencing nucleic acids
ATE485303T1 (de) * 2003-06-20 2010-11-15 Mayo Foundation Isoformen von gehirn-natriuretischem peptid
US20070269803A1 (en) * 2003-06-26 2007-11-22 Khalil Arar Fluorogenic Nucleic Acid Probes Including Lna for Methods to Detect and/or Quantify Nucleic Acid Analytes
GB0315121D0 (en) * 2003-06-27 2003-08-06 Matforsk Norwegian Food Res In Methods of nucleic acid analysis
US7731906B2 (en) 2003-07-31 2010-06-08 Handylab, Inc. Processing particle-containing samples
US20060040275A1 (en) * 2003-10-16 2006-02-23 David Rosmarin C-shaped probe
US7169560B2 (en) 2003-11-12 2007-01-30 Helicos Biosciences Corporation Short cycle methods for sequencing polynucleotides
WO2005049849A2 (en) * 2003-11-14 2005-06-02 Integrated Dna Technologies, Inc. Fluorescence quenching azo dyes, their methods of preparation and use
WO2005054441A2 (en) * 2003-12-01 2005-06-16 California Institute Of Technology Device for immobilizing chemical and biomedical species and methods of using same
JP5162133B2 (ja) 2003-12-03 2013-03-13 アボット・ラボラトリーズ 二本鎖直鎖核酸プローブ及びその使用
DE602005024234D1 (de) * 2004-02-10 2010-12-02 Roche Diagnostics Gmbh Neue primer und sonden zum nachweis von parvovirus b19
EP2248911A1 (de) 2004-02-19 2010-11-10 Helicos Biosciences Corporation Verfahren und Zusammensetzungen zur Analyse von Polynukleotidsequenzen
US20060046258A1 (en) * 2004-02-27 2006-03-02 Lapidus Stanley N Applications of single molecule sequencing
KR100906749B1 (ko) * 2004-03-25 2009-07-09 (주)바이오니아 인터컬레이팅 형광염료가 표지된 프로브를 이용한 핵산 증폭 측정 방법
US20050233332A1 (en) * 2004-04-14 2005-10-20 Collis Matthew P Multiple fluorophore detector system
US20050239085A1 (en) * 2004-04-23 2005-10-27 Buzby Philip R Methods for nucleic acid sequence determination
AU2005241080B2 (en) 2004-05-03 2011-08-11 Handylab, Inc. Processing polynucleotide-containing samples
US8852862B2 (en) 2004-05-03 2014-10-07 Handylab, Inc. Method for processing polynucleotide-containing samples
US20070117104A1 (en) * 2005-11-22 2007-05-24 Buzby Philip R Nucleotide analogs
WO2006007207A2 (en) * 2004-05-25 2006-01-19 Helicos Biosciences Corporation Methods and devices for nucleic acid sequence determination
US7476734B2 (en) * 2005-12-06 2009-01-13 Helicos Biosciences Corporation Nucleotide analogs
US20070117103A1 (en) * 2005-11-22 2007-05-24 Buzby Philip R Nucleotide analogs
US8974652B2 (en) * 2004-05-28 2015-03-10 Board Of Regents, The University Of Texas System Programmable fluidic processors
US8655370B2 (en) * 2004-06-25 2014-02-18 Qualcomm Incorporated Geographical location information sharing among wireless devices
KR100724314B1 (ko) 2004-07-22 2007-06-04 주식회사 엘지생명과학 생체감지물질이 고정된 광결정구 및 이의 제조방법 및이용방법
US20060024678A1 (en) * 2004-07-28 2006-02-02 Helicos Biosciences Corporation Use of single-stranded nucleic acid binding proteins in sequencing
FR2874811B1 (fr) * 2004-09-03 2006-11-24 Anteis Sa Dispositif oculaire antiphotophobie, et son procede de preparation
US8617819B2 (en) 2004-09-17 2013-12-31 Massachusetts Institute Of Technology Polymers for analyte detection
US7828954B2 (en) * 2004-09-21 2010-11-09 Gamida For Life B.V. Electrode based patterning of thin film self-assembled nanoparticles
BRPI0516955A (pt) 2004-09-24 2008-09-30 Ingeneus Inc ensaio genÈmico
US20060067889A1 (en) * 2004-09-27 2006-03-30 Light Sciences Corporation Singlet oxygen photosensitizers activated by target binding enhancing the selectivity of targeted PDT agents
US20090197249A1 (en) 2004-11-01 2009-08-06 George Mason University Compositions and methods for diagnosing colon disorders
US20060118754A1 (en) * 2004-12-08 2006-06-08 Lapen Daniel C Stabilizing a polyelectrolyte multilayer
US7220549B2 (en) * 2004-12-30 2007-05-22 Helicos Biosciences Corporation Stabilizing a nucleic acid for nucleic acid sequencing
US20060172328A1 (en) * 2005-01-05 2006-08-03 Buzby Philip R Methods and compositions for correcting misincorporation in a nucleic acid synthesis reaction
US7482120B2 (en) * 2005-01-28 2009-01-27 Helicos Biosciences Corporation Methods and compositions for improving fidelity in a nucleic acid synthesis reaction
WO2006089268A2 (en) * 2005-02-18 2006-08-24 The University Of North Carolina At Chapel Hill Gene and cognate protein profiles and methods to determine connective tissue markers in normal and pathologic conditions
JP2006246854A (ja) * 2005-03-14 2006-09-21 Kyoto Univ 光増感還元反応を利用した遺伝子検出方法および遺伝子検出キット
DE102005000021A1 (de) * 2005-03-16 2006-09-21 Köhler, Thomas, Dr. Verfahren und Testkit zur Detektion von Ziel-Nukleinsäuren
US20070026423A1 (en) * 2005-03-16 2007-02-01 Thomas Koehler Method and test kit for the detection of target nucleic acids
WO2006127507A2 (en) 2005-05-20 2006-11-30 Integrated Dna Technologies, Inc. Compounds and methods for labeling oligonucleotides
US20060263790A1 (en) * 2005-05-20 2006-11-23 Timothy Harris Methods for improving fidelity in a nucleic acid synthesis reaction
US7666593B2 (en) 2005-08-26 2010-02-23 Helicos Biosciences Corporation Single molecule sequencing of captured nucleic acids
CA2621267A1 (en) 2005-09-07 2007-03-15 Nugen Technologies, Inc. Improved nucleic acid amplification procedure
US7569367B2 (en) 2005-09-07 2009-08-04 Roche Diagnostics Operations, Inc. Nucleic acid preparation from whole blood for use in diagnosis of transmissible spongiform encephalopathy
WO2007039301A2 (en) 2005-10-05 2007-04-12 Roche Diagnostics Gmbh Non-fluorescent energy transfer
US8123834B2 (en) 2005-10-06 2012-02-28 The Board Of Trustees Of The University Of Illinois High gain selective metal organic framework preconcentrators
US20070128610A1 (en) * 2005-12-02 2007-06-07 Buzby Philip R Sample preparation method and apparatus for nucleic acid sequencing
US7981606B2 (en) * 2005-12-21 2011-07-19 Roche Molecular Systems, Inc. Control for nucleic acid testing
US20080309926A1 (en) * 2006-03-08 2008-12-18 Aaron Weber Systems and methods for reducing detected intensity non uniformity in a laser beam
US7397546B2 (en) * 2006-03-08 2008-07-08 Helicos Biosciences Corporation Systems and methods for reducing detected intensity non-uniformity in a laser beam
US10900066B2 (en) 2006-03-24 2021-01-26 Handylab, Inc. Microfluidic system for amplifying and detecting polynucleotides in parallel
US8088616B2 (en) 2006-03-24 2012-01-03 Handylab, Inc. Heater unit for microfluidic diagnostic system
JP5415253B2 (ja) 2006-03-24 2014-02-12 ハンディラブ・インコーポレーテッド 微小流体サンプルを処理するための一体化システム及びその使用方法
US7998708B2 (en) 2006-03-24 2011-08-16 Handylab, Inc. Microfluidic system for amplifying and detecting polynucleotides in parallel
US8883490B2 (en) 2006-03-24 2014-11-11 Handylab, Inc. Fluorescence detector for microfluidic diagnostic system
US11806718B2 (en) 2006-03-24 2023-11-07 Handylab, Inc. Fluorescence detector for microfluidic diagnostic system
US20070238095A1 (en) * 2006-04-11 2007-10-11 Mayo Foundation For Medical Education And Research , A Minnesota Corporation Detection of Influenza A Virus
US20070238093A1 (en) * 2006-04-11 2007-10-11 Espy Mark J Detection of influenza A virus
US7880026B2 (en) * 2006-04-14 2011-02-01 The Board Of Trustees Of The University Of Illinois MOF synthesis method
GB0609370D0 (en) * 2006-05-11 2006-06-21 Mock Graham A Process for cross-linking macromolecules
US8158437B2 (en) * 2006-08-04 2012-04-17 Massachusetts Institute Of Technology Luminescent detection of hydrazine and hydrazine derivatives
WO2008021872A1 (en) 2006-08-08 2008-02-21 Mayo Foundation For Medical Education And Research Diuretic and natriuretic polypeptides
US8097419B2 (en) 2006-09-12 2012-01-17 Longhorn Vaccines & Diagnostics Llc Compositions and method for rapid, real-time detection of influenza A virus (H1N1) swine 2009
US8652782B2 (en) 2006-09-12 2014-02-18 Longhorn Vaccines & Diagnostics, Llc Compositions and methods for detecting, identifying and quantitating mycobacterial-specific nucleic acids
US9481912B2 (en) 2006-09-12 2016-11-01 Longhorn Vaccines And Diagnostics, Llc Compositions and methods for detecting and identifying nucleic acid sequences in biological samples
US8080645B2 (en) 2007-10-01 2011-12-20 Longhorn Vaccines & Diagnostics Llc Biological specimen collection/transport compositions and methods
US8283423B2 (en) 2006-09-29 2012-10-09 Massachusetts Institute Of Technology Polymer synthetic technique
US8802447B2 (en) 2006-10-05 2014-08-12 Massachusetts Institute Of Technology Emissive compositions with internal standard and related techniques
US20090215189A1 (en) * 2006-10-27 2009-08-27 Massachusetts Institute Of Technology Sensor of species including toxins and chemical warfare agents
WO2008061165A2 (en) 2006-11-14 2008-05-22 Handylab, Inc. Microfluidic cartridge and method of making same
EP2099930B1 (de) * 2006-12-13 2015-02-18 Luminex Corporation Systeme und verfahren für pcr-multiplexanalyse in echtzeit
WO2008079972A2 (en) 2006-12-20 2008-07-03 Bayer Healthcare Llc 4-{4- [ ({3-tert-butyl-1- [3- (hydroxymethyl) phenyl] - 1h- pyrazol- 5 -yl } carbamoyl) -amin o] -3-chlorophenoxy} -n-methylpyridine-2-carboxamide as an inhibitor of the vegfr kinase for the treatment of cancer
US8535888B2 (en) * 2006-12-29 2013-09-17 Mayo Foundation For Medical Education And Research Compositions and methods for detecting methicillin-resistant S. aureus
US20120135873A1 (en) * 2007-01-29 2012-05-31 Noga Porat Genome determination assay
US7794939B2 (en) * 2007-02-26 2010-09-14 University Of Idaho Methods of DNA methylation detection
FI20070163A0 (fi) 2007-02-27 2007-02-27 Hidex Oy Parannettu homogeeninen luminesenssibiotesti
US8906354B2 (en) 2007-02-28 2014-12-09 Bruker Biospin Corporation Loaded latex optical molecular imaging probes containing lipophilic large stokes shift dyes
US8017104B2 (en) * 2007-02-28 2011-09-13 Carestream Health, Inc. Large stoke shift dye used for optical imaging
US20110020239A1 (en) * 2007-05-14 2011-01-27 The Johns Hopkins University Methods for in vivo imaging of cells
US20090136385A1 (en) 2007-07-13 2009-05-28 Handylab, Inc. Reagent Tube
US9186677B2 (en) 2007-07-13 2015-11-17 Handylab, Inc. Integrated apparatus for performing nucleic acid extraction and diagnostic testing on multiple biological samples
US8133671B2 (en) 2007-07-13 2012-03-13 Handylab, Inc. Integrated apparatus for performing nucleic acid extraction and diagnostic testing on multiple biological samples
US8287820B2 (en) 2007-07-13 2012-10-16 Handylab, Inc. Automated pipetting apparatus having a combined liquid pump and pipette head system
US8105783B2 (en) 2007-07-13 2012-01-31 Handylab, Inc. Microfluidic cartridge
WO2009012185A1 (en) 2007-07-13 2009-01-22 Handylab, Inc. Polynucleotide capture materials, and methods of using same
US9618139B2 (en) 2007-07-13 2017-04-11 Handylab, Inc. Integrated heater and magnetic separator
US8182763B2 (en) 2007-07-13 2012-05-22 Handylab, Inc. Rack for sample tubes and reagent holders
USD621060S1 (en) 2008-07-14 2010-08-03 Handylab, Inc. Microfluidic cartridge
US11041215B2 (en) 2007-08-24 2021-06-22 Longhorn Vaccines And Diagnostics, Llc PCR ready compositions and methods for detecting and identifying nucleic acid sequences
US9683256B2 (en) 2007-10-01 2017-06-20 Longhorn Vaccines And Diagnostics, Llc Biological specimen collection and transport system
US8821885B2 (en) 2007-08-27 2014-09-02 Longhorn Vaccines & Diagnostics, Llc Immunogenic compositions and methods
US10004799B2 (en) 2007-08-27 2018-06-26 Longhorn Vaccines And Diagnostics, Llc Composite antigenic sequences and vaccines
US8357656B2 (en) * 2007-09-15 2013-01-22 Mayo Foundation For Medical Education And Research Natriuretic peptide receptor-C agonists
ATE505562T1 (de) * 2007-09-28 2011-04-15 3M Innovative Properties Co Doppel-oligonukleotid- nukleinsäurenachweisverfahren
AU2008343745B2 (en) 2007-10-01 2012-05-10 Longhorn Vaccines & Diagnostics Llc Biological specimen collection and transport system and methods of use
US11041216B2 (en) 2007-10-01 2021-06-22 Longhorn Vaccines And Diagnostics, Llc Compositions and methods for detecting and quantifying nucleic acid sequences in blood samples
US20090111100A1 (en) * 2007-10-30 2009-04-30 Eugene Lukhtanov Minor groove binder - energy transfer oligonucleotides and methods for their use
US8123841B2 (en) 2008-01-16 2012-02-28 The Board Of Trustees Of The University Of Illinois Column design for micro gas chromatograph
EP2252702B1 (de) * 2008-02-08 2014-01-29 Mayo Foundation for Medical Education and Research Nachweis von clostridium difficile
US8034568B2 (en) 2008-02-12 2011-10-11 Nugen Technologies, Inc. Isothermal nucleic acid amplification methods and compositions
GB2470672B (en) 2008-03-21 2012-09-12 Nugen Technologies Inc Methods of RNA amplification in the presence of DNA
US8269029B2 (en) 2008-04-08 2012-09-18 The Board Of Trustees Of The University Of Illinois Water repellent metal-organic frameworks, process for making and uses regarding same
US20090270269A1 (en) * 2008-04-28 2009-10-29 Ashok Kumar Nano-scale fluoro-biosensors exhibiting a low false alarm rate for rapid detection of biological contaminants
WO2009152492A1 (en) * 2008-06-13 2009-12-17 University Of Connecticut Nucleic acid materials for nonradiative energy transfer and methods of production and use
USD618820S1 (en) 2008-07-11 2010-06-29 Handylab, Inc. Reagent holder
US8097412B2 (en) * 2008-07-12 2012-01-17 Biodiagnostics, Inc. DNA-based test for detection of annual and intermediate ryegrass
USD787087S1 (en) 2008-07-14 2017-05-16 Handylab, Inc. Housing
US20110218158A1 (en) * 2008-09-22 2011-09-08 Harris Reuben S Dna cytosine deaminase inhibitors
SG173081A1 (en) 2009-01-30 2011-08-29 Kantonsspital Aarau Ag Gene dosage analysis
WO2010135319A1 (en) * 2009-05-18 2010-11-25 University Of Connecticut Nucleic acid-based photovoltaic cell
WO2011012280A1 (en) 2009-07-30 2011-02-03 Roche Diagnostics Gmbh A set of oligonucleotide probes as well as methods and uses related thereto
WO2011022589A2 (en) * 2009-08-20 2011-02-24 Mayo Foundation For Medical Education And Research Detection of enterovirus
US9506057B2 (en) 2010-03-26 2016-11-29 Integrated Dna Technologies, Inc. Modifications for antisense compounds
US20120108799A1 (en) 2010-09-07 2012-05-03 Integrated Dna Technologies, Inc. Modifications for Antisense Compounds
EP2553123B1 (de) 2010-03-26 2016-08-24 Integrated DNA Technologies, Inc. Verfahren zur verstärkung einer nukleinsäurehybridisierung
CN103079567A (zh) 2010-04-17 2013-05-01 拜尔健康护理有限责任公司 用于疾病和病症的治疗和预防的氟取代的ω-羧基芳基二苯脲的合成代谢产物
EP2495336B8 (de) 2011-03-04 2014-07-23 Roche Diagnostics GmbH Neuer Typ von universellen Sonden zur Detektion von Genomvarianten
CN106190806B (zh) 2011-04-15 2018-11-06 贝克顿·迪金森公司 扫描实时微流体热循环仪和用于同步的热循环和扫描光学检测的方法
US9034581B2 (en) 2011-05-26 2015-05-19 Roche Molecular Systems, Inc. Compositions and methods for detection of Staphylococcus aureus
CN103906761B (zh) 2011-08-30 2016-12-21 梅约医学教育与研究基金会 利钠多肽
US8756890B2 (en) * 2011-09-28 2014-06-24 Romeo Ilarian Ciuperca Insulated concrete form and method of using same
USD692162S1 (en) 2011-09-30 2013-10-22 Becton, Dickinson And Company Single piece reagent holder
KR102121853B1 (ko) 2011-09-30 2020-06-12 벡톤 디킨슨 앤드 컴퍼니 일체화된 시약 스트립
CN104040238B (zh) 2011-11-04 2017-06-27 汉迪拉布公司 多核苷酸样品制备装置
US9611305B2 (en) 2012-01-06 2017-04-04 Mayo Foundation For Medical Education And Research Treating cardiovascular or renal diseases
CA3207612A1 (en) 2012-01-26 2013-08-01 Longhorn Vaccines And Diagnostics, Llc Composite antigenic sequences and vaccines
CN107881219B (zh) 2012-02-03 2021-09-10 贝克顿·迪金森公司 用于分子诊断测试分配和测试之间兼容性确定的外部文件
US9982313B2 (en) 2012-08-17 2018-05-29 Roche Molecular Systems, Inc. Compositions and methods for detection of herpes simplex virus 1 and 2
US8636941B1 (en) 2012-09-25 2014-01-28 Romeo Ilarian Ciuperca Methods of making concrete runways, roads, highways and slabs on grade
US9458637B2 (en) 2012-09-25 2016-10-04 Romeo Ilarian Ciuperca Composite insulated plywood, insulated plywood concrete form and method of curing concrete using same
US9593371B2 (en) * 2013-12-27 2017-03-14 Intel Corporation Integrated photonic electronic sensor arrays for nucleic acid sequencing
EP2948566A4 (de) 2013-01-24 2016-10-05 California Inst Of Techn Chromophorenbasierte charakterisierungs- und erkennungsverfahren
US20140249037A1 (en) 2013-03-04 2014-09-04 Fry Laboratories, LLC Method and kit for characterizing microorganisms
US8844227B1 (en) 2013-03-15 2014-09-30 Romeo Ilarian Ciuperca High performance, reinforced insulated precast concrete and tilt-up concrete structures and methods of making same
CA2911409C (en) 2013-05-13 2021-03-02 Romeo Ilarian Ciuperca Insulated concrete battery mold, insulated passive concrete curing system, accelerated concrete curing apparatus and method of using same
US10065339B2 (en) 2013-05-13 2018-09-04 Romeo Ilarian Ciuperca Removable composite insulated concrete form, insulated precast concrete table and method of accelerating concrete curing using same
KR101847748B1 (ko) 2013-08-22 2018-04-10 소니 주식회사 수용성 형광 또는 유색 염료 및 그의 사용 방법
US9862118B2 (en) 2013-09-09 2018-01-09 Romeo Ilarian Ciuperca Insulated flying table concrete form, electrically heated flying table concrete form and method of accelerating concrete curing using same
US9776920B2 (en) * 2013-09-09 2017-10-03 Romeo Ilarian Ciuperca Insulated concrete slip form and method of accelerating concrete curing using same
US10072288B2 (en) 2013-11-11 2018-09-11 Roche Molecular Systems, Inc. Detecting single nucleotide polymorphism using overlapped primer and melting probe
US9745618B2 (en) 2014-11-19 2017-08-29 Roche Molecular Systems, Inc. Photoblocked probes and methods for sequential detection of nucleic acids
US9920381B2 (en) 2014-12-02 2018-03-20 Roche Molecular Systems, Inc. Compositions and methods for detecting MECC-containing methicillin-resistant Staphylococcus aureus
WO2016138457A1 (en) 2015-02-26 2016-09-01 Sony Corporation Phenylethynylnaphthalene dyes and methods for their use
KR20170120677A (ko) 2015-02-26 2017-10-31 소니 주식회사 접합 그룹을 포함하는 수용성 형광 또는 착색 염료
US10968475B2 (en) 2015-05-01 2021-04-06 Vanderbilt University Monitoring and analysis of nucleic acid hybridization state and amplification using L-DNA
KR20180005650A (ko) 2015-05-11 2018-01-16 소니 주식회사 초휘도 이량체성 또는 중합체성 염료
US9976136B2 (en) 2015-05-14 2018-05-22 Longhorn Vaccines And Diagnostics, Llc Rapid methods for the extraction of nucleic acids from biological samples
CA2956649A1 (en) 2016-01-31 2017-07-31 Romeo Ilarian Ciuperca Self-annealing concrete forms and method of making and using same
JP6962927B2 (ja) 2016-03-11 2021-11-05 エフ.ホフマン−ラ ロシュ アーゲーF. Hoffmann−La Roche Aktiengesellschaft ジカウイルス検出用組成物および方法
CA3018564A1 (en) 2016-04-01 2017-10-05 Sony Corporation Ultra bright dimeric or polymeric fluorescent and colored dyes
KR102525252B1 (ko) 2016-04-01 2023-04-26 소니그룹주식회사 강성 공간군을 갖는 매우 밝은 이량체성 또는 중합체성 염료
AU2017248165B2 (en) 2016-04-06 2021-08-26 Sony Group Corporation Ultra bright dimeric or polymeric dyes with spacing linker groups
WO2017197014A2 (en) 2016-05-10 2017-11-16 Sony Corporation Compositions comprising a polymeric dye and a cyclodextrin and uses thereof
WO2017196954A1 (en) 2016-05-10 2017-11-16 Sony Corporation Ultra bright polymeric dyes with peptide backbones
CN109071961B (zh) 2016-05-11 2021-04-27 索尼公司 超亮二聚或聚合染料
US10612101B2 (en) 2016-05-27 2020-04-07 Roche Molecular Systems, Inc. Compositions and methods for detection of Mycoplasma genitalium
EP3464617B1 (de) 2016-05-27 2021-04-07 Roche Diagnostics GmbH Zusammensetzungen und verfahren zur detektion von trichomonas vaginalis
JP7068191B2 (ja) 2016-06-06 2022-05-16 ソニーグループ株式会社 蛍光または有色レポーター基を含むイオン性ポリマー
CA3031994A1 (en) 2016-07-29 2018-02-01 Juno Therapeutics, Inc. Methods for assessing the presence or absence of replication competent virus
WO2018024562A1 (en) 2016-08-02 2018-02-08 Roche Diagnostics Gmbh Helper oligonucleotide for improving efficiency of amplification and detection/quantitation of nucleic acids
US10793923B2 (en) 2016-11-09 2020-10-06 Roche Molecular Systems, Inc. Compositions and methods for detection of BK virus
US20190211377A1 (en) 2016-12-22 2019-07-11 Roche Molecular Systems, Inc. Cobra probes to detect a marker for epidemic ribotypes of clostridium difficile
CN111148987B (zh) * 2017-06-16 2023-04-14 杜克大学 用于改善标记检测、计算、分析物感应和可调随机数生成的谐振器网络
US10760137B2 (en) 2017-07-18 2020-09-01 Roche Molecular Systems, Inc. Compositions and methods for detection of Babesia
JP7287942B2 (ja) * 2017-07-24 2023-06-06 クアンタム-エスアイ インコーポレイテッド 高強度標識反応物組成物および配列決定のための方法
WO2019063661A1 (en) 2017-09-29 2019-04-04 Roche Diagnostics Gmbh COMPOSITIONS AND METHODS FOR THE DETECTION OF TRICHOMONAS VAGINALIS
US20210032277A1 (en) 2017-10-05 2021-02-04 Sony Corporation Programmable polymeric drugs
WO2019099789A1 (en) 2017-11-16 2019-05-23 Sony Corporation Programmable polymeric drugs
WO2019152747A1 (en) 2018-01-31 2019-08-08 Juno Therapeutics, Inc. Methods and reagents for assessing the presence or absence of replication competent virus
JP2021520423A (ja) 2018-03-19 2021-08-19 ソニーグループ株式会社 蛍光シグナルを増強するための二価金属の使用
WO2019182766A1 (en) * 2018-03-21 2019-09-26 Sony Corporation Polymeric tandem dyes with linker groups
EP3891302A1 (de) 2018-12-03 2021-10-13 F. Hoffmann-La Roche AG Zusammensetzungen und verfahren zum nachweis von candida auris
WO2020154546A1 (en) 2019-01-23 2020-07-30 Quantum-Si Incorporated High intensity labeled reactant compositions and methods for sequencing
CN113785073A (zh) 2019-05-02 2021-12-10 豪夫迈·罗氏有限公司 基于链分离温度利用dITP进行RNA靶标相比于DNA靶标的优先性/选择性扩增
US20220220539A1 (en) 2019-05-07 2022-07-14 Roche Molecular Systems, Inc. Compositions and methods for detection of neisseria gonorroheae
EP4004240B1 (de) 2019-07-25 2024-03-13 F. Hoffmann-La Roche AG Zusammensetzungen und verfahren zur detektion von epstein-barr-virus (ebv)
US11739382B2 (en) 2019-08-27 2023-08-29 Roche Molecular Systems, Inc. Compositions and methods for amplification and detection of hepatitis B virus RNA, including HBV RNA transcribed from cccDNA
WO2021062176A2 (en) 2019-09-26 2021-04-01 Sony Corporation Polymeric tandem dyes with linker groups
US11441167B2 (en) 2019-11-20 2022-09-13 Roche Molecular Systems, Inc. Compositions and methods for rapid identification and phenotypic antimicrobial susceptibility testing of bacteria and fungi
EP4081666A2 (de) 2019-12-27 2022-11-02 F. Hoffmann-La Roche AG Zusammensetzungen und verfahren zum nachweis von methicillin-resistentem staphylococcus aureus
EP4085156B1 (de) 2019-12-31 2023-10-25 F. Hoffmann-La Roche AG Quantitatives pcr-screening von induzierbaren prophagen aus bakterienisolaten
CA3166337A1 (en) 2020-03-09 2021-09-16 F. Hoffmann-La Roche Ag Compositions and methods for detecting severe acute respiratory syndrome coronavirus 2 (sars-cov-2), influenza a and influenza b
AU2021322710A1 (en) 2020-08-06 2023-02-02 F. Hoffmann-La Roche Ag Compositions and methods for the detection of severe acute respiratory syndrome coronavirus 2 (SARS-2), influenza A, and influenza B
JP2023552546A (ja) 2020-12-04 2023-12-18 エフ. ホフマン-ラ ロシュ アーゲー マラリアを検出するための組成物および方法
US20220205020A1 (en) 2020-12-30 2022-06-30 Roche Molecular Systems, Inc. Compositions and methods for detection of bacteria and fungi associated with bacterial and candida vaginosis
WO2022167570A1 (en) 2021-02-05 2022-08-11 F. Hoffmann-La Roche Ag Compositions and methods for detection of human parainfluenza viruses 1-4 (hpiv 1-4)
US20220290221A1 (en) 2021-03-15 2022-09-15 Roche Molecular Systems, Inc. Compositions and methods for detecting severe acute respiratory syndrome coronavirus 2 (sars-cov-2) variants having spike protein mutations
CN117858960A (zh) 2021-05-06 2024-04-09 豪夫迈·罗氏有限公司 用于通过双靶标测定来检测丁型肝炎病毒的组合物和方法
CA3230272A1 (en) * 2021-09-07 2023-03-16 Eric Kool Compositions, systems, and methods for nucleic acid data storage
WO2023079032A1 (en) 2021-11-05 2023-05-11 F. Hoffmann-La Roche Ag Compositions and methods for detection of malaria
WO2023089186A1 (en) 2021-11-22 2023-05-25 F. Hoffmann-La Roche Ag Compositions and methods for detecting vana and/or vanb genes associated with multidrug resistance
WO2023118399A1 (en) 2021-12-24 2023-06-29 F. Hoffmann-La Roche Ag Improved detection of lamp amplification products
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WO2024042042A1 (en) 2022-08-24 2024-02-29 F. Hoffmann-La Roche Ag Compositions and methods for detecting monkeypox virus

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1273552A (en) * 1985-12-23 1990-09-04 Michael J. Heller Fluorescent stokes shift probes for polynucleotide hybridization assays
US4996143A (en) * 1985-12-23 1991-02-26 Syngene, Inc. Fluorescent stokes shift probes for polynucleotide hybridization
ATE88761T1 (de) * 1986-01-10 1993-05-15 Amoco Corp Kompetitiver homogener test.
US4868103A (en) * 1986-02-19 1989-09-19 Enzo Biochem, Inc. Analyte detection by means of energy transfer
US4822746A (en) 1986-06-25 1989-04-18 Trustees Of Tufts College Radiative and non-radiative energy transfer and absorbance modulated fluorescence detection methods and sensors
US5322770A (en) * 1989-12-22 1994-06-21 Hoffman-Laroche Inc. Reverse transcription with thermostable DNA polymerases - high temperature reverse transcription
US5210015A (en) * 1990-08-06 1993-05-11 Hoffman-La Roche Inc. Homogeneous assay system using the nuclease activity of a nucleic acid polymerase
US5237515A (en) * 1991-04-10 1993-08-17 University Of Utah Research Foundation Method of determining energy transfer efficiency of a donor-acceptor pair of fluorescent dyes
US5405747A (en) * 1991-09-25 1995-04-11 The Regents Of The University Of California Office Of Technology Transfer Method for rapid base sequencing in DNA and RNA with two base labeling
JP3509859B2 (ja) * 1991-11-07 2004-03-22 ナノトロニクス,インコーポレイテッド 供与体−供与体エネルギー転移系を創製するための発色団および蛍光団でコンジュゲート化されたポリヌクレオチドのハイブリダイゼーション
US5332659A (en) * 1992-04-09 1994-07-26 The United States Of America As Represented By The Secretary Of The Navy Light emission-or absorbance-based binding assays for polynucleic acids

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EP1067134A2 (de) 2001-01-10
ATE201692T1 (de) 2001-06-15
JP3509859B2 (ja) 2004-03-22
JPH07502992A (ja) 1995-03-30
US6416953B1 (en) 2002-07-09
AU667497B2 (en) 1996-03-28
DE69231853D1 (de) 2001-07-05
WO1993009128A1 (en) 1993-05-13
CA2123133C (en) 2005-01-04
US6911310B2 (en) 2005-06-28
EP0620822A1 (de) 1994-10-26
EP1067134A3 (de) 2001-05-02
US6162603A (en) 2000-12-19
EP1067134B1 (de) 2004-07-28
US5565322A (en) 1996-10-15
CA2123133A1 (en) 1993-05-13
EP0620822B1 (de) 2001-05-30
DK0620822T3 (da) 2001-08-27
DE69233391D1 (de) 2004-09-02
GR3036456T3 (en) 2001-11-30
US5532129A (en) 1996-07-02
US5849489A (en) 1998-12-15
AU3136493A (en) 1993-06-07
US20030054361A1 (en) 2003-03-20
ATE272068T1 (de) 2004-08-15
US20070042386A1 (en) 2007-02-22
EP0620822A4 (en) 1996-01-10
ES2159282T3 (es) 2001-10-01

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